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US20120129759 |
PROTEIN SURFACE REMODELING
Aggregation is a major cause of the misbehavior of proteins. A system for modifying a protein to create a more stable variant is provided. The method involves identifying non-conserved hydrophobic...
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US20120127568 |
METHODS AND APPARATUS FOR SCANNING MICROSCOPY USING ONE OR MORE FRESNEL ZONE PLATES
Microscopy methods and apparatus in which one or more microfabricated optical elements (e.g., one or more Fresnel zone plates) operate as one or an array of objective lenses. A single object or a...
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8183178 |
Iterated branching reaction pathways via nucleic acid-mediated chemistry
The present invention provides methods and compositions for performing multi-step nucleic acid mediated synthesis of a highly diverse collection of molecules, for example, small molecules and...
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US20120122889 |
SMALL MOLECULE INHIBITORS OF NECROPTOSIS
The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by ...
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US20120122218 |
Harnessing Cell Dynamics to Engineer Materials
The invention features synthetic materials and methods for inducing cell behavior. Matrix materials induce cell differentiation and cell manipulation based on mechanical and physical...
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US20120121539 |
Programming Of Cells for Tolerogenic Therapies
Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation....
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US20120121481 |
SCALE-UP OF FLOW-FOCUSING MICROFLUIDIC DEVICES
Parallel uses of microfluidic methods and devices for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid are described. In some aspects, the present invention...
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US20120119738 |
METHODS AND APPARATUS FOR SAMPLE TEMPERATURE CONTROL IN NMR SPECTROMETERS
Described are methods and apparatus, referred to as “temperature-lock,” which can control and stabilize the sample temperature in an NMR spectrometer, in some instances with a precision and an acc...
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8180717 |
System for estimating a distribution of message content categories in source data
A method of computerized content analysis that gives “approximately unbiased and statistically consistent estimates” of a distribution of elements of structured, unstructured, and partially str...
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8178907 |
Nanoscopic wire-based electrical crossbar memory-devices and arrays
Electrical devices comprised of nanoscopic wires are described, along with methods of their manufacture and use. The nanoscopic wires can be nanotubes, preferably single-walled carbon nanotubes....
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8178579 |
Dioxanes and uses thereof
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I): and...
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8178316 |
Evaluating proteins
The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence...
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US20120115948 |
INHIBITORS OF ANAPHASE PROMOTING COMPLEX ACTIVITY
The invention provides an anti-proliferative composition comprising a non-peptide analog of the C-terminal isoleucine-arginine (IR) tail motif of an activator of an anaphase promoting complex...
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US20120115915 |
N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION
Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative...
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US20120115818 |
SYNTHESIS OF TETRACYCLINES AND INTERMEDIATES THERETO
Efficient method for preparing the enone intermediate (VII) used in the synthesis of tetracyclines derivatives. In particular, the invention provides a synthesis which allows for substituents at...
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US20120109563 |
METHOD AND APPARATUS FOR QUANTIFYING A BEST MATCH BETWEEN SERIES OF TIME UNCERTAIN MEASUREMENTS
The best match of two time-uncertain series is quantified with a degree of confidence by selecting one of the time series and repeatedly computing a maximum covariance between the selected time...
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US20120108605 |
O-GLCNAC TRANSFERASE INHIBITORS AND USES THEREOF
The present invention provides inhibitors of O-GIcNAc transferase. Typically, the inhibitors are quinolinone-6-sulfonamides. The invention also provides pharmaceutical compositions thereof and...
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US20120108075 |
Gas-Phase Functionalization of Surfaces of Microelectronic Structures
There are provided methods for functionalizing a planar surface of a microelectronic structure, by exposing the surface to at least one vapor including at least one functionalization species, such...
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US20120107601 |
SYSTEMS AND METHODS OF TEMPLATING USING PARTICLES SUCH AS COLLOIDAL PARTICLES
The present invention generally relates to systems and methods for using particle templating, e.g., to produce composites, discrete particles, or the like. In some embodiments, the present...
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8168159 |
Compounds for tumor diagnosis and therapy
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is...
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US20120094862 |
CLASS II HUMAN HISTONE DEACETYLASES, AND USES RELATED THERETO
The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II...
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US20120094382 |
MOLECULAR DELIVERY WITH NANOWIRES
A molecular delivery system including a plurality of nanowires (e.g., Si NWs), each of the nanowires having a surface layer formed of a silicon-containing material and a covalently bound linker...
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US20120089030 |
SYSTEM AND METHOD FOR CHARACTERIZATION OF ORAL, SYSTEMIC AND MUCOSAL TISSUE UTILIZING RAMAN SPECTROSCOPY
A method and system for characterizing tissue includes a probe connected to a red LASER source and a Raman spectroscope. The probe includes at least excitation fiber and one or more emission fibers...
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US20120088300 |
COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF DEFINITIVE ENDODERM
Certain embodiments disclosed herein are directed to a method of producing endoderm cells, such as definitive endoderm cells by exposing stem cells such as embryonic stem cells or induced...
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US20120088251 |
MASS SPECTROMETRIC METHODS AND PRODUCTS
The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
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US20120087973 |
siRNA MICROBICIDES FOR PREVENTING AND TREATING DISEASES
The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in...
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8154354 |
Nonlinear pulse oscillator methods and apparatus
Methods and apparatus for implementing stable self-starting and self-sustaining high-speed electrical nonlinear pulse (e.g., soliton, cnoidal wave, or quasi-soliton) oscillators. Chip-scale...
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8154002 |
Nanoscale wire-based data storage
The present invention generally relates to nanotechnology and submicroelectronic devices that can be used in circuitry and, in some cases, to nanoscale wires and other nanostructures able to encode...
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8153470 |
Doped elongated semiconductors, growing such semiconductors, devices including such semiconductors, and fabricating such devices
A method for selectively aligning and positioning semiconductor nanowires on a substrate by providing a substrate; patterning electrodes on a surface of the substrate; conditioning the surface of...
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8153432 |
Multiplex automated genome engineering
The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.
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US20120080360 |
MANIPULATION OF PARTICLES IN CHANNELS
Systems and methods for the manipulation of particles within channels such as microfluidic channels are provided. In one set of embodiments, magnets are positioned around a channel. As a fluid...
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US20120077759 |
3-3-Di-Substituted-Oxindoles as Inhibitors of Translation Initiation
Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol
-2-one and/or its derivatives are provided. Compositions, methods and kits for...
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US20120077705 |
Methods for Identifying Autophagy Inducing Compounds
This invention pertains to screening methods for identifying autophagy inducing compounds.
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US20120076805 |
Methods and Compositions for the Generation and Maintenance of Regulatory T Cells
Methods and compositions for generating and maintaining induced regulatory T cells (iTregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection,...
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8143686 |
Laser-induced structuring of substrate surfaces
In one aspect, the present invention provides a method of processing a substrate, e.g., a semiconductor substrate, by irradiating a surface of the substrate (or at least a portion of the surface)...
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8143300 |
Inhibitors of cellular necrosis
The present invention relates to compounds and pharmaceutical preparations and their use in therapy for preventing or treating trauma, ischemia, stroke and degenerative diseases associated with...
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US20120064111 |
ATTENUATED VACCINES FOR NON-SEGMENTED NEGATIVE SENSE RNA VIRUSES
The invention relates to an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene wherein the mutation reduces viral replication, the methods of...
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US20120058521 |
ENZYMATIC OLIGONUCLEOTIDE PRE-ADENYLATION
Methods and compositions for making and using pre-adenylated oligonucleotide sequences are provided.
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US20120058486 |
GENETIC RISK ASSESSMENT TECHNOLOGY FOR EPITHELIAL CANCER INVOLVING GENE-ENVIRONMENT INTERACTION BETWEEN ERCC5 AND TOBACCO USE
Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are...
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US20120058133 |
INHIBITION OF TRNA SYNTHETASES AND THERAPEUTIC APPLICATIONS THEREOF
The present invention provides novel methods for modulating Th 17-mediated immune responses using aminoacyl tRNA synthetase inhibitors. Inhibition of aminoacyl tRNA synthetase inhibitors activates...
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US20120053073 |
Methods for Detecting Signatures of Disease or Conditions in Bodily Fluids
This invention provides methods of using cell free bodily fluid and blood cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also relates to methods of using...
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8124743 |
Purification of a bivalently active antibody using a non-chromatographic method
The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a...
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US20120046282 |
METHODS AND COMPOUNDS FOR ANTIMICROBIAL INTERVENTION
The present invention provides Wall Teichoic Acid biosynthesis inhibitors such as compound 1835F03 (targocil) and related synthetic analogs. The invention also provides pharmaceutical compositions...
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8119032 |
Gas-phase functionalization of surfaces including carbon-based surfaces
The invention provides methods functionalizing a planar surface of a graphene layer, a graphite surface, or microelectronic structure. The graphene layer, graphite surface, or planar...
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US20120040846 |
Methods of Detecting Diseases or Conditions Using Phagocytic Cells
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to...
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US20120039909 |
EPIGENETIC MECHANISMS RE-ESTABLISH ACCESS TO LONG-TERM MEMORY AFTER NEURONAL LOSS
The invention relates to methods and products for enhancing and improving recovery of lost memories. In particular the methods are accomplished through the increase of histone acetylation.
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US20120039560 |
ALL-OPTICAL LOGIC GATES AND METHODS FOR THEIR FABRICATION
The present invention provides optical devices that employ nonlinear optical effects for processing optical signals. For example, such an optical device can include a nano-sized interferometric...
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US20120035531 |
ON-DEMAND AND REVERSIBLE DRUG RELEASE BY EXTERNAL CUE
The invention provides a method to release drugs from a polymer matrix upon demand without degrading the matrix. By applying ultrasound to a self-healable polymer matrix in physiological...
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US20120033823 |
NANO-OTOLOGIC PROTECTIVE EQUIPMENT FOR IMPACT NOISE TOXICITY AND/OR BLAST OVERPRESSURE EXPOSURE
An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent...
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US20120033697 |
WAVELENGTH BEAM COMBINING OF QUANTUM CASCADE LASER ARRAYS
A laser source based on a quantum cascade laser array (QCL), wherein the outputs of at least two elements in the array are collimated and overlapped in the far field using an external diffraction...
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