Patents and Patent Applications from Emory University


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10654910 Factor VIII proteins having ancestral sequences, expression vectors, and uses related thereto  
This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more...
10654902 Methods and compositions for the display of polypeptides on the pili of Gram-positive bacteria  
Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of...
US20200149285 ENERGY-EFFICIENT ASSISTIVE STAIRS  
In a mechanism for recycling energy from stairs (200), a step platform (210) is moveable between an upper and lower position. An energy storage device (220), coupled to the platform (210), stores...
US20200148750 Ebola Virus Antibodies and Binding Agents Derived Therefrom  
This disclosure relates to antibodies and antigen binding fragments that specifically bind Ebola virus particles. In certain embodiments, the antibodies and fragments are capable of treating or...
US20200147081 Use of Kinase Inhibitors to Manage Tuberculosis and Other Infectious Diseases  
This disclosure relates to the use of kinase inhibitor to treat or prevent infectious diseases such as tuberculosis. In certain embodiments, this disclosure relates to treating or preventing an...
10647679 N-methyl-D-aspartate receptor (NMDAR) potentiators, pharmaceutical compositions, and uses related thereto  
This disclosure relates to tetrahydroisoquinolines, salts, and derivatives useful for managing mental or cognitive diseases or conditions of the brain or central nervous system. In certain...
10646580 Oligosaccharide conjugates for targeting bacteria and uses related thereto  
This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria...
US20200138752 2-amino-N'-benzylideneacetohydrazides and Derivatives for the Management of CFTR Protein Mediated Diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
10635705 Methods, systems and computer readable storage media for determining relevant documents based on citation information  
Methods, systems and computer-readable storage media relate to automatically and efficiently determine a set of relevant document(s) relevant to an inputted set of document(s) based on at least...
10633404 Metal tricarbonyl complexes comprising substituted iminodiactic acid ligands and uses as radioisotope tracers  
This disclosure relates to compositions comprising substituted iminodiacetic acid ligands and metal tricarbonyl complexes containing the ligands and derivatives thereof. In certain embodiments,...
10632120 Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction  
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
10632013 Methods and devices for drug delivery to ocular tissue using microneedle  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
10631888 Systems and methods for tissue treatment  
Systems and methods are configured to treat a tissue by automatically linearly oscillating an instrument into a target site. A system may include a body having a length and configured to receive a...
US20200121687 Compounds and Compositions for Ossification and Methods Related Thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
10626378 Respiratory syncytial virus expression vectors  
In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial...
10622099 Systems and methods for supporting hospital discharge decision making  
In one embodiment, a system and method for assisting a physician with a hospital discharge decision pertain to collecting patient data from a patient under consideration who is staying at a...
US20200095608 Methods, Devices and Systems for Enhanced Transduction Efficiency  
The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of...
US20200095583 Methods and Compositions for Managing Vascular Conditions  
This disclosure relates to methods and compositions for managing vascular conditions by targeting microRNA. In certain embodiments, the disclosure relates to antisense, RNA interference, and...
10598170 Methods, devices, and systems for moving a fluid along a fluid path for treatment  
The devices and systems are medical fluid treatment therapies. The device and systems are configured and capable of operating based on small volumes of fluids. The devices and systems include a...
10596145 Heterocyclic flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
10596144 Treating or preventing nephrogenic diabetes insipidus  
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in...
US20200088820 PHASE OFFSET ERROR CORRECTION FOR DISPLACEMENT-ENCODED MR IMAGES  
A system includes acquisition of a plurality of displacement-encoded magnetic resonance (MR) phase images, determination of first pixels associated with one or more image regions of the plurality...
US20200085837 Prostaglandin Receptor EP2 Antagonists, Derivatives, Compositions, and Uses Related Thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
US20200085796 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide Compounds for the Management of CFTR Protein Mediated Diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
US20200085330 Methods and Systems for Automatically Detecting Events Based on ECG Signals Determined From Compressed Sensed Measurements  
Techniques are provided for generating and processing compressed sensor data. Sensor signals can be collected using one or more sensors. The sensor signals can be compressed using a compression...
US20200072831 METHODS OF DETECTING ALLOANTIBODIES TO HLA CLASS II ANTIGENS  
Described herein are materials and methods of incorporating CLIP peptide into the peptide binding groove of HLA Class II antigens and using such HLA Class II antigens for the detection of...
US20200071354 PEPTIDOMIMETICS FOR THE TREATMENT OF NOROVIRUS INFECTION  
The present invention is directed to compounds, compositions and methods for preventing, treating or curing Norovirus infection in human subjects or other animal hosts.
10568889 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
US20200055862 PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE  
Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (CDK) (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.) are...
US20200054623 Chemokine CXCR4 Receptor Modulators and Uses Related Thereto  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. The receptor modulators can be formulated to form pharmaceutical compositions comprising the disclosed...
10561728 Polynucleotides encoding anti-CD40 antibodies  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
10555918 2-amino-N′-benzylideneacetohydrazides and derivatives for the management of CFTR protein mediated diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
10544405 Cas9-nucleic acid complexes and uses related thereto  
This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express...
10544090 Anthraquinone analogs and methods of making and using thereof  
Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings...
10543233 Drug resistant immunotherapy for treatment of a cancer  
The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic...
US20200024230 PGAM1 Inhibitors and Methods Related Thereto  
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1...
10538794 Oligosaccharide libraries and methods of production  
This disclosure relates to libraries of oligosaccharides comprising multiple individual oligosaccharides derived from cells that contain a tag or detectable marker. In certain embodiments, the tag...
10538766 Methods and compositions for managing vascular conditions  
This disclosure relates to methods and compositions for managing vascular conditions by targeting microRNA. In certain embodiments, the disclosure relates to antisense, RNA interference, and...
10537577 Compounds and compositions for ossification and methods related thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
10537574 Use of kinase inhibitors to manage tuberculosis and other infectious diseases  
This disclosure relates to the use of kinase inhibitor to treat or prevent infectious diseases such as tuberculosis. In certain embodiments, this disclosure relates to treating or preventing an...
10537531 Casein coated drug-loaded iron oxide nanoparticles  
This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising...
US20200017433 Modulators of Liver Receptor Homologue 1 (LRH-1) and Uses  
This disclosure relates to modulators of liver receptor homologue 1 (LRH-1) and methods of managing disease and conditions related thereto. In certain embodiments, modulators are derivatives of...
US20200016130 Methods of Diagnosing and Treating Small Cell Lung Cancer Using Polo-Like Kinase 1 (PLK1) Inhibitors  
This disclosure relates to methods of diagnosing and treating small cell lung cancer. In certain embodiments, this disclosure relates to methods of treating small cell lung cancer comprising...
10526303 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20200000764 Dehydroacetic Acid (DHAA) and Derivative for Uses in Treating Cancer  
This disclosure relates to methods of managing or treating cancer with agents that lower circulating acetoacetate levels, such as hypolipidemic agents, or other agents that antagonize...
US20190388592 Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto  
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain...
US20190388549 Targeted Protease Compositions and Uses Related Thereto  
This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the...
10512636 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide compounds for the management of CFTR protein mediated diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...
US20190381042 Tricyclic Amino Containing Compounds for Treatment or Prevention of Symptoms Associated with Endocrine Dysfunction  
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
10506966 Methods and systems for determining sensory motor performance based on non-postural information  
Methods and systems relate to determining sensory motor performance based on user non-postural movements within a generated dynamic virtual environment. The generated environment requires users...