Patents and Patent Applications from Emory University


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US20180171287 Methods of Measuring Cell Purity for Making Quality Control Determinations and Related Compositions  
This disclosure relates to methods of detecting and quantifying low concentrations of cells in a sample with targeted nanoparticles having Raman reporters using surface-enhanced Raman scattering...
US20180169215 Multivalent Enterovirus Vaccine Compositions and Uses Related Thereto  
This disclosure relates to multivalent enterovirus vaccine compositions and uses related thereto. In certain embodiments, the disclosure relates to vaccine compositions comprising multivalent,...
9999666 Uses of conjugates of GM-CSF and IL-7 to treat viral infections  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20180161000 Systems, Methods and Computer Readable Storage Media Storing Instructions for Generating Planning Images Based on HDR Applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
9994823 Purification of cell mixtures using molecular beacons targeting cell specific RNA  
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular...
9993575 Nanoenhanced hemostatic device and methods for making a layer having hemostatic properties  
Devices and methods relate to inducing or promoting hemostasis. The hemostasis device may include a support layer having a first surface and an opposing second surface. The device may include a...
US20180155439 Compositions and Conjugates Comprising an Interleukin and Polypeptides That Specifically Bind TGF-beta  
This disclosure relates to compositions and conjugates comprising an interleukin, e.g., IL-15 and a polypeptide that specifically binds TGF-beta. Typically the polypeptide that specifically binds...
US20180155430 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
9987356 Anti-CD40 antibodies and methods of administering thereof  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
US20180148755 Oligosaccharide Libraries and Methods of Production  
This disclosure relates to libraries of oligosaccharides comprising multiple individual oligosaccharides derived from cells that contain a tag or detectable marker. In certain embodiments, the tag...
US20180147190 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide Compounds for the Management of CFTR Protein Mediated Diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
US20180147164 2-amino-N'-benzylideneacetohydrazides and Derivatives for the Management of CFTR Protein Mediated Diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
9980936 BH4 antagonists and methods related thereto  
The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
US20180143194 COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCOUS INFECTIONS  
Provided herein are compositions and methods for detecting and/or diagnosing a Staphylococcus aureus (S. aureus) infection in a subject. It is a surprising finding of the present invention that an...
9975868 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20180128833 METHODS OF TREATING WITH TUMOR MEMBRANE VESICLE-BASED IMMUNOTHERAPY AND PREDICTING THERAPEUTIC RESPONSE THERETO  
Disclosed herein is a method for treating a subject having, or at risk of having, a triple negative breast cancer, comprising administering to the subject a therapeutically effective amount of an...
US20180127713 Method of Producing Stem Cell-Derived Endothelial Cells and Uses Thereof  
This disclosure relates to methods of generating endothelial cells derived from stem cells. In certain embodiments, the cells are useful for inducing vasculature in muscles and cardiac tissue. In...
US20180125991 OLIGOSACCHARIDE CONJUGATES FOR TARGETING BACTERIA AND USES RELATED THERETO  
This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria...
US20180125967 HIV Immune Stimulating Compositions Comprising Recombinantly Expressed Pili on Bacteria and Methods Related Thereto  
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant...
US20180125812 Dehydroacetic Acid (DHAA) and Derivative for Uses in Treating Cancer  
This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or other agents that antagonize...
9962423 Protein particles comprising disulfide crosslinkers and uses  
This disclosure relates to particles comprising recombinant proteins, pharmaceutical composition comprising the particles, and therapeutic uses related thereto. In certain embodiments, the...
US20180121600 Methods, Systems and Computer Readable Storage Media for Generating Accurate Nucleotide Sequences  
Methods, systems and computer-readable storage media relate to generating one or more consensus sequences. The methods may include determining a group of one or more reads with each main position...
US20180117145 Immunostimulatory Compositions, Particles, and Uses Related Thereto  
In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition...
US20180116958 NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS  
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
9957300 Virus-like particles, methods of preparation, and immunogenic compositions  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using...
9950168 Methods for intracardiac surgery and intracardiac delivery of therapies and devices  
A method of performing an intracardiac procedure using controlled intermittent diastolic arrest (CIDA) to expand the chambers of the heart to a volume between about 75 to 200% of their normal...
9950146 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20180104243 Tricyclic Amino Containing Compounds for Treatment or Prevention of Symptoms Associated with Endocrine Dysfunction  
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
9944901 Fusion protein for inducing pluripotent stem cells and application method thereof  
Provided is a protein coded by a gene related to cell totipotency and a transcriptional activation domain of a mammalian YAP protein or a fusion protein of a segment with a transcriptional control...
US20180094018 Progesterone Phosphate Analogs and Uses Related Thereto  
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing...
US20180092876 Treating or Preventing Nephrogenic Diabetes Insipidus  
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in...
9932585 Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto  
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of...
9932344 Pyrazolo[1,5-A]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use  
Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (CDK) (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.) are...
9932326 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
9932317 Quinazoline compounds and their use in therapy  
This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in...
9926359 Optogenetic inhibition of overactive neuronal activity  
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain...
9926295 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
9919163 Methods, systems and computer readable storage media for determining optimal respiratory phase for treatment  
Methods, systems and computer-readable storage media relate to determining optimal treatment information. The methods may include determining a dose distribution for one or more target regions by...
US20180066323 Biomarkers in Cancer, Methods, and Systems Related Thereto  
This disclosure relates biomarkers of cancer, e.g. prostate cancer. The biomarkers may be altered expression of nucleic acids, mutations, or proteins encoded therefrom. In certain embodiments, the...
9907797 Combination therapies for overcoming resistance to mitotic agents during chemotherapy  
This disclosure relates to the uses of compounds that target an interaction between CHFR and PARP1. In certain embodiments, the disclosure relate to treating cancer by administering a mitotic...
US20180057817 Particle-Nucleic Acid Conjugates and Therapeutic Uses Related Thereto  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...
US20180057517 Metal Tricarbonyl Complexes Comprising Substituted Iminodiactic Acid Ligands and Uses as Radioisotope Tracers  
This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments,...
9901548 Compositions for encapsulating biomaterials and uses related thereto  
This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments, the disclosure relates to capsules comprising...
US20180052161 BIOMARKERS FOR MALARIA DIAGNOSIS  
Disclosed herein are methods of detecting Plasmodium in a subject (for example, presence of Plasmodium parasite) by detecting the presence and/or amount of one or more metabolites in a sample from...
9895344 Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof  
Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of...
US20180042985 Methods of Improving Behavioral Therapies  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
US20180042956 Glutamate Dehydrogenase 1 Inhibitors and Methods of Treating Cancer  
This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof.
9884815 PGAM1 inhibitors and methods related thereto  
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1...
US20180028357 METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
9877697 Systems, methods and computer readable storage media storing instructions for generating planning images based on HDR applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...