Patents and Patent Applications from Emory University


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9545403 Chemokine CXCR4 receptor modulators and uses related thereto  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
US20170008947 Expression of Chimeric Polypeptide with Variable Lymphocyte Receptors on Immune Cells and Uses for Treating Cancer  
This disclosure relates to recombinant cellular expression of chimeric proteins with peptide sequences derived from lymphocyte receptors and uses for treating cancer. In certain embodiments, the...
US20170007652 Botanical Extracts and Compounds from Schinus Plants and Methods of Use  
This disclosure relates to extracts from the Anacardiaceae (cashew plant family) and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the...
9539082 Tissue support structure  
An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second...
US20170002326 Purification of Cell Mixtures Using Molecular Beacons Targeting Cell Specific RNA  
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular...
US20170000841 TREATMENT OF KLEBSIELLA PNEUMONIAE WITH LIPOSOMALLY FORMULATED GLUTATHIONE  
The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as...
US20170000818 NYLON-3 POLYMERS ACTIVE AGAINST CLOSTRIDIUM DIFFICILE  
A method and corresponding composition to inhibit outgrowth of C. difficile spores and/or to inhibit growth of C. difficile vegetative cells in a mammal in which an amount of a nylon-3 polymer or...
US20170000801 TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
US20170000508 Devices and Methods for Stabilizing Tissue  
The devices and methods relate to devices for stabilizing and/or positioning tissue (e.g., heart) within a surgical area. The device may include an articulating arm and a tissue stabilizing...
US20160375074 Botanical Extracts and Compounds from Castanea Plants and Methods of Use  
This disclosure relates to extracts from chestnut plants and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the leaves of a Castanea...
9527881 Steroid analogues for neuroprotection  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
US20160369344 Detecting MicroRNA and Iso-MicroRNA to Evaluate Vascular and Cardiac Health  
This disclosure relates to diagnosing or evaluating the state of vascular or cardiac health of a subject by detecting alterations in the microRNA and/or iso-microRNA profile contained in a sample...
US20160368897 Pyrazoline Dihydroquinolones, Pharmaceutical Compositions, and Uses  
This disclosure relates to pyrazoline dihydroquinolone derivates, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are useful...
US20160367516 Treating or Preventing Nephrogenic Diabetes Insipidus  
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in...
US20160362492 METHODS AND COMPOSITIONS FOR THE TREATMENT OF PERSISTENT INFECTIONS AND CANCER BY INHIBITING THE PROGRAMMED CELL DEATH 1 (PD-1) PATHWAY  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
US20160362410 PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIAMINE COMPOUNDS AS CDK INHIBITORS AND THEIR THERAPEUTIC USE  
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds...
US20160361470 Bone Morphogenetic Protein Pathway Activation, Compositions for Ossification, and Methods Related Thereto  
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair and methods related thereto. In certain...
9518044 Prostaglandin receptor EP2 antagonists, derivatives, compositions, and uses related thereto  
The present invention is directed to compounds of Formula IC: wherein the substituents are described herein. These compounds and their pharmaceutically acceptable salts thereof are prostaglandin...
9512184 Hepatitis C virus particles, vaccines, compositions and methods related thereto  
This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and administered to a subject to illicit...
9511071 Compounds and compositions for ossification and methods related thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
9510948 Systems, devices and methods for repair of heart valve lesions  
The systems and devices and methods relate to surgical and percutaneous repair of heart valve regions. The systems and devices are structured to conform to the desired shape of a specific patient....
US20160348077 FUSION PROTEIN FOR INDUCING PLURIPOTENT STEM CELLS AND APPLICATION METHOD THEREOF  
Provided is a protein coded by a gene related to cell totipotency and a transcriptional activation domain of a mammalian YAP protein or a fusion protein of a segment with a transcriptional control...
9504674 TrkB agonists and methods of use  
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-dihydroxyflavone derivative with modified flavone or heterocyclic ring to...
US20160340437 Methods for Managing Sepsis  
This disclosure relates to methods of treating or preventing sepsis, severe sepsis, or septic shock comprising administering an effective amount of a 2B4 antibody, a CD48 variant, a CD48 antibody...
9499489 Myxovirus therapeutics, compounds, and uses related thereto  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the...
US20160335257 Methods, Systems and Computer Readable Storage Media for Determining Relevant Documents Based On Citation Information  
Methods, systems and computer-readable storage media relate to automatically and efficiently determine a set of relevant document(s) relevant to an inputted set of document(s) based on at least...
9493742 Purification of cell mixtures using molecular beacons targeting cell specific RNA  
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular...
US20160327573 Methods for Diagnosing Onset and Monitoring Progression of Huntington's Disease  
The present invention relates to methods of diagnosing onset, monitoring progression and initiating therapies for a neurological disorder, such as juvenile- or adult-onset Huntington's disease, by...
US20160324834 Use of mTOR Inhibitors to Enhance T Cell Immune Responses  
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
9486643 Methods, systems and computer readable storage media storing instructions for image-guided treatment planning and assessment  
Methods, systems and computer-readable storage media relate to image-guided treatment planning and treatment assessment. The methods, systems, and the computer-readable storage medias according to...
US20160318985 Chimeric Virus-Like Particles Incorporating Fusion GPI Anchored GM-CSF and IL-4 Conjugates  
This disclosure relates to a GM-CSF and IL-4 conjugate fused to a glycolipid (GPI)-anchoring sequence that is incorporated into chimeric virus-like particles (VLPs) enriched with a viral protein,...
US20160317793 CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20160317474 Managing Visual Dysfunction or Loss of Vision for Diabetic Subjects  
This disclosure relates to managing diabetes induced visual dysfunctions or vision loss by altering levels of dopamine. In certain embodiments, the disclosure relates to methods of treating or...
US20160317473 METHODS OF TREATING OR PREVENTING BRAIN DAMAGE DUE TO HYPOXIC-ISCHEMIA  
This disclosure relates to managing brain injury. In certain embodiments, this disclosure relates to methods comprising administering an effective amount of an inhibitor of sphingosine-1-phoshate...
US20160310608 Targeted Protease Compositions and Uses Related Thereto  
This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the...
US20160310604 SMALL MOLECULE LIGAND-DRUG CONJUGATES FOR TARGETED CANCER THERAPY  
The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof....
US20160310511 Myxovirus Therapeutics, Compounds, and Uses Related Thereto  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the...
US20160310417 Formulations and Methods For Targeted Ocular Delivery of Therapeutic Agents  
Formulations, systems, and methods of administration are provided for preferential targeted delivery of drug to ocular tissue. In embodiments, the formulation may include a non-Newtonian fluid...
US20160304567 METHODS AND COMPOSITIONS FOR THE DISPLAY OF POLYPEPTIDES ON THE PILI OF GRAM- POSITIVE BACTERIA  
Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of...
9469685 Antibodies directed against influenza  
Antibodies or antibody fragments, wherein the antibody or the fragment binds HA domain of influenza virus (e.g. H1N1, H5N1, or both). Also described are cloned human antibodies that bind influenza.
9458458 Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto  
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of...
9458226 Recombinant antibodies against H1N1 influenza  
Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice challenged with a lethal dose of swine...
9458217 Methods of managing graft versus host disease  
This disclosure relates to the use of drugs to prevent graft versus host disease (GVHD) in a subject after, before, or during a hematopoietic stem cell transplant. In certain embodiments, the...
9458131 Compounds and compositions used to epigenetically transform cells and methods related thereto  
This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered...
9457080 Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1) pathway  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
9453239 Recombinant MVA viruses expressing clade A/G, clade B, and clade C modified HIV env, gag and pol genes  
The invention provides modified vaccinia Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
9451882 Integrated system and methods for real-time anatomical guidance in a diagnostic or therapeutic procedure  
According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light...
US20160250326 Conjugates of GM-CSF and IL-7, and Compositions Thereof  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
9428815 HIV-1 reverse transcriptase codon deletion and its use in the management and treatment of HIV infections  
The present invention provides an isolated HIV-1 mutant and isolated nucleic acid molecules comprising HIV-RT coding sequences harboring a novel mutation in the S68 codon, and in particular,...
9428478 Piperazine derivatives, compositions, and uses related thereto  
The disclosure relates to piperazine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidase.