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Patents and Patent Applications from Emory University


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US20140243968 SYSTEMS, DEVICES AND METHODS FOR REPAIR OF HEART VALVE LESIONS  
The systems and devices and methods relate to surgical and percutaneous repair of heart valve regions. The systems and devices are structured to conform to the desired shape of a specific patient....
US20140242068 JAML SPECIFIC BINDING AGENTS, ANTIBODIES, AND USES RELATED THERETO  
Disclosed are specific binding agents such as antibodies and chimera that bind to JAM-like protein. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as...
8815860 Methods for preventing oxidative stress injury of a tissue by a Folate-TEMPOL conjugate  
The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate.
8815835 9-aminonoscapine and its use in treating cancers, including drug-resistant cancers  
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
8815829 3′-azido purine nucleotide prodrugs for treatment of viral infections  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The...
US20140235566 PYRIMIDINE NUCLEOSIDES AND THEIR MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS AND CANCER  
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, cytomegalovirus...
8808225 Methods and devices for drug delivery to ocular tissue using microneedle  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
US20140228240 Screening Blood for Protein Biomarkers and Uses Thereof in Alzheimer's Disease and Mild Cognitive Impairment  
This disclosure is in the area of medical diagnostics that provides a method to assist in diagnosis and monitoring the progression of Alzheimer's disease and mild cognitive impairment (MCI).
US20140221480 METHODS OF MANAGING BRAIN INFLAMMATION  
This disclosure relates to methods of managing brain injury such as inflammation due to trauma induced brain injury and ischemic stroke by administering resatorvid or derivative there of a subject...
US20140220024 CHYMASE COMPOSITIONS, ANTIBODIES, DIAGNOSTICS, AND THERAPEUTIC METHODS RELATED THERETO  
The disclosure relates to chymase, antibodies to chymase, and diagnostic and therapeutic methods relates thereto. It has been discovered that above certain circulating levels of chymase, a patient...
US20140219917 OLIGOSACCHARIDE CONJUGATES FOR TARGETING BACTERIA AND USES RELATED THERETO  
This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria...
8795682 Virus-like particles comprising chimeric human immunodeficiency virus (HIV)/mouse mammary tumor virus (MMTV) envelopes  
Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced...
US20140213924 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR DETERMINING RESPIRATORY INDUCED ORGAN MOTION  
Methods, systems and computer-readable storage media relate to determining respiratory motion from motion data of a target to be treated. The methods may include processing motion data of a target...
US20140212382 PURINE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV,...
8778915 Method for the treatment of central nervous system cancers and compositions related thereto  
Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is...
US20140194422 PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO  
The disclosure relates to piperazine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidase.
US20140193477 COLLAGEN BASED MATERIALS AND USES RELATED THERETO  
This disclosure relates to materials fabricated from collagen and uses relates thereto. Typically, layers of collagen are stretched during a curing period and optionally coated or impregnated with...
8774481 Atlas-assisted synthetic computed tomography using deformable image registration  
Disclosed are systems for and methods of creating a synthetic image by registering a reference or atlas image to a clinical image using both rigid and deformable image registration algorithms. In...
US20140187537 METHODS OF PREDICTING OUTCOMES OF CHEMOTHERAPY TREATMENTS AND ALTERNATIVE THERAPIES  
This disclosure relates to diagnostic and therapeutic methods and systems related thereto. In certain embodiments, the disclosure contemplates methods of improving chemotherapy treatments by...
US20140186949 ENHANCING A POPULATION OF INSULIN RELEASING CELLS USING GFR Alpha-1 Agonists  
Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to...
8765777 Compositions and methods of use for tyrosine kinase inhibitors to treat pathogenic infection  
Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic...
US20140179919 COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT  
The present disclosure relates to organic chemistry and in particular to a series of corticotropin releasing factor type-1 (CRF1) receptor ligand compounds and compositions, as well as methods of...
US20140179750 PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
US20140178374 BAX AGONIST, COMPOSITIONS, AND METHODS RELATED THERETO  
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
US20140178370 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
US20140173261 COMPUTER PROCESSOR WITH INSTRUCTION FOR EXECUTION BASED ON AVAILABLE INSTRUCTION SETS  
A system and method for testing whether a computer processor is capable of executing a requested instruction set. The system includes a computer processor configured to receive an encoded...
US20140163302 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR IMAGE-GUIDED TREATMENT PLANNING AND ASSESSMENT  
Methods, systems and computer-readable storage media relate to image-guided treatment planning and treatment assessment. The methods, systems, and the computer-readable storage medias according to...
US20140163093 METHODS FOR TREATING INFLAMATORY CONDITIONS AND STATES, AND CANCERS BY ANTAGONIZING NF-kB ACTIVATION  
The disclosure is directed to methods for treating inflammatory conditions and cancers that have misregulated NF-κB. In some embodiments, the disclosure is directed to methods for treating ...
8748119 Methods for determining calcineurin activity, and uses in predicting therapeutic outcomes  
One aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test...
8747905 Therapeutic use of CD31 expressing cells  
As described below, the present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.
US20140155643 DIRHODIUM CATALYST COMPOSITIONS AND SYNTHETIC PROCESSES RELATED THERETO  
This disclosure relates to compositions comprising dirhodium catalysts and uses related thereto, e.g., in enantioselective transformations of donor/acceptor carbenoids. In certain embodiments, the...
8741313 Polypeptide vaccine and vaccination strategy against mycobacterium  
A vaccine is provided wherein a polypeptide or combination of peptides from M. tuberculosis is administered to a subject to elicit an immune response. The polypeptide vaccine is administered as...
US20140147411 METHODS OF TREATING CANCER AND TESTING MUTATION ZYGOSITY RELATED THERETO  
In certain embodiments, the disclosure relates to methods of treating cancer comprising administering an effective amount a tyrosine kinase inhibitor in combination with an immunotherapy to a...
8729059 Paramyxovirus family inhibitors and methods of use thereof  
Embodiments of the present disclosure include methods for identifying a compound or compounds useful as therapeutic agents in the treatment of paramyxovirus infections, compounds for the treatment...
US20140135288 SELECTING USE OF PROTEASOME INHIBITORS BASED ON NF-KB2 SEQUENCE  
Provided herein are methods for selecting use of proteasome inhibitors.
8721584 Methods and systems for determining an intravenous insulin infusion rate to correct hyperglycemia of a patient, to maintain euglycemia of a patient, and to prevent hypoglycemia of a patient  
Methods and systems for determining an intravenous infusion rate to correct hyperglycemia of a patient, to maintain euglycemia of a patient, and to prevent hypoglycemia are disclosed. In one...
US20140128683 Sternal Retractor  
Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of...
US20140127314 COMPOSITIONS, USES, AND PREPARATION OF PLATELET LYSATES  
In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium...
US20140127185 METHODS AND COMPOSITIONS USING NEUROPROTECTIVE STEROIDS AND THROMBOLYTIC AGENTS  
Described herein are compositions and methods for treating or preventing ischemic injury. In particular, the methods and compositions relate to the use of a neuroprotective steroid, such as...
8703977 Compounds, intermediates, and methods of preparing the same  
The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds,...
US20140107566 METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
US20140105974 COMPOSITIONS FOR ENCAPSULATING BIOMATERIALS AND USES RELATED THERETO  
This disclosure relates to compositions and methods for encapsulating biomaterials such as cells to prevent immune responses. In certain embodiments the disclosure relates to capsules comprising a...
US20140105931 HEPATITIS C VIRUS PARTICLES, VACCINES, COMPOSITIONS AND METHODS RELATED THERETO  
This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and administered to a subject to illicit...
US20140105828 NANOPARTICLES CARING NUCLEIC ACID CASSETTES FOR EXPRESSING RNA  
This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression...
US20140105826 REDUCED DYE PROBES FOR THE DETECTION OF RADICAL OXYGEN SPECIES  
Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or...
8697846 Methods of making monoclonal antibodies using fusion-peptide epitope adoptive transfer (F-PEAT) technology  
Disclosed are compositions and methods for related to monoclonal antibodies specific for single amino acid variation in an antigen.
8694337 Display of patient-specific data  
Systems, methods, and computer-program products identify clinical data corresponding to a plurality of patients located within a common health care delivery unit, and apply one or more rules to at...
8691777 Combination therapy  
The disclosure relates to methods of treating tuberous sclerosis in a subject, comprising administering a composition comprising an mTOR inhibitor and a tyrosine kinase inhibitor to a subject that...
US20140093497 ANTI-CD40 ANTIBODIES AND USES THEREOF  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
US20140081133 SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE  
According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light...