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US20100028355 |
HIMF AND BTK IN PULMONARY, CARDIAC AND INFLAMMATION DISORDERS
Hypoxia induced mitogenic factor (HIMF) is a member of the “found in inflammatory zone” (FIZZ)/resistin family of proteins and has potent mitogenic, angiogenic, and vasoconstrictive effects in...
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7655674 |
Modulators of hedgehog signaling pathways, compositions and uses related thereto
The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function...
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7655444 |
Method of predicting the clinical response to chemotherapeutic treatment with alkylating agents
The present invention provides methods relating to chemotherapeutic treatment of a cell proliferative disorder. In particular, a method is provided for predicting the clinical response to certain...
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US20100022639 |
Methods of Inducing Weight Loss
This invention provides a method for inducing weight loss in an animal by administering to the animal a compound which reduces the expression and/or secretion of neuropeptide Y (NPY). The effect...
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7653429 |
Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence
Techniques for detecting fluorescence emitted by molecular constituents in a wall of a body lumen include introducing an autonomous solid support into the body lumen. Cells in a lumen wall of the...
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7652043 |
WNT pathway antagonists
Aromatic compounds for treating various diseases and pathologies are disclosed. The methods use of such compounds are also provided. Accordingly, the present invention makes available methods and...
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US20100015610 |
DIAGNOSTIC SCREENING METHODS FOR DISORDERS OF THE ENDOPLASMIC RETICULUM-TO-GOLGI TRAFFICKING OF PROTEINS
The invention relates to methods of diagnosing Cranio-lenticulo-sutural dysplasia and other disorders that occur as a result of defective endoplasmic reticulum-to-Golgi trafficking using...
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7649012 |
Compounds, pharmaceutical compositions containing same, and methods of use for same
A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IV wherein R 21 =H, C 1 -C 20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CH 2 OR 25 ,...
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7648365 |
Apparatus and method for training using a human interaction simulator
A computer based training tool and method that emulates human behavior using a computer-simulated person in a realistic scenario. It provides an interactive experience in detecting deception during...
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US20100010019 |
Reactive Oxygen Generating Enzyme Inhibitor With Nitric Oxide Bioactivity and Uses Thereof
A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury,...
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US20100008920 |
Reagents and Methods for Engaging Unique Clonotypic Lymphocyte Receptors
Platforms comprising at least one lymphocyte affecting molecule and at least one molecular complex that, when bound to an antigen, engages a unique clonotypic lymphocyte receptor can be used to...
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US20100004168 |
Use of Crystallin For The Modulation of Angiogenesis
The present invention features therapeutic and prophylactic compositions and methods for modulating a blood vessel by altering angiogenesis, vasculogenesis, blood vessel stabilization, regression,...
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US20090326068 |
Therapeutics for Cancer using 3-Bromopyruvate and other Selective Inhibitors of ATP Production
The present invention relates to methods of treating a cancerous tumor using selective inhibitors of ATP production. The present invention also relates to pharmaceutical preparations comprising...
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US20090325909 |
Suppression of HIV replication and prevention and treatment of HIV
The invention provides a new and effective treatment for human immunodeficiency diseases, particularly for HIV-infected individuals. The treatment utilizes tetracycline analogs, particularly...
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7638122 |
Stat3 antagonists and their use as vaccines against cancer
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing...
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US20090317404 |
REDUCTION AND PREVENTION OF CELL-ASSOCIATED HIV TRANSEPITHELIAL MIGRATION, MICROBIDES AND OTHER FORMULATIONS AND METHODS
A vaginal microbicide including scFv-type antibodies reduces or prevents transepithelial HIV transmission. As the antibodies, anti-CD 18 and/or anti-CD 11 antibodies (of the scFv type) are used....
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US20090317333 |
PROTEIN KINASE A REPORTERS USEFUL IN HIGH THROUGHPUT ASSAYS
Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially...
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US20090311190 |
SELF-ASSEMBLED, MICROPATTERNED, AND RADIO FREQUENCY (RF) SHIELDED BIOCONTAINERS AND THEIR USES FOR REMOTE SPATIALLY CONTROLLED CHEMICAL DELIVERY
The present invention relates to a nanoscale or microscale particle for encapsulation and delivery of materials or substances, including, but not limited to, cells, drugs, tissue, gels and polymers...
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7632643 |
PCA3, PCA3 genes, and methods of use
The present invention relates, in general, to a prostate-specific antigen, PCA3. In particular, the present invention relates to nucleic acid molecules coding for the PCA3 protein; purified PCA3...
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US20090305902 |
Double-Tiled and Multi-Tiled Arrays and Methods Thereof
Described herein are multi-tiling methods that increases the number of features present on an array and methods of making and using the multi-tiled arrays. The arrays are useful, for example, for...
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US20090304596 |
Methods for Predicting Psychotropic Drugs Which Elicit Weight Gain
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that...
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US20090304588 |
BIOLOGICALLY EXCITABLE CELLS
As an alternative strategy to electronic pacemaker devices, we explored the feasibility of converting normally-quiescent ventricular myocytes into pacemakers by somatic cell fusion. The idea is to...
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7629881 |
Sensor-based adaptive wearable devices and methods
The present disclosure is directed towards apparatuses, systems and methods for providing improved sensor-based patient monitoring and tracking. In accordance with one aspect, a method is provided...
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US20090298912 |
Arginase II: A Target treatment of aging heart and heart failure
The instant invention provides methods and compositions for the treatment of cardiac dysfunction. Specifically, the invention provides methods and compositions for modulating Arginase II for the...
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7625907 |
Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
A reactive oxygen generating enzyme inhibitor with NO donor bioactivity, e.g., nitrated allopurinol, is useful to treat heart failure, stable angina, ischemic disorder, ischemic reperfusion injury,...
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US20090291923 |
TRIOXANE DIMERS HAVING HIGH ANTICANCER AND LONG-LASTING ANTIMALARIAL ACTIVITIES
The invention provides novel trioxane dimers having formulae III, IV or V: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer...
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US20090291068 |
Modulation of bio-electrical rhythms via a novel engineering approach
The present invention relates to novel compositions and methods to induce, and/or modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of...
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US20090290770 |
MRI METHODS USING DIFFUSION TENSOR IMAGING TECHNIQUES AND MRI SYSTEMS EMBODYING SAME
Featured is a method for automatically evaluating acquired MRI data, determining the quality of the acquired images and removing the image data when it is determined that an image is corrupted so...
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US20090286687 |
Method and Compositions for Detection and Enumeration of Genetic Variations
Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease...
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US20090286236 |
Method for detecting cell proliferative disorders
The present invention relates to the detection of a cell proliferative disorder associated with alterations of microsatellite DNA in a sample. The microsatellite DNA can be contained within any of...
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US20090281553 |
Devices and Methods for Treatment of Gastrointestinal Disorders
An implantation device for releasably holding implantable microstimulators can be used to guide one or more microstimulators to any site within the gastrointestinal tract for implantation. The...
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US20090274625 |
Compositions and Methods for The Treatment of Cancer
The instant invention provides methods and compositions for the treatment and diagnosis of cancer, e.g., cancers characterized by the expression of prostate specific membrane antigen (PSMA).
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7611870 |
Methods for identifying cancer risk
The present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample,...
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US20090270265 |
Molecular Characteristics of Non-Small Cell Lung Cancer
We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung...
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RE40948 |
APC antibodies
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous...
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7605003 |
Use of biomarkers for detecting ovarian cancer
The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the...
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7604989 |
Inhibition of apoptosis process and improvement of cell performance
The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is...
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US20090258848 |
BIOMARKERS FOR INFLAMMATORY BOWEL DISEASE
The present invention relates to methods of determining inflammatory bowel disease status in a subject. The invention further relates to kits for determining inflammatory bowel disease status in a...
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7601521 |
Detection of nucleic acid mutation associated with cancer by analysis of saliva
Methods for detection of a cell proliferative disorder, such as cancer, are provided utilizing analysis of target mutant nucleic acids in saliva specimens. The presence of the target mutant nucleic...
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7601489 |
Manganese ion regulation of reverse transcriptase activity and methods of modulating same
Methods of identifying agents that modulate reverse transcriptase activity in a cell by affecting manganese ion transport across a membrane of the cell are provided, as are agents identified using...
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7599729 |
Evaluating the urethra and the periurethral tissues
Systems and methods for the evaluation of the urethra and periurethral tissues may involve an MRI coil adapted for insertion into the male, female or pediatric urethra. The MRI coil may be in...
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7596409 |
Cardiac shock electrode system and corresponding implantable defibrillator system
An implantable cardioverter defibrillator (ICD) system includes an internal electrode placed in the right ventricle of the heart, and a quasi-Faraday cage (which includes a single or multiple...
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7593914 |
Method and system for the autonomous design of cybernetic systems
A system and method is provided for constructing optimal cybernetic based systems. The method is based on a process of formalized rational inquiry, measurement and planned action. More...
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7589080 |
β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases
Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a β-cyclodextrin are provided....
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US20090227692 |
Biomarkers for breast cancer
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention...
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US20090227489 |
STAT3 Agonists and Antagonists and Therapeutic Uses Thereof
The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy....
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US20090221522 |
METHODS TO CORRECT GENE SET EXPRESSION PROFILES TO DRUG SENSITIVITY
The present invention comprises a treatment approach based on gene set-expression signatures that systematically connects a sample to a profile from a reference database to extrapolate the most...
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US20090220432 |
Imaging agents and methods of using same for detecting multidrug resistance in cancer
Compounds and methods of using such compounds in the imaging and detection of multidrug resistance cancer in a subject are provided. In particular, novel imaging agents are provided which are...
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7582290 |
Packaging cell line for diphtheria toxin expressing non-replicating adenovirus
The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of...
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US20090215765 |
Neuroprotective compounds for treating optic neuropathies
Neuroprotective compounds for treating optic neuropathies and screening methods for identifying neuroprotective compounds.
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