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Patents and Patent Applications from Emory University


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US20150239972 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20150238593 MVA EXPRESSING MODIFIED HIV ENVELOPE, GAG AND POL GENES  
The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
US20150232558 STIMULATING BONE FORMATION BY INHIBITION OF CD28 CO-STIMULATION  
The disclosure relates to methods of growing bone or increasing bone mineral density and/or volume comprising administering an effective amount of a therapeutic containing abatacept or belatacept...
US20150231228 HIV IMMUNE STIMULATING COMPOSITIONS COMPRISING RECOMBINANTLY EXPRESSED PILI ON BACTERIA AND METHODS RELATED THERETO  
This disclosure relates to recombinant bacteria, e.g. L. lactis, expressing heterologous pili containing human immunodeficiency virus (HIV) antigens. In certain embodiments, the recombinant...
US20150231227 COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE  
Novel plasmid constructs useful for the delivery of DNA vaccines are provided having a transcription cassette capable of directing the expression of a vaccine nucleic acid insert encoding...
9107696 Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus  
A method of embryo transfer (“ET”) that improves fertility rates by eliminating transferred air during the procedure is provided. Also provided is a method for hormonally enhancing the uterine...
9102727 Human anti-PD-1 antibodies and uses therefor  
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing,...
US20150216906 POLYPEPTIDE HYDROGELS AND USES RELATED THERETO  
This disclosure relates to self-assembling peptides that form hydrogels comprising peptide sequences for the activation of signaling pathways. In certain embodiments, the disclosure relates to...
US20150209180 Apparatus and Methods for Drug Delivery Using Microneedles  
A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication...
9089574 Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
US20150206302 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR INTEGRATING FLUOROSCOPY VENOGRAM AND MYOCARDIAL IMAGES  
Systems, methods, and computer-readable storage media relate to generate an integrated image including fluoroscopy venogram and myocardial image with left-ventricular (LV) contraction sequence and...
US20150203442 Anthraquinone Analogs and Methods of Making and Using Thereof  
Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings...
US20150196540 NMDA RECEPTOR MODULATORS AND USES RELATED THERETO  
This disclosure relates to NMDA modulators and used related thereto such as for treatment of central nervous system disorders. In certain embodiments, compounds disclosed herein are NR2C...
9079852 NMDA receptor antagonists for neuroprotection  
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain...
US20150191481 HETEROCYCLIC FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical compositions, and methods related thereto. In...
9073751 Quantum dots, methods of making quantum dots, and methods of using quantum dots  
Embodiments of the present disclosure provide: methods of making a quantum dot, quantum dots, and the like.
US20150183837 IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF  
Embodiments of the disclosure encompass compositions and methods for generating immune responses in an animal or human host. Embodiments of the compositions encompass proteins derived from the...
US20150183736 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
US20150182729 CATHETER SYSTEM FOR DELIVERY OF SOLUTIONS  
A catheter system may include an adapter and a catheter configured to improve the field of vision and support of a catheter during surgical and interventional procedures, such as open-heart...
US20150174273 IMAGING AND THERAPEUTIC METHODS FOR TREATING PARATHYROID TUMORS  
It has been discovered that human parathyroid tumor cells express high densities of folate receptors which could provide a target that may be used for localization. In certain embodiments, the...
US20150174112 COMPOSITIONS FOR TREATING FRAGILE X AND OTHER DISORDERS METHODS OF USE THEREOF, AND SCREENING FOR COMPOUNDS FOR FRAGILE X AND OTHER DISORDERS  
Methods of screening compounds, active compositions, pharmaceutical compositions, methods of treating disorders, methods of preventing disorders, and kits to screen a library of compounds, are...
US20150174107 TRKB AGONISTS AND METHODS OF USE  
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-dihydroxyflavone derivative with modified flavone or heterocyclic ring to...
9062072 Inhibitors of HIF and angiogenesis  
Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for...
9061121 Targeting therapeutic agents  
Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration...
9061077 Methods of determining renal function using technetium-99m tricarbonyl-nitrilotriacetic acid  
This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracer 99mTc(CO)3(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure...
US20150167097 CLASSIFIERS OF NF-kB PATHWAY ACTIVATION, DEVICES, AND METHODS OF USE THEREOF  
This disclosure relates to classifiers of NF-κB pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in...
US20150166989 PARTICLE-NUCLEIC ACID CONJUGATES AND THERAPEUTIC USES RELATED THERETO  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...
US20150165009 TLR5 LIGANDS, THERAPEUTIC METHODS, AND COMPOSITIONS RELATED THERETO  
The disclosure relates to antiviral therapeutic methods and related compositions. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection by...
US20150158925 METHODS OF MANAGING GRAFT VERSUS HOST DISEASE  
This disclosure relates to the use of drugs to prevent graft versus host disease (GVHD) in a subject after, before, or during a hematopoietic stem cell transplant. In certain embodiments, the...
US20150157630 CHEMOKINE CXCR4 RECEPTOR MODULATORS AND USED RELATED THERETO  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
9045727 Virus-like particles, methods of preparation, and immunogenic compositions  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using...
US20150148407 OPTOGENETIC INHIBITION OF OVERACTIVE NEURONAL ACTIVITY  
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain...
US20150148321 SUBSTITUTED ANDROST-4-ENE DIONES  
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds...
US20150148292 BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO  
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain...
9040713 Methods of managing blood sugar levels and compositions related thereto  
The disclosure relates to methods of managing blood sugar levels and compositions related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diabetes,...
9040567 BAX agonist, compositions, and methods related thereto  
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
US20150140670 KITS AND METHODS FOR DETERMINING PHYSIOLOGIC LEVEL(S) AND/OR RANGE(S) OF HEMOGLOBIN AND/OR DISEASE STATE  
Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator...
9035028 Temperature sensitive conjugate compositions  
This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a...
US20150133522 MANIPULATING MICRORNA FOR THE MANAGEMENT OF NEUROLOGICAL DISEASES OR CONDITIONS AND COMPOSITIONS RELATED THERETO  
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of...
9029561 TRKB agonists and methods of use  
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-dihydroxyflavone derivative with modified flavone or heterocyclic ring to...
US20150125057 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR IMAGING AND DETERMINING INFORMATION ASSOCIATED WITH REGIONS OF THE BRAIN  
Methods, systems and computer-readable storage mediums relate to imaging techniques of a region, for example, the brain, with magnetization transfer contrast (MTC°) effects with less specific...
D728800 Surgical arm support  
US20150110723 QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO  
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or...
8989462 Systems, methods and computer readable storage mediums storing instructions for applying multiscale bilateral filtering to magnetic resonance (RI) images  
Systems, methods and computer-readable storage mediums relate to segmenting MR images using multiscale bilateral filtering. Before the multiscale bilateral filtering, the MR images are transformed...
US20150072420 THERAPEUTIC USE OF CD31 EXPRESSING CELLS  
As described below, the present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.
US20150071987 IMMUNOSTIMULATORY COMPOSITIONS, PARTICLES, AND USES RELATED THERETO  
In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition...
8975428 Dirhodium catalyst compositions and synthetic processes related thereto  
This disclosure relates to compositions comprising dirhodium catalysts and uses related thereto, e.g., in enantioselective transformations of donor/acceptor carbenoids. In certain embodiments, the...
US20150065526 OVERCOMING ACQUIRED RESISTANCE TO CHEMOTHERAPY TREATMENTS THROUGH SUPPRESSION OF STAT3  
This disclosure relates to methods of treating cancer comprising administering an effective amount of a STAT3 inhibitor, prodrugs, or derivatives thereof, in combinations with an EGFR tyrosine...
US20150064286 PREPARATION AND COMPOSITIONS OF HIGHLY BIOAVAILABLE ZEROVALENT SULFUR AND USES THEREOF  
The present invention features sulfur-rich compositions and preparations thereof that are safe and effective as hydrogen sulfide prodrugs of high bioavailability. The invention also includes...
8969381 Chemokine CXCR4 receptor modulators and used related thereto  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...