Patents and Patent Applications from Johns Hopkins University


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US20180043162 NEUROMODULATION DEVICE  
The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus...
US20180043003 REAGENTS AND METHODS FOR IDENTIFYING, ENRICHING, AND/OR EXPANDING ANTIGEN-SPECIFIC T CELLS  
Antigen-specific T cells, including nave T cells, and including rare precursor cells are enriched and expanded in culture. Enrichment and expansion provides a platform for more effective...
US20180042680 INTERACTIVE USER INTERFACES FOR MINIMALLY INVASIVE TELESURGICAL SYSTEMS  
In one embodiment of the invention, a a minimally invasive surgical system is disclosed. The system configured to capture and display camera images of a surgical site on at least one display...
US20180042494 DEVICE AND METHOD TO MEASURE VENTRICULAR ARTERIAL COUPLING AND VASCULAR PERFORMANCE  
A device for measuring a ventricular-arterial coupling of a subject includes first and second inputs. The first input receives signals from a plurality of electrocardiogram sensors that are...
US20180042466 COMPACT ENDOSCOPE DESIGN FOR THREE-DIMENSIONAL SURGICAL GUIDANCE  
The present invention is directed to endoscopic structure illumination to provide simple, inexpensive 3D endoscopic technique to conduct high resolution 3D imagery for use in surgical guidance...
9891224 Biomarkers for aggressive prostate cancer  
The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing aggressive prostate cancer. In one embodiment, a...
9890361 Methods for increasing the infectivity of viruses utilizing alkyne-modified fatty acids  
Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the...
9889208 Lipid-based drug carriers for rapid penetration through mucus linings  
Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and...
9888876 Method of analyzing multi-sequence MRI data for analysing brain abnormalities in a subject  
The present invention, referred to as Oasis is Automated Statistical Inference for Segmentation (OASIS), is a fully automated and robust statistical method for cross-sectional MS lesion...
9888869 Neural block determination  
An apparatus for neural block determination is provided including processing circuitry configured to receive muscle movement measurements, analyze the muscle movement measurements in a frequency...
US20180038875 METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION, AND TREATMENT OF NEUROLOGICAL DISORDERS AND DISEASES  
Described herein are methods of identifying a mammal having a neurological disease or disorder, such as AD or MCI, or at risk for developing a neurological disease or disorder, such as AD or MCI....
US20180037954 A DNA METHYLATION AND GENOTYPE SPECIFIC BIOMARKER FOR PREDICTING POST-TRAUMATIC STRESS DISORDER  
The present invention relates to the field of biomarkers. More specifically, the present invention relates to the use of biomarkers to predict post-traumatic stress disorder (PTSD). In one...
US20180037621 COMPOSITIONS AND METHODS FOR ENHANCING AN IMMUNE RESPONSE  
The disclosure features compounds comprising an antigen portion, a soluble Major Histocompatibility Complex (MHC) molecule portion (e.g., all or an antigen-binding portion of a soluble MHC class I...
US20180036549 DEVICE FOR MAGNETIC STIMULATION OF THE VESTIBULAR SYSTEM  
The present invention is directed to a magnetic vestibular stimulation (MVS) system for rehabilitation of subjects with vestibular and balance disorders. The magnetic vestibular stimulation system...
US20180036354 CVS TRANSPLANTATION FOR TREATMENT OF BACTERIAL VAGINOSIS  
Methods and materials for treating bacterial vaginosis (“BV”) are provided. Cervicovaginal secretions (“CVS”) from a woman with Lactobacillus crispatus-dominated (>50%) vaginal microbiota is...
US20180036301 LOCAL DELIVERY FORMS OF ACRIFLAVINE FOR TREATING TUMORS  
Local delivery formulations of the antineoplastic and microbicide agent acriflavine, and methods of making and using thereof are significantly more efficacious at increasing the median survival of...
US20180036264 TARGETING LIVER NUCLEAR RECEPTORS AS A TREATMENT FOR WILSON DISEASE  
The present invention relates to the field of Wilson Disease. More specifically, the present invention provides methods and compositions useful for treating Wilson Disease by targeting liver...
US20180036175 Object Recognition and Presentation for the Visually Impaired  
Apparatuses, systems, and methods for object recognition and presentation are provided. An example apparatus may include a camera, an assistance feedback device, an input device, and processing...
9885682 Biosensor systems and related methods for detecting analytes in aqueous and biological environments  
Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may...
9884132 Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (PSMA) and uses thereof  
The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of PSMA inhibitors. The compounds and their...
9884118 Multicomponent degradable cationic polymers  
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation...
US20180031576 A NOVEL NERVOUS SYSTEM-SPECIFIC TRANSMEMBRANE PROTEASOME COMPLEX THAT MODULATES NEURONAL SIGNALING THROUGH EXTRACELLULAR SIGNALING VIA BRAIN ACTIVITY PEPTIDES  
The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation...
US20180030086 METHODS AND SYSTEMS FOR GENERATING, VALIDATING AND USING MONOCLONAL ANTIBODIES  
Provided herein is a library of antibodies, wherein the library of antibodies can comprise a plurality of monoclonal, monospecific, or immunoprecipitating antibodies. Also provided herein is a...
US20180028687 EXTRACELLULAR VESICLES FOR AGENT DELIVERY  
The present invention relates to the field of extracellular vesicles. More specifically, the present invention provides methods and compositions for using extracellular vesicles as a vector for...
US20180028577 BACTERIA OVER-EXPRESSING C-DI-AMP AND THERAPEUTIC METHODS  
The present invention includes the discovery of a strain of Mycobacterium comprising an expression vector encoding a di-adenylate cyclase enzyme. The Mycobacterium is selected from the group...
US20180028455 PEPTIDE/PARTICLE DELIVERY SYSTEMS  
Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including...
US20180028165 METHOD AND DEVICE FOR STATISTICAL TISSUE SAMPLING USING MICRODEVICES  
The present invention utilizes tetherless microtools to biopsy tissue. The invention provides a device and method for deployment and retrieval of tetherless microtools. The size of the microtools...
US20180028127 EXTREMITY IMAGING APPARATUS FOR CONE BEAM COMPUTED TOMOGRAPHY  
An apparatus for cone beam computed tomography can include a support structure, a scanner assembly coupled to the support structure for controlled movement in at least x, y and z orientations, the...
9878005 Method of promoting wound healing with hyodxia-induced mitogenic factor  
We found that FIZZ1/RELMα is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELMα was located in the pulmonary vasculature, bronchial epithelial cells, and type II...
9877978 Compositions comprising NDGA derivatives and sorafenib and their use in treatment of cancer  
The present invention provides pharmaceutical compositions comprising derivatives of NDGA, including M4N (tetra-O-methyl nordihydroguaiaretic acid) and sorafenib and their use in the inhibition...
9877788 MRI-safe robot for transrectal prostate biopsy  
An MRI safe robot for guiding transrectal prostate biopsy comprises a support arm, a robot body operatively connected to the support arm and a transrectal biopsy device operatively connected to...
US20180021435 HYPOTONIC HYDROGEL FORMULATIONS FOR ENHANCED TRANSPORT OF ACTIVE AGENTS AT MUCOSAL SURFACES  
Hypotonic formulations of hydrogel forming polymers, preferably poloxamers, have been developed for enhanced delivery through mucosa of therapeutic, diagnostic, prophylactic or other agents, to...
US20180021310 MEBENDAZOLE POLYMORPH FOR TREATEMENT AND PREVENTION OF TUMORS  
Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy. Three polymorphs of mebendazole exist, but the relative polymorph...
US20180021306 INHIBITION OF YAP FOR BREAKING TUMOR IMMUNE TOLERANCE  
Yes-associated protein (Yap), a downstream co-activator of the Hippo pathway, is highly expressed in the Treg cell subset, and is critical to maintain its suppressive activity. Originally...
US20180020985 OPTICAL IMAGING SYSTEM AND METHOD OF MAKING AND USING THE SAME  
An optical imaging system for interfacing with a separate examination apparatus and methods of making and using the same are disclosed. The optical imaging system can include an imaging housing...
9873917 Oligodendroglioma drive genes  
Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19,...
9873661 Small molecule malarial Aldolase-TRAP enhancers and glideosome inhibitors  
In one aspect, the present invention relates to a method of identifying compounds useful in modifying the activity of Aldolase. The method includes providing a first model comprising Aldolase or...
9873198 Active vibration damping device  
According to some embodiments of the present invention, a cooperatively-controlled robot includes a robotic actuator assembly comprising a tool holder and a force sensor. The...
9872692 Motion-compensated micro-forceps system and method  
A motion-compensated micro-forceps system, including a manually-operable micro-forceps assembly having a plurality of moveable grasping elements; a motor assembly operatively connected to the...
US20180015153 COMPOUNDS AND METHODS FOR TREATMENT AND PREVENTION OF FLAVIVIRUS INFECTION  
The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating...
US20180015109 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION  
The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an acetylcholinesterase inhibitor...
9870620 Non-linear associator and motion discriminator  
An image analyzer includes processing circuitry that receives at least one image having a first set of bins and a second set of bins, shifts the first or second set of bins by a number of bins...
9867668 Environment property estimation and graphical display  
A surgical robot including an imaging system comprising at least one camera, a processor in communication with the imaging system, a manipulation system in communication with the processor, and a...
US20180010183 METHODS FOR CHARACTERIZING AND TREATING COGNITIVE IMPAIRMENT IN AGING AND DISEASE  
This invention provides methods for identifying genes associated with cognitive impairment and for identifying compounds useful in the treatment of cognitive impairment. The methods can in...
US20180009859 PHARMACOLOGICAL MODULATORS OF GABAA RECEPTORS AND THEIR USE  
The present invention provides polypeptides and their variants and derivatives which modulate GABAA receptor function at nanomolar quantities by binding to the α+/β− subunit interface, as well as...
US20180009767 PSMA TARGETED FLUORESCENT AGENTS FOR IMAGE GUIDED SURGERY  
Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate...
US20180008718 COMPOSITIONS FOR THE SUSTAINED RELEASE OF ANTI-GLAUCOMA AGENTS TO CONTROL INTRAOCULAR PRESSURE  
Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the...
US20180008668 ALBUMIN-PROAEROLYSIN PRODRUGS  
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for treating cancer using albumin-proaerolysin prodrugs....
US20180008541 Cyclodextrin Compositions Encapsulating a Selective ATP Inhibitor and Uses Thereof  
The invention provides compositions comprising cyclodextrins encapsulating a selective ATP inhibitor, as well as uses thereof.
9862699 Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors  
The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds...