Patents and Patent Applications from Emory University


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US20180355039 METHODS OF REDUCING LIVER PD-1-EXPRESSING CD8+ T CELLS USING PD-1 FC FUSION PROTEINS THAT BIND FC RECEPTORS  
The present invention relates to methods of reducing liver PD-1-expressing CD8+ T cells using PD-1 Fc fusion proteins that bind Fc receptors, as well as diagnostic, prognostic, therapeutic methods...
10149859 Nucleotide and nucleoside therapeutic compositions and uses related thereto  
This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside...
10149672 Devices and methods for stabilizing tissue  
The devices and methods relate to devices for stabilizing and/or positioning tissue (e.g., heart) within a surgical area. The device may include an articulating arm and a tissue stabilizing...
US20180346445 Pyrazoline Dihydroquinolones, Pharmaceutical Compositions, and Uses  
This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are...
US20180344877 RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF  
Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor....
US20180344845 ANTI-CD40 ANTIBODIES AND USES THEREOF  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
US20180343938 Anti-Fog Ventilating Face Masks  
Ventilating face masks and methods and systems for face mask ventilation are disclosed. In some embodiments, a mask ventilation system can comprise an expandable base layer comprising side edges...
US20180340942 Methods of Culturing and Characterizing Antibody Secreting Cells  
This disclosure relates to methods of culturing and characterizing antibody secreting cells. In certain embodiments, this disclosure relates to methods of isolating antibody secreting cells, e.g.,...
10137208 Vivo tumor targeting and spectroscopic detection with surface-enhanced raman nanoparticle tags  
Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the...
US20180333477 CHIMERIC RSV, IMMUNOGENIC COMPOSITIONS, AND METHODS OF USE  
This disclosure relates to chimeric respiratory syncytial virus (RSV), live attenuated vaccine and immunogenic compositions, and methods of use. In certain embodiments, the chimeric respiratory...
US20180326009 Glial Cell Line Derived Neurotrophic Factor, Obesity, and Obesity-Related Diseases and Conditions  
The disclosure relates to therapeutic methods for regulating weight gain, metabolic syndrome, and insulin resistance. In certain embodiments, the disclosure relates to methods of treating or...
US20180322247 Systems, Methods and Computer Readable Storage Media for Analyzing a Sample  
Methods, systems, and computer readable storage media relate to processing and analyzing a sample to determine presence or concentration of at least one sensor target in a sample. A method of...
US20180318818 Redox Dehydration Coupling Catalysts and Methods Related Thereto  
This disclosure relates to synthetic coupling methods using catalytic molecules. In certain embodiments, the catalytic molecules comprise heterocyclic thiolamide, S-acylthiosalicylamide,...
US20180318350 Immune Cells with DNMT3A Gene Modifications and Methods Related Thereto  
This disclosure relates to the genetic modification of DNMT3A gene in immune cells. In certain embodiments, the modified immune cells may be used in adoptive T cells therapies to enhance immune...
US20180318315 Prostaglandin Receptor EP2 Antagonists, Derivatives, Compositions, and Uses Related Thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
US20180311268 RESPONSE-GUIDED HCV THERAPY  
The present disclosure relates to solid dosage forms comprising anti-HCV compounds and methods of using such dosage forms to treat or prevent HCV infection. Direct-acting antiviral agents (DAAs)...
US20180298057 Compositions and Methods for Managing Respiratory Conditions  
This disclosure relates to compositions for use in managing respiratory distress and related disorders. In certain embodiments, the disclosure relates to methods of treating or preventing...
US20180296635 Protein Particles Comprising Disulfide Crosslinkers and Uses Related Thereto  
This disclosure relates to particles comprising recombinant proteins, pharmaceutical composition comprising the particles, and therapeutic uses related thereto. In certain embodiments, the...
US20180289799 Conjugates of GM-CSF and IL-7, and Compositions Thereof  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20180289664 BENZHYDROL DERIVATIVES FOR THE MANAGEMENT OF CONDITIONS RELATED TO HYPOXIA INDUCIBLE FACTORS  
This disclosure relates to benzhydrol derivatives for managing conditions related to the Hypoxia Inducible Factor (HIF) pathway such as uses in treating cancer. In certain embodiment, the...
10093709 GM-CSF and IL-4 conjugates, compositions, and methods related thereto  
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g.,...
10093609 TAK1 kinase inhibitors, compositions, and uses related thereto  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a...
10092282 Sternal retractor  
Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of...
US20180280342 Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
US20180273540 PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE  
Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (CDK) (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.) are...
10081678 Specific binding antibodies of glycoprotein IB alpha as selective ectodomain shedding inhibitors  
This disclosure relates to specific binding agents, such as isolated recombinant monoclonal antibodies, that bind Glycoprotein Ib alpha (GPIba). More specifically, the disclosure relates to...
US20180265581 JAML Specific Binding Agents, Antibodies, and Uses Related Thereto  
Certain embodiments of the disclosure relate to targeted binding agents that specifically bind to JAM-like protein and therein inhibit epithelial damage. Although it is not intended that...
10072058 Chimeric virus-like particles incorporating fusion GPI anchored GM-CSF and IL-4 conjugates  
This disclosure relates to a GM-CSF and IL-4 conjugate fused to a glycolipid (GPI)-anchoring sequence that is incorporated into chimeric virus-like particles (VLPs) enriched with a viral protein,...
US20180250337 GENETICALLY ENGINEERED DRUG RESISTANT T CELLS AND METHODS OF USING THE SAME  
The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.
US20180250299 Use of Kinase Inhibitors to Manage Tuberculosis and Other Infectious Diseases  
This disclosure relates to the use of kinase inhibitor to treat or prevent infectious diseases such as tuberculosis. In certain embodiments, this disclosure relates to treating or preventing an...
US20180244623 N-methyl-D-aspartate Receptor (NMDAR) Potentiators, Pharmaceutical Compositions, And Uses Related Thereto  
This disclosure relates to tetrahydroisoquinolines, salts, and derivatives useful for managing mental or cognitive diseases or conditions of the brain or central nervous system. In certain...
10058624 Recombinant promoters and vectors for protein expression in liver and use thereof  
Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor....
10058584 Methods of improving behavioral therapies  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
US20180237491 Optogenetic Inhibition of Overactive Neuronal Activity  
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain...
10054653 Magnetic resonance method and apparatus for quantitative simultaneous multi-slice assessment of tissue displacement, deformation, and related biomarker parameters  
Embodiments relate to a magnetic resonance imaging (MRI) technique in which the two-dimensional (2D) Displacement Encoding with Stimulated Echoes (DENSE) imaging technique and the multiband...
10052381 Classifiers of NF-κB pathway activation, devices, and methods of use thereof  
This disclosure relates to classifiers of NF-κB pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in...
10052362 Glial cell line derived neurotrophic factor, obesity, and obesity-related diseases and conditions  
The disclosure relates to therapeutic methods for regulating weight gain, metabolic syndrome, and insulin resistance. In certain embodiments, the disclosure relates to methods of treating or...
10052332 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
US20180228924 Methylsulfonamide Derivatives and Uses Related Thereto  
This disclosure relates to methylsulfonamide derivatives and uses as imaging agents and other uses related to CXCR4 inhibition. In certain embodiments, the disclosure relates to pharmaceutical...
10045989 Quinazoline derivatives, compositions, and uses related thereto  
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or...
US20180221390 Steroid Analogues for Neuroprotection  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
10041945 Methods of diagnosing and treating tuberculosis  
This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of CD4+ cells. In certain embodiments,...
10040783 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
10034931 Use of EGFR pathway inhibitors to increase immune responses to antigens  
This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In...
US20180207166 Compounds and Compositions for Ossification and Methods Related Thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
10030053 Immunogenic compositions and methods of use thereof  
Embodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host. Embodiments of the compositions encompass proteins derived from the...
US20180200492 CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
10023842 Endothelial and endothelial like cells produced from fibroblasts and uses related thereto  
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the disclosure relates to methods of...
10022378 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
US20180193404 COMPOSITION FOR TREATMENT OF RSV  
This invention relates to a composition, the use of a composition for treatment, and a method of treatment of infection with Respiratory syncytial virus (RSV). The composition for treatment is a...