Patents and Patent Applications from Georgetown University


Match Document Document Title
10023905 Polymerase driven NESA  
The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising (a) exposing the target polynucleotide to an initiating oligonucleotide;...
10023551 Glutathione-cleavable prodrug and methods of use thereof  
A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under...
US20180196073 Methods of Assessing Future Memory Loss by Measuring Polyunsaturated Fatty Acids  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty...
10012627 Determining stereoisomeric excess, concentration and absolute configuration  
The present invention is directed to analytical methods for determining the concentration, and/or stereoisomeric excess, and/or absolute configuration of chiral analytes in a sample.
US20180177889 TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES  
The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of...
10004434 Microfluidic systems for electrochemical transdermal analyte sensing using a capillary-located electrode  
A sensing device, designed to be used in contact with the skin, contains a plurality of individually controllable sites for electrochemically monitoring an analyte, such as glucose, in...
US20180169065 USE OF METHADONE METABOLITES FOR TREATMENT OF ANXIETY AND DEPRESSION  
Disclosed are methods of treating anxiety or depression, comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting...
10002034 System and method for detecting, collecting, analyzing, and communicating event-related information  
A system and method involves detecting operational social disruptive events on a global scale, modeling data in conjunction with linguistics analysis to establish responsive actions, and...
US20180166175 DISCOVERY AND ANALYSIS OF DRUG-RELATED SIDE EFFECTS  
Disclosed herein are methods and systems for discovering and analyzing drug related side effects, which are also referred to herein as “off-target responses”. Side effects can be...
9996567 Process and framework for facilitating data sharing using a distributed hypergraph  
A knowledge model “overlay” for organizing and analyzing large, dynamic data volumes is implemented as a hypergraph that manifests as a result of a distributed theory-driven data source...
9994548 Phenyl-substituted nicotinic ligands, and methods of use thereof  
Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety,...
9993465 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof  
Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic...
US20180157786 PREDICTING DRUG-TARGET INTERACTIONS AND USES FOR DRUG REPOSITIONING AND REPURPOSING  
Described herein are methods of predicting drug-target interactions and methods of using the information for drug repurposing. The methods described herein combine different descriptors,...
US20180149665 Metabolic Biomarkers for Memory Loss  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the...
US20180148437 Novel Ezrin Inhibitors and Methods of Making and Using  
The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful...
US20180148401 Compounds and Methods of Use Thereof for Treating Tumors  
The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or...
US20180126004 TREATMENT FOR EXPOSURE TO NERVE AGENT  
The present application provides methods of preventing and treating the toxic effects of exposure to organophosphate agents. In embodiments, targeted cationic liposome complexes delivering nucleic...
9966243 Apparatus and methods for plasma-assisted reaction chemical ionization (PARCI) mass spectrometry  
Plasma-assisted reaction chemical ionization (PARCI) provides highly sensitive elemental analysis by producing positively and negatively charged ions. The PARCI apparatuses, kits, and methods...
US20180121263 SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT-RELATED INFORMATION  
A system and method involves detecting operational social disruptive events on a global scale, modeling data in conjunction with linguistics analysis to establish responsive actions, and...
9951315 Immortalization of epithelial cells and methods of use  
The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder...
US20180106536 Dryer For Preparation of Dry Nanoparticles  
A system for producing dry nanoparticles from a liquid includes a closed tubing system which incorporates a mister, heater and an electrostatic collector therein. The system is able to produce dry...
US20180105505 GLUTATHIONE-CLEAVABLE PRODRUG AND METHODS OF USE THEREOF  
A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under...
9944677 Selective inhibitor of angiotensin II  
Peptides and peptide analogs that selectively inhibit angiotensin II are described. Additionally, a method for making and using the peptides and peptide analogs are also described.
US20180084765 SYSTEMS AND METHODS FOR AUTOMATED CONTROL OF ANIMAL TRAINING AND DISCRIMINATION LEARNING  
Monitoring systems and methods for tracking movement of one or more animals in an enclosure, such as a fish tank, include introducing various stimuli, such as food, light, and auditory stimuli,...
US20180055785 MINT MASK AND METHODS OF USE THEREOF  
Provided are methods and devices useful for treating a respiratory disease or disorder involving the central or upper airways. The methods and devices deliver to central or upper airways of a...
US20180053973 STRIPLINE DETECTOR FOR IN SITU BATTERY AND FUEL CELL NMR  
Provided are batteries and fuel cells incorporating a stripline detector for use in nuclear magnetic resonance (NMR). The stripline batteries and fuel cells can be used for in situ NMR measurement...
9890137 2-halo-5-alkynyl-pyridyl nicotinic ligands  
Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic...
9889131 Cadherin-11 inhibitors and methods of use thereof  
Cadherin-11 inhibitors and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.
9878055 Treatment for exposure to nerve agent  
The present application provides methods of preventing and treating the toxic effects of exposure to organophosphate agents. In embodiments, targeted cationic liposome complexes delivering nucleic...
9849192 Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies  
The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of...
US20170365183 INTELLIGENT MEDICAL HYPERTEXT INFORMATION TRANSLATOR  
Technology for providing a translated content item containing medical terms is disclosed. In one example, a method is used for providing a translated content item and a plurality of actionable...
US20170356861 VIRTUAL BARRICADE FOR RADIATION INSPECTION OF PREDEFINED PATHS  
A method of operating a radiation inspection system includes identifying a regulatory region along a predetermined path where public access is restricted based upon criteria other than radiation...
US20170352444 ROTATING RADIATION SHUTTER COLLIMATOR  
A shutter for controlling radiation exposure includes a rotatable member. The rotatable member is rotatable between an open position and a closed position. The rotatable member includes a...
US20170351742 Application Programming Interface and Hypergraph Transfer Protocol Supporting a Global Hypergraph Approach to Reducing Complexity For Accelerated Multi-Disciplinary Scientific Discovery  
A system and method for connecting one or more client applications with one or more knowledge representation servers and communicating there between includes an application programming interface...
US20170343488 THREE-DIMENSIONAL IMAGE RECONSTRUCTION USING TRANSMISSION AND SCATTER RADIOGRAPHY METHODS  
A method for image reconstruction includes irradiating an object with a beam of radiation from a radiation source, measuring an attenuated portion of the beam, estimating a density of the object,...
9827307 Use of herpes vectors for tumor therapy  
Eliciting a systemic antitumor immune response can be efficacious for a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type. To this end a...
US20170329653 SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT-RELATED INFORMATION  
A system and method involves detecting operational social disruptive events on a global scale, modeling data in conjunction with linguistics analysis to establish responsive actions, and...
US20170326114 COGNITIVE FUNCTION  
Provided herein, inter alia, are compounds useful in improving cognitive function, memory and learning in both healthy and diseased subjects.
9815746 Stereodynamic chemosensors  
The present invention relates to multifunctional chemosensors that can measure the concentration, enantiomeric excess (ee), and absolute configuration of chiral compounds. The chemosensors...
US20170322682 SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT-RELATED INFORMATION  
A system and method involves detecting operational social disruptive events on a global scale, assigning disease or non-disease event staging and warnings to express data in more simplistic terms,...
US20170299549 System and Method For the Separation of Analytes  
A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel....
9789160 Treatments for lowering glucose levels using FGF binding protein 3  
The invention relates to methods of lowering blood glucose levels in a subject, with the methods comprising administering fibroblast growth factor binding protein 3 (FGFBP3) or a variant thereof...
US20170290908 VIRAL VECTORS AND THEIR USE IN THERAPEUTIC METHODS  
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
9778223 System and method for the separation of analytes  
A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel....
9758481 Targeting of EWS-FLI1 as anti-tumor therapy  
Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are...
US20170246259 Compositions and Methods of Using Interleukin-4 Induced Gene 1 (IL-4I1)  
The invention is directed to methods of promoting myelin formation in central nervous system (CNS) tissue in a subject in need thereof, the method comprising administering to the subject a...
US20170246145 Use of Artemisinin for Treating Tumors Induced by Oncogenic Viruses and for Treating Viral Infections  
In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering...
9746985 System and method for detecting, collecting, analyzing, and communicating event-related information  
A system and method involves detecting operational social disruptive events on a global scale, assigning disease or non-disease event staging and warnings to express data in more simplistic terms,...
9737256 Apparatus and methods for non-invasive assessment of transplant kidney viability  
A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their...
US20170216287 TREATING NEURAL DISEASE WITH TYROSINE KINASE INHIBITORS  
Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising administering a tyrosine kinase inhibitor.