Patents and Patent Applications from Emory University


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US20170260575 Devices and Methods Useful for Detecting Mechanical Forces of Ligand Receptor Interactions  
This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting...
US20170258904 Antagonism of the VIP Signaling Pathway  
Inhibition of the VIP signaling pathway with VIP antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising...
9758809 RNA splicing alterations and U1 small nuclear ribonucleoproteins in neurodegenerative diseases  
This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or RNA or RNA expression profiles in a subject. In...
9758794 HCV E2 construct compositions and methods  
Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
US20170252411 Compositions Derived from Platelet Lysates and Uses in Vascularization  
This disclosure relates to compositions comprising a fibrin polymer produced by mixing platelet lysates with a minimal essential medium and thrombin. Typically, an optimized concentration of a...
9751825 TAK1 kinase inhibitors, compositions, and used related thereto  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a...
9743905 Systems, methods and computer readable storage media storing instructions for generating planning images based on HDR applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
9737880 Photocatalytic polyoxometalate compositions of tungstovanadates and uses as water oxidation catalysts  
This disclosure relates to photocatalytic polyoxometalate compositions of tungstovanadates and uses as water oxidation catalysts. In certain embodiments, the disclosure relates to compositions...
9737522 NMDA receptor modulators and uses related thereto  
This disclosure relates to NMDA modulators and used related thereto such as for treatment of central nervous system disorders. In certain embodiments, compounds disclosed herein are NR2C...
9737492 Casein coated drug-loaded iron oxide nanoparticles  
This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising...
US20170233428 NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER  
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile...
US20170231522 Magnetic Resonance Method And Apparatus For Quantitative Time-Resolved Assessment Of Tissue Displacement And Related Biomarker Parameters With Blood Suppression In The Whole Cardiac Cycle  
Embodiments relate to acquiring magnetic resonance (MR) images with suppressed residual blood signal in the early cardiac phases, leading to images with a preferred dark-blood appearance...
US20170226173 GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto  
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g.,...
US20170224322 Sternal Retractor  
Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of...
9725499 Self-assembling collagen-like polypeptide sequences for applications and uses related thereto  
This disclosure relates to collagen like polypeptides, applications, and uses related thereto. In certain embodiments, the disclosure relates to collagen like polypeptides wherein hydroxy proline...
9724412 Chymase compositions, antibodies, diagnostics, and therapeutic methods related thereto  
The disclosure relates to chymase, antibodies to chymase, and diagnostic and therapeutic methods relates thereto. It has been discovered that above certain circulating levels of chymase, a patient...
US20170216561 Delivery Devices, Systems and Methods for Delivering Therapeutic Materials  
Delivery devices, systems, and methods may be configured to define a barrier region at a treatment site to deliver one or more therapeutic materials. A device for delivering one or more...
US20170216319 Treating Various Disorders Using TrkB Agonists  
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
US20170209572 Classifiers of NF-kB Pathway Activation, Devices, and Methods of Use Thereof  
This disclosure relates to classifiers of NF-κB pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in...
US20170198303 Methods, Devices and Systems for Enhanced Transduction Efficiency  
The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of...
US20170196885 USE OF GABAA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EXCESSIVE SLEEPINESS AND DISORDERS ASSOCIATED WITH EXCESSIVE SLEEPINESS  
GABAA receptor mediated hypersomnia can be treated by administering a GABAA receptor antagonist (e.g., flumazenil; clarithromycin; picrotoxin; bicuculline; cicutoxin; and oenanthotoxin). In some...
9700881 Heterocyclic coupling catalysts and methods related thereto  
This disclosure relates to synthetic coupling methods using a catalytic molecule comprising two bonded atoms wherein one atom is an amide nitrogen and the second atom is not nitrogen or carbon,...
9688959 Compositions, uses, and preparation of platelet lysates  
In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium...
US20170173306 SPITTABLE NEEDLE  
Splittable needles for use in catheterizations are described. The splittable needles are formed of equal or unequal longitudinal parts that precisely align and lock for secure access to subject's...
9683020 VLPS containing ligands and methods related thereto  
This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a...
9682948 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, compositions, and methods related thereto  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20170166569 Asparagine Endopeptidase (AEP) Inhibitors for Managing Cancer and Compositions Related Thereto  
This disclosure relates to asparagine endopeptidase inhibitors for managing cancer and compositions related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are substituted...
US20170165225 Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
9676727 Myxovirus therapeutics, compounds, and uses related thereto  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the...
US20170160182 ROTATABLE PLATFORM DEVICES AND SYSTEMS  
The devices can improve rotational movement substantially without or with significant reduction in mechanical interference. The devices can be configured to independently rotate a module about two...
US20170157178 Cellular Compositions Used To Restore Stem Cell or Progenitor Cell Function and Methods Related Thereto  
This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered...
9673030 Computer readable storage mediums, methods and systems for normalizing chemical profiles in biological or medical samples detected by mass spectrometry  
Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass...
9669092 Antagonism of the VIP signaling pathway  
Inhibition of the VIP signaling pathway using VIP antagonists is contemplated. Methods of treating or preventing a viral infection comprising administering a VIP antagonist to a subject in need...
9662332 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
9662208 Devices and methods for surgical and percutaneous repair of heart valve lesions  
The devices and methods relate to surgical and percutaneous repair of heart valve regions. The devices may be structured to conform to the desired shape of a specific patient. The devices may...
US20170146520 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
9657076 GM-CSF and IL-4 conjugates, compositions, and methods related thereto  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-4 and uses related thereto, e.g., enhancing the immune system. Typically the GM-CSF and IL-4 are connected by...
9655765 Extended wear devices for liquid deodorizers and containers including such devices  
A device and container, including the device, are configured for deodorizing an effluent, e.g., bodily waste. The device can include a carrier configured to retain a deodorizer fluid and disperse...
US20170137785 Polypeptide Hydrogels and Uses Related Thereto  
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to...
US20170137401 Chemokine CXCR4 and CCR5 Receptor Modulators and Uses Related Thereto  
The disclosure relates to chemokine receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
9649508 Methods, systems and computer readable storage media storing instructions for determining patient specific treatment planning margins  
Methods, systems and computer-readable storage media relate to determining individualized treatment planning margins. The methods may include processing motion data of a target obtained from at...
US20170119857 Method of Administering Porcine B-Domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20170118634 Methods and Systems for Determining Protected Location Information Based on Temporal Correlations  
The systems and methods can provide location privacy protection by incorporating temporal correlations of a user's locations. The method may include obtaining a first location of a user of a...
US20170114400 Polynucleotide Based Movement, Kits and Methods Related Thereto  
This disclosure relates DNA based movement of objects. In certain embodiments, particles, pairs of particles, or a rods are conjugated with single stranded DNA that hybridizes to a single stranded...
9629543 Internet-based cognitive diagnostics using visual paired comparison task  
Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for...
US20170107489 Therapeutic Use of CD31 Expressing Cells  
The present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.
US20170106359 WATER OXIDATION CATALYSTS AND METHODS OF USE THEREOF  
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred...
US20170100477 Methods of Immunizing a Subject and Compositions Related Thereto  
This disclosure relates to methods of immunization comprising administering an effective amount of an immunogenic composition comprising an antigen or vaccine and an adjuvant disclosed herein to a...
US20170100283 Tissue Support Structure  
An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second...
9618522 Diagnostic testing in dementia and methods related thereto  
This disclosure relates to diagnostic testing for subjects with or at risk of dementia and methods related thereto. In certain embodiments, the disclosure relates to methods of diagnosing a...