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Patents and Patent Applications from Emory University


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7122634 Modified factor VIII  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor...
US20060229327 Therapeutic nucleosides  
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are...
US20060229239 Novel curcuminoid-factor VIIa constructs as suppressors of tumor growth and angiogenesis  
The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. The present invention...
7119249 Methods and transgenic mouse model for identifying and modulating factors involved in the production of reactive oxygen intermediates  
The present invention provides a transgenic non-human animal, in particular a transgenic mouse encoding the NOX and Duox family of proteins, which generate reactive oxygen intermediates (ROI). The...
US20060223835 2' and 3'- substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
7115584 HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine  
The present invention discloses a method for treating HIV that includes administering β-D-D4FC or its pharmaceutically acceptable salt or prodrug to a human in need of therapy in combination or ...
US20060216702 Virus-like particles, methods of preparation, and immunogenic compositions  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of eliciting an immune response using...
US20060210979 Methods of detecting gene expression in normal and cancerous cells  
The present invention provides methods for detecting gene expression in normal and cancerous cells. Specifically, provided are methods utilizing molecular beacons (MB) technology combined with...
US20060205671 Compositions and methods for use of a protease inhibitor and adenosine for preventing organ ischemia and reperfusion injury  
Methods and compositions including combined use of a serine protease inhibitor and adenosine when administered as a single pharmaceutical composition, concomitantly or sequentially in any order to...
US20060205009 Methods of assessing endothelial dysfunction using acute transient responese following fat administration  
The present invention provides methods utilizing the fat-induced antibody response (FIAR) to assess endothelial function. Additional methods are provided that utilize FIAR for diagnosing and...
7107089 Automated planning volume contouring algorithm for adjuvant brachytherapy treatment planning in sarcoma  
A mathematical contouring algorithm that automatically determines the planning volume of a sarcoma prior to designing a brachytherapy treatment plan. The algorithm, utilizing computational...
US20060199864 Selection of pH-dependent compounds for in vivo therapy  
This invention is in the area of improved methods for the selection of pH dependent compounds to be used before, during or after a pH-lowering event as a means to minimize or prevent tissue damage.
7101840 Polymeric drug formulations  
A method of forming a polymeric drug formulation in which a water-soluble drug is blended with a water-insoluble tissue-compatible polymer that is miscible in the solid phase with the drug, and...
7097858 Polyoxometalate materials, metal-containing materials, and methods of use thereof  
Polyoxometalate topical compositions for removing contaminants from an environment and methods of use thereof are disclosed. An embodiment of the polyoxometalate topical composition includes a...
7090853 Noscapine derivatives as adjuvant compositions and methods of use thereof  
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
US20060160143 Mitogenic oxygenases  
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention...
US20060154864 Transcript factor and an Akt substrate related to transcriptional action of insulin and applications of same  
A transcription factor capable of activating multiple insulin-responsive genes. In one embodiment, the transcription factor includes an NH2-domain containing thirteen epidermal growth factor...
7072720 Devices and methods for vagus nerve stimulation  
The present invention relates to apparatus and methods for electrically inducing and pharmacologically maintaining cardiac asystole. The present invention combines electrostimulation of the vagus...
7060455 Broad specificity DNA damage endonuclease  
The present disclosure describes DNA damage endonucleases which exhibit broad specificity with respect to the types of structural aberrations in double stranded DNA. These enzymes recognize double...
7053100 Therapeutic nucleosides  
The use of a 1,3-oxathiolane nucleoside analogue and pharmaceutically acceptable derivatives thereof for the treatment of hepatitis B virus infections is disclosed. Pharmaceutical formulations are...
7048923 Antibodies to mitogenic oxygenases  
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention...
7046762 Systems and methods for global optimization of treatment planning for external beam radiation therapy  
Systems and methods for providing an optimal treatment plan for delivering a prescribed radiation dose to a predefined target volume within a patient using an external beam radiation delivery unit...
7045614 LIM mineralization protein splice variants  
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
7045351 Mitogenic oxygenases  
The present invention relates to new genes encoding for the production of novel proteins involved in generation of reactive oxygen intermediates that affect cell division. The present invention...
US20060099583 Compositions and methods for identifying antiviral agents  
Disclosed are compositions and methods that can be used to identify antiviral compounds. The methods can be carried out by exposing a cell that expresses a host factor to a candidate compound. If...
US20060099578 Mitochondrial biology expression arrays  
This invention provides a library of genes involved in mitochondrial biology, arrays containing probes for genes involved in mitochondrial biology, methods for making such arrays, and methods of...
7041634 Method of inhibiting immune system destruction of transplanted viable cells  
This invention provides a method of inhibiting viable cells transplanted into a subject from being destroyed by the subject's immune system which comprises: a) containing the viable cells, or...
7037729 Porous materials embedded with nanospecies, methods of fabrication thereof, and methods of use thereof  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
US20060089707 Vascular conduit device and system for implanting  
The present invention provides a vascular conduit device including a deformable flange and complementary securing ring in cooperation for securing the device within an aperture defined in a tissue...
US20060088909 Virus-like particles, methods of preparation, and immunogenic compositions  
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of liciting an immune response using...
7033791 Nucleic acid molecules encoding modified factor VIII proteins, expression products, and methods of making the same  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor...
7029673 Regulatory protein for Nox enzymes  
The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell...
US20060079573 Methods and compositions for preventing vasospasm  
Methods and compositions for preventing or reducing vascular smooth muscle contraction are provided. Exemplary compositions comprise an MLCK inhibitor, for example wortmannin, in an amount...
US20060073168 Neisseria meningitidis serogroup a capsular polysaccharide acetyltransferase, methods and compositions  
Provided are recombinant DNA molecules that do not occur in nature encoding an O-acetyltransferase, vectors that direct expression of an O-acetyltransferase, recombinant host cells which express an...
7022521 Methods and compositions for treating platelet-related disorders using MPL pathway inhibitory agents  
The invention relates to the treatment of subjects for the purpose inhibiting vaso-occlusive events, including thrombosis and embolism, by administering agents which reduce the number of...
7012132 Modified factor VIII  
Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor...
US20060051839 DNA expression vectors and methods of use  
The present invention relates to novel plasmid constructs useful for the delivery of DNA vaccines. The present invention provides novel plasmids having a transcription cassette capable of directing...
7005454 Polymeric drug formulations  
Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also...
7005256 Gene chip technology for determining memory genes  
The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during...
US20060040284 TMS1 compositions and methods of use  
The invention relates to the identification of a novel gene, TMS1, which is transcriptionally silenced as a result of methylation. Nucleic acids and polypeptides are provided as are methods and...
US20060035358 Regulatory protein for Nox enzymes  
The present invention relates to nucleotides encoding for the production of novel regulatory proteins for Nox enzymes involved in generation of reactive oxygen intermediates that affect cell...
US20060013805 Transgenic circulating endothelial cells  
A process is provided for expanding the population of endothelial cells obtained from peripheral blood which can be transformed with a vector comprising a DNA sequence encoding a preselected...
US20060002903 Anti-inflammatory conformal barriers for cell transplantation  
The invention comprises anti-inflammatory conformal barriers with controllable permeability properties that can be applied to living cells prior to transplant, and methods for coating living cells...
US20050277762 Semisynthetic protein-based site-directed probes for identification and inhibition of active sites, and methods therefor  
A C-terminally modified Ubiquitin (Ub) derivative) ubiquitin vinyl sulfone (UbVS), which is specific for deubiquitinating enzymes (DUBs), was synthesized as an active site directed probe that...
US20050265922 Multimodality nanostructures, methods of fabrication thereof, and methods of use thereof  
Briefly described, embodiments of this disclosure include multimodality nanostructures, methods of forming the multimodality nanostructures, and methods of using the multimodality nanostructures.
US20050244399 Materials and method for promotion of nerve regeneration  
The subject invention pertains to the therapeutic use of certain GAG-degrading enzymes, and enzyme combinations, to promote nerve repair and regeneration.
6953666 Biomarkers for oxidative stress  
This invention related generally to methods of detecting and quantifying biomarkers of oxidative stress in proteins. The biomarker may be any amino acid that has undergone oxidation (or other...
US20050215527 Antiviral activity and resolution of 2-hydroxymethyl-5- (5-fluorocytosin-1-yl)-1, 3-oxathiolane  
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of...
6949522 β-2′- or 3′-halonucleosides  
The present invention includes compounds and compositions of β-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or ...
6949521 Therapeutic azide compounds  
Pharmaceutical prodrug compositions are provided comprising azide derivatives of drugs which are capable of being converted to the drug in vivo. Azide derivatives of drugs having amine, ketone and...