Patents and Patent Applications from Indiana University ARTI


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US20180194827 INSULIN-INCRETIN CONJUGATES  
Disclosed herein are insulin agonist peptides conjugated to a glucagon analog wherein the insulin/glucagon conjugate is targeted to liver tissues upon administration to a patient.
10020500 Carbonized polyaniline-grafted silicon nanoparticles encapsulated in graphene sheets for li-ion battery anodes  
A method for producing a graphene-composite material, including removing any oxide layer from each of a plurality of silicon nanoparticles, forming a polyaniline layer over each clean silicon...
US20180184630 TRANSGENIC PIGS WITH GENETIC MODIFICATIONS OF SLA  
The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are...
10013894 Bicycle apparatuses for use in automotive testing  
An apparatus for repetitive use in automotive testing includes a body. The body includes a torso and a pair of legs. Each leg includes an upper portion and a lower portion pivotably connected to...
US20180181701 PREDICTING SUICIDALITY USING A COMBINED GENOMIC AND CLINICAL RISK ASSESSMENT  
Biomarkers and methods for screening expression levels of the biomarkers for predicting suicidality (referred herein to suicidal ideation and actions, future hospitalizations and suicide...
US20180179220 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS  
The invention provides novel nicotinic acetylcholine receptor agonists, for example, phantasmidine and derivatives thereof, for example a compound of formula I. Also disclosed are methods of...
US20180177758 COMPOUNDS FOR TREATMENT OF ANGIOGENESIS-MEDIATED DISEASES  
Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular...
10006913 Fluorescent-HAP: a diagnostic stain for HBV cores in cells  
Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described....
US20180170862 PROTEIN TYROSINE PHOSPHATASES OR SHP2 INHIBITORS AND USES THEREOF  
Small molecule compounds derived from α-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine...
US20180170861 SMALL MOLECULE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES AND USED THEREOF  
Small molecule compounds derived from α-sulfophenylacetic amide (SPAA) are provided as novel sulfonic acid based pTyr mimetics. These compounds effectively inhibit a variety of protein tyrosine...
US20180167436 ADAPTIVE VIDEO STREAMING OVER PREFERENCE-AWARE MULTIPATH  
A processor performing functions of a video client may measure an occupancy of a video buffer, select a video chunk having a first video encoding bitrate based upon the occupancy, and provide a...
US20180165510 METHOD AND APPARATUS FOR 3D FACIAL RECOGNITION  
The present disclosure relates to methods and apparatuses for 3-D facial recognition using the Fast Multipole Method (FMM).
9998684 Method and apparatus for virtual 3D model generation and navigation using opportunistically captured images  
A method and device for opportunistically collecting images of a location via a mobile device, the device including algorithms that allow the selective winnowing of collected images to facilitate...
US20180153146 Double Knockout (GT/CMAH-KO) Pigs, Organs and Tissues  
The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are...
US20180148720 INHIBITION OF LNCRNA HOTAIR AND RELATED MATERIALS AND METHODS  
Embodiments disclosed herein concern compositions and methods for treating a condition characterized by overexpression of long non-coding RNA HOTAIR. In certain embodiments, synthetic...
US20180147229 MATERIALS AND METHODS FOR TREATING BACTERIAL INFECTIONS USING C-1 GENTAMICIN  
Various aspects relate to the use of C-1 gentamicin as an antibiotic effective for the treatment of a bacterial infection, a genetic disorder, or cancer in a subject.
US20180139937 CELL CULTURE SYSTEMS FOR PRODUCING IL-33 INDUCED T9 CELLS AND METHODS OF USING THE CELLS  
Cell culture systems for producing IL-33 induced T9 cells and methods of using the IL-33 induced T9 cells (T9IL-33 cells) in a cell therapy for increasing anti-tumoral activity following...
9974759 Beta 2 adrenoceptor antagonists for treating orthostatic hypotension  
Methods of treating orthostatic hypotension are disclosed. The methods include administering to a subject in need thereof an effective amount of a beta 2 (β2) adrenoceptor antagonist, and in...
US20180133175 QUINONE COMPOUNDS FOR TREATING APE1 MEDIATED DISEASES  
The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and...
9968650 Modified viral structural protein with antiviral activity  
This disclosure provides a novel strategy to cope with chronic virus infection by introducing a dominant negative viral structural protein to disturb effective virion production. The dominant...
US20180117250 SYSTEM FOR MANAGING GLUCOSE LEVELS IN PATIENTS WITH DIABETES OR HYPERGLYCEMIA  
A blood glucose maintenance system for use by hyperglycemic individuals measures their blood glucose level and calculates an appropriate glucose or insulin dosage based on the measurement. Recheck...
US20180117114 PEPTIDES THAT MODULATE THE EFFECT OF THE CRMP: NEUROFIBROMIN COMPLEX ON SYNAPTIC TRANSMISSION  
The present disclosure relates generally to materials and methods for studying and treating neurofibromatosis type 1 (NF1) by modulating the interaction of CRMP-2 and neurofibromin. Some...
9956189 Material and methods for treating developmental disorders including comorbid and idiopathic autism  
The present invention is directed to a method of treating a subject with autism spectrum disorder by administering an acetylaminopropane sulfonate. The acetylaminopropane sulfonate may have the...
US20180111987 MONOCLONAL ANTIBODY AND ANTIGENS FOR DIAGNOSING AND TREATING LUNG DISEASE AND INJURY  
The present invention provides methods for diagnosing a patient with emphysema, COPD of lung injury caused by tobacco use by detecting the levels of EMAP II in a sample. Disclosed herein are the...
US20180105569 ANALOGS OF GLUCAGON EXHIBITING GIP RECEPTOR ACTIVITY  
Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the...
US20180102535 Rechargeable Alkaline Metal And Alkaline Earth Electrodes Having Controlled Dendritic Growth And Methods For Making And Using Same  
A device for extending the life of a battery, including an electrode having a metal portion, wherein the metal portion is selected from the group including lithium, calcium, magnesium, sodium,...
US20180099952 HEPATITIS B VIRAL ASSEMBLY EFFECTORS  
Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral...
9926562 Methods for preventing and treating chronic kidney disease (CKD)  
The present invention relates to methods for preventing and treating chronic kidney disease (CKD).
US20180079998 FLOW ASSEMBLY FOR CELLS  
In one embodiment, a flow assembly for cells comprises a first flow path configured to receive a plurality of cells, a second flow path configured to receive a buffer, and a third flow path...
US20180078559 TARGETING cGMP-RELATED PHOSPHODIESTERASES TO REDUCE CYST FORMATION IN CYSTIC KIDNEY DISEASE, AND RELATED MATERIALS AND METHODS  
Described herein is the identification of cGMP-specific phosphodiesterase upregulation in cystic kidney diseases. Also described is the use of cGMP-specific phosphodiesterase inhibitors for...
9920689 Hybrid wave rotor propulsion system  
A hybrid propulsion system includes a wave rotor combustion engine operating in parallel with an electrical motor-generator element. The motor-generator element is coupled to the turbine shaft to...
US20180071252 METHODS OF TREATING AUTOIMMUNE AND/OR GLOMERULONEPHRITIS-ASSOCIATED DISEASES USING SHP2 INHIBITORS  
Methods are disclosed herein for administering a oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitor for treating autoimmune and/or...
US20180070966 ULTRASOUND CATHETER  
A system and a method for disrupting an occlusion within a blood vessel is provided The system includes an elongated catheter body having a proximal portion, a distal portion, and a first lumen....
9908877 Imidazo[1,5-a]pyridinium ion fluorophores, and methods of making and using the same  
A fluorophore and methods of detecting cations and hydrophobic environments using the fluorophore are disclosed. The fluorophore includes an imidazo[1,5-a]pyridinium ion core and has the formula...
US20180060485 PRIVACY-PRESERVING SIMILAR PATIENT QUERY SYSTEMS AND METHODS  
Method including securely calculating, by a processor in electrical communication with a genome registry, an edit-distance between a query private genome and a second private genome, and securely...
9902734 Nicotinic acetylcholine receptor agonists  
The invention provides novel nicotinic acetylcholine receptor agonists, for example, phantasmidine and derivatives thereof, for example a compound of formula I. Also disclosed are methods of...
US20180051297 COMPOSITIONS AND SYSTEMS FOR CONFERRING DISEASE RESISTANCE IN PLANTS AND METHODS OF USE THEREOF  
Compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins inside plant cells. Briefly, the...
9895358 Combination therapies for treatment of spinal muscular atrophy  
Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron...
9895100 Eye movement monitoring of brain function  
The present disclosure provides a wearable device for the detection of mild traumatic brain injury, such as concussions, and methods of use thereof. Further disclosed are a method and system for...
US20180048213 HIGH TORQUE DENSITY ELECTRIC MOTOR AND/OR GENERATOR  
An electric motor is disclosed, comprising a stator and a rotor mounted relative to the stator to form a gap between a surface of the stator and a surface of the rotor, the gap having a width. One...
9889280 Rectal catheter configured for pediatric care  
A rectal catheter is configured for improved pediatric care. The catheter includes a member that terminates into a rounded tip, a plug mounted about the member, the plug being made of a moldable...
9888674 Double knockout (GT/CMAH-KO) pigs, organs and tissues  
The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional aGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are...
9887643 Bidirectional electrical signal converter  
A bidirectional AC-to-DC and DC-to-AC circuit includes a first inductor-capacitor (LC) circuit connected to an AC power source, a transistor synchronized with the AC power source signal, a second...
9885059 Ultrahigh throughput microinjection device  
Many applications in cell biology, genetic engineering, cell-based therapeutics, and drug discovery require precise and safe methods for introducing membrane-impermeable molecules into cells. This...
US20180033600 DEVICE AND METHOD FOR ANALYSIS OF BIOFLUIDS BY ION GENERATION USING WETTED POROUS MATERIAL  
The present disclosure provides a mass spectrometry cartridge and methods of use thereof.
US20180030442 MICRORNA THERAPY FOR PANCREATIC CANCER  
Methods for inhibiting pancreatic cancer cell migration and invasion are disclosed herein. Further, methods for inhibiting autophagy are disclosed. More particularly, as discussed herein,...
9877936 Quinone compounds for treating Ape1 mediated diseases  
The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and...
US20180025180 EXTERNAL RESOURCE CONTROL OF MOBILE DEVICES  
The present disclosure provides a security enhanced channel control system useable on a wireless device comprising a policy module including at least one processor and memory, the policy module...
9872863 Targeting primary cilia to treat glaucoma  
Methods for reducing intraocular pressure and treating glaucoma are disclosed. The methods include administering to an individual a composition comprising a TRPV4 agonist.
US20180017561 TH17-PRONE CD146+CCR5+ T-CELL POPULATION AS AN EARLY MARKER OF INTESTINAL GRAFT-VERSUS-HOST DISEASE  
Th17-prone CD146+CCR5+ T-cell population as an early biomarker of intestinal graft-versus-host disease and its use for determining prognosis of intestinal GVHD before the clinical signs are...