Patents and Patent Applications from Emory University


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9512184 Hepatitis C virus particles, vaccines, compositions and methods related thereto  
This disclosure relates to viral particles and nucleic acids encoding an HCV envelope glycoprotein 2 containing a mutation. Viral particles can be created and administered to a subject to illicit...
9511071 Compounds and compositions for ossification and methods related thereto  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
9510948 Systems, devices and methods for repair of heart valve lesions  
The systems and devices and methods relate to surgical and percutaneous repair of heart valve regions. The systems and devices are structured to conform to the desired shape of a specific patient....
US20160348077 FUSION PROTEIN FOR INDUCING PLURIPOTENT STEM CELLS AND APPLICATION METHOD THEREOF  
Provided is a protein coded by a gene related to cell totipotency and a transcriptional activation domain of a mammalian YAP protein or a fusion protein of a segment with a transcriptional control...
9504674 TrkB agonists and methods of use  
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-dihydroxyflavone derivative with modified flavone or heterocyclic ring to...
US20160340437 Methods for Managing Sepsis  
This disclosure relates to methods of treating or preventing sepsis, severe sepsis, or septic shock comprising administering an effective amount of a 2B4 antibody, a CD48 variant, a CD48 antibody...
9499489 Myxovirus therapeutics, compounds, and uses related thereto  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the...
US20160335257 Methods, Systems and Computer Readable Storage Media for Determining Relevant Documents Based On Citation Information  
Methods, systems and computer-readable storage media relate to automatically and efficiently determine a set of relevant document(s) relevant to an inputted set of document(s) based on at least...
9493742 Purification of cell mixtures using molecular beacons targeting cell specific RNA  
This disclosure is in the area of research and therapeutics. In certain embodiments, it provides methods to assist in the purification of cell mixtures, e.g., cardiomyocytes, using molecular...
US20160327573 Methods for Diagnosing Onset and Monitoring Progression of Huntington's Disease  
The present invention relates to methods of diagnosing onset, monitoring progression and initiating therapies for a neurological disorder, such as juvenile- or adult-onset Huntington's disease, by...
US20160324834 Use of mTOR Inhibitors to Enhance T Cell Immune Responses  
It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T...
9486643 Methods, systems and computer readable storage media storing instructions for image-guided treatment planning and assessment  
Methods, systems and computer-readable storage media relate to image-guided treatment planning and treatment assessment. The methods, systems, and the computer-readable storage medias according to...
US20160318985 Chimeric Virus-Like Particles Incorporating Fusion GPI Anchored GM-CSF and IL-4 Conjugates  
This disclosure relates to a GM-CSF and IL-4 conjugate fused to a glycolipid (GPI)-anchoring sequence that is incorporated into chimeric virus-like particles (VLPs) enriched with a viral protein,...
US20160317793 CONDUIT DEVICE AND SYSTEM FOR IMPLANTING A CONDUIT DEVICE IN A TISSUE WALL  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
US20160317474 Managing Visual Dysfunction or Loss of Vision for Diabetic Subjects  
This disclosure relates to managing diabetes induced visual dysfunctions or vision loss by altering levels of dopamine. In certain embodiments, the disclosure relates to methods of treating or...
US20160317473 METHODS OF TREATING OR PREVENTING BRAIN DAMAGE DUE TO HYPOXIC-ISCHEMIA  
This disclosure relates to managing brain injury. In certain embodiments, this disclosure relates to methods comprising administering an effective amount of an inhibitor of sphingosine-1-phoshate...
US20160310608 Targeted Protease Compositions and Uses Related Thereto  
This disclosure relates to targeted protease compositions and uses related thereto. In certain embodiments, the disclosure relates to nanoparticles wherein a targeting molecule is linked to the...
US20160310604 SMALL MOLECULE LIGAND-DRUG CONJUGATES FOR TARGETED CANCER THERAPY  
The present invention describes small molecule ligand-drug conjugates and methods of using the small molecule ligand-drug conjugates for targeted treatment of cancer in a patient in need thereof....
US20160310511 Myxovirus Therapeutics, Compounds, and Uses Related Thereto  
This disclosure relates to antiviral compounds disclosed herein and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical compositions. Typically, the...
US20160310417 Formulations and Methods For Targeted Ocular Delivery of Therapeutic Agents  
Formulations, systems, and methods of administration are provided for preferential targeted delivery of drug to ocular tissue. In embodiments, the formulation may include a non-Newtonian fluid...
US20160304567 METHODS AND COMPOSITIONS FOR THE DISPLAY OF POLYPEPTIDES ON THE PILI OF GRAM- POSITIVE BACTERIA  
Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of...
9469685 Antibodies directed against influenza  
Antibodies or antibody fragments, wherein the antibody or the fragment binds HA domain of influenza virus (e.g. H1N1, H5N1, or both). Also described are cloned human antibodies that bind influenza.
9458458 Manipulating microRNA for the management of neurological diseases or conditions and compositions related thereto  
This disclosure relates to manipulating microRNA for the management of neurological disorders and compositions related thereto. In certain embodiments, the disclosure contemplates inhibition of...
9458226 Recombinant antibodies against H1N1 influenza  
Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice challenged with a lethal dose of swine...
9458217 Methods of managing graft versus host disease  
This disclosure relates to the use of drugs to prevent graft versus host disease (GVHD) in a subject after, before, or during a hematopoietic stem cell transplant. In certain embodiments, the...
9458131 Compounds and compositions used to epigenetically transform cells and methods related thereto  
This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered...
9457080 Methods and compositions for the treatment of persistent infections and cancer by inhibiting the programmed cell death 1 (PD-1) pathway  
The present invention provides methods and compositions for the treatment, prevention, or reduction of persistent infections, such as chronic infections, latent infections, and slow infections and...
9453239 Recombinant MVA viruses expressing clade A/G, clade B, and clade C modified HIV env, gag and pol genes  
The invention provides modified vaccinia Ankara (MVA), a replication-deficient strain of vaccinia virus, expressing human immunodeficiency virus (HIV) env, gag, and pol genes.
9451882 Integrated system and methods for real-time anatomical guidance in a diagnostic or therapeutic procedure  
According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light...
US20160250326 Conjugates of GM-CSF and IL-7, and Compositions Thereof  
In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are...
9428815 HIV-1 reverse transcriptase codon deletion and its use in the management and treatment of HIV infections  
The present invention provides an isolated HIV-1 mutant and isolated nucleic acid molecules comprising HIV-RT coding sequences harboring a novel mutation in the S68 codon, and in particular,...
9428478 Piperazine derivatives, compositions, and uses related thereto  
The disclosure relates to piperazine derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidase.
US20160244403 Cyclopropyl Derivatives and Methods of Use  
The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions...
US20160243534 Heterocyclic Coupling Catalysts and Methods Related Thereto  
This disclosure relates to synthetic coupling methods using a catalytic molecule comprising two bonded atoms wherein one atom is an amide nitrogen and the second atom is not nitrogen or carbon,...
US20160243121 Quinazoline Derivatives, Compositions, and Uses Related Thereto  
The disclosure relates to quinazoline derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to inhibitors of NADPH-oxidases (Nox enzymes) and/or...
US20160242745 Systems, Methods and Computer Readable Storage Media Storing Instructions for Image-Guided Interventions Based on Patient-Specific Models  
Systems, methods, and computer-readable storage media relate to generate an integrated image based on strain data and elastic model. The method may include determining, by a processor, a range of...
9421238 Treatment of klebsiella pneumoniae with liposomally formulated glutathione  
The composition of the invention, liposomal glutathione, has been recently shown to have utility for having an antibiotic like effect on Klebsiella pneumonia cultures in vitro, and in vivo as...
US20160235765 Methods of Managing Eye Pain and Compositions Related Thereto  
This disclosure relates to methods of managing eye pain, for example, due to eye surgery. In certain embodiments, the disclosure relates to methods comprising administering a local anesthetic in...
US20160235439 Devices, Systems, and Methods for Improving Access to Cardiac and Vascular Chambers  
Devices, systems and methods are provided for enhancing mechanical strength of tissue, allowing direct and secure access to cardiac and vascular structures, either through tiny incisions or...
US20160228533 Use of EGFR Pathway Inhibitors to Increase Immune Responses to Antigens  
This disclosure relates to using EGFR pathway inhibitors in combination with compositions comprising an antigen to increase, elicit, or improve an antigen or vaccine-induced immune response. In...
US20160228466 Glutamate Dehydrogenase 1 Inhibitors and Methods of Treating Cancer  
This disclosure relates to methods of treating or preventing cancer comprising administering an effective amount of a glutamate dehydrogenase 1 inhibitor to a subject in need thereof. In certain...
US20160220595 NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO  
This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside...
9402850 BAX agonist, compositions, and methods related thereto  
The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer,...
US20160213691 Treating Various Disorders Using TrkB Agonists  
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
US20160202252 Devices and Methods Related to Airway Inflammation  
This disclosure relates to devices, assays, and methods related to airway inflammation caused by polymorphonuclear neutrophils (PMNs). In certain embodiments, the disclosure relates to a model...
US20160200800 ANTIBODIES DIRECTED AGAINST INFLUENZA  
Antibodies that specifically bind influenza virus hemagglutinin A (HA), and antigen binding fragments thereof are disclosed herein. In several embodiments, these antibodies are broadly...
US20160199337 Nutritional Formulas Comprising Medium Chain Fatty Acids or Esters Thereof and Methods Related Thereto  
This disclosure relates to nutritional formulas and uses for treating or preventing a gastrointestinal condition and/or motor-planning speech and/or coordinator difficulties. In certain...
US20160194351 Progesterone Phosphate Analogs and Uses Related Thereto  
This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing...
9382286 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
9382193 Processes for forming amide bonds and compositions related thereto  
The disclosure relates to methods for producing amide bonds and reagents related thereto. In some embodiments, the disclosure relates to methods of producing an amide comprising mixing an...