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Patents and Patent Applications from Emory University


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US20040152973 Automated planning volume contouring algorithm for adjuvant brachytherapy treatment planning in sarcoma  
A mathematical contouring algorithm that automatically determines the planning volume of a sarcoma prior to designing a brachytherapy treatment plan. The algorithm, utilizing computational...
US20040152630 14-3-3 Binding molecules as sensitizers for anticancer therapies  
Methods are provided for enhancing the death of a neaplastic cell comprising the administration of a therapeutically effective concentration of a 14-3-3 antagonist and at least one antineoplastic...
6770744 Modified factor VIII  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients after being treated with factor VIII. Modified factor VIII is disclosed in which the amino...
US20040147731 Polynucleotides and polypeptides relating to the modulation of sirp alpha-cd47  
Polypeptides that can modulate SIRPα-CD47 functions and methods of use of the polypeptides are presented. In addition, polynucleotides that encode the polypeptides referred to above are presented. ...
US20040138502 Ph-dependent nmda receptor antagonists  
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events...
6759216 Glycosylated, low antigenicity low immunogenicity factor VIII  
The development of inhibitory antibodies to blood coagulation factor VIII (fVIII) results in a severe bleeding tendency. These antibodies arise in patients with hemophilia A (hereditary fVIII...
US20040127439 Introduction of the wld gene for prevention of axonal degeneration in neurological diseases  
Polypeptides that can protect axons from axon degeneration and methods of use of the polypeptides are presented. Polynucleotides that can protect axons from axon degeneration and methods of use of...
US20040127427 Ketoamide inhibitors in chronic nerve disease  
Compositions and methods for treating neural pathologies are provided. In particular, compositions and methods for treating neural pathologies including axonal degeneration are provided. The...
US20040120943 Antithrombotic thrombin variants  
The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of...
US20040116963 Needle-suture combinations and methods of use  
Needle-suture combinations are disclosed that include two surgical needles, each including an end having a suture-receiving aperture, and two sutures attached to the ends of each of the two...
US20040116677 Glycopolymers and free radical polymerization methods  
A glycopolymer composition is provided comprising glycopolymer molecules having a polymer backbone; a first pendent unit comprising a linking group connected to said polymer backbone and a...
US20040116385 Treating and preventing viral infections with porphyrin-based compounds  
Porphyrins containing one or more negatively-charged, amphiphilic nido-carborane substituents have antiviral or virucidal activity. The most active compounds tested to date are negatively charged,...
6750211 Diimino compounds for use as modulators of cell regulation  
Compositions, methods of use, isolation and biosynthesis of diimino-piperazine derivatives useful for the modification of sphingolipid metabolism and other biological functions are described. The...
US20040110439 Native protein mimetic fibers, fiber networks and fabrics for medical use  
The present disclosure provides spun fibers of proteins useful for the fibers, fiber networks and nonwoven fabrics for medical use, with these materials characterized by good biocompatibility...
US20040105871 Compositions and methods for generating an immune response  
The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing...
US20040101825 Viruses targeted to hypoxic cells and tissues  
The present invention relates to compositions comprising a novel recombinant virus which replicates selectively in cells or tissues that are hypoxic or have an activated HIF pathway. The novel...
US20040096443 Treatment of neurodegenerative diseases and conditions using par1 antagonists  
The present invention features methods for treating and/or preventing neurodegenerative and/or neurotoxic diseases, conditions, and injuries, by inhibiting the activity of protease-activated...
US20040093628 Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates  
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The...
US20040091466 Regulatory protein for nox enzymes  
The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell...
US20040087035 Methods and compositions for treating platelet-related disorders using MPL pathway inhibitory agents  
The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of...
US20040082552 HIV-1 mutations selected for by beta-2',3'-didehydro-2',3'-dideoxy-5-fluorocytidine  
The present invention discloses a method for treating HIV that includes administering μ-D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or ...
US20040077661 Treatment of tuberous sclerosis associated neoplasms  
The present invention relates to the use of PDGF receptor tyrosine kinase or bcr-abl tyrosine kinase inhibitors, especially of N-phenyl-2-pyrimidine-amine derivatives of formula I, 1 in which the...
6723349 Polyoxometalate materials, metal-containing materials, and methods of use thereof  
The invention relates to a polyoxometalate topical composition for removing a contaminant from an environment, comprising a topical carrier and at least one polyoxometalate, with the proviso that...
US20040073295 Antithrombogenic membrane mimetic compositions and methods  
The present Specification describes materials and methods which provide for improved performance of medical prostheses, including vascular graft material, artificial heart valves, and other...
US20040072777 Epididymal antimicrobial peptides  
The present invention provides novel antimicrobial peptides expressed in the primate epididyrnis (hereinafter, “EP2 peptides”) and the nucleic acids encoding therefore. EP2 peptides and the nuc...
6720184 Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination  
This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of...
US20040067978 Methods of treating disorders with Group I mGluR antagonists  
mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be...
US20040067877 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections  
A method for the treatment or prevention of Flaviviridae infections, in particular, hepatitis C virus infection, in a host, and in particular, a human, is provided that includes administering an...
US20040063200 Biological component comprising artificial membrane  
A biocompatible biological component is provided comprising a membrane-mimetic surface film covering a substrate. Suitable substrates include hydrated substrates, e.g. hydrogels which may contain...
6714823 Cardiac pacing lead and delivery system  
A pacing lead that is useful for transvenous pacing of the left ventricle, particularly in patients with congestive heart failure. The pacing lead includes a tapered body of reduced diameter at its...
6713621 Chimeric oligonucleotides for modulating gene expression  
Genes coding for vascular cell adhesion molecules, particularly VCAM-1, are modulated through interaction of oligonucleotides with transcriptional regulatory factors which bind to the genes....
6713076 Methods for removing a contaminant by a polyoxometalate-modified fabric or a polyoxometalate-modified cellulosic fiber and fabrics thereof  
The invention relates to a method for removing a contaminant from a gas phase or a liquid phase by contacting an article composed of (1) a fabric or cellulosic fiber and (2) a polyoxometalate,...
6706512 Antithrombotic thrombin variants  
The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of...
6703396 Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
6699952 Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof  
A modular cytomimetic biocompatible biomaterial, comprising a phospholipid or phospholipid derivative comprising various functional groups (e.g., lipid, peptide, sugar) having specific chemical...
6689361 SPE-4 antibody preparations  
This application discloses SPE-4 related peptides, peptide-carrier protein conjugates and fusion proteins, immunogenic compositions, antibodies and methods for characterizing the SPE-4 related...
6680303 3′,5-difluoro-2′,3′-didehydropyrimidine nucleosides and methods of treatment therewith  
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or...
US20040009149 Multimeric binding complexes  
The invention provides multimeric receptor-binding complexes, including chemokine tetramers, useful for recognizing and binding receptors bound to the surface of a wide variety of cells. The...
6673843 Curcumin and curcuminoid inhibition of angiogenesis  
Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin,...
6673814 Delivery systems and methods for noscapine and noscapine derivatives, useful as anticancer agents  
The present invention relates to methods useful for the treatment of neoplastic diseases, tumor cells, and the treatment of cancer delivering compounds of the formula The invention provides various...
US20030235866 Immunological assay system and method  
An immunological or immunohematological assay system is disclosed that includes a vessel capable of containing an assay sample, an incubator, a sample separation system, an image acquisition...
6664272 Curcumin analogs with anti-tumor and anti-angiogenic properties  
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
6656960 Methods of performing vagal-induced asystole  
A method for indirectly stimulating a vagus nerve of a patient includes the steps of positioning one or more electrodes in the vicinity of the vagus nerve and then actuating the electrode(s) to...
US20030221206 Methods for producing transgenic animals  
The present invention relates to methods for producing transgenic animals. Specifically, the methods of the present invention include production of a transgenic animal by transgenic...
US20030216640 Automated planning volume contouring algorithm for adjuvant brachytherapy treatment planning in sarcoma  
A mathematical contouring algorithm that automatically determines the planning volume of a sarcoma prior to designing a brachytherapy treatment plan. The algorithm, utilizing computational...
US20030216534 Modular cytomimetic biomaterials, transport studies, preparation and utilization thereof  
A modular cytomimetic biocompatible biomaterial, comprising a phospholipid or phospholipid derivative comprising various functional groups (e.g., lipid, peptide, sugar) having specific chemical...
US20030215853 Template-drive processes for synthesizing polymers and components related to such processes  
Template-directed processes for synthesizing polymers are presented in which a sequence-specific polymer is generated from a corresponding sequence-specific template. The generated polymer has a...
US20030215440 ANTITHROMBOTIC THROMBIN VARIANTS  
The present invention relates to novel antithrombotic variants of thrombin or fragments thereof that are capable of proteolytically activating protein C, but which are substantially free of...
6642245 Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane  
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of...
6632805 Methods for using water-stabilized organosilanes  
A method of dyeing and treating a substrate using a water-stabilized organosilane. A method of antimicrobially treating a food article. A method of antimicrobially coating a fluid container. A...