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US20090286876 |
NEUROPROTECTIVE BENZOATE AND BENZAMIDE COMPOUNDS
The invention provides a therapeutic method for treating at least one symptom of a neurological disorder or disease such as Alzheimer's disease in a mammal, such as a human, wherein the toxicity of...
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7618827 |
Thyroid hormone analysis by mass spectrometry
Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation...
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7615355 |
Peripheral-type benzodiazepine receptor expression level as an index of organ damage and regeneration
The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for...
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7608264 |
Antibodies that bind to pleiotrophin growth factor receptor
This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including...
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US20090232815 |
ANTIBODIES THAT BIND TO PLEIOTROPHIN GROWTH FACTOR RECEPTOR
This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including...
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US20090216860 |
SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT RELATED INFORMATION
A system and method involves detecting operational social disruptive events on a global scale, assigning disease event staging and warnings to express data in more simplistic terms, modeling data...
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US20090216747 |
System and method for detecting, collecting, analyzing, and communicating event-related information
A system and method involves detecting operational social disruptive events on a global scale, assigning disease event staging and warnings to express data in more simplistic terms, modeling data...
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US20090191261 |
Antibody fragment-targeted immunoliposomes for systemic gene delivery
Nucleic acid-immunoliposome compositions useful as therapeutic agents are disclosed. These compositions preferably comprise (i) cationic liposomes, (ii) a single chain antibody fragment which binds...
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US20090169555 |
Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof
Nucleic acids encoding mouse and human sphingosine kinase type 2 isoforms, methods for detecting agents or drugs which inhibit or promote sphingosine activity and therapeutic agents containing...
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US20090164427 |
AUTOMATED FORENSIC DOCUMENT SIGNATURES
Methods and systems are provided for a proactive approach for computer forensic investigations. The invention allows organizations anticipating the need for forensic analysis to prepare in advance....
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US20090163543 |
Histone Deacetylase Inhibitors and Methods of Use Thereof
One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for...
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7528109 |
Pleiotrophin growth factor receptor for the treatment of proliferative, vascular and neurological disorders
This invention relates to the discovery that pleiotrophin binds to and activates a pleiotrophin-receptor which is responsible for the events associated with pleiotrophin activity including...
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7511027 |
Method of treating hepatitis delta virus infection
A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog that suppresses the expression of the...
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7507828 |
Histone deacetylase inhibitors and methods of use thereof
One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for...
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7498407 |
Vascular endothelial cell growth inhibitor, VEGI-192a
This invention discloses two new VEGI isoforms named VEGI- 192a and VEGI- 192b consisting of 192 amino acid residues. These isoforms show endothelial cell-specific expression and share a...
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US20090053299 |
Methods for generating immune response using cationic-liposome-mediated nucleic acid delivery
The present invention is in the fields of drug delivery, and specifically, cationic liposome-based vaccines. In embodiments, this invention provides methods of making ligand-targeted (e.g.,...
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US20090053178 |
USE OF HERPES VECTORS FOR TUMOR THERAPY
Eliciting a systemic antitumor immune response, in a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type, entails, in one embodiment,...
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7479276 |
Antibody fragment-targeted immunoliposomes for systemic gene delivery
Nucleic acid-immunoliposome compositions useful as therapeutic agents are disclosed. These compositions preferably comprise (i) cationic liposomes, (ii) a single chain antibody fragment which binds...
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7473560 |
Steroid hormone analysis by mass spectrometry
Methods, systems and kits for the simultaneous or sequential analysis of a multitude of steroid hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal...
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7442520 |
Gene BRCC-3 and diagnostic and therapeutic uses thereof
A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and...
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US20080254466 |
Heregulin-like Factor
The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF...
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US20080248566 |
MATRIPTASE, A SERINE PROTEASE AND ITS APPLICATIONS
The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or...
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7427689 |
ErbB-2 selective small molecule kinase inhibitors
A novel method for erbB-2 kinase inhibition by compounds identifies through computational modeling and data processing and/or rational and de novo drug design is provided the compounds bind erbB-2...
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7419814 |
Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof
Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine...
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US20080176821 |
LIGANDS FOR METABOTROPIC GLUTAMATE RECEPTORS AND INHIBITORS OF NAALADASE
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or...
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US20080175849 |
IMMUNOREACTIVE PEPTIDES FROM EPSTEIN-BARR VIRUS
Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment...
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US20080138277 |
Delivery systems and methods for diagnosing and treating cardiovascular diseases
The invention relates to the treatment and prevention of atherosclerosis and cardiovascular diseases associated with atherosclerosis. The invention further relates to methods of diagnosing...
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US20080132486 |
Ligands for Nicotinic Acetylcholine Receptors, and Methods of Making and Using Them
One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of...
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7381745 |
Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or...
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7378403 |
Akt inhibitors, pharmaceutical compositions, and uses thereof
Disclosed are inhibitors of the serine/threonine kinase Akt, pharmaceutical compositions comprising such inhibitors, and a method of preventing or treating a disease or condition in an animal by...
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US20080113340 |
Diagnosis and treatment of cervical cancer
In certain aspects, the invention relates to methods of diagnosing cervical cancer by using a combination of certain biomarkers such as hTERT, IGFBP-3, transferrin receptor, beta-catenin, Myc-HPV...
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7355015 |
Matriptase, a serine protease and its applications
The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or...
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7351811 |
Gene SCC-112 and diagnostic and therapeutic uses thereof
A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. SCC-112 (about 150 kDa) and/or a mutant form of SCC-112 (about 65 kDa) is a tumor suppressor molecule....
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7335738 |
Heregulin-like factor
The present invention relates to a novel HLF protein which is a member of the heregulin family. In particular, isolated nucleic acid molecules are provided encoding the human HLF protein. HLF...
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US20080031812 |
REDOX-STABLE, NON-PHOSPHORYLATED CYCLIC PEPTIDE INHIBITORS OF SH2 DOMAIN BINDING TO TARGET PROTEIN, CONJUGATES, THEREOF, COMPOSITIONS AND METHODS OF SYNTHESIS AND USE
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7326535 |
Immunoreactive peptides from Epstein-Barr virus
Epstein-Barr virus (EBV) specific polypeptides are disclosed. Also disclosed are the use of these polypeptides for the production of polypeptide-specific antibodies and the diagnosis and treatment...
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US20070276140 |
Chiral 1,8-Diarylnaphthalenes, Methods of Making Them, and Their Use as Sensors
One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the...
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US20070269539 |
Ginkgo Biloba Extract as a Treatment for Therapeutic-Induced Neurotoxicity
The invention features methods for treating neurotoxicity associated with therapeutic agents, e.g., chemotherapeutic agents, and compositions and kits for use therein. The methods employ an extract...
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US20070259336 |
Methods for the detection of analytes in a sample
A method for detecting the presence or concentration of an analyte in a sample, wherein: a) the sample is contacted with an immobilized first binding reagent which is capable of binding the analyte...
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7282576 |
Coactivators in the diagnosis and treatment of breast cancer
This invention relates to the AIB1 protein as a coactivator that potentiates the transcriptional activity of nuclear hormone receptors. The gene is amplified in a subset of human breast cancers....
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7279306 |
Stable (fixed) forms of viral capsid proteins, and viral capsid protein fusions, preferably papillomavirus L1 proteins, and uses thereof
Novel acetone- or alcohol-fixed viral capsid proteins, bacteria-containing, and papillomavirus L1-GST fusion proteins are described. These proteins are useful in vaccine preparation and as...
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US20070231378 |
Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said...
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US20070219194 |
PHENYLALANINE DERIVATIVES
The present invention provides phenylalanine derivatives that inhibit SH2 domain binding with a phosphoprotein. These derivatives include compounds of the formula: W—Y-(AA) n -Z wherein n is 0 to...
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7267977 |
Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer
The expression and subcellular localization of peripheral-type benzodiazepine receptors (PBR) is shown in this application to correlate with the metastatic potential of cells, and increased cell...
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7262173 |
Chemosensitizing with liposomes containing oligonucleotides
The invention relates to the use of oligonucleotide containing cationic liposomal formulations to enhance the efficacy of chemotherapy and/or radiotherapy, particularly as a means to sensitize...
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7253272 |
Gene BRCC-2 and diagnostic and therapeutic uses thereof
A gene that is a modulator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for detecting and...
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7244565 |
Gene shinc-3 and diagnostic and therapeutic uses thereof
The invention provides a SHINC-3 polynucleotide, which can be a nucleic acid encoding all or a portion of a SHINC-3 protein, or a complementary polynucleotide or antisense polynucleotide. In...
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7226991 |
Phenylalanine derivatives
Disclosed herein are phenylalanine derivative compounds of the following formula
W—Y—(AA) n —Z
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US20070087992 |
Anti-apoptopic gene SCC-S2 and diagnostic and therapeutic uses thereof
A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for...
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7202279 |
Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective...
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