Patents and Patent Applications from Harvard University


Match Document Document Title
10478112 Enhancing diagnosis of disorder through artificial intelligence and mobile health technologies without compromising accuracy  
A computer system for generating a diagnostic tool by applying artificial intelligence to an instrument for diagnosis of a disorder, such as autism. For autism, the instrument can be a...
US20190346658 OPTICAL DEVICES INCLUDING ROTARY VARIABLE OPTICAL ELEMENTS  
A collection of optical sub-elements can be arranged sequentially, such that they share a common optical axis through which light propagates. Each of these optical sub-elements can alter a phase,...
US20190346442 IMPROVED HLA EPITOPE PREDICTION  
Adaptive immune responses rely on the ability of cytotoxic T cells to identify and eliminate cells displaying disease-specific antigens on human leukocyte antigen (HLA) class I molecules....
US20190345518 NOVEL CRISPR ENZYMES AND SYSTEMS  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems...
US20190345483 AAV Split Cas9 Genome Editing and Transcriptional Regulation  
The invention provides methods of altering a target nucleic acid in a cell using the AAV split Cas9 platform. The methods comprise providing the cell an enzymatically active Cas9 and optionally a...
US20190345224 Gene Therapy Methods for Age-Related Diseases and Conditions  
Methods of gene therapy are provided for treating or preventing age-related diseases or conditions by regulating one or more functional proteins associated with age-related diseases or conditions.
US20190345193 NUCLEIC ACID NANOSWITCH CONSTRUCTION METHODS  
This disclosure provides methods for generating functionalized nanoswitches, as well as the functionalized nanoswitches themselves, and methods of use thereof.
US20190345116 SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF  
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary...
US20190344237 Compositions Comprising Encapsulated Actives within Droplets and other Compartments  
The present invention generally relates to microparticles and, in particular, to systems and methods for encapsulation within microparticles. In one aspect, the present invention is generally...
US20190343979 PREFABRICATED ALGINATE-DRUG BANDAGES  
The invention provides a solution to the drawbacks associated with conventional alginate dressings. This invention features improved alginate dressings or bandages as well as a fabrication process...
US20190343842 USES OF SALT-INDUCIBLE KINASE (SIK) INHIBITORS  
The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as...
US20190343190 MATERIALS INCLUDING POLYMERIC FIBERS INCORPORATING MICROCAPSULES OR NANOCAPSULES INCLUDING AN ESSENTIAL OIL  
The present disclosure provides materials and articles of clothing including a plurality of nanocapsules, each nanocapsule including a polymeric shell surrounding at least one fluid, and a...
10472612 Cell culture system  
The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or...
10471016 Microparticles, methods for their preparation and use  
The invention relates to microparticles comprising a crosslinked gel and methods for making and using same.
10470987 Process for stimulating hyaluronic acid synthesis  
Compositions allowing the stimulation of hyaluronic acid synthesis via an increase in has-2 expression and their use in the treatment of conditions related to a decrease in hyaluronic acid synthesis.
US20190340948 CLUSTER ANALYSIS OF PARTICIPANT RESPONSES FOR TEST GENERATION OR TEACHING  
Textual responses to open-ended (i.e., free-response) items provided by participants (e.g., by means of mobile wireless devices) are automatically classified, enabling an instructor to assess the...
US20190338250 METHODS FOR GENERATING STEM CELL-DERIVED BETA CELLS AND METHODS OF USE THEREOF  
Disclosed herein are methods for generating SC-β cells, and isolated populations of SC-β cells for use in various applications, such as cell therapy.
10465723 Soft robotic actuators  
A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the...
10465176 Cas variants for gene editing  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the...
10465158 Systems and methods for cell culture device interconnection and fluidic device interconnection  
Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at...
10464031 Microfluidic active mixing nozzle for three-dimensional printing of viscoelastic inks  
A microfluidic printing nozzle for 3D printing may include a mixing chamber, a first inlet for connecting with a first ink source, the first inlet located at a first end of the mixing chamber, and...
US20190330706 NUCLEIC ACID AMPLIFICATION ASSAYS FOR DETECTION OF PATHOGENS  
The present invention relates to a method for generating primers and/or probes for use in analyzing a sample which may comprise a pathogen target sequence comprising providing a set of input...
US20190330617 Methods of Generating Libraries of Nucleic Acid Sequences for Detection via Fluorescent in Situ Sequ  
The present disclosure provides a number of targeted nucleic acid FISSEQ library construction methods. Targeted FISSEQ can exhibit several benefits, such as enhanced sensitivity and/or shorter...
US20190330350 ANTI-PD-L1 MONOCLONAL ANTIBODIES AND FRAGMENTS THEREOF  
The present invention is based, in part, on the discovery of monoclonal antibodies that specifically bind to the cytoplasmic domain of PD-L1 antibodies useful for diagnostic, prognostic, and...
10462907 Printed three-dimensional (3D) functional part and method of making  
A printed 3D functional part includes a 3D structure comprising a structural material, and at least one functional electronic device is at least partially embedded in the 3D structure. The...
10460220 Methods of storing information using nucleic acids  
The present invention relates to methods of storing data using one or more nucleic acids.
10457977 Particle-assisted nucleic acid sequencing  
This invention generally relates to particle-assisted nucleic acid sequencing. In some embodiments, sequencing may be performed in a microfluidic device, which can offer desirable properties, for...
10457733 Agents that modulate immune cell activation and methods of use thereof  
The present invention relates to compositions and methods for the immunomodulation mediated by the interaction of PD-L2 and RGMb.
10457715 Optogenetic probes for measuring membrane potential  
Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the...
US20190323061 HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBES  
The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
US20190323050 Modulation of Enzymatic Polynucleotide Synthesis Using Chelated Divalent Cations  
Methods and apparatus of modulating polynucleotide synthesis are provided. The methods include delivering reagents comprising enzymes, nucleotides and ions to oligonucleotide primers wherein the...
US20190322992 CAS VARIANTS FOR GENE EDITING  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the...
US20190321791 APPARATUS AND METHOD FOR FORMING EMULSIONS  
An apparatus for creating an emulsion, including: an inlet chamber; a channel comprising a length L, height H, an inlet and an outlet, and walls having surface energies, the channel inlet adjacent...
US20190321443 Modulators of MS4A activity  
Provided herein are methods of treating Alzheimer's disease, atopy, allergies, asthma, and a disease or disorder associated with neuroinflammation by modulating MS4A receptors. Also found herein...
US20190321417 BACTERIAL PROBIOTIC TO DETOXIFY HERBICIDES AND INSECTICIDES  
Described herein are methods and compositions for the use of detoxifying an herbicide and/or promoting resistance to an herbicide. Aspects of the invention relate to administering to a subject in...
10450467 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Sanitation systems and components thereof having a slippery surface
 
The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces. Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid,...
US20190317085 COMPARTMENTALISED SCREENING BY MICROFLUIDIC CONTROL  
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a)...
US20190316151 ENGINEERED VIRAL VECTOR REDUCES INDUCTION OF INFLAMMATORY AND IMMUNE RESPONSES  
Modified viral genomes are able to reduce induction of inflammatory and immune anti-viral responses. This manifests itself in reduced NF-kB activity, increased viral transduction rates, and...
US20190315799 SCALABLE PRODUCTION OF GENETICALLY ENGINEERED NANOFIBROUS MACROSCOPIC MATERIALS VIA FILTRATION  
Provided herein are filtration-based purification methods for amyloid fibers, such as curli fibers, directly from microbial culture, and their fabrication into free-standing thin films....
US20190314395 USE OF COMPOUNDS ACTIVATING SIRT-3 FOR MIMICKING EXERCISE  
The invention relates to modulation of SIRT3 activity levels. The invention has applications for regulating metabolism and mimicking caloric restriction or exercise in a muscle cell.
10443092 Methods of elongating DNA  
The present invention relates to methods of elongating chromosomes. Embodiments of the present disclosure are directed to methods of elongating DNA by immobilizing or attaching the DNA to a...
10443042 Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof  
Disclosed herein are methods for generating SC-β cells using chemically defined, completely serum free media, and isolated populations of SC-β cells for use in various applications, such as cell...
US20190310264 TECHNIQUES FOR HIGH THROUGHPUT TARGETED PROTEOMIC ANALYSIS AND RELATED SYSTEMS AND METHODS  
Described herein is a kit of materials prepared for assays that involve determining relative abundance and/or absolute abundance of various targeted peptides. The kit may comprise trigger versions...
US20190309357 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS  
The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA...
US20190309259 UNIVERSAL DONOR STEM CELLS AND RELATED METHODS  
Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in...
US20190309065 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
10438498 Instructional support platform for interactive learning environments  
In various embodiments, subject matter for improving discussions in connection with an educational resource is identified and summarized by analyzing annotations made by students assigned to a...
10436768 Density-based separation of biological analytes using mutliphase systems  
The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more...
10436747 Nanopore sensing by local electrical potential measurement  
There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic...
10436650 Nanometer scale quantum thermometer  
An approach to nanoscale thermometry that utilizes coherent manipulation of the electronic spin associated with nitrogen-vacancy (NV) color centers in diamond is disclosed. The methods and...