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US20120128693 |
CADHERIN-11 INHIBITORS AND METHODS OF USE THEREOF
Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
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US20120107833 |
Antibody specific for a mammalian sphingosine kinase type 2 isoform protein and methods of use thereof
Polyclonal or monoclonal antibodies which are specific for a mammalian sphingosine kinase type 2 isoform protein and methods for detecting the presence of sphingosine kinase type 2 isoform using...
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8163805 |
Small molecule antagonists of Bcl-2 family proteins
The present invention relates to naturally occurring and chemically synthesized small molecule antagonists of Bcl-2 family proteins. In particular, the present invention provides gossypol compounds...
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8153657 |
Dopamine-, norepinephrine- and serotonin-transporter-selective heterocyclic compounds and their therapeutic applications
One aspect of the invention relates to piperidine compounds that are useful as inhibitors of monoamine transporters. The invention also relates to pharmaceutical compositions, comprising a...
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8138749 |
Optical imaging and patterning based on a magnetically controlled ferrofluid
Methods, systems, and apparatus for optical imaging and patterning based on a magnetically controlled ferrofluid are described. One such system includes a substrate and an active region including...
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US20120065088 |
SEQUENCE-SPECIFIC DETECTION OF NUCLEOTIDE SEQUENCES
A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a...
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US20120055045 |
ORTHOTIC DEVICES
The present invention relates to orthotic devices and footwear. In particular, the present invention relates to orthotic devices comprising a wedge configured to be placed beneath a forefoot.
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8124052 |
Method for identifying targeting domains and methods and compositions comprising the same
The present invention is directed to a method of identifying tissue targeting domains. In particular, the invention relates to methods for identifying a polynucleotide encoding a targeting domain...
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8097472 |
System and method for the separation of analytes
A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The...
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US20120010487 |
SYSTEMS AND METHODS FOR MONITORING HEALTH AND DELIVERING DRUGS TRANSDERMALLY
The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the...
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US20110317960 |
DIRECT COUPLING OF OPTICAL SLOT WAVEGUIDE TO ANOTHER OPTICAL WAVEGUIDE
Devices, systems and techniques for directly coupling an optical slot waveguide to another optical waveguide without a taper waveguide region between the two optical waveguides.
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US20110301208 |
VIRAL AND FUNGAL INHIBITORS
Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West...
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8067600 |
Histone deacetylase inhibitors and methods of use thereof
One aspect of the invention relates to HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided. The invention also provides methods for...
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US20110269733 |
Silent Desensitizers of Neuronal nAChR and Methods of Use Thereof
One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of...
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US20110269178 |
FLUORESCENT CDK INHIBITORS FOR TREATMENT OF CANCER
Disclosed are molecules and their synthesis. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.
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US20110265008 |
CLINICAL MANAGEMENT SYSTEM FOR CHRONIC ILLNESSES USING TELECOMMUNICATION
Patients with chronic illnesses resist using conventional automated healthcare management systems to supply necessary clinical data because such systems feel impersonal, preferring to actually...
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8044103 |
Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders
The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective...
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US20110256469 |
Platinum Adlayered Ruthenium Nanoparticles, Method for Preparing, and Uses Thereof
A superior, industrially scalable one-pot ethylene glycol-based wet chemistry method to prepare platinum-adlayered ruthenium nanoparticles has been developed that offers an exquisite control of the...
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US20110251294 |
FAST RECOVERY OF THIXOTROPY BY ORGANOGELS WITH LOW MOLECULAR WEIGHT GELATORS
Low molecular weight gelators, methods of making such gelators, organogels comprising such gelators and methods of using such organogels are described. In exemplary methods, the gelators can be...
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US20110251193 |
1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES
Novel classes of 1,2-benzisothiazolinone and isoindolinone compounds and compositions are disclosed. These compounds and compositions are useful in treating, preventing, and/or ameliorating viral,...
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8037535 |
System and method for detecting malicious executable code
A system and method for detecting malicious executable software code. Benign and malicious executables are gathered; and each are encoded as a training example using n-grams of byte codes as...
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8030300 |
Ligands for nicotinic acetylcholine receptors, and methods of making and using them
One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of...
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US20110230442 |
NA CHANNELS, DISEASE, AND RELATED ASSAYS AND COMPOSITIONS
Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have...
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US20110224207 |
FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a...
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US20110217389 |
METHODS FOR TREATING HEAT STRESS AND RELATED COMPOSITIONS
Methods of treating, reducing, and/or preventing heat stress are provided. For example, provided is a method of treating or preventing heat stress in a subject comprising selecting a subject in...
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8012679 |
Papillomavirus vaccines
Seven polyclonal and monoclonal antibodies were characterized for their ability to react specifically with either conformational or non-conformational epitopes of the HPV-1 virion. Using these...
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US20110213146 |
Transition Metal-Catalyzed C-H Amination Using Unactivated Amines
One aspect of the invention relates to a method of animation or amidation, comprising the step of combining a substrate, comprising a reactive C—H bond, and an amine or amide, comprising a r...
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7989491 |
Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections
In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infections by administering...
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US20110182890 |
ANTI-PLEIOTROPHIN ANTIBODIES AND METHODS OF USE THEREOF
The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The...
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7960163 |
Matriptase, a serine protease and its applications
The invention is directed to a method of detecting a malignancy or a pre-malignant lesion in breast or other tissue, or a pathologic condition, by detecting the presence of single-chain or...
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US20110130421 |
Methods and Compositions for the Treatment of Chronic Renal Hypertension
Methods and compositions for the treating chronic renal hypertension in a subject comprising administering a therapeutically effective amount of at least one nitroxide-containing composition to the...
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US20110123980 |
SEQUENCE-SPECIFIC DETECTION OF NUCLEOTIDE SEQUENCES
A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a...
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US20110107253 |
CLINICAL MANAGEMENT SYSTEM FOR CHRONIC ILLNESSES USING TELECOMMUNICATION
Patients with chronic illnesses resist using conventional automated healthcare management systems to supply necessary clinical data because such systems feel impersonal, preferring to actually...
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US20110104301 |
METHODS OF REDUCING PAIN AND INFLAMMATION
Provided herein are methods of treating or preventing pain and/or inflammation in a subject comprising administering to the subject a transient receptor potential (TRP) ion channel inhibitor.
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US20110104252 |
ANTI-APOPTOTIC GENE SCC-S2 AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF
A gene that is a positive mediator of tumor growth and metastasis in certain cancer types is provided. This gene and corresponding polypeptide have diagnostic and therapeutic application for...
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US20110098504 |
Histone Deacetylase Inhibitors and Methods of Use Thereof
The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and...
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7931592 |
Systems and methods for monitoring health and delivering drugs transdermally
The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the...
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US20110081295 |
PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR EXPRESSION LEVEL AS AN INDEX OF ORGAN DAMAGE AND REGENERATION
The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for...
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US20110076214 |
Reversible Room-Temperature Ionic Liquids
One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas...
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US20110071072 |
Antifungal Bone Cements
Antifungal bone cement compositions and methods of using the same are disclosed. In one aspect, a bone cement composition comprises an echinocandin lipopeptide antifungal agent and a cementing...
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US20110045100 |
Antimalarial Quinolines and Methods of Use Thereof
One aspect of the invention relates to substitute quinolines with antimalarial activity, and compositions and kits comprising at least one of them. Another aspect of the invention relates to...
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7888509 |
Chiral 1,8-diarylnaphthalenes, methods of making them, and their use as sensors
One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the...
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7888485 |
Anti-pleiotrophin antibodies and methods of use thereof
The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The...
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US20110021885 |
SUBDURAL ELECTRO-OPTICAL SENSOR
A subdural electro-optical sensor system may include a substrate to which is attached an array of electrodes, light emitters, and light detectors. The sensor system may be sufficiently thin,...
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7872027 |
Low molecular weight Myc-max inhibitors
Compounds and compositions for interfering with the association of Myc and Max are described herein. These compounds and compositions are useful in methods inhibiting growth or proliferation of a...
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7863010 |
Method of assessing progress of kidney regeneration
The present invention relates to methods, reagents, and kits for assessing organ damage, such as damage due to ischemia reperfusion injury, in the course of a transplantation therapy and/or for...
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US20100329981 |
SIMPLIFIED AND IMPROVED METHOD FOR PREPARING AN ANTIBODY OR AN ANTIBODY FRAGMENT TARGETED IMMUNOLIPOSOME FOR SYSTEMIC ADMINISTRATION OF A THERAPEUTIC OR DIAGNOSTIC AGENT
A method of preparing an antibody- or antibody fragment-targeted cationic immunoliposome or polymer complex comprises the steps of (a) preparing an antibody or antibody fragment; (b) mixing said...
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US20100313286 |
G protein-related kinase mutants in essential hypertension
Disclosed are methods for identifying individuals predisposed to essential hypertension and related conditions such as salt sensitivity by detecting the presence of polymorphic or mutant forms of...
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7842835 |
Histone deacetylase inhibitors and methods of use thereof
The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and...
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7825216 |
Phenylanine derivatives
The present invention provides phenylalanine derivatives that inhibit SH2 domain binding with a phosphoprotein. These derivatives include compounds of the formula: W—Y-(AA)n-Z wherein n is 0 to 1...
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