Patents and Patent Applications from Emory University


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US20130210785 PROGESTERONE ANALOGS AND USES RELATED THERETO  
This disclosure relates to progesterone derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation...
US20130210774 POTENT AND SELECTIVE INHIBITORS OF HEPATITIS C VIRUS  
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other animal hosts. The compounds are as...
8507673 Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds  
Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-α]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected...
8501694 Method of administering porcine B-domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20130190402 Methods Of Treating Autism With mGluR5 Antagonists  
mGluR5 antagonists are used for the treatment of autism. The human treated by the methods of the invention can also have fragile X syndrome, epilepsy and anxiety.
US20130182929 SYSTEMS, METHODS, AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR GENERATING AN IMAGE INTEGRATING FUNCTIONAL, PHYSIOLOGICAL AND ANATOMICAL IMAGES  
Systems, methods and computer-readable storage mediums relate to generating an image that includes functional, anatomical, and physiological images. The generated image may be an integrated image...
8486408 Methods for the treatment of graft-versus-host disease  
Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and...
US20130177222 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR GENERATING AN IMAGE SERIES  
Systems, methods, and computer-readable storage media relate to generate an image series that includes a patient image and a medical image. The patient image and the medical image may be...
D685387 Graphical user interface for a display screen or a portion thereof  
US20130164218 HYPOXIA INDUCIBLE FACTOR-1 PATHWAY INHIBITORS AND USES AS ANTICANCER AND IMAGING AGENTS  
This disclosure relates to Hypoxia Inducible Factor-1 pathway inhibitors and uses as anticancer and imaging agents. In certain embodiments, the disclosure contemplates compounds and pharmaceutical...
US20130158082 METHODS OF MANAGING BLOOD SUGAR LEVELS AND COMPOSITIONS RELATED THERETO  
The disclosure relates to methods of managing blood sugar levels and compositions related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing diabetes,...
US20130157988 SUBSTITUTED ANDROST-4-ENE DIONES  
The disclosure relates to novel C4 and C6 substituted androst-4-ene diones as well as andros-1,4-diene diones and derivatives thereof, their process of preparation, pharmaceutical compounds...
US20130150332 9-AMINONOSCAPINE AND ITS USE IN TREATING CANCERS, INCLUDING DRUG-RESISTANT CANCERS  
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
US20130149247 VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE-ENHANCED RAMAN NANOPARTICLE TAGS  
Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the...
US20130149214 MICROVASCULAR FLUIDIC DEVICES, SYSTEMS AND METHODS RELATED THERETO  
Microfluidic devices and processes are provided that relate to microvascular-sized systems configured to identify specific pathophysiological characteristics related to the interactions between,...
8455468 Methods for the treatment of a traumatic central nervous system injury  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20130137760 GAMBOGIC AMINE, A SELECTIVE TRKA AGONIST WITH NEUROPROTECTIVE ACTIVITY  
Small molecule agonists, partial agonists, and antagonists for the TrkA receptor are described. The compounds are gambogic amines, where the carboxylic acid group of gambogic acid (CO2H) has been...
US20130137634 COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO  
The disclosure relates to compounds and compositions for forming bone and methods related thereto. In one embodiment, the disclosure relates to a composition comprising a compound disclosed...
US20130131157 TREATING VARIOUS DISORDERS USING TRKB AGONISTS  
Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four...
US20130123618 Imaging Agents  
This invention provides amino acid derivatives useful in detecting and evaluating brain and body tumors, including (1S,2S) anti-2-[18F]FACPC and (1R,2R) anti-2-[18F]FACPC.
US20130123185 METHODS OF TREATING AND DIAGNOSING ACUTE CHEST SYNDROME  
In certain embodiments, the disclosure relates to methods of treating or preventing organ inflammation or failure such as pulmonary inflammation comprising administering a heme scavenger such as...
US20130122514 METHODS FOR DETERMINATION OF PROTEIN PHOSPHATASE ACTIVITY, AND USES IN PREDICTING THERAPEUTIC OUTCOMES  
One aspect of the present disclosure encompasses methods for determining a protein kinase or phosphatase activity in a biological sample, comprising: contacting in a reaction mix a first test...
US20130116275 INHIBITORS OF HIF AND ANGIOGENESIS  
Inhibitors of the Hypoxia Inducible Factor (HIF) and angiogenesis and their methods of use including the treatment of cancer, hypoxia related pathologies, disorders leading to ischemia, for...
US20130116139 INNATE IMMUNITY MARKERS OF CANCER  
This invention relates generally to methods of determing if a subject has a genetic predisposition to cancer, e.g., prostate cancer and breast cancer.
8435979 Use of imipramine blue and analogs thereof in treating cancers  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
8435972 Method for the treatment of central nervous system cancers and compositions related thereto  
Use of compounds disclosed herein, typically progesterone or analog or derivative thereof, in the treatment of central nervous system cancers, specifically neuroblastoma and glioblastoma is...
8435923 Compositions, materials incorporating the compositions, and methods of using the compositions and materials  
Compositions, materials incorporating the compositions, and methods of use thereof, for the protection and/or decontamination of contaminants are disclosed.
8435493 Imaging agents  
The present invention provides novel amino acid compounds useful in detecting and evaluating brain and body tumors. These compounds have the advantageous properties of rapid uptake and prolonged...
US20130109628 MICRORNA COMPOSITIONS AND METHODS RELATED THERETO  
The disclosure relates to microRNAs (miRNAs) for the prophylaxis and/or treatment of neoplasia. The disclosure relates in particular to sequence corresponding to miR2 and the miR-548 family,...
8430836 Conduit device and system for implanting a conduit device in a tissue wall  
Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in...
8426398 Conjugates of noscapine and folic acid and their use in treating cancer  
The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs),...
US20130095042 SILICA-BASED NANOPARTICLES AND METHODS OF STIMULATING BONE FORMATION AND SUPPRESSING BONE RESORPTION THROUGH MODULATION OF NF-KB  
Osteoporosis, is an exceedingly common malady that leads to bone fracture and results from an imbalance in the rate of osteoblastic bone formation with respect to osteoclastic bone degradation....
8420680 NMDA receptor antagonists for neuroprotection  
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain...
8420354 Methods to manufacture 1,3-dioxolane nucleosides  
This application provides a process for preparing enantiomerically pure β-D-dioxolane nucleosides. In particular, a new synthesis of (−)-DAPD, suitable for large scale development, is described....
US20130085383 SYSTEMS, METHODS AND COMPUTER READABLE STORAGE MEDIA STORING INSTRUCTIONS FOR IMAGE-GUIDED THERAPIES  
Systems, methods, and computer-readable storage media relate to providing image guidance that can improve the accuracy of interventional procedures, such biopsy sampling, for example, by...
US20130073054 TISSUE SUPPORT STRUCTURE  
An apparatus includes a component having a shape memory material. The shape memory material has a first shape including a substantially elongate segment. The shape memory material has a second...
US20130065267 CONJUGATES AND METHODS FOR MEASURING CHAPERONE-MEDIATED AUTOPHAGY  
This disclosure relates to methods of detecting chaperone-mediated autophagy. In some embodiments, the disclosure relates to methods of measuring chaperone-mediated autophagy in living cells and...
US20130064807 USE OF THROMBIN MUTANTS TO INHIBIT THE ANTICOAGULATION EFFECT OF THROMBIN INHIBITORS  
The present disclosure provides methods for inhibiting the anticoagulation effect of a thrombin inhibitor in a patient in need thereof comprising administration of a therapeutically effective...
8394957 9-aminonoscapine and its use in treating cancers, including drug-resistant cancers  
9-aminonoscapine, prodrugs thereof, and pharmaceutically acceptable salts thereof, are disclosed. Pharmaceutical compositions including 9-aminonoscapine, and methods of preparation and use thereof...
8394760 Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof  
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a...
US20130059314 FRET-BASED METHOD FOR THE DETERMINATION OF PROTEIN PHOSPHATASE AND KINASE ACTIVITY  
This disclosure relates to methods of determining activities of protein phosphatases and kinases. The disclosure further relates to methods of clinical monitoring of calcineurin activity and...
US20130045203 Uses of Noscapine and Derivatives in Subjects Diagnosed with FAP  
This disclosure relates to methods of treating or preventing cancer comprising administering a pharmaceutical composition comprising noscapine or noscapine derivatives to a subject diagnosed with...
US20130040947 TRKB AGONISTS AND METHODS OF USE  
Compounds and methods related to the activation of the TrkB receptor are provided. The methods include administering a 7,8-di-hydroxyflavone derivative with modified flavone or heterocyclic ring...
US20130034552 TEMPERATURE SENSITIVE CONJUGATE COMPOSITIONS, AND USES RELATED THERETO  
This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a...
US20130030523 ANNULOPLASTY RINGS AND METHODS FOR HEART VALVE REPAIR  
An annuloplasty ring, configured for implantation in the annulus of a heart valve, comprising multiple segments each of which are geometrically shaped from a three dimensional perspective to...
US20130026248 ORAL HYDRATING MIST APPARATUS  
A hydrating system including a pressurized reservoir configured to hold a volume of liquid; and a hydration delivery attachment that is operably coupled to the pressurized reservoir. The hydrating...
US20130005837 CANCER BIOMARKERS TO PREDICT RECURRENCE AND METASTATIC POTENTIAL  
Described herein are methods for predicting recurrence, progression, and metastatic potential of a prostate cancer in a subject. In certain embodiments, the methods comprise analyzing a sample...
US20130005656 Modified Factor VIII  
Methods of treating patients with Factor VIII deficiency by administration of modified porcine factor VIII are disclosed. The particular modified porcine factor VIII is one in which most of the B...
8343131 Catheter for modified perfusion  
A catheter adapted for use in passing fluids and medicines therethrough for use in the perfusion or reperfusion of blood or blood-fluid mixtures into the arteries, veins, tissues, conduits, or...
US20120328568 COMPOSITIONS AND USES OF LECTINS  
The disclosure relates to uses of a purified or isolated lectin to kill bacteria, viruses, and other pathogens. In certain embodiments, the disclosure relates to method of treating or preventing...