|
Match
|
Document |
Document Title |
|
|
US20120130258 |
PROGRAMMABLE MULTIPSPECTRAL ILLIUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUES
An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a...
|
|
|
US20120129206 |
METHOD OF IDENTIFYING PATIENTS SUITABLE FOR HIGH-DOSE CYCLOPHOSPHAMIDE TREATMENT
The present invention provides methods of identifying subjects that are suitable for high-dose cyclophosphamide treatment.
|
|
|
US20120128782 |
Multicomponent Degradable Cationic Polymers
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation...
|
|
|
US20120128685 |
USE OF HIGH-DOSE OXAZAPHOSPHORINE DRUGS IN COMBINATION WITH MONOCLONAL ANTIBODIES FOR TREATING IMMUNE DISORDERS
The present invention relates to methods of treating an autoimmune disorder, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug in...
|
|
|
US20120128223 |
METHOD AND SYSTEM FOR PROCESSING ULTRASOUND DATA
A method of processing ultrasound data includes receiving ultrasound data for a first ultrasound image, the first ultrasound image being represented as a first set of discrete pixels corresponding...
|
|
|
US20120124470 |
AUDIO DISPLAY SYSTEM
An audio display system includes a pointing device configured to address locations within an interaction field, a sound system adapted to communicate with the pointing device, and—an object m...
|
|
|
US20120122834 |
SMALL MOLECULE CD4 MIMETICS AND USES THEREOF
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl,...
|
|
|
US20120122761 |
METHODS FOR DETECTING A POLYMORPHISM IN THE NFKB1 GENE PROMOTER
The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a...
|
|
|
US20120118297 |
NASALLY INSERTED AIRWAY OPENING DEVICE FOR OBSTRUCTIVE SLEEP APNEA TREATMENT
A nasally inserted airway opening device with inflatable cuff is provided to treat obstructive sleep apnea. The airway opening device includes a hollow flexible tube extending between a proximal...
|
|
|
US20120118286 |
NASAL AIRWAY MANAGEMENT DEVICE
An airway management device including a hollow flexible tube. The tube defines a lumen extending between a proximal end and a distal end. The proximal end is configured to be coupled to a...
|
|
|
8178512 |
Methods and compositions for treating diseases and disorders associated with siglec-8.
The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the...
|
|
|
US20120116685 |
Methods, System, And Medium For Associating Rheumatoid Arthritis Subjects With Cardiovascular Disease
The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as...
|
|
|
US20120115835 |
METHODS FOR TREATMENT OF BACTERIAL INFECTIONS
The peptidoglycan layer is a vital component of the bacterial cell wall, which comprises 4→3 and 3→3 transpeptide cross-linkages, the formation of which are catalyzed by D,D- and L,D...
|
|
|
US20120115804 |
COMPOSITIONS AND METHODS FOR CHARACTERIZING AND TREATING NEOPLASIA
The invention features compositions and methods for characterizing the methylation status of the Vitamin D Receptor (VDR) in neoplasia (e.g., breast carcinoma), selecting an appropriate therapy,...
|
|
|
US20120115735 |
Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene
There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a...
|
|
|
US20120114759 |
PEPTIDE/PARTICLE DELIVERY SYSTEMS
Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including...
|
|
|
US20120109202 |
INTERSEGMENTAL MOTION PRESERVATION SYSTEM FOR USE IN THE SPINE AND METHODS FOR USE THEREOF
Medical devices and kits for dynamically stabilizing or preserving motion in a spine and limiting adjacent, non-adjacent, or isolated segment degeneration of the spine while providing a controlled,...
|
|
|
US20120109201 |
INTERSEGMENTAL MOTION PRESERVATION SYSTEM FOR USE IN THE SPINE AND METHODS FOR USE THEREOF
Medical devices and kits for dynamically stabilizing or preserving motion in a spine and limiting adjacent, non-adjacent, or isolated segment degeneration of the spine while providing a controlled,...
|
|
|
US20120108654 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR OXIDATIVE STRESS AND RETINITIS PIGMENTOSA
Oxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in ocular oxidative stress related diseases including...
|
|
|
US20120108545 |
Trioxane Monomers and Dimers
Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating...
|
|
|
US20120107927 |
METHODS AND DEVICES FOR ISOLATING EMBRYONIC STEM CELLS
Methods, devices and kits are provided for isolating or enriching multicellular embryonic stem (ES) cell colonies from a mixture of multicellular ES cell colonies and single ES cells present in a...
|
|
|
US20120107184 |
DECONTAMINATION APPARATUS
A decontamination apparatus is provided including an enclosure. A first and second decontamination system may be provided within the enclosure. The first and second decontamination systems may be...
|
|
|
8168771 |
Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants
The invention provides consensus sequences for hepatitis C virus 1a and 1b. Also provided are non-synonymous changes for each residue of the consensus sequences. These sequences are useful as...
|
|
|
US20120101022 |
SELF-ASSEMBLING PEPTIDES BEARING ORGANIC ELECTRONIC FUNCTIONALITY AND APPLICATIONS EMPLOYING THE SAME
The aqueous self-assembly of oligopeptide-flanked π-conjugated molecules into discrete one-dimensional nanostructures is described. Unique to these molecules is the fact that the π-conjugated u...
|
|
|
US20120100560 |
DEVICE FOR CAPTURE, ENUMERATION, AND PROFILING OF CIRCULATING TUMOR CELLS
Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. The present invention, in one embodiment, utilizes...
|
|
|
US20120100162 |
Cyclophosphamide in Combination with Immune Therapeutics
The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an...
|
|
|
8163719 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
|
|
|
US20120095086 |
PROTEIN TYROSINE PHOSPHATASE MUTATIONS IN CANCERS
Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine...
|
|
|
US20120094295 |
NEURODEGENERATIVE DISEASE DIAGNOSTIC COMPOSITIONS AND METHODS OF USE
The invention generally provides diagnostics that employ biomarkers altered in neurodegenerative disease, as well as methods for the use of such markers in monitoring disease progression and...
|
|
|
US20120093821 |
PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS BROAD SPECTRUM HUMAN PAPILLOMAVIRUS (HPV) VACCINES
This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human papillomavirus, or HPV) L1 major capsid...
|
|
|
US20120093724 |
METHODS AND COMPOSITIONS FOR THE DETECTION OF CANCER
Various embodiments of this invention relate generally to targeted activation and delivery of therapeutic drugs to cells that produce prostate specific antigen (PSA), prostate specific membrane...
|
|
|
8160338 |
X-ray CT apparatus and myocardial perfusion image generating system
An apparatus includes a transformation table acquiring unit, a blood-flow information acquisition unit and a blood-flow image generating unit. The transformation table acquiring unit obtains a...
|
|
|
US20120088812 |
COMPOSITIONS FOR PROMOTING EPIGENETIC DNA DEMETHYLATION AND METHODS OF USE THEREFORE
The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to enhance neurogenesis, and for the...
|
|
|
8153595 |
B7-DC variants immunogenic compositions and methods of use thereof
Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector...
|
|
|
8152756 |
Active cannula for bio-sensing and surgical intervention
Disclosed is a surgical needle, or active cannula, that is capable of following a complex path through cavities and tissue within a patient's anatomy. The needle has a plurality of overlapping...
|
|
|
US20120083767 |
IMPLANTABLE BIOREACTOR FOR DELIVERY OF PARACRINE FACTORS
An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the...
|
|
|
8148577 |
Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors
Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors...
|
|
|
8148347 |
Inhibition of interaction of PSD93 and PSDS95 with nNOS and NMDA receptors
PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC....
|
|
|
8148095 |
Methods for predicting psychotropic drugs which elicit weight gain
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that...
|
|
|
8147433 |
CPR chest compression monitor and method of use
A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of...
|
|
|
US20120077763 |
METHODS FOR TREATING HEART FAILURE BY INHIBITING THE MITOCHONDRIAL SODIUM-CALCIUM EXCHANGER (mNCE)
Methods and compounds for preventing or reducing the toxic side effects of cardiac glycosides by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) are provided. Methods and compositions...
|
|
|
US20120076811 |
IMMUNODOMINANT COMPOSITIONS AND METHODS OF USE THEREFOR
The present invention relates to immunodominant compositions, including immunodominant peptides of HA1 of influenza H5 hemagglutinin, polynucleotides encoding such peptides, and their methods of...
|
|
|
US20120076752 |
Mesothelin Vaccines and Model Systems
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either...
|
|
|
US20120076681 |
PNEUMATIC STEPPER MOTOR
A stepper motor suitable for use in a medical imaging environment has (a) a cylindrical central gear having an external surface with circumferentially distributed and radially directed teeth, (b) a...
|
|
|
US20120075134 |
System and Method for Compressive Sensing
The present invention provides a system for use with an input signal and a clock signal. The system includes a physical random interval generator, a sampling analog-to-digital converter (ADC), a...
|
|
|
US20120073001 |
METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS
The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
|
|
|
US20120071890 |
METHOD AND APPARTUS FOR COCHLEAR IMPLANT SURGERY
A system for cochlear implant surgery includes a reference device having at least a portion adapted to be arranged at a fixed position relative to a cochlea of a patient to provide a reference...
|
|
|
8137962 |
Compositions for treating cystic fibrosis
The invention relates to compositions and methods of treating cystic fibrosis. More specifically, this invention relates to the use the AAV vectors and constructs to provide gene therapy to cystic...
|
|
|
8137908 |
Mesothelin vaccines and model systems
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either...
|
|
|
US20120065549 |
APPARATUS AND METHOD FOR ASSESSING VESTIBULO-OCULAR FUNCTION
A system for assessing vestibulo-ocular function includes a motion sensor system adapted to be coupled to a user's head; a data processing system configured to communicate with the motion sensor...
|