Patents and Patent Applications from Georgetown University


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US20170352444 ROTATING RADIATION SHUTTER COLLIMATOR  
A shutter for controlling radiation exposure includes a rotatable member. The rotatable member is rotatable between an open position and a closed position. The rotatable member includes a...
US20170351742 Application Programming Interface and Hypergraph Transfer Protocol Supporting a Global Hypergraph Approach to Reducing Complexity For Accelerated Multi-Disciplinary Scientific Discovery  
A system and method for connecting one or more client applications with one or more knowledge representation servers and communicating there between includes an application programming interface...
US20170343488 THREE-DIMENSIONAL IMAGE RECONSTRUCTION USING TRANSMISSION AND SCATTER RADIOGRAPHY METHODS  
A method for image reconstruction includes irradiating an object with a beam of radiation from a radiation source, measuring an attenuated portion of the beam, estimating a density of the object,...
9827307 Use of herpes vectors for tumor therapy  
Eliciting a systemic antitumor immune response can be efficacious for a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type. To this end a...
US20170329653 SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT-RELATED INFORMATION  
A system and method involves detecting operational social disruptive events on a global scale, modeling data in conjunction with linguistics analysis to establish responsive actions, and...
US20170326114 COGNITIVE FUNCTION  
Provided herein, inter alia, are compounds useful in improving cognitive function, memory and learning in both healthy and diseased subjects.
9815746 Stereodynamic chemosensors  
The present invention relates to multifunctional chemosensors that can measure the concentration, enantiomeric excess (ee), and absolute configuration of chiral compounds. The chemosensors...
US20170322682 SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EVENT-RELATED INFORMATION  
A system and method involves detecting operational social disruptive events on a global scale, assigning disease or non-disease event staging and warnings to express data in more simplistic terms,...
US20170299549 System and Method For the Separation of Analytes  
A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel....
9789160 Treatments for lowering glucose levels using FGF binding protein 3  
The invention relates to methods of lowering blood glucose levels in a subject, with the methods comprising administering fibroblast growth factor binding protein 3 (FGFBP3) or a variant thereof...
US20170290908 VIRAL VECTORS AND THEIR USE IN THERAPEUTIC METHODS  
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
9778223 System and method for the separation of analytes  
A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel....
9758481 Targeting of EWS-FLI1 as anti-tumor therapy  
Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are...
US20170246259 Compositions and Methods of Using Interleukin-4 Induced Gene 1 (IL-4I1)  
The invention is directed to methods of promoting myelin formation in central nervous system (CNS) tissue in a subject in need thereof, the method comprising administering to the subject a...
US20170246145 Use of Artemisinin for Treating Tumors Induced by Oncogenic Viruses and for Treating Viral Infections  
In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering...
9746985 System and method for detecting, collecting, analyzing, and communicating event-related information  
A system and method involves detecting operational social disruptive events on a global scale, assigning disease or non-disease event staging and warnings to express data in more simplistic terms,...
9737256 Apparatus and methods for non-invasive assessment of transplant kidney viability  
A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their...
US20170216287 TREATING NEURAL DISEASE WITH TYROSINE KINASE INHIBITORS  
Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising administering a tyrosine kinase inhibitor.
US20170213028 METHODS, SYSTEMS, AND COMPUTER READABLE MEDIA FOR DETECTING COVERT TIMING CHANNELS  
A mechanism called time-deterministic replay (TOR) that can reproduce the execution of a program, including its precise timing. Without TOR, reproducing the timing of an execution is difficult...
9714222 Methods and compositions for treating Ewings sarcoma family of tumors  
Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.
9708521 Systems and methods employing low molecular weight gelators for crude oil, petroleum product or chemical spill containment and remediation  
Low molecular weight gelators, methods of making such gelators, organogels comprising such gelators and systems and methods of using such gelators for the containment and/or remediation of a...
US20170192018 METABOLIC BIOMARKERS FOR MEMORY LOSS  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the...
9695108 Compounds and methods of use thereof for treating tumors  
The invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or...
US20170184613 EXOSOME AND LIPID BIOMARKERS FOR MEMORY LOSS  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one sample from the subject...
US20170183733 GENETIC MARKERS FOR MEMORY LOSS  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing the gene expression profile from...
9682225 Polymer film bioelectrodes and methods of making and using the same  
Bioelectrodes, methods of making bioelectrodes and methods of using bioelectrodes are provided. The bioelectrodes have an electrically-conductive substrate coated with an electroconductive...
9682094 Targeting matriptase expressing tumor cells with chemotherapeutic agents conjugated to matriptase antibodies  
The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of...
US20170165254 TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF  
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a...
9677072 Methods of inhibiting proliferation of estrogen-independent cancer cells  
The invention relates to methods of inhibiting the growth or proliferation of a cell, the method comprising reducing the expression or activity of at least one gene in the cell selected from the...
US20170157089 METHODS AND COMPOSITIONS FOR TREATING CANCER  
Methods and compositions provided herein relate to the treatment of cancer. In some embodiments, the compositions have utility in the treatment of cancers including glioblastoma multiforme and...
US20170154410 ENHANCING THE LEGIBILITY OF IMAGES USING MONOCHROMATIC LIGHT SOURCES  
A system and method are described for enhancing readability of document images by operating on each document individually. Monochromatic light sources operating at different wavelengths of light...
US20170147510 SYSTEM AND METHOD FOR DETERRING MALICIOUS NETWORK ATTACKS  
A system and method for deterring malicious network attacks. The system and method is configured to execute instructions on at least one of the processors to generate a plurality of random blocks...
9657272 Immortalization of epithelial cells and methods of use  
The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder...
US20170136134 Manganese-Oxo Clusters as Contrast Agents for Magnetic Resonance Imaging  
Nanoparticles for use as magnetic resonance imaging contrast agents are described. The nanoparticles are made up of a polymeric support and a manganese-oxo or manganese-iron-oxo cluster having...
9642846 Antifungal drugs  
The present invention relates to the administration of compounds of formula (I) for the treatment and/or prevention of fungal infections in subjects in need thereof. The methods of the invention...
US20170107197 PHENYL-SUBSTITUTED NICOTINIC LIGANDS, AND METHODS OF USE THEREOF  
Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety,...
US20170098053 TELEGENETICS  
Disclosed herein are systems and methods that utilized a network of dispersed computing systems, specialized software, and other networking technology for providing remote communications for...
US20170087107 BENZENETRICARBOXYLIC ACID AND METHODS OF USE  
Methods of treating or preventing cancer and/or a neurodegenerative disorder in a subject are provided. The methods comprise administering to a subject a therapeutically effective amount of...
9603844 Compositions and methods for treating mammary tumors  
The present invention provides methods of inhibiting abnormal growth of cells, with the methods comprising contacting the cells with at least one of the sensitizing compounds disclosed herein in...
9601697 Systems and process for forming carbon nanotube sensors  
A system for forming a functionalized sensor for sensing a molecule of interest includes at least one single or multi-wall carbon nanotube having a first and a second electrode in contact...
US20170052204 Metabolic and Genetic Biomarkers for Memory Loss  
The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the...
US20170049182 ORTHOTIC DEVICES  
The present invention relates to orthotic devices and footwear. In particular, the present invention relates to orthotic devices comprising a wedge configured to be placed beneath a forefoot.
9567641 Combination therapy for the treatment of cancer using an anti-C-met antibody  
A target substance used for combination treatment with an anti-c-Met antibody, a pharmaceutical composition for combination administration for preventing and/or treating cancer including an...
US20170038316 SYSTEM AND METHOD FOR INTERNAL INSPECTION OF RAIL COMPONENTS  
An internal imaging system has a radiation source and a plurality of detectors positioned to receive portions of the plurality of collimated beams that have been attenuated by interaction with the...
US20170035743 2,5-Disubstituted-Pyridyl Nicotinic Ligands, and Methods of Use Thereof  
Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic...
US20170035331 Apparatus and Method For Delivery of Antimicrobial During a Transdermal Sampling and Delivery Process  
A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically...
9562258 Sequence-specific detection of nucleotide sequences  
A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a...
9555134 Manganese-oxo clusters as contrast agents for magnetic resonance imaging  
Nanoparticles for use as magnetic resonance imaging contrast agents are described. The nanoparticles are made up of a polymeric support and a manganese-oxo or manganses-iron-oxo cluster having...
9555072 Viral vectors and their use in therapeutic methods  
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
US20170022562 Biomarkers and Therapeutic Targets for Abnormal Retinal Pigment Epithelium  
The present invention relates to markers and therapeutic targets of abnormal retinal pigment epithelium (RPE).