Patents and Patent Applications from Johns Hopkins University


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US20170348307 METHODS AND COMPOSITIONS FOR KILLING SENESCENT CELLS AND FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS  
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases...
9838800 PBLG based planar microphones  
A piezoelectric, poly (γ-benzyl-α,L-glutamate) (“PBLG”) planar microphone, and method for construction thereof, are disclosed. The microphone includes at least a polyester film, a piezoelectric,...
9835642 High speed image processing device  
A scene measurement assembly includes a first illuminator assembly having multiple grids of coplanar illuminators, a first system-on-chip light sensing device having sensors disposed to receive...
9833248 Bone harvesting  
Methods and devices for harvesting cancellous bone are disclosed. The bone-harvesting device may include a cannula and a bone receptacle in communication with the cannula, wherein the cannula...
US20170342599 Electrospinning Aramid Nanofibers  
Example methods and articles of manufacture related to electrospun aramid nanofibers are provided. One example method may include forming a resultant solution by reacting a solution of aramids...
US20170342399 CHAOTROPE- AND VOLATILE-FREE METHOD FOR PURIFYING NUCLEIC ACIDS FROM PLASMA  
The presently disclosed subject matter provides methods and kits for purifying nucleic acids from blood plasma using a functionalized solid phase comprising a silica or polymer backbone and...
US20170340709 METHODS OF TREATMENT USING STEM CELL MOBILIZERS  
The present invention relates to the field of stem cells. In one aspect, the present invention provides methods of treating a subject with acute liver injury comprising administering to the...
US20170340595 Compositions and Methods for Treating Autism Spectrum Disorders  
The instant disclosure features, among other things, compositions and methods for treating an autism spectrum disorder in a human. The compositions comprise an effective amount of: (1) an...
9827191 Compositions and methods for ophthalmic and/or other applications  
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other...
9826953 Integration of quantitative calibration systems in computed tomography scanners  
An embodiment in accordance with the present invention provides a device and method for a quantitatively calibrated computed tomography scanner. The device includes a gantry configured for...
US20170336399 NOVEL METHODS AND DEVICES FOR HIGH-THROUGHPUT QUANTIFICATION, DETECTION AND TEMPORAL PROFILING OF CELLULAR SECRETIONS, AND COMPOSITIONS IDENTIFIED USING SAME  
The present invention relates to the unexpected discovery of methods and devices that can be used for high-throughput precise quantification, detection and/or temporal profiling of cellular...
US20170336387 AGGREGATION-ASSISTED SEPARATION OF PLASMA FROM WHOLE BLOOD  
Methods for separating blood plasma from whole blood in the absence of performing centrifugation are provided. The method combines mechanical filtration and blood cell aggregation and is adapted...
US20170335442 METHOD FOR FORMING BINDER-FREE REFRACTORY CARBIDE, NITRIDE AND BORIDE COATINGS WITH A CONTROLLED POROSITY  
The present invention is directed to methods for formation of refractory carbide, nitride, and boride coatings without use of a binding agent. The present invention is directed to methods of...
US20170333576 NEW SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY  
Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express...
US20170333375 Treatment of Retinitis Pigmentosa with N-Acetylcysteine Amide  
The present invention includes a method for the treatment of retinitis pigmentosa in a human that comprises adminisering to the human a therapeutically effective amount of N-acetylcysteine amide...
US20170332929 Method and System to Access Inapparent Conduction Abnormalities to Identify Risk of Ventricular Tachycardia  
A method and system for determining a patient's risk of ventricular tachycardia are disclosed. The method includes receiving ECG signals from a patient and filtering the collected ECG signals to...
9825701 Free space optical communication  
An optical communications beacon receiver including a camera for capturing a plurality of beacon images. The plurality of beacon images includes a beacon signal transmitted from a beacon...
9824786 Compact particle sensor  
An energy sensor is provided including a collimator comprising a plurality of sensor apertures aligned in a plurality of directions configured to allow passage of an energetic particle or photon...
9823202 Differential phase contrast X-ray imaging system and components  
A differential phase contrast X-ray imaging system includes an X-ray illumination system, a beam splitter arranged in an optical path of the X-ray illumination system, and a detection system...
9822392 Co-translational activation of a transcription factor by proteolytic cleavage and methods of use  
A method for measuring expression of autoregulatory molecules within living cells is provided. An autoregulatory molecule and marker construct is expressed in vivo, where the marker is cleaved...
US20170327898 OVARIAN CARCINOMA DETECTION AND PROPHYLAXIS  
The evolutionary origin of high-grade serous ovarian carcinoma remains largely unknown. The vast majority of tumor-specific genomic alterations from ovarian cancers are present in fallopian tube...
US20170327543 POLYIONIC PAPILLOMA VIRUS-LIKE PARTICLE (VLP) VACCINES  
The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (VLP) vaccines. In one embodiment, a...
US20170326136 Treatment of Pain  
This disclosure provides a technology for managing the sensation of pain in a subject in need thereof. Treatment methods according to this invention include administering to the subject a...
9816995 Biomarker for ovarian cancer CTAP3-related proteins  
The present invention provides a protein-based biomarker that is useful in qualifying ovarian cancer status in a patient. In particular, the biomarker of this invention is useful to classify a...
9815206 Surgical system user interface using cooperatively-controlled robot  
According to some embodiments of the present invention, a cooperatively controlled robot includes a robotic actuator assembly comprising a tool holder and a force sensor, a control system adapted...
9814731 Method for the induction of phase 2 related genes in a mammal comprising administering exemestane  
In addition to its potent mechanism-dependent inhibition of estrogen biosynthesis, in accordance with the embodiments of the present invention, it has now been found that exemestane has novel...
9814392 Visual tracking and annotaton of clinically important anatomical landmarks for surgical interventions  
A visual tracking and annotation system for surgical intervention includes an image acquisition and display system arranged to obtain image streams of a surgical region of interest and of a...
US20170323118 Apparatus and Method for Private Information Retrieval  
Apparatuses and methods for private information retrieval are provided. One example method may include receiving a query state machine that is an encoding of a search pattern. The query state...
US20170321278 DETECTION AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE  
Compositions useful for examining the PKD1 gene are provided. In addition, methods for detecting mutations of the PKD1 gene, which can be associated with autosomal dominant polycystic kidney...
US20170319278 SYSTEMS AND METHODS FOR ATRIAL FIBRILLATION TREATMENT AND RISK ASSESSMENT  
According to some embodiments of the invention, a method for providing an atrial fibrillation (AF) ablation treatment plan includes receiving imaging data for at least a portion of an atrial...
9812864 Adaptive power system  
An adaptive power system includes an energy source, a bidirectional current source electrically connected between the energy source, and a power distribution bus of a power distribution system....
9809864 Dual sequence-capture method for quantifying trans renal HPV DNA in urine  
Methods for the quantifying HPV Trans Renal DNA (TrDNA) from a urine sample from a subject using a dual sequence-capture approach are disclosed. The presently disclosed methods can be used to...
9808987 Cranial bone surrogate and methods of manufacture thereof  
A surrogate multilayered material and manufacturing method thereof includes a first fiber reinforced layer, the first reinforced layer including a crosslinked polymer and fibers, and a second...
9808516 Immunogenic fusion proteins for the treatment of cancer  
Provided herein are compositions and methods for eliciting an immune response in a subject. In particular, the present disclosure is directed to immunogenic fusion proteins and methods of...
US20170315138 ASSAY REAGENTS FOR A NEUROGRANIN DIAGNOSTIC KIT  
The present invention relates to the field of biomarkers. More specifically, the present invention relates to assay reagents useful in detecting neurogranin. In a specific embodiment, the present...
US20170315135 BIOMARKERS USEFUL IN THE TREATMENT OF SUBJECTS HAVING RETINITS PIGMENTOSA  
The present invention provides biomarkers of oxidative stress in subjects with Retinitis Pigmentosa and their use in identifying subjects in need of treatment and methods for staging the severity...
US20170314080 SERUM-BASED MIRNA MICROARRAY AND ITS USE IN DIAGNOSIS AND TREATMENT OF BARRETT'S ESOPHAGUS (BE) AND ESOPHAGEAL ADENOCARCINOMA (EAC)  
Robust and reliable molecular diagnostic screening tools for early detection of esophageal and gastrointestinal tract cancers and pre-cancerous lesions, such as Barrett's Esophagus, and esophageal...
US20170313775 Checkpoint Blockade and Microsatellite Instability  
Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these...
US20170312547 METHOD TO RECONSTRUCT THE 3D MAP OF THE RADIATION TREATMENT ISOCENTER OF A MEDICAL ACCELERATOR  
For the delivery of high precision radiation treatment, the accuracy with which a target is irradiated at individual gantry, collimator and patient couch orientation is traditionally verified in...
US20170311809 GENERAL B-MODE SURFACE IMAGING  
An ultrasound system includes an ultrasound transducer, an ultrasound controller structured to communicate with the ultrasound transducer, and a signal processing system structured to communicate...
9806259 Patterning devices using fluorinated compounds  
A method for producing a spatially patterned structure includes forming a layer of a material on at least a portion of a substructure of the spatially patterned structure, forming a barrier layer...
9805099 Apparatus and method for efficient identification of code similarity  
A method for identifying similarity between query samples and stored samples in an efficiently maintained reference library may include receiving a first threshold and a second threshold,...
9804975 Hardware-enforced prevention of buffer overflow  
An apparatus having processing circuitry configured to execute applications involving access to memory may include a CPU and a cache controller. The CPU may be configured to access cache memory...
9802984 Biomimetic peptide and biodegradable delivery platform for the treatment of angiogenesis- and lymphangiogenesis-dependent diseases  
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and...
US20170311101 MIDDLE EAR IMPLANT SENSOR  
A middle ear implant may include a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a...
US20170305990 TMEM100 PEPTIDES AND VARIANTS THEREOF AND THEIR USE IN TREATING OR PREVENTING DISEASES OR CONDITIONS  
The present invention features compositions of Tmem100 peptides and variants thereof, and their use in treating or preventing diseases or conditions.
US20170305847 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS  
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
US20170304214 THERAPEUTIC ELECTROSPUN FIBER COMPOSITIONS  
The instant invention provides electrospun fiber compositions comprising one or more polymers and one or more biologically active agents. In specific embodiments, the biologically active agents...
9799333 System and method for processing speech to identify keywords or other information  
A system and method are provided for performing speech processing. A system includes an audio detection system configured to receive a signal including speech and a memory having stored therein a...
9799100 Integration of T2-preparation and motion tracking in magnetic resonance imaging  
An embodiment in accordance with the present invention provides concurrent measurement of motion during T2-weighted magnetic resonance imaging. The present invention combines T2 preparation, a...