Patents and Patent Applications from Duke University


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10022719 Droplet manipulation device  
Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements,...
10022233 Orthopedic implant for sustained drug release  
An orthopedic implant device has a bone-replacement contour that replicates a healthy bone surface contour. An exterior surface of the device has elution pores. Interior surfaces of the device...
US20180195132 OLIGODENDROGLIOMA DRIVE GENES  
Oligodendrogliomas are the second most common malignant brain tumor in adults. These tumors often contain a chromosomal abnormality involving a pericentromeric fusion of chromosomes 1 and 19,...
US20180194778 ANTIMICROBIAL PROCHELATORS TO TARGET DRUG-RESISTANT BACTERIA AND METHODS OF MAKING AND USING THE SAME  
The present disclosure provides antibacterial prodrugs and methods of making and using the same.
10017773 HSF-like transcription factor, TBF1, is a major molecular switch for growth-to-defense transition in plants  
The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from regions comprising binding sites for...
10017739 Methods of expanding and assessing B cells and using expanded B cells to treat disease  
Provided herein are methods of expanding B cells, and in particularly B10 cells capable of producing IL-10, ex vivo. The methods include incubation of harvested B cells in the presence of IL-21....
10016756 Disposable pipette tip and methods of use  
A kit for detection of an analyte of interest in a liquid sample, and methods of using, are provided. The kit may include a pipette and a disposable pipette tip configured to engage the pipette....
US20180185471 POLYVALENT VACCINE  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
US20180185457 TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE II  
Methods of treating glycogen storage disease type II, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II.
10004800 Antibody evolution immunogens  
The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the...
10004464 System for improved compressive tomography and method therefor  
A method and system for forming tomographic images of an object using discrete, non-continuous illumination rays is disclosed. In some embodiments, coded apertures, collimation filters, or...
10004397 Method and system for improving aiming during optical coherence tomography on young children by synchronization with retinal bifringence scanning  
The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by...
US20180174490 METHODS AND SYSTEMS FOR GENERATING FLUID SIMULATION MODELS  
Systems and methods for generating three-dimensional fluid flow simulations from two-dimensional (2D) image data are provided. Data is segmented from 2D images of a sample having a biological...
US20180170130 NON-REGULAR ELECTRICAL STIMULATION PATTERNS FOR TREATING NEUROLOGICAL DISORDERS  
Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20180169433 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES  
Psoralen compounds of compounds having formulae 1A-10A, 1B-10B, 1C-10C, 1D-10D, 1E-10E, 1F-10F, 1G-10G, and 1H-5H as shown in FIG. 1, and pharmaceutically acceptable salts thereof; and their use...
10000469 Heat shock protein 70 (hsp-70) receptor ligands  
Inducible HSP70 is overexpressed in a wide spectrum of human tumors and its expression correlates with metastasis and poor outcomes to radiation and chemotherapy in patients. Identification of...
9999620 CaMKK-β as a target for treating cancer  
Provided herein are compounds, compositions, including pharmaceutical compositions, having anti-cancer activity. Also provided are methods for diagnosing, detecting, and treating cancer in a...
US20180161423 LIPOSOME-PEPTIDE CONJUGATE AND METHOD OF USING SAME TO INDUCE PRODUCTION OF ANTI-HIV ANTIBODIES  
The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions...
9998666 Systems and methods for burst image deblurring  
System and Method for automatically removing blur and noise in a plurality of digital images. The system comprises an electronic processor configured to receive the plurality of digital images,...
9994548 Phenyl-substituted nicotinic ligands, and methods of use thereof  
Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety,...
9993465 2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof  
Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic...
US20180156804 METHODS OF DEVELOPING A PROGNOSIS FOR PANCREATIC CANCER AND PREDICTING RESPONSIVENESS TO CANCER THERAPEUTICS  
Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided herein. The methods include detecting the expression level of at...
US20180155763 NON-FOULING POLYMERIC SURFACE MODIFICATION AND SIGNAL AMPLIFICATION METHOD FOR BIOMOLECULAR DETECTION  
An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a...
US20180155423 Bispecific Molecules That Are Immunoreactive With Immune Effector Cells That Express An Activating Receptor And An Antigen Expressed By A Cell Infected By A Virus And Uses Thereof  
The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby...
US20180154178 PHOSPHOR-CONTAINING DRUG ACTIVATOR ACTIVATABLE BY A MONTE CARLO DERIVED X-RAY EXPOSURE, SYSTEM CONTAINING THE ACTIVATOR, AND METHODS FOR USE  
A phosphor-containing drug activator activatable from a Monte Carlo derived x-ray exposure for treatment of a diseased site. The activator includes an admixture or suspension of one or more...
US20180153982 COMPOSITIONS, METHODS AND KITS FOR ELICITING AN IMMUNE RESPONSE  
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing...
US20180153952 COMPOSITIONS AND METHODS FOR TREATING POST OPERATIVE COGNITIVE DYSFUNCTION AND NEUROINFLAMMATION WITH ANNEXIN A1 (ANXA1) PEPTIDES  
The present disclosure provides compositions and methods for treating post-operative cognitive dysfunction with Annexin A1 (ANXA1) peptides.
US20180153504 3D ULTRASOUND IMAGING, ASSOCIATED METHODS, DEVICES, AND SYSTEMS  
Methods, system, and devices that are adapted to restrict the movement of an ultrasound transducer about at least one axis or point, and tag a plurality of frames of electronic signals indicative...
9988424 Immunogens comprising human immunodeficiency virus V1/V2 polypeptides  
The invention is generally directed to V1V2 immunogens.
9987358 Nanostars and nanoconstructs for detection, imaging, and therapy  
A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment...
9987309 Direct reprogramming of cells to cardiac myocyte fate  
A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA...
US20180149719 CIRCUITS FOR MAGNETIC RESONANCE IMAGING SYSTEMS FOR INTEGRATED PARALLEL RECEPTION, EXCITATION, AND SHIMMING  
Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (iPRES). Parallel transmit/receive (which can include B1 shimming and/or parallel imaging...
US20180148497 BISPECIFIC MOLECULES COMPRISING AN HIV-1 ENVELOPE TARGETING ARM  
The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods...
9982306 Somatic mutations in ATRX in brain cancer  
We determined the sequence of ATRX and DAXX in 447 cancers from various sites. We found mutations most commonly in pediatric glioblastoma multiformae (GBM) (11.1%), adult GBM (6.5%),...
US20180143276 MAGNETIC RESONANCE IMAGING (MRI) SYSTEMS AND METHODS USING ADIABATIC TIP-DOWN AND MATCHED ADIABATIC FLIP-BACK PULSES  
Magnetic resonance imaging (MRI) systems and methods using adiabatic tip-down and matched adiabatic flip-back pulses are disclosed. According to an aspect, a system includes a signal generator...
US20180142243 A METHOD OF REGULATING GENE EXPRESSION  
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.
US20180140720 COMPOSITIONS AND METHODS FOR TISSUE REGENERATION  
The present disclosure relates to compositions and methods for tissue regeneration.
9974848 Tetanus toxoid and CCL3 improve DC vaccines  
Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and efficacy of tumor antigen-specific DC...
US20180136296 RF COIL ELEMENTS WITH SPLIT DC LOOPS FOR MAGNETIC RESONANCE IMAGING SYSTEMS FOR INTEGRATED PARALLEL RECEPTION, EXCITATION, AND SHIMMING AND RELATED METHODS AND DEVICES  
Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (iPRES) with RF coil elements with split DC loops. Parallel transmit/receive (which can...
US20180133319 SYNERGISTIC NANOTHERAPY SYSTEMS AND METHODS OF USE THEREOF  
The presently disclosed subject matter is directed to a method of treating cancer, such as (but not limited to) metastatic bladder and breast cancer. The disclosed method comprises using two...
US20180133186 PREVENTATIVE TREATMENT OF ALZHEIMER'S DISEASE  
The present disclosure provides methods and formulations for the treatment of Alzheimer's disease in a subject in need thereof. The methods comprise administering to the subject an ornithine...
9971063 Broadband metamaterial apparatus, methods, systems, and computer readable media  
Broadband metamaterial apparatus, methods, systems, and computer readable media are disclosed, as well as exemplary embodiments that provide cloaking, beam steering, and beam focusing. In one...
9970897 Chemical sensors and methods for making and using the same  
A van der Pauw (VDP) sensor comprising an electronic circuit electrically coupled to a surface, the surface comprising a type III-V material, and the electronic circuit measuring a sheet...
9970014 Factor V/Va-targeting aptamer compositions and methods of using the same  
Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are...
US20180125869 BISPHOSPHONATE COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE  
The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate,...
9963501 B cell lineage based immunogen design with humanized animals  
Non-human animals with humanized immunoglobulin loci and methods of using them in vaccine design are described, as well as methods for making broadly neutralizing antibodies against infectious...
US20180120307 ACOUSTICALLY RESPONSIVE PARTICLES  
Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast...
US20180118743 COMPOSITION AND METHODS FOR THE TREATMENT OF CAMKK2-MEDIATED DISORDERS  
The present disclosure provides compositions and methods for treating ocular disorders in mammals especially in and not limited to humans and mice. The present disclosure further provides methods...
US20180117182 THROMBUS IMAGING APTAMERS AND METHODS OF USING SAME  
Provided herein are imaging agents, antidotes to the imaging agents and methods of using the same to image a thrombus or blood clot or thrombin including sites of thrombin accumulation and to...
US20180117111 Method Of Reducing Titers Of Antibodies Specific For A Therapeutic Agent  
The present invention relates, in general, to a method of treating patients undergoing enzyme replacement therapy (ERT) or other therapy involving the administration of a proteinaceous therapeutic...