Patents and Patent Applications from Duke University


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US20170299784 NANOPATCH ANTENNAS AND RELATED METHODS FOR TAILORING THE PROPERTIES OF OPTICAL MATERIALS AND METASURFACES  
Nanopatch antennas and related methods for enhancing and tailoring are disclosed. According to an aspect, an apparatus includes a conductive material defining a substantially planar surface. The...
US20170299655 SIGNAL TRACING USING ON-CHIP MEMORY FOR IN-SYSTEM POST-FABRICATION DEBUG  
A post-fabrication debug and on-line error checking framework for 2D- and 3D-ICs with integrated memories is described. A design-for-debug (DfD) architecture can include, for an IC with on-chip...
US20170298331 GENETIC CORRECTION OF MUTATED GENES  
Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
9789154 Plasmonics-active metal nanostar compositions and methods of use  
Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the...
US20170294248 NOBLE METAL-COATED NANOSTRUCTURES AND RELATED METHODS  
Noble metal-coated nanostructures and related methods are disclosed. According to an aspect, a nanostructure may include a structure comprising a base metal. As an example, the structure may be a...
US20170290650 IMPLANTABLE MESH AND METHOD OF USE  
An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the...
9782475 Method of treating food allergies by administering a nanoparticle comprising heparin and chitosan encapsulating IL-12  
Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2,...
US20170283882 METHODS AND THERAPEUTICS RELATING TO MRNA BIOMARKERS FOR CLINICAL PROGNOSIS OF CANCER  
This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mRNA or downstream expression products thereof. The...
US20170283872 COMPOSITIONS AND METHODS FOR ENHANCING ODORANT RECEPTOR ACTIVITY  
The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine...
US20170282214 METHODS AND SYSTEMS FOR DEPOSITION OF BLENDED POLYMER FILMS  
Methods and systems for deposition of blended polymer films are disclosed. According to an aspect a method of producing a film on a substrate includes combining a guest material, a host matrix,...
US20170281749 COMPOSITIONS COMPRISING CH505 ENVELOPES, AND TRIMERS  
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain...
US20170274037 PEPTIDES FOR SUPPRESSING INFLAMMATION  
Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods...
9771620 Biomarkers of high-grade serous ovarian carcinomas  
The present disclosure provides biomarkers useful for determining the prognosis of conditions such as ovarian cancer. The presently disclosed subject matter provides angiogenic biomarkers and...
9771396 Phase transition biopolymers and methods of use  
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be...
US20170267651 TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH  
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof....
9768516 Metamaterials for surfaces and waveguides  
Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may...
9764026 Compositions, methods, and kits for eliciting an immune response  
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing...
US20170260191 KINASE INHIBITORS AND RELATED METHODS OF USE  
The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating...
US20170259067 Non-Regular Electrical Stimulation Patterns Designed with a Cost Function for Treating Neurological Disorders  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
9762813 Monocentric lens-based multi-scale optical systems and methods of use  
A monocentric lens-based multi-scale imaging system is disclosed. Embodiments of the present invention comprise a monocentric lens as an objective lens that collects light from a scene....
9760979 Navigator-less segmented diffusion weighted imaging enabled by multiplexed sensitivity-encoded imaging with inherent phase correction  
Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) using a new technique, termed multiplexed sensitivity encoding with inherent phase correction, is proposed and implemented to...
US20170254999 MULTISCALE TELESCOPIC IMAGING SYSTEM  
A multiscale telescopic imaging system is disclosed. The system includes an objective lens, having a wide field of view, which forms an intermediate image of a scene at a substantially spherical...
US20170254634 Non-Invasive Thickness Measurement Using Resonant Frequency Shift  
A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back...
9754202 Low power radio frequency communication  
A method, system and tag for low power radio frequency communication is described. In one embodiment, the RF tag comprises: an access point coupled to provide access to a network; an RF tag...
9754139 Real-time wireless power transfer control for passive backscattering devices  
A method and apparatus is disclosed herein for real-time wireless power transfer control. In one embodiment, a system comprises: an RF-energy harvesting sensor tag operable to generate a first...
US20170250805 Reconfigurable Free-Space Quantum Cryptography System  
A system, and methods, for transmitting encrypted information as a quantum transmission between a first node and a second node, or among more than two nodes. Each node is characterized by an...
US20170247765 METHODS FOR RAPID AND SENSITIVE DETECTION OF HOTSPOT MUTATIONS  
Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and...
9747538 Low power radio frequency communication  
A method, system and tag for low power radio frequency communication is described. In one embodiment, the RF tag comprises: an energy harvesting unit operable to convert incident RF energy to...
9744363 Non-regular electrical stimulation patterns for treating neurological disorders  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
9744138 Treatment method and product for uterine fibroids using purified collagenase  
The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of...
US20170239363 POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME  
Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer...
US20170239352 COMBINATION DRUG THERAPY FOR THE TREATMENT OF SOLID TUMORS  
The present invention relates to a pharmaceutical combination that comprises an IGF1R inhibitor and an mTOR inhibitor for the treatment of cancer in a subject; a pharmaceutical composition...
US20170239160 COSMETIC AND PHARMACEUTICAL COMPOSITIONS AND METHODS USING 2-DECARBOXY-2-PHOSPHINICO DERIVATIVES  
A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions...
9738879 Genetic correction of mutated genes  
Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
9738643 Substituted indazoles for targeting Hsp90  
Described herein are substituted indazoles that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such...
9738604 Ethynylbenzene derivatives  
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These...
US20170233714 POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME  
Disclosed herein are compositions and methods for reducing the antigenicity of molecules, wherein the molecule comprises a uricase. The antigenicity of a molecule may be reduced or eliminated by...
9730921 Compositions and methods for the prevention and treatment of mast cell-induced vascular leakage  
Disclosed herein are methods of diagnosing and treating infectious disease characterized by a pathology that involves hemorrhaging or pathological vascular leakage.
US20170227553 COMPOSITIONS AND METHODS FOR IDENTIFYING AND TREATING CONDITIONS INVOLVING HSF1 ACTIVITY  
Provided herein are methods for identifying and treating subjects having conditions involving reduced HSF1 activity (e.g., diminished HSF1 activity, diminished HSF1 protein levels, increased HSF1...
US20170224712 PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE  
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The...
9730029 Unsupervised indoor localization and heading directions estimation  
Systems and methods for unsupervised indoor localization are provided. Sensor data obtained from a device carried by a user can be used to simultaneously estimate the indoor location of a user and...
9724015 Systems, methods, compositions and devices for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures  
Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The...
US20170216808 PROGRAMMABLE LIQUID, GEL AND BIOHYBRID COMPARTMENTS AND METHODS OF USE  
Nano- to microscale liquid coacervate particles are provided. The liquid coacervate particles are produced by a process including stimulating a population of liquid droplets containing one or a...
US20170216426 COMPOSITIONS AND METHODS FOR TRANSIENT IMMUNE RESPONSE MODULATION DURING VACCINATION  
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain...
US20170216382 Oncolytic Poliovirus for Human Tumors  
Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune...
US20170216289 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER  
The present disclosure provides compositions and methods for the treatment of cancer, relating to the specific inhibition of Abelson (ABL) kinases.
9720036 Signal tracing using on-chip memory for in-system post-fabrication debug  
A post-fabrication debug and on-line error checking framework for 2D- and 3D-ICs with integrated memories is described. A design-for-debug (DfD) architecture can include, for an IC with on-chip...
9718873 Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin  
The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides...
9718784 Substituted pyrazoles as heat shock transcription factor activators  
The present invention relates to substituted pyrazole compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates,...
9717789 Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies  
The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a method of inducing neutralizing antibodies to HIV and to compounds and compositions...