Patents and Patent Applications from Louisiana State University System


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US20190346422 UNIVERSAL MOLECULAR PROCESSOR FOR PRECISION MEDICINE  
The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid...
US20190345453 FUNCTIONAL FELINE PANCREATIC CELLS FROM ADIPOSE TISSUE  
Compositions and methods are described herein for transdifferentiation of multipotent stromal cells into cells that can express insulin.
US20190336581 IMMUNOSTIMULATORY COMPOSITIONS AND USES THEREFOR  
Disclosed are compositions and methods for stimulating immune responses. More particularly, these compositions and methods involve the use of an inhibitor of IL-25 function and an immune...
10465202 Abiotic stress resistance  
Transformed plants are disclosed with enhanced resistance to abiotic stresses, such as salt stress, water stress, or temperature stress. Also disclosed are vectors useful for making such...
10463689 Pharmaceutical formulations of nitrite and uses thereof  
The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of...
US20190328690 METHODS FOR TREATING C-MET-DEPENDENT CANCERS  
A method of treating cancer or a precancer condition in a mammal comprising administering a therapeutically effective amount of a homovanillyl sinapate analog or pharmacologically acceptable salt,...
US20190321450 Composition and Method for Improving Sleep Duration and Quality  
An intervention for sleep disorders comprises collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative; hyaluronic...
US20190320655 Method for Controlling Hematophagous or Sap-Feeding Arthropods  
Modulation of inward potassium ion conductance with structurally diverse small-molecules in the arthropod salivary gland induces arthropod salivary gland failure that results in a reduction or...
US20190314423 PLACENTAL MESENCHYMAL STEM CELLS, METHODS OF PRODUCTION, AND PLACENTAL MESENCHYMAL STEM CELL BASED THERAPEUTICS  
A replicating in vitro cell culture of human placental mesenchymal stem cells comprising; cells which maintain a potential to differentiate to derivatives of multiple progenitor cell types...
US20190313501 CARBON DOT LIGHT EMITTING DIODES  
An electroluminescent LED device comprising a hole transport layer, an electron transport layer, an active emissive layer between the hole transport layer and the electron transport layer, and...
10435344 Reaction sequence for the synthesis of nootkatone, dihydronootkatone, and tetrahydronootkatone  
An inexpensive, stereoselective synthesis for nootkatone, tetrahydronootkatone, and their derivatives is disclosed utilizing ozonolysis. The starting materials used in the synthesis are...
10429378 Methods of differentiating preadipocytes and uses thereof  
Described herein are methods of transdifferentiating preadipocytes, populations of transdifferentiated preadipocytes, and methods of using the transdifferentiated preadipocytes.
10429376 Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids  
Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple...
US20190292522 NOTCH ACTIVATION ENHANCES MESENCHYMAL STEM CELL SHEET OSTEOGENIC POTENTIAL BY INHIBITION OF CELLULAR SENESCENCE  
A method of retaining multi-potency in stem cells comprising one of reducing p16RNA expression and increasing Hes1 expression. A therapeutic comprising a high density sheet of stem cells wherein...
US20190291084 CATALYTIC REACTION  
Reaction methods are disclosed including induction catalysts. Such reactions may involve heating a catalyst by inductive heating; contacting the catalyst with a composition such that a reaction...
US20190284396 Smart Rutting and Cracking Resistant Asphalt Pavement Incorporating Shape Memory Polymers  
The low temperature cracking and high temperature rutting of polymer-modified asphalt concrete pavement can be reduced. The composite includes asphalt and at least one polymer that expands at low...
10416150 Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids  
Microdevices are disclosed to efficiently, accurately, and rapidly isolate and enumerate rare cells, such as circulating tumor cells, from liquids such as whole blood. The system employs multiple...
US20190274981 OLEANOLIC ACID ENHANCES MESENCHYMAL STROMAL CELL OSTEOGENIC POTENTIAL BY INHIBITION OF NOTCH SIGNALING  
A method of increasing mesenchymal stromal cell osteogenic potential in a patient comprising administering to the patient a therapeutic that inhibits Notch signaling. A method of stimulating one...
10393726 Universal molecular processor for precision medicine  
The present invention is directed to a device that comprises a biomolecular processor and one or more nanotubes. Each biomolecular processor comprises a bioreactor chamber defined by a solid...
10392394 Antimicrobial compounds and methods  
Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties. The compounds may be...
US20190257833 COMPOSITIONS AND METHODS TO DETECT GASTROINTESTINAL DISEASE  
This invention is directed to compositions and methods to detect and treat gastrointestinal diseases.
US20190256634 Composition and Method of Making Two-Way Shape Memory Polymer Based Sealant  
A sealant composition and method for its manufacture are disclosed. A two-way shape memory polymer (2W-SMP) sealant expands upon cooling and contracts upon heating, and thus provides improved...
US20190254987 Delivery of Bioactive, Nanoencapsulated Antioxidants  
Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The...
US20190247452 TUMOR-SPECIFIC ADENOVIRUS VECTORS AND THERAPEUTIC USES  
A conditionally replicating adenovirus were generated that can specifically replicate and express therapeutic genes in neuroendocrine tumors. The promoter-specific expression of the adenoviruses...
10376618 Thoracic catheter device  
A thoracic catheter system comprises a flexible thoracic catheter for inserting into a thoracic cavity of a human. A distal end of the thoracic catheter has a plurality of apertures. A proximate...
10376566 Composition and method for improving sleep duration and quality  
An intervention for sleep disorders comprises: collagen, a gelatin peptide, or the amino acid glycine; L-theanine; lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative;...
US20190242208 MAGNETORHEOLOGICAL DOWN-HOLE PACKING ELEMENTS  
Aspects of drilling, production, hydraulic fracturing, and well work-over operations operations that create full seal magnetorheological down-hole packing elements are described. Some examples...
US20190234922 HYDROGEN SULFIDE DETECTING APPARATUS  
Methods and hydrogen sulfide (H2S) detecting apparatuses comprising a single reaction chamber defining a first volume, a single trapping chamber positioned adjacent to the reaction chamber...
US20190233429 CONFORMATIONALLY-CONSTRAINED BIOISOSTERES OF CAFFEIC ACID, AND SYNTHESIS AND THERAPEUTIC USES  
A method of treating a disease condition in a mammal comprising administering a pharmacologically effective amount of a therapeutic, wherein the therapeutic includes a bioisosteres of caffeic...
US20190231933 HUMAN MESENCHYMAL STROMAL CELL SHEET ENHANCES ALLOGRAFT REPAIR IN A MOUSE MODEL  
A tissue engineered periosteum for a patient comprising a sheet of stem cells. A method of repairing bone injury on a patient comprising implanting into the patient an engineered bone graph...
US20190231902 METHOD FOR DELIVERING RNA TO NEURONS TO TREAT HERPES INFECTIONS  
Aspects of the application relate to methods and compositions for delivering therapeutic nucleic acids to neural cells or tissue in a subject. Additional aspects of the application relate to...
10363292 Vaccination with anti-tick antigens to control multiple tick species and disease transmission in white-tailed deer and other host animals  
Compositions of either the Rm86Texas protein from a Texas outbreak strain of the southern cattle fever tick, Rhipicephalus microplus, or a nucleic acid construct incorporating a nucleic acid...
10363117 Overload failure reducing dental implants  
A dental implant including a base, a central shaft and a shock absorber spacing and allowing limited movement between the base and the central shaft. The shock absorber may also contain a...
US20190224211 DEVICES AND METHODS OF TREATING METHAMPHETAMINE ADDICTION AND MEDICAL AND BEHAVIORAL CONSEQUENCES OF METHAMPHETAMINE USE AND OF HIV INFECTION  
A method of treating a condition of in a human patient comprising pharmacologically activating a translocator protein of 18 kDa (TSPO), wherein the condition is one of a chronic methamphetamine...
US20190210922 Self-Healing Composite of Thermoset Polymer and Programmed Super Contraction Fibers  
A composition comprising thermoset polymer, shape memory polymer to facilitate macro scale damage closure, and a means for molecular scale healing is disclosed; the composition has the ability to...
10334685 Carbon dot light emitting diodes  
An electroluminescent LED device comprising a hole transport layer, an electron transport layer, an active emissive layer between the hole transport layer and the electron transport layer, and...
10328422 Acidic catalyst  
Catalysts are disclosed having metal oxide support structures and acidic reaction sites. The reaction sites may be according to the general formula MxOyAlBrzX]−H+ where x is one or two; y is one...
10328147 Herpes simplex virus type-1(HSV-1) vaccine strain VC2 generating an anti-EHV-1 immune response  
Embodiments of nucleic acids comprise a nucleotide sequence encoding a live-attenuated chimeric Herpes Simplex Virus Type-1 (HSV-1) VC2 virus and a nucleotide sequence encoding a heterologous...
10327661 Biomarkers for determining susceptibility to SUDEP  
A method for determining an increased risk of death of a patient includes receiving ECG data of the patient generated during a first time period; receiving EEG data of the patient generated during...
US20190185622 HYDROPHOBICALLY MODIFIED POLYPEPTOIDS AND USES THEREOF  
A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types...
US20190177741 A GREEN ALGA BICARBONATE TRANSPORTER AND USES THEREOF  
Provided herein are green alga Cia8 polypeptides and the polynucleotides that encode them. Also provided herein are transformed cells and transgenic plants that include one or more of the...
10308939 Use of an miRNA to reduce proliferation of a cancer cell  
A method is provided for decreasing at least one of the proliferation and the migration of a cancer cell comprising contacting a cancer cell with an effective amount of a pharmaceutically...
10307750 Production of oil by pyrolysis of coal  
Catalysts useful in transforming biomass to bio-oil are disclosed, as are methods for making such catalysts, and methods of transforming biomass to bio-oil. The catalysts are especially useful...
10307441 Pharmaceutical formulations of nitrite and uses thereof  
The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of...
US20190164736 DEVICES AND METHODS FOR MAI IONIZATION  
Mass spectrometry systems and methods including ionization devices are provided. The ionization device includes either a gas pulse valve or a piezoelectric striker. The ionization device is...
US20190160106 COMPOSITIONS AND METHODS FOR TREATING CARDIAC INJURY  
This invention is directed to compositions and methods for treating a condition of the heart. In an embodiment, the invention is directed to a method of treating a subject in need thereof, wherein...
US20190153130 CURE-ON-DEMAND AND TIME-LAPSE POLYMERIZATION  
The present invention provides compositions, methods and kits for the temporal control induction time for a polymerization reaction.
10292943 Delivery of bioactive, nanoencapsulated antioxidants  
Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The...
US20190133934 Ocular Drug Delivery Devices  
A method of forming an ocular delivery device includes exposing a solid, shaped cellulose polymer to a solution including an active pharmaceutical ingredient (API) and a solvent capable of...
10282347 Architecture for configuration of a reconfigurable integrated circuit  
A system and method includes generating, with a configuration controller, a configuration bitstream including configuration bits to dynamically define the configuration of a reconfigurable...