Patents and Patent Applications from Emory University


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9950168 Methods for intracardiac surgery and intracardiac delivery of therapies and devices  
A method of performing an intracardiac procedure using controlled intermittent diastolic arrest (CIDA) to expand the chambers of the heart to a volume between about 75 to 200% of their normal...
9950146 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20180104243 Tricyclic Amino Containing Compounds for Treatment or Prevention of Symptoms Associated with Endocrine Dysfunction  
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
9944901 Fusion protein for inducing pluripotent stem cells and application method thereof  
Provided is a protein coded by a gene related to cell totipotency and a transcriptional activation domain of a mammalian YAP protein or a fusion protein of a segment with a transcriptional control...
US20180094018 Progesterone Phosphate Analogs and Uses Related Thereto  
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing...
US20180092876 Treating or Preventing Nephrogenic Diabetes Insipidus  
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in...
9932585 Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto  
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of...
9932344 Pyrazolo[1,5-A]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use  
Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (CDK) (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.) are...
9932326 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
9932317 Quinazoline compounds and their use in therapy  
This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in...
9926359 Optogenetic inhibition of overactive neuronal activity  
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain...
9926295 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
9919163 Methods, systems and computer readable storage media for determining optimal respiratory phase for treatment  
Methods, systems and computer-readable storage media relate to determining optimal treatment information. The methods may include determining a dose distribution for one or more target regions by...
US20180066323 Biomarkers in Cancer, Methods, and Systems Related Thereto  
This disclosure relates biomarkers of cancer, e.g. prostate cancer. The biomarkers may be altered expression of nucleic acids, mutations, or proteins encoded therefrom. In certain embodiments, the...
9907797 Combination therapies for overcoming resistance to mitotic agents during chemotherapy  
This disclosure relates to the uses of compounds that target an interaction between CHFR and PARP1. In certain embodiments, the disclosure relate to treating cancer by administering a mitotic...
US20180057817 Particle-Nucleic Acid Conjugates and Therapeutic Uses Related Thereto  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...
US20180057517 Metal Tricarbonyl Complexes Comprising Substituted Iminodiactic Acid Ligands and Uses as Radioisotope Tracers  
This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments,...
9901548 Compositions for encapsulating biomaterials and uses related thereto  
This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments, the disclosure relates to capsules comprising...
US20180052161 BIOMARKERS FOR MALARIA DIAGNOSIS  
Disclosed herein are methods of detecting Plasmodium in a subject (for example, presence of Plasmodium parasite) by detecting the presence and/or amount of one or more metabolites in a sample from...
9895344 Treating various disorders with 7,8-dihydroxyflavone and derivatives thereof  
Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of...
US20180042985 Methods of Improving Behavioral Therapies  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
US20180042956 Glutamate Dehydrogenase 1 Inhibitors and Methods of Treating Cancer  
This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof.
9884815 PGAM1 inhibitors and methods related thereto  
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1...
US20180028357 METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
9877697 Systems, methods and computer readable storage media storing instructions for generating planning images based on HDR applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
9872895 TLR5 ligands, therapeutic methods, and compositions related thereto  
The disclosure relates to antiviral therapeutic methods and related compositions. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection by...
9872834 Nanocarrier therapy for treating invasive tumors  
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
9868728 Quinazoline derivatives, compositions, and uses related thereto  
The invention relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the invention relates to inhibitors of NADPH-oxidase.
US20180009873 FACTOR VIII PROTEINS HAVING ANCESTRAL SEQUENCES, EXPRESSION VECTORS, AND USES RELATED THERETO  
This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more...
9867041 Methods and systems for determining protected location information based on temporal correlations  
The systems and methods can provide location privacy protection by incorporating temporal correlations of a user's locations. The method may include obtaining a first location of a user of a...
9861693 HIV immune stimulating compositions comprising recombinantly expressed pili on bacteria and methods related thereto  
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant...
9861652 2′ Fluoronucleosides  
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and...
9858687 Systems, methods, and computer readable storage media storing instructions for generating an image integrating functional, physiological and anatomical images  
Systems, methods and computer-readable storage mediums relate to generating an image that includes functional, anatomical, and physiological images. The generated image may be an integrated image...
9856534 Selecting use of proteasome inhibitors based on NF-κB2 sequence  
Provided herein are methods for selecting use of proteasome inhibitors.
US20170369417 TAK1 Kinase Inhibitors, Compositions, and Uses Related Thereto  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a...
US20170354747 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
9840693 Polypeptide hydrogels and uses related thereto  
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to...
9833777 Water oxidation catalysts and methods of use thereof  
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred...
US20170343561 DIAGNOSTIC AND THERAPEUTIC METHODS AND PRODUCTS RELATED TO ANXIETY DISORDERS  
The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of...
9827222 Treating or preventing nephrogenic diabetes insipidus  
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in...
US20170334941 2',2'-DIHALO NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER  
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya Ebola and West...
US20170333366 Casein Coated Drug-Loaded Iron Oxide Nanoparticles  
This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising...
9821071 Oligosaccharide conjugates for targeting bacteria and uses related thereto  
This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria...
US20170326256 RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF  
Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor....
US20170322275 Magnetic Resonance Method And Apparatus For Quantitative Simultaneous Multi-Slice Assessment Of Tissue Displacement, Deformation, And Related Biomarker Parameters  
Embodiments relate to a magnetic resonance imaging (MRI) technique in which the two-dimensional (2D) Displacement Encoding with Stimulated Echoes (DENSE) imaging technique and the multiband...
9809616 Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer  
The compounds are of the class of N4-hydroxycytidine nucleosides, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives...
9808464 Compounds and compositions for ossification and methods related thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
US20170313719 Thieno[2,3-D]pyrimidin-4-one Derivatives as NMDAR Modulators and Uses Related Thereto  
The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical...
US20170312283 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
9803197 Particle-nucleic acid conjugates and therapeutic uses related thereto  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...