Patents and Patent Applications from Johns Hopkins University


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US20180269645 HIGH ENERGY FIBER LASER AMPLIFIER WITH REDUCED OPTICAL LINEWIDTH  
Example apparatuses and methods are provided that improve laser performance or decrease the frequency or severity of the occurrence of Stimulated Brillouin scattering. One example is a laser...
US20180267067 METHODS FOR BIOANALYSIS OF 6-DIAZO-5-OXO-L-NORLEUCINE (DON) AND OTHER GLUTAMINE ANTAGONISTS  
The presently disclosed subject matter provides methods for quantifying levels of glutamine antagonists, such as 6-diazo-5-oxo-L-norleucine (DON), including such glutamine antagonists resulting...
US20180265456 PERSONALIZED, ALLOGENEIC CELL THERAPY OF CANCER  
Resins are provided including bisphenol M diphthalonitrile ether resin or bisphenol P diphthalonitrile either resin. Compositions are also provided, including a primary amine curative and the...
US20180264143 SALICYLIC ACID-BASED POLYMERIC CEST CONTRAST AGENTS TARGETING PROSTATE-SPECIFIC MEMBRANE ANTIGEN AND USES THEREOF  
Salicylic acid-based polymeric CEST contrast agents targeting prostate-specific membrane antigen, pharmaceutical composition comprising the same and methods of use thereof are disclosed.
US20180264135 COMPOSITIONS AND METHODS FOR ENHANCING TRANSPORT THROUGH MUCUS  
The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.
US20180264130 TARGETING THE M2-TUMOR ASSOCIATED MACROPHAGE FOR CANCER THERAPY  
The present invention features methods of directly targeting specific cell surface receptors on the M2 macrophage for antibody or nanoparticle directed therapy.
US20180263919 THERAPEUTIC ELECTROSPUN FIBER COMPOSITIONS  
The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents...
10076601 Implanted tube and external interface for saline or drug delivery to the paranasal sinuses  
An embodiment in accordance with the present invention provides an implanted catheter and an external device that the patient uses to inject a therapeutic into the implanted tube. The implanted...
10076263 System and method for blood brain permeability imaging (BBPI) using dynamic susceptibility contrast magnetic resonance imaging  
A system and method for generating dynamic susceptibility contrast information from medical imaging data acquired using a magnetic resonance imaging (MRI) system and from a subject having received...
US20180259518 METHODS FOR IDENTIFYING PATTERNS OF IFN INDUCED EXPRESSION AND USE IN DIAGNOSIS, MONITORING AND THERAPY  
The present inventors identified a subpopulation of genes induced by type I and type II IFNs in a human submandibular gland (HSG) epithelial cell line. Unexpectedly, it was found that the majority...
US20180259130 PASSIVE DIODE-LIKE DEVICE FOR FLUIDS  
The present invention is directed to an improved fluid diode using topology optimization with Finite Element Method (FEM). Topology optimization as a flexible optimization method has been extended...
US20180258490 ASSAYING OVARIAN CYST FLUID  
A diagnostic test for ovarian cysts is based on the detection of mutations characteristic of the most common neoplasms giving rise to these lesions. With this test, tumor-specific mutations were...
US20180256745 BIOMIMETIC ARTIFICIAL CELLS: ANISOTROPIC SUPPORTED LIPID BILAYERS ON BIODEGRADABLE MICRO AND NANOPARTICLES FOR SPATIALLY DYNAMIC SURFACE BIOMOLECULE PRESENTATION  
The presently disclosed subject matter provides compositions and methods for using a non-spherical biomimetic artificial cell comprising a three-dimensional microparticle or nanoparticle having an...
US20180256683 Compositions and Methods for Treating Heart Failure  
The present invention relates to compositions and methods for the treatment of heart failure.
US20180256680 A H3T3A MUTANT PROTEIN EFFICIENTLY REDUCES H3T3P AND CAUSES INCREASED CELL DEATH OF RAPIDLY DIVIDING CELLS  
The invention features compositions comprising an H3T3A mutant protein. Described herein are methods of inducing cell death in a rapidly dividing cell comprising contacting a rapidly dividing cell...
US20180256568 Methods and Compositions for Killing Senescent Cells and for Treating Senescence-Associated Diseases and Disorders  
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases...
US20180256508 NANOCRYSTALS, COMPOSITIONS, AND METHODS THAT AID PARTICLE TRANSPORT IN MUCUS  
Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP)...
US20180256497 COMPOSITIONS AND METHODS FOR OPHTHALMIC AND/OR OTHER APPLICATIONS  
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other...
10074173 Methods and systems for analyzing anatomy from multiple granularity levels  
A method, computer system and computer readable storage medium for searching for one or more images having a region of interest similar to the region of a subject, including: receiving imaging...
US20180253994 SYSTEMS FOR QUANTIFYING CLINICAL SKILL  
A system quantifying clinical skill of a user, comprising: collecting data relating to a surgical task done by a user using a surgical device; comparing the data for the surgical task to other...
US20180251550 T Cell Regulation  
Combinations of anti-cancer antibodies and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The inhibitory antibodies may be generated in an animal by injection of...
US20180250320 COMPOSITIONS AND METHODS FOR TREATING SOLID TUMORS  
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods useful for treating solid tumors. In a specific embodiment, a...
US20180249906 FAST X-Y AXIS BRIGHT PUPIL TRACKER  
The present invention provides for very fast detection of gaze direction using retro-reflected light from the ocular fundus that is cost-efficient, small, and portable. These eye trackers are...
10064591 System, method and computer readable medium for preview of low-dose x-ray projection and tomographic images  
A novel method for simulating radiation dose reduction that enables previews of low-dose x-ray projection images, low-dose computed tomography images and/or cone-beam CT images. Given an existing...
US20180248101 Thermoelectric Generator  
An electric generator device is provided that includes a thermoelectric array, a base plate, and an electric power output. The thermoelectric array may include a hot side portion and a cold side...
US20180246095 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING LYME DISEASE  
The present invention relates to compositions and methods of diagnosing and treating Lyme disease.
US20180246082 ASSAY TO DIAGNOSE AND TREAT DISORDERS OF THE ALTERNATIVE PATHWAY OF COMPLEMENT ACTIVATION  
The present invention relates generally to the field of disorders of complement activation. More specifically, the present invention provides methods and compositions useful for diagnosing and...
US20180244705 PRODRUGS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITOR  
Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.
US20180244610 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS  
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
US20180243481 FIBER-HYDROGEL COMPOSITE SURGICAL MESHES FOR TISSUE REPAIR  
The presently disclosed composition and methods are provided for a hydrogel or nanofiber-hydrogel composite integrated with a surgical scaffold or mesh. A surgical scaffold device comprised of...
US20180243480 MESENCHYMAL CELL-BINDING COMPOSITE MATERIAL FOR TISSUE RESTORATION  
The presently disclosed composition and methods are provided for a nanofiber-hydrogel composite containing adipose cell binding moieties. A method for healing a soft tissue defect can include...
US20180243131 Reservoir Device for Intraocular Drug Delivery  
A delivery device that allows for the sustained release of an agent, particularly useful for the sustained release of a therapeutic agent to limited access regions, such as the posterior chamber...
US20180242960 METHOD AND DEVICE FOR TISSUE ACQUISITION OR CLOSURE  
The present disclosure provides a device and methods for acquiring tissue within a lumen or for closure of bodily openings.
10063320 Apparatus and method for implementing a photonic radio front end  
Apparatuses and methods for implementing a photonic radio front end are provided. An example apparatus may include a photonic comb filter configured to generate a photonic pulse train at a...
10059927 Compositions and methods for controlling microbial growth  
Provided are modified microorganisms which are modified such that their growth can be controlled using exogenously provided compounds. The microorganisms can be modified by genetic alterations...
10059702 Inhibitors of LC3/ATG3 interaction and their use in the treatment of cancer  
The present inventors discovered that the molecule pyridinylthiazolamine (PTA) specifically prevents the protein-protein interaction of hLC3 with hAtg3 in vitro and in cell based assays. The...
10058511 Nanocrystals, compositions, and methods that aid particle transport in mucus  
Nanocrystals, compositions, and methods that aid particle transport in mucus are provided. In some embodiments, the compositions and methods involve making mucus-penetrating particles (MPP)...
10058390 Devices, systems and methods for minimally invasive surgery of the throat and other portions of mammalian body  
Featured are systems, devices and apparatuses for use in minimally invasive surgical, diagnostic or therapeutic methods and/or techniques, in particular methods and/or techniques for a mammalian...
US20180236127 DEVICES FOR AND METHODS OF TREATMENT OF METABOLIC SYNDROMES  
Devices for and methods of treatment of metabolic syndromes are disclosed. Namely, the presently disclosed devices and methods are provided for affecting the function of the gastrointestinal...
US20180236112 HOMOMULTIVALENT AND HETEROMULTIVALENT INHIBITORS OF PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) AND USES THEREOF  
The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of PSMA inhibitors. The compounds and their...
US20180236110 PSMA-BINDING AGENTS AND USES THEREOF  
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds,...
US20180235994 COMPOSITIONS AND METHODS FOR TREATING VASCULAR MALFORMATION AND RELATED CONDITIONS  
In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L...
10053729 Rapid aneuploidy detection  
The present disclosure relates to methods for testing a human for aneuploidy. In some aspects, a plurality of chromosomal sequences in a DNA sample from a human are amplified with a single pair of...
10053243 Release system for deploying satellites  
A release system may include a space vehicle separation plate operably coupled to a space vehicle, a launch vehicle adaptor plate operably coupled to a launch vehicle capable of carrying the space...
10052482 Spatial fitting by percept location tracking  
The present invention is an improved spatial fitting and training system for a visual prosthesis. The system of the present invention maps projected locations of percepts, where a person perceives...
US20180233925 CONSTANT POWER ADAPTIVE POWER SYSTEM  
An adaptive power system for powering a dynamically changing load may include an energy storage device, a bi-directional current source, and compensation circuitry. The bi-directional current...
US20180231665 APPARATUS FOR TRANSLATION OF GPS SIGNALS TO FACILITATE ASSET TRACKING  
A method for facilitating real time tracking of an airborne asset via downlink of GPS signals that are usable for determining asset location information from the asset to a ground station may...
US20180230550 Personalized Tumor Biomarkers  
Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. We have developed a method, called personalized analysis of rearranged ends (PARE),...
US20180228863 COMPOSITION AND METHOD FOR TREATMENT OF METABOLIC DISORDERS  
The present invention provides compositions and methods for treatment of metabolic syndromes. Namely, the presently disclosed compositions and methods are provided for affecting the function of...
US20180228599 TISSUE-DERIVED SCAFFOLDS FOR CORNEAL RECONSTRUCTION  
The present invention relates to methods for treating a corneal disease such as, for example, corneal blindness, or the refractive power of a cornea by generating a vitrified decellularized...