Patents and Patent Applications from Emory University


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7563775 Insulin-responsive DNA binding protein-1 and methods to regulate insulin-responsive genes  
The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 (IRDBP-1) and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that...
US20090181397 PREDICTIVE AND DIAGNOSTIC METHODS FOR CANCER  
The present disclosure encompasses methods of diagnosing the presence of a cancer, and particularly a cancer of prostate or breast tissue, in a human subject, predicting the outcome or severity of...
7560107 Modified factor VIII  
Modified porcine factor VIII is disclosed in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful for treatment of...
US20090176745 TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
7557139 Triptolide analogs for the treatment of autoimmune and inflammatory disorders  
The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of...
US20090169861 POROUS MATERIALS EMBEDDED WITH NANOSPECIES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
7550299 Method for predicting onset/risk of atrial fibrillation (AF)  
A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a...
US20090149416 2' and 3'-Substituted Cyclobutyl Nucleoside Analogs for the Treatment Viral Infections and Abnormal Cellular Proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
7544715 Tumor imaging compounds  
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB)...
7537902 Methods and kits using a molecular interaction between a Smurf-1 WW domain and LIM mineralization protein isoforms  
The instant application provides kits and methods for identifying agents which induce or inhibit the osteogenic effect of LMP or BMP proteins. The kits are directed to methods which measure either...
US20090130034 RE-ENGINEERED UV DAMAGE ENDONUCLEASE, COMPOSITIONS AND METHODS  
Provided are methods and compositions for reducing damage to skin by ultraviolet light and other agents that cause distortion to double stranded DNA and methods for reducing damage to other organs...
US20090123365 Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof  
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a...
7524936 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
US20090105181 Modulation of sodium channels by nicotinamide adenine dinucleotide  
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the...
US20090099194 CXCR4 Antagonists Including Diazine And Triazine Structures For The Treatment Of Medical Disorders  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
7517866 LIM mineralization protein splice variants  
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
US20090092998 MARKER FOR ARRHYTHMIA RISK  
The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an individual. By using the markers of the present invention, individual with high risk of...
7504374 Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2  
The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic...
US20090054313 METHOD FOR INDUCING DEPOSITION AND MATURATION OF BONE COMPRISING A CO-THERAPEUTIC REGIMEN OF LMP-1 AND BMP-2  
The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic...
7495006 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
US20090042195 METHODS AND SYSTEMS FOR SCREENING FOR AND DIAGNOSING DNA METHYLATION ASSOCIATED ABNORMALITIES AND SEX CHROMOSOME ANEUPLOIDIES  
Methods and systems for population screening and diagnostics are provided. In particular methods and systems for population screening of individuals for genetic disorders due to alterations in DNA...
US20090035827 O-acetyltransferase from Neisseria Meningitidis, Compositions and Methods  
Provided are recombinant DNA molecules that do not occur in nature encoding a Lot3 O-acetyltransferase, vectors that direct expression of a Lot O-acetyltransferase, recombinant host cells which...
US20090023791 PH-dependent NMDA receptor antagonists  
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neurprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events...
US20090018209 CURCUMIN AND CURCUMINOID INHIBITION OF ANGIOGENESIS  
Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin,...
US20090018167 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states  
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit...
US20090011991 Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis  
The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. Conjugates for...
7473687 Methods for the treatment of a traumatic central nervous system injury  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20080318914 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
7468436 Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
7468357 Nucleosides with anti-hepatitis B virus activity  
A method for the treatment of a host, and in particular, a human, infected with hepatitis B virus (HBV) is provided that includes administering an effective amount of a β-L-nucleotide, optionally...
US20080312279 Compositions for Treating Fragile X and Other Disorders Methods of Use Thereof, and Screening for Compounds for Fragile X and Other Disorders  
Methods of screening compounds, active compositions, pharmaceutical compositions, methods of treating disorders, methods of preventing disorders, and kits to screen a library of compounds, are...
US20080306326 Drive Circuit For Magnetic Stimulation  
The inventive technique includes devices and methods for generating a magnetic field. One such device may include an inductor for generating a magnetic field and a power source for providing...
US20080300298 Honokiol Derivates For the Treatment of Proliferative Disorders  
The present invention provides novel honokiol derivatives, as well as pharmaceutical compositions containing the honokiol derivatives. These compounds and pharmaceutical compositions can be used...
7459145 Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring  
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and...
US20080292599 Chondrogenic Compositions and Methods of Use  
The invention provides a method of treatment joint and disk disease comprising administering to the subject in need thereof a novel composition comprising a substantially purified plurality of...
7452530 Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway  
This invention provides methods of inducing an antiviral response in an individual comprising administering to the individual an effective amount of a LT-B blocking agent and a pharmaceutically...
US20080280846 2', 3'-DIDEOXYNUCLEOSIDE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE INFECTIONS  
A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an...
US20080280294 Inherited Mitochondrial Dna Mutations in Cancer  
A method is provided for identifying a subject likely to have, or at risk of developing a disease condition correlated with increased reactive oxygen species (ROS), including cancer, by...
7450063 Method and arrangements relating to satellite-based positioning  
Alleviating ambiguous pseudorange reconstruction in connection with satellite-based positioning of mobile terminals with assistance data such as Assisted GPS (AGPS). An initial pseudorange...
US20080275016 FULVENE AND FULVALENE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and...
US20080268445 Ant2 Conditional Knockout Mouse and Methods  
Described are methods for inactivating adenine nucleotide transporter proteins in specific tissues of a transgenic nonhuman animal using a conditional knockin/knockout technology such as the...
US20080268013 Polyethylene Oxide Polymers Including Anti-Inflammatory Glycodendrons  
Poly(ethylene oxide) (PEO) glycodendrimers can serve as multivalent inhibitors of selectin-mediated leukocyte recruitment regulating inflammatory response. Disclosed are compounds and methods...
7439351 2′ or 3′ -deoxy and 2′, 3′-dideoxy-β-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents  
Method for the sterospecific preparation of 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentafuranonucleoside compounds. 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentofuranonucleoside compounds are also...
7439221 Methods and compositions for modulating gamete adhesion  
Methods and compositions for modulating mammalian gamete adhesion are provided. Representative modulators of gamete adhesion include, but are not limited to polypeptides comprising at least one...
US20080254001 Novel bone mineralization protein expression systems, and methods of studying their intracellular signaling pathways  
The present invention is directed to methods of switching a differentiation of a cell from a non-osteogenic lineage into an osteogenic lineage. The present invention is also directed to methods of...
7432303 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states  
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit...
7432052 Method and identification of downstream mRNA ligands to FMRP and their role in fragile X syndrome and associated disorders  
Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for...
US20080241807 Apparatuses and Methods for Simulating Microlaryngeal Surgery  
Apparatus for simulating microlaryngeal surgery. In one embodiment, the apparatus includes a larynx model that emulates an actual larynx, the larynx model including an inner passage that includes...
7429560 Ketoamide inhibitors in chronic nerve disease  
Compositions and methods for treating neural pathologies are provided. In particular, compositions and methods for treating neural pathologies including axonal degeneration are provided. The...
US20080234320 CURCUMIN ANALOGS WITH ANTI-TUMOR AND ANTI-ANGIOGENIC PROPERTIES  
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.