Patents and Patent Applications from Indiana University ARTI


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9790263 GIP receptor-active glucagon compounds  
Glucagon peptides with increased GIP activity are provided, optionally with GLP-1 and/or glucagon activity. In some embodiments, C-terminally extended glucagon peptides comprising an amino acid...
9783592 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity  
Provided herein are glucagon superfamily peptides conjugated with NHR ligands that are capable of acting at a nuclear hormone receptor. Also provided herein are pharmaceutical compositions and...
9782491 Peptide conjugates for treating pain  
Described herein are compounds, composition, and methods for treating pain. In particular, described herein compounds, compositions, and methods that modulate the protein-protein-interaction...
US20170283479 LIPIDATED AMIDE-BASED INSULIN PRODRUGS  
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed...
US20170281788 INCRETIN-INSULIN CONJUGATES  
Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor,...
9775854 Materials and methods for treating diseases caused by genetic disorders using aminoglycosides and derivatives thereof which exhibit low nephrotoxicity  
Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts...
US20170279401 ULTRA WIDE SPECTRUM PHOTOVOLTAIC-THERMOELECTRIC SOLAR CELL  
The present invention is a photovoltaic-thermoelectric solar cell and a method of manufacturing a photovoltaic-thermoelectric solar cell. The solar cell includes a substantially transparent...
US20170273609 METHOD AND APPARATUS FOR ASSESSING TISSUE OXYGENATION SATURATION  
A method and apparatus for assessing tissue oxygenation saturation during physical activity comprising the steps of providing at least one near-infrared spectroscopy probe including at least one...
9770423 Modulation sAPP, sAAP α and BDNF levels in individuals diagnosed with FXS and ASD  
A method of treating and monitoring patient diagnosed with Autistic Spectrum disorder or Fragile X syndrome comprising measuring plasma biomarker levels of BDNF, sAPP, and sAPP alpha and adjusting...
US20170267704 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF  
The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer...
US20170266253 ANTITHETICAL REGULATION OF ENDOTHELIAL ACE AND ACE2 BY BRG1-FOXM1 COMPLEX UNDERLIES PATHOLOGICAL CARDIAC HYPERTROPHY  
Methods are disclosed herein for administering a FoxM1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the...
US20170266197 METHODS AND COMPOSITIONS FOR TREATING HEPATITIS B VIRUS INFECTIONS  
Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.
9767580 Apparatuses, methods, and systems for 2-dimensional and 3-dimensional rendering and display of plenoptic images  
Apparatuses, methods and systems for processing, rendering and displaying plenoptic images are disclosed. One exemplary embodiment is a method comprising storing a plenoptic image in a...
US20170261518 BIOMARKERS AND ASSAY TO DETECT CHRONIC GRAFT VERSUS HOST DISEASE  
A four-biomarker panel for diagnosis of chronic graft-versus-host disease (cGVHD) and methods of prognosing and/or diagnosing cGVHD using the biomarker panel are disclosed.
9758562 Glucagon/GLP-1 receptor co-agonists  
Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.
9757350 Small molecule inhibitors of replication protein A that also act synergistically with cisplatin  
Replication protein A (RPA) is a single-strand DNA-binding protein with essential roles in DNA replication, recombination and repair. Small molecule inhibitors (SMIs) with the ability to disrupt...
US20170251646 TRANSGENIC PIGS LACKING ONE OR MORE CELLULAR TRANSPORT GENES  
The application provides methods of improving a medication related side effect in a human after transplant of transgenic organs, tissues or cells from transgenic pigs with a disrupted cellular...
US20170251629 METHOD AND APPARATUS FOR SPATIAL COGNITIVE ASSESSMENT OF A LAB ANIMAL  
The present disclosure relates to a method and apparatus for performing a cognitive bias assay on a lab animal. The apparatus may include a first base member and a second base member spaced apart...
9751835 Processes and intermediates for preparing indole pharmaceuticals  
The invention described herein pertains to processes and intermediates for preparing indole containing pharmaceuticals, particularly to processes and intermediates for preparing selective estrogen...
9750481 System and method for analyzing antegrade and retrograde blood flow  
A computer-implemented method for simultaneously analyzing antegrade and retrograde blood flow is provided. The method is implemented using a computing device including a processor in...
US20170248612 METHODS FOR DETECTING SINUSOIDAL OBSTRUCTIVE SYNDROME (SOS)  
Disclosed are biomarker panels for evaluating subjects at risk of sinusoidal obstruction syndrome (SOS) early after hematopoietic stem cell transplantation (HSCT). In particular, the present...
9745288 Compounds and methods for treating cancer by inhibiting the urokinase receptor  
Compounds and methods for treating or preventing cancer associated with binding to the urokinase receptor are provided. Biological processes affected by the compounds include cell migration, cell...
9744249 Method and apparatus for kidney function analysis  
A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second...
US20170240858 METHODS FOR GENREATING THE INNER EAR AND OTHER CRANIAL PLACODE-DERIVED TISSUES USING PLURIPOTENT STEM CELLS  
Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells...
US20170239225 COMBINATION THERAPIES FOR TREATMENT OF SPINAL MUSCULAR ATROPHY  
Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron...
US20170231548 SYSTEM AND METHOD FOR BLADDER TRANSDUCER PLACEMENT  
A tissue sensing device and a method for placing the device. The device including a first electrically conductive needle; a non-conductive sheath receiving the first needle therein and allowing...
9733258 Biomarker for determining mitochondrial damage in friedreich's ataxia  
Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in...
9730942 Materials and method for inhibiting replication protein A and uses thereof  
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the...
US20170229416 Inter-Chip Alignment  
First, second, and third integrated devices each include one or more interconnecting structure. Each interconnecting structure includes (i) one or more interconnecting nodules extending from an...
US20170227147 CONDUIT IDENTIFICATION TAGS  
An identifier for a conduit includes a first tag having a body with a first aperture formed therein for receiving the conduit and a first identifying feature, and a second tag having a body with a...
US20170226121 MODULATORS OF VIRUS ASSEMBLY AS ANTIVIRAL AGENTS  
In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular...
US20170220743 TRACKING REAL-TIME ASSESSMENT OF QUALITY MONITORING IN ENDOSCOPY  
The present disclosure provides a method for making clinical recommendations, comprising receiving pathology reports by a computing device; processing the pathology reports by the computing device...
US20170215752 SYSTEM AND METHOD FOR NON-INVASIVELY CONTROLLING AUTONOMIC NERVE ACTIVITY  
System and methods for monitoring and/or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subject's...
US20170211039 METHOD FOR PRODUCING RETINAL GANGLION CELLS FROM PLURIPOTENT CELLS  
A method of making retinal ganglion cells, comprises the steps of: (a) differentiating pluripotent stem cells into retinal progenitor cells; and, (b) differentiating retinal progenitor cells into...
US20170209701 SYSTEMS AND METHODS FOR CONTROLLING A VENTRICULAR RATE DURING ATRIAL FIBRILLATION  
Systems and methods for controlling a ventricular rate during atrial fibrillation are provided. In some aspects, a method includes selecting a treatment protocol based on a determined condition of...
9707276 O-glycosylated carboxy terminal portion (CTP) peptide-based insulin and insulin analogues  
Compositions and formulations comprising insulin or insulin analogs comprising a carboxy terminal portion (CTP) peptide comprising amino acids 112-118 to 145 of the beta subunit of human chorionic...
9701621 Poly-cyanostilbene macrocycles  
The present disclosure concerns synthesis and anion binding features of poly-cyanostilbene macrocycles of Formula (I):
US20170191963 ION MOBILITY SPECTROMETER AND METHOD OF OPERATING SAME  
An ion mobility spectrometer instrument has a drift tube that is partitioned into a plurality of cascaded drift tube segments. A number of electric field sources may each be coupled to one or more...
US20170189362 TUNEABLE DELIVERY OF NANOPARTICLE BOUND ACTIVE PLASMIN FOR THE TREATMENT OF THROMBOSIS  
Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule...
US20170182055 MATERIALS AND METHOD FOR INHIBITING REPLICATION PROTEIN A AND USES THEREOF  
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the...
US20170179093 Inter-Chip Alignment  
First and second integrated devices each have an optical component and a plurality of interconnect structures disposed one edge thereon. The first edge surface of the second integrated device is...
9683965 Hybrid ion mobility spectrometer  
A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet at one end and an ion outlet at an opposite end, a multiple-pass drift tube having an ion inlet and an ion...
US20170170487 SYSTEMS AND METHODS OF GRAPHENE SUPPORTED CATALYSTS  
Functionalized graphene comprising graphene, a metal dispersed throughout the graphene, wherein the metal comprises Pt, Rh, Pd, Ag, Au, Ni, Os, Ir, alloys thereof, oxides thereof, or mixtures...
9675641 Materials and methods to enhance hematopoietic stem cells engraftment procedures  
This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that...
US20170162532 Edge Interconnect Packaging of Integrated Circuits for Power Systems  
Disclosed is an integrated circuit packaging system that includes first and second microchips. Each microchip includes a top surface, a surface, one or more quilt package nodules fabricated on...
US20170157426 SYSTEM AND METHOD FOR REDUCING BIOLOGICAL DAMAGE IN PROTON THERAPY  
Systems comprising a processor in electrical communication with a tangible, non-transitory memory that, in response to an execution by the processor, cause the processor to measure a relative...
US20170155129 HIGH-ENERGY RECHARGEABLE LITHIUM-SULFUR BATTERIES  
Methods of manufacturing comprising placing a mixture comprising sulfur powder, a carbon nanotube, an alcohol soluble binder, and a solvent into a cast and removing a solvent from the mixture to...
9666103 Conduit identification system  
An identifier for a conduit includes a substrate having a pair of apertures. The substrate further contains a frangible portion encompassing one of the apertures and having a shape that...
US20170148097 SYSTEMS AND METHODS FOR DERIVING FINANCIAL INFORMATION FROM EMOTIONAL CONTENT ANALYSIS  
Method of deriving financial information comprising gathering, by a processor, information from a plurality of social media accounts, associating, by the processor, the information from the...
9660995 Methods, systems, and computer readable media for combating device theft with user notarization  
The subject matter described herein includes methods, systems, and computer readable media for combating mobile device theft with user notarization. One method includes providing a supplicant...