Patents and Patent Applications from Eastern Virginia Medical School


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US20170319843 APPARATUS FOR GENERATING ELECTRICAL PULSES AND METHODS OF USING THE SAME  
A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an...
US20170275591 METHODS OF PRESERVING AND PROTECTING PANCREATIC BETA CELLS AND TREATING OR PREVENTING DIABETES BY INHIBITING NOX-1  
Methods of preserving and/or protecting pancreatic beta cells by inhibiting NOX-1. In a further aspect, NOX-1 inhibitors are administered to a subject in order to preserve and/or protect beta...
9738678 Substituted nucleoside derivatives with antiviral and antimicrobial properties  
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers,...
9688960 Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting NOX-1  
Methods to preserve and/or protect beta cell function by contacting a population or preparation of pancreatic cells, beta cells and/or islets with an inhibitor of NADPH oxidase-1 (NOX-1). Methods...
9603602 Uterine compression devices and methods  
Disclosed are devices for reducing postpartum hemorrhage, including a belt having a fastener for securing the belt around a patient's body, a bladder being inflatable with air and adapted to be...
US20170007436 UTERINE COMPRESSION DEVICES AND METHODS  
Disclosed are devices for reducing postpartum hemorrhage, including a belt having a fastener for securing the belt around a patient's body, a bladder being inflatable with air and adapted to be...
US20170001955 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase  
Human lipoxygenases (LOXs) are a family of iron-containing enzymes involved in catalyzing the oxidation of polyunsaturated fatty acids to provide the corresponding bioactive...
US20160376322 Derivative Peptide Compounds and Methods of Use  
The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and...
US20160311856 PEPTIDE COMPOUNDS TO REGULATE THE COMPLEMENT SYSTEM  
The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived...
US20160311843 SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES  
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers,...
9422337 Peptide compounds to regulate the complement system  
The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived...
9386973 Magnaretractor system and method  
A system and method for performing surgical procedures within a body cavity, e.g. abdomen, uses a magnetized device is utilized to allow a surgeon to control intra-abdominal organs and objects....
9381301 Systems and methods for monitoring and controlling internal pressure of an eye or body part  
Systems and methods for automatically monitoring and controlling pressure in a body part are disclosed. The systems include an implantable tube with one open end of the tube implanted in the body...
9296776 Substituted nucleoside derivatives with antiviral and antimicrobial properties  
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers,...
9283182 Topical antiviral formulations  
The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (NRTIs), preferably [2-(6-Amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid (tenofovir, PMPA),...
US20160052979 FAMILY OF SYNTHETIC POLYNUCLEOTIDE-BINDING PEPTIDES AND USES THEREOF  
The present invention provides novel synthetic peptides (including the TZIP peptide) as oncogenic and genetic modulators, including genetics of viruses, as well as methods of making and using the...
US20160030569 LOW-GLYCERIN FORMULATIONS FOR HIV TREATMENT AND PREVENTION  
The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (NRTIs), preferably [2-(6-Amino-pur: in-9-yl)-1-methyl-ethoxymethy]-phosphonic acid (tenofivir, PMPA),...
US20160015971 NANOSECOND PULSED ELECTRIC FIELDS CAUSE MELANOMAS TO SELF-DESTRUCT  
Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the...
US20160010061 METHODS OF PRESERVING AND PROTECTING PANCREATIC BETA CELLS AND TREATING OR PREVENTING DIABETES BY INHIBITING NOX-1  
Methods of preserving and/or protecting pancreatic beta cells by inhibiting NOX-1. In a further aspect, NOX-1 inhibitors are administered to a subject in order to preserve and/or protect beta...
US20150374533 UTERINE COMPRESSION DEVICES AND METHODS  
Disclosed are devices for reducing postpartum hemorrhage, including a belt having a fastener for securing the belt around a patient's body, a bladder being inflatable with air and adapted to be...
US20150366795 TOPICAL ANTIVIRAL FORMULATIONS  
The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (NRTIs), preferably [2-(6-Amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid (tenofovir, PMPA),...
9168373 Nanosecond pulsed electric fields cause melanomas to self-destruct  
Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nsPEFs”) are provided. In one embodiment of the invention, the...
9060933 Topical antiviral formulations  
The present invention relates to formulations of nucleotide reverse transcriptase inhibitors (NRTIs), preferably [2-(6-Amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid (tenofovir, PMPA),...
US20150160224 QUANTITATION OF BIOMARKERS FOR THE DETECTION OF PROSTATE CANCER  
The present invention provides biomarkers that are useful in determining whether a subject has cancer, specifically prostate cancer. Specifically, betaine, malate, proline, N-acetylaspartate,...
US20150133392 Peptide Compounds to Regulate the Complement System  
The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived...
US20150079565 AUTOMATED INTELLIGENT MENTORING SYSTEM (AIMS)  
Methods, systems, and non-transitory computer program products are disclosed. Embodiments of the present, invention can include providing a performance model of a procedure, the performance model...
8980548 Methods and reagents for metabolomics and histology in a biological sample and a kit for the same  
A method of extracting and measuring one or more biochemicals from a biological sample, comprises immersing the biological sample in an organic solvent, whereby one or more biochemicals present in...
8906845 Peptide compounds to regulate the complement system  
The disclosure provides peptide compounds that regulate the complement system and methods of using these compounds. Specifically the disclosure provides an isolated, purified peptide of 30 amino...
8882511 System, method and medium for simulating normal and abnormal medical conditions  
The present invention provides a system, method and medium for simulating medical conditions to facilitate medical training, that utilizes a roaming device configured to be mobile; a positioning...
8822222 Apparatus for generating electrical pulses and methods of using same  
A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an...
8796336 Methoxypolyethylene glycol chelate and uses thereof  
The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or...
US20140106430 ACTIVATION AND AGGREGATION OF HUMAN PLATELETS AND FORMATION OF PLATELET GELS BY NANOSECOND PULSED ELECTRIC FIELDS  
Methods for forming activated platelet gels using nsPEF's and applying the activated gels to wounds, such as heart tissue after myocardial infarction. The platelets are activated by applying at...
US20140066695 MAGNARETRACTOR SYSTEM AND METHOD  
A system and method for performing surgical procedures within a body cavity, e.g. abdomen, uses a magnetized device is utilized to allow a surgeon to control intra-abdominal organs and objects....
US20140046140 CERCLAGE SUTURE REMOVAL DEVICE  
A device for removing a cerclage suture has a shaft sized and shaped to extend from a proximal end outside a vagina to a distal end near a cervix. The shaft also has a blunt end located at the...
8602981 Magnaretractor system and method  
A system and method for performing surgical procedures within a body cavity, e.g. abdomen, uses a magnetized device is utilized to allow a surgeon to control intra-abdominal organs and objects....
8573221 Cervical occluder  
A device for occluding a cervix has an elongated conduit sized and shaped to extend from a proximal end outside the vagina to a distal end near the cervix. A loop sized to fit around an exocervix...
8552064 Suramin and derivatives thereof as topical microbicide and contraceptive  
The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing...
US20130244924 PEPTIDE COMPOUNDS TO REGULATE THE COMPLEMENT SYSTEM  
The disclosure provides peptide compounds that regulate the complement system and methods of using these compounds. Specifically the disclosure provides an isolated, purified peptide of 30 amino...
US20130096159 INHIBITORS OF HUMAN 12-LIPOXYGENASE  
Disclosed are inhibitors of human 12-lipoxygenase of Formula (I) or (II), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating or preventing a 12-lipoxygenase mediated...
8403842 Transvaginal ultrasound probe speculum  
A transvaginal ultrasound probe speculum is designed for use with a generally cylindrical elongated ultrasound probe. The speculum has an elongated blade having a proximal end and a distal end,...
US20130058972 METHODS FOR REGULATING COMPLEMENT CASCADE PROTEINS USING ASTROVIRUS COAT PROTEIN AND DERIVATIVES THEREOF  
The present invention provides a method for modulating the complement cascade by depleting the plasma of the functional activity of complement proteins and thereby reducing or eliminating...
8348938 Apparatus, systems and methods for treating a human tissue condition  
Apparatus, systems and methods for providing electrical energy to treat a tissue condition includes a high voltage pulse generator for generating short high voltage pulses of energy and a delivery...
US20120315704 APPARATUS FOR GENERATING ELECTRICAL PULSES AND METHODS OF USING THE SAME  
A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an...
8323025 System and method for automatic driver evaluation  
Embodiments of the present invention provide a system and method for automatic driver evaluation of a person's driving capabilities and render an outcome of pass or fail without the need for a...
8297977 System and method for automatic driver evaluation  
Embodiments of the present invention provide a system and method for automatic driver evaluation of a person's driving capabilities and render an outcome of pass, fail, or pass with restrictions...
US20120247481 CERVICAL OCCLUDER  
A device for occluding a cervix has an elongated conduit sized and shaped to extend from a proximal end outside the vagina to a distal end near the cervix. A loop sized to fit around an exocervix...
8241843 Methods for regulating complement cascade proteins using astrovirus coat protein and derivatives thereof  
The present invention provides a method for modulating the complement cascade by depleting the plasma of the functional activity of complement proteins and thereby reducing or eliminating...
US20120016030 METHOXYPOLYETHYLENE GLYCOL THIOESTER CHELATE AND USES THEREOF  
The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or...
8083678 System, method and medium for acquiring and generating standardized operator independent ultrasound images of fetal, neonatal and adult organs  
A system, method and medium for standardizing a manner of acquisition and display of ultrasound images. In one embodiment of the invention, a volumetric image of an organ is acquired in a...
US20110236979 Apparatus for Generating Electrical Pulses and Methods of Using Same  
A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an...
Matches 1 - 50 out of 145 1 2 3 >