Patents and Patent Applications from Kansas State University


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US20180187236 HIGH-THROUGHPUT FLUORESCENT SCREENING ASSAY FOR INHIBITORS OF GRAM-NEGATIVE BACTERIAL IRON UPTAKE  
A cell-based assay for identifying a compound that inhibits iron transport in Gram-negative bacteria, engineered bacterial cells, and kits for conducting the same. The assay involves contacting a...
10010598 Compositions and methods for detecting, treating, and protecting against Fusobacterium infection  
The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin...
US20180148736 PLANT GERMPLASM RESISTANT TO RNA VIRUSES  
Disclosed is a dsRNA construct used to silencing specific eukaryotic translation initiation factor in plants to produce a plant resistant to viruses such as Potyviruses, Luteoviruses, and...
9977016 Two-dimensional fluorescence difference spectroscopy characterization of nanoparticles and their interactions  
Methods of characterizing nanoparticles, nanoparticle complexes, and their biomolecular interactions are provided. Concurrent excitation and emission wavelength scans are performed and the optimal...
9958561 Apparatus and method for the determination of one or more neutron source characteristics  
A neutron detection apparatus includes a neutron detector and an analyzer. The neutron detector includes a plurality of neutron detector assemblies, where each of the neutron detector assemblies...
9943592 Vaccine adjuvants from self-assembling peptides  
Pharmaceutical or veterinary compositions, vaccine systems, methods, and kits for treating or protecting a subject from a condition using peptide-based adjuvants are provided. The peptide...
US20180100853 GRAPHENE OXIDE-BASED NANOLAB AND METHODS OF DETECTING OF EXOSOMES  
A capture device for capturing a biological substance can include: a substrate; a graphene-oxide layer on the substrate; at least one polydopamine polymer coupled with the graphene-oxide; and at...
US20180099057 NANOPLATFORMS FOR ARGINASE, INDOLEAMINE 2,3-DIOXYGENASE AND TRYPTOPHAN 2,3-DIOXYGENASE DETECTION BY POSTTRANSLATIONAL MODIFICATION  
A nanoplatform assembly for detection of arginase, indoleamine 2,3-dioxygenase 1, and/or tryptophan 2,3-dioxygenase. The nanoplatform comprises an oligopeptide, which is used as a linker between...
US20180071382 COMPOSITIONS AND METHODS FOR DETECTING, TREATING, AND PROTECTING AGAINST FUSOBACTERIUM INFECTION  
The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin...
9909139 Plant germplasm resistant to RNA viruses  
Disclosed is a dsRNA construct used to silencing specific eukaryotic translation initiation factor in plants to produce a plant resistant to viruses such as Potyviruses, Luteoviruses, and...
9908905 Aluminum-modified polysilazanes for polymer-derived ceramic nanocomposites  
Methods for synthesizing aluminum-modified silazanes, their use as polymer-derived ceramic precursors, and polymer-derived ceramics and carbon nanotube core/shell nanocomposites formed therefrom...
US20180052767 STORAGE CLASS MEMORY (SCM) MEMORY MODE CACHE SYSTEM  
An SCM memory mode NVDIMM-N cache system includes an SCM subsystem, and an NVDIMM-N subsystem having at volatile memory device(s) and non-volatile memory device(s). A memory controller writes data...
9884102 Compositions and methods for detecting, treating, and protecting against Fusobacterium infection  
The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin...
US20180021421 ATTENUATED VACCINES TO PROTECT AGAINST TICK-BORNE EHRLICHIA SPECIES INFECTIONS  
Attenuated vaccines to protect vertebrate animals and people against tick-born rickettsial, Ehrlichia and Anaplasma species infections is disclosed. Also disclosed are methods to modify the...
US20180010170 CO-DETECTION AND ASSOCIATION OF MULTIPLE GENES FROM THE SAME GENOME IN A SAMPLE  
The present invention is concerned with PCR-based detection methods and kits for the identification, differentiation, and quantification of different bacterial strains (e.g., Gram-negative...
US20180008699 VACCINES FOR PORCINE EPIDEMIC DIARRHEA VIRUS INFECTIONS  
Isolated porcine epidemic diarrhea virus (PEDV) deposited under ATCC Accession No. PTA-121847, and attenuated strains generated by serial passage in culture of the deposited strain. Immunogenic...
9850520 Electrochemical detection of proteases using AC voltammetry on nanoelectrode arrays  
An electrochemical method for measuring the activity of enzymes using nanoelectrode arrays fabricated with vertically aligned carbon nanofibers. Short peptide substrates specific to...
US20170354167 CHEMICAL MITIGANTS IN ANIMAL FEED AND FEED INGREDIENTS  
Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as...
9802962 Tricyclic pyrone compounds reduce amyloid beta aggregates  
Tricyclic pyrone compounds having high oral bioavailability, excellent blood-brain barrier permeability, and low toxicity are presented. Administration of the compounds to Alzheimer's Disease...
9791445 Rift Valley Fever Virus glycoproteins, Gn and Gc, and their use  
The present invention describes subunit vaccines containing Gn and Gc glycoproteins of the Rift Valley Fever Virus, including nucleic acids encoding such glycoproteins, host cells, vectors, and...
US20170275644 PLANTS WITH ENHANCED TOLERANCE TO MULTIPLE ABIOTIC STRESSES  
The present disclosure describes genetically-modified plants having enhanced tolerance to multiple abiotic stressors, such as extreme temperatures (heat or cold) and/or drought. Abiotic stress...
US20170274064 MODIFIED BAT INFLUENZA VIRUSES AND THEIR USES  
Vaccine compositions useful for vaccination against a target influenza strain, and method and kits for using the same. The vaccines comprise a live attenuated influenza virus that is synthetically...
US20170265940 HIGH-EFFICIENCY, DIRECTIONAL MICROWAVE ABLATION ANTENNA  
An electrosurgical device (10) operable to deliver microwave energy to cause targeted tissue ablation is provided. The electrosurgical device (10) comprises an antenna (26), a reflector (30), and...
US20170234876 RAPID TEST TO DETERMINE THE NECESSITY OF REVACCINATION  
Rapid, point of care semi-quantitative tests for viral or bacterial antibody titer, and methods and kits for carrying out the same. The test article comprises a first elongated solid support with...
US20170232116 MULTIFUNCTIONAL METALLIC NANOPARTICLE-PEPTIDE BILAYER COMPLEXES  
Described are nanoparticulates comprising a metallic nanoparticle core and a peptide coating or shell encapsulating the nanoparticle core and being covalently bonded thereto. The coating is formed...
9731034 Protease assay  
The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell....
US20170219548 NANOSENSORS FOR DETECTING ENZYMATIC ACTIVITY IN DAIRY PRODUCTION  
Methods for detecting biomarkers of inflammation, infection, and/or bacterial activity in dairy production, which indicate issues with the milk itself or issues related to the health of the cow....
US20170204429 ACETYL-CoA CARBOXYLASE HERBICIDE RESISTANT SORGHUM  
The present invention provides for compositions and methods for producing crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants, plant...
US20170189334 PEPTIDE HYDROGEL PROPERTIES AND ITS APPLICATIONS  
Peptide hydrogels having a self-assembling, 3-dimensional nanofiber matrix are described. The nanofiber matrix comprises an amphiphilic peptide and optionally albumin. The peptide comprises...
US20170188602 GUMMY ANIMAL TREAT AND METHOD OF PREPARATION  
A process of forming a gelatin-based animal treat is provided. The process comprises forming a composition comprising a gelatin component, a carbohydrate material, and an aqueous liquid. The...
9682155 Protease assay  
The present invention provides a diagnostic reagent or assay for assessing the activity of a protease in vivo or in vitro and methods of detecting the presence of a cancerous or precancerous cell....
US20170145436 ACETOLACTATE SYNTHASE HERBICIDE RESISTANT SORGHUM  
The present invention provides for compositions and methods for producing sorghum crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants,...
US20170144935 SILICON-BASED POLYMER-DERIVED CERAMIC COMPOSITES COMPRISING H-BN NANOSHEETS  
Polymer-derived ceramic composites are described herein. The composites are formed using hexagonal boron nitride nanosheet-functionalized silicon-based ceramic precursor polymers. The composites a...
US20170137839 ACETOLACTATE SYNTHASE HERBICIDE RESISTANT SORGHUM  
The present invention provides for compositions and methods for producing sorghum crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants,...
US20170131272 TWO-DIMENSIONAL FLUORESCENCE DIFFERENCE SPECTROSCOPY CHARACTERIZATION OF NANOPARTICLES AND THEIR INTERACTIONS  
Methods of characterizing nanoparticles, nanoparticle complexes, and their biomolecular interactions are provided. Concurrent excitation and emission wavelength scans are performed and the optimal...
US20170107532 GENE ENCODING FHB1 RESISTANCE TO FUSARIUM HEAD BLIGHT DISEASE AND USES THEREOF  
A protein conferring resistance to Fusarium Head Blight disease (FHB) is described, along with the DNA sequence of the corresponding gene and mRNA copy (cDNA). The cDNA of Fhb1 gene can be used to...
9617530 Acetyl-CoA carboxylase herbicide resistant sorghum  
The present invention provides for compositions and methods for producing crop plants that are resistant to herbicides. In particular, the present invention provides for sorghum plants, plant...
US20170065978 NON-INVASIVE MONITORING CANCER USING INTEGRATED MICROFLUIDIC PROFILING OF CIRCULATING MICROVESICLES  
A microfluidic exosome profiling platform integrating exosome isolation and targeted proteomic analysis is disclosed. This platform is capable of quantitative exosomal biomarker profiling directly...
9587248 Mayetiola destructor susceptibility gene one (Mds-1) and its application in pest management  
Plants having increased resistance to a pest relative to corresponding control plants are provided. The resistant plants have inhibited expression, activity, or function of a susceptibility gene,...
9555405 Nanoparticle catalyst capable of forming aromatic hydrocarbons from CO2 and H2  
Nanocatalysts and methods of using the same to obtain aromatic hydrocarbon compounds from a source of carbon atoms and a source of hydrogen atoms in a single reaction step is provided. The...
9506081 Transgene construct to improve Fusarium head blight resistance in wheat and barley  
Resistance of plants, particularly wheat and barley, to Fusarium head blight (FHB) and other Fusarium-related diseases may be induced or enhanced by transformation with a nucleic acid (DNA)...
9474759 Broad-spectrum antivirals against 3C or 3C-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses  
Antiviral protease inhibitors, including peptidyl aldehydes, peptidyl α-ketoamides, peptidyl bisulfate salts, and peptidyl heterocycles, are disclosed, along with related antiviral compounds, and...
9465120 Apparatus and method for the determination of one or more neutron source characteristics  
A neutron detection system includes a plurality of neutron detector assemblies, the neutron detector assemblies including a plurality of neutron detection devices, wherein the neutron detection...
9458252 Starch esters and method of preparation  
A lipophilic starch is provided along with methods of making the same. The starch is prepared by modifying the starch with an organic acid anhydride reagent, such as octenyl succinic anhydride,...
9453111 Boron-modified silazanes for synthesis of SiBNC ceramics  
New methods for synthesizing boron-modified silazanes, their use as polymer-derived ceramic precursors, and polymer-derived ceramics and composites formed therefrom are disclosed. The polymeric...
9441112 Pressure sensitive adhesives, coatings, and films from plant oils  
Compositions useful for preparing pressure sensitive adhesives, coatings, and/or films are provided, along with methods of making and using the same. The compositions are made from renewable,...
9440857 Process for high-yield production of graphene via detonation of carbon-containing material  
A method of producing pristine graphene particles through a one-step, gas-phase, catalyst-free detonation of a mixture of one or more carbon-containing compounds hydrocarbon compounds and one or...
US20160250314 COMPOSITIONS AND METHODS FOR DETECTING, TREATING, AND PROTECTING AGAINST FUSOBACTERIUM INFECTION  
The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin...
US20160235044 IMMUNE COMPETENT MODELS OF HUMAN DISEASE  
Immunocompetent animal models having immunological tolerance to a xenograft and methods of producing the same. The animal models are tolerized to the xenograft in the pre-immune, fetal or...
US20160233305 DIRECT FORMATION OF GRAPHENE ON SEMICONDUCTOR SUBSTRATES AND STRUCTURES PREPARED THEREBY  
The invention generally related to a method for preparing a layer of graphene directly on the surface of a semiconductor substrate. The method includes forming a carbon-containing layer on a front...