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6107281 |
Compounds and their combinations for the treatment of influenza infection
Administration of one or more of glutathione, its disulfide dimer, ascorbate-2-phosphate, or N-acetyl-L-cysteine, with or without antioxidants, is suitable for the treatment of influenza virus...
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6093699 |
Method for gene therapy involving suppression of an immune response
A method for specifically suppressing the capacity of a mammal receiving gene therapy to mount an immune response to a given expressed gene of the deficient gene in question, which response is...
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6086525 |
Magnetic nerve stimulator for exciting peripheral nerves
A magnetic nerve stimulator system is comprised of a core constructed from a material having a high field saturation with a coil winding. A thyrister capacitive discharge circuit pulses the device....
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6083167 |
Systems and methods for providing radiation therapy and catheter guides
A system and method for the prevention of restenosis uses a source of radiation to treat the blood vessel. An intra-vascular ultrasound system acquires precise two-dimensional images of a treatment...
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6077662 |
Virus-like particles, methods and immunogenic compositions
The present disclosure provides retrovirus-like particles which comprise retrovirus env proteins, immunogenic compositions comprising retrovirus-like particles, methods for the production of...
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6071922 |
Synthesis, anti-human immunodeficiency virus, and anti-hepatitis B virus activities of 1,3-oxaselenolane nucleosides
A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an...
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6071532 |
Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof
The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a...
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6069252 |
Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
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6066628 |
Non-iron metalloporphyrins and methods of use
The present disclosure provides novel non-iron metalloporphyrins, especially those porphyrin complexes containing gallium or indium as the metal ion, and antibacterial compositions comprising...
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6064906 |
Method, system and apparatus for determining prognosis in atrial fibrillation
A system, apparatus and method for determining prognosis in atrial fibrillation non-invasively detects electrical activity of the heart with external electrodes, such as with ECG leads. The...
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6060643 |
Mouse model with human immune system
The present invention provides a non-human genetically immunodeficient mammal the peripheral blood of which contains a non-lethal percent of T-cells of human origin which is at least 20% as well as...
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6042538 |
Device for endoscopic vessel harvesting
A endoscopic device provides improvements in the endoscopic working space by the use of a semi-tubular hood with an arched top wall and self-supporting walls that allow simultaneous manipulations...
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6037332 |
Method of urinary bladder instillation
Growth of transition cell carcinoma cells is found to be inhibited by dextran sulfate. Intravesicular instillation of a dextran sulfate solution prevents growth of bladder carcinoma cells. Dextran...
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6024740 |
Circumferential ablation device assembly
This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation...
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6019974 |
SPE-4 peptides
This application discloses SPE-4 related peptides, peptide-carrier protein conjugates and fusion proteins, immunogenic compositions, antibodies and methods for characterizing the SPE-4 related...
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6013858 |
Mouse lacking heart-muscle adenine nucleotide translocator protein and methods
Provided are transgenic mice genetically engineered for a deficiency of the heart-skeletal muscle isoform of the adenine nucleotide translocator protein (Ant1). These mice exhibit histological,...
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6013632 |
Compounds and their combinations for the treatment of influenza infection
Administration of one or more of glutathione, its disulfide dimer, ascorbate-2-phosphate, or N-acetyl-L-cysteine, with or without antioxidants, is suitable for the treatment of influenza virus...
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6012926 |
Virtual reality system for treating patients with anxiety disorders
A virtual reality system provides effective exposure treatment for psychiatric patients suffering from a particular anxiety disorder. The system is characterized by a video screen disposed in front...
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5998624 |
Haloisoquinoline carboxamide
Compounds of the invention have the general structure ##STR1## X, Y or Z are, respectively independently, H, F or an isotope thereof, Br or an isotope thereof, I or an isotope thereof, At or an...
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5990341 |
Diastereoselective synthesis hydroxyethylene dipeptide isosteres
A process for the synthesis of hydroxyethylene dipeptide isosteres from α-N,N-di(protected)amino(alkyl or substituted alkyl) methyl ketones that can be efficiently carried out on an industrial ...
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5990093 |
Treating HBV with phospholipid prodrugs of β-L-2',3'-dideoxyadenosine 5'-monophosphate
A method for treating HBV infections comprising administering a 5'-phospholipid prodrug of β-L-2',3'-dideoxyadenosine 5'-monophosphate.
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5986074 |
Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These...
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5985307 |
Device and method for non-occlusive localized drug delivery
A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device provides a means for locally delivering a substance into the boundary layer of fluid...
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5981247 |
Recombinant hepatitis C virus RNA replicase
A recombinant RNA-dependent RNA polymerase of hepatitis C virus (r-HCV-RDRP) coding DNA was cloned and expressed yielding active enzyme in vitro. The r-HCV-RDRP can include up to 20 added amino...
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5976536 |
Neisseria mutants, lipooligosaccharides and immunogenic compositions
Provided herein are mutant strains of Neisseria meningitidis which produce lipooligosaccharide (LOS) differing from the wild-type LOS in structure as well as the mutant LOS molecules and...
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5969094 |
Anti-paramyxovirus screening method and vaccine
A method is provided for detecting whether a test composition can inhibit cell fusion mediated by paramyxovirus infection. A method is also provided for identifying an antiviral peptide capable of...
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5959014 |
Water-stabilized organosilane compounds and methods for using the same
The product of reacting an organosilane optionally having a nonhydrolizable organic group, but having one or more hydrolyzable groups, with a polyol containing at least three hydroxy groups, where...
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5955053 |
Metal chelates as pharmaceutical imaging agents, processes of making such and uses thereof
The present invention relates to novel metal chelates, exemplified as technetium-99m or rhenium chelates, and to the process of preparing such metal chelates from corresponding ligands. These...
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5939276 |
Flow cytometry assay for heparin-induced thrombocytopenia
The present invention relates to a flow cytometry assay for the determination of heparin-induced thrombocytopenia. This method (a) detects in a plasma sample the presence of anti-heparin antibodies...
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5932715 |
Nucleotide sequences encoding a CS2 pilin protein
Provided herein is a nucleotide sequence encoding a CS2 pilin protein of enterotoxigenic Escherichia coli. Also provided herein are the nucleotide sequences of coding sequences linked to the CS2...
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5925643 |
Enantiomerically pure β-D-dioxolane-nucleosides
A method and composition for the treatment of humans infected with HIV that includes the administration of an HIV treatment amount of an enantiomerically pure β-D-dioxolanyl purine nucleoside of ...
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5919797 |
Halogenated naphthyl methoxy piperidines for mapping serotonin transporter sites
Halogenated naphthyl methoxy piperidines having a strong affinity for the serotonin transporter are disclosed. Those compounds can be labeled with positron-emitting and/or gamma emitting halogen...
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5919158 |
Method and apparatus for preventing and clearing condensation on the lens during a fluid-gas exchange portion of a pars plana vitrectomy
An infusion cannula for use in clearing and preventing condensation on the posterior surface of an artificial lens during the fluid-gas exchange portion of a pars plana vitrectomy is described. The...
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5916560 |
Methods for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways and compositions for use therewith
The present invention provides a method for inhibiting an immune reponse and a method for inhibiting rejection of transplanted tissues. This method comprises preventing an endogenous molecule on a...
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5914400 |
Method and compositions for the synthesis of BCH-189 and related compounds
The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic...
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5914331 |
Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of...
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5905070 |
5--Caboxamido or 5--fluoro!-- 2', 3'--unsaturated or 3'--modified!--pyrimidine nucleosides
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a 5-carboxamido or...
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5899882 |
Catheter apparatus for radiation treatment of a desired area in the vascular system of a patient
Apparatus and method are described for delivery of a treating element, such as a radiation source, through a catheter to a desired site in the intraluminal passageways of a patient, such as a...
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5892025 |
Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that referentially catalyzes a reaction in one of the...
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5888974 |
Hybrid human/animal factor VIII
A hybrid procoagulant factor VIII is produced by isolation and recombination of human and other nonhuman mammalian factor VIII subunits or domains, or by genetic engineering of the human and animal...
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5888475 |
Labeled cocaine analogs
Novel methods for positron emission tomography or single photon emission spectroscopy using tracer compounds having the structure: ##STR1## where X in β configuration is phenyl, naphthyl; 2,3 or ...
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5877203 |
Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of...
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5872107 |
Treatment of urogenital cancer with boron neutron capture therapy
Methods and compositions for treating urogenital tumors, and in particular, cancer of the prostate, bladder, and kidney, with BCNT, are disclosed. Any boron-containing compound that is sufficiently...
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5865766 |
Multichannel, multipurpose sample collection and drug delivery system for laboratory animals
A multichannel, multipurpose sample collection and drug delivery system for laboratory animals includes several sampling and/or infusion devices mounted on a powered turntable above the cage but...
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5864038 |
Labeled cocaine analogs
Novel compounds having the structure: ##STR1## where X in β configuration is phenyl, naphthyl; 2,3 or 4-iodophenyl; 2,3 or 4-(trimethylsilyl)phenyl; 3,4,5 or 6-iodonaphthyl; 3,4,5 or ...
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5859204 |
Modified factor VIII
Site-specific replacement of amino acids in the region of positions 484-509 of human factor VIII can result in reduction of reactivity to an inhibitory antibody while procoagulant activity is...
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5852027 |
Antiviral 1,3-dioxolane nucleoside analogues
This invention includes the compounds 2'-deoxy-5-fluoro-3'-oxacytidine, (-)-2'-deoxy-5-fluoro-3'-oxacytidine, and (+)-2'-deoxy-5-fluoro-3+-oxacytidine, and pharmaceutically acceptable salts thereof...
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5846959 |
Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration...
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5834474 |
Enantiomerically pure B--D--dioxolane nucleosides with selective anti-hepatitus B virus activity
A method and composition for the treatment of humans infected with HBV that includes the administration of an HBV treatment amount of a β-dioxolanyl purine nucleoside of the formula: ##STR1## ...
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5832878 |
Apparatus permitting tethered laboratory animals to move freely
A multichannel, multipurpose sample collection and drug delivery system for freely-moving laboratory animals includes several sampling and/or infusion devices mounted on a powered turntable above...
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