Patents and Patent Applications from Emory University


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9428815 HIV-1 reverse transcriptase codon deletion and its use in the management and treatment of HIV infections  
The present invention provides an isolated HIV-1 mutant and isolated nucleic acid molecules comprising HIV-RT coding sequences harboring a novel mutation in the S68 codon, and in particular,...
9428478 Piperazine derivatives, compositions, and uses related thereto  
The disclosure relates to piperazine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidase.
US20160244403 Cyclopropyl Derivatives and Methods of Use  
The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions...
US20160243534 Heterocyclic Coupling Catalysts and Methods Related Thereto  
This disclosure relates to synthetic coupling methods using a catalytic molecule comprising two bonded atoms wherein one atom is an amide nitrogen and the second atom is not nitrogen or carbon,...
US20160243121 Quinazoline Derivatives, Compositions, and Uses Related Thereto  
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or...
US20160242745 Systems, Methods and Computer Readable Storage Media Storing Instructions for Image-Guided Interventions Based on Patient-Specific Models  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on strain data and elastic model. The method may include determining, by a processor, a range of...
9421238 Treatment of klebsiella pneumoniae with liposomally formulated glutathione  
The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as...
US20160235765 Methods of Managing Eye Pain and Compositions Related Thereto  
This disclosure relates to methods of managing eye pain, for example, due to eye surgery. In certain embodiments, the disclosure relates to methods comprising administering a local anesthetic in...
US20160235439 Devices, Systems, and Methods for Improving Access to Cardiac and Vascular Chambers  
Devices, systems and methods are provided for enhancing mechanical strength of tissue, allowing direct and secure access to cardiac and vascular structures, either through tiny incisions or...
US20160228533 Use of EGFR Pathway Inhibitors to Increase Immune Responses to Antigens  
This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In...
US20160228466 Glutamate Dehydrogenase 1 Inhibitors and Methods of Treating Cancer  
This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof. In certain...
US20160220595 NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO  
This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside...
9402850 BAX agonist, compositions, and methods related thereto  
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
US20160213691 Treating Various Disorders Using TrkB Agonists  
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
US20160202252 Devices and Methods Related to Airway Inflammation  
This disclosure relates to devices, assays, and methods related to airway inflammation caused by polymorphonuclear neutrophils (PMNs). In certain embodiments, the disclosure relates to a model...
US20160200800 ANTIBODIES DIRECTED AGAINST INFLUENZA  
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly...
US20160199337 Nutritional Formulas Comprising Medium Chain Fatty Acids or Esters Thereof and Methods Related Thereto  
This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain...
US20160194351 Progesterone Phosphate Analogs and Uses Related Thereto  
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing...
9382286 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
9382193 Processes for forming amide bonds and compositions related thereto  
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an...
9381260 Hypoxia inducible factor-1 pathway inhibitors and uses as anticancer and imaging agents  
This disclosure relates to Hypoxia Inducible Factor-1 pathway inhibitors and uses as anticancer and imaging agents. In certain embodiments, the disclosure contemplates compounds and pharmaceutical...
9375465 Conjugates of GM-CSF and IL-7, compositions and methods related thereto  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20160175394 Compositions and Uses of Lectins  
The disclosure relates to uses of a purified or isolated lectin to kill bacteria, viruses, and other pathogens. In certain embodiments, the disclosure relates to method of treating or preventing...
US20160166616 COMPOSITIONS OF ACORBIC ACID AND BONE MORPHOGENETIC PROTEIN 4 (BMP-4) FOR CELL GROWTH AND USES RELATED THEREO  
This disclosure relates to compositions comprising ascorbic acid and bone morphogenetic protein 4 (BMP-4) for growing cells and making tissues. In certain embodiments, this disclosure relates to...
9365523 Imidazolyl amide compounds and uses related thereto  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising...
US20160158308 TREATMENT OF MULTIPLE EVOLVING BACTERIAL RESISTANCE DISEASES WITH LIPOSOMALLY FORMULATED GLUTATHIONE  
The invention proposes routine treatment of patients, particularly those admitted to an ICU, with Vitamin D and liposomal glutathione for prophylaxis and treatment against Group B Streptococcus...
US20160158266 2' FLUORONUCLEOSIDES  
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and...
9358226 Triarylmethane analogs and their use in treating cancers  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
9355309 Generation of medical image series including a patient photograph  
Systems, methods, and computer-readable storage media relate to generate an image series that includes a patient image and a medical image. The patient image and the medical image may be...
US20160149566 Devices, Methods and Computer Readable Storage Media Storing Instructions for Generating Pulse Signals  
Devices, methods, and computer-readable storage media relate to generating a voltage according to a bit pattern. The device may include a memory storing a plurality of bit patterns. Each bit...
US20160146837 DIAGNOSTIC TESTING IN DEMENTIA AND METHODS RELATED THERETO  
This disclosure relates to diagnostic testing for subjects with or at risk of dementia and methods related thereto. In certain embodiments, the disclosure relates to methods of diagnosing a...
US20160146834 DIAGNOSTIC ASSAY TO PREDICT CARDIOVASCULAR RISK  
This invention relates to the area of cardiovascular disorders and specifically relates to methods of diagnostic tests using a combination of markers to predict an individual's risk for developing...
US20160143914 Nanoparticles for Encapsulation and Delivery of Bioactive Compounds and Compositions Thereof  
In certain embodiments, this disclosure relates to nanoparticles for drug-delivery of cytotoxic anti-cancer compounds. In certain embodiments, the nanoparticle comprises a maytansinoid and an...
9345389 Additional systems and methods for providing real-time anatomical guidance in a diagnostic or therapeutic procedure  
A system and method for intra-operatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In embodiments, the system includes multiple light sources configured...
US20160137731 HUMAN ANTI-PD-1, PD-L1, AND PD-L2 ANTIBODIES AND USES THEREFOR  
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing,...
US20160136242 Glial Cell Line Derived Neurotrophic Factor, Obesity, and Obesity-Related Diseases and Conditions  
The disclosure relates to therapeutic methods for regulating weight gain, metabolic syndrome, and insulin resistance. In certain embodiments, the disclosure relates to methods of treating or...
9341619 Hyposialylation disorders  
Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in...
US20160131650 VIRUS-DETECTION KITS AND METHODS OF MAKING AND USING THE SAME  
The present disclosure relates to compositions, kits, and methods for the detection of a virus in a sample. Typically, the sample is from a subject suspected of, exhibiting symptoms of, or...
US20160130328 Pathogen Binding Agents Conjugated to Radioisotopes and Uses in Imaging and Therapeutic Applications  
This disclosure relates to binding agents specific for the envelope protein of a virus, e.g., lentivirus, wherein the binding agent is conjugated to a molecule with a radioisotope or...
9333218 MicroRNA compositions and methods related thereto  
The disclosure relates to microRNAs (miRNAs) for the prophylaxis and/or treatment of neoplasia. The disclosure relates in particular to sequence corresponding to miR2 and the miR-548 family,...
US20160113925 METHODS OF TREATING CANCER WITH A COMBINATION OF GLUCOSE MODULATORS AND BCL-2 INHIBITORS  
This disclosure relates to treating or preventing cancers, such as hematological malignancies, by administering a compound that binds BCL2 and one or more compounds that inhibit glucose or...
US20160113873 NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS  
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
9321829 Antibodies directed against influenza  
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly...
9320875 Systems for implanting and using a conduit within a tissue wall  
Various embodiments of the present invention provide a conduit system including an outer lumen (810), an inner lumen (805), and an attaching device (820). In other embodiments, a multiple access...
9320509 Suturing devices, systems and methods of using the same  
Provided herein are surgical suturing systems, devices, and methods of using the same. The systems and devices are optionally used in surgeries of the stomach.
US20160108092 Selectin Inhibitors, Composition, and Uses Related Thereto  
This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one more modified amino...
US20160106684 CASEIN COATED DRUG-LOADED IRON OXIDE NANOPARTICLES  
This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising...
US20160102048 N-(4-(BIS(4-(DIMETHYLAMINO)PHENYL)METHYLENE)-8-(DIMETHYLAMINO)  
This disclosure relates to N-(4-(bis(4-(dimethylamino)phenyl)methylene)-8-(dimethylamin o)naphthalen-1(4H)-ylidene)-N-methylmethanaminium, derivatives, and uses related thereto. In certain...
9308015 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20160095859 COMBINATION THERAPIES FOR OVERCOMING RESISTANCE TO MITOTIC AGENTS DURING CHEMOTHERAPY  
This disclosure relates to the uses of compounds that target an interaction between CHFR and PARP1. In certain embodiments, the disclosure relate to treating cancer by administering a mitotic...