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8163521 |
Self-assembled proteins and related methods and protein structures
The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences...
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US20110319370 |
Combination Hormone Therapy for the Eye
An ophthalmic instillation composition which contains melatonin and at least one other hormone, typically an estrogen but also possibly testosterone or another aromatasable androgen. The...
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US20110269940 |
Self-Assembled Proteins and Related Methods and Protein Structures
The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences...
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8030319 |
Methods for treating cancer and other pathological proliferating disorders by inhibiting mitosis using pyrrolo[2 3-d]pyrimidines
The present invention provides methods for treating cancer and other pathological proliferating conditions by inhibiting mitosis using at least one pyrrolo[2,3-d]pyrimidine having the general...
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US20110207757 |
Tricyclic Compounds Having Cytostatic and/or Cytoxic Activity and Methods of Use Thereof
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase...
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7982035 |
Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for...
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7981902 |
Substituted pyrrolo[2,3-d]pyrimidines for selectively targeting tumor cells with FR type receptors
A compound for treating cancer tumors, particularly ovarian cancer tumors, is described, where a fused cyclic pyrimidine having a cancer treating ability is effective to allow selective delivery to...
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7960400 |
Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase...
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US20110117193 |
ANTIRETROVIRAL DRUG FORMULATIONS FOR TREATMENT OF CHILDREN EXPOSED TO HIV/AIDS
The present disclosure provides fast disintegrating formulations for the treatment of human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) in patients such as neonatal,...
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7888506 |
Composition, synthesis, and use of a new class of fluorophores
A new class of fluorophores is presented. The fluorophores include a conjugated ring system, such as a dithiolone, a pyran, and a pyrazine containing ring system. The structure is designed with the...
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7879578 |
Self-assembled proteins and related methods and protein structures
The present invention provides user-directed construction of novel specific homo- and hetero-dimeric, and multimeric assemblages of proteins. The present invention is comprised of gene sequences...
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US20100041158 |
Lead sensor and methods of use
A fluorophore that forms a complex with Pb ions is disclosed. The fluorophore/lead complex fluoresces with an intensity greater than complexes formed by the fluorophore with other metals. The...
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US20090326224 |
THIENO PYRIMIDINE COMPOUNDS
A compound for treating cancer tumors, particularly ovarian cancer tumors, is described, where a fused cyclic pyrimidine having a cancer treating ability is effective to allow selective delivery to...
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7528950 |
Tunable laser-based process monitoring apparatus
A chemical imaging and process monitoring device which utilizes a computer controlled tunable laser to provide light at discrete wavelengths in the near infrared band and a focal plane array to...
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7525654 |
Tunable laser-based chemical imaging system
A chemical imaging device which utilizes a computer controlled tunable laser to provide light of wavelengths in the near infrared band and a focal plane array to image a sample illuminated at...
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US20080182337 |
COMPOSITION, SYNTHESIS, AND USE OF A NEW CLASS OF FLUOROPHORES
A new class of fluorophores is presented. The fluorophores include a conjugated ring system, such as a dithiolone, a pyran, and a pyrazine containing ring system. The structure is designed with the...
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US20080045710 |
Chemotherapeutic compounds for selectively targeting tumor cells with FR type receptors
A compound for treating cancer tumors, particularly ovarian cancer tumors, is described, where a fused cyclic pyrimidine having a cancer treating ability is effective to allow selective delivery to...
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US20080045552 |
Methods of using selective chemotherapeutic agents for targeting tumor cells
A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing...
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7135175 |
Compositions and methods for eliciting an immune response to gram-negative bacterial infections
Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the...
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7132101 |
Compositions and methods for eliciting an immune response to gram-negative bacterial infections
Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the...
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US20060152729 |
Tunable laser-based process monitoring apparatus
A chemical imaging and process monitoring device which utilizes a computer controlled tunable laser to provide light at discrete wavelengths in the near infrared band and a focal plane array to...
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US20060082777 |
Tunable laser-based chemical imaging system
A chemical imaging device which utilizes a computer controlled tunable laser to provide light of wavelengths in the near infrared band and a focal plane array to image a sample illuminated at...
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US20060018916 |
Compositions and methods for eliciting an immune response to gram-negative bacterial infections
Compositions for eliciting an immune response against Gram-negative bacterial infections and methods of making such compositions are provided. The composition comprises glycosylated pilin, the...
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6962920 |
Pyrimidine derivatives and methods of making and using these derivatives
This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness....
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6790673 |
Speciated isotope dilution mass spectrometry of reactive species and related methods
A method of speciated isotope dilution mass spectrometry (SIDMS) which will permit determination of concentrations of one or more species from a sample even if the sample has been subjected to...
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6770652 |
Multiple acting anti-angiogenic and cytotoxic compounds and methods for using the same
This invention discloses pyrrolo pyrimidine compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, of the following formula (3): These compounds are useful in...
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6716880 |
Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an...
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6696455 |
Pyrimidine derivatives and methods of making and using these derivatives
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include...
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6638923 |
Estra-1,3,5(10),16-tetraene derivatives
Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I): (wherein R1 is as defined by the present specification.
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6566347 |
Controlled release pharmaceutical
The present invention provides a controlled release pharmaceutical composition comprising a polydextrose, a drug that is complexed with the polydextrose, and a polymer matrix having the drug...
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US20030083309 |
CONTROLLED RELEASE PHARMACEUTICAL
The present invention provides a controlled release pharmaceutical composition comprising a polydextrose, a drug that is complexed with the polydextrose, and a polymer matrix having the drug...
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6537999 |
Pyrimidine derivatives and methods of making and using these derivatives
This invention discloses pyrimidine derivatives, and pharmaceutically acceptable salts and prodrugs thereof, of the following formula: wherein L and M are selected from the group consisting of...
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6518426 |
Pyrimidine derivatives and methods of making and using these derivatives
Novel pyrrolo[3,2-d]pyrimidine derivatives of the following general formula are disclosed. These compounds are useful in the treatment of bacterial infections such as Toxoplasmosis gondii and...
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6436918 |
Steroid sulfatase inhibitors and methods for making and using the same
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position....
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6433000 |
Compounds for the treatment of estrogen-dependent illnesses and methods of making and using the same
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an...
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6423720 |
Pyrimidine compounds and methods for making and using the same
This invention discloses compounds, and pharmaceutically acceptable salts, solvates and prodrugs thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such...
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6420370 |
Pyrimidine derivatives and method of making and using derivatives
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include...
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6399595 |
Steroid sulfatase inhibitors and methods for making and using the same
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position....
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6397205 |
Document categorization and evaluation via cross-entrophy
A computerized data processing system for categorizing documents that applies candidate functions, such as entropy, cross-entropy, and KL-distance, to data classification is disclosed. A...
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6376687 |
Steroid sulfatase inhibitors and methods for making and using the same
Novel sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position....
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6288107 |
Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an...
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6288050 |
Steroid sulfatase inhibitors and methods for making and using the same
Sulfatase inhibitor compounds useful in the treatment of estrogen dependent illnesses are disclosed. These compounds generally comprise a steroid nucleus substituted at the C17 position. Methods...
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6262043 |
Estra-1,3,5(10),16-tetraene derivatives
Estra-1,3,5(10),16-tetraene derivatives represented by the following formula (I): ##STR1##(wherein R1 represents hydroxy, alkoxy, or NR2 R3 (wherein R2 and R3 are the same or different, and each...
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6248780 |
Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
Novel sulfatase inhibitor/estrogen receptor blocker compounds useful in the treatment of estrogen dependent illnesses are disclosed. The compounds generally comprise a sulfamate moiety and an...
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6221872 |
Pyrimidine derivatives and methods of making and using these derivatives
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include...
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6156340 |
Orally administrable time release drug containing products
A time release orally administrable drug containing product comprising a core, a drug layer attached to the core, and first and second coating layers is disclosed. The first coating layer is...
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6114339 |
Derivatives of pyrido [2,3-D] and [3,2-D] pyrimidine method of using these derivatives
The invention also discloses compounds and pharmaceutically acceptable salts having the generic formula (2) ##STR1## wherein X and Y may be the same or different and are selected from the group...
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6103727 |
Pyrimidine derivatives and methods of making and using these derivatives
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include...
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6096750 |
Furopyrimidines and methods of making and using the same derivatives
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include...
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6077844 |
Pyrimidine derivatives and methods of making and using these derivatives
This invention discloses compounds, and pharmaceutically acceptable salts thereof, useful in therapeutically and/or prophylactically treating patients with an illness. Such illnesses include...
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