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5635365 |
Noninvasive diagnosis for allograft rejection
The present invention provides a noninvasive method for diagnosing and/or predicting a rejection episode in a transplant patient, for example, in a heart transplant patient, by determining a rise...
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5622649 |
Multiple emulsions and methods of preparation
Water-in-oil and water-n-oil-in-water multiple emulsions and methods of preparation employing polyoxyethylene polyoxypropylene block copolymers added to the inner aqueous phase during preparation...
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5614826 |
Methods for prepulsing in nuclear magnetic resonance pulse sequencing
A composite spin lock prepulse method compensates for magnetic field inhomogeneities in objects or materials under study using nuclear magnetic resonance (NMR). The effective magnetic field seen by...
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5607472 |
Intraocular lens for restoring accommodation and allows adjustment of optical power
An accommodating lens is designed to be inserted into a substantially intact capsulary bag having a capsulorexis opening in its anterior wall. The lens has an accommodating portion adapted to be...
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5602245 |
One vessel stereoselective glycosylation of purines and pyrimidines
A process for the preparation of 2',3' dideoxynucleosides, 2'-deoxynucleosides, and 2',3'-dideoxy-2',3'-didehydronucleosides is provided that includes the synchronous addition of a stereoselecting...
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5599796 |
Treatment of urogenital cancer with boron neutron capture therapy
Methods and compositions for treating urogenital tumors, and particular, cancer of the prostate, bladder, and kidney, with BCNT, are disclosed. Any boron-containing compound that is sufficiently...
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5587514 |
Diastereoselective synthesis of hydroxyethylene dipeptide isosteres
A process for the synthesis of hydroxyethylene dipeptide isosteres from α-N,N-di(protected)-amino(alkyl or substituted alkyl)methyl ketones that can be efficiently carried out on an industrial ...
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5583209 |
Hybrid human/porcine factor VIII
A hybrid human/porcine coagulation factor VIII is produced by isolation and recombination of human and porcine factor VIII subunits, or by genetic engineering of the human and porcine factor VIII...
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5580775 |
High affinity, brain-specific nucleic acids encoding a L-proline transporter, and vectors, and host cells comprising the same
The anatomical distribution, nucleic acid sequence, pharmacological properties, and inferred structural features of a cDNA encoding a high affinity, Na+ -dependent rat brain L-proline transporter...
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5571823 |
Pharmacological treatment of ocular development
A method of controlling the abnormal postnatal growth of the eye of a maturing animal which comprises the ocular administration of therapeutically effective amounts of a dopamine antagonist.
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5571117 |
Method of endoscopic stapling and suturing and instrument therefor
An endoscopic surgical stapler and suture placing instrument is provided having a means adjacent the distal end for removably positioning a suture in front of and in registry with the staple...
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5554372 |
Methods and vaccines comprising surface-active copolymers
The present invention comprises adjuvants which, when admixed with an antigen and administered into a human or animal, will induce a more intense immune response to the antigen than when the...
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5552019 |
Oxidative delignification of wood or wood pulp by transition metal-substituted polyoxometalates
A method for delignifying wood pulp and fiber is disclosed. The method comprises the steps of obtaining a wood pulp and exposing the wood pulp to a polyoxometalate of the formula [Vl Mom Wn Nbo Tap...
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5550017 |
Anti-paramyxovirus screening method and vaccine
A method is provided for detecting whether a test composition can inhibit cell fusion mediated by paramyxovirus infection. A method is also provided for identifying an antiviral peptide capable of...
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5549789 |
Oxidation of lignin and polysaccharides mediated by polyoxometalate treatment of wood pulp
A method for oxidative degradation of lignin and polysaccharide fragments dissolved during polyoxometalate delignification or bleaching of wood pulp, wood fiber or pulp obtained from a non-woody...
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5539116 |
Method and compositions for the synthesis of BCH-189 and related compounds
The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic...
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5523092 |
Device for local drug delivery and methods for using the same
A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a...
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5518879 |
Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination
This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of...
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5494794 |
Detection of mitochondrial DNA mutations associated with Alzheimer's disease and Parkinson's disease
This invention provides a method of Alzheimer's disease and/or Parkinson's Disease. The method comprises detecting in a sample from a subject the presence of a mutation, for example, in nucleotide...
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5494660 |
Method for inhibiting microbial binding to surfaces
A new class of biologically-active copolymers is provided capable of affecting biological systems in many different ways. The biologically-active copolymers of the present invention also have a...
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5484885 |
Chemotactic, antibiotic and lipopolysaccharide-binding peptide fragments of CAP37
Disclosed is a homogeneously pure monocyte chemotactic protein, CAP37, and the entire coding sequences for unprocessed and mature human CAP37 protein. Further, the recombinant production, from...
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5466445 |
Methods for reducing salmonella in chickens
A new class of biologically-active copolymers is provided capable of effecting biological systems in many different ways. The biologically active copolymers of the present invention also have a...
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5462163 |
Holder for sharp medical instruments with individual angularly presented encasements
A self-contained medical procedure kit and stand having a tray and receptacles for medical instruments is provided in such a way as to safely and easily allow a health care worker to remove sterile...
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5459057 |
Method of modifying cellular differentiation and function and compositions therefor
A method and composition for enhancing biological response modifiers, such as promoting cellular differentiation, by using a Vitamin A or an analog thereof and sphingosine or an analog thereof.
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5458874 |
Method of increasing monocyte chemotaxis with CAP37 and monocyte chemotactic portions thereof
Disclosed is a homogeneously pure monocyte chemotactic protein, CAP37, and the entire coding sequences for unprocessed and mature human CAP37 protein. Further, the recombinant production, from...
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5447914 |
Antimicrobial peptides
Peptides which exhibit antimicrobial activity comparable to certain known antibiotics are provided. These peptides are related in sequence to amino acid sequences within Cathepsin G. A broad...
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5444063 |
Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
A method and composition for the treatment of humans infected with HBV that includes the administration of an HBV treatment amount of a β-dioxolanyl purine nucleoside of the formula: ##STR1## ...
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5443827 |
Fibrin-targeted inhibitors of thrombin
A chimeric molecule that contains a fibrin-binding portion of an antibody covalently linked to an inhibitor of thrombin, which molecule is administered to inhibit thrombus formation and growth.
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5432273 |
Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors
A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and that proceeds with high...
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5418162 |
Serotonin transporter CDNA
Isolated DNA encoding a serotonin transporter is disclosed. Also disclosed are vectors and host cells containing the aforesaid DNA, methods of using the same, purified protein by the same, and...
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5414078 |
Preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides from acyclic, achiral precursors
A process for the preparation of 3'-substituted-2',3'-dideoxynucleosides and 2'-deoxynucleosides is provided that utilizes inexpensive, non-carbohydrate, acyclic, achiral starting materials and...
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5399352 |
Device for local drug delivery and methods for using the same
A device for the local delivery of a substance into a natural tissue conduit in the mammalian body, having a first clement capable of contacting the lumen of the conduit and a second element which...
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5383928 |
Stent sheath for local drug delivery
This invention provides a sheath for encompassing at least a portion of a stent to locally deliver a drug to an arterial wall or lumen into which the stent has been inserted, comprising a polymer...
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5380747 |
Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of...
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5364771 |
Hybrid human/porcine factor VIII
A hybrid human/porcine coagulation factor VIII is produced by isolation and recombination of human and porcine factor VIII subunits, or by genetic engineering of the human and porcine factor VIII...
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5328930 |
Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin
Methods for the treatment of Microsporidia keratoconjunctivitis and Acanthamoeba keratitis are disclosed that include the topical administration of an effective amount of fumagillin or a derivative...
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5304554 |
4-[(alkyl or dialkyl)amino]quinolines and their method of preparation
Novel 4-[(alkyl or dialkyl)amino]quinolines are disclosed that are prepared by condensin BACKGROUND OF THE INVENTION The United States government has rights in this invention as a result of a grant...
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5296349 |
Molecular genetic test for myoclonic epilepsy
The present invention relates to a method and manufacture for detecting neuromuscular disease, particularly Myoclonic Epilepsy and Ragged Red Fiber disease, by ascertaining whether a transition...
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5284843 |
Pharmacological treatment of ocular development
A method of inhibiting the abnormal postnatal axial growth of the eye of a maturing animal during conditions ordinarily leading to said abnormal growth, which comprises (1) determining the...
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5281616 |
Porphyrin and phthalocyanine antiviral compositions
Compositions for the inhibition of replication of human immunodeficiency virus containing one or more "porphyrins" possessing antiviral activity. As used herein "porphyrins" includes porphyrins,...
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5276151 |
Method of synthesis of 1,3-dioxolane nucleosides
A synthesis of 1,3-dioxolane nucleosides that includes condensing a 2-0-protected-5-0-acylated-1,3-dioxolane with a purine or pyrimidine base in the presence of a titanium containing Lewis acid to...
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5250294 |
Improved perfusion medium for transplantation of organs
In accordance with the present invention, a composition and method is provided for perfusion of organs. The present invention includes perfusion of organs in situ and before transplantation. The...
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5250019 |
Apparatus for stereotactic radiosurgery
An apparatus for performing stereotactic radiosurgery using a stationary radiation source is comprised of a frame, a platform rotatably connected to the frame about a vertical rotational axis, a...
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5240702 |
Method of treating stroke
In accordance with the present invention, a method is provided for treating stroke. More particularly, the present invention relates to a method for treating stroke comprising injecting a...
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5240701 |
Method of performing angioplasty procedures
In accordance with the present invention, a method is provided for improving angioplasty procedures by reducing tissue damage during the procedure comprising infusing a non-emulsion, homogeneous...
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5234683 |
Method of stimulating the immune system
The present invention relates to biologically-active copolymers and to compounds that can be safely used to cause the thymus of an animal or human to increase in size, thereby replenishing the...
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5232837 |
Method of altering sphingolipid metabolism and detecting fumonisin ingestion and contamination
This invention provides a method of altering the metabolism of sphingolipids in a cell comprising contacting the cell with a fumonisin, or an analog thereof. The invention also provides a method of...
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5212084 |
Retrovirus and related method used for producing a model for evaluating the antiretroviral effects of drugs and vaccines
A retrovirus and related method used in producing a model for evaluating the antiretroviral effects of drugs and vaccines includes the steps of removing T-lymphotropic retrovirus from a first...
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5210085 |
Method for the synthesis, compositions and use of 2'-deoxy-5-fluoro-3'-thiacytidine and related compounds
The present invention relates to a method of preparing the antiviral compounds 2'-deoxy-5-fluoro-3'thiacytidine (FTC) and various prodrug analogues of FTC from inexpensive precursors with the...
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5204466 |
Method and compositions for the synthesis of BCH-189 and related compounds
The present invention relates to a method of preparing BCH-189 and various analogs of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic...
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