Patents and Patent Applications from Emory University


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US20170173306 SPITTABLE NEEDLE  
Splittable needles for use in catheterizations are described. The splittable needles are formed of equal or unequal longitudinal parts that precisely align and lock for secure access to subject's...
9683020 VLPS containing ligands and methods related thereto  
This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a...
9682948 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20170166569 Asparagine Endopeptidase (AEP) Inhibitors for Managing Cancer and Compositions Related Thereto  
This disclosure relates to asparagine endopeptidase inhibitors for managing cancer and compositions related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are substituted...
US20170165225 Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
9676727 Myxovirus therapeutics, compounds, and uses related thereto  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the...
US20170160182 ROTATABLE PLATFORM DEVICES AND SYSTEMS  
The devices can improve rotational movement substantially without or with significant reduction in mechanical interference. The devices can be configured to independently rotate a module about two...
US20170157178 Cellular Compositions Used To Restore Stem Cell or Progenitor Cell Function and Methods Related Thereto  
This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered...
9673030 Computer readable storage mediums, methods and systems for normalizing chemical profiles in biological or medical samples detected by mass spectrometry  
Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass...
9669092 Antagonism of the VIP signaling pathway  
Inhibition of the VIP signaling pathway using VIP antagonists is contemplated. Methods of treating or preventing a viral infection comprising administering a VIP antagonist to a subject in need...
9662332 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
9662208 Devices and methods for surgical and percutaneous repair of heart valve lesions  
The devices and methods relate to surgical and percutaneous repair of heart valve regions. The devices may be structured to conform to the desired shape of a specific patient. The devices may...
US20170146520 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
9657076 GM-CSF and IL-4 conjugates, compositions, and methods related thereto  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-4 and uses related thereto, e.g., enhancing the immune system. Typically the GM-CSF and IL-4 are connected by...
9655765 Extended wear devices for liquid deodorizers and containers including such devices  
A device and container, including the device, are configured for deodorizing an effluent, e.g., bodily waste. The device can include a carrier configured to retain a deodorizer fluid and disperse...
US20170137785 Polypeptide Hydrogels and Uses Related Thereto  
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to...
US20170137401 Chemokine CXCR4 and CCR5 Receptor Modulators and Uses Related Thereto  
The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
9649508 Methods, systems and computer readable storage media storing instructions for determining patient specific treatment planning margins  
Methods, systems and computer-readable storage media relate to determining individualized treatment planning margins. The methods may include processing motion data of a target obtained from at...
US20170119857 Method of Administering Porcine B-Domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20170118634 Methods and Systems for Determining Protected Location Information Based on Temporal Correlations  
The systems and methods can provide location privacy protection by incorporating temporal correlations of a user's locations. The method may include obtaining a first location of a user of a...
US20170114400 Polynucleotide Based Movement, Kits and Methods Related Thereto  
This disclosure relates DNA based movement of objects. In certain embodiments, particles, pairs of particles, or a rods are conjugated with single stranded DNA that hybridizes to a single stranded...
9629543 Internet-based cognitive diagnostics using visual paired comparison task  
Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for...
US20170107489 Therapeutic Use of CD31 Expressing Cells  
The present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.
US20170106359 WATER OXIDATION CATALYSTS AND METHODS OF USE THEREOF  
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred...
US20170100477 Methods of Immunizing a Subject and Compositions Related Thereto  
This disclosure relates to methods of immunization comprising administering an effective amount of an immunogenic composition comprising an antigen or vaccine and an adjuvant disclosed herein to a...
US20170100283 Tissue Support Structure  
An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second...
9618522 Diagnostic testing in dementia and methods related thereto  
This disclosure relates to diagnostic testing for subjects with or at risk of dementia and methods related thereto. In certain embodiments, the disclosure relates to methods of diagnosing a...
9616070 Use of GABAA receptor antagonists for the treatment of excessive sleepiness and disorders associated with excessive sleepiness  
GABAA receptor mediated hypersomnia can be treated by administering a GABAA receptor antagonist (e.g., flumazenil; clarithromycin; picrotoxin; bicuculline; cicutoxin; and oenanthotoxin). In some...
9605083 JAML specific binding agents, antibodies, and uses related thereto  
Disclosed are specific binding agents such as antibodies and chimera that bind to JAM-like protein. Also disclosed are heavy chain fragments, light chain fragments, and CDRs of the antibodies, as...
US20170082623 Methods of Diagnosing and Treating Tuberculosis  
This disclosure relates to methods of treating and diagnosing a tuberculosis infection as pulmonary active or latent based on biomarkers expressed on pools of CD4+ cells. In certain embodiments,...
US20170081385 Variable Lymphocyte Receptors (VLR) Modifications and Compositions and Uses Related Thereto  
This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and...
US20170081314 Prostaglandin Receptor EP2 Antagonists, Derivatives, Compositions, and Uses Related Thereto  
The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or...
US20170079971 CHEMOKINE CXCR4 RECEPTOR MODULATORS AND USES RELATED THERETO  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
US20170079950 Methods of Managing Graft Versus Host Disease (GvHD) Using Indole Carboxyaldehydes or Derivatives Thereof  
In certain embodiments, this disclosure relates to methods of treating or preventing HvGD comprising administering an effective amount of indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or...
US20170079864 Surgical Support Devices and Systems  
These systems and devices can be placed on top of any commercially available standard operating table and therefore can provide a portable and inexpensive alternative to commercially available...
9600881 Methods, systems and computer readable storage media storing instructions for imaging and determining information associated with regions of the brain  
Methods, systems and computer-readable storage mediums relate to imaging techniques of a region, for example, the brain, with magnetization transfer contrast (MTC°) effects with less specific...
9598491 Methods for the treatment of infections and tumors  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20170076052 METHODS AND SYSTEMS FOR DYNAMIC MANAGEMENT OF A HEALTH CONDITION  
Methods and systems relate to dynamic management of a health condition based on the changing needs and status of individual patient(s) and/or provider(s). The method may include processing...
US20170073387 Compositions of GM-CSF and Interleukin Fusions for Immune Modulation and Uses Related Thereto  
This disclosure relates to recombinant proteins comprising a GM-CSF sequence and an interleukin sequence and nucleic acids related thereto. In certain embodiments, the disclosure relates to...
US20170071896 BH4 Antagonists and Methods Related Thereto  
The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
9593125 Heterocyclic flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
9592226 Solenopsin and derivatives, therapeutic compositions; and methods related thereto  
This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto. In certain embodiments, the disclosure relates to compounds of the following...
US20170065615 Steroid Analogues for Neuroprotection  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
9585915 Polypeptide hydrogels and uses related thereto  
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to...
US20170051284 Manipulating MicroRNA for the Management of Neurological Diseases or Conditions and Compositions Related Thereto  
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of...
US20170049909 COMPOSITIONS FOR THE INACTIVATION OF VIRUS REPLICATION AND METHODS OF MAKING AND USING THE SAME  
Provided herein are recombinant constructs, vectors and expression cassettes including a first promoter which is suitably a tRNA promoter operably connected to a first polynucleotide encoding a...
US20170049815 Selective Chemotherapy Treatments and Diagnostic Methods Related Thereto  
This disclosure relates to methods of identifying subjects that have an increased likelihood of responding to a combination of a poly (ADP) ribose polymerase enzyme inhibitor and a platinum based...
US20170049468 Systems and Methods for Tissue Treatment  
Systems and methods are configured to treat a tissue by automatically linearly oscillating an instrument into a target site. A system may include a body having a length and configured to receive a...
9572864 Compositions and uses of lectins  
The disclosure relates to uses of a purified or isolated lectin to kill bacteria, viruses, and other pathogens. In certain embodiments, the disclosure relates to method of treating or preventing...
9572561 Sternal retractor  
Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of...