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Patents and Patent Applications from Emory University


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8989462 Systems, methods and computer readable storage mediums storing instructions for applying multiscale bilateral filtering to magnetic resonance (RI) images  
Systems, methods and computer-readable storage mediums relate to segmenting MR images using multiscale bilateral filtering. Before the multiscale bilateral filtering, the MR images are transformed...
US20150072420 THERAPEUTIC USE OF CD31 EXPRESSING CELLS  
As described below, the present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.
US20150071987 IMMUNOSTIMULATORY COMPOSITIONS, PARTICLES, AND USES RELATED THERETO  
In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition...
8975428 Dirhodium catalyst compositions and synthetic processes related thereto  
This disclosure relates to compositions comprising dirhodium catalysts and uses related thereto, e.g., in enantioselective transformations of donor/acceptor carbenoids. In certain embodiments, the...
US20150065526 OVERCOMING ACQUIRED RESISTANCE TO CHEMOTHERAPY TREATMENTS THROUGH SUPPRESSION OF STAT3  
This disclosure relates to methods of treating cancer comprising administering an effective amount of a STAT3 inhibitor, prodrugs, or derivatives thereof, in combinations with an EGFR tyrosine...
US20150064286 PREPARATION AND COMPOSITIONS OF HIGHLY BIOAVAILABLE ZEROVALENT SULFUR AND USES THEREOF  
The present invention features sulfur-rich compositions and preparations thereof that are safe and effective as hydrogen sulfide prodrugs of high bioavailability. The invention also includes...
8969381 Chemokine CXCR4 receptor modulators and used related thereto  
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising compounds disclosed...
8969327 Substituted androst-4-ene diones  
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds...
US20150057263 Quinazoline Compounds And Their Use In Therapy  
This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such compounds as medicaments, in...
8965071 Assessing tumor response to therapy  
Systems, methods and computer program products identify first biologic data in a region of interest in a first image and calculate a first biologic volume histogram from the first biologic data....
8951515 Modified factor VIII  
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
8950344 Surgical support device  
A surgical support device can provide members for attaching various medical accessories in a safe, stable and secure manner. The surgical support device can also configured to isolate the sterile...
US20150018275 METHODS OF IMPROVING BEHAVIORAL THERAPIES  
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of...
US20150017137 DRUG RESISTANT IMMUNOTHERAPY FOR TREATMENT OF A CANCER  
The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic...
US20150012069 Methods for Intracardiac Surgery and Intracardiac Delivery of Therapies and Devices  
A method of performing an intracardiac procedure using controlled intermittent diastolic arrest (CIDA) to expand the chambers of the heart to a volume between about 75 to 200% of their normal...
US20150004132 COMPOSITIONS AND METHODS FOR GENERATING AN IMMUNE RESPONSE  
We have developed DNA and viral vectors that can be used, alone or in combination, as a vaccine against one HIV clade, subtype, or recombinant form of HIV or against multiple HIV clades, subtypes,...
8921599 Processes for forming amide bonds and compositions related thereto  
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an...
US20140378736 METHODS, SYSTEMS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR GENERATING A RADIATION THERAPY TREATMENT PLAN  
Methods, systems and computer-readable storage media relate to generating a treatment plan for a patient having a patient record. The methods, systems, and the computer-readable storage medias...
8916172 MVA expressing modified HIV envelope, gag, and pol genes  
The invention provides modified virus Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
US20140371518 CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20140370059 USE OF mTOR INHIBITORS TO ENHANCE T CELL IMMUNE RESPONSES  
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
US20140369956 CONJUGATES OF GM-CSF AND IL-7, COMPOSITIONS AND METHODS RELATED THERETO  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
US20140364712 NANOENHANCED HEMOSTATIC DEVICE AND METHODS FOR MAKING A LAYER HAVING HEMOSTATIC PROPERTIES  
Devices and methods relate to inducing or promoting hemostasis. The hemostasis device may include a support layer having a first surface and an opposing second surface. The device may include a...
US20140350129 DIAGNOSTIC ASSAY TO PREDICT CARDIOVASCULAR RISK  
This invention relates to the area of cardiovascular disorders and specifically relates to methods of diagnostic tests using a combination of markers to predict an individual's risk for developing...
US20140350016 POTENT AND SELECTIVE INHIBITORS OF HEPATITIS C VIRUS  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
US20140349984 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20140348851 ANTIBODIES DIRECTED AGAINST INFLUENZA  
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly...
US20140348781 CONJUGATES OF GM-CSF AND IL-9, COMPOSITIONS AND METHODS RELATED THERETO  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-9 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-9 are...
US20140341756 METHODS, DEVICES, AND SYSTEMS FOR MOVING A FLUID ALONG A FLUID PATH FOR TREATMENT  
The devices and systems are medical fluid treatment therapies. The device and systems are configured and capable of operating based on small volumes of fluids. The devices and systems include a...
8889705 Noscapine analogs and their use in treating cancers  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are noscapine analogs. The compounds and compositions can be...
8889430 Nanostructures, methods of synthesizing thereof, and methods of use thereof  
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an...
US20140336968 METHOD AND APPARATUS FOR CALIBRATING A MAGNETIC SENSOR  
A magnetic sensor is calibrated by acquiring magnetic field measurements, fitting at least part of the plurality of magnetic field measurements to an ellipsoid model to obtain a coordinate of a...
US20140336143 TREATMENT OF EBV AND KHSV INFECTION AND ASSOCIATED ABNORMAL CELLULAR PROLIFERATION  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
US20140336071 DEVICES, COMPOSITIONS, AND METHODS FOR MEASURING MOLECULES AND FORCES  
This disclosure relates to compositions, devices and methods of detecting the presence of molecules and optionally quantifying forces associated with molecular interactions on the surface of cells...
US20140335606 PURIFICATION OF STEM CELL-DERIVED CARDIOMYOCYTES USING MOLECULAR BEACONS TARGETING CARDIOMYOCYTE SPECIFIC mRNA  
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular...
US20140335079 SOLENOPSIN AND DERIVATIVES, THERAPEUTIC COMPOSITIONS, AND METHODS RELATED THERETO  
This disclosure relates to solenopsin derivatives, pharmaceutical compositions, and therapeutic uses related thereto. In certain embodiments, the disclosure relates to compounds of the following...
US20140329907 CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS  
Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a...
US20140329817 MYXOVIRUS THERAPEUTICS, COMPOUNDS, AND USES RELATED THERETO  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the...
US20140329716 DEVICES HAVING A CALIBRATION CONTROL REGION, SYSTEMS AND METHODS FOR IMMUNOHISTOCHEMICAL ANALYSES  
The disclosure relates to devices, systems and methods that address the variability in immunohistochemistry (IHC) tests that can lead to inaccurate diagnosis or misdiagnosis while maintaining...
US20140328793 ANTIVIRAL JAK INHIBITORS USEFUL IN TREATING OR PREVENTING RETROVIRAL AND OTHER VIRAL INFECTIONS  
Compounds, compositions, and methods of treatment and prevention of HIV infection are disclosed. The compounds are pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidine JAK inhibitors. Combinations...
8871268 Biodegradable polymeric networks and methods for manufacturing the same  
Methods of manufacturing a three-dimensional, biodegradable, thermoset polymeric network composition having desirable degradation and mechanical properties, comprising a macromer component...
US20140309280 ASSAYS FOR MICRO-RNA-182 AS A BIOMARKER FOR MUSCLE ATROPHY AND THERAPEUTIC APPLICATIONS  
In certain embodiments, this disclosure relates to assays for miR-182 and therapeutic applications. In certain embodiments, the disclosure relates to methods of evaluating a state of skeletal...
US20140309275 Sphingosine Analogs, Compositions, and Methods Related Thereto  
The disclosure relates to compounds, pharmaceutical compositions, and methods of treating or preventing disease. In certain embodiments, the disclosure relates to methods of treating an infection...
8859595 Potent and selective inhibitors of hepatitis C virus  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
8858489 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20140294818 PGAM1 INHIBITORS AND METHODS RELATED THERETO  
In certain embodiments, the disclosure relates to methods of treating or preventing a PGAM1 mediated condition such as cancer or tumor growth comprising administering an effective amount of PGAM1...
US20140294764 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO  
This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered...
8846624 Modified protein polymers  
In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the...
US20140288013 METHODS AND COMPOSITIONS FOR THE MANAGEMENT OF CANCER USING 2-DG AND AN IGF-IR INHIBITOR  
The disclosure relates to methods and compositions for the management of cancer. In certain embodiments, the disclosure relates to methods of treating or preventing cancer by administering an...
8841317 Noscapine and analogs and methods related thereto  
The invention relates to the innate immune pathway and anti-inflammatory molecules with therapeutic properties. In some embodiments, the invention relates to compounds and pharmaceutical...