Patents and Patent Applications from Johns Hopkins University


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US20170296682 DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS  
The presently disclosed subject matter provides non-invasive methods for imaging, quantifying α7 nicotinic cholinergic receptors, and diagnosing a disease or condition associated with α7-nAChRs....
US20170296193 BIODEGRADABLE NERVE GUIDES  
The present invention is directed to the compositions and methods of preparing hydrogel-grafted nerve guides for peripheral nerve regeneration. Particularly, the present invention describes the...
9791489 High dynamic range RF power monitor  
A device with at least one channel for measuring high dynamic range, radio frequency (RF) power levels over broad-ranging duty cycles includes a power sensor circuit comprising at least one...
9790277 Anti-H7CR antibodies  
Antibodies and humanized variants thereof and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H7 counter-receptor, H7CR, and their...
US20170295337 FLEXIBLE READOUT AND SIGNAL PROCESSING IN A COMPUTATIONAL SENSOR ARRAY  
A computational sensing array includes an array of sensing elements. In each sensing element, a first signal is generated from a transducer. A second signal is produced by a collection unit in...
US20170293008 MEASUREMENT OF BLOOD VOLUME USING VELOCITY-SELECTIVE PULSE TRAINS ON MRI  
The present invention is directed to a system and method for measuring blood volume using non-contrast-enhanced magnetic resonance imaging. The method of the present invention includes a...
US20170292963 BIOMARKERS OF COGNITIVE DYSFUNCTION  
The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in...
US20170291030 SYSTEM AND METHOD FOR BRAIN STIMULATION FOR IMPROVEMENT OF MOTOR SYMPTOMS IN PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS  
An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral...
US20170290930 Light-Emitting Versions of the Monoclonal Antibody to C3D (MAB 3D29) for Imaging  
The presently disclosed subject matter provides compositions and kits comprising light-emitting versions of the monoclonal antibody to C3d (mAB 3d29) for imaging and methods of use thereof for...
9783790 Trichoplusia ni piggybac transposases with reduced integration activity  
The present invention is directed to nucleic acid and amino acid sequences of a novel piggyBac transposase enzymes created by modifying the transposase of Trichoplusia ni. The piggyBac...
9783585 Compositions and methods for increasing the expression and signalling of proteins on cell surfaces  
The present invention relates to the field of protein expression. More specifically, the present invention provides compositions and methods for increasing the expression and signaling of proteins...
9783577 Hybrid cyclic libraries and screens thereof  
Provided are novel types of hybrid cyclic libraries that contain a known protein binding domain of a natural product. Also provided are synthetic methods to make such libraries and methods for the...
9782175 Systems, methods and apparatuses for real-time anastomosis guidance and surgical evaluation using optical coherence tomography  
A surgical evaluation and guidance system for use in extravacular evaluation and guidance of fluid vessel surgeries, includes an optical coherence tomography engine; a vessel probe optically...
9782068 System for diagnosis and therapy of gaze stability  
A system to improve vestibulo-ocular reflex (VOR) includes a display device; a head motion detector, the head motion detector being configured to detect at least one of a first angular rotational...
US20170288114 THERMOELECTRIC POLYMER COMPOSITES  
An embodiment of the present disclosure is directed to a thermoelectric polymer composite. The composite comprises: at least one polymer selected from semiconducting polymers and conducting...
US20170283384 PSMA TARGETED FLUORESCENT AGENTS FOR IMAGE GUIDED SURGERY  
Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate...
US20170281579 COMPOSITIONS AND METHODS FOR TREATING REFRACTORY SEIZURES  
The present invention relates to the field of seizures. More specifically, the present invention provides compositions and methods for treating refractory seizures in neonates. In one embodiment,...
US20170281541 LIPOSOME-BASED MUCUS-PENETRATING PARTICLES FOR MUCOSAL DELIVERY  
Liposome-based mucus-penetrating particles (MPP) capable of loading hydrophilic agents including therapeutic, prophylactic and diagnostic agents such as the diaCEST MRI contrast agent barbituric...
US20170281463 ECG Artifact Reduction System  
An ECG signal processing system which removes the CPR-induced artifact from measured ECG signals obtained during the administration of CPR.
US20170280730 COMPOSITIONS AND METHODS USEFUL FOR THE PREVENTION OF MALARIA AND DENGUE VIRUS TRANSMISSION  
The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of...
9777266 Methods for efficient, expansive, user-defined DNA mutagenesis  
Methods for the creation of one or more user-defined mutations that can be located anywhere in a target sequence, such as in a gene are disclosed. These methods can be used on a single-stranded or...
9776977 PSMA-targeting compounds and uses thereof  
Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
9776963 Small molecule CD4 mimetics and uses thereof  
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl,...
9776860 Method of carbon dioxide-free hydrogen production from hydrocarbon decomposition over metal salts  
A process to decompose methane into carbon (graphitic powder) and hydrogen (H2 gas) without secondary production of carbon dioxide, employing a cycle in which a secondary chemical is recycled and...
9775903 1-deoxy analogs of 1,25-dihydroxyvitamin D3 compounds  
This present disclosure is directed to novel prodrugs of activated vitamin D3 compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the...
9775506 System and method for detecting and classifying severity of retinal disease  
A method of detecting, and classifying severity of, a retinal disease using retinal images includes at least one of receiving, retrieving or generating reference data that includes information...
US20170276742 Sterile RF Coils For MR Imaging Systems  
Sterile RF coil arrangements for use in magnetic resonance imaging are provided. The sterile coil arrangements can be formed by spraying or coating a curable liquid onto an RF coil housing and...
US20170276688 ANTI-HIMF ANTIBODIES TO TREAT LUNG DISEASES  
Hypoxia induced mitogenic factor (HIMF) is a member of the “found in inflammatory zone” (FIZZ)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in the...
US20170276687 COMPOSITIONS AND METHODS FOR DETECTING ANTI-ENDOTHELIAL CELL ANTIBODIES IN ALLOGRAFT REJECTION  
Provided herein are methods, compositions, and kits for diagnosing allograft rejection of organ transplants by identifying the presence of anti-endothelial cell antibodies. Such methods and...
US20170276669 PRECISE ESTIMATION OF GLOMERULAR FILTRATION RATE FROM MULTIPLE BIOMARKERS  
The present invention relates to the field of nephrology. More specifically, the present invention provides methods and compositions useful for more precisely estimating glomerular filtration rate...
US20170275705 BIOMARKERS USEFUL FOR DETERMINING RESPONSE TO PD-1 BLOCKADE THERAPY  
PD-L1 expression by tumor cells prior to treatment correlates highly with response to anti-PD-1 and anti-PD-L1 therapy (e.g., nivolumab (Bristol-Myers Squibb), pembrolizumab (Merck)) and...
US20170275673 METHODS AND COMPOSITIONS RELATED TO PROSTATE CANCER THERAPEUTICS  
Disclosed herein are compositions and methods for detecting biological molecules and biomarkers associated with prostate cancer. Disclosed herein are compositions and methods for detecting...
US20170274102 POST-SURGICAL IMAGING MARKER  
A marker for imaging includes a bio-dissolvable material and a contrast agent configured to provide contrast during an imaging procedure. A method can include forming a marker for imaging from a...
US20170273901 SUNITINIB FORMULATIONS AND METHODS FOR USE THEREOF IN TREATMENT OF OCULAR DISORDERS  
Methods for increasing the encapsulation or incorporation of Sunitinib into polymeric matrices have been developed. The resulting formulations provide for more sustained controlled release of...
US20170273797 COMPUTER-ASSISTED CRANIOPLASTY  
Provided is a surgical method. The method includes detecting a location of a reference unit having a trackable element with a detector, the detector configured to provide at least one signal...
9773540 Skyrmion based universal memory operated by electric current  
A method for generating a skyrmion, comprising: depositing a vertical metallic nanopillar electrode on a first side of a helimagnetic thin film, the helimagnetic thin film having a contact on a...
9771592 Methods and compositions for treating or preventing pruritis  
The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
9771335 Derivatives of rufinamide and their use in inhibtion of the activation of human voltage-gated sodium channels  
The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons. Pharmaceutical compositions comprising...
9771331 Methods of identifying neuroprotective compounds for retinal ganglion cells  
Neuroprotective compounds for treating optic neuropathies and screening methods for identifying neuroprotective compounds.
9770828 Teleoperative-cooperative robotic system  
A combined teleoperative-cooperative controllable robotic system includes a robotic actuator assembly, a control system adapted to communicate with the robotic actuator assembly, and a...
9770467 Compositions and methods for cancer immunotherapy  
The present invention provides a combination therapy which relies on a small molecule immune stimulator—cyclic-di-nucleotide (CDN)—that activates DCs via a recently discovered cytoplasmic receptor...
US20170271647 HIGH ENERGY DENSITY LI-ION BATTERY ELECTRODE MATERIALS AND CELLS  
A method of preparing a high capacity nanocomposite cathode of FeF3 in carbon pores may include preparing a nanoporous carbon precursor, employing electrochemistry or solution chemistry deposition...
US20170269174 System And Method For Real-Time MRI-Guided Object Navigation  
A magnetic resonance method and system are provided for magnetic resonance (MR) image-guided insertion of an object into a biological tissue along a predetermined trajectory. The trajectory...
US20170269106 CIRCULATING PULMONARY HYPERTENSION BIOMARKER  
Methods and kits for determining, predicting, or diagnosing pulmonary artery hypertension (PAH) and for determining the efficacy of PAH therapy using biomarkers are provided.
US20170269075 BIOMARKERS PREDICTIVE OF LUPUS PROGRESSION AND USES THEREOF  
Methods, systems and kits to detect and/or quantify lupus and disease progression in a subject having, or at risk of having, lupus are disclosed.
US20170268063 METHODS FOR IDENTIFYING ANDROGEN RECEPTOR SPLICE VARIANTS IN SUBJECTS HAVING CASTRATION RESISTANT PROSTATE CANCER  
Methods of the present disclosure provide for detection of mutations and splice variants of the androgen receptor using a non-invasive approach, RNAseq, for examining circulating tumor cells.
US20170268059 DNA HYPERMETHYLATION OF PROMOTERS OF TARGET GENES AND CLINICAL DIAGNOSIS AND TREATMENT OF HPV RELATED DISEASE  
The present invention provides arrays for gene loci that allow diagnosis of cervical cancer in patients who may be asymptomatic or have inconclusive Pap smears or cytology, and allowing earlier...
US20170267760 Checkpoint Blockade and Microsatellite Instability  
Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these...
US20170267700 Precursors for Electron Beam-Induced Deposition of Gold and Silver  
Precursors are prepared and employed in electron beam induced decomposition (EBID). The EBID precursors are complexes of the formula: X-M-Y, where M is Au or Ag; X is F, Cl, Br, I, CN, OR1, O2CR2,...
US20170266232 Activation of Marrow Infiltrating Lymphocytes in Hypoxic Alternating with Normoxic Conditions  
In some aspects, the invention relates to compositions comprising marrow infiltrating lymphocytes (“MILs”). The MILs may be activated MILs. In some aspects, the invention relates to methods for...