Patents and Patent Applications from Johns Hopkins University


Match Document Document Title
10484628 Flexible pixel-wise exposure control and readout  
A pixel having a variable exposure for a scene capture device, the pixel comprising a photodiode, a buffer and a memory element and a switching mechanism. The memory element is configured to store...
10481165 Elevated CCL19 after completion of therapy for acute lyme disease identifies patients at risk for development of post-treatment lyme disease syndrome who will benefit from further antibiotic therapy  
The present invention relates to the field of Lyme disease. More specifically, the present invention provides methods and composition useful for the treatment of Lyme disease. In one aspect, the...
10478593 Catheter hub with removable extensions  
In one aspect, the present invention is directed to a multi-lumen catheter with self-sealing hub and an attachable extension assembly. In a preferred aspect, the present invention can allows...
10478458 In vitro pre-conditioned bone marrow-derived mesenchymal stem cells and uses thereof  
Disclosed is a composition including: an isolated in vitro pre-conditioned population of adult bone marrow derived mesenchymal stem cells (BMSCs), wherein the BMSCs express neuronal markers, and...
10478148 Self-calibrating projection geometry for volumetric image reconstruction  
The present invention is directed to a method for enabling volumetric image reconstruction from unknown projection geometry of tomographic imaging systems, including CT, cone-beam CT (CBCT), and...
10478120 MRI-guided intraarterial catheter-based method for predicting territory of local blood brain barrier opening  
The present invention provides a method of administering a therapeutic agent directly to the brain parenchym through a compromised region of the blood-brain barrier in a subject having a brain...
US20190344438 GENERATION OF ROBOTIC USER INTERFACE RESPONSIVE TO CONNECTION OF PERIPHERALS TO ROBOT  
Methods and systems for connection-driven generation of robotic user interfaces and modification of robotic properties include detecting a connection of a robotic peripheral to a robot; obtaining...
US20190343832 THERAPY FOR REMOVING SENESCENT CELLS AND TREATING SENESCENCE-ASSOCIATED DISEASE USING AN MDM2 INHIBITOR  
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases...
US20190343579 APPARATUS TO TREAT CARDIOPULMONARY DISEASE  
A treatment apparatus including: a bronchoscope including a flexible shaft having working channel; a transbronchial ablation probe configured to extend from a distal end of the working channel and...
10472315 Inhibitors of methionine aminopeptidases and methods of treating disorders  
The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using...
10471181 Fiber-hydrogel composite surgical meshes for tissue repair  
The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of...
10471172 Methods of making drug loaded microfiber sutures for ophthalmic application  
Ophthalmic suture materials made from biocompatible and biodegradable polymers with high tensile strength for use in drug delivery, methods of making them, and method of using them for ocular...
10470924 Reservoir device for intraocular drug delivery  
A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber...
US20190338294 ORTHOGONAL TRANSCRIPTIONAL SWITCHES DERIVED FROM TET REPRESSOR HOMOLOGS FOR SACCHAROMYCES CEREVISIAE  
The invention features compositions and methods for identifying orthogonal transcriptional switches derived from Tet repressor homologs for Saccharomyces cerevishiae regulated by...
US20190336466 METHODS OF TREATING RETINAL DISEASES  
A method of treating or inhibiting degeneration of a retina of a subject in need thereof comprising administering an effective amount of a compound of metipranolol, or a metabolite thereof, to an...
10463768 Composite material for tissue restoration  
A composite material can include a gel and at least one nanostructure disposed within the gel. A method for healing a soft tissue defect can include applying a composite material to a soft tissue...
10463750 Antigen-Specific T cell redirectors  
This disclosure describes compositions and methods for selectively recruiting antigen-specific T cells and re-direct them to kill targeted cells, particularly tumor cells. This approach permits...
US20190330367 DEVELOPMENT OF NEW MONOCLONAL ANTIBODIES RECOGNIZING HUMAN PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)  
The presently disclosed subject matter provides compositions and methods comprising isolated antibodies that can recognize human prostate-specific membrane antigen (PSMA). The presently disclosed...
US20190329364 Object Recognition and Presentation for the Visually Impaired  
An apparatus configured to perform object recognition is provided that includes a camera, an assistance feedback device, and processing circuitry. The processing circuitry may be configured to...
US20190328666 CYCLODEXTRIN COMPOSITIONS ENCAPSULATING A SELECTIVE ATP INHIBITOR AND USES THEREOF  
The invention provides compositions comprising cyclodextrins encapsulating a selective ATP inhibitor, as well as uses thereof.
US20190328665 LIPOSOME COMPOSITIONS ENCAPSULATING MODIFIED CYCLODEXTRIN COMPLEXES AND USES THEREOF  
The invention provides liposome compositions comprising liposomes encapsulating cyclodextrins that both bear ionizable functional groups, such as on their solvent-exposed surfaces, and encompass...
10461374 Battery internal temperature sensing battery management system  
A method is provided. The method is executable by a processor of a battery management system. The method includes sending a first command signal to a multiplexer to cause the multiplexer to select...
10459045 Sterile RF coils for MR imaging systems  
Sterile RF coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an RF coil housing and...
10457992 Hypermethylation biomarkers associated with poor survival outcomes for head and neck squamous cell cancer  
In accordance with one or more embodiments, the inventors have conducted the first comprehensive integrated genomic and epigenomic analysis in HNSCC, focusing on identifying genes that have...
US20190321488 HIGHLY STABLE BIODEGRADABLE GENE VECTOR PLATFORMS FOR OVERCOMING BIOLOGICAL BARRIERS  
A major challenge in non-viral gene delivery remains finding a safe and effective delivery system. Colloidally stable non-viral gene vector delivery systems capable of overcoming various...
US20190321310 CHEMICAL COMPOSITION  
A solid composition comprising nanoparticles of atovaquone dispersed within one or more carrier materials, wherein the atovaquone is present in an amount of at least 10 wt %. Also described is an...
US20190321297 SUSTAINED DELIVERY OF THERAPEUTIC AGENTS TO AN EYE COMPARTMENT  
Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing...
10450609 Quantitative multiplex methylation specific PCR method—cMethDNA, reagents, and its use  
The cMethDNA method of the present invention is a novel modification of the QM-MSP method (U.S. Pat. No. 8,062,849), specifically intended to quantitatively detect tumor DNA (or other circulating...
10448956 Computer-assisted planning and execution system  
A method for computer-assisted planning of a transplant surgery is provided. The method includes obtaining a computer-readable representation of a donor and recipient skeletal fragment;...
10448901 Methods for evaluating regional cardiac function and dyssynchrony from a dynamic imaging modality using endocardial motion  
An embodiment in accordance with the present invention provides a method and system for evaluating regional cardiac function and dyssynchrony from an imaging modality using the motion of...
10448860 System and method for bioelectric localization and navigation of interventional medical devices  
A system and method for tracking a position of an interventional medical device configured to be deployed into a subject during a medical procedure. An anatomical dataset of the subject is...
US20190320015 NETWORK-ATTACK-RESILIENT INTRUSION-TOLERANT SCADA ARCHITECTURE  
The present invention generally relates to network-attack-resilient intrusion-tolerant Supervisory Control and Data Acquisition (SCADA) systems. Some implementations utilize redundant,...
US20190316124 SEMAPHORIN 3D AND PLEXIN D1 AS THERAPEUTIC TARGETS FOR PANCREATIC CANCER TREATMENT  
The invention features compositions and methods for treating and preventing pancreatic cancer.
US20190315784 PRODRUGS OF GLUTAMINE ANALOGS  
The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds...
US20190315783 PRODRUGS OF GLUTAMINE ANALOGS  
The disclosure provides compounds having formula (I): and the pharmaceutically acceptable salts thereof, wherein R1, R2, R2′, and X are as defined as set forth in the specification. Compounds...
US20190314531 TUMOR AND IMMUNE CELL IMAGING BASED ON PD-L1 EXPRESSION  
The presently disclosed subject matter provides compositions, kits, and methods comprising imaging agents that can detect Programmed Death Ligand 1 (PD-L1). The presently disclosed imaging agents...
US20190314521 COMPOSITIONS AND METHODS COMPRISING IMPROVEMENTS OF CRISPR GUIDE RNAS USING THE H1 PROMOTER  
The presently disclosed subject matter provides compositions and methods comprising improvements of a CRISPR system (e.g. CRISPR associated (Cas) 9 (CRISPR-Cas9, non-Cas9 CRISPR systems). Such...
US20190314416 METHODS FOR PROMOTING HEALING OF TISSUE  
A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the...
US20190314344 METHODS OF TREATING INFLAMMATORY BOWEL DISEASE WITH AMD3100 AND TACROLIMUS  
The present invention relates to the field of inflammatory bowel disease. In one aspect, the present invention provides methods for treating inflammatory bowel disease in a patient comprising...
10442860 Compositions and methods for targeted immunomodulatory antibodies and fusion proteins  
The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are...
10441787 Neuromodulation device  
The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus...
10441760 Self-actuating chemomechanical devices for delivery and extended release of therapeutic agents in the gastrointestinal tract  
The presently disclosed delivery systems utilize microtools, also referred to as theragrippers, to deliver a drug or other therapeutic agent to targeted tissue. More particularly, the drug...
10441549 Methods of preparing polyelectrolyte complex nanoparticles  
The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more...
10441443 Multi-modal neural interfacing for prosthetic devices  
Methods and systems to interface between physiological devices and a prosthetic device, including to receive a plurality of types of physiological activity signals from a user, decode a user...
US20190311505 System And Method For Artifact Reduction In An Image  
Selected artifacts, which may be based on distortions or selected attenuation features, may be reduced or removed from a reconstructed image. Various artifacts may occur due to the presence of a...
US20190310265 CITRULLINATED BRAIN AND NEUROLOGICAL PROTEINS AS BIOMARKERS OF BRAIN INJURY OR NEURODEGENERATION  
The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment,...
US20190309314 YEAST SYNTHETIC BIOLOGY PLATFORM FOR IDENTIFYING SHIKIMATE PATHWAY ENZYME INHIBITORS  
Provided are compositions and methods for compound discovery. Modified yeast that have their endogenous yeast shikimate pathway disrupted or deleted, and replaced with homologous pathway genes...
US20190308190 NON-INVASIVE CANCER DETECTION AND ANALYSIS BY SINGLE-MOLECULE IMAGING  
Described are chips for detecting a target in a sample including a microfluidic flow chamber comprising one or more flow channels having a capture surface and at least one micromixer. Described...
US20190307784 APTAMERS REDUCE SICKLE HEMOGLOBIN POLYMERIZATION  
The presently disclosed subject matter provides methods for reducing sickling of an erythrocyte comprising sickle hemoglobin (HbS) by introducing polynucleotide aptamers into the erythrocyte. The...
10440055 Apparatus and method for implementing network deception  
An example apparatus configured to perform network deception may include processing circuitry configured to generate virtual instances of decoy resources residing within a defined host network for...