Patents and Patent Applications from Emory University


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9868728 Quinazoline derivatives, compositions, and uses related thereto  
The invention relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the invention relates to inhibitors of NADPH-oxidase.
US20180009873 FACTOR VIII PROTEINS HAVING ANCESTRAL SEQUENCES, EXPRESSION VECTORS, AND USES RELATED THERETO  
This disclosure relates to recombinant or chimeric FVIII proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more...
9867041 Methods and systems for determining protected location information based on temporal correlations  
The systems and methods can provide location privacy protection by incorporating temporal correlations of a user's locations. The method may include obtaining a first location of a user of a...
9861693 HIV immune stimulating compositions comprising recombinantly expressed pili on bacteria and methods related thereto  
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant...
9861652 2′ Fluoronucleosides  
2′-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and...
9858687 Systems, methods, and computer readable storage media storing instructions for generating an image integrating functional, physiological and anatomical images  
Systems, methods and computer-readable storage mediums relate to generating an image that includes functional, anatomical, and physiological images. The generated image may be an integrated image...
9856534 Selecting use of proteasome inhibitors based on NF-κB2 sequence  
Provided herein are methods for selecting use of proteasome inhibitors.
US20170369417 TAK1 Kinase Inhibitors, Compositions, and Uses Related Thereto  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a...
US20170354747 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
9840693 Polypeptide hydrogels and uses related thereto  
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to...
9833777 Water oxidation catalysts and methods of use thereof  
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred...
US20170343561 DIAGNOSTIC AND THERAPEUTIC METHODS AND PRODUCTS RELATED TO ANXIETY DISORDERS  
The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of...
9827222 Treating or preventing nephrogenic diabetes insipidus  
In certain embodiments, the disclosure relates to methods of treating or preventing nephrogenic diabetes insipidus comprising administering an effective amount of a AMPK activator to a subject in...
US20170334941 2',2'-DIHALO NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER  
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya Ebola and West...
US20170333366 Casein Coated Drug-Loaded Iron Oxide Nanoparticles  
This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising...
9821071 Oligosaccharide conjugates for targeting bacteria and uses related thereto  
This disclosure relates to conjugates for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a molecule of interest into bacteria...
US20170326256 RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF  
Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor....
US20170322275 Magnetic Resonance Method And Apparatus For Quantitative Simultaneous Multi-Slice Assessment Of Tissue Displacement, Deformation, And Related Biomarker Parameters  
Embodiments relate to a magnetic resonance imaging (MRI) technique in which the two-dimensional (2D) Displacement Encoding with Stimulated Echoes (DENSE) imaging technique and the multiband...
9809616 Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer  
The compounds are of the class of N4-hydroxycytidine nucleosides, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives...
9808464 Compounds and compositions for ossification and methods related thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
US20170313719 Thieno[2,3-D]pyrimidin-4-one Derivatives as NMDAR Modulators and Uses Related Thereto  
The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical...
US20170312283 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
9803197 Particle-nucleic acid conjugates and therapeutic uses related thereto  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...
9802978 Progesterone phosphate analogs and uses related thereto  
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing...
9801953 Nanoparticles carrying nucleic acid cassettes for expressing RNA  
This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression...
9801898 Glutamate dehydrogenase 1 inhibitors and methods of treating cancer  
This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof. In certain...
US20170305876 7,8-DIHYDOXYFLAVONE AND 7,8-SUBSTITUTED FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20170304365 COMPOSITIONS, USES, AND PREPARATION OF PLATELET LYSATES  
In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium...
US20170304039 Soft Tissue Implant Systems, Kits, Implants, Devices and Associated Methods  
The disclosure may relate to implant systems, kits, implants, devices, and associated methods that can quickly, easily and accurately deliver a soft tissue implant with minimal incisions/trauma to...
9795763 Delivery devices, systems and methods for delivering therapeutic agents  
Delivery devices, systems, and methods are configured to enhance retention of a therapeutic agent delivered at a treatment site, for example, via impeding agent backflow. A device may include...
US20170296528 Methods of Managing Conditioned Fear with Neurokinin Receptor Antagonists  
This disclosure relates to managing conditioned fear and conditions induced by experiencing or witnessing an extreme traumatic event using neurokinin receptor antagonists. In certain embodiments,...
9789155 Methods of improving behavioral therapies  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
9788995 Methods and devices for drug delivery to ocular tissue using microneedle  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
US20170290906 VLPS Containing Ligands and Methods Related Thereto  
This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a...
US20170285020 Anti-Fouling Siloxane Polymers and Uses Related Thereto  
This disclosure relates to polymer coatings with desirable anti-fouling properties. In certain embodiments, polymers are coated on particles which allow for conjugation with targeting moieties. In...
US20170281069 Methods and Systems for Determining Sensory Motor Performance Based on Non-Postural Information  
Methods and systems relate to determining sensory motor performance based on user non-postural movements within a generated dynamic virtual environment. The generated environment requires users...
US20170276690 Visually-Based Diagnostic Device for Automatic Determination of a Physiologic Level Associated with a Sample  
Diagnostic devices; systems, methods and computer-readable media store instructions related to determining hemoglobin information using those devices. The methods may include processing a captured...
US20170274087 SACCHARIDE ANALOGS AND AGENTS FOR THE DIAGNOSIS AND THERAPY OF BACTERIAL INFECTIONS  
This disclosure relates saccharide analogs such as thiomaltose-based analogs for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a...
US20170273827 APPARATUS AND METHODS FOR DRUG DELIVERY USING MICRONEEDLES  
A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication...
US20170273555 INTERNET-BASED COGNITIVE DIAGNOSTICS USING VISUAL PAIRED COMPARISON TASK  
Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for...
9772337 Compositions and methods for functional gylcomics  
The disclosure relates to labeling glycans and glycosphingolipids from undefined mixtures with chemical moieties that emit light when exposed to electromagnetic radiation and uses of these labeled...
US20170266188 Methods For the Treatment of Cancer  
The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating...
US20170260575 Devices and Methods Useful for Detecting Mechanical Forces of Ligand Receptor Interactions  
This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting...
US20170258904 Antagonism of the VIP Signaling Pathway  
Inhibition of the VIP signaling pathway with VIP antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising...
9758809 RNA splicing alterations and U1 small nuclear ribonucleoproteins in neurodegenerative diseases  
This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or RNA or RNA expression profiles in a subject. In...
9758794 HCV E2 construct compositions and methods  
Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
US20170252411 Compositions Derived from Platelet Lysates and Uses in Vascularization  
This disclosure relates to compositions comprising a fibrin polymer produced by mixing platelet lysates with a minimal essential medium and thrombin. Typically, an optimized concentration of a...
9751825 TAK1 kinase inhibitors, compositions, and used related thereto  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a...
9743905 Systems, methods and computer readable storage media storing instructions for generating planning images based on HDR applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
9737880 Photocatalytic polyoxometalate compositions of tungstovanadates and uses as water oxidation catalysts  
This disclosure relates to photocatalytic polyoxometalate compositions of tungstovanadates and uses as water oxidation catalysts. In certain embodiments, the disclosure relates to compositions...