Patents and Patent Applications from Emory University


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US20090011991 Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis  
The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. Conjugates for...
7473687 Methods for the treatment of a traumatic central nervous system injury  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20080318914 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
7468436 Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
7468357 Nucleosides with anti-hepatitis B virus activity  
A method for the treatment of a host, and in particular, a human, infected with hepatitis B virus (HBV) is provided that includes administering an effective amount of a β-L-nucleotide, optionally...
US20080312279 Compositions for Treating Fragile X and Other Disorders Methods of Use Thereof, and Screening for Compounds for Fragile X and Other Disorders  
Methods of screening compounds, active compositions, pharmaceutical compositions, methods of treating disorders, methods of preventing disorders, and kits to screen a library of compounds, are...
US20080306326 Drive Circuit For Magnetic Stimulation  
The inventive technique includes devices and methods for generating a magnetic field. One such device may include an inductor for generating a magnetic field and a power source for providing...
US20080300298 Honokiol Derivates For the Treatment of Proliferative Disorders  
The present invention provides novel honokiol derivatives, as well as pharmaceutical compositions containing the honokiol derivatives. These compounds and pharmaceutical compositions can be used...
7459145 Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring  
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and...
US20080292599 Chondrogenic Compositions and Methods of Use  
The invention provides a method of treatment joint and disk disease comprising administering to the subject in need thereof a novel composition comprising a substantially purified plurality of...
7452530 Reversal of viral-induced systemic shock and respiratory distress by blockade of the lymphotoxin beta pathway  
This invention provides methods of inducing an antiviral response in an individual comprising administering to the individual an effective amount of a LT-B blocking agent and a pharmaceutically...
US20080280846 2', 3'-DIDEOXYNUCLEOSIDE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRIDAE INFECTIONS  
A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an...
US20080280294 Inherited Mitochondrial Dna Mutations in Cancer  
A method is provided for identifying a subject likely to have, or at risk of developing a disease condition correlated with increased reactive oxygen species (ROS), including cancer, by...
7450063 Method and arrangements relating to satellite-based positioning  
Alleviating ambiguous pseudorange reconstruction in connection with satellite-based positioning of mobile terminals with assistance data such as Assisted GPS (AGPS). An initial pseudorange...
US20080275016 FULVENE AND FULVALENE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are fulvene and/or fulvalene analogs. The compounds and...
US20080268445 Ant2 Conditional Knockout Mouse and Methods  
Described are methods for inactivating adenine nucleotide transporter proteins in specific tissues of a transgenic nonhuman animal using a conditional knockin/knockout technology such as the...
US20080268013 Polyethylene Oxide Polymers Including Anti-Inflammatory Glycodendrons  
Poly(ethylene oxide) (PEO) glycodendrimers can serve as multivalent inhibitors of selectin-mediated leukocyte recruitment regulating inflammatory response. Disclosed are compounds and methods...
7439351 2′ or 3′ -deoxy and 2′, 3′-dideoxy-β-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti-viral agents  
Method for the sterospecific preparation of 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentafuranonucleoside compounds. 2′ or 3′ deoxy and 2′,3′-dideoxy-β-L-pentofuranonucleoside compounds are also...
7439221 Methods and compositions for modulating gamete adhesion  
Methods and compositions for modulating mammalian gamete adhesion are provided. Representative modulators of gamete adhesion include, but are not limited to polypeptides comprising at least one...
US20080254001 Novel bone mineralization protein expression systems, and methods of studying their intracellular signaling pathways  
The present invention is directed to methods of switching a differentiation of a cell from a non-osteogenic lineage into an osteogenic lineage. The present invention is also directed to methods of...
7432303 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states  
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit...
7432052 Method and identification of downstream mRNA ligands to FMRP and their role in fragile X syndrome and associated disorders  
Compositions and methods for identifying and/or modulating RNA transcripts and/or genes involved in fragile X syndrome and other associated disorders are provided. In particular, RNA targets for...
US20080241807 Apparatuses and Methods for Simulating Microlaryngeal Surgery  
Apparatus for simulating microlaryngeal surgery. In one embodiment, the apparatus includes a larynx model that emulates an actual larynx, the larynx model including an inner passage that includes...
7429560 Ketoamide inhibitors in chronic nerve disease  
Compositions and methods for treating neural pathologies are provided. In particular, compositions and methods for treating neural pathologies including axonal degeneration are provided. The...
US20080234320 CURCUMIN ANALOGS WITH ANTI-TUMOR AND ANTI-ANGIOGENIC PROPERTIES  
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
US20080226622 Hif Inhibitors  
HIF-1 inhibitors and methods of use thereof are provided.
7425309 Immunological assay system and method  
An immunological or immunohematological assay system is disclosed that includes a vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition...
US20080219922 Alzheimer's Disease Imaging Agents  
This invention provides compounds and methods of imaging amyloid deposits using radiolabeled compounds. This invention also provides a method of inhibiting the aggregation of amyloid proteins to...
7419966 [5-carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides  
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
US20080187580 Therapeutic nucleosides  
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are...
US20080187522 ENHANCING A POPULATION OF INSULIN RELEASING CELLS USING GFR-A1 AGONISTS  
Provided herein are pharmaceutical and transplant compositions and methods related to the treatment and prevention of diabetes. More specifically, the compositions and methods are related to...
US20080176845 Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease  
The present invention relates to method for treating inflammatory bowel disease that includes administration of an effective amount of an antagonist of A2B adenosine receptors (ARs).
7402588 Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane  
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of...
US20080125498 TREATMENT OF NEURODEGENERATIVE DISEASES AND CONDITIONS USING PAR1 ANTAGONISTS  
The present invention features methods for treating and/or preventing neurodegenerative and/or neurotoxic diseases, conditions, and injuries, by inhibiting the activity of protease-activated...
7375136 pH-dependent NMDA receptor antagonists  
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic...
7371766 Curcumin analogs with anti-tumor and anti-angiogenic properties  
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
US20080108707 Antiangiogenic, antitumor, chemopreventative agents  
Pharmaceutical compositions and methods of treating conditions such as angiogenic-, neoplastic-, and cancer-related conditions and skin conditions are disclosed. The methods include administering...
US20080097385 Therapeutic Adjuncts to Enhance the Organ Protective Effects of Postconditioning  
Provided herein is a method of postconditioning reperfusion of an organ or tissue injured by ischemia in combination with the administration of one or more tissue protective agents that enhance...
US20080097383 Cardioplegia Catheter System  
A cardioplegia catheter system for delivery of a cardioplegia solution, comprising a cardioplegia catheter comprising an elongate tubular catheter body that defines a continuous central lumen and...
US20080092113 SYSTEM AND METHOD FOR CONFIGURING A PROGRAMMABLE ELECTRONIC DEVICE TO INCLUDE AN EXECUTION ENGINE  
An electronic device configuration that models a dynamical system can be produced by compiling program code written in a specialized modeling language into directed flow graph data, and then...
US20080089866 Novel bone mineralization protein expression systems, and methods of studying their intracellular signaling pathways  
The present invention is directed to methods of switching a differentiation of a cell from a non-osteogenic lineage into an osteogenic lineage. The present invention is also directed to methods of...
7358049 Gene chip technology for determining memory genes  
The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during...
US20080075666 Methods and compositions for treating diastolic dysfunction  
Methods and compositions for treating and screening drugs for conditions are provided.
7348161 Macrolide efflux genetic assembly  
Macrolide resistance associated with macrolide efflux (mef) in Streptococcus pneumoniae has been defined with respect to the genetic structure and dissemination of a novel mefE-containing...
US20080051562 Thrombomodulin Derivatives and Conjugates  
The transmembrane human protein thrombomodulin (TM), as a critical regulator of the protein C pathway, represents the major anticoagulant mechanism that is operative in both normal and injured...
7335635 14-3-3 binding molecules as sensitizers for anticancer therapies  
Methods are provided for enhancing the death of a neaplastic cell comprising the administration of a therapeutically effective concentration of a 14-3-3 antagonist and at least one antineoplastic...
US20080033258 method for predicting onset/risk of atrial fibrillation (AF)  
A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a...
US20080014149 Methods and Compositions for Imaging and Biomedical Applications  
The present invention is directed to detectable compositions and methods for making and using such compositions. Detectable compositions comprise detectable constructs comprising a detectable...
US20080003619 NOVEL PROTEINS WITH ENHANCED FUNCTIONALITY AND METHODS OF MAKING NOVEL PROTEINS USING CIRCULAR PERMUTATION  
The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the...
7312240 Conformationally constrained paclitaxel analogs and their use as anticancer and anti-Alzheimers agents  
Constrained paclitaxel derivatives include a bridge extending from the C-3′ phenyl to either the C4 or -3 positions. Many of the constrained paclitaxel derivatives provide activity comparable or...