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US20130123618 |
Imaging Agents
This invention provides amino acid derivatives useful in detecting and evaluating brain and body tumors, including (1S,2S) anti-2-[18F]FACPC and (1R,2R) anti-2-[18F]FACPC.
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US20130123185 |
METHODS OF TREATING AND DIAGNOSING ACUTE CHEST SYNDROME
In certain embodiments, the disclosure relates to methods of treating or preventing organ inflammation or failure such as pulmonary inflammation comprising administering a heme scavenger such as...
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US20130122514 |
METHODS FOR DETERMINATION OF PROTEIN PHOSPHATASE ACTIVITY, AND USES IN PREDICTING THERAPEUTIC OUTCOMES
One aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test...
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US20130116275 |
INHIBITORS OF HIF AND ANGIOGENESIS
Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for example...
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8435979 |
Use of imipramine blue and analogs thereof in treating cancers
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions...
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8435972 |
Method for the treatment of central nervous system cancers and compositions related thereto
Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is...
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8435923 |
Compositions, materials incorporating the compositions, and methods of using the compositions and materials
Compositions, materials incorporating the compositions, and methods of use thereof, for the protection and/or decontamination of contaminants are disclosed.
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8435493 |
Imaging agents
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
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US20130109628 |
MICRORNA COMPOSITIONS AND METHODS RELATED THERETO
The disclosure relates to microRNAs (miRNAs) for the prophylaxis and/or treatment of neoplasia. The disclosure relates in particular to sequence corresponding to miR2 and the miR-548 family,...
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8432095 |
Process for fabricating metal bus lines for OLED lighting panels
Systems and methods for the design and fabrication of OLEDs, including high-performance large-area OLEDs, are provided. Variously described fabrication processes may be used to deposit and pattern...
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8430836 |
Conduit device and system for implanting a conduit device in a tissue wall
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
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8426398 |
Conjugates of noscapine and folic acid and their use in treating cancer
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs),...
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US20130095042 |
SILICA-BASED NANOPARTICLES AND METHODS OF STIMULATING BONE FORMATION AND SUPPRESSING BONE RESORPTION THROUGH MODULATION OF NF-KB
Osteoporosis, is an exceedingly common malady that leads to bone fracture and results from an imbalance in the rate of osteoblastic bone formation with respect to osteoclastic bone degradation....
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8420680 |
NMDA receptor antagonists for neuroprotection
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain...
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8420354 |
Methods to manufacture 1,3-dioxolane nucleosides
This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (−)-DAPD, suitable for large scale development, is described. In...
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US20130085383 |
SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR IMAGE-GUIDED THERAPIES
Systems, methods, and computer-readable storage media relate to providing image guidance that can improve the accuracy of interventional procedures, such biopsy sampling, for example, by accurately...
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US20130073054 |
TISSUE SUPPORT STRUCTURE
An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second...
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US20130070440 |
OLED Light Panel in Combination with a Gobo
A first device is provided. The first device may include a first light source comprising one or more organic light emitting devices and a gobo that is optically coupled to the first light source....
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US20130065267 |
CONJUGATES AND METHODS FOR MEASURING CHAPERONE-MEDIATED AUTOPHAGY
This disclosure relates to methods of detecting chaperone-mediated autophagy. In some embodiments, the disclosure relates to methods of measuring chaperone-mediated autophagy in living cells and in...
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US20130064807 |
USE OF THROMBIN MUTANTS TO INHIBIT THE ANTICOAGULATION EFFECT OF THROMBIN INHIBITORS
The present disclosure provides methods for inhibiting the anticoagulation effect of a thrombin inhibitor in a patient in need thereof comprising administration of a therapeutically effective...
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8394957 |
9-aminonoscapine and its use in treating cancers, including drug-resistant cancers
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
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8394760 |
Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a...
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US20130059314 |
FRET-BASED METHOD FOR THE DETERMINATION OF PROTEIN PHOSPHATASE AND KINASE ACTIVITY
This disclosure relates to methods of determining activities of protein phosphatases and kinases. The disclosure further relates to methods of clinical monitoring of calcineurin activity and...
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US20130045203 |
Uses of Noscapine and Derivatives in Subjects Diagnosed with FAP
This disclosure relates to methods of treating or preventing cancer comprising administering a pharmaceutical composition comprising noscapine or noscapine derivatives to a subject diagnosed with a...
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US20130040947 |
TRKB AGONISTS AND METHODS OF USE
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-di-hydroxyflavone derivative with modified flavone or heterocyclic ring to...
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US20130037827 |
OLED LIGHT PANEL WITH CONTROLLED BRIGHTNESS VARIATION
Embodiments may provide a light source with a controlled brightness variation. A first device is provided that includes a substrate and a plurality of OLEDs disposed on the substrate. Each of the...
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US20130034552 |
TEMPERATURE SENSITIVE CONJUGATE COMPOSITIONS, AND USES RELATED THERETO
This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature...
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US20130030523 |
ANNULOPLASTY RINGS AND METHODS FOR HEART VALVE REPAIR
An annuloplasty ring, configured for implantation in the annulus of a heart valve, comprising multiple segments each of which are geometrically shaped from a three dimensional perspective to...
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US20130005837 |
CANCER BIOMARKERS TO PREDICT RECURRENCE AND METASTATIC POTENTIAL
Described herein are methods for predicting recurrence, progression, and metastatic potential of a prostate cancer in a subject. In certain embodiments, the methods comprise analyzing a sample from...
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US20130005656 |
Modified Factor VIII
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
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8343131 |
Catheter for modified perfusion
A catheter adapted for use in passing fluids and medicines therethrough for use in the perfusion or reperfusion of blood or blood-fluid mixtures into the arteries, veins, tissues, conduits, or...
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US20120328568 |
COMPOSITIONS AND USES OF LECTINS
The disclosure relates to uses of a purified or isolated lectin to kill bacteria, viruses, and other pathogens. In certain embodiments, the disclosure relates to method of treating or preventing an...
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US20120322895 |
BIODEGRADABLE POLYMERIC NETWORKS AND METHODS FOR MANUFACTURING THE SAME
Methods of manufacturing a three-dimensional, biodegradable, thermoset polymeric network composition having desirable degradation and mechanical properties, comprising a macromer component...
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US20120322144 |
MICROFLUIDIC DEVICES AND SYSTEMS
A device may be configured to allow manipulation of the cell(s), such as test or drug applications, independent of the operation and/or structure of the device. The device may be configured to...
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US20120302575 |
Methods for Preventing Oxidative Stress Injury of a Tissue by a Folate-Tempol Conjugate.
The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal is-chemia-reperfusion by a Folate-TEMPOL conjugate.
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US20120302565 |
KINASE INHIBITORS FOR PREVENTING OR TREATING PATHOGEN INFECTION AND METHOD OF USE THEREOF
The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to...
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US20120294803 |
CXCR4 ANTAGONISTS FOR IMAGING OF CANCER AND INFLAMMATORY DISORDERS
The invention provides radiolabeled CXCR4 antagonists, compositions and methods of use for imaging of chemokine CXCR4 receptors and biological conditions associated with the expression of CXCR4...
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US20120294503 |
SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIUMS STORING INSTRUCTIONS FOR APPLYING MULTISCALE BILATERAL FILTERING TO MAGNETIC RESONANCE (RI) IMAGES
Systems, methods and computer-readable storage mediums relate to segmenting MR images using multiscale bilateral filtering. Before the multiscale bilateral filtering, the MR images are transformed...
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US20120289491 |
METHODS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM INJURY VIA A TAPERED ADMINISTRATION PROTOCOL
The present invention provides methods for the treatment or the prevention of neuronal damage in the CNS. Specifically, the methods of the invention provide for the administration of a...
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US20120277222 |
TREATING VARIOUS DISORDERS USING TRKB AGONISTS
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
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US20120277178 |
COMPOSITIONS AND METHODS FOR TREATING FRAGILE X PREMUTATION RVGG REPEATS-MEDIATED TOXICITY
Compositions and methods of treatment or prophylaxis of fragile-X associated disorders are provided, as well as methods of screening compounds and kits to screen a library of compounds.
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US20120270788 |
Method of Administering Porcine B-Domainless fVIII
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
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US20120264592 |
COMPOSITIONS, MATERIALS INCORPORATING THE COMPOSITIONS, AND METHODS OF USING THE COMPOSITIONS AND MATERIALS
The invention relates to composition and methods of using described compositions as oxidative catalysis. In certain embodiments, the invention relates to a composition having a nitrogen oxide...
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US20120264217 |
RESPIRATORY SYNCYTIAL VIRUS EXPRESSION VECTORS
In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial...
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US20120251537 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using...
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US20120245133 |
METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
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8268809 |
Kinase inhibitors for preventing or treating pathogen infection and method of use thereof
The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to...
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US20120231015 |
FRAGILE X MENTAL RETARDATION PROTEIN (FMRP), COMPOSITIONS, AND METHODS RELATED THERETO
The invention relates to fragile X mental retardation protein (FMKP), compositions, and methods related thereto. In certain embodiments, the invention relates to treating a neurological disorder by...
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US20120226260 |
METHODS AND DEVICES FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
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8252846 |
Strategies for delivery of active agents using micelles and particles
The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present...
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