Patents and Patent Applications from Emory University


Match Document Document Title
US20180289799 Conjugates of GM-CSF and IL-7, and Compositions Thereof  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20180289664 BENZHYDROL DERIVATIVES FOR THE MANAGEMENT OF CONDITIONS RELATED TO HYPOXIA INDUCIBLE FACTORS  
This disclosure relates to benzhydrol derivatives for managing conditions related to the Hypoxia Inducible Factor (HIF) pathway such as uses in treating cancer. In certain embodiment, the...
10093709 GM-CSF and IL-4 conjugates, compositions, and methods related thereto  
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g.,...
10093609 TAK1 kinase inhibitors, compositions, and uses related thereto  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a...
10092282 Sternal retractor  
Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of...
US20180280342 Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
US20180273540 PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE  
Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (CDK) (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9, CDK10, CDK11, CDK12, CDK13, etc.) are...
10081678 Specific binding antibodies of glycoprotein IB alpha as selective ectodomain shedding inhibitors  
This disclosure relates to specific binding agents, such as isolated recombinant monoclonal antibodies, that bind Glycoprotein Ib alpha (GPIba). More specifically, the disclosure relates to...
US20180265581 JAML Specific Binding Agents, Antibodies, and Uses Related Thereto  
Certain embodiments of the disclosure relate to targeted binding agents that specifically bind to JAM-like protein and therein inhibit epithelial damage. Although it is not intended that...
10072058 Chimeric virus-like particles incorporating fusion GPI anchored GM-CSF and IL-4 conjugates  
This disclosure relates to a GM-CSF and IL-4 conjugate fused to a glycolipid (GPI)-anchoring sequence that is incorporated into chimeric virus-like particles (VLPs) enriched with a viral protein,...
US20180250337 GENETICALLY ENGINEERED DRUG RESISTANT T CELLS AND METHODS OF USING THE SAME  
The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.
US20180250299 Use of Kinase Inhibitors to Manage Tuberculosis and Other Infectious Diseases  
This disclosure relates to the use of kinase inhibitor to treat or prevent infectious diseases such as tuberculosis. In certain embodiments, this disclosure relates to treating or preventing an...
US20180244623 N-methyl-D-aspartate Receptor (NMDAR) Potentiators, Pharmaceutical Compositions, And Uses Related Thereto  
This disclosure relates to tetrahydroisoquinolines, salts, and derivatives useful for managing mental or cognitive diseases or conditions of the brain or central nervous system. In certain...
10058624 Recombinant promoters and vectors for protein expression in liver and use thereof  
Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor....
10058584 Methods of improving behavioral therapies  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
US20180237491 Optogenetic Inhibition of Overactive Neuronal Activity  
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain...
10054653 Magnetic resonance method and apparatus for quantitative simultaneous multi-slice assessment of tissue displacement, deformation, and related biomarker parameters  
Embodiments relate to a magnetic resonance imaging (MRI) technique in which the two-dimensional (2D) Displacement Encoding with Stimulated Echoes (DENSE) imaging technique and the multiband...
10052381 Classifiers of NF-κB pathway activation, devices, and methods of use thereof  
This disclosure relates to classifiers of NF-κB pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in...
10052362 Glial cell line derived neurotrophic factor, obesity, and obesity-related diseases and conditions  
The disclosure relates to therapeutic methods for regulating weight gain, metabolic syndrome, and insulin resistance. In certain embodiments, the disclosure relates to methods of treating or...
10052332 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
US20180228924 Methylsulfonamide Derivatives and Uses Related Thereto  
This disclosure relates to methylsulfonamide derivatives and uses as imaging agents and other uses related to CXCR4 inhibition. In certain embodiments, the disclosure relates to pharmaceutical...
10045989 Quinazoline derivatives, compositions, and uses related thereto  
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or...
US20180221390 Steroid Analogues for Neuroprotection  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
10041945 Methods of diagnosing and treating tuberculosis  
This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of CD4+ cells. In certain embodiments,...
10040783 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
10034931 Use of EGFR pathway inhibitors to increase immune responses to antigens  
This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In...
US20180207166 Compounds and Compositions for Ossification and Methods Related Thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
10030053 Immunogenic compositions and methods of use thereof  
Embodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host. Embodiments of the compositions encompass proteins derived from the...
US20180200492 CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
10023842 Endothelial and endothelial like cells produced from fibroblasts and uses related thereto  
This disclosure relates to endothelial or endothelial like cells cultured from fibroblasts exposed to transcription factor ETV2. In certain embodiments, the disclosure relates to methods of...
10022378 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
US20180193404 COMPOSITION FOR TREATMENT OF RSV  
This invention relates to a composition, the use of a composition for treatment, and a method of treatment of infection with Respiratory syncytial virus (RSV). The composition for treatment is a...
10016408 Chemokine CXCR4 receptor modulators and uses related thereto  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
US20180186762 7,8-DIHYDOXYFLAVONE AND 7,8-SUBSTITUTED FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20180185372 USE OF TREM-1 INHIBITORS FOR TREATMENT, ELIMINATION AND ERADICATION OF HIV-1 INFECTION  
Compounds, compositions, and methods of treatment and prevention of HIV, including HIV-1 and HIV-2, Dengue, and Chikungunya infection are disclosed. The compounds are TREM-1 inhibitors....
10011656 Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor  
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing,...
10011629 Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer  
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile...
10010526 Heterocyclic flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
US20180179495 Growth and Survival Compositions for Cells Capable of Producing Antibodies and Methods Related Thereto  
This disclosure relates to growth media and environments for in vitro culturing of cells that produce or are capable of producing antibodies. In certain embodiments, the media comprises IL-6,...
US20180171287 Methods of Measuring Cell Purity for Making Quality Control Determinations and Related Compositions  
This disclosure relates to methods of detecting and quantifying low concentrations of cells in a sample with targeted nanoparticles having Raman reporters using surface-enhanced Raman scattering...
US20180169215 Multivalent Enterovirus Vaccine Compositions and Uses Related Thereto  
This disclosure relates to multivalent enterovirus vaccine compositions and uses related thereto. In certain embodiments, the disclosure relates to vaccine compositions comprising multivalent,...
9999666 Uses of conjugates of GM-CSF and IL-7 to treat viral infections  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20180161000 Systems, Methods and Computer Readable Storage Media Storing Instructions for Generating Planning Images Based on HDR Applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
9994823 Purification of cell mixtures using molecular beacons targeting cell specific RNA  
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular...
9993575 Nanoenhanced hemostatic device and methods for making a layer having hemostatic properties  
Devices and methods relate to inducing or promoting hemostasis. The hemostasis device may include a support layer having a first surface and an opposing second surface. The device may include a...
US20180155439 Compositions and Conjugates Comprising an Interleukin and Polypeptides That Specifically Bind TGF-beta  
This disclosure relates to compositions and conjugates comprising an interleukin, e.g., IL-15 and a polypeptide that specifically binds TGF-beta. Typically the polypeptide that specifically binds...
US20180155430 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
9987356 Anti-CD40 antibodies and methods of administering thereof  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
US20180148755 Oligosaccharide Libraries and Methods of Production  
This disclosure relates to libraries of oligosaccharides comprising multiple individual oligosaccharides derived from cells that contain a tag or detectable marker. In certain embodiments, the tag...
US20180147190 3-(phenyl)-N-(4-phenoxybenzyl)-1,2,4-oxadiazole-5-carboxamide Compounds for the Management of CFTR Protein Mediated Diseases  
This disclosure relates to methods of treating or preventing cystic fibrosis transmembrane conductance regulator (CFTR) mediated diseases such as cystic fibrosis, chronic obstructive pulmonary...