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US20120016036 |
MATERIAL AND METHODS FOR TREATING DEVELOPMENTAL DISORDERS INCLUDING COMORBID AND IDIOPATHIC AUTISM
Subjects who were diagnosed with either comorbid or idiopathic autism were treated with acamprosate. Patients generally showed marked improvements in primary outcomes as assessed using, for...
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US20120011156 |
INTER-CLASS MOLECULAR ASSOCIATION CONNECTIVITY MAPPING
Methods, systems, devices and/or apparatuses are provided for computationally deriving molecular association connectivity maps for the study of inter-class molecular associations in toxicogenomics...
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8088395 |
Phytol derived immunoadjuvants and their use in vaccine formulations
This invention relates to a novel immunoadjuvant, an adjuvant component, and vaccines containing the adjuvant component. The adjuvant includes phytol or a phytol derivative. The adjuvant component,...
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US20110311453 |
Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto
An alloyed semiconductor quantum dot comprising an alloy of at least two semiconductors, wherein the quantum dot has a homogeneous composition and is characterized by a band gap energy that is...
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8076298 |
Treating acute renal failure with soluble thrombomodulin variants
The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises administering to the subject soluble...
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US20110301108 |
MATERIALS AND METHODS FOR SENSITIZING MULTIDRUG RESISTANT CELLS
Disclosed herein are materials and methods for sensitizing multidrug resistant cancer cells that express ABCG2 and related proteins members of a family of ATP-binding transporter superfamily that...
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US20110288652 |
MATERIALS AND METHODS FOR TREATING CRITICALLY SIZED DEFECTS IN MOUSE BONE
Scaffolds equipped to include biologically active reagents such as proteins sized and engineered specifically for use in a mouse were made and implanted into mice. The scaffold was specifically...
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US20110288003 |
AMIDE BASED GLUCAGON AND SUPERFAMILY PEPTIDE PRODRUGS
Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an...
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8057421 |
Modular arterio-venous shunt device and methods for establishing hemodialytic angioaccess
The present invention provides an implantable modular AV shunt device, which is capable of monitoring and reporting its own patency, and which comprises a plurality of modular components that may...
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US20110269636 |
MATERIALS AND METHODS FOR IDENTIFYING PATIENTS AT HEIGHTEN RISK FOR DEVELOPING HER2+ RELATED BRAIN TUMORS
Aspects of the invention include methods for identifying patients with HER2+ cancers that are at a heightened risk for developing brain metastasis within three years of having been diagnosed with...
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US20110257462 |
ACTIVE OR PASSIVE ASSISTANCE IN THE CIRCULATORY SYSTEM
Apparatus and methods for assisting flow of a fluid in a conduit. In some embodiments, a viscous impeller rotating within a protective cage provides a boost and total pressure to blood within the...
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US20110257092 |
GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS
Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular...
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8039225 |
Method to identify patients at risk for lung transplant rejection
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one...
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US20110245164 |
YL-BASED INSULIN-LIKE GROWTH FACTORS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR
Insulin-like growth factor analogs are disclosed wherein substitution of the IGF native amino acids, at positions corresponding to positions B16 and B17 of native insulin, with tyrosine and...
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US20110237493 |
DIPEPTIDE LINKED MEDICINAL AGENTS
A non-enzymatically self cleaving dipeptide element is provided that can be linked to known medicinal agents via an amide bond. The dipeptide will spontaneously be cleaved from the medicinal agent...
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8026353 |
Nucleic acid molecules encoding human 4-1BB
The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes...
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US20110218415 |
SYSTEM AND METHOD FOR DETECTING CARDIAC ARRHYTHMIAS FROM HEART NERVE ACTIVITY
A method has been developed that detects cardiac arrhythmia from intrinsic cardiac nerve signals obtained from a heart in a patient. The method includes sampling intrinsic cardiac nerve activity at...
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US20110217258 |
Combined Use of Bendamustine, Doxorubicin and Bortezomib for the Treatment of Multiple Myeloma
Methods for treating multiple myeloma by administering a combination of a proteasome inhibitor, bendamustine and doxorubicin are described.
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8008458 |
Fatty acid phenolic conjugates
This invention relates to a biologically active formulation containing a conjugate of a fatty acid and a complex phenol. The fatty acid can be selected from a variety of fatty acids including acids...
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US20110208162 |
METHODS FOR PREVENTING AGGREGATION OF ADIPOSE STROMAL CELLS
The present invention relates to a methods, compositions, and admixtures which prevent the aggregation of a population of adipose stromal cells (ASCs), such as an isolated population of adipose...
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US20110200600 |
DIAGNOSIS AND PROGNOSIS OF IMMUNE DISORDERS USING STAT4 EXPRESSION
Methods and compositions that determine the expression levels of Stat4α and Stat4β isoforms for therapeutic efficacy of anti-inflammatory treatments, assessing an individual's risk for developing i...
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7997553 |
Automatic retractable floor system for a rotating gantry
A movable floor system for use with a rotating gantry in a radiation treatment facility is provided that comprises a carriage assembly slidably supported within the gantry to maintain a...
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US20110195510 |
csPCNA Isoform Modifications And Uses Thereof
Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through...
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US20110183356 |
METHOD TO IDENTIFY PATIENTS AT RISK FOR LUNG TRANSPLANT REJECTION
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one...
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7981667 |
Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto
An alloyed semiconductor quantum dot comprising an alloy of at least two semiconductors, wherein the quantum dot has a homogeneous composition and is characterized by a band gap energy that is...
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US20110166062 |
GIP-BASED MIXED AGONISTS FOR TREATMENT OF METABOLIC DISORDERS AND OBESITY
Glucagon peptides that exhibit GIP agonist activity in addition to glucagon and/or GLP-I activity are provided. Pharmaceutical compositions comprising such glucagon peptides and therapeutic methods...
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7968345 |
Permethylation of oligosaccharides
A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides,...
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US20110143386 |
METHOD FOR THE ANALYSIS OF O-LINKED OLIOSACHARIDES
A method of analyzing O-linked oligosaccharides in a sample is disclosed. The method comprises the steps of digesting a glycoprotein with a proteolytic enzyme, performing solid-phase permethylation...
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US20110142846 |
METHOD FOR DIAGNOSING AND TREATING EMPHYSEMA
The present invention provides methods for diagnosing a patient with emphysema or COPD by detecting the levels of EMAP II in a sample. Alternatively, methods are provided for determining the...
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7961330 |
Sub-micron surface plasmon resonance sensor systems
A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements...
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7961329 |
Sub-micron surface plasmon resonance sensor systems
A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements...
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7939281 |
Method to identify patients at risk for lung transplant rejection
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one...
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US20110098217 |
COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of...
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US20110098188 |
BLOOD BIOMARKERS FOR PSYCHOSIS
A plurality of biomarkers determine the diagnosis of psychosis based on the expression levels in a sample such as blood. Subsets of biomarkers predict the diagnosis of delusion or hallucination....
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7932023 |
csPCNA isoform modifications and uses thereof
Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through...
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US20110065633 |
ESTER-BASED PEPTIDE PRODRUGS
Prodrug formulations of bioactive polypeptides are provided wherein the bioactive polypeptide has been modified by the linkage of a dipeptide to the bioactive polypeptide through an ester linkage....
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US20110057389 |
FINANCIAL BOARD GAME
A financial board game for use with a targeted population subset, typically including at least one child, is disclosed. The board game includes a board indicating at least one path including a...
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7893408 |
Methods and apparatus for ionization and desorption using a glow discharge
A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying...
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US20110015386 |
PERMETHYLATION OF OLIGOSACCHARIDES
A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides,...
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US20100331246 |
ESTER-BASED INSULIN PRODRUGS
Prodrug formulations of bioactive polypeptides are provided wherein the bioactive polypeptide has been modified by the linkage of a dipeptide to the bioactive polypeptide through an ester linkage....
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7857451 |
System and method for optimizing clinical optic prescriptions
An method and system for determining the appropriate refractive prescription in a clinical optometry or opthalmology setting. Data in the form of aberrometric input, patient history and other...
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7852482 |
Sub-micron surface plasmon resonance sensor systems
A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements...
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7838821 |
Ion mobility spectrometer instrument and method of operating same
An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field activation sources may each be coupled to...
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US20100290309 |
COMPACT MICROFLUIDIC STRUCTURES FOR MANIPULATING FLUIDS
Disclosed is a method and apparatus for manipulating fluids. The apparatus may include a microfluidic structure including inlet channels (1 and 2) and outlet channels (306, 307, 308, 309, 310, 311,...
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US20100285008 |
BENZOQUINONE DERIVATIVE E3330 IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS FOR THE TREATMENT OF CANCER AND ANGIOGENESIS
Disclosed are novel methods for the therapeutic treatment of cancer and angiogenesis. The enzyme Ape1/Ref-1, via its redox function, enhances the DNA binding activity of transcription factors that...
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7831106 |
Laser scanning digital camera with simplified optics and potential for multiply scattered light imaging
A portable, lightweight digital imaging device uses a slit scanning arrangement to obtain an image of the eye, in particular the retina. The scanning arrangement reduces the amount of target area...
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US20100203058 |
DIAGNOSTICS AND THERAPEUTICS BASED ON CIRCULATING PROGENITOR CELLS
Methods and compositions for detection, diagnosis, and therapeutics of arterial diseases based on pro-angiogenic and non-angiogenic circulating hematopoietic stem and progenitor cells (CHSPCs) and...
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US20100193678 |
APPARATUS AND METHODS FOR ANALYZING IONS
An apparatus (10) for separating Ions based on ion mobility includes a conduit (12) defining a closed path. The conduit is configured such that a uniform electric field is produced about the closed...
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US20100190699 |
GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY IN PHYSIOLOGICAL pH BUFFERS
Modified glucagon peptides are disclosed having improved solubility while retaining glucagon agonist activity. The glycogen peptides have been modified by substitution of native amino acids with,...
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7759467 |
Enhanced mediated DNA transfer
A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The...
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