Patents and Patent Applications from Emory University


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US20090296998 Assessing Tumor Response to Therapy  
Systems, methods and computer program products identify first biologic data in a region of interest in a first image and calculate a first biologic volume histogram from the first biologic data....
US20090279736 MAGNETIC RESONANCE EYE TRACKING SYSTEMS AND METHODS  
Embodiments of magnetic resonance eye tracking systems and methods are disclosed. One embodiment, among others, comprises a method that receives magnetic resonance based data and determines...
7615542 Dioxolane thymine and combinations for use against 3TC/AZT resistant strains of HIV  
The present invention relates to the use of a dioxolane thymine compound according to the chemical structure of Formula (I): where R1 is H, an acyl group, a C1-C20 alkyl or ether group, a...
US20090276187 Evaluating Magnetic Resonance Spectra  
Provided are methods, systems and computer program products evaluating magnetic resonance (MR) signals from a sample. The methods and systems can be used to evaluate MR signals from various...
US20090270329 METHODS OF ADMINISTERING PORCINE B-DOMAINLESS FVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20090259099 IMAGE-BASED CONTROL SYSTEMS  
Image-based control systems and methods automate the adjustment of medical devices. An image based-control system for an endoscope can include, in addition to the endoscope, a processing system...
US20090253710 NMDA Receptor Antagonists for Neuroprotection  
Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain...
US20090240041 TUMOR IMAGING COMPOUNDS  
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB)...
US20090239887 Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
US20090234573 Travel Partner Matching Using Selectable Map Interface  
Systems and methods for travel partner matching using a map-based user selectable interface. A user can search for potential travel partner matches using a map-based user selectable interface. In...
US20090234100 OSTEOGENIC COMPOSITIONS COMPRISING AN AMIONO ACID SEQUENCE WHICH IS CAPABLE OF BEING PHOSPHORYLATED BY CAMK2  
Novel osteogenic compositions and methods are provided. In a broad aspect, the composition comprises either a first amino acid sequence which is capable of being phosphorylated by CAMK2; or a...
7588827 Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof  
Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among...
US20090221544 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY VIA A TAPERED ADMINISTRATION PROTOCOL  
The present invention provides methods for the treatment or the prevention of neuronal damage in the CNS. Specifically, the methods of the invention provide for the administration of a...
US20090217402 METHODS AND COMPOSITIONS FOR MODULATING THE ACTIVITY OF PEPTIDASES IN MACROPHAGE AND MACROPHAGE-LIKE CELLS  
Methods and compositions are provided for modulating the activity of macrophage and macrophage-like cells, particularly by modulating the peptidase activity of such cells. In certain aspects,...
US20090208533 NEISSERIA MENINGITIDIS SEROGROUP A CAPSULAR POLYSACCHARIDE ACETYLTRANSFERASE, METHODS AND COMPOSITIONS  
Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the...
7576181 Method of administering porcine B-domainless fVIII  
The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against...
US20090196831 NANOSTRUCTURES, METHODS OF SYNTHESIZING THEREOF, AND METHODS OF USE THEREOF  
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an...
US20090186361 METHODS OF PREDICTING THE PHARMACEUTICAL TOXICITY OF TAXANES  
The present disclosure relates to methods of identifying a recipient subject who has an elevated risk of an adverse or toxic reaction to a taxane. The predictive methods of the present disclosure...
7563775 Insulin-responsive DNA binding protein-1 and methods to regulate insulin-responsive genes  
The present invention relates to the novel protein Insulin-Responsive DNA Binding Protein-1 (IRDBP-1) and nucleotide sequences that encode it. IRDBP-1 binds to nucleic acid regions of genes that...
US20090181397 PREDICTIVE AND DIAGNOSTIC METHODS FOR CANCER  
The present disclosure encompasses methods of diagnosing the presence of a cancer, and particularly a cancer of prostate or breast tissue, in a human subject, predicting the outcome or severity of...
7560107 Modified factor VIII  
Modified porcine factor VIII is disclosed in which most of the B domain has been removed through genetic engineering. This modified factor VIII is particularly useful for treatment of...
US20090176745 TRIARYLMETHANE ANALOGS AND THEIR USE IN TREATING CANCERS  
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and...
7557139 Triptolide analogs for the treatment of autoimmune and inflammatory disorders  
The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of...
US20090169861 POROUS MATERIALS EMBEDDED WITH NANOSPECIES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF  
Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a...
7550299 Method for predicting onset/risk of atrial fibrillation (AF)  
A method for predicting onset or risk of atrial fibrillation in a subject includes determining the presence of an oxidative stress marker, such as glutathione, cysteine, and/or a derivative of a...
US20090149416 2' and 3'-Substituted Cyclobutyl Nucleoside Analogs for the Treatment Viral Infections and Abnormal Cellular Proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
7544715 Tumor imaging compounds  
The invention provides novel amino acid compounds of use in detecting and evaluating brain and body tumors. These compounds combine the advantageous properties of α-aminoisobutyric acid (AIB)...
7537902 Methods and kits using a molecular interaction between a Smurf-1 WW domain and LIM mineralization protein isoforms  
The instant application provides kits and methods for identifying agents which induce or inhibit the osteogenic effect of LMP or BMP proteins. The kits are directed to methods which measure either...
US20090130034 RE-ENGINEERED UV DAMAGE ENDONUCLEASE, COMPOSITIONS AND METHODS  
Provided are methods and compositions for reducing damage to skin by ultraviolet light and other agents that cause distortion to double stranded DNA and methods for reducing damage to other organs...
US20090123365 Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof  
A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a...
7524936 Mitogenic oxygenase regulators  
The present invention relates to new genes encoding for the production of novel nox enzyme proteins involved in generation of reactive oxygen intermediates that affect cell division. The present...
US20090105181 Modulation of sodium channels by nicotinamide adenine dinucleotide  
The present invention relates to the use of oxidized nicotinamide adenine dinucleotide (NAD+) or of its reduced form, NADH, as sodium channel modulators. The present invention also relates to the...
US20090099194 CXCR4 Antagonists Including Diazine And Triazine Structures For The Treatment Of Medical Disorders  
The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative...
7517866 LIM mineralization protein splice variants  
The present invention is directed to isolated nucleic acid molecules that encode LIM mineralization protein, or LMP. The invention further provides vectors comprising splice variants of nucleotide...
US20090092998 MARKER FOR ARRHYTHMIA RISK  
The present invention relates to markers and methods for determining risk of ventricular arrhythmia in an individual. By using the markers of the present invention, individual with high risk of...
7504374 Method for inducing deposition and maturation of bone comprising a co-therapeutic regimen of LMP-1 and BMP-2  
The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic...
US20090054313 METHOD FOR INDUCING DEPOSITION AND MATURATION OF BONE COMPRISING A CO-THERAPEUTIC REGIMEN OF LMP-1 AND BMP-2  
The present invention relates to the methods and compositions for the treatment of subjects having compromised bone conditions. Specifically, the invention relates to combinatorial therapeutic...
7495006 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation  
Provided are cyclobutyl nucleosides and methods for their use in treatment of infections including Retroviridae (including HIV), Hepadnaviridae (including HBV), or Flaviviridae (including BVDV and...
US20090042195 METHODS AND SYSTEMS FOR SCREENING FOR AND DIAGNOSING DNA METHYLATION ASSOCIATED ABNORMALITIES AND SEX CHROMOSOME ANEUPLOIDIES  
Methods and systems for population screening and diagnostics are provided. In particular methods and systems for population screening of individuals for genetic disorders due to alterations in DNA...
US20090035827 O-acetyltransferase from Neisseria Meningitidis, Compositions and Methods  
Provided are recombinant DNA molecules that do not occur in nature encoding a Lot3 O-acetyltransferase, vectors that direct expression of a Lot O-acetyltransferase, recombinant host cells which...
US20090023791 PH-dependent NMDA receptor antagonists  
NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neurprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events...
US20090018209 CURCUMIN AND CURCUMINOID INHIBITION OF ANGIOGENESIS  
Methods for treating diseases or disorders of the skin which are characterized by angiogenesis have been developed using curcumin and curcumin analogs. Based on the results obtained with curcumin,...
US20090018167 Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states  
The present invention relates to chalcone and chalcone derivatives and analogs which are useful as angiogenesis inhibitors. The present compounds, which are inexpensive to synthesize, exhibit...
US20090011991 Novel Curcuminoid-Factor VIIA Constructs as Suppressors of Tumor Growth and Angiogenesis  
The fluorinated curcuminoid (3,5-bis-(2-fluorobenzylidene)-piperidin-4-one-acetate is about ten times more effective at arresting the growth of tumor cells than cisplatin. Conjugates for...
7473687 Methods for the treatment of a traumatic central nervous system injury  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
US20080318914 METHODS FOR THE TREATMENT OF A TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY  
Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a...
7468436 Method of resolution and antiviral activity of 1,3-oxathiolane nucleoside enantiomers  
A process for the resolution of a racemic mixture of nucleoside enantiomers that includes the step of exposing the racemic mixture to an enzyme that preferentially catalyzes a reaction in one of...
7468357 Nucleosides with anti-hepatitis B virus activity  
A method for the treatment of a host, and in particular, a human, infected with hepatitis B virus (HBV) is provided that includes administering an effective amount of a β-L-nucleotide, optionally...
US20080312279 Compositions for Treating Fragile X and Other Disorders Methods of Use Thereof, and Screening for Compounds for Fragile X and Other Disorders  
Methods of screening compounds, active compositions, pharmaceutical compositions, methods of treating disorders, methods of preventing disorders, and kits to screen a library of compounds, are...
US20080306326 Drive Circuit For Magnetic Stimulation  
The inventive technique includes devices and methods for generating a magnetic field. One such device may include an inductor for generating a magnetic field and a power source for providing...