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US20100047876 |
HIERARCHICAL ASSEMBLY OF POLYNUCLEOTIDES
Methods, compositions and apparatuses for hierarchical assembly of oligonucleotide sequences are provided.
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US20100046039 |
MICROSCOPY IMAGING SYSTEM AND METHOD EMPLOYING STIMULATED RAMAN SPECTROSCOPY AS A CONTRAST MECHANISM
A microscopy imaging system is disclosed that includes a first light source, a second light source, a modulator system, focusing optics, an optical detector, and a processor. The first light source...
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7667497 |
Process variation tolerant circuit with voltage interpolation and variable latency
A circuit having dynamically controllable power. The circuit comprises a plurality of pipelined stages, each of the pipelined stages comprising two clocking domains, a plurality of switching...
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7666708 |
Doped elongated semiconductors, growing such semiconductors, devices including such semiconductors, and fabricating such devices
A bulk-doped semiconductor that is at least one of the following: a single crystal, an elongated and bulk-doped semiconductor that, at any point along its longitudinal is, axis, has a largest...
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US20100035885 |
COMPOSITIONS FOR MANIPULATING THE LIFESPAN AND STRESS RESPONSE OF CELLS AND ORGANISMS
Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and...
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US20100035225 |
ADAPTIVE SPACED TEACHING METHOD AND SYSTEM
The system of the present invention provides interactive spaced education and combines the pedagogical merits of the spacing effect and the testing effect to improve a learner's ability to learn...
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7659053 |
Methods of alteration of surface affinities using non-chemical force-creating fields
The present invention provides a series of methods, compositions, and articles for altering a property of a surface (for example, the cytophilicity and/or the hydrophilicity), by exposing at least...
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US20100028931 |
Neurodegenerative diseases and methods of modeling
Disclosed are embryonic stem cells and motor neurons derived from mice carrying transgenic alleles of the normal or mutant human SOD1 gene. Also disclosed are in vitro systems employing such SOD1...
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US20100022495 |
MODULATING ENDOPLASMIC RETICULUM STRESS IN THE TREATMENT OF TUBEROUS SCLEROSIS
Endoplasmic reticulum stress has been found to be associated with the genetic disease tuberous sclerosis. Tuberous sclerosis is cause by defects in the two genes, TSC1 and TSC2. Agents that...
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US20100022012 |
NANOSENSORS
Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be...
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US20100012827 |
METHODS, SYSTEMS, AND APPARATUS FOR STORAGE, TRANSFER AND/OR CONTROL OF INFORMATION VIA MATTER WAVE DYNAMICS
Methods, systems and apparatus for generating atomic traps, and for storing, controlling and transferring information between first and second spatially separated phase-coherent objects, or using a...
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US20100009378 |
Mass Spectrometric Methods and Products
The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
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US20100008944 |
HERPES SIMPLEX VIRUS MUTANT AND USES THEREFORE
The invention generally provides therapeutic and prophylactic compositions that include a replication defective mutant HSV-2 virus having a mutation in a viral host shut-off protein, a herpes...
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US20100007426 |
NONLINEAR PULSE OSCILLATOR METHODS AND APPARATUS
Methods and apparatus for implementing stable self-starting and self-sustaining high-speed electrical nonlinear pulse (e.g., soliton, cnoidal wave, or quasi-soliton) oscillators. Chip-scale...
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US20100006439 |
METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS
Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based...
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US20090324495 |
COMPOUNDS AND METHODS FOR ENZYME-MEDIATED TUMOR IMAGING AND THERAPY
The invention provides methods and compositions, e.g., for tumor imaging and therapy.
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US20090320529 |
METHOD AND APPARATUS FOR MICROMACHINING BULK TRANSPARENT MATERIALS USING LOCALIZED HEATING BY NONLINEARLY ABSORBED LASER RADIATION, AND DEVICES FABRICATED THEREBY
Thermal 3-D microstructuring of photonic structures is provided by depositing laser energy by non-linear absorption into a focal volume about each point of a substrate to be micromachined at a rate...
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7638645 |
Metal (IV) tetra-amidinate compounds and their use in vapor deposition
Metal(IV) tetrakis(N,N′-dialkylamidinates) were synthesized and characterized. Exemplary metals include hafnium, zirconium, tantalum, niobium, tungsten, molybdenum, tin and uranium. These c...
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US20090318338 |
METHODS FOR MODULATING BONE FORMATION AND MINERALIZATION BY MODULATING KRC ACTIVITY
This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including bone formation and mineralization....
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US20090318333 |
Modified Metallothioneins and Methods for Screening and Treatment of Diseases Associated With Oxidative Stress
The present invention is based on the therapeutic potential of a reduced form of thionein. Accordingly, the invention features modified metallothionein or thionein proteins, for example, where at...
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US20090318298 |
Methods for Sequencing DNA
The invention is directed to methods for using sequence by ligation to sequence DNA immobilized on miniaturized, high density bead-based arrays. Methods are provided to fabricate an array of beads...
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US20090317910 |
MULTIPLEX AUTOMATED GENOME ENGINEERING
The present invention relates to automated methods of introducing multiple nucleic acid sequences into one or more target cells.
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US20090315631 |
Methods and Apparatus Utilizing Quantum Inductance of Nanoscale Structures
Methods and apparatus utilizing the quantum inductance of one-dimensional (ID) nanoscale structures (e.g., nanowires, carbon nanotubes). In one exemplary circuit implementation, all elements of a...
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US20090312297 |
METHODS FOR TREATING HYPERCHOLESTEROLEMIA AND ATHEROSCLEROSIS
The invention provides compounds and pharmaceutical compositions that can be used to treat or prevent atherosclerosis, stroke, and other ischemic vascular diseases, dyslipidemia and...
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US20090306534 |
SYSTEMS AND METHODS FOR PREDICTING EFFECTIVENESS IN THE TREATMENT OF PSYCHIATRIC DISORDERS, INCLUDING DEPRESSION
The present invention pertains to the evaluation and/or treatment of psychopathological diseases. In one aspect, information regarding brain activity, coupled with behavior tests (e.g., determining...
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US20090305384 |
Class II Human Histone Deacetylases, and Uses Related Thereto
The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II...
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US20090299213 |
Nanobioelectronics
The present invention generally relates to nanobioelectronics and, in some cases, to circuits comprising nanoelectronic elements, such as nanotubes and/or nanowires, and biological components, such...
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US20090299058 |
3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION
Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol
-2-one and/or its derivatives are provided. Compositions, methods and kits for...
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US20090298191 |
Lateral Flow and Flow-through Bioassay Devices Based On Patterned Porous Media, Methods of Making Same, and Methods of Using Same
Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay...
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US20090298091 |
Modulation of T Cell Recruitment
The instant invention is based, at least in part, on the discovery that T-bet controls ThI cell recruitment to sites of inflammation. This invention pertains to, inter alia, methods of identifying...
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US20090295908 |
Method and device for high-resolution three-dimensional imaging which obtains camera pose using defocusing
A method and device for high-resolution three-dimensional (3-D) imaging which obtains camera pose using defocusing is disclosed. The device comprises a lens obstructed by a mask having two sets of...
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US20090295364 |
Methods of Using a Nanotransfer Printing Stamp Having Conductively Coated Sidewalls
Methods and apparatuses for generating electrically-conductive and/or semi-conductive films, and more specifically, methods and apparatuses for generating conductive and/or semi-conductive films...
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7625706 |
Methods and apparatus for characterizing polynucleotides
Systems and methods for analysis of polymers, e.g., polynucleotides, are provided. The systems are capable of analyzing a polymer at a specified rate. One such analysis system includes a structure...
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US20090285755 |
METHODS FOR TUMOR DIAGNOSIS AND THERAPY
The present invention discloses a method for the enzyme-mediated, site-specific, in-vivo precipitation of a water soluble molecule in an animal. The enzyme is either unique to tumor cells, or is...
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7620281 |
Subwavelength-diameter silica wires for low-loss optical waveguiding
The present invention provides nanometer-sized diameter silica fibers that exhibit high diameter uniformity and surface smoothness. The silica fibers can have diameters in a range of a about 20 nm...
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7619290 |
Nanosensors
Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be...
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US20090281163 |
REGULATORY ELEMENTS THAT MEDIATE RETINAL CELL-SPECIFIC GENE EXPRESSION
Isolated nucleic acid molecules including regulatory elements that direct retinal-cell specific expression are provided. Methods for treating or preventing retinal disorders in a subject are also...
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7616304 |
System and method for providing a tunable optical parametric oscillator laser system that provides dual frequency output for non-linear vibrational spectroscopy and microscopy
A system is disclosed for providing a first electromagnetic field and a second electromagnetic field to vibrational analysis equipment that is responsive to a difference between first and second...
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7615380 |
Methods for modulating an immune response by modulating KRC activity
This invention demonstrates that KRC molecules have multiple important functions as modulating agents in regulating a wide variety of cellular processes including: inhibiting NFkB transactivation,...
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7611892 |
Prostate-specific or testis-specific nucleic acid molecules, polypeptides, and diagnostic and therapeutic methods
The invention provides novel STAMP2 nucleic acid molecules, polypeptides, antibodies, and modulatory compounds for use in methods of diagnosing, treating, and preventing diseases and conditions of...
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US20090263965 |
SELF-ALIGNED BARRIER LAYERS FOR INTERCONNECTS
An interconnect structure for integrated circuits incorporates manganese silicate and manganese silicon nitride layers that completely surrounds copper wires in integrated circuits and methods for...
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US20090253136 |
GENETIC RISK ASSESSMENT TECHNOLOGY FOR EPITHELIAL CANCER INVOLVING GENE-ENVIRONMENT INTERACTION BETWEEN ERCC5 AND TOBACCO USE
Methods and compositions for assessing ERCC5 gene expression in view of certain environmental exposures and determining the risk of an individual for developing one or more epithelial cancers are...
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US20090252686 |
Ex Vivo Hyperpolarization of Imaging Agents
The present invention generally relates to methods for accelerating the ex vivo induction of nuclear hyperpolarization in imaging agents.
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7595260 |
Doped elongated semiconductors, growing such semiconductors, devices including such semiconductors, and fabricating such devices
A bulk-doped semiconductor may be at least one of the following: a single crystal, an elongated and bulk-doped semiconductor that at any point along its longitudinal axis, has a largest...
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US20090240040 |
PURIFICATION OF A BIVALENTLY ACTIVE ANTIBODY USING A NON-CHROMATOGRAPHIC METHOD
The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a...
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7592147 |
Modulation of IL-2 production by T-bet
The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that...
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US20090232738 |
Methods for modulating de novo hepatic lipogenesis by modulating XBP-1 activity
The invention provides methods and compositions for modulating the expression, processing, post-translational modification, stability and/or activity of XBP-1 protein, or a protein in a signal...
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US20090227649 |
Management of Ophthalmologic Disorders, Including Macular Degeneration
A drug may be used in the preparation of a medicament for the treatment or prevention of an ophthalmologic disorder, wherein the drug inhibits, antagonizes, or short-circuits the visual cycle at a...
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US20090227467 |
COMBINATORIAL ROSAMINE LIBRARY TO DETECT CELL-STATE SWITCHING
The present invention relates to the use of rosamine derivative compounds, as described herein, in detecting differentiated forms of a cell type of interest in a sample and in screening for...
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US20090226876 |
Compositions And Methods For Cardiovascular Surgery
The present invention relates to tissue preservation for autologous and heterologous transplantation. In particular the present invention provides compositions and methods for the long-term storage...
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