Patents and Patent Applications from Emory University


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US20170326256 RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF  
Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor....
US20170322275 Magnetic Resonance Method And Apparatus For Quantitative Simultaneous Multi-Slice Assessment Of Tissue Displacement, Deformation, And Related Biomarker Parameters  
Embodiments relate to a magnetic resonance imaging (MRI) technique in which the two-dimensional (2D) Displacement Encoding with Stimulated Echoes (DENSE) imaging technique and the multiband...
9809616 Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer  
The compounds are of the class of N4-hydroxycytidine nucleosides, modified monophosphate and phosphonates prodrugs analogs, and pharmaceutically acceptable, salts, prodrugs, and other derivatives...
9808464 Compounds and compositions for ossification and methods related thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
US20170313719 Thieno[2,3-D]pyrimidin-4-one Derivatives as NMDAR Modulators and Uses Related Thereto  
The disclosure relates thieno[2,3-d]pyrimidin-4-one derivatives as modulators of NMDA receptors and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical...
US20170312283 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
9803197 Particle-nucleic acid conjugates and therapeutic uses related thereto  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...
9802978 Progesterone phosphate analogs and uses related thereto  
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing...
9801953 Nanoparticles carrying nucleic acid cassettes for expressing RNA  
This disclosure relates to nanoparticles carrying nucleic acid cassettes for expressing RNA. In certain embodiments, the disclosure relates to improved methods for targeted delivery and expression...
9801898 Glutamate dehydrogenase 1 inhibitors and methods of treating cancer  
This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof. In certain...
US20170305876 7,8-DIHYDOXYFLAVONE AND 7,8-SUBSTITUTED FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to 7,8-dihydoxyflavone and 7,8-substituted flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and...
US20170304365 COMPOSITIONS, USES, AND PREPARATION OF PLATELET LYSATES  
In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium...
US20170304039 Soft Tissue Implant Systems, Kits, Implants, Devices and Associated Methods  
The disclosure may relate to implant systems, kits, implants, devices, and associated methods that can quickly, easily and accurately deliver a soft tissue implant with minimal incisions/trauma to...
9795763 Delivery devices, systems and methods for delivering therapeutic agents  
Delivery devices, systems, and methods are configured to enhance retention of a therapeutic agent delivered at a treatment site, for example, via impeding agent backflow. A device may include...
US20170296528 Methods of Managing Conditioned Fear with Neurokinin Receptor Antagonists  
This disclosure relates to managing conditioned fear and conditions induced by experiencing or witnessing an extreme traumatic event using neurokinin receptor antagonists. In certain embodiments,...
9789155 Methods of improving behavioral therapies  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
9788995 Methods and devices for drug delivery to ocular tissue using microneedle  
Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an...
US20170290906 VLPS Containing Ligands and Methods Related Thereto  
This disclosure relates to immunogenic compositions and methods of enhancing an immune response to an antigen. In certain embodiments, the disclosure relates to virus-like carries comprising a...
US20170285020 Anti-Fouling Siloxane Polymers and Uses Related Thereto  
This disclosure relates to polymer coatings with desirable anti-fouling properties. In certain embodiments, polymers are coated on particles which allow for conjugation with targeting moieties. In...
US20170281069 Methods and Systems for Determining Sensory Motor Performance Based on Non-Postural Information  
Methods and systems relate to determining sensory motor performance based on user non-postural movements within a generated dynamic virtual environment. The generated environment requires users...
US20170276690 Visually-Based Diagnostic Device for Automatic Determination of a Physiologic Level Associated with a Sample  
Diagnostic devices; systems, methods and computer-readable media store instructions related to determining hemoglobin information using those devices. The methods may include processing a captured...
US20170274087 SACCHARIDE ANALOGS AND AGENTS FOR THE DIAGNOSIS AND THERAPY OF BACTERIAL INFECTIONS  
This disclosure relates saccharide analogs such as thiomaltose-based analogs for targeting bacteria and related uses. In certain embodiments, the disclosure relates to methods of transferring a...
US20170273827 APPARATUS AND METHODS FOR DRUG DELIVERY USING MICRONEEDLES  
A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication...
US20170273555 INTERNET-BASED COGNITIVE DIAGNOSTICS USING VISUAL PAIRED COMPARISON TASK  
Disclosed are methods for diagnosing declarative memory loss using mouse tracking to follow the visual gaze of a subject taking a visual paired comparison test. Also disclosed are methods for...
9772337 Compositions and methods for functional gylcomics  
The disclosure relates to labeling glycans and glycosphingolipids from undefined mixtures with chemical moieties that emit light when exposed to electromagnetic radiation and uses of these labeled...
US20170266188 Methods For the Treatment of Cancer  
The invention provides combinations comprising a MERTK inhibitor, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor and methods of use thereof, including methods of treating...
US20170260575 Devices and Methods Useful for Detecting Mechanical Forces of Ligand Receptor Interactions  
This disclosure related to methods of detecting mechanical forces required to separate ligand and receptor interactions. In certain embodiments, this disclosure relates to methods of detecting...
US20170258904 Antagonism of the VIP Signaling Pathway  
Inhibition of the VIP signaling pathway with VIP antagonist is contemplated. In certain embodiments, the disclosure relates to methods of enhancing the immune response to a cell therapy comprising...
9758809 RNA splicing alterations and U1 small nuclear ribonucleoproteins in neurodegenerative diseases  
This disclosure relates to methods of diagnosing neurodegenerative disease by analyzing proteins or protein expression profiles in a subject, or RNA or RNA expression profiles in a subject. In...
9758794 HCV E2 construct compositions and methods  
Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
US20170252411 Compositions Derived from Platelet Lysates and Uses in Vascularization  
This disclosure relates to compositions comprising a fibrin polymer produced by mixing platelet lysates with a minimal essential medium and thrombin. Typically, an optimized concentration of a...
9751825 TAK1 kinase inhibitors, compositions, and used related thereto  
The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula (I), pharmaceutical compositions having a...
9743905 Systems, methods and computer readable storage media storing instructions for generating planning images based on HDR applicators  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on one or more applicators inserted into a target of a patient. The method may include receiving...
9737880 Photocatalytic polyoxometalate compositions of tungstovanadates and uses as water oxidation catalysts  
This disclosure relates to photocatalytic polyoxometalate compositions of tungstovanadates and uses as water oxidation catalysts. In certain embodiments, the disclosure relates to compositions...
9737522 NMDA receptor modulators and uses related thereto  
This disclosure relates to NMDA modulators and used related thereto such as for treatment of central nervous system disorders. In certain embodiments, compounds disclosed herein are NR2C...
9737492 Casein coated drug-loaded iron oxide nanoparticles  
This disclosure relates to nanoparticle drug delivery systems composed of casein (CN) coated nanoparticles, e.g., iron oxide nanoparticles coated with an inner layer and an out layer comprising...
US20170233428 NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER  
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever, Dengue, Chikungunya and West Nile...
US20170231522 Magnetic Resonance Method And Apparatus For Quantitative Time-Resolved Assessment Of Tissue Displacement And Related Biomarker Parameters With Blood Suppression In The Whole Cardiac Cycle  
Embodiments relate to acquiring magnetic resonance (MR) images with suppressed residual blood signal in the early cardiac phases, leading to images with a preferred dark-blood appearance...
US20170226173 GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto  
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g.,...
US20170224322 Sternal Retractor  
Devices and methods for sternal retraction that reduces bleeding from the cut edges of a sternum and reduces fracturing of the sternum during retraction. The devices and methods involve the use of...
9725499 Self-assembling collagen-like polypeptide sequences for applications and uses related thereto  
This disclosure relates to collagen like polypeptides, applications, and uses related thereto. In certain embodiments, the disclosure relates to collagen like polypeptides wherein hydroxy proline...
9724412 Chymase compositions, antibodies, diagnostics, and therapeutic methods related thereto  
The disclosure relates to chymase, antibodies to chymase, and diagnostic and therapeutic methods relates thereto. It has been discovered that above certain circulating levels of chymase, a patient...
US20170216561 Delivery Devices, Systems and Methods for Delivering Therapeutic Materials  
Delivery devices, systems, and methods may be configured to define a barrier region at a treatment site to deliver one or more therapeutic materials. A device for delivering one or more...
US20170216319 Treating Various Disorders Using TrkB Agonists  
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
US20170209572 Classifiers of NF-kB Pathway Activation, Devices, and Methods of Use Thereof  
This disclosure relates to classifiers of NF-κB pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in...
US20170198303 Methods, Devices and Systems for Enhanced Transduction Efficiency  
The systems and methods are directed to leveraging the channel geometry and configuration to overcome diffusion limitations of current transduction systems. The methods may include a method of...
US20170196885 USE OF GABAA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EXCESSIVE SLEEPINESS AND DISORDERS ASSOCIATED WITH EXCESSIVE SLEEPINESS  
GABAA receptor mediated hypersomnia can be treated by administering a GABAA receptor antagonist (e.g., flumazenil; clarithromycin; picrotoxin; bicuculline; cicutoxin; and oenanthotoxin). In some...
9700881 Heterocyclic coupling catalysts and methods related thereto  
This disclosure relates to synthetic coupling methods using a catalytic molecule comprising two bonded atoms wherein one atom is an amide nitrogen and the second atom is not nitrogen or carbon,...
9688959 Compositions, uses, and preparation of platelet lysates  
In certain embodiments, this disclosure describes compositions comprising platelet lysates depleted of fibrinogen. In a further embodiment, the composition further comprises a cell culture medium...
US20170173306 SPITTABLE NEEDLE  
Splittable needles for use in catheterizations are described. The splittable needles are formed of equal or unequal longitudinal parts that precisely align and lock for secure access to subject's...