Patents and Patent Applications from Emory University


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7807181 Neisseria mutants, lipooligosaccharides and immunogenic compositions  
Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A...
US20100249172 9-CHLORO NOSCAPINE AND ITS USE IN TREATING CANCERS, INCLUDING DRUG-RESISTANT CANCERS  
9-Chloro-nos, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-chloro-nos, and methods of preparation and use thereof are...
US20100249122 Kinase Inhibitors for Preventing or Treating Pathogen Infection and Method of Use Thereof  
The present invention provides compositions and methods of use thereof to prevent and/or treat pathogenic infection. In particular, the present invention provides the use of kinase inhibitors to...
US20100239545 Methods of expressing LIM mineralization protein in non-osseous cells  
Methods of expressing LIM mineralization protein in non-osseous mammalian cells, such as stem cells or intervertebral disc cells (e.g., cells of the annulus fibrosus, or cells of the nucleus...
7795017 DNA expression vectors and methods of use  
The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of...
US20100227878 NOSCAPINE ANALOGS AND THEIR USE IN TREATING CANCERS, INCLUDING DRUG-RESISTANT CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are noscapine analogs. The compounds and compositions can be...
7785839 Methods to manufacture 1,3-dioxolane nucleosides  
This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (−)-DAPD, suitable for large scale development, is described....
7781574 Chimeric osteogenic factor containing proteins capable of increased nuclear localization and methods of use thereof  
Compositions comprising osteogenic factors fused with membrane transduction domains of viral proteins are provided. Also provided are methods of expression and use of such compositions. Further,...
US20100204463 Preparation Of Synthetic Nucleosides via Pi-Allyl Transition Metal Complex Formation  
This invention provides highly regioselective and stereoselective processes for preparing synthetic nucleosides. A process for the preparation of synthetic nucleosides is provided that comprises...
7772208 2′,3′-dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections  
A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an...
7772185 Method for promoting axonal outgrowth in damaged nerves  
The subject invention pertains to the therapeutic use of certain GAG-degrading enzymes, and enzyme combinations, to promote nerve repair and regeneration.
US20100197954 SYNTHESIS OF SPHINGOSINES AND THEIR DERIVATIVES  
Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like.
US20100189762 TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
US20100184668 METHOD OF TREATING ABNORMAL ANGIOGENESIS VIA THE BAI FAMILY OF PROTEINS AND THEIR PROTEIN FRAGMENTS  
The present disclosure encompasses the protein BAI1, and two cleavage products thereof, Vstat120 and Vstat40. The disclosure also describes the use of BAI1, and two cleavage products thereof,...
US20100168052 Treatment of EBV and KHSV Infection and Associated Abnormal Cellular Proliferation  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
7744523 Drive circuit for magnetic stimulation  
The inventive technique includes devices and methods for generating a magnetic field. One such device may include an inductor for generating a magnetic field and a power source for providing...
US20100160296 USE OF IMIPRAMINE BLUE AND ANALOGS THEREOF IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
US20100159475 Methods For Determination of Calcineurin Activity and Uses in Predicting Therapeutic Outcomes  
The methods of the disclosure provide fluorescence-based assays for calcineurin activity, especially in isolated T cells. The methods include the stimulation of the T cells with agents that...
US20100158890 USE OF THROMBIN MUTANTS TO INHIBIT THE ANTICOAGULATION EFFECT OF THROMBIN INHIBITORS  
The present invention provides methods for inhibiting the anticoagulation effect of a thrombin inhibitor in a patient in need thereof comprising administration of a therapeutically effective...
7741117 Bone mineralization protein expression systems, and methods of studying intracellular signaling pathways induced thereby  
The present invention is directed to methods of switching a differentiation of a cell from a non-osteogenic lineage into an osteogenic lineage. The present invention is also directed to methods of...
US20100151492 METHODS FOR THE TREATMENT OF INFECTIONS AND TUMORS  
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced...
US20100144545 Arrays, Systems, and Methods of Using Genetic Predictors of Polycystic Diseases  
Embodiments of the present disclosure encompass resequencing and comparative genomic hybridization arrays for identifying inherited polycystic diseases. The arrays allow identification of one or...
US20100137788 METHODS AND SYSTEMS FOR DETERMINING AN INTRAVENOUS INSULIN INFUSION RATE TO CORRECT HYPERGLYCEMIA OF A PATIENT, TO MAINTAIN EUGLYCEMIA OF A PATIENT, AND TO PREVENT HYPOGLYCEMIA OF A PATIENT  
Methods and systems for determining an intravenous infusion rate to correct hyperglycemia of a patient, to maintain euglycemia of a patient, and to prevent hypoglycemia are disclosed. In one...
US20100136552 Methods and compositions for DMXL-associated mental retardation  
The present invention provides a method of identifying a human subject as having an increased likelihood of having DMXL-associated mental retardation, comprising detecting, in a nucleic acid...
US20100130381 NOVEL HIV-1 REVERSE TRANSCRIPTASE CODON DELETION AND ITS USE IN THE MANAGEMENT AND TREATMENT OF HIV INFECTIONS  
The present invention provides an isolated HIV-1 mutant and isolated nucleic acid molecules comprising HIV-RT coding sequences harboring a novel mutation in the S68 codon, and in particular,...
US20100119538 CHIMERIC OSTEOGENIC FACTOR CONTAINING PROTEINS CAPABLE OF INCREASED NUCLEAR LOCALIZATION AND METHODS OF USE THEREOF  
Compositions comprising osteogenic factors fused with membrane transduction domains of viral proteins are provided. Also provided are methods of expression and use of such compositions. Further,...
US20100119490 Therapeutic Use of CD31 Expressing Cells  
As described below, the present invention features compositions and methods related to the isolation, culture and therapeutic use of CD31-expressing cells.
7713708 Immunological assay system and method  
An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image...
7713544 Biological component comprising artificial membrane  
A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain...
US20100112561 FLUORESCENT NUCLEOSIDE ANALOGUES  
Briefly described, embodiments of the present disclosure include novel fluorescent nucleoside analogs (fNAs) including a fluorescent nucleobase, selected from a purine and a pyrimidine base or...
US20100105748 METHODS AND COMPOSITIONS FOR TREATMENT OF DRUG ADDICTION  
The present disclosure relates to methods of treating a stimulant addiction of a patient comprising administering to a patient in need a therapeutically effective dose of a selective dopamine...
US20100093986 METHODS OF DIRECT GENOMIC SELECTION USING HIGH DENSITY OLIGONUCLEOTIDE MICROARRAYS  
The present disclosure encompasses methods (hereinafter termed ‘Microarray-based Genomic Selection’ (MGS), capable of isolating user-defined unique genomic sequences from complex eukaryotic genomes.
US20100087907 Apparatus And Methods For Treating The Aorta  
An endovascular stent and an aortic valve replacement can be used to treat the aorta. An endovascular stent suitable for treating the ascending aorta includes a circumferential wall with one or...
US20100087738 SYSTEMS AND METHODS FOR QUANTIFYING CARDIAC DYSSYNCHRONY  
In one embodiment, a system and method for quantifying cardiac dyssynchrony relate to capturing images of the heart over time as it beats, generating heart function profiles for discrete portions...
7691814 Osteogenic compositions comprising an amino acid sequence capable of being phosphorylated by CAMK2  
Novel osteogenic compositions and methods are provided. In a broad aspect, the composition comprises either a first amino acid sequence which is capable of being phosphorylated by CAMK2; or a...
7691289 Compositions, materials incorporating the compositions, and methods of using the compositions, and methods of using the compositions and materials  
Compositions, materials incorporating the compositions, and methods of use thereof, are disclosed. In one embodiment, the composition includes a metal nitrate selected from d-block metal nitrates...
7686781 Catheter for modified perfusion  
A catheter adapted for use in passing fluids and medicines therethrough for use in the perfusion or reperfusion of blood or blood-fluid mixtures into the arteries, veins, tissues, conduits, or...
US20100055155 SOLID DEODORIZER FOR OSTOMY POUCHES  
A solid deodorizer (14) for use on the inside surface (12) of an ostomy pouch (10). The solid deodorizer include a deodorizing mixture (24) and a carrier (16) by which the deodorizer is attached...
US20100048480 PRODUCTION OF ANTI-MICROBIAL PEPTIDES  
The present application provides methods of producing antimicrobial peptides (AMPs) in a cell, for example by expression a fusion protein that includes small ubiquitin related modifier (SUMO) and...
US20100048473 Modified Protein Polymers  
In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the...
US20100047277 VIROSOMES, METHODS OF PREPARATION, AND IMMUNOGENIC COMPOSITIONS  
Briefly described, virosomes, methods of preparing virosomes, immunogenic compositions that include virosomes, and methods of eliciting an immune response using immunogenic compositions that...
7662938 2′-fluoronucleosides  
A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors...
US20100035945 SMALL MOLECULE INHIBITORS OF BACTERIAL DAM DNA METHYLTRANSFERASES  
Disclosed are compounds, crystal structures, data representations, methods of using, and methods of identifying compounds in relation to DNA methylation and inhibition of methylation. In...
7655594 Materials for degrading contaminants  
Briefly described, compositions, materials including the compositions, methods of using the compositions, and methods of degrading contaminants, are described herein. The composition can include a...
7652033 HIF-1 inhibitors  
HIF-1 inhibitors and methods of their use are provided. In particular, 2,2-dimethylbenzopyran based compounds and methods of their use, for example in the treatment or prevention of...
7648993 Methods of treating disorders with Group I mGluR antagonists  
mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be...
7648845 Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
US20090325920 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20090325881 MODIFIED FACTOR VIII  
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
7638502 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...