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US20120130282 |
TARGETING THERAPEUTIC AGENTS
Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration...
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US20120123205 |
ADDITIONAL SYSTEMS AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DISGNOSTIC OR THERAPEUTIC PROCEDURE
A system and method for intra-operatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In embodiments, the system includes multiple light sources configured...
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US20120108650 |
MICRO RNA MARKERS AND METHODS RELATED THERETO
The present invention provides methods of diagnosis of Alzheimer's disease including assessing the levels of certain microRNAs in a subject and comparing these to levels in subjects not exhibiting...
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US20120108510 |
METHODS OF IMPROVING BEHAVIORAL THERAPIES
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
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US20120107902 |
Processes For Forming Amide Bonds And Compositions Related Thereto
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an...
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8168583 |
2-fluoronucleosides
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and c...
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US20120083713 |
DEVICE FOR GAUGING A FORCE THRESHOLD AND ENGAGING A TARGET OF INTEREST
The disclosure generally relates to devices and instruments for engaging a target of interest, having a resilient member for gauging a force threshold. The device or instrument may include a tip...
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8147512 |
Dual closing guide for a surgical instrument
A hand-operated surgical instrument with sequentially engaged tip closing guides. The instrument includes first and second arms having tips that close during a closure operation. A slotted tip...
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US20120076820 |
CD40L VACCINES, COMPOSITIONS, AND METHODS RELATED THERETO
The disclosure relates to vaccinating a subject against a viral infection, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the use of CD40L expressed on...
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US20120071539 |
COMPOUNDS AND METHODS FOR MODULATING THE SILENCING OF A POLYNUCLEOTIDE OF INTEREST
Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an...
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US20120059282 |
INTERNET-BASED COGNITIVE DIAGNOSTICS USING VISUAL PAIRED COMPARISON TASK
Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for...
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US20120058978 |
METHOD FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM CANCERS AND COMPOSITIONS RELATED THERETO
Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is...
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US20120053199 |
NOSCAPINE AND ANALOGS AND METHODS RELATED THERETO
The invention relates to the innate immune pathway and anti-inflammatory molecules with therapeutic properties. In some embodiments, the invention relates to compounds and pharmaceutical...
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US20120052115 |
NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
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US20120052058 |
METHODS OF MANAGING THE BLOOD COAGULATION AND PHARMACEUTICAL COMPOSITIONS RELATED THERETO
The disclosure relates to methods of managing blood coagulation and pharmaceutical compositions related thereto. In certain embodiments, the disclosure relates to methods of managing the...
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US20120048407 |
DEVICES AND SYSTEMS FOR MEDICAL FLUID TREATMENT
The devices and systems are medical fluid treatment therapies. The device and systems are configured and capable of operating based on small volumes of fluids. The devices and systems include a...
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US20120040924 |
PURINE NUCLEOSIDE MONOPHOSPHATE PRODRUGS FOR TREATMENT OF CANCER AND VIRAL INFECTIONS
The present invention is directed to compounds, compositions and methods for treating or preventing cancer and viral infections, in particular, HIV, HCV, Norovirus, Saporovirus, HSV-1, HSV-2,...
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8114994 |
2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
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8114884 |
CXCR4 antagonists for the treatment of medical disorders
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
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US20120029932 |
DISPLAY OF PATIENT-SPECIFIC DATA
Systems, methods, and computer-program products identify clinical data corresponding to a plurality of patients located within a common health care delivery unit, and apply one or more rules to at...
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US20120028977 |
Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions
Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive...
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US20120027666 |
POLYOXOMETALATE WATER OXIDATION CATALYSTS AND METHODS OF USE THEREOF
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred embodiment,...
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US20120022086 |
CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS
Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a...
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US20120022070 |
Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and...
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8101718 |
Methods of administering porcine B-domainless fVIII
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
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US20110319416 |
Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions
Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive...
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8080659 |
CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
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US20110306579 |
METHODS OF NEUROPROTECTION USING NEUROPROTECTIVE STEROIDS AND A VITAMIN D
Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective...
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US20110305636 |
COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT
Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein,...
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8071795 |
HIF inhibitors
HIF-1 inhibitors and methods of use thereof are provided.
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US20110294844 |
9-AMINONOSCAPINE AND ITS USE IN TREATING CANCERS, INCLUDING DRUG-RESISTANT CANCERS
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
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8067537 |
Composition and method for treatment of stomatitis
A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a...
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8067424 |
Selective inhibitors for cyclin-dependent kinases
This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from...
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US20110288044 |
Modulation of sodium channels by nicotinamide adenine dinucleotide
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the...
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US20110286919 |
CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs),...
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US20110282587 |
COMPUTER READABLE STORAGE MEDIUMS, METHODS AND SYSTEMS FOR NORMALIZING CHEMICAL PROFILES IN BIOLOGICAL OR MEDICAL SAMPLES DETECTED BY MASS SPECTROMETRY
Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass...
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US20110282081 |
Methods of Preparing 1-Deoxy-Sphingoid Bases and Derivatives Thereof
Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes...
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US20110281908 |
Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer...
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US20110275839 |
COMPOUNDS, INTERMEDIATES, AND METHODS OF PREPARING THE SAME
The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds,...
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US20110274651 |
Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition
Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are...
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US20110263553 |
STEROID ANALOGUES FOR NEUROPROTECTION
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
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US20110262354 |
CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
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8034579 |
Proteins with enhanced functionality and methods of making novel proteins using circular permutation
The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel...
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8032335 |
Evaluating magnetic resonance spectra
Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various...
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US20110235884 |
Atlas-Assisted Synthetic Computed Tomography Using Deformable Image Registration
Disclosed are systems for and methods of creating a synthetic image by registering a reference or atlas image to a clinical image using both rigid and deformable image registration algorithms. In...
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US20110230361 |
PROSTATE CANCER BIOMARKERS TO PREDICT RECURRENCE AND METASTATIC POTENTIAL
Described herein are methods for predicting the recurrence, progression, and metastatic potential of a prostate cancer in a subject. For example, the method comprises detecting in a sample from a...
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US20110224752 |
MICROELECTRODE STIMULATION FOR TREATMENT OF EPILEPSY OR OTHER NEUROLOGIC DISORDER
Methods for treating a neurologic disorder by neurostimulation. The stimulation may be applied using electromagnetic energy. In certain embodiments, distributed electrical stimulation is applied to...
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US20110224181 |
METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
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8008312 |
CXCR4 antagonists for the treatment of HIV infection
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry...
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US20110206699 |
Methods for the Treatment of Graft-Versus-Host Disease
Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and...
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