Patents and Patent Applications from Harvard University


Match Document Document Title
US20180172672 DEVICES COMPRISING MUSCLE THIN FILMS AND USES THEREOF IN HIGH THROUGHPUT ASSAYS FOR DETERMINING CONTRACTILE FUNCTION  
The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for use in these assays.
US20180171373 ASSAYS AND OTHER REACTIONS INVOLVING DROPLETS  
The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments,...
US20180171361 Multiplexed Genome Editing  
A method of modulating some or all copies of a gene in a cell is provided including introducing into a cell one or more ribonucleic acid (RNA) sequences that comprise a portion that is...
US20180169403 NANOWIRE ARRAYS FOR NEUROTECHNOLOGY AND OTHER APPLICATIONS  
The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g.,...
10001149 Manufacturing soft devices out of sheet materials  
A soft composite actuator is described, including a first elastomeric layer; a strain limiting layer; and a first radially constraining layer, wherein the first elastomeric layer is disposed...
10000756 Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics  
The invention provides compositions and methods for regulating microRNA (miRNA) biogenesis. The invention also relates to compositions and methods for treating or preventing cancer in a subject in...
9999671 Delivery of negatively charged proteins using cationic lipids  
Compositions, methods, strategies, kits, and systems for the delivery of negatively charged proteins, protein complexes, and fusion proteins, using cationic polymers or lipids are provided....
US20180164298 IMMUNE CELL TRAPPING DEVICES AND METHODS FOR MAKING AND USING THE SAME  
Embodiments herein described provide devices for identifying and collecting rare cells or cells which occur at low frequency in the body of a subject, such as, antigen-specific cells or...
US20180164290 NMR-BASED METABOLITE SCREENING PLATFORM  
Methods that enable one to specifically measure the metabolic product of a particular molecule in relatively few cells, e.g. primary cells, are described. The methods involve optionally preloading...
US20180162862 INHIBITORS OF BACTERIAL GLYCOSYL TRANSFERASES  
Described herein are compounds of Formula (I′), Formula (IA), Formulae (I)-(VII), pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers,...
US20180161256 PROCESS FOR STIMULATING HYALURONIC ACID SYNTHESIS  
Compositions allowing the stimulation of hyaluronic acid synthesis via an increase in has-2 expression and their use in the treatment of conditions related to a decrease in hyaluronic acid synthesis.
9996778 Methods of storing information using nucleic acids  
The present invention relates to methods of storing data using one or more nucleic acids.
9994582 Cortistatin analogues and syntheses and uses thereof  
Provided herein are compounds of Formula (A), (B), (C), (D) and (E), pharmaceutically acceptable salts, quaternary amine salts, and N-oxides thereof, and pharmaceutical compositions thereof....
9993921 Flexible and stretchable electronic strain-limited layer for soft actuators  
A soft robot having an integrated electrical component includes an expandable or collapsible body, the body comprising an inlet that is configured to communicate with a fluid source and a flexible...
US20180160099 SUB-DIFFRACTION LIMIT IMAGE RESOLUTION IN THREE DIMENSIONS  
The present invention generally relates to sub-diffraction limit image resolution and other imaging techniques, including imaging in three dimensions. In one aspect, the invention is directed to...
US20180155778 SYSTEMS AND METHODS FOR EPIGENETIC SEQUENCING  
The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA...
US20180155777 SYSTEMS AND METHODS FOR EPIGENETIC SEQUENCING  
The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA...
US20180155716 NOVEL CRISPR ENZYMES AND SYSTEMS  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems...
US20180155708 Split Cas9 Proteins  
Split Cas9 proteins, including an active nuclease, a nickase, and a nuclease-null Cas9 protein, are provided. The Cas9 proteins were derived from nucleic acids encoding the S. pyogenes Cas9...
US20180155430 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20180155427 ANTIBODY MOLECULES TO PD-1 AND USES THEREOF  
Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
US20180155361 PALLADIUM-MEDIATED KETOLIZATION  
Provided herein are palladium-mediated coupling reactions useful in the preparation of ketone-containing organic molecules. The provided methods can be used for the preparation of natural products...
US20180153941 METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND USES THEREOF  
Disclosed herein are methods for generating SC-β cells, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
US20180153902 SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION  
The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing...
9992867 Cellulose and cellulosic substrate-based device  
A cellulosic substrate-based device is described, including a cellulosic substrate comprising a functionalized surface covalently functionalized by a chemical moiety in an amount sufficient to...
9988617 Engineered heme-binding compositions and uses thereof  
Described herein are heme-binding compositions and methods relating to their use, e.g. methods of treatment of, for example, sepsis and rhabdomyolysis.
9988452 Antibody molecules to PD-L1 and uses thereof  
Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The anti-PD-L1 antibody molecules can be...
US20180151361 N-TYPE DOPING OF STRAINED EPITAXIAL GERMANIUM FILMS THROUGH CO-IMPLANTATION AND NANOSECOND PULSED LASER MELTING  
In one aspect a method of fabricating an n-doped strained germanium (Ge) film is disclosed, which includes depositing a strained Ge film on an underlying substrate, implanting at least one...
US20180148715 High-Throughput Single Cell Barcoding  
Methods and compositions for high-throughput, single cell analyses are provided. The methods and compositions can be used for analysis of genomes and transcriptomes, as well as antibody discovery,...
US20180147273 METHODS FOR DISPLAYING POLYPEPTIDES AND USES THEREOF  
Provided herein are methods and compositions for displaying a polypeptide on a tubular structure and uses of such displayed polypeptides in the production of antibodies or vaccines.
9984278 Non-linear imaging systems and methods for assisted reproductive technologies  
The present invention generally relates to non-linear imaging systems and methods for use in various assisted reproductive technologies and other applications. In one aspect, the present invention...
9982005 Macrolides and methods of their preparation and use  
Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides, including both known and novel macrolides....
9981981 Tricyclic proteasome activity enhancing compounds  
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of...
9981377 Flexible robotic actuators  
Systems and methods for providing flexible robotic actuators are disclosed. Some embodiments of the disclosed subject matter include a soft robot capable of providing a radial deflection motions;...
US20180143091 ARTIFICIAL SKIN AND ELASTIC STRAIN SENSOR  
An elastic strain sensor can be incorporated into an artificial skin that can sense flexing by the underlying support structure of the skin to detect and track motion of the support structure. The...
US20180142198 DELIVERY OF BIOMOLECULES TO IMMUNE CELLS  
A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell...
US20180142108 FOAM INK COMPOSITION AND 3D PRINTED HIERARCHICAL POROUS STRUCTURE  
A foam ink composition for printing porous structures comprises stabilizing particles and gas bubbles dispersed in a solvent. The stabilizing particles comprise a predetermined interfacial energy...
US20180141992 CELLS LACKING B2M SURFACE EXPRESSION AND METHODS FOR ALLOGENEIC ADMINISTRATION OF SUCH CELLS  
Disclosed herein are cells and populations of cells comprising a genome in which the B2M gene has been edited to eliminate surface expression of MHC Class I protein in the cells or population of...
9975916 Compositions and methods relating to complex nucleic acid nanostructures  
The invention provides SST motifs of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The motifs are formed, at least in part, by the...
US20180138047 System and Method for Wafer-Scale Fabrication of Free Standing Mechanical and Photonic Structures By Ion Beam Etching  
A method for fabrication of free standing mechanical and photonic structures is presented. A resist mask is applied to a bulk substrate. The bulk substrate is attached to a movable platform. The...
US20180135134 TARGETED SELECTION OF PATIENTS FOR TREATMENT WITH CORTISTATIN DERIVATIVES  
A method for the targeted selection and treatment of patients with a tumor or cancer, comprising (i) determining whether the patient has a RUNX1 pathway impairment; and if so (ii) administering an...
US20180135095 ANTIBACTERIAL POLYPEPTIDE LIBRARIES AND METHODS FOR SCREENING THE SAME  
Compositions and methods for isolating polypeptides having antibiotic activity are provided. In some aspects, bacterial cell populations are provided that express a surface-displayed library of...
US20180134725 CORTISTATIN ANALOGUES, SYNTHESES, AND USES THEREOF  
New cortistatin compounds and pharmaceutically acceptable salts and pharmaceutically acceptable compositions thereof are provided. These compounds can be used to treat a disorder mediated by CDK8...
US20180133670 MICROFLUIDIC ACTIVE MIXING NOZZLE FOR THREE-DIMENSIONAL PRINTING OF VISCOELASTIC INKS  
The present disclosure relates to a device for three-dimensional ink deposition from an impeller-driven active mixing microfluidic printing nozzle. The device is configured to receive a material...
9972795 Organic light-emitting diode materials  
Described herein are molecules for use in organic light emitting diodes. Example molecules comprise at least one moiety A and at least one moiety D. Values and preferred values of the moieties A...
9971228 Direct entangled triplet-photon sources and methods for their design and fabrication  
In one aspect, a device for generating triplet photons is disclosed, which includes a waveguide extending from a proximal end for receiving pump radiation to a distal end through which triplet...
9970024 RNA-guided human genome engineering  
A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the...
US20180130940 Driver for a High Voltage Capacitive Actuator  
A driver for a circuit with a capacitive load, is disclosed, including an input stage, a bi-directional power converter, and a controller to control the driver. The power converter includes an...
US20180129775 Control Approach To Cell Reprogramming  
A method is presented for reprogramming cells of a subject. As a starting point, a biological sample of a sample cell is received from the subject, where the sample cell has a given cell type. The...
US20180127823 METHOD FOR DETERMINATION AND IDENTIFICATION OF CELL SIGNATURES AND CELL MARKERS  
The present invention provides for methods of identifying cell types and cell subtypes from a biological sample or population of target cells. The methods further provide for determining cell type...