Patents and Patent Applications from Indiana University ARTI


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US20120122783 GLUCAGON ANTAGONISTS  
Glucagon antagonists are provided which comprise amino acid substitutions and/or chemical modifications to glucagon sequence. In one embodiment, the glucagon antagonists comprise a native glucagon...
8169615 Sub-micron surface plasmon resonance sensor systems  
A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements...
US20120100112 MATERIALS AND METHODS FOR USING ADIPOSE STEM CELLS TO TREAT LUNG INJURY AND DISEASE  
The present invention provides methods for treating patients with acute or chronic lung disease or injury to the lungs including injury caused by exposure to cigarette smoke other irritants or...
8163691 Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways  
Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling.
US20120093776 METHODS FOR TREATING DISEASES USING A BONE MORPHOGENETIC PROTEIN  
Described herein are methods, uses, and pharmaceutical compositions for treating heart disease that include a bone morphogenetic protein (BMP). In addition, described herein are methods, uses, and...
US20120088720 INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES  
Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using...
US20120059305 ARTERIOVENOUS SHUNT WITH INTEGRATED SURVEILLANCE SYSTEM  
A hemodialytic angioacess device for implantation in dialysis patients, comprising an arteriovenous (AV) shunt, anastomotic valves that connect the AV shunt to blood vessels, a valve control system...
US20120052081 COMPOSITIONS FOR USE IN THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASES AND ASTHMA  
The present invention provides compounds and methods for treating or preventing pulmonary diseases include COPD and asthma. In particular, the present invention provides for compounds comprising...
8124389 Crystal structure of aldehyde dehydrogenase and methods of use thereof  
The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising...
US20120038885 DEVICES AND METHODS FOR POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY AND ADAPTIVE OPTICS  
The present disclosure includes disclosure of devices, and methods to resolve microscopic structures. In at least one exemplary embodiment, a visualization apparatus comprises a source arm having a...
US20120016036 MATERIAL AND METHODS FOR TREATING DEVELOPMENTAL DISORDERS INCLUDING COMORBID AND IDIOPATHIC AUTISM  
Subjects who were diagnosed with either comorbid or idiopathic autism were treated with acamprosate. Patients generally showed marked improvements in primary outcomes as assessed using, for...
US20120011156 INTER-CLASS MOLECULAR ASSOCIATION CONNECTIVITY MAPPING  
Methods, systems, devices and/or apparatuses are provided for computationally deriving molecular association connectivity maps for the study of inter-class molecular associations in toxicogenomics...
8088395 Phytol derived immunoadjuvants and their use in vaccine formulations  
This invention relates to a novel immunoadjuvant, an adjuvant component, and vaccines containing the adjuvant component. The adjuvant includes phytol or a phytol derivative. The adjuvant component,...
US20110311453 Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto  
An alloyed semiconductor quantum dot comprising an alloy of at least two semiconductors, wherein the quantum dot has a homogeneous composition and is characterized by a band gap energy that is...
8076298 Treating acute renal failure with soluble thrombomodulin variants  
The present invention provides a method for preventing and/or treating subjects with acute renal failure caused by a variety of conditions. The method comprises administering to the subject soluble...
US20110301108 MATERIALS AND METHODS FOR SENSITIZING MULTIDRUG RESISTANT CELLS  
Disclosed herein are materials and methods for sensitizing multidrug resistant cancer cells that express ABCG2 and related proteins members of a family of ATP-binding transporter superfamily that...
US20110288652 MATERIALS AND METHODS FOR TREATING CRITICALLY SIZED DEFECTS IN MOUSE BONE  
Scaffolds equipped to include biologically active reagents such as proteins sized and engineered specifically for use in a mouse were made and implanted into mice. The scaffold was specifically...
US20110288003 AMIDE BASED GLUCAGON AND SUPERFAMILY PEPTIDE PRODRUGS  
Prodrug formulations of glucagon superfamily peptides are provided wherein the glucagon superfamily peptide has been modified by the linkage of a dipeptide to the glucagon superfamily through an...
8057421 Modular arterio-venous shunt device and methods for establishing hemodialytic angioaccess  
The present invention provides an implantable modular AV shunt device, which is capable of monitoring and reporting its own patency, and which comprises a plurality of modular components that may...
US20110269636 MATERIALS AND METHODS FOR IDENTIFYING PATIENTS AT HEIGHTEN RISK FOR DEVELOPING HER2+ RELATED BRAIN TUMORS  
Aspects of the invention include methods for identifying patients with HER2+ cancers that are at a heightened risk for developing brain metastasis within three years of having been diagnosed with...
US20110257462 ACTIVE OR PASSIVE ASSISTANCE IN THE CIRCULATORY SYSTEM  
Apparatus and methods for assisting flow of a fluid in a conduit. In some embodiments, a viscous impeller rotating within a protective cage provides a boost and total pressure to blood within the...
US20110257092 GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS  
Modified glucagon peptides are disclosed having enhanced potency at the glucagon receptor relative to native glucagon. Further modification of the glucagon peptides by forming intramolecular...
8039225 Method to identify patients at risk for lung transplant rejection  
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one...
US20110245164 YL-BASED INSULIN-LIKE GROWTH FACTORS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR  
Insulin-like growth factor analogs are disclosed wherein substitution of the IGF native amino acids, at positions corresponding to positions B16 and B17 of native insulin, with tyrosine and...
US20110237493 DIPEPTIDE LINKED MEDICINAL AGENTS  
A non-enzymatically self cleaving dipeptide element is provided that can be linked to known medicinal agents via an amide bond. The dipeptide will spontaneously be cleaved from the medicinal agent...
8026353 Nucleic acid molecules encoding human 4-1BB  
The human receptor H4-1BB has been isolated, sequenced and disclosed herein. The cDNA of the human receptor H4-1BB is about 65% homologous to the mouse cDNA 4-1BB and was isolated by using probes...
US20110218415 SYSTEM AND METHOD FOR DETECTING CARDIAC ARRHYTHMIAS FROM HEART NERVE ACTIVITY  
A method has been developed that detects cardiac arrhythmia from intrinsic cardiac nerve signals obtained from a heart in a patient. The method includes sampling intrinsic cardiac nerve activity at...
US20110217258 Combined Use of Bendamustine, Doxorubicin and Bortezomib for the Treatment of Multiple Myeloma  
Methods for treating multiple myeloma by administering a combination of a proteasome inhibitor, bendamustine and doxorubicin are described.
8008458 Fatty acid phenolic conjugates  
This invention relates to a biologically active formulation containing a conjugate of a fatty acid and a complex phenol. The fatty acid can be selected from a variety of fatty acids including acids...
US20110208162 METHODS FOR PREVENTING AGGREGATION OF ADIPOSE STROMAL CELLS  
The present invention relates to a methods, compositions, and admixtures which prevent the aggregation of a population of adipose stromal cells (ASCs), such as an isolated population of adipose...
US20110200600 DIAGNOSIS AND PROGNOSIS OF IMMUNE DISORDERS USING STAT4 EXPRESSION  
Methods and compositions that determine the expression levels of Stat4α and Stat4β isoforms for therapeutic efficacy of anti-inflammatory treatments, assessing an individual's risk for developing i...
7997553 Automatic retractable floor system for a rotating gantry  
A movable floor system for use with a rotating gantry in a radiation treatment facility is provided that comprises a carriage assembly slidably supported within the gantry to maintain a...
US20110195510 csPCNA Isoform Modifications And Uses Thereof  
Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through...
US20110183356 METHOD TO IDENTIFY PATIENTS AT RISK FOR LUNG TRANSPLANT REJECTION  
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one...
7981667 Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto  
An alloyed semiconductor quantum dot comprising an alloy of at least two semiconductors, wherein the quantum dot has a homogeneous composition and is characterized by a band gap energy that is...
US20110166062 GIP-BASED MIXED AGONISTS FOR TREATMENT OF METABOLIC DISORDERS AND OBESITY  
Glucagon peptides that exhibit GIP agonist activity in addition to glucagon and/or GLP-I activity are provided. Pharmaceutical compositions comprising such glucagon peptides and therapeutic methods...
7968345 Permethylation of oligosaccharides  
A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides,...
US20110143386 METHOD FOR THE ANALYSIS OF O-LINKED OLIOSACHARIDES  
A method of analyzing O-linked oligosaccharides in a sample is disclosed. The method comprises the steps of digesting a glycoprotein with a proteolytic enzyme, performing solid-phase permethylation...
US20110142846 METHOD FOR DIAGNOSING AND TREATING EMPHYSEMA  
The present invention provides methods for diagnosing a patient with emphysema or COPD by detecting the levels of EMAP II in a sample. Alternatively, methods are provided for determining the...
7961330 Sub-micron surface plasmon resonance sensor systems  
A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements...
7961329 Sub-micron surface plasmon resonance sensor systems  
A sensor for detecting the presence of a target analyte, ligand or molecule in a test fluid, comprising a light transmissive substrate on which an array of surface plasmon resonant (SPR) elements...
7939281 Method to identify patients at risk for lung transplant rejection  
Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one...
US20110098217 COMPOUNDS EXHIBITING GLUCAGON ANTAGONIST AND GLP-1 AGONIST ACTIVITY  
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of...
US20110098188 BLOOD BIOMARKERS FOR PSYCHOSIS  
A plurality of biomarkers determine the diagnosis of psychosis based on the expression levels in a sample such as blood. Subsets of biomarkers predict the diagnosis of delusion or hallucination....
7932023 csPCNA isoform modifications and uses thereof  
Methods and compositions to detect the presence of csPCNA isoform by identifying one or more posttranslational modifications are disclosed. Methods to identify csPCNA isoform through...
US20110065633 ESTER-BASED PEPTIDE PRODRUGS  
Prodrug formulations of bioactive polypeptides are provided wherein the bioactive polypeptide has been modified by the linkage of a dipeptide to the bioactive polypeptide through an ester linkage....
US20110057389 FINANCIAL BOARD GAME  
A financial board game for use with a targeted population subset, typically including at least one child, is disclosed. The board game includes a board indicating at least one path including a...
7893408 Methods and apparatus for ionization and desorption using a glow discharge  
A method for ionizing and desorbing a sample for analysis includes energizing a first and second electrode to produce a glow discharge at atmospheric pressure. The method further includes supplying...
US20110015386 PERMETHYLATION OF OLIGOSACCHARIDES  
A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides,...
US20100331246 ESTER-BASED INSULIN PRODRUGS  
Prodrug formulations of bioactive polypeptides are provided wherein the bioactive polypeptide has been modified by the linkage of a dipeptide to the bioactive polypeptide through an ester linkage....
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