Patents and Patent Applications from Emory University


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US20190112603 Methods and Compositions for Managing Vascular Conditions Using miR-483 Mimics and HIF1alpha Pathway Inhibitors  
This disclosure relates to the use of miRNA-483 and its target genes, UBE2C, pVHL and HIF1alpha, in managing the treatment of cardiovascular and inflammatory diseases. In certain embodiments, this...
10253071 Selectin inhibitors, composition, and uses related thereto  
This disclosure relates to selectin inhibitors, compositions, and methods related thereto. In certain embodiments, the disclosure relates to glycopeptides that contain one more modified amino...
US20190099449 Methods of Preserving Mesenchymal Stem Cells  
This disclosure relates to methods of preserving mesenchymal stromal/stem cells (MSCs) for use in clinical applications. In certain embodiments, this disclosure relates to methods of preserving...
US20190091259 Selective Chemotherapy Treatments and Diagnostic Methods Related Thereto  
This disclosure relates to methods of identifying subjects that have an increased likelihood of responding to a combination of a poly (ADP) ribose polymerase enzyme inhibitor and a platinum based...
10238614 Uses of 6-aminohexanoic acid to manage bleeding conditions  
This disclosure relates to the use of EACA (6-aminohexanoic acid) as an antifibrinolytic for the prevention of thrombocytopenic bleeds. In certain embodiment, the disclosure relates to methods of...
US20190085013 NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO  
This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside...
US20190084980 Amide-Sulfamide Derivatives, Compositions, and Uses Related to CXCR4 Inhibition  
This disclosure relates amide-sulfamide compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula I, salts, derivatives, and prodrugs...
US20190083520 N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto  
This disclosure relates to certain N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment or prophylaxis of a...
10234466 Kits and methods for determining physiologic level(s) and/or range(s) of hemoglobin and/or disease state  
Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator...
10232032 Recombinant RSV with silent mutations, vaccines, and methods related thereto  
In certain embodiments, the disclosure relates to the polynucleotide sequences of respiratory syncytial virus (RSV). In certain embodiments, the disclosure relates to isolated or recombinant...
10228378 Diagnostic and therapeutic methods and products related to anxiety disorders  
The present disclosure provides methods for diagnosing and treating anxiety disorders in female subjects. Diagnosis and treatment of such anxiety disorders are based, in part, on an analysis of...
10227584 Methods of sequencing nucleic acids in mixtures and compositions related thereto  
This disclosure relates to analyzing the end-to-end sequence and the relative distributions in heterogeneous mixtures of polynucleotides and methods and enabling reagents related thereto. In...
10227569 Respiratory syncytial virus expression vectors  
In certain embodiments, the disclosure relates to vectors containing bacterial nucleic acid sequences and a paramyxovirus gene. Typically, the expression vector comprises a bacterial artificial...
US20190062364 PHOSPHORAMIDATES FOR THE TREATMENT OF HEPATITIS B VIRUS  
Disclosed are compounds to the treatment of infectious diseases and methods of treating such diseases. The compounds are derivatives of clevudine.
10213200 Tissue-cutting and -sealing forceps  
Implementations of the disclosed technology include a forcipate surgical instrument including a channel at the working end for guiding a scalpel blade during tissue resection. In some...
10208107 Antibodies directed against influenza  
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly...
10207984 Cyclopropyl derivatives and methods of use  
The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions...
10206976 Protein particles comprising disulfide crosslinkers and uses related thereto  
This disclosure relates to particles comprising recombinant proteins, pharmaceutical composition comprising the particles, and therapeutic uses related thereto. In certain embodiments, the...
10206955 Compositions of ascorbic acid and bone morphogenetic protein 4 (BMP-4) for cell growth and uses related thereo  
This disclosure relates to compositions comprising ascorbic acid and bone morphogenetic protein 4 (BMP-4) for growing cells and making tissues. In certain embodiments, this disclosure relates to...
US20190040208 Polymers of Polyoxometalates and Hydroxy-Terminated Monomer Units and Uses in Degrading Noxious Agents  
This disclosure relates to polymers and polymer compositions having monomer units of polyoxometalates and monomer units comprising hydroxy-terminated molecules such as branched molecules or...
US20190038777 INJECTION OF SINGLE-STRANDED OR SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS 9 INTO THE CEREBROSPINAL FLUID  
It is disclosed herein that ssAAV and scAAV vectors of the same serotype administered by injection into the cerebrospinal fluid (CSF) via the intracerebroventricular (ICV) or intrathecal...
10195241 Botanical extracts and compounds from Castanea plants and methods of use  
This disclosure relates to extracts from chestnut plants and compositions comprising compounds contained therein. In certain embodiments, the extracts are derived from the leaves of a Castanea...
US20190031758 COMPOSITIONS AND METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20190030007 FORMULATION OF A RILUZOLE SOLUTION WITH BETA-CYCLODEXTRINS  
The present invention provides methods for parenterally administering riluzole to subjects in need of treatment.
10188805 Targeting therapeutic agents  
Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration...
US20190025328 TROPONIN I AND SOLUBLE UROKINASE RECEPTOR DETECTION FOR DETERMINING THE RISK OF CARDIOVASCULAR DISEASE  
Disclosed are systems and methods for detecting the sample concentration of cardiac troponin I (cTnI) and the sample concentration of soluble urokinase receptor (suPAR) to determine if a subject...
US20190022116 N4-Hydroxycytidine and Derivatives and Anti-Viral Uses Related Thereto  
This disclosure relates to N4-hydroxycytidine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to the treatment and prophylaxis of viral...
US20190016772 GM-CSF and IL-4 Conjugates, Compositions, and Methods Related Thereto  
In certain embodiments, this disclosure relates to conjugates comprising a polypeptide of GM-CSF and a polypeptide IL-4. Typically, the GM-CSF and IL-4 are connected by a linker, e.g.,...
US20190015432 Lipid Disulfide Prodrugs and Uses Related Thereto  
This disclosure relates to lipid disulfide prodrugs and in particular to lipid disulfide phosphodiester nucleosides and derivatives thereof, pharmaceutical compositions, and uses related thereto....
US20190008840 Bis-amines, Compositions, and Uses Related to CXCR4 Inhibition  
This disclosure relates bis-amine compounds disclosed herein and uses related to CXCR4 inhibition. In certain embodiments, the compounds have formula (I), salts, derivatives, and prodrugs thereof...
US20190002404 PGAM1 Inhibitors and Methods Related Thereto  
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1...
10168341 Devices for determining cell force properties and methods of manufacturing the devices  
A device may be configured to allow individual measuring of at least one property of at least one cell, such as measuring a contraction force of a platelet. The device may include a plurality of...
10167330 Modified recombinant variable lymphocyte receptors (VLR)  
This disclosure relates to variable lymphocyte receptors (VLRs) modifications such as humanized sequences and polypeptides comprising such sequences that specifically bind a target molecule and...
US20180371455 Arrays of Intersecting Double Stranded Nucleic Acid Helices  
This disclosure relates to intersecting double stranded nucleic acid helices with flexible intersections that form antijuction units. In a typical embodiment, the configuration of the intersecting...
US20180371084 HUMAN ANTI-PD-1, PD-L1, AND PD-L2 ANTIBODIES AND USES THEREFOR  
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing,...
US20180369214 Methods of Diagnosing and Treating Small Cell Lung Cancer Using Polo-Like Kinase 1 (PLK1) Inhibitors  
This disclosure relates to methods of diagnosing and treating small cell lung cancer. In certain embodiments, this disclosure relates to methods of treating small cell lung cancer comprising...
US20180362984 Methods and Compositions for Managing Vascular Conditions  
This disclosure relates to methods and compositions for managing vascular conditions by targeting microRNA. In certain embodiments, the disclosure relates to antisense, RNA interference, and...
US20180362584 Peptides That Target Inflamed or Distressed Cardiac Tissue and Uses Related Thereto  
This disclosure relates to peptides useful for targeting inflamed or distressed tissue and uses related thereto. In certain embodiment, the peptides comprise SEQ ID NO: 1-14, or variants or...
10155946 Particle-nucleic acid conjugates and therapeutic uses related thereto  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...
10154989 Methods of managing graft versus host disease (GvHD) using indole carboxyaldehydes or derivatives thereof  
In certain embodiments, this disclosure relates to methods of treating or preventing HvGD comprising administering an effective amount of indole-2-carboxyaldehyde, indole-3-carboxyaldehyde, or...
US20180355039 METHODS OF REDUCING LIVER PD-1-EXPRESSING CD8+ T CELLS USING PD-1 FC FUSION PROTEINS THAT BIND FC RECEPTORS  
The present invention relates to methods of reducing liver PD-1-expressing CD8+ T cells using PD-1 Fc fusion proteins that bind Fc receptors, as well as diagnostic, prognostic, therapeutic methods...
10149859 Nucleotide and nucleoside therapeutic compositions and uses related thereto  
This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside...
10149672 Devices and methods for stabilizing tissue  
The devices and methods relate to devices for stabilizing and/or positioning tissue (e.g., heart) within a surgical area. The device may include an articulating arm and a tissue stabilizing...
US20180346445 Pyrazoline Dihydroquinolones, Pharmaceutical Compositions, and Uses  
This disclosure relates to pyrazoline dihydroquinolone derivatives, pharmaceutical compositions, and uses. In certain embodiments, the compounds are selective NMDA receptor inhibitors and are...
US20180344877 RECOMBINANT PROMOTERS AND VECTORS FOR PROTEIN EXPRESSION IN LIVER AND USE THEREOF  
Disclosed herein are recombinant viral vectors comprising a liver specific promotor in operable combination with a heterologous nucleic acid sequence encoding a protein, such as a clotting factor....
US20180344845 ANTI-CD40 ANTIBODIES AND USES THEREOF  
The present invention relates to antibodies specific for a particular epitope on CD40 and antibodies that bind CD40 and have particular functional characteristics. The present invention also...
US20180343938 Anti-Fog Ventilating Face Masks  
Ventilating face masks and methods and systems for face mask ventilation are disclosed. In some embodiments, a mask ventilation system can comprise an expandable base layer comprising side edges...
US20180340942 Methods of Culturing and Characterizing Antibody Secreting Cells  
This disclosure relates to methods of culturing and characterizing antibody secreting cells. In certain embodiments, this disclosure relates to methods of isolating antibody secreting cells, e.g.,...
10137208 Vivo tumor targeting and spectroscopic detection with surface-enhanced raman nanoparticle tags  
Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the...
US20180333477 CHIMERIC RSV, IMMUNOGENIC COMPOSITIONS, AND METHODS OF USE  
This disclosure relates to chimeric respiratory syncytial virus (RSV), live attenuated vaccine and immunogenic compositions, and methods of use. In certain embodiments, the chimeric respiratory...