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US20120029071 |
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING RADIATION INJURY
The invention provides compositions and methods featuring Nrf2 activators for treating or preventing radiation-associated tissue damage.
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US20120029005 |
SPIPERONE DERIVATIVES AND METHODS OF TREATING DISORDERS
Described herein are spiperone derivative compounds which have been found to be useful in methods of stimulating CaCC and treating disorders (or symptoms thereof) associated with CaCC including...
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US20120028921 |
METHODS AND COMPOSITIONS USING OXIDIZED PHOSPHOLIPIDS
The instant invention provides compositions, e.g., compositions comprising oxidized phospholipids, for the treatment of diseases, disorders and conditions, e.g., cute lung injury syndromes, sepsis,...
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US20120027799 |
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING INFLAMMATORY BOWEL DISEASE AND COLON CANCER
The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in...
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RE43152 |
Method and apparatus for segmenting small structures in images
A method for segmenting a small feature in a multidimensional digital array of intensity values in a data processor computes an edge metric along each ray of a plurality of multidimensional rays...
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US20120022232 |
CELLS FOR INCREASED PROTEIN EXPRESSION COMPRISING ONE OR MORE RELEASE FACTORS AND METHODS OF USE
The invention provides recombinant cells or recombinant restrictive cells for overexpressing one or more proteins comprising one or more release factors. The invention also provides methods for...
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US20120012530 |
MOLECULARLY IMPRINTED POLYMER ION EXCHANGE RESINS
A molecularly imprinted polymer ion exchange resin for selectively removing one or more inorganic ions in a liquid medium is disclosed and described. The exchange resin can include a bead having a...
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8099151 |
System and method for magnetic-resonance-guided electrophysiologic and ablation procedures
A system and method for using magnetic resonance imaging to increase the accuracy of electrophysiologic procedures includes an invasive combined electrophysiology and imaging antenna catheter which...
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8097632 |
Inhibitors of hedgehog signaling pathways, compositions and uses related thereto
The present invention makes available assays and reagents inhibiting paracrine and/or autocrine signals produced by a hedgehog protein or aberrant activation of a hedgehog signal transduction...
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8096972 |
Devices for intraocular drug delivery
A therapeutic agent delivery device that is particularly suitable for delivery of a therapeutic agent to limited access regions, such as the posterior chamber of the eye and inner ear. Preferred...
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US20120010102 |
MODULATION OF ABCG2-MEDIATED URATE TRANSPORT TO TREAT HYPERURICEMIA AND GOUT
Genome-wide association studies (GWAS) was recently used to identify SNPs in a genomic region on chromosome 4 that associate with serum urate levels and gout. The present disclosure shows that...
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US20120009573 |
Antisense Transcriptomes of Cells
Transcription in mammalian cells can be assessed at a genome-wide level, but it has been difficult to reliably determine whether individual transcripts are derived from the Plus- or Minus-strands...
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US20120009174 |
BIOMARKERS FOR MYOCARDIAL ISCHEMIA
This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial...
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US20120009121 |
PSMA-TARGETING COMPOUNDS AND USES THEREOF
Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
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8094810 |
Unidirectional proxy re-encryption
A method for performing unidirectional proxy re-encryption includes generating a first key pair comprising a public key (pk) and a secret key (sk) and generating a re-encryption key that changes...
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8094081 |
Dual band radio frequency (RF) and optical communications antenna and terminal design methodology and implementation
A dual-band antenna is provided that combines two normally disparate communications modes into a single compact aperture minimizing overall mass and volume, while maintaining high performance...
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8093261 |
Rapid release mini-tablets provide analgesia in laboratory animals
Pellets containing an analgesic uniformly dispersed in a lipid carrier such as cholesterol mixed with fatty acid esters, can be used to provide long term pain relief. 5 mg...
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8093013 |
Claudins as markers for early detection, diagnosis, prognosis and as targets of therapy for breast and metastatic brain or bone cancer
Methods of diagnosis, prognosis, and treatment of breast cancer, and of metastatic brain cancer, are provided The diagnostic and prognostic methods involve the immunohistochemical detection of the...
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8091429 |
Apparatus and method for high frequency low pressure arc flash sensor
A pressure sensor for detecting an electric arc in an electrical switchboard, the sensor being in an enclosed case containing a conical opening, the case being placed in the switchboard. A pressure...
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US20120004289 |
ANNEXIN A11 AND ASSOCIATED GENES AS BIOMARKERS FOR CANCER
The instant invention provides methods and compositions for the diagnosis and treatment of cancer. The invention also provides method and compositions for determining if a subject is, or is at risk...
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US20120003156 |
METHODS FOR TREATING NEOPLASIA BY INHIBITING LACTATE DEHYDROGENASE AND/OR NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE
The invention provides compositions for the diagnosis or treatment of neoplasias, including lymphomas, leukemias, brain cancers (e. glioblastomas, medulloblastomas), breast cancer, colon cancer,...
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8088621 |
Adenoviral fiber exchange shuttle system
The instant invention provides methods and compositions for generating recombinant adenoviral vectors. The invention also provides kits comprising for the generation of recombinant adenoviral vectors.
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8088074 |
Cerebral vascular reactivity monitoring
A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate...
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US20110319939 |
COMPRESSION-DISTRACTION SPINAL FIXATION SYSTEM AND KIT
Compression-distraction spinal fixation systems, and methods of performing compression-distraction spinal fixation, are provided that include screw-rod constructs having a ratcheting mechanism....
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US20110319499 |
Methods for the Detection of Advanced Glycation Endproducts and Markers for Disease
The present invention provides compositions and methods for detecting carboxymethyl-lysine (CML) and circulating receptor for advanced glycation end (RAGE) products, and methods for correlating CML...
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US20110319477 |
MUTATIONS OF THE PIK3CA GENE IN HUMAN CANCERS
Phosphatidylinositol 3-kinases (PI3Ks) are known to be important regulators of signaling pathways. To determine whether PI3Ks are genetically altered in cancers, we analyzed the sequences of the...
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US20110317810 |
METHODS AND SYSTEMS FOR LOCATING OBJECTS EMBEDDED IN A BODY
A method of processing image data from an imaging system for locating a plurality N of objects embedded in a body includes receiving data for a first two-dimensional image of a region of interest...
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US20110315656 |
FERROMAGNETIC NANORINGS, MEDIUMS EMBODYING SAME INCLUDING DEVICES AND METHODS RELATED THERETO
Featured is a magnetic ring structure including at least a vortex magnetic state such as symmetrically and asymmetrically shaped nanorings, having small diameters (e.g., on the order of 100 nm). In...
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US20110313233 |
DOWN-REGULATION OF COLD SHOCK PROTEINS FOR CANCER TREATMENT
The present invention is in the field of treatment of diseased tissues, including cancerous tissues. In one embodiment, the present invention provides methods of identifying tissues that...
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US20110311791 |
SYSTEM AND METHOD FOR PRECISION TRANSPORT, POSITIONING, AND ASSEMBLING OF LONGITUDINAL NANO-STRUCTURES
A method for assembling multi-component nano-structures that includes dispersing a plurality of nano-structures in a fluid medium, and applying an electric field having an alternating current (AC)...
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US20110311506 |
PIGGYBAC TRANSPOSON VARIANTS AND METHODS OF USE
The present invention provides hyperactive piggyBac transposons, in particular hyperactive piggyBac transposons from Trichoplusia ni (cabbage looper moth) that transpose at a higher frequency than...
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US20110311500 |
COMBINATION BACTERIOLYTIC THERAPY FOR THE TREATMENT OF TUMORS
Current approaches for treating cancer are limited, in part, by the inability of drugs to affect the poorly vascularized regions of tumors. We have found that spores of anaerobic bacteria in...
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8081991 |
Wireless based positioning method and apparatus
A system and method is described herein to determine the physical location of a user within an edifice. At least three wireless access points, for example, 802.11 nodes, receives and transmits...
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8080533 |
Hypoxia induced mitogenic factor
We found that FIZZ1/RELMα is inducible by hypoxia in lung. The hypoxia-upregulated expression of FIZZ1/RELMα was located in the pulmonary vasculature, bronchial epithelial cells, and type II...
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8080367 |
Regulation of cell survival by HSP90 and IP6K2
Anti-cancer drugs are identified by screening for agents and compounds which inhibit the binding of HSP90 and IP6K2. In vitro and in vivo assays can be used. Any phenomenon associated with the...
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8080235 |
Protein kinase A reporters useful in high throughput assays
Protein kinase A reporters useful for obtaining measurements of protein kinase A activity with high spatial and temporal resolution can be used in high throughput assays to identify potentially...
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US20110306614 |
N-Hydroxylsulfonamide Derivatives as New Physiologically Useful Nitroxyl Donors
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
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US20110305772 |
COMPOSITIONS AND METHODS FOR EX VIVO HEPATIC NUCLEIC ACID DELIVERY
The invention provides compositions and methods for delivery of nucleic acids to the liver ex vivo. The method includes slow, low pressure infusion of the nucleic acid into the liver to efficiently...
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US20110305768 |
QUICK-DISSOLVING ORAL THIN FILM FOR TARGETED DELIVERY OF THERAPEUTIC AGENTS
This invention describes a quick-dissolving thin film strips comprising bioactive components encapsulated within pH-sensitive polymeric microparticles. The microparticles are embedded within the...
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US20110305689 |
TREATMENT OF CHRONIC INFLAMMATORY RESPIRATORY DISORDERS
This invention relates, e.g., to a method for treating a subject having a chronic inflammatory respiratory disorder, comprising administering to the subject an effective amount of an inhibitor of...
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8078262 |
Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies
The present invention relates to methods of passive infrared imaging and dynamic infrared imaging of a tumor or lesion (“DIR”) where multiple images are taken before, during and after heating...
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8076073 |
Cholesterol and hedgehog signaling
The present invention sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol...
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US20110301646 |
COMPRESSION-DISTRACTION SPINAL FIXATION SYSTEM
Compression-distraction spinal fixation systems, and methods of performing compression-distraction spinal fixation, are provided that include screw-rod constructs having a ratcheting mechanism....
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US20110301226 |
COMPOSITIONS AND METHODS FOR TREATING HEPATIC NEOPLASIA
The present invention provides compositions and methods featuring miR-26 microRNA polynucleotides for the diagnosis, treatment or prevention of hepatic neoplasia.
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US20110301163 |
QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS
Described herein are methods of inhibiting methionine aminopeptidase or SirT1, inhibiting angiogenesis, and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, SirT1...
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US20110300168 |
COMPOSITIONS AND METHODS FOR INDUCING AN IMMUNE RESPONSE AGAINST INFLUENZA ANTIGENS
This disclosure provides compositions and methods for inducing an immune response against influenza antigens, for example in elderly populations, as well as a sensitive artificial antigen...
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8071733 |
Antibodies that specifically bind hedgehog-derived polypeptides
The present invention provides two novel polypeptides, referred to as the “N” and “C” fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after...
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8071304 |
Methods for detecting a polymorphism in the NFKB1 gene promoter
The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a...
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8071290 |
Hypermethylation of GATA-4 and GATA-5 transcription factor genes in cancer
Methods are provided for identifying the presence of cancer cells in a sample by detecting hypermethylation of the promoter region of a GATA-4 transcription factor gene, a GATA-5 transcription...
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US20110293608 |
ANNEXIN A2 AS IMMUNOLOGICAL TARGET
AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients...
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