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US20120035531 |
ON-DEMAND AND REVERSIBLE DRUG RELEASE BY EXTERNAL CUE
The invention provides a method to release drugs from a polymer matrix upon demand without degrading the matrix. By applying ultrasound to a self-healable polymer matrix in physiological...
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US20120033823 |
NANO-OTOLOGIC PROTECTIVE EQUIPMENT FOR IMPACT NOISE TOXICITY AND/OR BLAST OVERPRESSURE EXPOSURE
An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent...
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US20120033697 |
WAVELENGTH BEAM COMBINING OF QUANTUM CASCADE LASER ARRAYS
A laser source based on a quantum cascade laser array (QCL), wherein the outputs of at least two elements in the array are collimated and overlapped in the far field using an external diffraction...
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US20120031830 |
Transporting and Treating Water
Water can be transported and/or treated using a system or container in which a collapsible framework is attached to a membrane. A collapsible water container defining a volume for receiving,...
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US20120029416 |
POROUS ELECTROACTIVE HYDROGELS AND USES THEREOF
The present invention provides porous electroactive hydrogels, the deformation angle of which is controlled by electroactuation, and methods for preparing and using such hydrogels.
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US20120029199 |
SYNTHESIS OF ENONE INTERMEDIATE
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary...
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US20120029065 |
COMPOSITIONS FOR TREATING OR PREVENTING OBESITY AND INSULIN RESISTANCE DISORDERS
Provided herein are methods and compositions for modulating the activity or level of a sirtuin, thereby treating or preventing obesity or an insulin resistance disorder, such as diabetes in a...
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US20120028837 |
RAPID SCREEN FOR REPRODUCTIVE TOXICANTS
Disclosed herein are methods to assess the biological safety of an agent. The method involves contacting one or more test agents to a culture of C. elegans and analyzing the culture for meiotic...
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US20120028478 |
VAPOR DEPOSITION OF METAL OXIDES, SILICATES AND PHOSPHATES, AND SILICON DIOXIDE
Metal silicates or phosphates are deposited on a heated substrate by the reaction of vapors of alkoxysilanols or alkylphosphates along with reactive metal amides, alkyls or alkoxides. For example,...
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US20120028290 |
Compositions and Methods for Labeling and Imaging Phospholipids
The present invention provides a method to label phospholipids in vivo based on the metabolic incorporation of an alkynyl- or azido-labeled metabolic precursor into phospholipids. The resulting...
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US20120027808 |
NICOTINE IMMUNONANOTHERAPEUTICS
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in...
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US20120024364 |
SILICON-BASED VISIBLE AND NEAR-INFRARED OPTOELECTRIC DEVICES
In one aspect, the present invention provides a silicon photodetector having a surface layer that is doped with sulfur inclusions with an average concentration in a range of about 0.5 atom percent...
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US20120022013 |
METHODS AND COMPOSITIONS FOR EXTENDING THE LIFE SPAN AND INCREASING THE STRESS RESISTANCE OF CELLS AND ORGANISMS
The invention provides methods and compositions for modulating the life span of eukaryotic and prokaryotic cells and for protecting cells against certain stresses, e.g., heatshock. One method...
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US20120021983 |
COMPOSITIONS AND METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER AND PROGRESSION, AND FOR SCREENING ANTI-CANCER AGENTS
MicroRNA (miRNA) profiling of cells showed unique miRNA signatures for each of three Akt isoforms. Among differentially regulated miRNA species, the miR-200 family was downregulated in...
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US20120021924 |
DETECTION AND MODULATION OF CYTOCHROME C ACETYLATION
The invention relates to detection and modulation of cytochrome c acetylation. The invention has diagnostic and therapeutic applications for neurodegenerative disorders and cancer.
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US20120021519 |
EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments,...
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US20120021479 |
Systems of Hydrogen Production in Bacteria
This invention relates to engineered bacterial systems such as engineered cyanobacterial systems and to methods of using these bacterial systems to generate hydrogen.
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US20120015822 |
PARTICLE-ASSISTED NUCLEIC ACID SEQUENCING
This invention generally relates to particle-assisted nucleic acid sequencing. In some embodiments, sequencing may be performed in a microfluidic device, which can offer desirable properties, for...
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US20120015382 |
DROPLET-BASED SELECTION
The present invention generally relates to fluidic droplets, and techniques for screening or sorting such fluidic droplets. In some embodiments, the fluidic droplets may contain cells (e.g.,...
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US20120010178 |
METHODS AND COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS
Methods, compounds and compositions for promoting motor neuron survival and the treatment of a neurodegenerative disorders such as Spinal Muscular Atrophy (SMA) are described herein.
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US20120009589 |
SUB-DIFFRACTION IMAGE RESOLUTION AND OTHER IMAGING TECHNIQUES
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from two...
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US20120009504 |
ELECTRODES FOR FUEL CELLS
A method comprises creating an electrode by depositing alternating first and second layers on a substrate, and using the electrode to make a solid oxide fuel cell. The first layer comprises a...
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8093262 |
Use of huperzine for disorders
Methods and compositions containing huperzine are used to prevent and alleviate neuropathic pain. The invention is also directed to methods and compositions for using huperzine for the prevention...
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8093009 |
Mass spectrometric methods and products
The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
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8092697 |
Molecular characterization with carbon nanotube control
In a method for fabricating a molecule characterization device, there is formed an aperture in a support structure, and electrical contact pads are formed on a selected surface of the support...
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US20120003754 |
METHODS, PRODUCTS AND TREATMENTS FOR DIABETES
The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also...
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US20120001284 |
SILICON NITRIDE LIGHT PIPES FOR IMAGE SENSORS
Various embodiments for etching of silicon nitride (SixNy) lightpipes, waveguides and pillars, fabricating photodiode elements, and integration of the silicon nitride elements with photodiode...
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8088951 |
Epigenetic mechanisms re-establish access to long-term memory after neuronal loss
The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.
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8088816 |
3-3-di-substituted-oxindoles as inhibitors of translation initiation
Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl) -3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for...
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US20110319493 |
HISTONE DEACETYLASES, AND USES RELATED THERETO
The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in...
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US20110319352 |
Compounds That Bind Oxysterol Binding Proteins, and Methods of Use Thereof
The invention relates in part to the discovery that certain CRAMs, such as schweinfurthin A, target OSBPs (a family of oxysterol binding proteins). Because OSBPs have been shown to be integral to...
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US20110319286 |
SYSTEM FOR SCREENING AGONISTS/ANTAGONISTS OF CELLULAR SIGNALING PATHWAYS
The present invention identifies a method for investigating the response of a cell membrane-associated protein in a living cell to a drug by labeling the protein with a visual marker, and also...
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US20110318424 |
METHODS FOR PROLONGING VIABILITY OF CONE CELLS USING MODULATORS OF THE MAMMALIAN TARGET OF RAPAMYCINE (mTOR)
The present invention is directed to the use of modulators of the mammalian target of rapamycine (mTOR) pathway, glucose and/or glucose enhancers for treating retinal disorders and, in particular,...
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US20110318267 |
PH-RESPONSIVE NANOSTRUCTURES
The present invention relates to compositions comprising stimuli-responsive materials which can be used for delivery of agents. Materials are provided that can respond to changes in a surrounding...
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US20110315962 |
NANOSENSORS
Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be...
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US20110315898 |
Plasmonic Polarizer
A radiation-emitting device (e.g., a laser) includes an active region configured to generate a radiation emission linearly polarized along a first polarization direction and a device facet covered...
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8084596 |
Regulated apoptosis
We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to...
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8084205 |
Genetic risk assessment technology for epithelial cancer involving gene-environment interaction between ERCC5 and tobacco use
Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are...
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US20110313045 |
HISTONE DEACETYLASES, AND USES RELATED THERETO
The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in...
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US20110312507 |
REACTION DISCOVERY SYSTEM
A novel reaction discovery system that does not depend on DNA duplex formation is provided. The advantages of this system include exploring reactions conditions not possible where DNA hybridization...
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US20110312080 |
POROUS FILMS BY A TEMPLATING CO-ASSEMBLY PROCESS
A method of making a composite includes providing a particle suspension comprising colloidal particles (430) and a soluble matrix precursor (440); and co-depositing the particles and the matrix...
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US20110310915 |
METHODS AND APPARATUS FOR SINGLE-MODE SELECTION IN QUANTUM CASCADE LASERS
Methods and apparatus for improved single-mode selection in a quantum cascade laser. In one example, a distributed feedback grating incorporates both index-coupling and loss-coupling components....
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US20110309265 |
DIAMOND NANOWIRES
In a general aspect, a system includes a plurality of diamond nanowires disposed on the surface of a diamond substrate, at least some of the nanowires including a color center. The system also...
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US20110309237 |
LIGHT ABSORPTION AND FILTERING PROPERTIES OF VERTICALLY ORIENTED SEMICONDUCTOR NANO WIRES
A nanowire array is described herein. The nanowire array comprises a substrate and a plurality of nanowires extending essentially vertically from the substrate; wherein: each of the nanowires has...
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US20110309233 |
SELECTED SPECTRAL ABSORPTION OF NANOWIRES
Methods, apparatuses, systems, and devices relating to fabricating one or more nanowires are disclosed. One method for fabricating a nanowire includes: selecting a particular wavelength of...
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8080467 |
Silicon-based visible and near-infrared optoelectric devices
In one aspect, the present invention provides a silicon photodetector having a surface layer that is doped with sulfur inclusions with an average concentration in a range of about 0.5 atom percent...
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8080394 |
Method for determining predisposition to pulmonary infection
Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection...
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8080203 |
Air sterilization apparatus
An air sterilization apparatus for sterilizing air that can include a fan assembly, which may be mounted in an upper-part of a room, and a UVC lamp to emit a UVGI field. The air sterilization...
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US20110305761 |
POLYMERSOMES, COLLOIDOSOMES, LIPOSOMES, AND OTHER SPECIES ASSOCIATED WITH FLUIDIC DROPLETS
The present invention relates generally to vesicles such as liposomes, colloidosomes, and polymersomes, as well as techniques for making and using such vesicles. In some cases, the vesicles may be...
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US20110305670 |
NUCLEIC ACID ENCODING FUSION POLYPEPTIDES THAT PREVENT OR INHIBIT HIV INFECTION
The present invention is directed to an isolated nucleic acid molecule encoding a fusion polypeptide the expression of which in cells is capable of blocking the entry of HIV-1 into host cells and...
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