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7468425 |
p40 protein acts as an oncogene
We have discovered p40, the shortest variant of a new human p53 homologue (p40/p51/p63/p73H). We have also found that it plays a role in cancer. Low level amplification of the p40 locus accompanied...
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7468274 |
Single cell analysis of HIV replication capacity and drug resistance
A novel single-cell-level phenotypic assay is described, which can simultaneously analyze HIV-1 drug susceptibility and intrinsic replication capacity. This allows quantitative dissection of the...
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US20080313754 |
Method for generating hypermutable organisms
Dominant negative alleles of human mismatch repair genes can be used to generate hypermutable cells and organisms. By introducing these genes into cells and transgenic animals, new cell lines and...
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US20080312326 |
Method for the Prevention and/or Treatment of Neurodegenerative Diseases Characterized by Administering and Ep1 Receptor Antagonist
The present invention relates to the use of EP1 receptor antagonists for the treatment of neurodegenerative diseases, for example, Alzheimer's disease, Parkinson's disease, Parkinson syndrome,...
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US20080311673 |
Biomarkers for Breast Cancer
The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying breast cancer status in a patient. In particular, the biomarkers of this invention...
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7465050 |
Method and apparatus for three-dimensional video-oculography
A device for measuring the three-dimensional movements of an eye includes: (a) a mark array that identifies prescribed positions on the eye whose movements are to be measured, (b) a digital camera...
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US20080306384 |
Apparatus and method for computing 3D ultrasound elasticity images
Disclosed is a system and method for computing ultrasound 3D elasticity images. The method includes acquiring ultrasound RF data in a rest state, in which substantially no pressure is applied to a...
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US20080305490 |
AMPLIFICATION OF HUMAN MDM2 GENE IN HUMAN TUMORS
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting...
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7462457 |
Identification of activated receptors and ion channels
The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels.
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7459481 |
Stimulation of CPT-1 as a means to reduce weight
This invention provides methods and compositions for inducing weight loss and maintaining optimum weight comprising administering an agent that stimulates carnitine palmitoyl transferase-1 (CPT-1)...
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7458248 |
Method and apparatus to detect genuine or hoax contaminants
A system (100) and method for detecting contaminants in parcels or other mailings (110). The contaminants, either genuine or hoax, are detected using the system (100) that includes a jogger (140)...
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US20080293626 |
Pigment epithelium-derived factor as a therapeutic agent for vascular leakage
The present invention relates to method of treating a patient with a condition involving increased vascular permeability or increased angiogenesis comprising administering to the patient a...
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7455408 |
Method and apparatus for reducing visual aberrations
A light source is situated on a headgear device and placed to direct light toward the pupil of the eye at an intensity that causes the iris to constrict, resulting in a smaller pupil. This prevents...
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US20080287342 |
Compositions Comprising Modified Collagen and Uses Therefor
The invention provides modified collagen and related therapeutic and diagnostic methods.
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US20080284427 |
Chemical Exchange Saturation Transfer Based Mri Using Reporter Genes and Mri Methods Related Thereto
Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention provide...
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US20080283405 |
Method for Producing Patterned Structures by Printing a Surfactant Resist on a Substrate for Electrodeposition
Methods for electrodeposition of conductive material on a conductive substrate that contains a pattern of a chemisorbed surfactant formed by a stamp having a patterned surface which is pressed onto...
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US20080279864 |
High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel Interactions To Discover New Analgesics
The present invention relates to compositions to treat CaV2 disorders. The invention also relates to methods treating CaV2 disorders. The invention further relates to kits for treating CaV2...
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US20080275219 |
In Vitro Reconstitution of Ribonucleoprotein Complexes, and Methods of Use Therefor
In general, the invention provides methods and compositions for the in vitro production of ribonucleoprotein complexes and related multimolecular complexes useful for cell-free methods of protein...
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US20080269604 |
Ultrasound Calibration and Real-Time Quality Assurance Based on Closed Form Formulation
Disclosed is a system and method for intra-operatively spatially calibrating an ultrasound probe. The method includes determining the relative changes in ultrasound images of a phantom, or...
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US20080267921 |
Cardiac Stem Cells
Human cardiac stem cells can be isolated from endomyocardial biopsies. Such cells mediate cardiac regeneration and improve heart function in a mouse infarct model. The cells can be used for...
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7442513 |
Method of screening for agents that modulate a homer signaling pathway
The invention features a method of identifying, evaluating and screening for compounds or agents for the treatment of disorders involving the Homer signaling pathway in the modulation of...
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7441444 |
AFM cantilevers and methods for making and using same
The invention provides high performance cantilevers with optimal combinations of high resonant frequency and low force constant. In one aspect, AFM cantilevers with spring constants in the range...
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US20080262345 |
Image registration of multiple medical imaging modalities using a multiple degree-of-freedom-encoded fiducial device
Disclosed is a system and method for registering images from two medical imaging modalities in a six-degree-of-freedom coordinate space, for the purpose of providing real time registered imagery...
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US20080261909 |
Gene Delivery to Organs
Application of a virus with poloxamer alone onto atria results in diffuse epicardial gene transfer with negligible penetration into the myocardium. Progressive increases in protease concentration,...
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US20080260765 |
HPV DNA Vaccines and Methods of Use Thereof
Human papillomavirus (HPV) infection is the etiological factor for cervical cancer. Provided are HPV vaccines that generate a humoral immune response to prevent new infection, as well as...
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US20080260758 |
UNIVERSAL GM-CSF EXPRESSING BYSTANDER HUMAN K562 CELL LINE
The present invention provides a universal immunomodulatory cytokine-expressing bystander cell line, a composition comprising such a cell line and a cancer antigen, a method of making such a cell...
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US20080260722 |
Method for High Efficiency Survival/Proliferation of Human Embyonic Stem Cells and Human Embryo Survival in Culture
The present invention provides a role for neurotrophins in hES cell survival and important new insights into the molecular mechanisms controlling the growth of these cells. Although previous...
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US20080260705 |
Preventing Arrhythmias Associated with Cell Transplantation
Skeletal myoblasts are an attractive cell type for transplantation since they are autologous and resistant to ischemia. However, clinical trials of myoblasts transplantation in heart failure have...
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US20080258054 |
Point-of-Care Mass Spectrometer System
A point-of-care mass spectrometer system has a sampling system, an ionization component structured to receive a sample for analysis from the sampling system, a mass analyzer structured to receive a...
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US20080255059 |
Regulators of the hedgehog pathway, compositions and uses related thereto
The present invention makes available, inter alia, methods and reagents for modulating smoothened-dependent pathway activation. In certain embodiments, the subject methods can be used to counteract...
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7435010 |
High temperature light guide
Disclosed is a method of forming an optical monitoring or transmitting light guide and a resulting apparatus that begins by bonding a bundle of optical fibers together using an epoxy and polishing...
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7432246 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-ac...
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US20080244760 |
Transgenic Frog Lines and Assays Employing Them
Rhodopsin transgenes driven by rhodopsin promoters were produced, some attached to GFP coding sequences as a fusion construct. When the resulting transgenes were introduced into Xenopus laevis, the...
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US20080241830 |
Digital amplification
The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and clinical applications. The exponential,...
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US20080241132 |
BRAF Mutation T1796A in Thyroid Cancers
The BRAF gene has been found to be activated by mutation in human cancers, predominantly in malignant melanoma. We tested 476 primary tumors, including 214 lung, 126 head and neck, 54 thyroid, 27...
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7429250 |
CPR chest compression monitor and method of use
Chest compressions are measured and prompted to facilitate the effective administration of CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of...
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7427476 |
PITX2 polynucleotide, polypeptide and methods of use therefor
A novel T-type calcium channel (CACNA1G) is provided, as are polynucleotides encoding the same. CACNA1G has been implicated in cellular proliferative disorders. More specifically, it has been...
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US20080221056 |
Early Detection and Prognosis of Colon Cancers
We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island hypermethylation and transcriptional silencing in colorectal cancer (CRC). By screening cell lines...
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7422568 |
Device, systems and methods for localized heating of a vessel and/or in combination with MR/NMR imaging of the vessel and surrounding tissue
Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel....
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US20080209388 |
Systems and Methods for Providing Higher Assurance Software Construction via Aspects
There are provided systems and methods for integrating requirements driven security code into an application system. The security code is integrated into an application system in such a way as to...
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US20080208266 |
System and Method for Treating Nausea and Vomiting by Vagus Nerve Stimulation
A system and method for treating nausea and vomiting are provided, including one or more electrodes (10, 12) applied on or under the skin, the electrodes being connected to an external current...
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US20080208034 |
Device, systems and methods for localized heating of a vessel and/or in combination with mr/nmr imaging of the vessel and surrounding tissue
Featured are devices, systems and methods for localized heating of a vessel as well as devices, systems and methods for MR/NMR imaging of a vessel while locally heating a portion of the vessel....
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US20080207532 |
Use of Nordihydroguaiaretic Acid Derivatives in the Treatment of Drug Resistant Cancer, Viral and Microbial Infection
Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in...
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US20080204966 |
Controlled Transport and Assembly of Nanostructures
Systems and methods for manipulating nanostructures, such as nanospheres, nanodisks, nanowires, and nanotubes. The systems and methods permit the construction of nano-scale contacts, scaffolds, and...
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7417156 |
Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers
In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily...
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7416703 |
Polymer based lanthanide luminescent sensors for the detection of organophosphorus compounds
A device for measuring and detecting the organophosphonis compounds, such as a pesticides or a nerve agents is provided. The devices function by selectively binding an organophosphorous compound to...
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7416019 |
Thermal interface and switch using carbon nanotube arrays
Thermal interfaces and methods include an array of carbon nanotubes aligned substantively perpendicularly from a substrate. One method includes arranging metal catalyst particles with a particular...
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US20080199531 |
Methods And Products For Delivering Biological Molecules To Cells Using Multicomponent Nanostructures
This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired...
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US20080199442 |
Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors
The use of recombinant adeno-associated virus (AAV) virions for delivery of DNA molecules to muscle cells and tissue is disclosed. The invention allows for the direct, in vivo injection of...
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US20080199061 |
Quantitative Single Image-Based Magnetization Transfer Weighted Imaging Using an Inter-Subject Normalization Reference Within the Image
Disclosed is a system and method for generating quantitative imagery of demyelination in the spinal cord. The method includes acquiring a magnetization transfer weighted (MTw) MR image of the...
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