Patents and Patent Applications from Johns Hopkins University


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US20180171413 HEAD AND NECK SQUAMOUS CELL CARCINOMA ASSAYS  
We queried DNA from saliva or plasma of 93 HNSCC patients, searching for somatic mutations or human papillomavirus genes, collectively referred to as tumor DNA. When both plasma and saliva were...
US20180171306 METHODS FOR INCREASING THE INFECTIVITY OF VIRUSES  
Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the...
US20180171291 DERIVATION OF ENDOTHELIAL CELLS FROM MAMMALIAN PLUIRPOTENT STEM CELLS  
This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (PSCs) into endothelial cells (ECs) in vitro, by plating a single-cell suspension of...
US20180171276 DEVICE AND METHOD FOR ANALYSIS OF TISSUE CONSTRUCTS  
The present invention provides an integrated microphysiological device and fabrication methods thereof, as well as methods of use to perform biological assays.
US20180169276 Contrast Agent and Associated Methods  
Example substances and methods relating to contrast agents are provided. An example method includes combining a surface active protein, a stabilizer, and a dispersion media to form a solution. The...
US20180169263 LIPID-BASED DRUG CARRIERS FOR RAPID PENETRATION THROUGH MUCUS LININGS  
Mucus-penetrating liposomal nanoparticles and methods of making and using thereof are described herein. The nanoparticles contain one or more lipids, one or more PEG-conjugated lipids, and...
US20180169221 Methods for Enhancing Antigen-Specific Immune Responses  
Described herein are methods comprising administering to a mammalian subject an effective amount of an annexin chimeric fusion protein, wherein the annexin chimeric fusion protein comprises at...
US20180169108 Drug Combinations For the Treatment of HIV  
Provided herein are effective latency-reversing agent (LRA) combinations of drugs for the reversal of HIV-1 latency. Such methods utilize, for example, the combination of a protein kinase C...
10002104 Dual autonomous telemetry data acquisition system and real time opto-isolated receivers for use therewith  
A serial digital data acquisition receiver (SDDAR) or system of receivers may include an opto-isolator assembly, sampling logic and a USB interface. Both a CLK signal and a DATA signal may each...
US20180161315 TREATMENT METHODS UTILIZING STEM CELL MOBILIZERS AND IMMUNOSUPPRESSIVE AGENTS  
The present invention relates to the field of organ transplantation. In one aspect, the present invention provides methods of treating an organ transplant recipient comprising administering to the...
US20180161277 SUSTAINED DELIVERY OF THERAPEUTIC AGENTS TO AN EYE COMPARTMENT  
Compositions and methods for treating eye disorders by administering a drug delivery system into an eye compartment of the patient, wherein the drug delivery system contains a particle containing...
US20180161274 Liposome Compositions Encapsulating Modified Cyclodextrin Complexes and Uses Thereof  
The invention provides liposome compositions comprising liposomes encapsulating cyclodextrins that both bear ionizable functional groups, such as on their solvent-exposed surfaces, and encompass...
US20180161100 PERSONALIZED COMPUTATIONAL MODELING OF ATRIAL FIBROSIS TO GUIDE CATHETER ABLATION OF ATRIAL FIBRILLATION  
Methods, system, and media for identifying one or more ablation locations in an atrial tissue region in an atrial fibrillation (AF) patient with atrial fibrosis are disclosed. Three-dimensional...
US20180160917 A DEVICE AND METHOD FOR NON-INVASIVE LEFT VENTRICULAR END DIASTOLIC PRESSURE (LVEDP) MEASUREMENT  
The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP)...
US20180160829 SPILL-PROOF CUP  
An embodiment in accordance with the present invention is directed to a spill-proof cup. The cup includes an innovative mechanisms to allow for a completely spill-proof and ergonomic cup. The cup...
9997788 Methods of producing porous platinum-based catalysts for oxygen reduction  
A porous metal that comprises platinum and has a specific surface area that is greater than 5 m2/g and less than 75 m2/g. A fuel cell includes a first electrode, a second electrode spaced apart...
9994865 PEG-Prom mediated surface expression of avidin/streptavidin  
The presently disclosed subject matter relates to compositions and methods directed to cancer theranostic nucleic acid constructs that permit simultaneous cancer-specific viral replication,...
9994825 Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix  
Described are methods for differentiating mammalian pluripotent stem cells towards a population of cells that can self-organize into vascular networks in vitro when harvested cells of the present...
9993631 Ventriculoperitoneal shunt with pressure responsive element  
A ventriculoperitoneal shunt includes a proximal catheter, a distal catheter, a shunt valve operably coupling the proximal catheter to the distal catheter, and a contrast container containing...
9993546 Lysosomal targeting of antigens employing nucleic acids encoding lysosomal membrane polypeptide/antigen chimeras  
The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen...
9993472 Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2  
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases...
US20180156797 OPTIMIZING DIAGNOSTICS FOR GALACTOFURANOSE CONTAINING ANTIGENS  
Disclosed herein are methods of detecting microbial infection in mammalian subjects comprising treatment of a sample and detection of galactofuranose (galF)-containing antigenic components...
US20180155770 Genomic Alterations in the Tumor and Circulation of Pancreatic Cancer Patients  
Pancreatic adenocarcinoma has the worst overall mortality of any solid tumor, with only 7% of patients surviving after 5 years. To evaluate the clinical implications of genomic alterations in this...
US20180153737 METHOD AND DEVICE FOR NON-INVASIVE ANATOMICAL AND SYSTEMIC COOLING AND NEUROPROTECTION  
The present invention provides a method and device for non-invasive anatomical and systemic cooling, fluid removal and/or energy removal. The method and device provide for removal of fluid and...
9988407 Prodrugs of prostate specific membrane antigen (PSMA) inhibitor  
Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.
9987370 Self-assembling drug amphiphiles and methods for synthesis and use  
The present invention provides herein the design of monodisperse, amphiphilic anticancer drugs—which are now termed “drug amphiphiles” (DAs)—that can spontaneously associate into discrete, stable...
US20180148783 METHOD OF EPIGENETIC ANALYSIS FOR DETERMINING CLINICAL GENETIC RISK  
The present invention provides a method for identifying a subject having or at risk of having a metabolic disease, such as diabetes or obesity. The invention is based on an approach to identify...
US20180148480 SYNTHETIC ENHANCEMENT OF THE T-CELL ARMAMENTARIUM AS AN ANTI-CANCER THERAPY  
The present invention relates to the field of cancer. More specifically, the present invention provides compositions and methods for using synthetically enhanced T-cells to treat cancer. The...
US20180148468 USE OF UAP INHIBITORS TO INHIBIT FLUX THROUGH THE HEXOSAMINE BIOSYNTHETIC PATHWAY  
Disclosed are UAP inhibitors to inhibit glucose flux in the hexosamine biosynthetic pathway and methods of treating a disease using the inhibitors.
US20180147207 COMPOSITIONS AND METHODS FOR THERAPY OF PROSTATE CANCER USING DRUG COMBINATIONS TO TARGET POLYAMINE BIOSYNTHESIS AND RELATED PATHWAYS  
Provided are compositions and methods for treating prostate conditions. The methods involve administering to an individual in need thereof a composition that contains i) an inhibitor of methionine...
US20180146703 NOVEL FLUORIDE PRENATAL DIETARY SUPPLEMENT  
The presently disclosed subject matter provides compositions, kits, and methods for administering a prenatal dietary supplement comprising at least about 3 mg of bioavailable fluoride to a...
9982306 Somatic mutations in ATRX in brain cancer  
We determined the sequence of ATRX and DAXX in 447 cancers from various sites. We found mutations most commonly in pediatric glioblastoma multiformae (GBM) (11.1%), adult GBM (6.5%),...
9982304 ARID1A and PPP2R1A mutations in cancer  
Two genes, ARID1A (AT-rich interactive domain-containing protein 1A) and PPP2R1A (protein-phosphatase 2, regulatory subunit 1, alpha), can be used in methods which are useful for detecting cancer,...
US20180145506 Intelligent Power Routing Device  
A power routing device includes processing circuitry configured to receive inputs from device monitors configured to determine load status information from a plurality of loads, power-source...
US20180141983 Anti-Cancer DNA Vaccine Employing Plasmids Encoding Signal Sequence, Mutant Oncoprotein Antigen, and Heat Shock Protein  
Novel nucleic acid vectors comprising sequences encoding (a) an antigen, (b) a signal peptide, and (c) a heat shock protein, are disclosed, as are methods for using such vectors to induce...
US20180141120 EMPOWERING ADDITIVE MANUFACTURING METALS AND ALLOYS AGAINST LOCALIZED THREE-DIMENSIONAL CORROSION  
Functionalized metallic feedstock and three-dimensional articles formed therefrom via an additive manufacturing process are provided. The functionalized metallic feedstock includes a plurality of...
US20180140702 SHAPE MEMORY PARTICLES FOR BIOMEDICAL USES  
The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a...
US20180140453 ORTHOSIS TO MITIGATE SCISSORING GAIT IN CEREBRAL PALSEY PATIENTS  
An embodiment in accordance with the present invention provides an orthotic device that provides a physical barrier between the thighs of the user. The orthotic device provides a physical barrier...
9976184 Mutations in pancreatic neoplasms  
To help reveal the pathogenesis of these lesions, we purified the DNA from Intraductal Papillary Mucinous Neoplasm (IPMN) cyst fluids from 19 patients and searched for mutations in 169 genes...
US20180138106 Superlattice Structures for Thermoelectric Devices  
Example superlattice structures and methods for thermoelectric devices are provided. An example structure may include a plurality of superlattice periods. Each superlattice period may include a...
US20180136220 CORRELATED PEPTIDES FOR QUANTITATIVE MASS SPECTROMETRY  
Described herein are methods for identifying signature peptides for quantifying a polypeptide of interest in a sample. The methods include cleaving the polypeptide into peptides; detecting a...
US20180134753 BIOMIMETIC PEPTIDE AND BIODEGRADABLE DELIVERY PLATFORM FOR THE TREATMENT OF ANGIOGENESIS- AND LYMPHANGIOGENESIS-DEPENDENT DISEASES  
Mimetic peptides having anti-angiogenic and anti-tumorigenic properties and methods of their use for treating cancer, ocular diseases, such as age-related macular degeneration, and...
US20180133348 NUCLEAR IMAGING AND RADIOTHERAPEUTICS AGENTS TARGETING CARBONIC ANHYDRASE IX AND USES THEREOF  
Highly potent and selective radionuclide-based imaging and therapy agents targeting carbonic anhydrase IX with minimum non-specific organ uptake are disclosed. Methods of imaging and/or treating...
9970058 Digital amplification  
The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential,...
9969684 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors  
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
9968280 Method for insertion of a medical device within a body during a medical imaging process  
A method for tracking movement of a movable portion of an interventional device disposed within a natural or artificial body opening is provided. In particular, image data of fiducials is acquired...
US20180127719 COMPOSITIONS AND METHODS FOR IMPLANTATION OF PROCESSED ADIPOSE TISSUE AND PROCESSED ADIPOSE TISSUE PRODUCTS  
The invention provides compositions and methods for the preparation of processed adipose tissue. The invention further provides methods of use of the processed adipose tissue.
US20180125874 Compositions and Methods to Accelerate Resolution of Acute Lung Inflammation  
The present invention provides methods and compositions for treatment of acute inflammatory diseases or disorders and/or for treatment of lung injury. Certain exemplary methods involve...
US20180125818 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA  
The invention relates to methods and compositions for treating schizophrenia or bipolar disorder (in particular, mania) by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and...
US20180125596 Manipulator Device and Therapeutic and Diagnostic Methods  
Dexterous manipulation devices are provided having an end effector enabling large curvature with a diameter of 1 mm or less that can articulate about an axis in a working space of about or less...