Patents and Patent Applications from Harvard University


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9841331 Artificial skin and elastic strain sensor  
An elastic strain sensor can be incorporated into an artificial skin that can sense flexing by the underlying support structure of the skin to detect and track motion of the support structure. The...
9840699 Methods for nucleic acid editing  
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the...
9839911 Droplet creation techniques  
The present invention is generally related to systems and methods for producing droplets. The droplets may contain varying species, e.g., for use as a library. In some cases, at least one droplet...
9839890 Compartmentalised combinatorial chemistry by microfluidic control  
The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of...
US20170352542 NANOSCALE WIRES WITH TIP-LOCALIZED JUNCTIONS  
The present invention generally relates to nanoscale wires and, in particular, to nanoscale wires with heterojunctions, such as tip-localized homo- or heterojunctions. In one aspect, the nanoscale...
US20170350885 ASSAYS FOR ANTIMICROBIAL ACTIVITY AND APPLICATIONS THEREOF  
The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
US20170349950 T CELL BALANCE GENE EXPRESSION, COMPOSITIONS OF MATTERS AND METHODS OF USE THEREOF  
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell...
9834775 Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them  
Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on...
9833978 Monolithic fabrication of three-dimensional structures  
A multi-layer, super-planar structure can be formed from distinctly patterned layers. The layers in the structure can include at least one rigid layer and at least one flexible layer; the rigid...
9833503 Methods for displaying polypeptides and uses thereof  
Provided herein are methods and compositions for displaying a polypeptide on a tubular structure and uses of such displayed polypeptides in the production of antibodies or vaccines.
US20170342109 Natural IGM Antibodies and Inhibitors Thereof  
The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.
US20170340588 MODULATION OF REGULATORY T CELLS VIA G-COUPLED PROTEIN RECEPTOR 43  
Disclosed herein are compositions and methods that are useful for inducing the development of regulatory T cells (Treg). Such compositions and methods are useful for treating inflammatory...
9829557 Use of nuclear spin impurities to suppress electronic spin fluctuations and decoherence in composite solid-state spin systems  
A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath...
9829488 Paper-based cellular arrays  
Three-dimensional cellular arrays, methods of making three-dimensional cellular arrays, and methods of identifying agents using the arrays are disclosed.
9827717 Statistical predictive modeling and compensation of geometric deviations of 3D printed products  
A non-transitory, tangible, computer-readable storage media may contain a program of instructions that causes a computer system having a processor running the program of instructions to: receive...
9827517 Electrochemical carbon nanotube filter and method  
A filtration apparatus and filtration method can be used to reduce at least one contaminant (e.g., organic molecules, ions and/or biological microorganisms) in an aqueous fluid. The filtration...
9826922 System and method for automatically discovering, characterizing, classifying and semi-automatically labeling animal behavior and quantitative phenotyping of behaviors in animals  
A method for studying the behavior of an animal in an experimental area including stimulating the animal using a stimulus device; collecting data from the animal using a data collection device;...
US20170337342 METHOD AND APPARATUS FOR USING GAIT ANALYSIS TO DETERMINE A HEALTH QUALITY MEASURE  
A method, computer-readable storage device and apparatus for calculating a health quality measure are disclosed. For example, a method receives characteristics of motion information, wherein the...
US20170337324 Methods for Retrievable Information Storage Using Nucleic Acids  
A method of storing information using monomers such as nucleotides is provided including converting a format of information into a plurality of bit sequences of a bit stream with each having a...
US20170337323 Methods of Making Polypeptides with Non-Standard Amino Acids Using Genomically Recoded Organisms  
A method of making a polypeptide including at least one covalent bond between a pair of reactive side chains of corresponding amino acids, wherein the covalent bond is insensitive to reduction is...
US20170333941 HIGH ENERGY EFFICIENCY PHASE CHANGE DEVICE USING CONVEX SURFACE FEATURES  
Sub-micrometer to centimeter scale rough symmetric and asymmetric structures are incorporated onto objects (e.g. tubes and fms). Asymmetric and hierarchically structured slippery structures can be...
US20170333914 MAGNETIC CAPTURE OF A TARGET FROM A FLUID  
Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided....
US20170333895 MATRIX-ASSISTED SPECTROPHOTOMETRY  
Disclosed herein are multiwell plates suitable for spectrophotometry for low-volume liquid samples. For the multiwell plates, the bottom of at least one well has a layer of porous matrix disposed...
9826622 Reducing noise and temperature during measurements in cryostats  
A device is disclosed to reduce noise and temperature during measurements in cryostats comprising, the device comprising any of, or a combination of, the following PC boards, each conditioning a...
9822370 Method of making a deletion in a target sequence in isolated primary cells using Cas9 and two guide RNAs  
Disclosed herein are methods, compositions, and kits for high efficiency, site-specific genomic editing of cells.
9821045 Controlled delivery of TLR3 agonists in structural polymeric devices  
The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and...
US20170329086 Apparatus for Coupling to High-Index Micro-Resonators with Tapered Optical Fibers  
Tapered waveguides made of high-index material attached to a tapered optical fiber are provided, enabling access to the optical modes of large, high-index resonators. In some embodiments, an...
US20170327888 TRIGGERED ASSEMBLY OF METAFLUOROPHORES  
Aspects of the present disclosure relate to systems, kits and methods that comprise a nucleic acid capture strand linked to a first dye molecule, a nucleic acid trigger strand longer than the...
US20170327781 ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF  
An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply...
US20170326254 Efficient delivery of therapeutic molecules in vitro and in vivo  
A chimeric molecule of one or more proteins or peptides fused, complexed or linked to one or more anionic molecules. Efficient in vitro and in vivo delivery is attained by encapsulating these...
9816121 Assays and other reactions involving droplets  
The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments,...
9816080 Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)  
Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems,...
9815898 Antibody molecules to PD-1 and uses thereof  
Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
9815871 Genetic reprogramming of bacterial biofilms  
Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to...
9815082 Surface wetting method  
In a method for forming nanopores, two opposing surfaces of a membrane are exposed to an electrically conducting liquid environment. A nanopore nucleation voltage pulse, having a first nucleation...
US20170322196 Multiphase Systems and Uses Thereof  
A multi-phase system includes a phase-separated solution comprising at least two phases, each phase having a phase component selected from the group consisting of a polymer, a surfactant and...
US20170321284 CLONAL HAEMATOPOIESIS  
The present invention relates to clonal expansion of somatic cells in subjects, and acquired selective advantage of cell clones during the lifetime of a subject. In particular, the invention...
US20170321198 NOVEL CRISPR ENZYMES AND SYSTEMS  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems...
US20170321177 ACOUSTIC WAVES IN MICROFLUIDICS  
Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one set of embodiments, droplets may be sorted using...
US20170320928 ALPHA/BETA-POLYPEPTIDE ANALOGS OF GLUCAGON-LIKE PEPTIDE 1  
Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than native GLP-1. In the analogs, at least...
US20170320886 CORTISTATIN ANALOGUES AND SYNTHESES THEREOF  
The present invention relates to analogs of cortistatin A, J, K, and L, having the general formula: and salts thereof, wherein R1, R2, R3, R4, n, and m are as defined herein; processes for...
US20170319517 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITIS  
The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is...
US20170319443 MULTIPLE EMULSIONS COMPRISING RIGIDIFIED PORTIONS  
The present invention generally relates to microfluidic droplets and, in particular, to multiple emulsion microfluidic droplets. In one set of embodiments, multiple emulsion droplets are provided,...
9808326 3D dentofacial system and method  
A reference standard or reference system for dental feature location and orientation can include evaluating the facial appearance of one or more subjects based on aesthetic criteria and selecting...
US20170314538 FLEXIBLE THIN ROBOTIC ACTUATORS  
Some embodiments of the disclosed subject matter includes a laminated robotic actuator. The laminated robotic actuator includes a strain-limiting layer comprising a flexible, non-extensible...
US20170313767 METHODS OF DIAGNOSIS AND TREATMENT OF TUBERCULOSIS AND INFECTION  
Described herein are methods of treating, diagnosing, and/or prognosing a disease in a subject relating to detection of the glycosylation state of the antibodies present in the subject. In some...
US20170313757 OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL  
Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the...
9804239 Nuclear singlet states as a contrast mechanism for NMR spectroscopy  
Methods and systems for Nuclear Magnetic Resonance (NMR) spectra of complex chemical mixtures are described. The methods and systems allow undesired NMR spectral background to be removed or...
US20170306335 RNA-TARGETING SYSTEM  
The invention provides for systems, methods, and compositions for targeting RNA. In particular, the invention provides a non-naturally occurring or engineered RNA-targeting system comprising an...
US20170306307 CRISPR HAVING OR ASSOCIATED WITH DESTABILIZATION DOMAINS  
The disclosure includes non-naturally occurring or engineered CRISPR Cas9, each associated with at least one destabilization domain (DD), along with compositions, systems and complexes involving...