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Patents and Patent Applications from Emory University


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US20050074430 Viruses targeted to hypoxic cells and tissues  
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
US20050069551 Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis  
Compositions and methods are provided for delivering cytotoxic compounds, such as natural curcumoids and synthetic curcumin analogs, specifically to cancer cells and to blood vessels that nourish...
US20050032244 Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
US20050032173 Fusion proteins with a membrane translocating sequence and methods of using same to inhibit an immune response  
An isolated fusion protein. In one embodiment of the present invention, the isolated fusion protein includes a membrane-translocating peptide sequence of about 8 to about 50 residues comprising at...
6852537 Transgenic circulating endothelial cells  
A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected...
6846672 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
US20050014181 Methods and compositions for the assessment of polymer assembly  
Systems and methods for identifying modulators of cell-mediated polymer assembly are provided. One aspect provides a high throughput method for identifying modulators of supramolecular polymer...
US20050013810 Regulating immune response using dendritic cells  
Disclosed within a method of altering immune responses using dendritic cells. One form of the method is a method of inducing immunological tolerance in an individual, where type 2 dendritic cells...
6843979 4-haloethenylphenyl tropane:serotonin transporter imaging agents  
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with...
6841363 Preparation of capped mRNA  
The invention provides a process for preparing capped mRNAs from an RNA mixture, e.g. whole RNA isolated from a cell or tissue extract, that includes combining in a reaction mixture RNA comprising...
US20050004148 Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane  
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of...
US20050003412 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
6838080 Induction of immunoglobulin class switching by inactivated viral vaccine  
The present disclosure provides methods and compositions for inducing an immune response to an antigen, especially in an immunogenic composition comprising sialic acid where the antigen comprises...
US20040259790 Methods for identifying and administering agents that bias the immune response via dendritic cells  
The invention provides a method of regulating a Th2 immune response which comprises contacting a cell with an amount of a molecule effective to modulate an ERK ½ pathway and/or a c-FOS pathway in ...
US20040255956 Post-conditioning for the reduction of ischemic-reperfusion injury in the heart and other organs  
The present invention provides a method of post-conditioning reperfusion of an organ or tissue injured by ischemia. Also provided is a method of treating a myocardial infarction in a subject to...
US20040249134 Factor viii c2 domain variants  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients after being treated with factor VIII. Modified factor VIII is disclosed in which the amino...
US20040243057 Catheter for modified perfusion  
A catheter adapted for use in passing fluids and medicines therethrough for use in the perfusion or reperfusion of blood or blood-fluid mixtures into the arteries, veins, tissues, conduits, or...
US20040242610 Therapeutic nucleosides  
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are...
6824995 Diagnostic for metastatic prostate cancer  
The present disclosure provides methods for the diagnosis of metastatic prostate cancer and/or the prediction of the metastatic ability of prostate cancer in prostate biopsy tissue. Metastatic...
US20040236729 Systems and methods for clustering objects from text documents and for identifying functional descriptors for each cluster  
Systems and methods for organizing and aiding the interpretation of large amounts of data are disclosed. One embodiment of the system, among others, includes receiving gene names, associating the...
US20040230086 Compositions, materials incorporating the compositions, and methods of using the compositions and materials  
Compositions, materials incorporating the compositions, and methods of use thereof, are disclosed. In one embodiment, the composition includes a metal nitrate selected from d-block metal nitrates...
6812233 Therapeutic nucleosides  
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are...
US20040185116 Polyoxometalate materials, metal-containing materials, and methods of use thereof  
The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that...
US20040185078 Methods for removing a contaminant by a polyoxometalate-modified fabric or a polyoxometalate-modified cellulosic fiber and fabrics thereof  
The invention relates to a method for removing a contaminant from a gas phase or a liquid phase by contacting an article composed of (1) a fabric or cellulosic fiber and (2) a polyoxometalate,...
US20040181098 Aromatic vinyl ether compounds  
Aromatic vinyl ether compounds represented by Formula (1) or by Formula (2) 1 wherein each R and R′ is a hydrogen atom or a group represented by Formula (3) 2 and wherein the remaining variables a...
US20040176384 Curcumin analogs with anti-tumor and anti-angiogenic properties  
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
US20040171545 Plastic and elastic protein copolymers  
Synthetic protein copolymers with plastic and elastic properties, and methods producing the copolymers, are provided. For example, a BAB triblock copolymer comprises a hydrophilic block and one or...
US20040171124 Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
US20040167140 [5-carboxamido or 5-fluoro]-[2',3'-unsaturated or 3'-modified]-pyrimidine nucleosides  
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
US20040166535 Method fo assessing antidepressant drug therapy via transport inhibition of monoamine neurotransmitters  
A method of measuring the individual response to antidepressant drug therapy on the transport inhibition of monoamine neurotransmitters involves in vitro monitoring of radiolabeled monoamine...
US20040165696 Systems and methods for global optimization of treatment planning for external beam radiation therapy  
Systems and methods for providing an optimal treatment plan for delivering a prescribed radiation dose to a predefined target volume within a patient using an external beam radiation delivery unit...
6777441 Triptolide analogs for the treatment of autoimmune and inflammatory disorders  
The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of...
US20040152973 Automated planning volume contouring algorithm for adjuvant brachytherapy treatment planning in sarcoma  
A mathematical contouring algorithm that automatically determines the planning volume of a sarcoma prior to designing a brachytherapy treatment plan. The algorithm, utilizing computational...
US20040152630 14-3-3 Binding molecules as sensitizers for anticancer therapies  
Methods are provided for enhancing the death of a neaplastic cell comprising the administration of a therapeutically effective concentration of a 14-3-3 antagonist and at least one antineoplastic...
6770744 Modified factor VIII  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients after being treated with factor VIII. Modified factor VIII is disclosed in which the amino...
US20040147731 Polynucleotides and polypeptides relating to the modulation of sirp alpha-cd47  
Polypeptides that can modulate SIRPα-CD47 functions and methods of use of the polypeptides are presented. In addition, polynucleotides that encode the polypeptides referred to above are presented. ...
US20040138502 Ph-dependent nmda receptor antagonists  
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events...
6759216 Glycosylated, low antigenicity low immunogenicity factor VIII  
The development of inhibitory antibodies to blood coagulation factor VIII (fVIII) results in a severe bleeding tendency. These antibodies arise in patients with hemophilia A (hereditary fVIII...
US20040127439 Introduction of the wld gene for prevention of axonal degeneration in neurological diseases  
Polypeptides that can protect axons from axon degeneration and methods of use of the polypeptides are presented. Polynucleotides that can protect axons from axon degeneration and methods of use of...
US20040127427 Ketoamide inhibitors in chronic nerve disease  
Compositions and methods for treating neural pathologies are provided. In particular, compositions and methods for treating neural pathologies including axonal degeneration are provided. The...
US20040120943 Antithrombotic thrombin variants  
The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of...
US20040116963 Needle-suture combinations and methods of use  
Needle-suture combinations are disclosed that include two surgical needles, each including an end having a suture-receiving aperture, and two sutures attached to the ends of each of the two...
US20040116677 Glycopolymers and free radical polymerization methods  
A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a...
US20040116385 Treating and preventing viral infections with porphyrin-based compounds  
Porphyrins containing one or more negatively-charged, amphiphilic nido-carborane substituents have antiviral or virucidal activity. The most active compounds tested to date are negatively charged,...
6750211 Diimino compounds for use as modulators of cell regulation  
Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The...
US20040110439 Native protein mimetic fibers, fiber networks and fabrics for medical use  
The present disclosure provides spun fibers of proteins useful for the fibers, fiber networks and nonwoven fabrics for medical use, with these materials characterized by good biocompatibility...
US20040105871 Compositions and methods for generating an immune response  
The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing...
US20040101825 Viruses targeted to hypoxic cells and tissues  
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
US20040096443 Treatment of neurodegenerative diseases and conditions using par1 antagonists  
The present invention features methods for treating and/or preventing neurodegenerative and/or neurotoxic diseases, conditions, and injuries, by inhibiting the activity of protease-activated...
US20040093628 Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates  
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The...