Patents and Patent Applications from Duke University


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US20170357139 APPARATUS AND METHOD FOR PROVIDING A SELECTIVELY ABSORBING STRUCTURE  
An apparatus is described that selectively absorbs electromagnetic radiation. The apparatus includes a conducting surface, a dielectric layer formed on the conducting surface, and a plurality of...
US20170355992 FACTOR V/Va-TARGETING APTAMER COMPOSITONS AND METHODS OF USING THE SAME  
Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are...
9843189 Grid tied system controller including logic coupled to a photovoltaic station and an energy storage system  
A battery energy storage system control system, including: logic coupled to a photovoltaic station and an energy storage system and executing a photovoltaic station capacity firming algorithm...
9839704 Prosthetic compounds for labeling internalizing biomolecules  
Prosthetic compounds are disclosed that are effective for radiolabeling biomolecules with 18F. Representative biomolecules include antibodies (e.g., monoclonal antibodies (mAbs) and nanobodies...
US20170349544 Ethynylbenzene Derivatives  
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These...
US20170348531 NON-REGULAR ELECTRICAL STIMULATION PATTERNS FOR TREATING NEUROLOGICAL DISORDERS  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20170348214 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS  
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
9833634 Advanced methods and systems for treating cell proliferation disorders  
The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of...
US20170347460 Stretchable Electrically Conductive Layer Formation By Aerosol Jet Printing On Flexible Substrate  
Methods of forming an electrically conductive layer on a flexible substrate, such as a stretchable electrode, by aerosol jet printing on the flexible substrate while the substrate is strained. In...
US20170343603 MULTI-LAYER INTEGRATED CIRCUITS HAVING ISOLATION CELLS FOR LAYER TESTING AND RELATED METHODS  
Multi-layer integrated circuits having isolation cells for layer testing and related methods are disclosed. According to an aspect, an integrated circuit includes first and second layers that each...
9828582 Compositions and methods for the induction and tuning of gene expression  
Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.
US20170335299 RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY  
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
US20170333356 Treatment Method and Product for Uterine Fibroids using Purified Collagenase  
The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of...
US20170332939 Self-Gated Interleaved Radial MRI For Abdominothoracic Imaging  
The present disclosure provides, in part, methods for high spatiotemporal resolution self-sorted 4D MRI. These methods can be used to improve resolution of abdominothoracic MRI during breathing by...
9823127 Systems and methods for deep spectroscopic imaging of biological samples with use of an interferometer and spectrometer  
Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an...
9821053 Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins  
The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response...
9821036 Therapeutic agents comprising a GLP-2 peptide and elastin-like peptides  
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1...
9820655 Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo or a diffusion algorithm  
Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an...
US20170327866 METHODS FOR IN VIVO IDENTIFICATION OF ENDOGENOUS MRNA TARGETS OF MICRORNAS  
A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein...
US20170326258 CONTRAST AGENTS BASED ON LONG-LIVED NUCLEAR SINGLET STATES AND RELATED METHODS  
Methods are described for preparing magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having...
US20170326229 SWARM IMMUNIZATION WITH 54 ENVELOPES FROM CH505  
In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swami immunizations using combinations of HIV-1 envelopes.
US20170326199 USE OF CASPASE-2 INHIBITORS TO TREAT AND PREVENT THE METABOLIC SYNDROME  
Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and...
US20170326127 COMPOSITION AND METHOD FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERS  
The present invention relates to a composition and method for combinative therapy, capable of temporarily regulating inherent dysfunctional neural processes and reducing symptoms and/or signs of...
9815852 Macrocyclic compounds and methods of treatment  
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.
9814740 Methods and compositions combining immunotherapy with monocyte activation  
Methods of enhancing the effectiveness of an antibody-based therapeutic agent are provided herein. The methods include administering an antibody-based therapeutic and a composition capable of...
US20170322273 MAGNETIC RESONANCE IMAGING OF NEURO-ELECTRO-MAGNETIC OSCILLATIONS  
In vivo methods of non-invasively imaging neuro-electro-magnetic oscillations (NEMO) are carried out by electronically transmitting a pulse sequence to a subject. The pulse sequence has a first...
US20170322209 BIOSENSOR  
Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of...
US20170321280 NANO-PLASMONIC MOLECULAR PROBES FOR PLASMONICS COUPLING INTERFERENCE  
Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA,...
US20170319868 PHOSPHORS AND SCINTILLATORS FOR LIGHT STIMULATION WITHIN A MEDIUM  
A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and...
US20170319591 METHODS OF TREATING HEMOGLOBINOPATHIES  
Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the...
US20170312527 WAVEFORM SHAPES FOR TREATING NEUROLOGICAL DISORDERS OPTIMIZED FOR ENERGY EFFICIENCY  
Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of...
US20170312303 COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF  
In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
US20170311797 WHOLE EYE OPTICAL COHERENCE TOMOGRAPHY(OCT) IMAGING SYSTEMS AND RELATED METHODS  
Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm...
9802163 Electrically conducting reverse osmosis membranes  
The disclosure provides composite membranes for use in water purification and filtration.
9802046 Non-regular electrical stimulation patterns for improved efficiency in treating Parkinson's Disease  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20170307349 Non-Invasive Thickness Measurement Using Capacitance Measurement  
Methods of measuring thickness of a material using cross-capacitance. The method generally includes applying a time-varying signal to a first pad and monitoring a response of a capacitor formed by...
US20170306321 SYSTEMS AND METHODS FOR GENETIC ANALYSIS OF INTRACTABLE MICROBES  
Embodiments of the present disclosure relate generally to the genetic analysis of intractable microbes. More particularly, the present disclosure provides materials and methods that incorporate...
US20170304652 Systems and Methods for the Verification of Source Placement for Brachytherapy Radiation Procedures Using Real Time Radiation Detectors  
The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via...
US20170304488 Compositions and Methods for the Prevention and/or Reduction of Scarring  
The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.
US20170304162 COMPOSITIONS, SYSTEMS AND METHODS FOR THE ENCAPSULATION AND DELIVERY OF A SUBSTANCE  
A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple...
US20170303820 SYSTEMS, COMPOSITIONS AND DEVICES FOR IN VIVO MAGNETIC RESONANCE IMAGING OF LUNGS USING PERFLUORINATED GAS MIXTURES  
Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The...
9800059 Subscription based MISO and MIMO wireless energy transfer  
Subscription based multiple-input-single-output and multiple-input-multiple-output wireless energy transfer enables selective charging and powering of mobile devices using a plurality of spatially...
9797897 Acoustically responsive particles  
Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast...
9797703 Non-invasive thickness measurement using resonant frequency shift  
A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back...
US20170299784 NANOPATCH ANTENNAS AND RELATED METHODS FOR TAILORING THE PROPERTIES OF OPTICAL MATERIALS AND METASURFACES  
Nanopatch antennas and related methods for enhancing and tailoring are disclosed. According to an aspect, an apparatus includes a conductive material defining a substantially planar surface. The...
US20170299655 SIGNAL TRACING USING ON-CHIP MEMORY FOR IN-SYSTEM POST-FABRICATION DEBUG  
A post-fabrication debug and on-line error checking framework for 2D- and 3D-ICs with integrated memories is described. A design-for-debug (DfD) architecture can include, for an IC with on-chip...
US20170298331 GENETIC CORRECTION OF MUTATED GENES  
Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
9789154 Plasmonics-active metal nanostar compositions and methods of use  
Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the...
US20170294248 NOBLE METAL-COATED NANOSTRUCTURES AND RELATED METHODS  
Noble metal-coated nanostructures and related methods are disclosed. According to an aspect, a nanostructure may include a structure comprising a base metal. As an example, the structure may be a...
US20170290650 IMPLANTABLE MESH AND METHOD OF USE  
An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the...