Patents and Patent Applications from Indiana University ARTI


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US20170349642 GLUCAGON/GLP-1 RECEPTOR CO-AGONISTS  
Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.
US20170344706 SYSTEMS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF NEUROLOGICAL DISORDERS  
Systems and methods for data compression which facilitate the diagnosis and treatment of neurodevelopmental and neurodegenerative disorders. The methods comprise performing the following...
US20170340716 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND ASTHMA  
The present invention provides compounds and methods for treating or preventing pulmonary diseases include COPD and asthma. In particular, the present invention provides for compounds comprising...
9827357 Cavopulmonary viscous impeller assist device and method  
A bearingless and sealless rotary blood pump is disclosed which provides multidirectional flow intended to provide low-pressure, high-volume right-sided partial assist circulatory support in a...
US20170338567 MULTIBAND WAVELENGTH SELECTIVE STRUCTURE  
A wavelength selective structure for selectively reflecting or absorbing incident electromagnetic visible or infrared radiation. The wavelength selective structure includes a wavelength selective...
US20170337327 UNIFIED COMPUTATIONAL METHOD AND SYSTEM FOR PATIENT-SPECIFIC HEMODYNAMICS  
A method for computing patient-specific hemodynamics. The method includes receiving three dimensional imaging data of a patent, extracting anatomical data from the three dimensional imaging data,...
US20170333712 SYSTEM AND METHOD FOR NON-INVASIVELY CONTROLLING AUTONOMIC NERVE ACTIVITY USING SKIN  
System and methods for monitoring and/or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subject's...
US20170328910 PRO-ANGIOGENIC AND ANTI-ANGIOGENIC HEMATOPOIETIC PROGENITOR CELL POPULATIONS  
Methods for identifying active angiogenesis and vasculopathy are described. More particularly, the present disclosure relates to cellular biomarkers, and to methods of screening cellular...
9816102 Compositions and systems for conferring disease resistance in plants and methods of use thereof  
Compositions, systems and methods are provided for conferring disease resistance to plant pathogens that use proteases to target plant substrate proteins inside plant cells. Briefly, the...
US20170321220 PRESENTATION OF BIOACTIVE PROTEINS  
The invention provides a fusion protein comprising an antigen binding domain linked to a bacteriophage decoration (Dec) protein along with a polynucleotide comprising the nucleic acid sequence of...
9810664 Ion mobility spectrometer and method of operating same  
In a linear drift tube partitioned into a plurality of cascaded drift tube segments each followed by an ion elimination region, a system and method of separating ions includes repeatedly...
US20170313755 INSULIN RECEPTOR PARTIAL AGONISTS  
Disclosed herein are insulin analog conjugates comprising an insulin agonist covalently linked to an insulin antagonist peptide. The conjugates are high potency insulin agonists but with decreased...
US20170313652 Poly-Cyanostilbene Macrocycles  
The present disclosure concerns synthesis and anion binding features of poly-cyanostilbene macrocycles of Formula (I):
US20170311579 TRIPLE TRANSGENIC PIGS SUITABLE FOR XENOGRAFT  
The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are...
9803826 Method for folding flat, non-rigid materials to create rigid, three-dimensional structures  
The present disclosure provides a cover for a light source and a method for making a cover for a light source.
US20170307636 BIOMARKER FOR DETERMINING MITOCHONDRIAL DAMAGE IN FRIEDREICH'S ATAXIA  
Compositions and methods for screening for a disease or a disorder associated with a deficiency in frataxin in a subject using biomarkers for diseases or disorders associated with a deficiency in...
US20170307565 HYBRID ION MOBILITY SPECTROMETER  
A hybrid ion mobility spectrometer includes a single-pass drift tube having an ion inlet and an ion outlet, a multiple-pass drift tube having an ion inlet and an ion outlet each coupled to the...
US20170304462 ARTIFICIAL ANTIGEN-PRESENTING CELLS AND METHODS FOR PRODUCING AND USING THE SAME  
Described herein are biomimetic Janus particles useful as artificial antigen presenting cells capable of activating T cells in vitro. “Bull's eye” ligand patterns mimicking either the native or...
US20170304362 MATERIALS AND METHODS TO ENHANCE HEMATOPOIETIC STEM CELLS ENGRAFTMENT PROCEDURES  
This disclosure is directed to the methods of enhancing hematopoietic stem cells (HSPC) and progenitor cell (HSPC) engraftment procedure. Treatment in vivo of a HSPC donor with compounds that...
US20170304222 Compounds, Compositions and Methods for Treating Oxidative DNA Damage Disorders  
Compounds, compositions, and formulations, and accompanying methods useful for treating disorders arising from oxidative DNA damage, including oxidative DNA damage resulting from ionizing...
9796722 Hepatitis B viral assembly effectors  
Novel virus assembly effector compounds having a therapeutic effect against Hepatitis B viral infection are disclosed. Assembly effector molecules described herein can lead to defective viral...
US20170298426 SYSTEMS AND METHODS FOR LOCALIZED SURFACE PLASMON RESONANCE BIOSENSING  
Biosensors and methods for localized surface plasmon resonance biosensing are disclosed. The biosensor can include a substrate having a substrate surface to which a plurality of localized surface...
US20170296713 ATRAUMATIC SELECTIVE SURGICAL SUCTION DEVICE AND METHOD  
Suction devices are disclosed comprising a side wall defining a lumen, an open proximal end sized to provide coupling to a suction source, a distal wall opposite the open proximal end, the distal...
US20170296300 DEVICE AND METHOD FOR VIBRATION OF AN IMPLANTABLE DEVICE  
Devices for imparting vibration to implanted devices to reduce accumulation of biofilm thereon including a vibration tip, the vibration tip being sized and shaped to couple to a vibrator and...
9790263 GIP receptor-active glucagon compounds  
Glucagon peptides with increased GIP activity are provided, optionally with GLP-1 and/or glucagon activity. In some embodiments, C-terminally extended glucagon peptides comprising an amino acid...
9783592 Glucagon superfamily peptides exhibiting nuclear hormone receptor activity  
Provided herein are glucagon superfamily peptides conjugated with NHR ligands that are capable of acting at a nuclear hormone receptor. Also provided herein are pharmaceutical compositions and...
9782491 Peptide conjugates for treating pain  
Described herein are compounds, composition, and methods for treating pain. In particular, described herein compounds, compositions, and methods that modulate the protein-protein-interaction...
US20170283479 LIPIDATED AMIDE-BASED INSULIN PRODRUGS  
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed...
US20170281788 INCRETIN-INSULIN CONJUGATES  
Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor,...
9775854 Materials and methods for treating diseases caused by genetic disorders using aminoglycosides and derivatives thereof which exhibit low nephrotoxicity  
Various aspects related to the preparation of congeners of the aminoglycosides gentamicin such as the congener C2 and using this compound or derivatives thereof and pharmaceutically active salts...
US20170279401 ULTRA WIDE SPECTRUM PHOTOVOLTAIC-THERMOELECTRIC SOLAR CELL  
The present invention is a photovoltaic-thermoelectric solar cell and a method of manufacturing a photovoltaic-thermoelectric solar cell. The solar cell includes a substantially transparent...
US20170273609 METHOD AND APPARATUS FOR ASSESSING TISSUE OXYGENATION SATURATION  
A method and apparatus for assessing tissue oxygenation saturation during physical activity comprising the steps of providing at least one near-infrared spectroscopy probe including at least one...
9770423 Modulation sAPP, sAAP α and BDNF levels in individuals diagnosed with FXS and ASD  
A method of treating and monitoring patient diagnosed with Autistic Spectrum disorder or Fragile X syndrome comprising measuring plasma biomarker levels of BDNF, sAPP, and sAPP alpha and adjusting...
US20170267704 SALICYLIC ACID DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, COMPOSITION THEREOF AND METHOD OF USE THEREOF  
The present invention relates to novel compounds, compositions containing same and methods for inhibiting STAT3 and/or STAT5 activity or for the treatment of a STAT3 or STAT5-dependent cancer...
US20170266253 ANTITHETICAL REGULATION OF ENDOTHELIAL ACE AND ACE2 BY BRG1-FOXM1 COMPLEX UNDERLIES PATHOLOGICAL CARDIAC HYPERTROPHY  
Methods are disclosed herein for administering a FoxM1 inhibitor for preventing, treating, and/or reducing cardiac hypertrophy and/or cardiac failure. Particularly, the methods are directed to the...
US20170266197 METHODS AND COMPOSITIONS FOR TREATING HEPATITIS B VIRUS INFECTIONS  
Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.
9767580 Apparatuses, methods, and systems for 2-dimensional and 3-dimensional rendering and display of plenoptic images  
Apparatuses, methods and systems for processing, rendering and displaying plenoptic images are disclosed. One exemplary embodiment is a method comprising storing a plenoptic image in a...
US20170261518 BIOMARKERS AND ASSAY TO DETECT CHRONIC GRAFT VERSUS HOST DISEASE  
A four-biomarker panel for diagnosis of chronic graft-versus-host disease (cGVHD) and methods of prognosing and/or diagnosing cGVHD using the biomarker panel are disclosed.
9758562 Glucagon/GLP-1 receptor co-agonists  
Provided herein are peptides and variant peptides that exhibit enhanced activity at the GLP-1 receptor, as compared to native glucagon.
9757350 Small molecule inhibitors of replication protein A that also act synergistically with cisplatin  
Replication protein A (RPA) is a single-strand DNA-binding protein with essential roles in DNA replication, recombination and repair. Small molecule inhibitors (SMIs) with the ability to disrupt...
US20170251646 TRANSGENIC PIGS LACKING ONE OR MORE CELLULAR TRANSPORT GENES  
The application provides methods of improving a medication related side effect in a human after transplant of transgenic organs, tissues or cells from transgenic pigs with a disrupted cellular...
US20170251629 METHOD AND APPARATUS FOR SPATIAL COGNITIVE ASSESSMENT OF A LAB ANIMAL  
The present disclosure relates to a method and apparatus for performing a cognitive bias assay on a lab animal. The apparatus may include a first base member and a second base member spaced apart...
9751835 Processes and intermediates for preparing indole pharmaceuticals  
The invention described herein pertains to processes and intermediates for preparing indole containing pharmaceuticals, particularly to processes and intermediates for preparing selective estrogen...
9750481 System and method for analyzing antegrade and retrograde blood flow  
A computer-implemented method for simultaneously analyzing antegrade and retrograde blood flow is provided. The method is implemented using a computing device including a processor in...
US20170248612 METHODS FOR DETECTING SINUSOIDAL OBSTRUCTIVE SYNDROME (SOS)  
Disclosed are biomarker panels for evaluating subjects at risk of sinusoidal obstruction syndrome (SOS) early after hematopoietic stem cell transplantation (HSCT). In particular, the present...
9745288 Compounds and methods for treating cancer by inhibiting the urokinase receptor  
Compounds and methods for treating or preventing cancer associated with binding to the urokinase receptor are provided. Biological processes affected by the compounds include cell migration, cell...
9744249 Method and apparatus for kidney function analysis  
A method and apparatus for determining physiological data related to an animal, such as kidney diagnostics data, is provided. The method includes injecting a mixture of a first and a second...
US20170240858 METHODS FOR GENREATING THE INNER EAR AND OTHER CRANIAL PLACODE-DERIVED TISSUES USING PLURIPOTENT STEM CELLS  
Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells...
US20170239225 COMBINATION THERAPIES FOR TREATMENT OF SPINAL MUSCULAR ATROPHY  
Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron...
US20170231548 SYSTEM AND METHOD FOR BLADDER TRANSDUCER PLACEMENT  
A tissue sensing device and a method for placing the device. The device including a first electrically conductive needle; a non-conductive sheath receiving the first needle therein and allowing...