Patents and Patent Applications from Emory University


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US20100087738 SYSTEMS AND METHODS FOR QUANTIFYING CARDIAC DYSSYNCHRONY  
In one embodiment, a system and method for quantifying cardiac dyssynchrony relate to capturing images of the heart over time as it beats, generating heart function profiles for discrete portions...
7691814 Osteogenic compositions comprising an amino acid sequence capable of being phosphorylated by CAMK2  
Novel osteogenic compositions and methods are provided. In a broad aspect, the composition comprises either a first amino acid sequence which is capable of being phosphorylated by CAMK2; or a...
7691289 Compositions, materials incorporating the compositions, and methods of using the compositions, and methods of using the compositions and materials  
Compositions, materials incorporating the compositions, and methods of use thereof, are disclosed. In one embodiment, the composition includes a metal nitrate selected from d-block metal nitrates...
7686781 Catheter for modified perfusion  
A catheter adapted for use in passing fluids and medicines therethrough for use in the perfusion or reperfusion of blood or blood-fluid mixtures into the arteries, veins, tissues, conduits, or...
US20100055155 SOLID DEODORIZER FOR OSTOMY POUCHES  
A solid deodorizer (14) for use on the inside surface (12) of an ostomy pouch (10). The solid deodorizer include a deodorizing mixture (24) and a carrier (16) by which the deodorizer is attached...
US20100048480 PRODUCTION OF ANTI-MICROBIAL PEPTIDES  
The present application provides methods of producing antimicrobial peptides (AMPs) in a cell, for example by expression a fusion protein that includes small ubiquitin related modifier (SUMO) and...
US20100048473 Modified Protein Polymers  
In an embodiment, a number of synthetic protein triblock copolymers are provided comprising first and second end hydrophobic blocks separated by a central hydrophilic block. In particular, the...
US20100047277 VIROSOMES, METHODS OF PREPARATION, AND IMMUNOGENIC COMPOSITIONS  
Briefly described, virosomes, methods of preparing virosomes, immunogenic compositions that include virosomes, and methods of eliciting an immune response using immunogenic compositions that...
7662938 2′-fluoronucleosides  
A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors...
US20100035945 SMALL MOLECULE INHIBITORS OF BACTERIAL DAM DNA METHYLTRANSFERASES  
Disclosed are compounds, crystal structures, data representations, methods of using, and methods of identifying compounds in relation to DNA methylation and inhibition of methylation. In...
7655594 Materials for degrading contaminants  
Briefly described, compositions, materials including the compositions, methods of using the compositions, and methods of degrading contaminants, are described herein. The composition can include a...
7652033 HIF-1 inhibitors  
HIF-1 inhibitors and methods of their use are provided. In particular, 2,2-dimethylbenzopyran based compounds and methods of their use, for example in the treatment or prevention of...
7648993 Methods of treating disorders with Group I mGluR antagonists  
mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be...
7648845 Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
US20090325920 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20090325881 MODIFIED FACTOR VIII  
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
7638502 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
7635690 HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine  
The present invention discloses a method for treating HIV that includes administering β-D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or...
US20090311194 METHODS AND COMPOSITIONS FOR THE PRODUCTION AND USE OF MAGNETOSOMES  
Methods and compositions for using magnetosomes as cellular contrast agents and markers for magnetic resonance imaging are provided. Certain methods involve synthesizing magnetosomes in a cell as...
US20090306035 Compounds and Methods for modulating the Silencing of a Polynucleotide of Interest  
Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an...
US20090296998 Assessing Tumor Response to Therapy  
Systems, methods and computer program products identify first biologic data in a region of interest in a first image and calculate a first biologic volume histogram from the first biologic data....
US20090279736 MAGNETIC RESONANCE EYE TRACKING SYSTEMS AND METHODS  
Embodiments of magnetic resonance eye tracking systems and methods are disclosed. One embodiment, among others, comprises a method that receives magnetic resonance based data and determines...
7615542 Dioxolane thymine and combinations for use against 3TC/AZT resistant strains of HIV  
The present invention relates to the use of a dioxolane thymine compound according to the chemical structure of Formula (I): where R1 is H, an acyl group, a C1-C20 alkyl or ether group, a...
US20090276187 Evaluating Magnetic Resonance Spectra  
Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various...
US20090270329 METHODS OF ADMINISTERING PORCINE B-DOMAINLESS FVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20090259099 IMAGE-BASED CONTROL SYSTEMS  
Image-based control systems and methods automate the adjustment of medical devices. An image based-control system for an endoscope can include, in addition to the endoscope, a processing system...
US20090253710 NMDA Receptor Antagonists for Neuroprotection  
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain...
US20090240041 TUMOR IMAGING COMPOUNDS  
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB)...
US20090239887 Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
US20090234573 Travel Partner Matching Using Selectable Map Interface  
Systems and methods for travel partner matching using a map-based user selectable interface. A user can search for potential travel partner matches using a map-based user selectable interface. In...
US20090234100 OSTEOGENIC COMPOSITIONS COMPRISING AN AMIONO ACID SEQUENCE WHICH IS CAPABLE OF BEING PHOSPHORYLATED BY CAMK2  
Novel osteogenic compositions and methods are provided. In a broad aspect, the composition comprises either a first amino acid sequence which is capable of being phosphorylated by CAMK2; or a...
7588827 Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof  
Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among...
US20090221544 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY VIA A TAPERED ADMINISTRATION PROTOCOL  
The present invention provides methods for the treatment or the prevention of neuronal damage in the CNS. Specifically, the methods of the invention provide for the administration of a...
US20090217402 METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF PEPTIDASES IN MACROPHAGE AND MACROPHAGE-LIKE CELLS  
Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects,...
US20090208533 NEISSERIA MENINGITIDIS SEROGROUP A CAPSULAR POLYSACCHARIDE ACETYLTRANSFERASE, METHODS AND COMPOSITIONS  
Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the...
7576181 Method of administering porcine B-domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20090196831 NANOSTRUCTURES, METHODS OF SYNTHESIZING THEREOF, AND METHODS OF USE THEREOF  
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an...
US20090186361 METHODS OF PREDICTING THE PHARMACEUTICAL TOXICITY OF TAXANES  
The present disclosure relates to methods of identifying a recipient subject who has an elevated risk of an adverse or toxic reaction to a taxane. The predictive methods of the present disclosure...
7563775 Insulin-responsive DNA binding protein-1 and methods to regulate insulin-responsive genes  
The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 (IRDBP-1) and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that...
US20090181397 PREDICTIVE AND DIAGNOSTIC METHODS FOR CANCER  
The present disclosure encompasses methods of diagnosing the presence of a cancer, and particularly a cancer of prostate or breast tissue, in a human subject, predicting the outcome or severity of...
7560107 Modified factor VIII  
Modified porcine factor VIII is disclosed in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful for treatment of...
US20090176745 TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
7557139 Triptolide analogs for the treatment of autoimmune and inflammatory disorders  
The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of...
US20090169861 POROUS MATERIALS EMBEDDED WITH NANOSPECIES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
7550299 Method for predicting onset/risk of atrial fibrillation (AF)  
A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a...
US20090149416 2' and 3'-Substituted Cyclobutyl Nucleoside Analogs for the Treatment Viral Infections and Abnormal Cellular Proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
7544715 Tumor imaging compounds  
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB)...
7537902 Methods and kits using a molecular interaction between a Smurf-1 WW domain and LIM mineralization protein isoforms  
The instant application provides kits and methods for identifying agents which induce or inhibit the osteogenic effect of LMP or BMP proteins. The kits are directed to methods which measure either...
US20090130034 RE-ENGINEERED UV DAMAGE ENDONUCLEASE, COMPOSITIONS AND METHODS  
Provided are methods and compositions for reducing damage to skin by ultraviolet light and other agents that cause distortion to double stranded DNA and methods for reducing damage to other organs...
US20090123365 Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof  
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a...