Patents and Patent Applications from Emory University


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US20120029932 DISPLAY OF PATIENT-SPECIFIC DATA  
Systems, methods, and computer-program products identify clinical data corresponding to a plurality of patients located within a common health care delivery unit, and apply one or more rules to at...
US20120028977 Subunit Selective NMDA Receptor Potentiators For The Treatment Of Neurological Conditions  
Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive...
US20120028816 METHODS AND SYSTEMS FOR SCREENING FOR AND DIAGNOSING DNA METHYLATION ASSOCIATED WITH AUTISM SPECTRUM DISORDERS  
Methods and systems for population screening and diagnostics are provided. In particular methods and systems for population screening of individuals for genetic disorders due to alterations in DNA...
US20120027666 POLYOXOMETALATE WATER OXIDATION CATALYSTS AND METHODS OF USE THEREOF  
Homogeneous water oxidation catalysts (WOCs) for the oxidation of water to produce hydrogen ions and oxygen, and methods of making and using thereof are described herein. In a preferred...
US20120022086 CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS  
Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of...
US20120022070 Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use  
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and...
8101718 Methods of administering porcine B-domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20120003688 COMPOSITIONS AND METHODS FOR USING NADH OXIDASES  
The present disclosure relates generally to bacterial NADH oxidases and, more particularly, to novel NADH oxidases obtained from Lactobacillus plantarum, and derivatives thereof that demonstrate...
US20110319416 Subunit Selective NMDA Receptor Antagonists For The Treatment Of Neurological Conditions  
Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive...
8080659 CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
US20110306579 METHODS OF NEUROPROTECTION USING NEUROPROTECTIVE STEROIDS AND A VITAMIN D  
Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective...
US20110305636 COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT  
Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein,...
8071795 HIF inhibitors  
HIF-1 inhibitors and methods of use thereof are provided.
US20110294844 9-AMINONOSCAPINE AND ITS USE IN TREATING CANCERS, INCLUDING DRUG-RESISTANT CANCERS  
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
8067537 Composition and method for treatment of stomatitis  
A composition and a method effective in preventing or treating stomatitis are presented. The composition contains glutathione or a pharmaceutically acceptable salt thereof and/or orotic acid or a...
8067424 Selective inhibitors for cyclin-dependent kinases  
This invention provides a class of compounds which are useful for specifically inhibiting cyclin-dependent kinases. This class of compounds finds use in treating diseases resulting from...
US20110288044 Modulation of sodium channels by nicotinamide adenine dinucleotide  
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the...
US20110286919 CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER  
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs),...
US20110282587 COMPUTER READABLE STORAGE MEDIUMS, METHODS AND SYSTEMS FOR NORMALIZING CHEMICAL PROFILES IN BIOLOGICAL OR MEDICAL SAMPLES DETECTED BY MASS SPECTROMETRY  
Described herein are computer-readable storage mediums, methods and systems useful for analyzing samples via mass spectrometry. Aspects described herein include methods for normalizing mass...
US20110282081 Methods of Preparing 1-Deoxy-Sphingoid Bases and Derivatives Thereof  
Novel methods of synthesizing 1-deoxy-sphingoid bases and derivatives are disclosed. The synthesis is achieved from commercially available and inexpensive starting materials. The process includes...
US20110281908 Aminoquinoline Derived Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use  
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors and methods for making these classes are provided herein. These compounds are useful in treating and preventing cancer...
D648876 Portion of a LED lamp  
US20110275839 COMPOUNDS, INTERMEDIATES, AND METHODS OF PREPARING THE SAME  
The present disclosure provides optionally substituted seven-membered ring isomers of naturally occurring carbohydrate compounds, methods of synthesizing these compounds, intermediate compounds,...
US20110274651 Noscapine and Noscapine Analogs and Their Use in treating Infectious Diseases by Tubulin Binding Inhibition  
Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are...
US20110263553 STEROID ANALOGUES FOR NEUROPROTECTION  
Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are...
US20110262398 CARDIAC TREATMENT USING ANTI-FIBROTIC AGENTS  
Disclosed herein are reagents and methods for detecting and treating age-related diastolic dysfunction in an animal or a human.
US20110262354 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
US20110260111 QUANTUM DOTS, METHODS OF MAKING QUANTUM DOTS, AND METHODS OF USING QUANTUM DOTS  
Embodiments of the present disclosure provide: methods of making a quantum dot, quantum dots, and the like.
8034579 Proteins with enhanced functionality and methods of making novel proteins using circular permutation  
The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the...
8032335 Evaluating magnetic resonance spectra  
Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various...
US20110235884 Atlas-Assisted Synthetic Computed Tomography Using Deformable Image Registration  
Disclosed are systems for and methods of creating a synthetic image by registering a reference or atlas image to a clinical image using both rigid and deformable image registration algorithms. In...
US20110230361 PROSTATE CANCER BIOMARKERS TO PREDICT RECURRENCE AND METASTATIC POTENTIAL  
Described herein are methods for predicting the recurrence, progression, and metastatic potential of a prostate cancer in a subject. For example, the method comprises detecting in a sample from a...
US20110224752 MICROELECTRODE STIMULATION FOR TREATMENT OF EPILEPSY OR OTHER NEUROLOGIC DISORDER  
Methods for treating a neurologic disorder by neurostimulation. The stimulation may be applied using electromagnetic energy. In certain embodiments, distributed electrical stimulation is applied...
US20110224181 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
8008312 CXCR4 antagonists for the treatment of HIV infection  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor, and in particular to inhibit viral entry...
US20110206699 Methods for the Treatment of Graft-Versus-Host Disease  
Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and...
8003324 Modulation of sodium channels by nicotinamide adenine dinucleotide  
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the...
US20110191866 METHODS OF MAKING MONOCLONAL ANTIBODIES USING FUSION-PEPTIDE EPITOPE ADOPTIVE TRANSFER (F-PEAT) TECHNOLOGY  
Disclosed are compositions and methods for related to monoclonal antibodies specific for single amino acid variation in an antigen.
US20110189236 Methods and Compositions for the Display of Polypeptides on the Pili of Gram-Positive Bacteria  
Provided herein are methods and compositions for the display of polypeptides of interest on the tip of pili of Gram-positive bacteria. According to the present invention, the polypeptide of...
US20110189102 COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF  
The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific...
7989649 Tumor imaging compounds  
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB)...
US20110165077 IN VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE ENHANCED RAMAN NANOPARTICLE TAGS  
Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the...
7972311 Cardioplegia catheter system  
A cardioplegia catheter system for delivery of a cardioplegia solution, comprising a cardioplegia catheter comprising an elongate tubular catheter body that defines a continuous central lumen and...
US20110160223 NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders  
Provided are pharmaceutical compositions and methods of treatment or prophylaxis of certain neuropsychiatric conditions, in particular mood disorders. The compounds are of the general Formula I-V...
US20110160188 PARAMYXOVIRUS FAMILY INHIBITORS AND METHODS OF USE THEREOF  
Embodiments of the present disclosure include methods for identifying a compound or compounds useful as therapeutic agents in the treatment of paramyxovirus infections, compounds for the treatment...
US20110152692 SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE  
According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light...
US20110144483 IMAGING AGENTS  
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
US20110144196 TREATING VARIOUS DISORDERS WITH 7,8-DIHYDROXYFLAVONE AND DERIVATIVES THEREOF  
Novel compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of...
US20110144096 TREATING VARIOUS DISORDERS USING TRKB AGONISTS  
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
7960589 Synthesis of sphingosines and their derivatives  
Embodiments of the present disclosure provide for methods of making sphingosines and derivatives thereof, and the like.