Patents and Patent Applications from Johns Hopkins University


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US20120130258 PROGRAMMABLE MULTIPSPECTRAL ILLIUMINATION SYSTEM FOR SURGERY AND VISUALIZATION OF LIGHT-SENSITIVE TISSUES  
An observation system for viewing light-sensitive tissue includes an illumination system configured to illuminate the light-sensitive tissue, an imaging system configured to image at least a...
US20120129206 METHOD OF IDENTIFYING PATIENTS SUITABLE FOR HIGH-DOSE CYCLOPHOSPHAMIDE TREATMENT  
The present invention provides methods of identifying subjects that are suitable for high-dose cyclophosphamide treatment.
US20120128782 Multicomponent Degradable Cationic Polymers  
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation...
US20120128685 USE OF HIGH-DOSE OXAZAPHOSPHORINE DRUGS IN COMBINATION WITH MONOCLONAL ANTIBODIES FOR TREATING IMMUNE DISORDERS  
The present invention relates to methods of treating an autoimmune disorder, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an oxazaphosphorine drug in...
US20120128223 METHOD AND SYSTEM FOR PROCESSING ULTRASOUND DATA  
A method of processing ultrasound data includes receiving ultrasound data for a first ultrasound image, the first ultrasound image being represented as a first set of discrete pixels corresponding...
US20120124470 AUDIO DISPLAY SYSTEM  
An audio display system includes a pointing device configured to address locations within an interaction field, a sound system adapted to communicate with the pointing device, and—an object m...
US20120122834 SMALL MOLECULE CD4 MIMETICS AND USES THEREOF  
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl,...
US20120122761 METHODS FOR DETECTING A POLYMORPHISM IN THE NFKB1 GENE PROMOTER  
The present invention discloses a functional relationship between a recognized disease condition and a polymorphism in the nucleotide factor kappa B promoter (NFKB1). This relationship provides a...
US20120118297 NASALLY INSERTED AIRWAY OPENING DEVICE FOR OBSTRUCTIVE SLEEP APNEA TREATMENT  
A nasally inserted airway opening device with inflatable cuff is provided to treat obstructive sleep apnea. The airway opening device includes a hollow flexible tube extending between a proximal...
US20120118286 NASAL AIRWAY MANAGEMENT DEVICE  
An airway management device including a hollow flexible tube. The tube defines a lumen extending between a proximal end and a distal end. The proximal end is configured to be coupled to a...
8178512 Methods and compositions for treating diseases and disorders associated with siglec-8.  
The invention provides therapeutic methods and compositions for the prevention and treatment of Siglec-8 associated diseases and disorders such as asthma and allergic reactions. In particular, the...
US20120116685 Methods, System, And Medium For Associating Rheumatoid Arthritis Subjects With Cardiovascular Disease  
The present invention relates to a system and a medium for analyzing one or more analytes in rheumatoid arthritis subjects to determine whether the subject is at increased risk of diseases such as...
US20120115835 METHODS FOR TREATMENT OF BACTERIAL INFECTIONS  
The peptidoglycan layer is a vital component of the bacterial cell wall, which comprises 4→3 and 3→3 transpeptide cross-linkages, the formation of which are catalyzed by D,D- and L,D...
US20120115804 COMPOSITIONS AND METHODS FOR CHARACTERIZING AND TREATING NEOPLASIA  
The invention features compositions and methods for characterizing the methylation status of the Vitamin D Receptor (VDR) in neoplasia (e.g., breast carcinoma), selecting an appropriate therapy,...
US20120115735 Pathways Underlying Pancreatic Tumorigenesis and an Hereditary Pancreatic Cancer Gene  
There are currently few therapeutic options for patients with pancreatic cancers and new insights into the pathogenesis of this lethal disease are urgently needed. To this end, we performed a...
US20120114759 PEPTIDE/PARTICLE DELIVERY SYSTEMS  
Polymeric nanoparticles, microparticles, and gels for delivering cargo, e.g., a therapeutic agent, such as a peptide, to a target, e.g., a cell, and their use for treating diseases, including...
US20120109202 INTERSEGMENTAL MOTION PRESERVATION SYSTEM FOR USE IN THE SPINE AND METHODS FOR USE THEREOF  
Medical devices and kits for dynamically stabilizing or preserving motion in a spine and limiting adjacent, non-adjacent, or isolated segment degeneration of the spine while providing a controlled,...
US20120109201 INTERSEGMENTAL MOTION PRESERVATION SYSTEM FOR USE IN THE SPINE AND METHODS FOR USE THEREOF  
Medical devices and kits for dynamically stabilizing or preserving motion in a spine and limiting adjacent, non-adjacent, or isolated segment degeneration of the spine while providing a controlled,...
US20120108654 COMPOSITIONS AND METHODS FOR THE TREATMENT OF OCULAR OXIDATIVE STRESS AND RETINITIS PIGMENTOSA  
Oxidative damage contributes to cone cell death in retinitis pigmentosa and death of rods, cones, and retinal pigmented epithelial (RPE) cells in ocular oxidative stress related diseases including...
US20120108545 Trioxane Monomers and Dimers  
Monomeric and dimeric trioxane fluoroaryl amides, 5-carbon-linked, C-10 non-acetal trioxane dimer esters; trioxane silylamides; and trioxane dimer orthoesters and methods of their use for treating...
US20120107927 METHODS AND DEVICES FOR ISOLATING EMBRYONIC STEM CELLS  
Methods, devices and kits are provided for isolating or enriching multicellular embryonic stem (ES) cell colonies from a mixture of multicellular ES cell colonies and single ES cells present in a...
US20120107184 DECONTAMINATION APPARATUS  
A decontamination apparatus is provided including an enclosure. A first and second decontamination system may be provided within the enclosure. The first and second decontamination systems may be...
8168771 Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants  
The invention provides consensus sequences for hepatitis C virus 1a and 1b. Also provided are non-synonymous changes for each residue of the consensus sequences. These sequences are useful as...
US20120101022 SELF-ASSEMBLING PEPTIDES BEARING ORGANIC ELECTRONIC FUNCTIONALITY AND APPLICATIONS EMPLOYING THE SAME  
The aqueous self-assembly of oligopeptide-flanked π-conjugated molecules into discrete one-dimensional nanostructures is described. Unique to these molecules is the fact that the π-conjugated u...
US20120100560 DEVICE FOR CAPTURE, ENUMERATION, AND PROFILING OF CIRCULATING TUMOR CELLS  
Applications in nanomedicine, such as diagnostics and targeted therapeutics, rely on the detection and targeting of membrane biomarkers. The present invention, in one embodiment, utilizes...
US20120100162 Cyclophosphamide in Combination with Immune Therapeutics  
The present invention relates to methods of treating a cancer and in particular, a B-cell derived cancer, using a lymphocytotoxic but hematopoeitic cell sparing high-dose pulsed amount of an...
8163719 Regulators of the hedgehog pathway, compositions and uses related thereto  
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
US20120095086 PROTEIN TYROSINE PHOSPHATASE MUTATIONS IN CANCERS  
Tyrosine phosphorylation, regulated by protein tyrosine phosphatases (PTPs) and kinases (PTKs), is important in signaling pathways underlying tumorigenesis. A mutational analysis of the tyrosine...
US20120094295 NEURODEGENERATIVE DISEASE DIAGNOSTIC COMPOSITIONS AND METHODS OF USE  
The invention generally provides diagnostics that employ biomarkers altered in neurodegenerative disease, as well as methods for the use of such markers in monitoring disease progression and...
US20120093821 PAPILLOMAVIRUS-LIKE PARTICLES (VLP) AS BROAD SPECTRUM HUMAN PAPILLOMAVIRUS (HPV) VACCINES  
This invention relates, e.g., to a virus-like particle (VLP) composition assembled from a chimeric polypeptide comprising a papilloma virus (e.g., human papillomavirus, or HPV) L1 major capsid...
US20120093724 METHODS AND COMPOSITIONS FOR THE DETECTION OF CANCER  
Various embodiments of this invention relate generally to targeted activation and delivery of therapeutic drugs to cells that produce prostate specific antigen (PSA), prostate specific membrane...
8160338 X-ray CT apparatus and myocardial perfusion image generating system  
An apparatus includes a transformation table acquiring unit, a blood-flow information acquisition unit and a blood-flow image generating unit. The transformation table acquiring unit obtains a...
US20120088812 COMPOSITIONS FOR PROMOTING EPIGENETIC DNA DEMETHYLATION AND METHODS OF USE THEREFORE  
The invention features compositions and methods for modulating the expression of Gadd45 and the use of such compositions and methods as neuroprotectants, to enhance neurogenesis, and for the...
8153595 B7-DC variants immunogenic compositions and methods of use thereof  
Compositions and methods for costimulating T cells (i.e., increasing antigen-specific proliferation of T cells, enhancing cytokine production by T cells, stimulating differentiation ad effector...
8152756 Active cannula for bio-sensing and surgical intervention  
Disclosed is a surgical needle, or active cannula, that is capable of following a complex path through cavities and tissue within a patient's anatomy. The needle has a plurality of overlapping...
US20120083767 IMPLANTABLE BIOREACTOR FOR DELIVERY OF PARACRINE FACTORS  
An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the...
8148577 Polyamines useful as anti-parasitic and anti-cancer therapeutics and as lysine-specific demethylase inhibitors  
Polyamine, polyamine/guanidino, and polyamine/biguanide compounds are disclosed. The compounds are useful as anti-cancer and anti-parasitic treatments. The compounds are also useful as inhibitors...
8148347 Inhibition of interaction of PSD93 and PSDS95 with nNOS and NMDA receptors  
PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC....
8148095 Methods for predicting psychotropic drugs which elicit weight gain  
The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that...
8147433 CPR chest compression monitor and method of use  
A chest compressions monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of...
US20120077763 METHODS FOR TREATING HEART FAILURE BY INHIBITING THE MITOCHONDRIAL SODIUM-CALCIUM EXCHANGER (mNCE)  
Methods and compounds for preventing or reducing the toxic side effects of cardiac glycosides by inhibiting the mitochondrial sodium-calcium exchanger (mNCE) are provided. Methods and compositions...
US20120076811 IMMUNODOMINANT COMPOSITIONS AND METHODS OF USE THEREFOR  
The present invention relates to immunodominant compositions, including immunodominant peptides of HA1 of influenza H5 hemagglutinin, polynucleotides encoding such peptides, and their methods of...
US20120076752 Mesothelin Vaccines and Model Systems  
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either...
US20120076681 PNEUMATIC STEPPER MOTOR  
A stepper motor suitable for use in a medical imaging environment has (a) a cylindrical central gear having an external surface with circumferentially distributed and radially directed teeth, (b) a...
US20120075134 System and Method for Compressive Sensing  
The present invention provides a system for use with an input signal and a clock signal. The system includes a physical random interval generator, a sampling analog-to-digital converter (ADC), a...
US20120073001 METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PRURITIS  
The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
US20120071890 METHOD AND APPARTUS FOR COCHLEAR IMPLANT SURGERY  
A system for cochlear implant surgery includes a reference device having at least a portion adapted to be arranged at a fixed position relative to a cochlea of a patient to provide a reference...
8137962 Compositions for treating cystic fibrosis  
The invention relates to compositions and methods of treating cystic fibrosis. More specifically, this invention relates to the use the AAV vectors and constructs to provide gene therapy to cystic...
8137908 Mesothelin vaccines and model systems  
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either...
US20120065549 APPARATUS AND METHOD FOR ASSESSING VESTIBULO-OCULAR FUNCTION  
A system for assessing vestibulo-ocular function includes a motion sensor system adapted to be coupled to a user's head; a data processing system configured to communicate with the motion sensor...