Patents and Patent Applications from Duquesne University


Matches 1 - 50 out of 186 1 2 3 4 >
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9777012 Substituted furo[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents  
Compounds of Formula I: and compounds of Formula II: are provided. Pharmaceutical compositions comprising either the compound of Formula I or Formula II are disclosed. Methods of treating patients...
US20170260190 SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE  
This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts,...
US20170253612 PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE  
The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is...
US20170246170 Tricyclic Compounds Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example...
9732090 Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient  
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a...
9688690 Pyrimidine compounds and pyrimido indole compounds and methods of use  
The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is...
US20170153180 COMPOSITIONS, METHODS AND DEVICES THEREOF FOR FLUORESCENT ANALYSIS OF GUNSHOT RESIDUE  
The present disclosure relates to lead ion sensors for testing, detecting and analyzing particle-containing samples for gunshot residue. The lead ion sensors include a fluorophore itself or a...
9650384 Substituted pyrimidine compounds and methods of use and manufacture  
This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts,...
US20170114066 Selective Proton Coupled Folate Transporter and Folate Receptor, and Garftase Inhibitor Compounds and Methods of Using the Same  
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula I: These...
9624178 Substituted cyclopenta pyrimidine bicyclic compounds having antitmitotic and/or antitumor activity methods of use thereof  
The present invention provides substituted cyclopenta and cyclopentyl pyrimidine bicyclic compounds of Formula III, and 5,6-saturated and unsaturated and pharmaceutically acceptable salts,...
US20170096388 CARBOXYLIC ACID ESTER PRODRUG INHIBITORS OF MEK  
The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or...
US20170050978 Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same  
The present invention provides a compound of Formula I: wherein R is H, a methyl group, an ethyl group, a n-propyl group, an iso-propyl group, or a n-butyl group; and R1 is H, a 4′-methyl group, a...
9578201 Method of detecting steganographically hidden images via low-order bit comparisons  
The invention is a method for scanning an image data file to determine the presence of a payload, including the steps of identifying the values of one or more lower-order bits in the bytes of an...
9556198 Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example...
9556112 Carboxylic acid ester prodrug inhibitors of MEK  
The invention generally relates to compounds having structure I: wherein x represents alkyl, aryl or het-aryl, each of y independently represents hydrogen or halogen and z represents hydrogen or...
US20170022217 Tricyclic Compounds Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for...
US20170015672 SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES FOR SELECTIVELY TARGETING TUMOR CELLS WITH FR-ALPHA AND FR-BETA TYPE RECEPTORS  
Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate...
9530049 Kinetic-based tool for biometric identification, verification, validation and profiling  
A method for identifying an animal or human, including the steps of collecting and retaining an archive data set of measurements of two or more kinetic stylometrics of a first individual animal or...
9519776 Computer security system and method  
The present invention is a computer security system and method in which the various algorithms not only do not search for or detect the presence of a steganographic or other hidden image in a data...
US20160355520 Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof  
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase...
9511069 Selective proton coupled folate transporter and folate receptor, and GRAFTase inhibitor compounds and methods of using the same  
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed having the general Formula 1: These...
US20160338984 PARTICLE FORMULATIONS OF ALL-TRANS RETINOIC ACID AND TRANSFORMING GROWTH FACTOR BETA FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS  
Particle formulations are disclosed that include polymeric particles containing a small molecule drug and a high molecular weight therapeutic protein. Methods of making and using the particle...
9481678 Substituted pyrrolo[2,3-D]dipyrimidines for selectively targeting tumor cells with FR-alpha and FR-beta type receptors  
Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate...
9481645 Composition, synthesis, and use of a new class of isonitriles  
This invention relates to novel isonitriles, including arylthio isonitriles, and methods for their preparation. The isonitriles include a conjugated ring system. The structure is designed with the...
US20160304525 Cyclopenta[d]pyrimidines And Substituted Cyclopenta[d]pyrimidines As Antitubulin and Microtubule Targeting Agents, Monocyclic Pyrimidines As Tubulin Inhibitors, And Pyrrolopyrimidines As Targeted Antifolates And Tubulin and Multiple Receptor Tyrosine Kinase Inhibition And Antitumor Agents  
The present invention provides a compound of Formula I, and salts thereof, and a pharmaceutical composition comprising a compound of Formula I: wherein R1 is selected from the group consisting of...
9458167 Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for...
9446045 Methods of using selective chemotherapeutic agents for targeting tumor cells  
A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing...
US20160269589 A Method of Detecting Steganographically Hidden Images Via Low-Order Bit Comparisons  
The invention is a method for scanning an image data file to determine the presence of a payload, including the steps of identifying the values of one or more lower-order bits in the bytes of an...
9422297 Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof  
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase...
US20160229857 SUBSTITUTED PYRROLO[2,3-D]DIPYRIMIDINES FOR SELECTIVELY TARGETING TUMOR CELLS WITH FR-ALPHA AND FR-BETA TYPE RECEPTORS  
Pyrrolo[2,3-d]pyrimidine derivatives, and pharmaceutical acceptable salts thereof, useful in therapeutically treating patients with cancer are disclosed. These compounds selectively target folate...
US20160221975 NOVEL ANTHRANILIC AMIDES AND THE USE THEREOF  
Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the...
US20160176891 Conformationally Restricted 4-Substituted-2,6-dimethylfuro[2,3-d]pyrimidines as Multi-targeted Receptor Tyrosine Kinase Inhibitors and Microtubule Targeting Antitumor Agents  
Compounds of Formula I: and compounds of Formula II: are provided. Pharmaceutical compositions comprising either the compound of Formula I or Formula II are disclosed. Methods of treating patients...
9370526 Combination hormone replacement therapy (HRT) and melatonin to prevent and treat mammary cancer  
A combination hormone and melatonin therapy is provided to reduce the risk of developing, or to reduce the severity of, breast cancer by administering at least one estrogen hormone and optionally...
US20160097754 MERCURY SENSOR AND METHODS OF USE  
The invention relates to non-fluorescent or low-fluorescent compounds for contact with mercury ions to produce fluorescent compounds as a detector for mercury. The fluorescence produced by the...
9266889 Composition, synthesis, and use of new substituted pyran and pterin compounds  
The present invention relates to substituted pterin compounds, their synthesis and use. In particular, the present invention relates to a new precursor compound and its analogs for synthesizing a...
US20160039840 Pyrimidine Compounds and Pyrimido Indole Compounds and Methods of Use  
The present invention discloses a compound comprising the formula: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, or a compound of the formula wherein the S is...
US20160039830 Substituted Pyrimidine Compounds and Methods of Use and Manufacture  
This invention provides substituted pyrimidine compounds having the formula: wherein X is absent, CH2, S, or O, and R is an alkyl group having from one to ten carbon atoms, and optionally salts,...
US20160009731 Bicyclic and Tricyclic Pyrimidine Tyrosine Kinase Inhibitors with Antitubulin Activity and Methods of Treating a Patient  
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a...
US20150284398 Substituted Bicyclic Pyrimidine Compounds with Tubulin and Multiple Receptor Inhibition  
This invention provides substituted bicyclic pyrimidine compounds and pharmaceutically acceptable salts, hydrates, and solvates of the compounds, each having tubulin and multiple receptor...
9139590 Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating a patient  
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present invention possess dual activity in a...
US20150252053 Tricyclic Compounds Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for...
US20150239835 COMPOSITION, SYNTHESIS, AND USE OF A NEW CLASS OF ISONITRILES  
This invention relates to novel isonitriles, including arylthio isonitriles, and methods for their preparation. The isonitriles include a conjugated ring system. The structure is designed with the...
US20150239833 COMPOSITION, SYNTHESIS, AND USE OF NEW ARYLSULFONYL ISONITRILES  
This invention relates to novel isonitriles, including arylsulfonyl isonitriles, and methods for their synthesis. The isonitriles include a conjugated ring system. The structure is designed with...
US20150232477 Tricyclic Compounds Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example...
US20150203497 COMPOSITION, SYNTHESIS, AND USE OF NEW SUBSTITUTED PYRAN AND PTERIN COMPOUNDS  
The present invention relates to substituted pterin compounds, their synthesis and use. In particular, the present invention relates to a new precursor compound and its analogs for synthesizing a...
US20150193653 Kinetic-based tool for biometric identification, verification, validation and profiling  
A method for identifying an animal or human, including the steps of collecting and retaining an archive data set of measurements of two or more kinetic stylometrics of a first individual animal or...
9056869 Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for...
9045489 Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof  
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for...
US20150141445 Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof  
The present invention provides tricyclic compounds having cytostatic and cytotoxic activity in a single molecule having receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase...
US20150126536 Methods of Using Selective Chemotherapeutic Agents for Targeting Tumor Cells  
A method for treating cancer tumors, particularly ovarian cancer tumors, is described, where fused cyclic pyrimidine having a cancer treating ability is selectively delivered to an FR expressing...
Matches 1 - 50 out of 186 1 2 3 4 >