Patents and Patent Applications from Harvard University


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US20170299664 USE OF NUCLEAR SPIN IMPURITIES TO SUPPRESS ELECTRONIC SPIN FLUCTUATIONS AND DECOHERENCE IN COMPOSITE SOLID-STATE SPIN SYSTEMS  
A solid state electronic spin system contains electronic spins disposed within a solid state lattice and coupled to an electronic spin bath and a nuclear spin bath, where the electronic spin bath...
US20170298441 USE OF CLONAL EVOLUTION ANALYSIS FOR IBRUTINIB RESISTANCE IN CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS  
The present invention generally relates to the methods and use of clonal evolution analysis of the kinetics and genetic alterations associated with the development of resistance to a therapy using...
US20170298407 ENGINEERED WATER NANOSTRUCTURES (EWNS) AND USES THEREOF  
Various embodiments of the present invention relate to, among other things, systems for generating engineered water nanostructures (EWNS) comprising reactive oxygen species (ROS) and methods for...
US20170298402 SELF-LABELING NUCLEIC ACIDS AND METHODS OF USE  
Some aspects of this disclosure relate to the identification of reactive nucleic acids, such as, for example, reactive cellular RNAs. Minimal reactive motif consensus sequences and isolated...
US20170298344 De Novo Design of Allosteric Proteins  
Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
US20170298342 SYSTEMS AND METHODS FOR AMPLIFICATION AND PHAGE DISPLAY  
The present invention generally relates to amplification of biological entities, for example, for phage display. In one aspect, members of a library of biological entities are encapsulated in...
US20170298128 METHODS AND COMPOSITIONS FOR TREATING AGE-RELATED DISORDERS  
The present invention relates to methods and compositions containing an antagonist of a negative regulator of GDF-11 (e.g., an antibody) for use in treating an age-related condition. In particular...
9793425 Silicon-based visible and near-infrared optoelectric devices  
In one aspect, the present invention provides a silicon photodetector having a surface layer that is doped with sulfur inclusions with an average concentration in a range of about 0.5 atom percent...
9792532 Systems and methods for machine learning enhanced by human measurements  
In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function...
9791455 Optogenetic probes for measuring membrane potential  
The invention provides methods, cells and constructs for optical measurement of membrane potential. These methods can be used in cells that are not accessible to presently available methods using...
9791440 Assays for antimicrobial activity and applications thereof  
The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
9790968 Soft actuators and soft actuating devices  
A soft buckling linear actuator is described, including: a plurality of substantially parallel bucklable, elastic structural components each having its longest dimension along a first axis; and a...
9790541 Methods and compositions for labeling nucleic acids  
The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue...
9790490 CRISPR enzymes and systems  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems...
9790378 Vapor source using solutions of precursors in terpenes  
This disclosure relates to terpene solutions of metal precursors used for chemical vapor deposition, atomic layer deposition, spray pyrolysis or misted deposition. The terpenes do not supply...
9790253 OSW-1 analogs and conjugates, and uses thereof  
Provided are a number of compounds structurally related to OSW-1, a natural compound that binds OSBPs. Also provided are pharmaceutical compositions comprising the OSW-1 analogs, as well as...
9789482 Methods of introducing a fluid into droplets  
Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and...
US20170290681 Portable Prosthetic Hand With Soft Pneumatic Fingers  
A finger actuator, includes a plurality of fluidically interconnected inflatable chambers, wherein each chamber comprises outer walls having an embedded extensible layer selected to constrain...
9786850 Methods and systems for scaffolds comprising nanoelectronic components  
The present invention generally relates to nanoscale wires and tissue engineering. Systems and methods are provided in various embodiments for preparing cell scaffolds that can be used for growing...
9784804 Dynamic decoupling in solid state spin ensembles  
Long spin coherence lifetimes are realized for ensembles of electronic spin impurities in solid state spin systems, for example NV color centers in diamond, by using spin-control RF pulse...
9784648 Methods, apparatuses and systems for collection of tissue sections  
Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth...
9783678 High density membrane protein membranes  
Embodiments of the invention provide methods for preparing high density membrane protein membranes by slow, controlled removal of detergent from mixtures of detergent, block copolymers and...
9782417 Methods of increasing satellite cell proliferation with kinase inhibitors  
The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing...
US20170283831 PROTECTED GUIDE RNAS (PGRNAS)  
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of...
US20170283471 MODIFIED MICROBIAL TOXIN RECEPTOR FOR DELIVERING AGENTS INTO CELLS  
We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell...
US20170282133 IN VITRO EVOLUTION IN MICROFLUIDIC SYSTEMS  
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into...
9777262 Mutants of Cre recombinase  
The present invention relates to mutants of Cre recombinase.
9775915 Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof  
Provided herein are trioxacarcin-antibody drug conjugates of Formula (A): and pharmaceutically acceptable salts thereof, comprising at least one instance of the group -L1-(A-L2)a-B attached...
US20170276929 Pop-Up Laminate Structure Including Miniature Optical Components  
A pop-up laminate structure includes rigid layers, at least one flexible layer, at least one optical component, and an actuator. At least one of the rigid layers defines gaps extending there...
US20170275623 CANCER TREATMENT AND IMMUNE SYSTEM REGULATION THROUGH FAT10 PATHWAY INHIBITION  
Described herein are methods of inhibiting mitosis, treating cancer and/or treating immune disorders through the use of agents that inhibit FAT10 and/or the FAT10 pathway.
US20170273930 METHODS TO TREAT NEURODEGENERATIVE DISEASES  
The specification provides compositions and methods to treat neurodegenerative diseases.
9772284 Biomedical and chemical sensing with nanobeam photonic crystal cavities using optical bistability  
A miniature optical biosensor and biosensor array where high sensitivity for detection of biomolecular interaction does not require a fluorescent label. Non-linear frequency-shifts of optical...
9771574 Apparatus for continuous directed evolution of proteins and nucleic acids  
Aspects of the disclosure relate to an apparatus for continuous directed evolution of a gene of interest. In some embodiments, the apparatus comprises a cellstat and a turbidostat. In some...
9771560 High-throughput image-based chemical screening in zebrafish blastomere cell culture  
Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of...
9770535 Scaffolds for cell collection or elimination  
A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that...
9770471 Conversion of somatic cells into functional spinal motor neurons, and methods and uses thereof  
The present invention provides methods of transdifferentiation of somatic cells, for example, directly converting a somatic cell of a first cell type, e.g., a fibroblast into a somatic cell of a...
US20170271601 Organic Light-Emitting Diode Materials  
Described herein are molecules for use in organic light emitting diodes. Example molecules comprise at least one moiety A and at least one moiety D. Values and preferred values of the moieties A...
US20170269029 Nanopore Sensing By Local Electrical Potential Measurement  
There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic...
US20170268061 Methods of Detecting Diseases or Conditions Using Phagocytic Cells  
This invention provides methods of using phagocytic cells in the diagnosis, prognosis, or monitoring of diseases or conditions. The invention also provides methods of using phagocytic cells to...
US20170268022 CAS9 PROTEINS INCLUDING LIGAND-DEPENDENT INTEINS  
Some aspects of this disclosure provide compositions, methods, systems, and kits for controlling the activity of RNA-programmable endonucleases, such as Cas9, or for controlling the activity of...
US20170267630 CLASS-AND ISOFORM-SPECIFIC HDAC INHIBITORS AND USES THEREOF  
HDAC inhibitors of the general formula (I) and (II) and pharmaceutically acceptable salts thereof, as described herein, are useful as inhibitors of histone deacetylases or other deacetylases, and...
US20170266320 RNA-Guided Systems for In Vivo Gene Editing  
Methods of editing target nucleic acids are provided using a guide RNA and a Cas9 protein to excise exons in a target gene and where the edited gene is expressed to produce a truncated polypeptide.
US20170266236 Devices For Wound Healing  
The present invention provides devices and methods for improving wound healing, in particular, in diabetic subjects.
US20170265788 SYSTEMS AND METHODS FOR MAKING AND USING SENSORS, PROBES, AND OTHER DEVICES  
The present invention generally relates, in some aspects, to systems and methods for making and using sensors or other devices, such as optical components. One aspect is generally directed to a...
9766255 Biosensors engineered from conditionally stable ligand-binding domains  
Disclosed is a biosensor engineered to conditionally respond to the presence of specific small molecules, the biosensors including conditionally stable ligand-binding domains (LBDs) which respond...
9765429 Growing films via sequential liquid/vapor phases  
A method for depositing a film on a polymer substrate is disclosed. The method includes exposing a polymer substrate to a liquid comprising a first reactant to provide a plurality of reactive...
9765401 Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer  
Disclosed herein are methods of treating cancer in a subject, and methods for inhibiting growth, migration and/or invasion of a cancer cell in the subject, comprising administering to the subject...
9765341 DNA origami devices  
Provided herein are DNA origami devices useful in the targeted delivery of biologically active entities to specific cell populations.
9764079 Methods and apparatus for isolation of white blood cells using a multiposition valve  
Kits and methods provide for the isolation of white blood cells from bodily fluids. In one exemplary aspect, a method for isolating white blood cells from blood includes the act of adding a blood...
US20170258551 Deposition of RFID Tags  
In a method for printing an RFID tag on an object, a deposition mask is applied to the surface of an object. With the deposition mask on the surface of the object, RFID materials are deposited on...