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Patents and Patent Applications from Emory University


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US20150174273 IMAGING AND THERAPEUTIC METHODS FOR TREATING PARATHYROID TUMORS  
It has been discovered that human parathyroid tumor cells express high densities of folate receptors which could provide a target that may be used for localization. In certain embodiments, the...
9062072 Inhibitors of HIF and angiogenesis  
Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for...
9061121 Targeting therapeutic agents  
Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration...
9061077 Methods of determining renal function using technetium-99m tricarbonyl-nitrilotriacetic acid  
This disclosure relates to the methods of imaging the kidneys and measuring renal function using the renal tracer 99mTc(CO)3(NTA) (technetium-99m tricarbonyl-nitrilotriacetic acid). The disclosure...
US20150167097 CLASSIFIERS OF NF-kB PATHWAY ACTIVATION, DEVICES, AND METHODS OF USE THEREOF  
This disclosure relates to classifiers of NF-κB pathway activation, devices, and methods of use thereof. In certain embodiments, the disclosure relates to methods comprising measuring changes in...
US20150166989 PARTICLE-NUCLEIC ACID CONJUGATES AND THERAPEUTIC USES RELATED THERETO  
This disclosure relates to particles conjugated to therapeutic nucleic acids. In certain embodiments, the nucleic acid comprises a sequence that catalytically cleaves RNA, e.g., DNAzyme or...
US20150165009 TLR5 LIGANDS, THERAPEUTIC METHODS, AND COMPOSITIONS RELATED THERETO  
The disclosure relates to antiviral therapeutic methods and related compositions. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection by...
US20150158925 METHODS OF MANAGING GRAFT VERSUS HOST DISEASE  
This disclosure relates to the use of drugs to prevent graft versus host disease (GVHD) in a subject after, before, or during a hematopoietic stem cell transplant. In certain embodiments, the...
US20150157630 CHEMOKINE CXCR4 RECEPTOR MODULATORS AND USED RELATED THERETO  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
9045727 Virus-like particles, methods of preparation, and immunogenic compositions  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using...
US20150148407 OPTOGENETIC INHIBITION OF OVERACTIVE NEURONAL ACTIVITY  
This disclosure relates to recombinant proteins, vectors, and methods of treating neurological conditions by exposing neurons to an opsin and luciferase in the presence of a luciferin. In certain...
US20150148321 SUBSTITUTED ANDROST-4-ENE DIONES  
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds...
US20150148292 BONE MORPHOGENETIC PROTEIN PATHWAY ACTIVATION, COMPOSITIONS FOR OSSIFICATION, AND METHODS RELATED THERETO  
The disclosure relates to compounds and compositions for bone formation, fracture treatment, bone grafting, bone fusion, cartilage maintenance and repair, and methods related thereto. In certain...
9040713 Methods of managing blood sugar levels and compositions related thereto  
The disclosure relates to methods of managing blood sugar levels and compositions related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diabetes,...
9040567 BAX agonist, compositions, and methods related thereto  
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
US20150140670 KITS AND METHODS FOR DETERMINING PHYSIOLOGIC LEVEL(S) AND/OR RANGE(S) OF HEMOGLOBIN AND/OR DISEASE STATE  
Diagnostic kits and methods configured to rapidly and non-invasively determine physiologic levels of hemoglobin. A diagnostic kit may include a chamber pre-filled with an indicator, the indicator...
9035028 Temperature sensitive conjugate compositions  
This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a...
US20150133522 MANIPULATING MICRORNA FOR THE MANAGEMENT OF NEUROLOGICAL DISEASES OR CONDITIONS AND COMPOSITIONS RELATED THERETO  
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of...
9029561 TRKB agonists and methods of use  
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-dihydroxyflavone derivative with modified flavone or heterocyclic ring to...
US20150125057 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR IMAGING AND DETERMINING INFORMATION ASSOCIATED WITH REGIONS OF THE BRAIN  
Methods, systems and computer-readable storage mediums relate to imaging techniques of a region, for example, the brain, with magnetization transfer contrast (MTC°) effects with less specific...
D728800 Surgical arm support  
US20150110723 QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO  
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or...
8989462 Systems, methods and computer readable storage mediums storing instructions for applying multiscale bilateral filtering to magnetic resonance (RI) images  
Systems, methods and computer-readable storage mediums relate to segmenting MR images using multiscale bilateral filtering. Before the multiscale bilateral filtering, the MR images are transformed...
US20150072420 THERAPEUTIC USE OF CD31 EXPRESSING CELLS  
As described below, the present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.
US20150071987 IMMUNOSTIMULATORY COMPOSITIONS, PARTICLES, AND USES RELATED THERETO  
In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition...
8975428 Dirhodium catalyst compositions and synthetic processes related thereto  
This disclosure relates to compositions comprising dirhodium catalysts and uses related thereto, e.g., in enantioselective transformations of donor/acceptor carbenoids. In certain embodiments, the...
US20150065526 OVERCOMING ACQUIRED RESISTANCE TO CHEMOTHERAPY TREATMENTS THROUGH SUPPRESSION OF STAT3  
This disclosure relates to methods of treating cancer comprising administering an effective amount of a STAT3 inhibitor, prodrugs, or derivatives thereof, in combinations with an EGFR tyrosine...
US20150064286 PREPARATION AND COMPOSITIONS OF HIGHLY BIOAVAILABLE ZEROVALENT SULFUR AND USES THEREOF  
The present invention features sulfur-rich compositions and preparations thereof that are safe and effective as hydrogen sulfide prodrugs of high bioavailability. The invention also includes...
8969381 Chemokine CXCR4 receptor modulators and used related thereto  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
8969327 Substituted androst-4-ene diones  
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds...
US20150057263 Quinazoline Compounds And Their Use In Therapy  
This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in...
8965071 Assessing tumor response to therapy  
Systems, methods and computer program products identify first biologic data in a region of interest in a first image and calculate a first biologic volume histogram from the first biologic data....
8951515 Modified factor VIII  
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
8950344 Surgical support device  
A surgical support device can provide members for attaching various medical accessories in a safe, stable and secure manner. The surgical support device can also configured to isolate the sterile...
US20150018275 METHODS OF IMPROVING BEHAVIORAL THERAPIES  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
US20150017137 DRUG RESISTANT IMMUNOTHERAPY FOR TREATMENT OF A CANCER  
The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic...
US20150012069 Methods for Intracardiac Surgery and Intracardiac Delivery of Therapies and Devices  
A method of performing an intracardiac procedure using controlled intermittent diastolic arrest (CIDA) to expand the chambers of the heart to a volume between about 75 to 200% of their normal...
US20150004132 COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE  
We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes,...
8921599 Processes for forming amide bonds and compositions related thereto  
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an...
US20140378736 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR GENERATING A RADIATION THERAPY TREATMENT PLAN  
Methods, systems and computer-readable storage media relate to generating a treatment plan for a patient having a patient record. The methods, systems, and the computer-readable storage medias...
8916172 MVA expressing modified HIV envelope, gag, and pol genes  
The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
US20140371518 CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20140370059 USE OF mTOR INHIBITORS TO ENHANCE T CELL IMMUNE RESPONSES  
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
US20140369956 CONJUGATES OF GM-CSF AND IL-7, COMPOSITIONS AND METHODS RELATED THERETO  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20140364712 NANOENHANCED HEMOSTATIC DEVICE AND METHODS FOR MAKING A LAYER HAVING HEMOSTATIC PROPERTIES  
Devices and methods relate to inducing or promoting hemostasis. The hemostasis device may include a support layer having a first surface and an opposing second surface. The device may include a...
US20140350129 DIAGNOSTIC ASSAY TO PREDICT CARDIOVASCULAR RISK  
This invention relates to the area of cardiovascular disorders and specifically relates to methods of diagnostic tests using a combination of markers to predict an individual's risk for developing...
US20140350016 POTENT AND SELECTIVE INHIBITORS OF HEPATITIS C VIRUS  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
US20140349984 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20140348851 ANTIBODIES DIRECTED AGAINST INFLUENZA  
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly...
US20140348781 CONJUGATES OF GM-CSF AND IL-9, COMPOSITIONS AND METHODS RELATED THERETO  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-9 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-9 are...