Patents and Patent Applications from Harvard University


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US20180048011 HIGH pH ORGANIC FLOW BATTERY  
Provided herein are redox flow (e.g., rechargeable) batteries having a first aqueous electrolyte including a first type of redox active material (e.g., a quinone or alloxazine) and a second...
US20180045889 METHOD AND SYSTEM FOR POLARIZATION STATE GENERATION  
An apparatus for polarization state generation and phase control includes a Stokes Basis generator to generate multiple Stokes Bases from one or more input beams, an intensity modulator to...
US20180044372 SINGLE-STRANDED DNA NANOSTRUCTURES  
The present disclosure relates to nanostructures assembled from nucleic acid consisting of a single strand of DNA rationally-designed to self-assemble into a hairpin loop, helical domains, and...
US20180042718 ARTIFICIAL TYMPANIC MEMBRANE DEVICES AND USES  
This disclosure features artificial tympanic membrane graft devices and two-component bilayer graft devices that include a scaffold having a plurality of ribs made of a first material and a...
9891297 Magnetic sensing and imaging using interactions between surface electron spins and solid state spins  
Systems and methods for magnetic sensing and imaging include a sensor having a network of isolated electron-spin quantum bits (qubits) disposed on the surface of the sensor; and a solid state...
US20180036454 SCAFFOLDS FOR CELL COLLECTION OR ELIMINATION  
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that...
9885041 Modulation of BCL11A for treatment of hemoglobinopathies  
The invention relates to methods and uses of modulating fetal hemoglobin expression (HbF) in a hematopoietic progenitor cells via inhibitors of BCL11A expression or activity, such as RNAi and...
9885016 Compositions and methods for modulating an immune response  
The invention provides methods of modulating follicular regulatory T (TFR) cell-mediated immune responses, follicular helper T (TFH) cell-mediated immune responses or both, and the use of those...
9884830 Synthesis of tetracyclines and analogues thereof  
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary...
US20180031572 OPTOGENETIC PROBES FOR MEASURING MEMBRANE POTENTIAL  
The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using...
US20180031553 SYSTEMS, METHODS, AND WORKFLOWS FOR OPTOGENETICS ANALYSIS  
The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity....
US20180031010 SOFT ACTUATORS AND SOFT ACTUATING DEVICES  
A soft buckling linear actuator is described, including: a plurality of substantially parallel bucklable, elastic structural components each having its longest dimension along a first axis; and a...
US20180030533 Single Cell Nucleic Acid Detection and Analysis  
Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
US20180030515 Droplet-Based Method And Apparatus For Composite Single-Cell Nucleic Acid Analysis  
The present invention generally relates to a combination of molecular barcoding and emulsion-based microfluidics to isolate, lyse, barcode, and prepare nucleic acids from individual cells in a...
US20180030409 METHODS OF GENERATING FUNCTIONAL HUMAN TISSUE  
Methods of tissue engineering, and more particularly methods and compositions for generating various vascularized 3D tissues, such as 3D vascularized embryoid bodies and organoids are described....
9880356 Apparatus for coupling to high-index micro-resonators with tapered optical fibers  
Tapered waveguides made of high-index material attached to a tapered optical fiber are provided, enabling access to the optical modes of large, high-index resonators. In some embodiments, an...
9879078 Method of treating lipodystrophy in HIV-infected humans  
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of...
9879003 Host targeted inhibitors of dengue virus and other viruses  
Novel antiviral compounds of Formulae (I)-(III) are provided: (I) (II) (III) The inventive compounds, pharmaceutical compositions thereof, and kits including the inventive compounds are useful for...
9878536 Acoustophoretic printing apparatus and method  
The present invention contains a printing apparatus and a method, e.g., for ejecting inks (i.e. pure liquids, mixtures, colloids, etc.) for a very broad range of physical properties (such as...
9878325 Electronic control of fluidic species  
Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and...
9878299 Methods for encapsulation of actives within droplets and other compartments  
The present invention generally relates to microparticles and, in particular, to systems and methods for encapsulation within microparticles. In one aspect, the present invention is generally...
9877981 NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation  
Disclosed herein are novel compositions and methods for the treatment of age-related diseases, mitochondrial diseases, the improvement of stress resistance, the improvement of resistance to...
US20180024110 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITIY OF LIVING TISSUE LAYERS  
Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid...
US20180023728 FLUID-BASED GATING MECHANISM WITH TUNABLE MULTIPHASE SELECTIVITY AND ANTIFOULING BEHAVIOR  
A gating mechanism that uses a capillary stabilized liquid as a reversible, reconfigurable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined pore in the...
US20180023133 SYSTEMS AND METHODS FOR EPIGENETIC SEQUENCING  
The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the DNA...
US20180023109 ASSAY AND OTHER REACTIONS INVOLVING DROPLETS  
The present invention generally relates to droplets and/or emulsions, such as multiple emulsions. In some cases, the droplets and/or emulsions may be used in assays, and in certain embodiments,...
US20180021780 SYSTEM AND METHOD FOR A BIOMIMETIC FLUID PROCESSING  
A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally...
US20180021253 PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY  
The invention provides methods and compositions for reducing tumor-mediated immune evasion and inducing patient-specific immunization.
9872905 Modulation of NK cell antigen specific effector activity by modulation of CXCR6 (CD186)  
The instant invention is based, at least in part, on the discovery that CXCR6 plays a critical role in antigen-specific effector function of NK cells. Accordingly, the invention provides, among...
US20180019668 Device and Method for Hybrid Feedback Control of a Switch-Capacitor Multi-Unit Voltage Regulator  
A device and method for hybrid feedback control of a switch-capacitor multi-unit voltage regulator are presented. A multi-unit switched-capacitor (SC) core includes a plurality of SC converter...
US20180018479 AUTOMATED SYSTEM AND METHOD FOR CONSTRUCTING CARD MULTIPACKS, AND CARD MULTIPACK CONSTRUCTED USING THE SAME  
Automated systems, methods for constructing card multipacks, and a card multipack constructing using the same are provided. An automated system for constructing card multipacks includes: a movable...
US20180016622 SYSTEMS, METHODS, AND KITS FOR AMPLIFYING OR CLONING WITHIN DROPLETS  
The present invention generally relates to droplet-based microfluidic devices, including systems, methods, and kits for amplifying or cloning within droplets. In some embodiments, the present...
US20180012106 SYSTEMS AND METHODS FOR MACHINE LEARNING ENHANCED BY HUMAN MEASUREMENTS  
In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function...
US20180010174 MICROSCOPE-FREE IMAGING  
Provided herein, in some aspects, are methods of imaging molecules without a microscope or other specialized equipment, referred to herein as “microscope-free imaging (MFI).” Herein, “molecular...
US20180010149 PLASMONIC NANOCAVITY-BASED CELL THERAPY METHOD AND SYSTEM  
In one aspect, a structure for use in transfecting cells is disclosed, which comprises a matrix supporting a plurality of cavities, each cavity having an opening characterized by a rim and an...
US20180009847 PROLINE-LOCKED STAPLED PEPTIDES AND USES THEREOF  
The present invention provides a new type of alpha-helix nucleating cross-link (“staple”) formed by olefin metathesis of a proline derivative with an alkenyl side chain and another amino acid...
US20180009257 Zero-Porosity NPR Structure And Tuning Of NPR Structure For Particular Localities  
The present concepts include a zero-porosity structure having a plurality of structural elements arranged to provide a negative Poisson's ratio and, further, a new mechanism to generate negative...
US20180008980 FLUIDIC DEVICE FOR QUANTIFYING THE DYNAMIC PERMEABILITY AND HYDRAULIC CONDUCTIVITIY OF LIVING TISSUE LAYERS  
Systems and methods for measuring dynamic hydraulic conductivity and permeability associated with a cell layer are disclosed. Some systems include a microfluidic device, one or more working-fluid...
US20180008502 Soft Exosuit for Assistance with Human Motion  
Systems and methods for providing assistance with human motion, including hip and ankle motion, are disclosed. Sensor feedback is used to determine an appropriate profile for actuating a wearable...
US20180008093 SYSTEMS AND METHODS FOR AN AUTOMATED BARBECUE SMOKER  
Devices, systems, and computer-readable medium are provided for a barbecue smoker device. A barbecue smoker device is provided, that includes a multi-wall container, a food platform, a heat...
9864953 Systems and methods for Bayesian optimization using integrated acquisition functions  
Techniques for use in connection with performing optimization using an objective function. The techniques include using at least one computer hardware processor to perform: identifying, using an...
US20180003696 GENE EDITING THROUGH MICROFLUIDIC DELIVERY  
Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. The methods...
US20180003200 PNEUMATIC INSECT ROBOTS  
A modular pneumatic robotic actuator, including a first elongated hollow structure and a second elongated hollow structure connected to each other at a moveable joint; an inflatable bladder...
US20180002754 FRIZZLED 2 AS A TARGET FOR THERAPEUTIC ANTIBODIES IN THE TREATMENT OF CANCER  
Disclosed herein are methods of treating cancer in a subject, and methods for inhibiting growth, migration and/or invasion of a cancer cell in the subject, comprising administering to the subject...
US20180002662 PURIFICATION OF GERM STEM CELLS BY TARGETING MRP9  
Provided herein are methods and compositions for the purification and detection of germ stem cells (e.g., oogonial stem cells) based on expression of MRP9.
9858529 Systems and methods for multi-task Bayesian optimization  
Techniques for use in connection with performing optimization using a plurality of objective functions associated with a respective plurality of tasks. The techniques include using at least one...
9857374 Biomarkers for the early detection of breast cancer  
The present invention provides reagents and methods for breast cancer detection.
9857356 Muscle chips and methods of use thereof  
The present invention provides high throughput assays for identifying compounds that modulate a contractile function, as well as devices suitable for these assays.
9857353 Kit for density-based separation of biological analytes using multiphase systems  
A kit for separating a sample comprising one or more biological analytes of interest using a multi-phase system comprising: a) two or more phase components selected from the group consisting of a...
9857315 Fourier transform microwave spectroscopy for enantiomer-specific detection of chiral molecules  
A spectrometer includes: (1) a housing defining a volume into which an analyte gas is introduced, the analyte gas including a chiral component; (2) a microwave generator coupled to the housing and...