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US20100239562 |
Kv CHANNELS IN NEURODEGENERATION AND NEUROPROTECTION
A family of potassium channels (Kv) are expressed in neurons when they are damaged. Blockers of these channels protect neurons from several different types of insults, whether due to disease or...
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7800366 |
Three dimensional magnetic resonance motion estimation on a single image plane
Three-dimensional MR motion estimation on a single image plane based on tagged MRI and HARP processing. Tagged magnetic resonance imaging technique encodes and automatically tracks displacement of...
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7799568 |
Authentication of products using molecularly imprinted polymers
A method for identifying a product includes providing a solid body (10) fabricated from at least a molecularly imprinted polymer having molecular sized cavities (12) adapted to selectively receive...
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7799528 |
Therapeutic and diagnostic applications of genes differentially expressed in lympho-hematopoietic stem cells
The invention is based at least in part on the discovery of novel group of genes and/or their encoded gene products that are differentially represented in two substantially enriched...
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US20100234856 |
ROTATING NEEDLE DRIVER AND APPARATUSES AND METHODS RELATED THERETO
Featured is a medical instrument driver, a robotic apparatus embodying such a medical instrument driver and methods related thereto for inserting a medical instrument into tissue of a mammal (e.g.,...
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US20100230629 |
PIEZOELECTRIC COMPOSITIONS
Piezoelectric compositions are provided wherein mechanical and piezoelectric properties can be separately modulated. Preferred compositions include resin blends that comprise: (a) a...
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7795026 |
Methods for obtaining human embryoid body-derived cells
The invention is directed to novel cells that are derived from human embryoid bodies. Such embryoid body-derived (EBD) cells are relatively uncommitted or progenitor (e.g., pluripotent) cells. EBD...
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7794998 |
Primate T-lymphotropic viruses
Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central...
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7794929 |
Genomic screen for epigenetically silenced genes associated with cancer
A method of identifying epigenetically silenced genes, e.g., methylation silenced genes, in cancer cells is provided. In addition, methods of identifying a cancer by detecting epigenetic silencing...
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US20100229250 |
TREATMENT AND PREVENTION OF ISCHEMIC BRAIN INJURY
The invention provides methods of identifying agents for treating and preventing ischemic brain injury.
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US20100228104 |
CEREBRAL VASCULAR REACTIVITY MONITORING
A monitoring device may include logic to receive arterial blood pressure data associated with a patient and receive tissue hemoglobin data associated with the patient. The logic may also calculate...
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US20100227836 |
PARENTERAL ADMINISTRATION OF A GLUCOSAMINE
Materials and methods for local delivery of a glucosamine are provided to facilitate bone and cartilage growth.
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US20100222667 |
COMPRESSION DEVICE FOR ENHANCING NORMAL/ABNORMAL TISSUE CONTRAST IN MRI INCLUDING DEVICES AND METHODS RELATED THERETO
Featured are a device for compression of target tissue while magnetic resonance imaging the target tissue and methods and systems related thereto. The method includes disposing target tissue...
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US20100221250 |
METHODS OF TREATING BRAIN TUMORS WITH ANTIBODIES
The application is directed toward a method of treating a brain tumor in a patient comprising systemically administering a monoclonal antibody.
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7787930 |
Adiabatic T2 preparation sequence for magnetic resonance imaging with reduced B1 sensitivity
Adiabatic pulses that define an amplitude modulation and a frequency modulation are applied in a sequence of pulses to obtain a T2 weighted magnetic resonance image. Such an adiabatic T2 prep...
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7785564 |
Design and synthesis of renal dipeptidase inhibitors
Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent...
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US20100215580 |
Compositions and methods for enhancing transport through mucus
The invention generally relates to compositions and methods for transporting substances across mucosal barriers. The invention also relates to methods of making and using such substances.
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7781161 |
Genomic screen for epigenetically silenced tumor suppressor genes
Methods of genomic screening to identify epigenetically silenced genes, including epigenetically silenced tumor suppressor genes are provided. Also provided are methods of detecting a cancer, for...
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7780596 |
Non-invasive health monitor
The time between heartbeats is measured over a series of such heartbeats. The time interval between two successive events is calculated and stored as a first array. The time difference between...
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US20100210602 |
PhoU (PerF), A PERSISTENCE SWITCH INVOLVED IN PERSISTER FORMATION AND TOLERANCE TO MULTIPLE ANTIBIOTICS AND STRESSES AS A DRUG TARGET FOR PERSISTER BACTERIA
The PhoU protein is a widely expressed protein in bacteria, but not in eukaryotes. The PhoU protein is required for persister formation in bacteria. The invention includes compositions to reduce...
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US20100209947 |
Free human serum IgE immunoenzymetric assay and methods of use
The present invention relates to the development of novel of free blood fluid IgE Immunoenzymetric assay that is specifically designed to evaluate the blood fluid of patients on therapeutic agents...
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US20100209921 |
Digital Amplification
The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential,...
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7778682 |
Biopsy and sampling needle antennas for magnetic resonance imaging-guided biopsies
Herein is disclosed a magnetic resonance imaging antenna, including an inner conductor, an outer shield slideably displaceable with respect to the inner conductor, and an insulator electrically...
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7776565 |
Engineering intracellular sialylation pathways
Methods for manipulating carbohydrate processing pathways in cells of interest are provided. Methods are directed at manipulating multiple pathways involved with the sialylation reaction by using...
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US20100204100 |
BIOLOGICAL AGENTS ACTIVE IN CENTRAL NERVOUS SYSTEM
Cell-permeant fusion peptides Tat-PDZ can dose-dependently reduce the threshold for anesthesia. PDZ domain-mediated protein interactions at synapses in the central nervous system play an important...
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US20100203518 |
Quantitative Assay for the Simultaneous Detection and Speciation of Bacterial Infections
An adaptation of the real-time PCR assay allows for highly sensitive detection of any eubacterial species with simultaneous speciation. The assay relies on a ‘multiprobe’ design in which a sin...
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US20100203110 |
Therapeutics for Cancer Using 3-Bromopyruvate and Other Selective Inhibitors of ATP Production
The present invention relates to methods of treating a cancerous tumor in a subject comprising administering to the subject an effective amount of 3-bromopyruvate. The 3-bromopyruvate may be...
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US20100203047 |
Novel Compositions And Methods For Stimulating Erythropoiesis In A Mammal
The present invention relates to compositions comprising an agent which activates herpes virus entry mediator (HVEM). The present invention also relates to compositions comprising an agonist of...
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US20100202970 |
INTRACELLULAR REPORTERS
The invention provides a variety of molecular tools for use in live-cell tracking of activities of biomolecules and in high-throughput drug screening.
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US20100198104 |
SYSTEM FOR DIAGNOSIS AND THERAPY OF GAZE STABILITY
A system to measure a subject's gaze stability, comprising: a display device; a data processor in communication with the display device; a data input device in communication with the data...
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US20100198068 |
ROBUST AND ACCURATE FREEHAND 3D ULTRASOUND
Disclosed is a system and method for computing out of plane motion between two ultrasound images. The method identifies regions of fully developed speckle that are common to the two images,...
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US20100197580 |
PARSTATIN PEPTIDES AND USES THEREOF
The invention provides parstatin peptides, particularly a mammalian parstatin peptide including amino acids 1-26 of full length mammalian parstatin, preferably a human parstatin. The invention...
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US20100197523 |
ABLATION BASED LASER MACHINING OF BIOMOLECULE PATTERNS ON SUBSTRATES
A method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a...
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US20100196394 |
ANTI-CANCER VACCINE COMPOSITION
Combinations of anti-cancer vaccines and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The vaccines may be isolated antigens, groups of antigens, or whole tumor...
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US20100196354 |
GLUTAMATE RECEPTOR ANTAGONISTS AND METHODS OF USE
The present invention relates to methods and compositions for modulating platelet activity by inhibiting or activating glutamate receptors. The invention further relates to preventing or treating...
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US20100194681 |
MANIPULATION DEVICE FOR NAVIGATING VIRTUAL MICROSCOPY SLIDES/DIGITAL IMAGES AND METHODS RELATED THERETO
Featured is a manipulation device the ability to navigate virtual microscopy slides. The device includes an inverted light emitting diode (LED) reflecting light off a textured slide to a...
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7767202 |
Modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules
The invention provides methods and compositions for the modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen...
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US20100190153 |
SINGLE-MOLECULE PCR ON MICROPARTICLES IN WATER-IN-OIL EMULSIONS
Modulation of the viscosity of the oil phase of a microemulsion used for amplification of DNA on a bead increases the homogeneity of product beads and the amount of amplified DNA per bead. Moreover...
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US20100184100 |
Tyrosine Kinome
Protein kinases are important signaling molecules involved in tumorigenesis. Mutational analysis of the human tyrosine kinase gene family (98 genes) identified somatic alterations in −20% of c...
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US20100184032 |
Stem-Progenitor Cell Specific Micro-Ribonucleic Acids and Uses Thereof
Provided herein are methods and compositions for modulating the differentiation of incompletely differentiated cells, such as stem-progenitor cells, e.g., hematopoietic stem-progenitor cells. A...
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7759121 |
Methods for generating hypermutable yeast
Yeast cells are mutagenized to obtain desirable mutants. Mutagenesis is mediated by a defective mismatch repair system which can be enhanced using conventional exogenously applied mutagens. Yeast...
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US20100175629 |
SYSTEMS, APPARATUS AND DEVICES FOR USE IN ANIMAL STUDIES
Featured are various devices, apparatuses and systems for use in connection with animal studies or experimentation as well as methods related thereto. Such devices, apparatuses and systems include...
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US20100175140 |
Leucine-rich repeat kinase (LRRK2) drosophila model for parkinson's disease: wildtype1 (WT1) and G2019S mutant flies
Mutations in the leucine-rich repeat kinase (LRRK2) gene cause late-onset autosomal dominant Parkinson's disease (PD) with pleiomorphic pathology. Previously, we and others found that expression of...
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7749968 |
Peptides for targeting the prostate specific membrane antigen
The invention provides isolated PSMA binding peptides, as well as pharmaceutical compositions thereof. Also provided are diagnostic and therapeutic methods utilizing the PSMA binding peptides, as...
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7749709 |
SOCS-1 gene methylation in cancer
Methods are provided for identifying a cell exhibiting unregulated growth associated with methylation-silenced transcription of a suppressor of cytokine signaling (SOCS)/cytokine-inducible SH2...
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7749443 |
Enhanced sampling device
The present invention is directed to an enhanced sampling device, herein referred to as an ESD, for enhancing the collection efficiency of the SPME method by enhancing the flow of the analytes onto...
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US20100168176 |
NOVEL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME
Compounds having the following general formula, pharmaceutical compositions comprising the compounds, and methods of treating cancer, obesity, and microbial infections using such compositions:...
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US20100167940 |
METHODS FOR IDENTIFYING CANCER RISK
Provided herein are tissue-specific differential methylated regions (T-DMRs) and cancer-related differential methylated regions (C-DMRs) and methods of use thereof. In one embodiment of the...
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US20100167396 |
Application of Anti-Apoptotic Gene Expression in Mammalian Cells for Perfusion Culture
The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell expressing recombinant Factor VIII such that programmed...
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7747044 |
Fusing multimodal biometrics with quality estimates via a bayesian belief network
A Bayesian belief network-based architecture for multimodal biometric fusion is disclosed. Bayesian networks are a theoretically sound, probabilistic framework for information fusion. The...
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