Patents and Patent Applications from Emory University


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US20160025717 HYPOSIALYLATION DISORDERS  
Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in...
US20160009801 SPECIFIC BINDING AGENTS OF GLYCOPROTEIN IB ALPHA AS SELECTIVE ECTODOMAIN SHEDDING INHIBITORS  
This disclosure relates to specific binding agents, such as isolated recombinant monoclonal antibodies, that bind Glycoprotein Ib alpha (GPIba). More specifically, the disclosure relates to...
US20160008492 COMPOSITIONS OF SACCHARIDE COATED NANOPARTICLES AND USES  
This disclosure relates to nanoparticles of metals, alloys, metal oxides, and multi-metallic oxides comprising oligosaccharide coatings and uses such as in molecular imaging. Typically, the...
US20160008466 PARTICLE COMPOSITIONS AND METHODS RELATED THERETO  
The disclosure relates to metal particles compositions and uses related thereto. In certain embodiments, the disclosure relates to metal particles such as iron particles and their application in...
US20160002174 CXCR4 Antagonists for the Treatment of Medical Disorders  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
US20150374694 TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO  
This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and...
9220682 Nanocarrier therapy for treating invasive tumors  
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
US20150368668 HCV E2 CONSTRUCT COMPOSITIONS AND METHODS  
Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
US20150366933 TREATMENT OF KLEBSIELLA PNEUMONIAE WITH LIPOSOMALLY FORMULATED GLUTATHIONE  
The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as...
US20150359766 METHODS OF TREATING AUTISM WITH mGluR5 ANTAGONISTS  
mGluR5 antagonists are used for the treatment of autism. The human treated by the methods of the invention can also have fragile X syndrome, epilepsy and anxiety.
US20150353905 CAS9-NUCLEIC ACID COMPLEXES AND USES RELATED THERETO  
This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express...
US20150352190 Modified Factor VIII  
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
9205085 Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction  
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
US20150347680 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA FOR ANALYZING A SAMPLE  
Methods, systems, and computer readable storage media relate to processing and analyzing a sample to determine presence or concentration of at least one sensor target in a sample. A method of...
US20150335765 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
US20150335685 ENGINEERED STEM CELL THERAPY FOR CARDIAC REPAIR  
This disclosure relates to compositions and methods of cardiac repair. In certain embodiments, the disclosure relates to a composition comprised of peptide amphiphiles and cardiac and/or cardiac...
US20150329912 BIOMARKERS IN CANCER, METHODS, AND SYSTEMS RELATED THERETO  
This disclosure relates biomarkers of cancer, e.g. prostate cancer. The biomarkers may be altered expression of nucleic acids, mutations, or proteins encoded therefrom. In certain embodiments, the...
9181227 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
9180138 2′-fluoronucleosides  
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and...
US20150315129 PROCESSES FOR FORMING AMIDE BONDS AND COMPOSITIONS RELATED THERETO  
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an...
US20150313571 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR GENERATING PLANNING IMAGES BASED ON HDR APPLICATORS  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
US20150307840 ENDOTHELIAL AND ENDOTHELIAL LIKE CELLS PRODUCED FROM FIBROBLASTS AND USES RELATED THERETO  
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the disclosure relates to methods of...
US20150306082 SOLENOPSIN AND DERIVATIVES, THERAPEUTIC COMPOSITIONS, AND METHODS RELATED THERETO  
This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto. In certain embodiments, the disclosure relates to compounds of the following...
US20150298100 PHOTOCATALYTIC POLYOXOMETALATE COMPOSITIONS OF TUNGSTOVANADATES AND USES AS WATER OXIDATION CATALYSTS  
This disclosure relates to photocatalytic polyoxometalate compositions of tungstovanadates and uses as water oxidation catalysts. In certain embodiments, the disclosure relates to compositions...
US20150274692 7,8-DIHYDOXYFLAVONE AND 7,8-SUBSTITUTED FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20150266929 VIRUS-LIKE PARTICLES, METHODS OF PREPARATION, AND IMMUNOGENIC COMPOSITIONS  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using...
US20150265778 TARGETING THERAPEUTIC AGENTS  
Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration...
9142030 Systems, methods and computer readable storage media storing instructions for automatically segmenting images of a region of interest  
Systems, methods, and computer-readable storage media relate to segmenting an image series of at least one image of a region of interest of a subject. The methods, systems, and computer readable...
9138472 CD40L vaccines, compositions, and methods related thereto  
The disclosure relates to vaccinating a subject against a viral infection, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the use of CD40L expressed...
9138228 Vascular conduit device and system for implanting  
The present invention provides a vascular conduit device including a deformable flange and complementary securing ring in cooperation for securing the device within an aperture defined in a tissue...
US20150259649 CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO  
This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered...
9133441 Enhancing a population of insulin releasing cells using GFR α-1 agonists  
Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to...
US20150252096 SELF-ASSEMBLING COLLAGEN-LIKE POLYPEPTIDE SEQUENCES FOR APPLICATIONS AND USES RELATED THERETO  
This disclosure relates to collagen like polypeptides, applications, and uses related thereto. In certain embodiments, the disclosure relates to collagen like polypeptides wherein hydroxy proline...
US20150250793 BAX AGONIST, COMPOSITIONS, AND METHODS RELATED THERETO  
To compare sensitivities of the compounds, A549 human lung cancer cells were treated with increasing concentrations (0, 1, 5, 10, 25 μM) of 2-(2-Nitro-fluoren-9-ylidenemethyl)-phenol (CYD-1-87)...
D738193 Accessory mount  
US20150239972 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20150238593 MVA EXPRESSING MODIFIED HIV ENVELOPE, GAG AND POL GENES  
The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
US20150232558 STIMULATING BONE FORMATION BY INHIBITION OF CD28 CO-STIMULATION  
The disclosure relates to methods of growing bone or increasing bone mineral density and/or volume comprising administering an effective amount of a therapeutic containing abatacept or belatacept...
US20150231410 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA FOR DETERMINING OPTIMAL RESPIRATORY PHASE FOR TREATMENT  
Methods, systems and computer-readable storage media relate to determining optimal treatment information. The methods may include determining a dose distribution for one or more target regions by...
US20150231228 HIV IMMUNE STIMULATING COMPOSITIONS COMPRISING RECOMBINANTLY EXPRESSED PILI ON BACTERIA AND METHODS RELATED THERETO  
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant...
US20150231227 COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE  
Novel plasmid constructs useful for the delivery of DNA vaccines are provided having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding...
9107696 Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus  
A method of embryo transfer (“ET”) that improves fertility rates by eliminating transferred air during the procedure is provided. Also provided is a method for hormonally enhancing the uterine...
9102727 Human anti-PD-1 antibodies and uses therefor  
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing,...
US20150216906 POLYPEPTIDE HYDROGELS AND USES RELATED THERETO  
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to...
US20150209180 Apparatus and Methods for Drug Delivery Using Microneedles  
A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication...
9089574 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
US20150206302 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR INTEGRATING FLUOROSCOPY VENOGRAM AND MYOCARDIAL IMAGES  
Systems, methods, and computer-readable storage media relate to generate an integrated image including fluoroscopy venogram and myocardial image with left-ventricular (LV) contraction sequence and...
US20150203442 Anthraquinone Analogs and Methods of Making and Using Thereof  
Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings...
US20150196540 NMDA RECEPTOR MODULATORS AND USES RELATED THERETO  
This disclosure relates to NMDA modulators and used related thereto such as for treatment of central nervous system disorders. In certain embodiments, compounds disclosed herein are NR2C...
9079852 NMDA receptor antagonists for neuroprotection  
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain...