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US20120029932 |
DISPLAY OF PATIENT-SPECIFIC DATA
Systems, methods, and computer-program products identify clinical data corresponding to a plurality of patients located within a common health care delivery unit, and apply one or more rules to at...
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US20120028977 |
Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions
Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive...
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US20120027666 |
POLYOXOMETALATE WATER OXIDATION CATALYSTS AND METHODS OF USE THEREOF
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment,...
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US20120022086 |
CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS
Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a...
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US20120022070 |
Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and...
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8101718 |
Methods of administering porcine B-domainless fVIII
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
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US20110319416 |
Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions
Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive...
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8080659 |
CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
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US20110306579 |
METHODS OF NEUROPROTECTION USING NEUROPROTECTIVE STEROIDS AND A VITAMIN D
Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective...
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US20110305636 |
COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT
Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein,...
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8071795 |
HIF inhibitors
HIF-1 inhibitors and methods of use thereof are provided.
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US20110294844 |
9-AMINONOSCAPINE AND ITS USE IN TREATING CANCERS, INCLUDING DRUG-RESISTANT CANCERS
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
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8067537 |
Composition and method for treatment of stomatitis
A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a...
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8067424 |
Selective inhibitors for cyclin-dependent kinases
This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from...
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US20110288044 |
Modulation of sodium channels by nicotinamide adenine dinucleotide
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the...
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US20110286919 |
CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs),...
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US20110282587 |
COMPUTER READABLE STORAGE MEDIUMS, METHODS AND SYSTEMS FOR NORMALIZING CHEMICAL PROFILES IN BIOLOGICAL OR MEDICAL SAMPLES DETECTED BY MASS SPECTROMETRY
Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass...
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US20110282081 |
Methods of Preparing 1-Deoxy-Sphingoid Bases and Derivatives Thereof
Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes...
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US20110281908 |
Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer...
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US20110275839 |
COMPOUNDS, INTERMEDIATES, AND METHODS OF PREPARING THE SAME
The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds,...
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US20110274651 |
Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition
Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are...
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US20110263553 |
STEROID ANALOGUES FOR NEUROPROTECTION
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
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US20110262354 |
CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
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8034579 |
Proteins with enhanced functionality and methods of making novel proteins using circular permutation
The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel...
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8032335 |
Evaluating magnetic resonance spectra
Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various...
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US20110235884 |
Atlas-Assisted Synthetic Computed Tomography Using Deformable Image Registration
Disclosed are systems for and methods of creating a synthetic image by registering a reference or atlas image to a clinical image using both rigid and deformable image registration algorithms. In...
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US20110230361 |
PROSTATE CANCER BIOMARKERS TO PREDICT RECURRENCE AND METASTATIC POTENTIAL
Described herein are methods for predicting the recurrence, progression, and metastatic potential of a prostate cancer in a subject. For example, the method comprises detecting in a sample from a...
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US20110224752 |
MICROELECTRODE STIMULATION FOR TREATMENT OF EPILEPSY OR OTHER NEUROLOGIC DISORDER
Methods for treating a neurologic disorder by neurostimulation. The stimulation may be applied using electromagnetic energy. In certain embodiments, distributed electrical stimulation is applied to...
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US20110224181 |
METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
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8008312 |
CXCR4 antagonists for the treatment of HIV infection
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry...
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US20110206699 |
Methods for the Treatment of Graft-Versus-Host Disease
Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and...
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8003324 |
Modulation of sodium channels by nicotinamide adenine dinucleotide
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the...
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US20110191866 |
METHODS OF MAKING MONOCLONAL ANTIBODIES USING FUSION-PEPTIDE EPITOPE ADOPTIVE TRANSFER (F-PEAT) TECHNOLOGY
Disclosed are compositions and methods for related to monoclonal antibodies specific for single amino acid variation in an antigen.
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US20110189236 |
Methods and Compositions for the Display of Polypeptides on the Pili of Gram-Positive Bacteria
Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of...
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7989649 |
Tumor imaging compounds
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB) ...
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7972311 |
Cardioplegia catheter system
A cardioplegia catheter system for delivery of a cardioplegia solution, comprising a cardioplegia catheter comprising an elongate tubular catheter body that defines a continuous central lumen and a...
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US20110152692 |
SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE
According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light...
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US20110144196 |
TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF
Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of...
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US20110144096 |
TREATING VARIOUS DISORDERS USING TRKB AGONISTS
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
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7960589 |
Synthesis of sphingosines and their derivatives
Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like.
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US20110129496 |
Use of mTOR Inhibitors to Enhance T Cell Immune Responses
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
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US20110105343 |
Systems Biology Approach Predicts Immunogenicity of Vaccines
A major challenge in vaccinology is to prospectively determine vaccine efficacy. Disclosed herein are methods and compositions for identifying early expression “signatures” that predicted imm...
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US20110088309 |
DEVICE FOR CAPTURING INSECTS
In one aspect, a device for capturing at least one living subject is disclosed. In one embodiment, the device has a housing means with a body portion defined between a first end and a second end...
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US20110085974 |
SMALL MOLECULE LIGAND-DRUG CONJUGATES FOR TARGETED CANCER THERAPY
The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof....
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7918814 |
Method for drug delivery to ocular tissue using microneedle
Methods and devices are provided for administering a drug to a patient's eye. The methods include (a) inserting a hollow microneedle into the sclera or corneal stroma without penetrating across the...
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US20110077293 |
GAMBOGIC AMINE, A SELECTIVE TrkA AGONIST WITH NEUROPROTECTIVE ACTIVITY
Small molecule agonists, partial agonists, and antagonists for the TrkA receptor are described. The compounds are gambogic amines, where the carboxylic acid group of gambogic acid (CO2H) has been...
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7915244 |
Methods for the treatment of a traumatic central nervous injury
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
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US20110070166 |
REDUCED DYE PROBES FOR THE DETECTION OF RADICAL OXYGEN SPECIES
Reduced dyes, such as hydrocyanines, deuterocyanines, and/or other deuterated dyes capable of detecting one or more reactive oxygen species are described herein. The reduced dyes exhibit little or...
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US20110064675 |
ELEMENTAL IRON NANOPARTICLES
Synthesis of iron nanoparticles with a substantially unoxidized iron core and a biocompatible coating is described. The nanoparticles are formed by reacting an iron salt solution with a reducing...
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US20110064656 |
Methods of Determining Renal Function using Technetium-99m Tricarbonyl-nitrilotriacetic acid
This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracer 99mTc(CO)3(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure...
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