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Patents and Patent Applications from Emory University


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US20070260201 METHOD FOR DRUG DELIVERY TO OCULAR TISSUE USING MICRONEEDLE  
Methods and devices are provided for administering a drug to a patient's eye. The methods include (a) inserting a hollow microneedle into the sclera or corneal stroma without penetrating across...
7285414 Viruses targeted to hypoxic cells and tissues  
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
7282556 Polynucleotides and polypeptides relating to the modulation of SIRPα-CD47  
Polypeptides that can modulate SIRPα-CD47 functions and methods of use of the polypeptides are presented. In addition, polynucleotides that encode the polypeptides referred to above are presented....
US20070213312 Hif-1 Inhibitors and Methods of Use Thereof  
Methods of treating a cancer or tumor, chemopreventative methods of prophylactically treating cancers or tumors, pharmaceutical compositions, methods for the treatment or prevention of a...
US20070212723 Human sodium channel isoforms  
The present invention relates to novel isoforms in or near the 5′ untranslated region (upstream of the start codon) and the 3′ untranslated region (down stream of the start codon) which correlates...
US20070197462 Treatment of EBV and KHSV infection and associated abnormal cellular proliferation  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
US20070190576 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
US20070190572 Methods and kits using a molecular interaction between a Smurf-1 WW domain and LIM mineralization protein isoforms  
The instant application provides kits and methods for identifying agents which induce or inhibit the osteogenic effect of LMP or BMP proteins. The kits are directed to methods which measure either...
US20070190544 Methods of screening for resistance to microtuble-targeting drugs  
The invention relates to methods for determining resistance or responsivity to microtubule-targeting drug treatment in cancer patients. The methods comprise obtaining a tumor cell sample from a...
7255991 Template-drive processes for synthesizing polymers and components related to such processes  
Template-directed processes for synthesizing polymers are presented in which a sequence-specific polymer is generated from a corresponding sequence-specific template. The generated polymer has a...
US20070178523 Novel druggable regions in set domain proteins, and methods of using the same  
The present invention relates to novel druggable regions discovered in histone H3 lysine methyltransferase DIM-5, which is a SET domain protein. The present invention further relates to methods of...
7247709 Mitogenic oxygenases  
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention...
US20070169210 Methods and compositions for modulating gamete adhesion  
Methods and compositions for modulating mammalian gamete adhesion are provided. Representative modulators of gamete adhesion include, but are not limited to polypeptides comprising at least one...
7244830 Glycopolymers and free radical polymerization methods  
A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a...
7244590 Regulatory protein for Nox enzymes  
The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell...
US20070160645 PostConditioning System And Method For The Reduction Of Ischemic-Reperfusion Injury In The Heart And Other Organs  
A postconditioning method and system for preventing injury to an organ or tissue in a subject during or after reperfusion following an ischemic event to the organ or tissue. The system can...
US20070157931 System and method for optimized delivery of an aerosol to the respiratory tract  
The present disclosure relates to systems, methods, and devices for controlling delivery of aerosolized formulations to patients in need of treatment, which optimizes aerosol deposition to the...
US20070148701 Immunological Assay System and Method  
An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image...
US20070148258 Dialysates and methods and systems related thereto  
Compositions, systems, and methods of treating conditions such as vascular calcification conditions are disclosed. A representative method includes administering to an individual in need of...
US20070141725 Immunological Assay System and Method  
An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image...
US20070139264 Method and arrangements relating to satellite-based positioning  
A method, an apparatus and a computer program for determining a location at which satellite ranging signals (RS1-RS 4) have been received. At least one pseudorange selection cycle (511, 512),...
US20070135342 Modified Factor VIII  
Modified porcine factor VIII is disclosed in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful for treatment of...
7226769 Dual oxidases as mitogenic and endocrine regulators  
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates and in peroxidative reactions that affect...
7223583 Antithrombotic thrombin variants  
The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of...
US20070116689 LIM mineralization protein splice variants  
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
7211570 Treatment of EBV and KHSV infection  
A method and composition for the treatment, prevention and/or prophylaxis of a host, and in particular, a human, infected with Epstein-Barr virus (EBV), is provided that includes administering an...
US20070082879 Imaging Agents  
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
7202053 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
7202052 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
US20070078142 Treatment of tuberous sclerosis associated neoplasms  
The present invention relates to the use of PDGF receptor tyrosine kinase or bcr-abl tyrosine kinase inhibitors, especially of N-phenyl-2-pyrimidine-amine derivatives of formula I, in which the...
US20070078117 Methods for the treatment of a traumatic central nervous system injury  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
7189357 Immunological assay system and method  
An immunological or immunohematological assay system is disclosed that includes a filter vessel capable of containing an assay sample, an incubator, a sample separation system, an image...
US20070054930 CXCR4 antagonists for the treatment of medical disorders  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
US20070027406 Display enhanced testing for concussions and mild traumatic brain injury  
Cognitive assessment systems and methods that provide an integrated solution for evaluating the presence or absence of cognitive impairment. The present invention is used to test cognitive...
US20070025964 HIV-1 mutations selected for by beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine  
The present invention discloses a method for treating HIV that includes administering β-D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or...
7160999 Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
US20060292073 Stereoselective Synthesis of Amino Acid Analogs for Tumor Imaging  
The radiolabeled non-natural amino acid 1-amino-3-cyclobutane-1-carboxylic acid (ACBC) and its analogs are candidate tumor imaging agents useful for positron emission tomography and single photon...
7148027 Method of assessing antidepressant drug therapy via transport inhibition of monoamine neurotransmitters  
A method of measuring the individual response to antidepressant drug therapy on the transport inhibition of monoamine neurotransmitters involves in vitro monitoring of radiolabeled monoamine...
7142910 Methods of indirectly stimulating the vagus nerve with an electrical field  
Controlled cessation of heart beat during coronary bypass surgery and other cardiac surgeries on a beating heart improves surgical technique, and is achieved typically by electrical stimulation of...
US20060264451 CXCR4 antagonists for the treatment of HIV infection  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry...
US20060253127 Endoluminal linear suturing device  
A device for suturing tissue of a patient includes a tube defining a bore extending longitudinally within the tube and at least one suction opening in the exterior surface. A path is arranged...
7122634 Modified factor VIII  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor...
US20060229327 Therapeutic nucleosides  
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are...
US20060229239 Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis  
The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. The present invention...
7119249 Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates  
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The...
US20060223835 2' and 3'- substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
7115584 HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine  
The present invention discloses a method for treating HIV that includes administering β-D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or...
US20060216702 Virus-like particles, methods of preparation, and immunogenic compositions  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using...
US20060210979 Methods of detecting gene expression in normal and cancerous cells  
The present invention provides methods for detecting gene expression in normal and cancerous cells. Specifically, provided are methods utilizing molecular beacons (MB) technology combined with...
US20060205671 Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury  
Methods and compositions including combined use of a serine protease inhibitor and adenosine when administered as a single pharmaceutical composition, concomitantly or sequentially in any order to...