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Patents and Patent Applications from Emory University


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US20140107566 METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
US20140105974 COMPOSITIONS FOR ENCAPSULATING BIOMATERIALS AND USES RELATED THERETO  
This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments the disclosure relates to capsules comprising a...
US20140105931 HEPATITIS C VIRUS PARTICLES, VACCINES, COMPOSITIONS AND METHODS RELATED THERETO  
This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and administered to a subject to illicit...
US20140105828 NANOPARTICLES CARING NUCLEIC ACID CASSETTES FOR EXPRESSING RNA  
This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression...
US20140105826 REDUCED DYE PROBES FOR THE DETECTION OF RADICAL OXYGEN SPECIES  
Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or...
8697846 Methods of making monoclonal antibodies using fusion-peptide epitope adoptive transfer (F-PEAT) technology  
Disclosed are compositions and methods for related to monoclonal antibodies specific for single amino acid variation in an antigen.
8694337 Display of patient-specific data  
Systems, methods, and computer-program products identify clinical data corresponding to a plurality of patients located within a common health care delivery unit, and apply one or more rules to at...
8691777 Combination therapy  
The disclosure relates to methods of treating tuberous sclerosis in a subject, comprising administering a composition comprising an mTOR inhibitor and a tyrosine kinase inhibitor to a subject that...
US20140093497 ANTI-CD40 ANTIBODIES AND USES THEREOF  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
US20140081133 SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE  
According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light...
US20140080828 IMIDAZOLYL AMIDE COMPOUNDS AND USES RELATED THERETO  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising...
US20140073833 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR DETERMINING PATIENT SPECIFIC TREATMENT PLANNING MARGINS  
Methods, systems and computer-readable storage media relate to determining individualized treatment planning margins. The methods may include processing motion data of a target obtained from at...
US20140066395 PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS  
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2,...
8652465 Methods and compositions for the treatment of persistent infections  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
US20140046039 ANTIBODIES DIRECTED AGAINST INFLUENZA  
Antibodies or antibody fragments, wherein the antibody or the fragment binds HA domain of influenza virus (e.g. H1N1, H5N1, or both). Also described are cloned human antibodies that bind influenza
US20140045936 CYCLOPROPYL DERIVATIVES AND METHODS OF USE  
The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed...
8647125 Apparatuses and methods for simulating microlaryngeal surgery  
Apparatus for simulating microlaryngeal surgery. In one embodiment, the apparatus includes a larynx model that emulates an actual larynx, the larynx model including an inner passage that includes a...
US20140039615 DEVICES AND METHODS FOR SURGICAL AND PERCUTANEOUS REPAIR OF HEART VALVE LESIONS  
The devices and methods relate to surgical and percutaneous repair of heart valve regions. The devices may be structured to conform to the desired shape of a specific patient. The devices may...
US20140039375 SYSTEMS FOR IMPLANTING AND USING A CONDUIT WITHIN A TISSUE WALL  
Various embodiments of the present invention provide a conduit system including an outer lumen (810), an inner lumen (805), and an attaching device (820). In other embodiments, a multiple access...
US20140039187 CXCR4 ANTAGONISTS FOR THE TREATMENT OF MEDICAL DISORDERS  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
US20140038887 GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR, OBESITY, AND OBESITY-RELATED DISEASES AND CONDITIONS  
The disclosure relates to therapeutic methods for regulating weight gain, metabolic syndrome, and insulin resistance. In certain embodiments, the disclosure relates to methods of treating or...
8637459 Enhancing a population of insulin releasing cells using GFR-A1 agonists  
Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to...
8636713 Methods and devices for drug delivery to ocular tissue using microneedle  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
US20140025163 SYSTEMS, DEVICES AND METHODS FOR SURGICAL AND PRECUTANEOUS REPLACEMENT OF A VALVE  
The systems, devices and methods relate surgical and percutaneous replacement of a valve. The devices may include a frame and artificial leaflets. The devices may include one frame or two frames....
US20140024047 COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF  
The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific...
US20140023715 POLYMER CONJUGATES TARGETING CELLS AND METHODS RELATED THERETO  
This disclosure relates to polymer coated particles targeting cancer cells and methods related thereto. In certain embodiments, the disclosure relates to nanoparticles coated with amphiphilic...
8628753 Reduced dye probes for the detection of radical oxygen species  
Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or...
US20140010886 COMPOSITIONS COMPRISING SACCHARIDE BINDING MOIETIES AND METHODS FOR TARGETED THERAPY  
The disclosure relates to uses of saccharide binding moieties, e.g., lectins for targeting cells, typically cancer stem cells. In certain embodiments, the disclosure relates to conjugates...
8623379 Compositions and methods for generating an immune response  
We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes,...
US20140005595 DELIVERY DEVICES AND METHODS FOR DELIVERING THERAPEUTIC AGENTS  
Devices and methods for delivering therapeutic agents use a movable sheath member to deliver a therapeutic agent with little or no shear stress. The delivery device may include an outer body being...
8618077 Compositions and methods for treating fragile X premutation RVGG repeats-mediated toxicity  
Compositions and methods of treatment or prophylaxis of fragile-X associated disorders are provided, as well as methods of screening compounds and kits to screen a library of compounds.
US20130344165 JAB1 INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO  
This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a...
D696094 Accessory clamp  
8614203 Methods for the treatment of a central nervous system injury via a tapered administration protocol  
The present invention provides methods for the treatment or the prevention of neuronal damage in the CNS. Specifically, the methods of the invention provide for the administration of a...
US20130338208 FULVENE AND FULVALENE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and...
US20130337471 CELL IDENTIFICATION WITH NANOPARTICLES, COMPOSITIONS AND METHODS RELATED THERETO  
The present disclosure provides a method for identifying rare or low-abundant biological entities such as Hodgkin's and Reed-Sternberg cells, circulating tumor cells in peripheral blood,...
US20130337082 NOGGIN INHIBITORY COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO  
This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting a...
8609870 Treating various disorders using TrkB agonists  
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
8609627 Purine nucleoside monophosphate prodrugs for treatment of cancer and viral infections  
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2,...
US20130331777 DELIVERY DEVICES AND METHODS FOR DELIVERING THERAPEUTIC AGENTS  
Devices and methods for delivering therapeutic agents use an inverted member to deliver a therapeutic agent with little or no shear stress. The inverted member may have a movable continuous...
US20130331280 COMPOSITIONS AND METHODS FOR FUNCTIONAL GYLCOMICS  
The disclosure relates to labeling glycans and glycosphingolipids from undefined mixtures with chemical moieties that emit light when exposed to electromagnetic radiation and uses of these labeled...
8606725 Automatic client-side user-behavior analysis for inferring user intent  
User intent may be inferred from mouse movements made within a user interface. Client-side instrumentation may be provided that collects mouse movement data that is provided to a classification...
US20130324552 CHEMOKINE CXCR4 RECEPTOR MODULATORS AND USED RELATED THERETO  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
US20130324503 Method of identifying and treating a person having a predisposition to or afflicted with Parkinson disease  
The present invention relates to methods of treatment for Parkinson Disease (PD) in a person by identifying gene variants which may indicate a more favorable response to specific medicaments,...
US20130310350 METHOD FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CANCERS AND COMPOSITIONS RELATED THERETO  
Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is...
US20130308849 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIUMS STORING INSTRUCTIONS FOR 3D REGISTRATION OF MEDICAL IMAGES  
Systems, methods and computer-readable storage mediums relate to processing to segment ultrasound images of an object. The processing may be based on three different planes. The processing may...
US20130302351 ANTAGONISM OF THE VIP SIGNALING PATHWAY  
The disclosure relates to inhibition of the VIP signaling pathway. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection comprising administering a...
8569305 Treatment of tuberous sclerosis associated neoplasms  
The present invention relates to the use of PDGF receptor tyrosine kinase or bcr-abl tyrosine kinase inhibitors, especially of N-phenyl-2-pyrimidine-amine derivatives of formula I, in which the...
8568311 Display enhanced testing for concussions and mild traumatic brain injury  
Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive...
8563305 Rapid generation of antibodies  
High efficient methods for producing an antibody molecule that binds an antigen are described. The methods include obtaining a population of PBMC enriched for CD19highCD3negCD20low to...