Patents and Patent Applications from Harvard University


Match Document Document Title
US20180265922 SYSTEMS AND METHODS FOR EPIGENETIC SEQUENCING  
The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA...
US20180265898 CARBON FIXATION SYSTEMS AND METHODS  
Systems and methods for fixing carbon using bacteria are described. In one embodiment, a system includes a reactor chamber with a solution contained therein. The solution may include hydrogen...
US20180265589 GLYCATED CD59 PEPTIDES, THEIR PREPARATION, AND USES THEREOF  
The present invention provides glycated Amadori products of the CD59 peptide and fragments thereof to be used as tools and among methods for the diagnosis and prognosis of pre-diabetes and...
US20180265519 TRICYCLIC PROTEASOME ACTIVITY ENHANCING COMPOUNDS  
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of...
US20180265507 HOST TARGETED INHIBITORS OF DENGUE VIRUS AND OTHER VIRUSES  
Novel antiviral compounds of Formulae (I)-(III) are provided: The inventive compounds, pharmaceutical compositions thereof, and kits including the inventive compounds are useful for the prevention...
US20180265183 Aerodynamic Devices for Enhancing Lift and Reducing Drag  
An aerodynamic device for enhancing lift and reducing drag on a body, comprising a plurality of raised members, each having a symmetric profile and including a central portion having an elongated...
US20180264775 Negative Poisson's Ratio Waffle Structures  
In at least some aspects, an auxetic structure includes a first sheet defining therein a plurality of a plurality of structural elements projecting from the first sheet, the plurality of...
US20180264774 Hybrid Dimple-And-Void Auxetic Structures With Engineered Patterns For Customized NPR Behavior  
Auxetic structures, low porosity auxetic sheets, systems and devices with auxetic structures, and methods of using and methods of making auxetic structures are disclosed. An auxetic structure is...
US20180263970 COMPOUNDS AND METHODS USEFUL FOR TREATING OR PREVENTING HEMATOLOGICAL CANCERS  
The present invention includes methods of treating patients with acute myeloid leukemia across a range of genetic subtypes with DHODH inhibitors, such as...
US20180263676 TOOL FOR USE WITH A FASTENER  
A tool for use with a fastener, more particularly, a medical screwdriver tool arranged to interact with a fastener has a driver body with a driver shaft, the driver shaft being associated with a...
10077463 Optical selection of cells  
Provided herein are photochemical crosslinkers and photocleavable crosslinkers and their uses in methods for cell selection from cell cultures. The photochemical crosslinkers comprise a...
10077453 CAS9 proteins including ligand-dependent inteins  
Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of...
US20180259700 BROADBAND DISPERSION-COMPENSATED AND CHIRAL META-HOLOGRAMS  
A device includes a substrate and at least one transmissive directional diffractive component disposed on the substrate. The device has high efficiency transmission over a broadband portion of the...
US20180259541 Small Molecule Biosensors  
Biosensors for small molecules can be used in applications that range from metabolic engineering to orthogonal control of transcription. Biosensors are produced based on a ligand-binding domain...
US20180258488 METHODS OF DETECTING DISEASES OR CONDITIONS USING PHAGOCYTIC CELLS  
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to...
US20180258435 BIOSYNTHETIC AMYLOID-BASED MATERIALS DISPLAYING FUNCTIONAL PROTEIN SEQUENCES  
Embodiments of the present disclosure are directed to methods of genetically modifying bacteria to create amyloid-based materials, such as biofilms created by amyloid fibers, having nonnative...
US20180257076 ACOUSTIC WAVE SORTING  
The present invention generally relates to the manipulation of species using acoustic waves such as surface acoustic waves. In some aspects, a channel such as a microfluidic channel may be...
10074054 Systems and methods for Bayesian optimization using non-linear mapping of input  
Techniques for use in connection with performing optimization using an objective function that maps elements in a first domain to values in a range. The techniques include using at least one...
10073035 Sub-diffraction limit image resolution and other imaging techniques  
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques. In one aspect, the invention is directed to determining and/or imaging light from...
10071350 Microfluidic active mixing nozzle for three-dimensional printing of viscoelastic inks  
The present disclosure relates to a device for three-dimensional ink deposition from an impeller-driven active mixing microfluidic printing nozzle. The device is configured to receive a material...
US20180254117 ELECTRICALLY CONDUCTIVE NANOSTRUCTURES  
A structure includes a high-strength nanowire core with a first electrically-conductive metal layer bonded to an outer surface thereof. An insulating layer is bonded to an outer surface of the...
US20180252844 WAVELENGTH SELECTIVE OPTICAL NANOSTRUCTURES FABRICATED ON THE SURFACE OF BULK HOMOGENOUS SUBSTRATES  
An optical structure having enhanced optical properties, the optical structure comprising a bulk homogenous FIG. 1A substrate that is surface modified so as to provide the enhanced optical...
US20180251833 Method and Apparatus for Volumetric Imaging of a Three-Dimensional Nucleic Acid Containing Matrix  
Methods of volumetric imaging of a three-dimensional matrix of nucleic acids within a cell is provided. An automated apparatus for sequencing and volumetric imaging of a three-dimensional matrix...
US20180251818 EARLY DEVELOPMENTAL GENOMIC ASSAY FOR CHARACTERIZING PLURIPOTENT STEM CELL UTILITY AND SAFETY  
The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for...
US20180251740 COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN  
Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these...
US20180251649 HYDROGEL COMPOSITE INK FORMULATION AND METHOD OF 4D PRINTING A HYDROGEL COMPOSITE STRUCTURE  
A method of 4D printing comprises depositing a layer of filaments in a predetermined arrangement on a flexible substrate. Each filament comprises a hydrogel matrix and a plurality of anisotropic...
10065989 Molecular sleds and uses thereof  
The present invention relates to compositions which may comprise a molecular sled linked to cargo and uses thereof. In particular, the present invention relates to a non-naturally occurring or...
US20180246318 METHODS AND APPARATUS FOR MODULATING LIGHT USING A DEFORMABLE SOFT DIELECTRIC  
Methods and apparatus for modulating light thorough a transparent laminate structure. The transparent laminate structure includes at least one soft dielectric layer and at least one stiff...
US20180246143 NANOSCALE SCANNING SENSORS  
A sensing probe may be formed of a diamond material comprising one or more spin defects that are configured to emit fluorescent light and are located no more than 50 nm from a sensing surface of...
US20180244858 Hydrogels with Improved Mechanical Properties Below Water Freezing Temperature  
Hydrogel compositions, and corresponding methods of making, are provided. The hydrogels do not freeze, or only partially freeze, over a wide range of temperatures below the freezing temperature of...
US20180244731 COMPOSITIONS AND METHODS FOR TREATMENT OF PAIN  
Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these...
US20180243231 Injectable Cryogel Vaccine Devices and Methods of Use Thereof  
The invention provides polymer compositions for cell and drug delivery.
10062011 Systems and methods for machine learning enhanced by human measurements  
In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function...
10059990 In situ nucleic acid sequencing of expanded biological samples  
The invention provides in situ nucleic acid sequencing to be conducted in biological specimens that have been physically expanded. The invention leverages the techniques for expansion microscopy...
10059657 Class-and isoform-specific HDAC inhibitors and uses thereof  
HDAC inhibitors of the general formula (I) and (II) and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and...
10058647 Biomimetic actuation device and system, and methods for controlling a biomimetic actuation device and system  
A biomimetic actuation device includes a flexible substrate, conformable for disposition about an object, defining an apex and a base, bearing at least one soft actuator configured to change state...
US20180239950 NON-LINEAR IMAGING SYSTEMS AND METHODS FOR ASSISTED REPRODUCTIVE TECHNOLOGIES  
The present invention generally relates to non-linear imaging systems and methods for use in various assisted reproductive technologies and other applications. In one aspect, the present invention...
US20180239070 MODIFYING OPTICAL PROPERTIES OF THIN FILM STRUCTURES USING AN ABSORBING ELEMENT  
A method of making a multi-layered film includes depositing thin film layers onto a first side of a double-sided transparent substrate. The thin film layers are transparent, and two adjacent...
US20180237787 GENE EDITING OF PCSK9  
Provided herein are systems, compositions, and methods of introducing loss-of-function mutations in to protein factors involved in the LDL-R-mediated cholesterol clearance pathway, e.g., PCSK9,...
US20180237758 EVOLUTION OF TALENS  
Engineered transcriptional activator-like effectors (TALEs) are versatile tools for genome manipulation with applications in research and clinical contexts. One current drawback of TALEs is that...
US20180237392 CHARGED ION CHANNEL BLOCKERS AND METHODS FOR USE  
The invention provides compounds, compositions, methods, and kits for the treatment of pain, itch, and neurogenic inflammation.
US20180236081 DELIVERY OF NEGATIVELY CHARGED PROTEINS USING CATIONIC LIPIDS  
Compositions, methods, strategies, kits, and systems for the delivery of negatively charged proteins, protein complexes, and fusion proteins, using cationic polymers or lipids are provided....
10053725 In situ interaction determination  
Methods, reagents, compositions, and kits for in situ interaction determination (ISID) via interaction-dependent polymerase chain reaction (ID-PCR) are provided herein. ISID technology is useful...
10053445 Photocleavable chemical inducers of dimerization (CID) and methods of use  
The instant invention provides photolysable compounds, and their use in reversible chemical induced dimerization and light-induced regulation of proteins.
US20180230533 Spatial Sequencing of Nucleic Acids Using DNA Origami Probes  
A method of sequencing nucleic acids is provided using DNA origami as a barcode for a nucleic acid probe.
US20180230450 Cas9 Genome Editing and Transcriptional Regulation  
CRISPR/Cas Systems are provided where two or more guide RNAs having different spacer sequence lengths direct an enzymatically active Cas9 having a transcriptional regulator attached thereto to...
US20180230428 Compositions and Methods for Modulating an Immune Response  
The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those...
US20180230164 CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS  
The present invention provides unified synthesis of the CI-CI 9 building blocks of halichondrins and analogs theoreof using selective coupling of poly-halogenated nucleophiles in chromium-mediated...
US20180230111 SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF  
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary...
10049871 Anisotropic deposition in nanoscale wires  
The present invention generally relates to nanoscale wires, including anisotropic deposition in nanoscale wires. In one set of embodiments, material may be deposited on certain portions of a...