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Patents and Patent Applications from Emory University


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US20060013805 Transgenic circulating endothelial cells  
A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected...
US20060002903 Anti-inflammatory conformal barriers for cell transplantation  
The invention comprises anti-inflammatory conformal barriers with controllable permeability properties that can be applied to living cells prior to transplant, and methods for coating living cells...
US20050277762 Semisynthetic protein-based site-directed probes for identification and inhibition of active sites, and methods therefor  
A C-terminally modified Ubiquitin (Ub) derivative) ubiquitin vinyl sulfone (UbVS), which is specific for deubiquitinating enzymes (DUBs), was synthesized as an active site directed probe that...
US20050265922 Multimodality nanostructures, methods of fabrication thereof, and methods of use thereof  
Briefly described, embodiments of this disclosure include multimodality nanostructures, methods of forming the multimodality nanostructures, and methods of using the multimodality nanostructures.
US20050244399 Materials and method for promotion of nerve regeneration  
The subject invention pertains to the therapeutic use of certain GAG-degrading enzymes, and enzyme combinations, to promote nerve repair and regeneration.
6953666 Biomarkers for oxidative stress  
This invention related generally to methods of detecting and quantifying biomarkers of oxidative stress in proteins. The biomarker may be any amino acid that has undergone oxidation (or other...
US20050215527 Antiviral activity and resolution of 2-hydroxymethyl-5- (5-fluorocytosin-1-yl)-1, 3-oxathiolane  
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of...
6949522 β-2′- or 3′-halonucleosides  
The present invention includes compounds and compositions of β-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or ...
6949521 Therapeutic azide compounds  
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...
6939965 Process of manufacture of 1,3-oxathiolane nucleosides using titanium trichloride mono-isopropoxide  
Processes for the preparation of 1,3-oxathiolane nucleosides are provided that include reacting a 5-O-protected-oxymethyl-1,3-oxathiolane with a silylated nucleoside in the presence of...
US20050192458 Tumor imaging compounds  
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB) ...
6936298 Antithrombogenic membrane mimetic compositions and methods  
The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other...
US20050187188 Methods for the treatment of a traumatic central nervous system injury  
The present invention provides methods for conferring a neuroprotective effect on a population of cells in a subject following a traumatic injury to the central nervous system. Specifically, the...
US20050180945 Multivalent polymers with chan-terminating binding groups  
Polymeric molecules including glycopolymers useful for biomolecular recognition processes are provided comprising anchoring groups by which they can be immobilized onto surfaces. These molecules...
US20050171067 Methods of treating disorders with group I mGluR antagonists  
mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be...
US20050164361 Self-assembling-peptide-based structures and processes for controlling the self-assembly of such structures  
The thermodynamics of self-assembling peptides may be altered to produce different morphologies. By altering environmental factors, initiation and propagation of self-assembly processes may be...
US20050159307 Materials for degrading contaminants  
Briefly described, compositions, materials including the compositions, methods of using the compositions, and methods ods of degrading contaminants, are described herein. The composition can...
6916821 Methods of treating disorders with Group I mGluR antagonists  
mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be...
US20050148599 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states  
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit...
6911424 2′-fluoronucleosides  
A class of 2′-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including t...
6911306 TMS1 compositions and methods of use  
The invention relates to the identification of a novel gene, TMS1, which is transcriptionally silenced as a result of methylation. Nucleic acids and polypeptides are provided as are methods and...
US20050136258 Bioconjugated nanostructures, methods of fabrication thereof, and methods of use thereof  
Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the...
US20050130167 Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring  
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and...
US20050130151 Method and identification of downstream mrna ligands to fmrp and their role in fragile x syndrome and associated disorders  
Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for...
US20050123997 Modified fVIII having reduced immunogenicity through mutagenesis of A2 and C2 epitopes  
Specific amino acid loci of human fVIII interact with inhibitory antibodies of hemophilia patients after being treated with fVIII. Modified fVIII is disclosed in which the amino acid sequence is...
US20050123913 Human mitochondrial dna polymorphisms, haplogroups, associations with physiological conditions, and genotyping arrays  
This invention provides human mtDNA polymorphisms that are diagnostic of all the major human haplogroups and methods of diagnosing those haplogroups and selected subhaplogroups. This invention also...
US20050119243 HIF-1 inhibitors and methods of use thereof  
Methods of treating cancer or tumor, chemopreventative methods of prophylactically treating cancers or tumors, pharmaceutical compositions, methods for the treatment or prevention of a...
US20050118684 Nucleic acid and amino acid sequences encoding high-level expressor factor VIII polypeptides and methods of use  
Methods and compositions are provided that allow for high-level expression of a factor VIII polypeptide. More specifically, methods and compositions are provided comprising nucleic acid and amino...
US20050118562 Methods for minimizing spasticity in blood vessel grafts  
Methods for minimizing spasticity in blood vessels during transplantation, in both ex-vivo and in-vivo procedures are disclosed.
6900026 Methods for identifying compounds as antioxidants  
The present application describes methods for the testing of compounds of potential usefulness as therapeutic antioxidants and/or as therapeutic free radical scavengers. The animal model for...
6900008 Methods and formulations for minimizing spasticity in blood vessel grafts  
The present invention relates to me methods for minimizing spasticity in blood vessels during transplantation and more particularly for minimizing spasticity in arterial transplants, for both...
6898302 Systems, methods and computer program products for the display and visually driven definition of tomographic image planes in three-dimensional space  
Apparatuses, methods and computer program products for scan plane geometry definition in tomographic data acquisition via an interactive three-dimensional (3-D) graphical operator interface. The...
6896900 β-L-2'-deoxy-nucleosides for the treatment of HIV infection  
Compounds and pharmaceutical compositions active against HIV are provided, as is a method for the treatment of HIV infection in humans and other host animals is provided comprising administering an...
US20050106184 Neisseria mutants, lipooligosaccharides and immunogenic compositions  
Provided herein are mutant strains of Neisseria meningitidis which produce Kdo-free lipid A as well as the Kdo-free lipid A molecules and immunogenic compositions containing such Kdo-free lipid A...
6890931 Methods of treating disorders with group I mGluR antagonists  
Compositions and uses of mGluR5 antagonists for the treatment and prevention of neurological disorders, such as Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome, are disclosed.
US20050096698 Suture needles and methods of use  
A suture needle is disclosed that includes a shaft, the shaft being marked at least partially with a visual indicator; and a puncture tip at one end of the shaft. The shaft of the needle includes a...
US20050096396 Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning  
Methods for treating an individual with a psychiatric order with a pharmacologic agent that enhances learning or conditioning in combination with a session of psychotherapy are provided. These...
US20050091704 Ant2 conditional knockout mouse and methods  
Described are methods for inactivating adenine nucleotide transporter proteins in specific tissues of a transgenic nonhuman animal using a conditional knockin/knockout technology such as the...
US20050090428 Porphyrins with virucidal activity  
Compositions and methods of using thereof for the prevention of sexually transmitted diseases resulting from infection with one or more of viral pathogens have been developed. The compositions...
US20050089844 Novel dual oxidases as mitogenic and endocrine regulators  
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates and in peroxidative reactions that affect biological...
US20050079584 Modified factor VIII  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor...
US20050074430 Viruses targeted to hypoxic cells and tissues  
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
US20050069551 Cytotoxic compound-protein conjugates as suppressors of tumor growth and angiogenesis  
Compositions and methods are provided for delivering cytotoxic compounds, such as natural curcumoids and synthetic curcumin analogs, specifically to cancer cells and to blood vessels that nourish...
US20050032244 Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
US20050032173 Fusion proteins with a membrane translocating sequence and methods of using same to inhibit an immune response  
An isolated fusion protein. In one embodiment of the present invention, the isolated fusion protein includes a membrane-translocating peptide sequence of about 8 to about 50 residues comprising at...
6852537 Transgenic circulating endothelial cells  
A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected...
6846672 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
US20050014181 Methods and compositions for the assessment of polymer assembly  
Systems and methods for identifying modulators of cell-mediated polymer assembly are provided. One aspect provides a high throughput method for identifying modulators of supramolecular polymer...
US20050013810 Regulating immune response using dendritic cells  
Disclosed within a method of altering immune responses using dendritic cells. One form of the method is a method of inducing immunological tolerance in an individual, where type 2 dendritic cells...
6843979 4-haloethenylphenyl tropane:serotonin transporter imaging agents  
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes and 4-haloethenylphenyl tropane families are described as diagnostic and therapeutic agents for diseases associated with...