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US20090286687 |
Method and Compositions for Detection and Enumeration of Genetic Variations
Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease...
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US20090286236 |
Method for detecting cell proliferative disorders
The present invention relates to the detection of a cell proliferative disorder associated with alterations of microsatellite DNA in a sample. The microsatellite DNA can be contained within any of...
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US20090281553 |
Devices and Methods for Treatment of Gastrointestinal Disorders
An implantation device for releasably holding implantable microstimulators can be used to guide one or more microstimulators to any site within the gastrointestinal tract for implantation. The...
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US20090274625 |
Compositions and Methods for The Treatment of Cancer
The instant invention provides methods and compositions for the treatment and diagnosis of cancer, e.g., cancers characterized by the expression of prostate specific membrane antigen (PSMA).
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7611870 |
Methods for identifying cancer risk
The present invention provides methods and kits for identifying an increased risk of developing cancer in a subject. The methods include analyzing a first biological sample, such as a blood sample,...
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US20090270265 |
Molecular Characteristics of Non-Small Cell Lung Cancer
We used hierarchical clustering to examine gene expression profiles generated by serial analysis of gene expression (SAGE) in a total of nine normal lung epithelial cells and non-small cell lung...
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RE40948 |
APC antibodies
A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous...
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7605003 |
Use of biomarkers for detecting ovarian cancer
The present invention relates to a method of qualifying ovarian cancer status in a subject comprising: (a) measuring at least one biomarker in a sample from the subject and (b) correlating the...
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7604989 |
Inhibition of apoptosis process and improvement of cell performance
The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is...
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US20090258848 |
BIOMARKERS FOR INFLAMMATORY BOWEL DISEASE
The present invention relates to methods of determining inflammatory bowel disease status in a subject. The invention further relates to kits for determining inflammatory bowel disease status in a...
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7601521 |
Detection of nucleic acid mutation associated with cancer by analysis of saliva
Methods for detection of a cell proliferative disorder, such as cancer, are provided utilizing analysis of target mutant nucleic acids in saliva specimens. The presence of the target mutant nucleic...
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7601489 |
Manganese ion regulation of reverse transcriptase activity and methods of modulating same
Methods of identifying agents that modulate reverse transcriptase activity in a cell by affecting manganese ion transport across a membrane of the cell are provided, as are agents identified using...
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7599729 |
Evaluating the urethra and the periurethral tissues
Systems and methods for the evaluation of the urethra and periurethral tissues may involve an MRI coil adapted for insertion into the male, female or pediatric urethra. The MRI coil may be in...
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7596409 |
Cardiac shock electrode system and corresponding implantable defibrillator system
An implantable cardioverter defibrillator (ICD) system includes an internal electrode placed in the right ventricle of the heart, and a quasi-Faraday cage (which includes a single or multiple...
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7593914 |
Method and system for the autonomous design of cybernetic systems
A system and method is provided for constructing optimal cybernetic based systems. The method is based on a process of formalized rational inquiry, measurement and planned action. More...
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7589080 |
β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases
Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a β-cyclodextrin are provided....
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US20090227692 |
Biomarkers for breast cancer
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention...
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US20090227489 |
STAT3 Agonists and Antagonists and Therapeutic Uses Thereof
The present invention relates to methods for modulating, i.e., agonizing or antagonizing, Stat3 (Signal Transducer and Activator of Transcription3) signaling activity for use in gene therapy....
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US20090221522 |
METHODS TO CORRECT GENE SET EXPRESSION PROFILES TO DRUG SENSITIVITY
The present invention comprises a treatment approach based on gene set-expression signatures that systematically connects a sample to a profile from a reference database to extrapolate the most...
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US20090220432 |
Imaging agents and methods of using same for detecting multidrug resistance in cancer
Compounds and methods of using such compounds in the imaging and detection of multidrug resistance cancer in a subject are provided. In particular, novel imaging agents are provided which are...
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7582290 |
Packaging cell line for diphtheria toxin expressing non-replicating adenovirus
The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of...
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US20090215765 |
Neuroprotective compounds for treating optic neuropathies
Neuroprotective compounds for treating optic neuropathies and screening methods for identifying neuroprotective compounds.
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US20090215709 |
Methylation markers for diagnosis and treatment of cancers
Two hundred ten markers are provided which are epigenetically silenced in one or more cancer types. The markers can be used diagnostically, prognostically, therapeutically, and for selecting...
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US20090215171 |
PELCAM-1-related molecules compositions kit of parts and associated methods of use
An isolated polynucleotide coding for platelet endothelial cell adhesion molecule-1 (PECAM-1), and obtainable by amplifying cDNA from total human white blood cells by PCR; peptides encoding PECAM-1...
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US20090215059 |
Molecular Diagnosis of Bacteremia
A highly specific assay can be used for the detection of bacteremia in the clinical setting. The ubiquitous background endogenous DNA present in all PCR reagents is eliminated using a restriction...
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US20090209621 |
Compositions and methods for decreasing microrna expression for the treatment of neoplasia
The invention generally features compositions and methods that are useful for treating or diagnosing a neoplasia. The invention is based in part on the observation that c-Myc activated expression...
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US20090208934 |
PECAM-1 GENOTYPE
The invention relates to methods of identifying inter-patient differences in genotype of PECAM- 1 to diagnose and assess risk of arterial disease. It further relates to methods of identifying...
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US20090208505 |
Mutations of the pik3ca gene in human cancers
Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the...
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7576323 |
Point-of-care mass spectrometer system
A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a...
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US20090202439 |
Methods for treatment of angiogenesis
The present invention includes methods for treatment and prophylaxis of diseases, post-surgical disorders and bacterial infections associated with lactosylceramide. The methods generally provide...
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7572906 |
Viral vectors and host cells and methods of making and using them
The present invention provides a conditionally replicating viral vector, methods of making, modifying, propagating and selectively packaging, and using such a vector, isolated molecules of...
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7572599 |
Metalloprotease activation of myostatin, and methods of modulating myostatin activity
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents...
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US20090196877 |
Novel Method to Increase Memory T Lymphocytes and Enhance Their Functions
The invention generally features compositions and methods that are useful for increasing immune function. Such methods can be employed to enhance innate immunity for the prevention or treatment of...
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7570426 |
Apparatus and system for wide angle narrow-band optical detection in daylight
Techniques for filtering light include, along a central optical axis, an entrance window; a first polarizer, a narrowband polarization-changing material, a second polarizer, and an exit window. The...
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7570202 |
Polarimetric selectivity method for suppressing cross-track clutter in sounding radars
Methods for suppressing cross-track clutter in a sounding radar utilize polarimetric selectivity in two ways: (1) transmitting full-beam circular polarization and separating the desired signal of...
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US20090192437 |
WEARABLE PHOTOACTIVATOR FOR OCULAR THERAPEUTIC APPLICATIONS AND USES THEREOF
The invention provides a wearable device for delivery of light of a desired wavelength and power to the cornea of a subject. The device includes a frame for attachment of a light source housing...
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US20090191570 |
Inhibition of Interaction of PSD93 and PSD95 with nNOS and NMDA Receptors
PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC....
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7566768 |
Promyostatin peptides and methods of using same
The present invention provides substantially purified peptide portions of a promyostatin polypeptide. For example, the invention provides proteolytic fragments of a promyostatin polypeptide such as...
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US20090186339 |
Human transcriptomes
Global gene expression patterns have been characterized in normal and cancerous human cells using serial analysis of gene expression (SAGE). Cancer cell-specific, cell-type specific, and...
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US20090186016 |
AUGMENTATION OF ENDOTHELIAL THROMBORESISTANCE
Stretch-induced increased hemodynamic load adversely affects endothelial cell function and is an important contributor to thromboembolus formation in heart failure, valvular heart disease, atrial...
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US20090182019 |
Histone deacetylase inhibitors
The present invention provides novel HDAC inhibitors and methods of treating diseases using the same.
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US20090181010 |
Arginase II: a target for the prevention of atherosclerosis
The instant invention provides methods and compositions for the treatment of. atherosclerotic disease. Specifically, the invention provides methods and compositions for modulating the activity of...
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7561802 |
Mobile communications via an optical signal during adverse atmospheric conditions
A communications system for wireless transceiving of information, comprising at least one multiple optical beam scanning array transceiver located in a satellite for wirelessly transceiving the...
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7560540 |
Nucleic acid encoding dendritic cell co-stimulatory molecules
A novel costimulatory protein molecule, B7-DC, which is a member of the B7 family, is described as is DNA coding therefor and expression vectors comprising this DNA. B7-DC protein, fragments,...
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7560482 |
Inhibitors of plasmepsins
Compounds and methods for the inhibition of anti-malarial target aspartyl protease plasmepsins (e.g. Plasmepsin I, Plasmepsin II, Plasmepsin IV and HAP) are provided. The compounds are based on...
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US20090175798 |
Mycobacterial Catalase-Peroxidase in the Diagnosis and Treatment of Sarcoidosis
Provided are diagnostic and therapeutic methods of treating sarcoidosis comprising the use of microbial catalase-peroxidase protein, its peptide fragments, or derivatives thereof.
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US20090175790 |
CARDIAC ARRHYTHMIA TREATMENT METHODS AND BIOLOGICAL PACEMAKER
Disclosed are methods of preventing or treating cardiac arrhythmia. In one embodiment, the methods include administering to an amount of at least one polynucleotide that modulates an electrical...
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7557200 |
Superior molecular vaccine based on self-replicating RNA, suicidal DNA or naked DNA vector, that links antigen with polypeptide that promotes antigen presentation
Improved molecular vaccines comprise nucleic acid vectors that encode a fusion polypeptide that includes polypeptide or peptide physically linked to an antigen. The linked polypeptide is one that...
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7557144 |
Modulation of protein expression using carbocyclic aryl alkenoic acid derivatives
The present invention generally relates to diseases or conditions modulated by undesired protein expression. In one aspect, the methods provide for administration to a mammal, particularly a human,...
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7556855 |
Impact resistant flexible body device
An impact resistant device is provided comprising a support matrix and a plurality of energy absorbing elements operatively connected to the support matrix, each element comprising at least one...
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