Patents and Patent Applications from Emory University


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US20180228924 Methylsulfonamide Derivatives and Uses Related Thereto  
This disclosure relates to methylsulfonamide derivatives and uses as imaging agents and other uses related to CXCR4 inhibition. In certain embodiments, the disclosure relates to pharmaceutical...
10045989 Quinazoline derivatives, compositions, and uses related thereto  
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or...
US20180221390 Steroid Analogues for Neuroprotection  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
10041945 Methods of diagnosing and treating tuberculosis  
This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of CD4+ cells. In certain embodiments,...
10040783 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
10034931 Use of EGFR pathway inhibitors to increase immune responses to antigens  
This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In...
US20180207166 Compounds and Compositions for Ossification and Methods Related Thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
10030053 Immunogenic compositions and methods of use thereof  
Embodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host. Embodiments of the compositions encompass proteins derived from the...
US20180200492 CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
10023842 Endothelial and endothelial like cells produced from fibroblasts and uses related thereto  
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the disclosure relates to methods of...
10022378 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
US20180193404 COMPOSITION FOR TREATMENT OF RSV  
This invention relates to a composition, the use of a composition for treatment, and a method of treatment of infection with Respiratory syncytial virus (RSV). The composition for treatment is a...
10016408 Chemokine CXCR4 receptor modulators and uses related thereto  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
US20180186762 7,8-DIHYDOXYFLAVONE AND 7,8-SUBSTITUTED FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20180185372 USE OF TREM-1 INHIBITORS FOR TREATMENT, ELIMINATION AND ERADICATION OF HIV-1 INFECTION  
Compounds, compositions, and methods of treatment and prevention of HIV, including HIV-1 and HIV-2, Dengue, and Chikungunya infection are disclosed. The compounds are TREM-1 inhibitors....
10011656 Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor  
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing,...
10011629 Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer  
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile...
10010526 Heterocyclic flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
US20180179495 Growth and Survival Compositions for Cells Capable of Producing Antibodies and Methods Related Thereto  
This disclosure relates to growth media and environments for in vitro culturing of cells that produce or are capable of producing antibodies. In certain embodiments, the media comprises IL-6,...
US20180171287 Methods of Measuring Cell Purity for Making Quality Control Determinations and Related Compositions  
This disclosure relates to methods of detecting and quantifying low concentrations of cells in a sample with targeted nanoparticles having Raman reporters using surface-enhanced Raman scattering...
US20180169215 Multivalent Enterovirus Vaccine Compositions and Uses Related Thereto  
This disclosure relates to multivalent enterovirus vaccine compositions and uses related thereto. In certain embodiments, the disclosure relates to vaccine compositions comprising multivalent,...
9999666 Uses of conjugates of GM-CSF and IL-7 to treat viral infections  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20180161000 Systems, Methods and Computer Readable Storage Media Storing Instructions for Generating Planning Images Based on HDR Applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
9994823 Purification of cell mixtures using molecular beacons targeting cell specific RNA  
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular...
9993575 Nanoenhanced hemostatic device and methods for making a layer having hemostatic properties  
Devices and methods relate to inducing or promoting hemostasis. The hemostasis device may include a support layer having a first surface and an opposing second surface. The device may include a...
US20180155439 Compositions and Conjugates Comprising an Interleukin and Polypeptides That Specifically Bind TGF-beta  
This disclosure relates to compositions and conjugates comprising an interleukin, e.g., IL-15 and a polypeptide that specifically binds TGF-beta. Typically the polypeptide that specifically binds...
US20180155430 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
9987356 Anti-CD40 antibodies and methods of administering thereof  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
US20180148755 Oligosaccharide Libraries and Methods of Production  
This disclosure relates to libraries of oligosaccharides comprising multiple individual oligosaccharides derived from cells that contain a tag or detectable marker. In certain embodiments, the tag...
US20180147190 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide Compounds for the Management of CFTR Protein Mediated Diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
US20180147164 2-amino-N'-benzylideneacetohydrazides and Derivatives for the Management of CFTR Protein Mediated Diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
9980936 BH4 antagonists and methods related thereto  
The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
US20180143194 COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCOUS INFECTIONS  
Provided herein are compositions and methods for detecting and/or diagnosing a Staphylococcus aureus (S. aureus) infection in a subject. It is a surprising finding of the present invention that an...
9975868 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20180128833 METHODS OF TREATING WITH TUMOR MEMBRANE VESICLE-BASED IMMUNOTHERAPY AND PREDICTING THERAPEUTIC RESPONSE THERETO  
Disclosed herein is a method for treating a subject having, or at risk of having, a triple negative breast cancer, comprising administering to the subject a therapeutically effective amount of an...
US20180127713 Method of Producing Stem Cell-Derived Endothelial Cells and Uses Thereof  
This disclosure relates to methods of generating endothelial cells derived from stem cells. In certain embodiments, the cells are useful for inducing vasculature in muscles and cardiac tissue. In...
US20180125991 OLIGOSACCHARIDE CONJUGATES FOR TARGETING BACTERIA AND USES RELATED THERETO  
This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria...
US20180125967 HIV Immune Stimulating Compositions Comprising Recombinantly Expressed Pili on Bacteria and Methods Related Thereto  
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant...
US20180125812 Dehydroacetic Acid (DHAA) and Derivative for Uses in Treating Cancer  
This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or other agents that antagonize...
9962423 Protein particles comprising disulfide crosslinkers and uses  
This disclosure relates to particles comprising recombinant proteins, pharmaceutical composition comprising the particles, and therapeutic uses related thereto. In certain embodiments, the...
US20180121600 Methods, Systems and Computer Readable Storage Media for Generating Accurate Nucleotide Sequences  
Methods, systems and computer-readable storage media relate to generating one or more consensus sequences. The methods may include determining a group of one or more reads with each main position...
US20180117145 Immunostimulatory Compositions, Particles, and Uses Related Thereto  
In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition...
US20180116958 NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS  
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
9957300 Virus-like particles, methods of preparation, and immunogenic compositions  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using...
9950168 Methods for intracardiac surgery and intracardiac delivery of therapies and devices  
A method of performing an intracardiac procedure using controlled intermittent diastolic arrest (CIDA) to expand the chambers of the heart to a volume between about 75 to 200% of their normal...
9950146 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20180104243 Tricyclic Amino Containing Compounds for Treatment or Prevention of Symptoms Associated with Endocrine Dysfunction  
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
9944901 Fusion protein for inducing pluripotent stem cells and application method thereof  
Provided is a protein coded by a gene related to cell totipotency and a transcriptional activation domain of a mammalian YAP protein or a fusion protein of a segment with a transcriptional control...
US20180094018 Progesterone Phosphate Analogs and Uses Related Thereto  
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing...
US20180092876 Treating or Preventing Nephrogenic Diabetes Insipidus  
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in...