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7618806 |
Methods and apparatus for mass spectral analysis of peptides and proteins
Apparatus, device, and methods for fragmenting high molecular weight molecular ions, such as peptides or proteins, by treating the ions with predetermined wavelengths of light are described. Vacuum...
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US20090234205 |
METHOD AND APPARATUS FOR KIDNEY FUNCTION ANALYSIS
A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second...
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US20090232882 |
PEPTIDE BASED INHIBITION OF caPCNA INTERACTION IN CANCER
Peptides derived from cancer specific isoform of proliferating cell nuclear antigen (caPCNA, also known as csPCNA) or from nmPCNA-interacting proteins interfere with intracellular protein-protein...
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US20090137456 |
GLUCAGON ANALOGS EXHIBITING PHYSIOLOGICAL SOLUBILITY AND STABILITY
Modified glucagon peptides are disclosed having improved solubility and stability, wherein the native glucagon peptide has been modified by pegylation, or the addition of a carboxy terminal peptide...
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7537787 |
Method for modulating glutamate and/or aspartate release in a central nervous system locus
Methods and compositions are disclosed for providing prolonged-release of therapeutic agents by way of in situ stereotaxic implantation in specific loci, including pathways, to treat know...
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US20090104242 |
NIOBIUM OXIDE COMPOSITIONS, NANOSTRUCTURES, BIOACTIVE FORMS AND USES THEREOF
Self-organized niobium oxide nanocones with nano-sized tips are prepared by anodization of niobium in the presence of an electrolyte such as hydrofluoric acid (HF) (aq.). Dimensions and integrity...
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US20090029359 |
DIAGNOSTIC METHODS FOR EARLY CANCER DETECTION
The present disclosure is directed to compositions and methods for detecting signs of telomere dysfunction as diagnostic indicators of metastatic disease. More particularly, diagnostic reagents and...
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US20090017013 |
MOLECULES FOR THE TREATMENT OF LUNG DISEASE INVOLVING AN IMMUNE REACTION TO CONNECTIVE TISSUE FOUND IN THE LUNG
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one...
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US20090006001 |
EMPIRICAL QUANTITATIVE APPROACHES FOR PSYCHIATRIC DISORDERS PHENOTYPES
Psychiatric phenotypes as currently defined are primarily the result of clinical consensus criteria rather than empirical research. A novel approach to characterizing psychiatric phenotypes is...
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7470721 |
Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways
Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.
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US20080312418 |
Antibody Specific for Human 4-1BB Receptor
The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes...
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US20080293845 |
Biodegradable Implant Polymers and Composites
Biodegradable oligomeric polyesters based upon hydroxy acids, such as glycolic acid (GA), lactic acid (LLA), and copolymers thereof are described. Composites that include biodegradable polyesters...
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US20080274557 |
Permethylation Of Oligosaccharides
A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides,...
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US20080250565 |
Relocatable Stereotactic Immobilization Apparatus
A patient immobilization frame is provided that can be secured to a patient table in a radiation therapy facility. The frame includes fiducials integrated into the bottom panel of the frame. The...
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US20080206140 |
Cspcna Isoform Antibodies and Uses Thereof
Antibodies specifically bind only to a cancer specific proliferating cell nuclear antigen (csPCNA) isoform and not to the non-malignant proliferating cell nuclear antigen (nmPCNA) isoform. Methods...
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US20080189859 |
Automatic Retractable Floor System for a Rotating Gantry
A movable floor system for use with a rotating gantry in a radiation treatment facility is provided that comprises a carriage assembly slidably supported within the gantry to maintain a...
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7357509 |
Metrics to predict subjective impact of eye's wave aberration
Several metrics to predict the subjective impact of the eye's wavefront aberrations are presented. The metrics can be based on RMS wavefront errors or slopes, the area of the critical pupil, a...
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7332643 |
Ferritin light subunit variant-encoding nucleic acids, polypeptides, transgenic animals comprising the same, antibodies thereto, and methods of use thereof
Nucleic acids encoding a novel ferritin light chain variant, a ferritin light chain variant polypeptide, ferritin light chain variant polypeptide-specific antibodies, and methods of use thereof are...
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7331669 |
Device for digital retinal imaging
A portable, lightweight digital imaging device uses a slit scanning arrangement to obtain an image of the eye, in particular the retina. The scanning arrangement reduces the amount of target area...
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US20080025956 |
BLOOD VESSEL FORMATION FROM ENDOTHELIAL COLONY FORMING CELLS
Methods and compositions to form fully functional blood vessels in vivo using endothelial colony forming cells (ECFCs) are disclosed. Culturing ECFCs in a support material results in association of...
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7294830 |
Simultaneous acquisition of chemical information
A method and apparatus for operating a mass spectrometer include providing at least two different ion sources, and coupling ion streams simultaneously from the at least two different ion sources to...
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7279105 |
Arrangement and method for performing chromatography
An arrangement for performing chromatography with a mobile phase and a chromatographic bed having a stationary phase is provided. The arrangement includes a support assembly configured to support...
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US20070219156 |
Method of treatment for central nervous system injury
Injuries to the central nervous system, particularly spinal cord injuries, are treated by administering a purine nucleoside or analog to the patient and, optionally, electrically stimulating the...
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7253403 |
Control system for a power supply
A control system ( 12 ) for a power supply ( 14 ), such as a high voltage power supply, includes a control circuit ( 16 ) and a feedback circuit ( 18, 28, 30 ). The feedback circuit ( 18, 28, 30 )...
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7229635 |
Pharmacotherapeutic process and composition for central nervous system disorders
The present invention is directed to a method of modulating the release of at least one endogenous compound in vivo. The method comprises delivering intranasally at least one micro-construct...
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US20070117161 |
Antibody Specific for Human 4-1BB Receptor
The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes...
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US20070111324 |
Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto
An alloyed semiconductor quantum dot comprising an alloy of at least two semiconductors, wherein the quantum dot has a homogeneous composition and is characterized by a band gap energy that is...
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7211603 |
Enediyne compounds and methods related thereto
The invention provides novel tetradentate enediyne ligands that are themselves thermally stable, yet react at about room temperature or slightly higher upon addition of metal ions or under...
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US20070085040 |
Methods and apparatus for mass spectral analysis of peptides and proteins
Apparatus, device, and methods for fragmenting high molecular weight molecular ions, such as peptides or proteins, by treating the ions with predetermined wavelengths of light are described. Vacuum...
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7199110 |
Method of treatment for spinal cord injury
Injuries to the central nervous system, particularly spinal cord injuries, are treated by administering a purine nucleoside or analog to the patient and, optionally, electrically stimulating the...
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US20070072226 |
Mining protein interaction networks
One embodiment is a method including creating a protein interaction network including a plurality of protein IDs and a plurality of interactions between protein IDs, determining confidences of...
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7192785 |
Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and methods of use
The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present...
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7186507 |
Fluorescent in situ RT-PCR
The present invention describes an in situ reverse transcriptase PCR method in which the background fluorescence is greatly reduced as compared to traditional in situ PCR.
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US20070009593 |
Methods of treating cancer
Methods for treating cancer are described herein. The methods include administering to an HIV-negative patient an m-calpain inhibitor such as ritonavir. Ritonavir or other m-calpain inhibitors can...
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7115766 |
Nucleophilic approach for preparing radiolabeled imaging agents and associated compounds
Radiolabeled fluorinated compounds useful for imaging in the diagnosis of Parkinson's Disease are disclosed. Methods and kits for their synthesis are also disclosed.
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7083979 |
Methods for enhanced retroviral-mediated gene transfer
A method to increase the efficiency of transduction of hematopoietic and other cells by retroviruses includes infecting the cells in the presence of fibronectin or fibronectin fragments. The...
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7077944 |
Instrument for separating ions in time as functions of preselected ion mobility and ion mass
An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to...
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7071165 |
LHRH antagonist peptides
Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide...
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7060078 |
Apparatus and method for positive closure of an internal tissue membrane opening
The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall,...
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US20060029595 |
Methods of using human receptor protein 4-1BB
Disclosed herein are the methods of using the H4-1BB protein, ligands to this protein, and various mAbs either directed against H4-1BB or other molecules that can be used therapeutically. The...
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6974863 |
Antibody for 4-1BB
The present invention includes the receptor protein 4-1BB and the cDNA gene encoding for receptor protein 4-1BB. The nucleotide sequence of the isolated cDNA is disclosed herein along with the...
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6956422 |
Generation and measurement of timing delays by digital phase error compensation
A circuit and method for generating a delayed event following a trigger pulse occurring at a random time between clock pulses is disclosed. The circuit includes a clock circuit, a voltage...
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6956208 |
Method and apparatus for controlling position of a laser of a MALDI mass spectrometer
A MALDI mass spectrometer directs a laser shot onto a MALDI sample to generate a sample spectrum which is analyzed to determine if the sample spectrum meets a predetermined criteria. If so,...
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6943256 |
Chiral organic compounds and metal coordination complexes thereof
Disclosed are chiral organic compounds and metal coordination complexes thereof having C 2 symmetry.
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US20050143451 |
Use of parthenolide to inhibit cancer
The invention provides a method comprising the use of parthenolide, including its analogs, to treat cancer or conditions characterized by abnormal angiogenesis.
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6911182 |
Device for placement of effluent
A device for placement of effluent comprises a substrate positioner, a deposition conduit, and a conduit positioner. The substrate positioner supports and positions a substrate on which effluent...
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6890946 |
Use of parthenolide to inhibit cancer
The invention provides a method comprising the use of parthenolide, including its analogs, to treat cancer or conditions characterized by abnormal angiogenesis.
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6881588 |
Fluid treatment device
A fluid treatment device is disclosed for mixing first and second fluids. The first fluid may be a treatment liquid that is contained in a container and that is used to change a property, such as...
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6861647 |
Method and apparatus for mass spectrometric analysis of samples
An MALDI mass spectrometer for the composition analysis of large batch sizes of samples includes a mass spectrometer having an ionization chamber and a sample chamber coupled to the ionization...
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US20040167774 |
Audio-based method, system, and apparatus for measurement of voice quality
A method of diagnosing voices can include processing a test voice signal using an auditory model, determining at least one voice quality attribute from the test voice signal, and comparing the at...
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