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Patents and Patent Applications from Emory University


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8871268 Biodegradable polymeric networks and methods for manufacturing the same  
Methods of manufacturing a three-dimensional, biodegradable, thermoset polymeric network composition having desirable degradation and mechanical properties, comprising a macromer component...
US20140309280 ASSAYS FOR MICRO-RNA-182 AS A BIOMARKER FOR MUSCLE ATROPHY AND THERAPEUTIC APPLICATIONS  
In certain embodiments, this disclosure relates to assays for miR-182 and therapeutic applications. In certain embodiments, the disclosure relates to methods of evaluating a state of skeletal...
8859595 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
8858489 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20140294818 PGAM1 INHIBITORS AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1...
US20140294764 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO  
This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered...
8846624 Modified protein polymers  
In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the...
US20140288013 METHODS AND COMPOSITIONS FOR THE MANAGEMENT OF CANCER USING 2-DG AND AN IGF-IR INHIBITOR  
The disclosure relates to methods and compositions for the management of cancer. In certain embodiments, the disclosure relates to methods of treating or preventing cancer by administering an...
8841317 Noscapine and analogs and methods related thereto  
The invention relates to the innate immune pathway and anti-inflammatory molecules with therapeutic properties. In some embodiments, the invention relates to compounds and pharmaceutical...
8841276 Fulvene and fulvalene analogs and their use in treating cancers  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and...
8840899 Use of mTOR inhibitors to enhance T cell immune responses  
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
US20140271615 HYPOSIALYLATION DISORDERS  
Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in a...
US20140270447 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR AUTOMATICALLY SEGMENTING IMAGES OF A REGION OF INTEREST  
Systems, methods, and computer-readable storage media relate to segmenting an image series of at least one image of a region of interest of a subject. The methods, systems, and computer readable...
US20140261099 SURGICAL SUPPORT DEVICE  
A surgical support device can provide members for attaching various medical accessories in a safe, stable and secure manner. The surgical support device can also configured to isolate the sterile...
8834841 Imaging agents  
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
US20140257215 EXTENDED WEAR DEVICES FOR LIQUID DEODORIZERS AND CONTAINERS INCLUDING SUCH DEVICES  
A device and container, including the device, are configured for deodorizing an effluent, e.g., bodily waste. The device can include a carrier configured to retain a deodorizer fluid and disperse...
US20140256033 DEVICES FOR DETERMINING CELL FORCE PROPERTIES AND METHODS OF MANUFACTURING THE DEVICES  
A device may be configured to allow individual measuring of at least one property of at least one cell, such as measuring a contraction force of a platelet. The device may include a plurality of...
US20140255927 RNA SPLICING ALTERATIONS AND U1 SMALL NUCLEAR RIBONUCLEOPROTEINS IN NEURODEGENERATIVE DISEASES  
This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or RNA or RNA expression profiles in a subject. In...
US20140255517 MANAGING POST-TRAUMATIC STRESS DISORDER  
In certain embodiments, the disclosure relates to methods of treating or preventing posttraumatic stress disorder comprising administering a pharmaceutical composition comprising effective amount...
US20140255441 VLPS CONTAINING LIGANDS AND METHODS RELATED THERETO  
This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a TLR5...
US20140255426 WNT PATHWAY INHIBITORS FOR TREATING VIRAL INFECTIONS  
In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection comprising administering an effective amount of a Wnt pathway inhibitor optionally in...
8827719 Resuscitation manikins and methods of using the same  
Cardiopulmonary resuscitation (CPR) training manikins and methods of using CPR training manikins are described.
US20140249199 TAK1 KINASE INHIBITORS, COMPOSITIONS, AND USED RELATED THERETO  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a...
US20140248372 BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO  
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair and methods related thereto. In certain...
8822462 Subunit selective NMDA receptor potentiators for the treatment of neurological conditions  
Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive...
8822367 Polyoxometalate water oxidation catalysts and methods of use thereof  
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment,...
8821135 Devices and systems for medical fluid treatment  
The devices and systems are medical fluid treatment therapies. The device and systems are configured and capable of operating based on small volumes of fluids. The devices and systems include a...
US20140243968 SYSTEMS, DEVICES AND METHODS FOR REPAIR OF HEART VALVE LESIONS  
The systems and devices and methods relate to surgical and percutaneous repair of heart valve regions. The systems and devices are structured to conform to the desired shape of a specific patient....
US20140242068 JAML SPECIFIC BINDING AGENTS, ANTIBODIES, AND USES RELATED THERETO  
Disclosed are specific binding agents such as antibodies and chimera that bind to JAM-like protein. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as...
8815860 Methods for preventing oxidative stress injury of a tissue by a Folate-TEMPOL conjugate  
The present disclosure is generally related to methods of preventing oxidative stress injury induced by renal ischemia-reperfusion by a Folate-TEMPOL conjugate.
8815835 9-aminonoscapine and its use in treating cancers, including drug-resistant cancers  
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
8815829 3′-azido purine nucleotide prodrugs for treatment of viral infections  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The...
US20140235566 PYRIMIDINE NUCLEOSIDES AND THEIR MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS AND CANCER  
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, cytomegalovirus...
8808225 Methods and devices for drug delivery to ocular tissue using microneedle  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
US20140228240 Screening Blood for Protein Biomarkers and Uses Thereof in Alzheimer's Disease and Mild Cognitive Impairment  
This disclosure is in the area of medical diagnostics that provides a method to assist in diagnosis and monitoring the progression of Alzheimer's disease and mild cognitive impairment (MCI).
US20140221480 METHODS OF MANAGING BRAIN INFLAMMATION  
This disclosure relates to methods of managing brain injury such as inflammation due to trauma induced brain injury and ischemic stroke by administering resatorvid or derivative there of a subject...
US20140220024 CHYMASE COMPOSITIONS, ANTIBODIES, DIAGNOSTICS, AND THERAPEUTIC METHODS RELATED THERETO  
The disclosure relates to chymase, antibodies to chymase, and diagnostic and therapeutic methods relates thereto. It has been discovered that above certain circulating levels of chymase, a patient...
US20140219917 OLIGOSACCHARIDE CONJUGATES FOR TARGETING BACTERIA AND USES RELATED THERETO  
This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria...
8795682 Virus-like particles comprising chimeric human immunodeficiency virus (HIV)/mouse mammary tumor virus (MMTV) envelopes  
Embodiments of the present disclosure encompasses virus-like particles, methods of making virus-like particles, including expression vectors, wherein the virus-like particles may comprise enhanced...
US20140213924 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR DETERMINING RESPIRATORY INDUCED ORGAN MOTION  
Methods, systems and computer-readable storage media relate to determining respiratory motion from motion data of a target to be treated. The methods may include processing motion data of a target...
US20140212382 PURINE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF VIRAL INFECTIONS  
The present invention is directed to compounds, compositions and methods for treating or preventing viral infections using nucleoside analog monophosphate prodrugs. More specifically, HCV,...
8778915 Method for the treatment of central nervous system cancers and compositions related thereto  
Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is...
US20140194422 PIPERAZINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO  
The disclosure relates to piperazine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidase.
US20140193477 COLLAGEN BASED MATERIALS AND USES RELATED THERETO  
This disclosure relates to materials fabricated from collagen and uses relates thereto. Typically, layers of collagen are stretched during a curing period and optionally coated or impregnated with...
8774481 Atlas-assisted synthetic computed tomography using deformable image registration  
Disclosed are systems for and methods of creating a synthetic image by registering a reference or atlas image to a clinical image using both rigid and deformable image registration algorithms. In...
US20140187537 METHODS OF PREDICTING OUTCOMES OF CHEMOTHERAPY TREATMENTS AND ALTERNATIVE THERAPIES  
This disclosure relates to diagnostic and therapeutic methods and systems related thereto. In certain embodiments, the disclosure contemplates methods of improving chemotherapy treatments by...
US20140186949 ENHANCING A POPULATION OF INSULIN RELEASING CELLS USING GFR Alpha-1 Agonists  
Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to...
8765777 Compositions and methods of use for tyrosine kinase inhibitors to treat pathogenic infection  
Compositions and methods are provided for using tyrosine kinase inhibitors to treat pathogenic infection. In particular, methods for using Abl-family tyrosine kinase inhibitors to treat pathogenic...
US20140179919 COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT  
The present disclosure relates to organic chemistry and in particular to a series of corticotropin releasing factor type-1 (CRF1) receptor ligand compounds and compositions, as well as methods of...
US20140179750 PROSTAGLANDIN RECEPTOR EP2 ANTAGONISTS, DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...