Patents and Patent Applications from Emory University


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US20160113925 METHODS OF TREATING CANCER WITH A COMBINATION OF GLUCOSE MODULATORS AND BCL-2 INHIBITORS  
This disclosure relates to treating or preventing cancers, such as hematological malignancies, by administering a compound that binds BCL2 and one or more compounds that inhibit glucose or...
US20160113873 NANOCARRIER THERAPY FOR TREATING INVASIVE TUMORS  
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
9321829 Antibodies directed against influenza  
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly...
9320875 Systems for implanting and using a conduit within a tissue wall  
Various embodiments of the present invention provide a conduit system including an outer lumen (810), an inner lumen (805), and an attaching device (820). In other embodiments, a multiple access...
9320509 Suturing devices, systems and methods of using the same  
Provided herein are surgical suturing systems, devices, and methods of using the same. The systems and devices are optionally used in surgeries of the stomach.
US20160108092 Selectin Inhibitors, Composition, and Uses Related Thereto  
This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one more modified amino...
US20160106684 CASEIN COATED DRUG-LOADED IRON OXIDE NANOPARTICLES  
This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising...
US20160102048 N-(4-(BIS(4-(DIMETHYLAMINO)PHENYL)METHYLENE)-8-(DIMETHYLAMINO)  
This disclosure relates to N-(4-(bis(4-(dimethylamino)phenyl)methylene)-8-(dimethylamin o)naphthalen-1(4H)-ylidene)-N-methylmethanaminium, derivatives, and uses related thereto. In certain...
9308015 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20160095859 COMBINATION THERAPIES FOR OVERCOMING RESISTANCE TO MITOTIC AGENTS DURING CHEMOTHERAPY  
This disclosure relates to the uses of compounds that target an interaction between CHFR and PARP1. In certain embodiments, the disclosure relate to treating cancer by administering a mitotic...
9303205 Lattice-mismatched core-shell quantum dots  
The disclosure relates to lattice-mismatched core-shell quantum dots (QDs). In certain embodiments, the lattice-mismatched core-shell QDs are used in methods for photovoltaic or photoconduction...
9301945 Methods for treating inflammatory conditions and states, and cancers by antagonizing NF-κB activation  
The disclosure is directed to methods for treating inflammatory conditions and cancers that have misregulated NF-κB. In some embodiments, the disclosure is directed to methods for treating...
US20160089478 BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO  
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain...
9295754 Noggin inhibitory compositions for ossification and methods related thereto  
This disclosure relates to compounds and compositions for forming bone and methods related thereto. In certain embodiments, the disclosure relates to methods of forming bone comprising implanting...
9295553 Annuloplasty rings and methods for heart valve repair  
An annuloplasty ring, configured for implantation in the annulus of a heart valve, comprising multiple segments each of which are geometrically shaped from a three dimensional perspective to...
US20160085931 SYSTEMS AND METHODS FOR SUPPORTING HOSPITAL DISCHARGE DECISION MAKING  
In one embodiment, a system and method for assisting a physician with a hospital discharge decision pertain to collecting patient data from a patient under consideration who is staying at a...
US20160074119 DEVICES AND SYSTEMS FOR MRI-GUIDED PROCEDURES  
Devices and systems can be configured to guide an instrument to a target region. The guide system may include an imaging guide including a first segment, the first segment including a guide region...
US20160068518 POTENT AND SELECTIVE INHIBITORS OF HEPATITIS C VIRUS  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
US20160067200 USES OF 6-AMINOHEXANOIC ACID TO MANAGE BLEEDING CONDITIONS  
This disclosure relates to the use of EACA (6-aminohexanoic acid) as an antifibrinolytic for the prevention of thrombocytopenic bleeds. In certain embodiment, the disclosure relates to methods of...
US20160052957 PROGESTERONE ANALOGS AND USES RELATED THERETO  
This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation...
US20160051800 VASCULAR CONDUIT DEVICE AND SYSTEM FOR IMPLANTING  
The present invention provides a vascular conduit device including a deformable flange and complementary securing ring in cooperation for securing the device within an aperture defined in a tissue...
US20160051554 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
9266817 Catecholamine derivatives for obesity and neurological disorders  
Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of...
US20160046930 METHODS OF SEQUENCING NUCLEIC ACIDS IN MIXTURES AND COMPOSITIONS RELATED THERETO  
This disclosure relates to analyzing the end-to-end sequence and the relative distributions in heterogeneous mixtures of polynucleotides and methods and enabling reagents related thereto. In...
US20160046687 GM-CSF AND IL-4 CONJUGATES, COMPOSITIONS, AND METHODS RELATED THERETO  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-4 and uses related thereto, e.g., enhancing the immune system. Typically the GM-CSF and IL-4 are connected by...
9262167 Computer processor with instruction for execution based on available instruction sets  
A system and method for testing whether a computer processor is capable of executing a requested instruction set. The system includes a computer processor configured to receive an encoded...
9254319 Compositions and methods for generating an immune response  
We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes,...
US20160030549 RECOMBINANT RSV WITH SILENT MUTATIONS, VACCINES, AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to the polynucleotide sequences of respiratory syncytial virus (RSV). In certain embodiments, the disclosure relates to isolated or recombinant...
US20160030529 TARGETED ELIMINATION OF FACTOR VIII IMMUNE CELLS  
This disclosure relates to composition and methods for improving blood clotting in a subject that developed anti-factor VIII antibodies. In certain embodiments, this disclosure contemplates a...
US20160025717 HYPOSIALYLATION DISORDERS  
Methods are disclosed for diagnosing a hyposialylation disorder. Methods are also disclosed for determining the effectiveness of a therapeutic agent for treatment of a hyposialylation disorder in...
US20160022843 COATED MAGNETIC NANOPARTICLES FOR IMAGING ENHANCEMENT AND DRUG DELIVERY  
This disclosure is in the area of diagnostics and nanotechnology. This disclosure provides a method for synthesizing casein coated iron oxide nanoparticles to be used as an MRI contrasting agent...
US20160022767 PROTEIN PARTICLES COMPRISING DISULFIDE CROSSLINKERS AND USES  
This disclosure relates to particles comprising recombinant proteins, pharmaceutical composition comprising the particles, and therapeutic uses related thereto. In certain embodiments, the...
US20160009801 SPECIFIC BINDING AGENTS OF GLYCOPROTEIN IB ALPHA AS SELECTIVE ECTODOMAIN SHEDDING INHIBITORS  
This disclosure relates to specific binding agents, such as isolated recombinant monoclonal antibodies, that bind Glycoprotein Ib alpha (GPIba). More specifically, the disclosure relates to...
US20160008492 COMPOSITIONS OF SACCHARIDE COATED NANOPARTICLES AND USES  
This disclosure relates to nanoparticles of metals, alloys, metal oxides, and multi-metallic oxides comprising oligosaccharide coatings and uses such as in molecular imaging. Typically, the...
US20160008466 PARTICLE COMPOSITIONS AND METHODS RELATED THERETO  
The disclosure relates to metal particles compositions and uses related thereto. In certain embodiments, the disclosure relates to metal particles such as iron particles and their application in...
US20160002174 CXCR4 Antagonists for the Treatment of Medical Disorders  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
US20150374694 TGF-BETA ENHANCING COMPOSITIONS FOR CARTILAGE REPAIR AND METHODS RELATED THERETO  
This disclosure relates to compounds and compositions for cartilage repair and methods related thereto. In certain embodiments, the disclosure relates to methods of inducing cartilage growth and...
9220682 Nanocarrier therapy for treating invasive tumors  
Liposomes of a size of less than 200 nanometers target tumors and preferentially deliver imipramine blue to tumors, including brain tumors such as gliomas. The imipramine blue decreases the...
US20150368668 HCV E2 CONSTRUCT COMPOSITIONS AND METHODS  
Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
US20150366933 TREATMENT OF KLEBSIELLA PNEUMONIAE WITH LIPOSOMALLY FORMULATED GLUTATHIONE  
The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as...
US20150359766 METHODS OF TREATING AUTISM WITH mGluR5 ANTAGONISTS  
mGluR5 antagonists are used for the treatment of autism. The human treated by the methods of the invention can also have fragile X syndrome, epilepsy and anxiety.
US20150353905 CAS9-NUCLEIC ACID COMPLEXES AND USES RELATED THERETO  
This disclosure relates to Cas9-nucleic acid complexes and uses related thereto. In certain embodiments, the disclosure contemplates transgenic plants and animals genetically engineered to express...
US20150352190 Modified Factor VIII  
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
9205085 Tricyclic amino containing compounds for treatment or prevention of symptoms associated with endocrine dysfunction  
The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
US20150347680 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA FOR ANALYZING A SAMPLE  
Methods, systems, and computer readable storage media relate to processing and analyzing a sample to determine presence or concentration of at least one sensor target in a sample. A method of...
US20150335765 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
US20150335685 ENGINEERED STEM CELL THERAPY FOR CARDIAC REPAIR  
This disclosure relates to compositions and methods of cardiac repair. In certain embodiments, the disclosure relates to a composition comprised of peptide amphiphiles and cardiac and/or cardiac...
US20150329912 BIOMARKERS IN CANCER, METHODS, AND SYSTEMS RELATED THERETO  
This disclosure relates biomarkers of cancer, e.g. prostate cancer. The biomarkers may be altered expression of nucleic acids, mutations, or proteins encoded therefrom. In certain embodiments, the...
9181227 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
9180138 2′-fluoronucleosides  
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and...