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US20120030783 |
RATIONALLY DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
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US20120028369 |
QUANTIFYING LOCAL INFLAMMATORY ACTIVITY AND ITS USE TO PREDICT DISEASE PROGRESSION AND TAILOR TREATMENTS
This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting the...
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8105781 |
Predictors of long-term mortality following coronary artery bypass graft surgery
The present invention relates, in general, to perioperative depression and, in particular, to methods of identifying individuals at risk of perioperative depression.
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US20120018306 |
Sample Processing Droplet Actuator, System and Method
Sample processing droplet actuators, systems and methods are provided. According to one embodiment, a stamping device including a droplet microactuator is provided and includes: (a) a first plate...
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US20120015366 |
METHODS AND COMPOSITIONS TO IDENTIFY INCREASED RISK OF BREAST CANCER BY DETECTION OF CPG ISLAND METHYLATOR PHENOTYPE (CIMP)
The present invention is directed to kits and methods for identifying a female subject as having an increased risk of developing breast cancer, comprising detecting a CPG island methylator...
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US20120014507 |
Automatic Generation of Patient-Specific Radiation Therapy Planning Parameters
An apparatus and method for automatically generating radiation treatment planning parameters are disclosed. In accordance with the illustrative embodiment, a database is constructed that stores:...
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8097415 |
Methods for identifying an individual at increased risk of developing coronary artery disease
The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more...
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US20120003225 |
AUTOANTIBODIES IN THE DETECTION AND TREATMENT OF CANCER
Methods, kits, and compositions for detecting and/or treating cancer based on detecting and/or administering an antibody, which can optionally be a bispecific antibody, having the immunoreaction...
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8088587 |
Genetic variants increase the risk of age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as...
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US20110318360 |
ANTI-LIPID ANTIBODIES
The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-I infection using anti-lipid (e.g. anti-phospholipid) antibodies.
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8086297 |
Dark blood delayed enhancement magnetic resonance viability imaging techniques for assessing subendocardial infarcts
The technology herein provides a dark blood delayed enhancement technique that improves the visualization of subendocardial infarcts that may otherwise be disguised by the bright blood pool. The...
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US20110312947 |
Method of improving ß-adrenergic receptor function
The present invention relates to a method of increasing the sensitivity of a hyperinsulinemic patient to the anti-obesity and antidiabetic effects of a β adrenergic receptor (βAR) agonist. The m...
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US20110311986 |
CELL LINES COMPRISING SOUR-TASTE RECEPTORS
The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for...
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US20110311181 |
Optical Isolator
Various optical isolator embodiments are disclosed. Embodiments comprise a waveguide section utilizing materials that induce a propagation constant shift that is propagation-direction-dependent....
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8081364 |
High-speed multi-dimensional beam scanning system with angle amplification
A beam-steering system having high positional resolution and fast switching speed is disclosed. Embodiments of the beam-steering system comprise a diffraction limited optical system that includes a...
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US20110305700 |
Anti-lipid antibodies
The present invention relates, in general, to anti-lipid antibodies and, in particular, to methods of inhibiting HIV-1 infection using anti-lipid (e.g. antiphospholipid) antibodies.
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8077325 |
Methods, systems and computer program products for characterizing structures based on interferometric phase data
Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an...
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8076059 |
Adjuvant capable of specifically activating the adaptive immune response
A composition for eliciting an immune response to an immunogen comprises an immunogen in combination with a mast cell membrane activator such as compound 48/80. Any suitable immunogen may be...
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8075922 |
Method of co-infusing a deoxygenated hemoglobin containing blood substitute and inorganic nitrite
Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce...
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8074661 |
Method and apparatus for laser tissue ablation
A method and apparatus for ablating material. The material is preferably a heterogenous or composite material, such as animal tissue. A table top laser system can be employed in the invention....
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US20110301328 |
POLYVALENT VACCINE
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
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US20110299147 |
High-Speed Multi-Dimensional Beam Scanning System With Angle Amplification
A beam-steering system having high positional resolution and fast switching speed is disclosed. Embodiments of the beam-steering system comprise a diffraction limited optical system that includes a...
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8071107 |
Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an...
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US20110294680 |
METHODS AND COMPOSITIONS FOR PREDICTING SUCCESS IN ADDICTIVE SUBSTANCE CESSATION AND FOR PREDICTING A RISK OF ADDICTION
The present invention relates to genetic polymorphisms that are associated with dependence on an addictive substance. In particular, the present invention relates to a method for predicting success...
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US20110294189 |
BIOMOLECULE POLYMER CONJUGATES AND METHODS FOR MAKING THE SAME
Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from...
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8067553 |
PEG-urate oxidase conjugates and use thereof
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of...
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US20110288149 |
Method of protecting against heart failure
The present invention relates, in general, to heart failure, and, in particular to a method of reducing the risk of heart failure, particularly in patents with established cardiomyopathy.
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US20110287466 |
Aggregate-Free Urate Oxidase for Preparation of Non-Immunogenic Polymer Conjugates
A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by...
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US20110275928 |
BLOOD SIGNAL SUPPRESSED ENHANCED MAGNETIC RESONANCE IMAGING
Methods for achieving suppression of blood pool signal to image contrast-enhanced organs and vascular walls using magnetic resonance (MR) imaging technology. After administration of e.g., an...
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US20110275606 |
SUBSTITUTED PORPHYRINS
Discloses are compounds according to Formula I. Further provided are methods of reducing oxidative stress in a cell, methods of treating a disease including cancer, and methods of treating a...
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US20110275146 |
FUSION PROTEINS COMPRISING DP-178 AND OTHER VIRAL FUSION INHIBITOR PEPTIDES USEFUL FOR TREATING AIDS
The present invention relates to fusion peptides which exhibit potent anti-retroviral activity. The fusion peptides of the invention comprise a macromolecular carrier group fused to a gp41-derived...
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8048628 |
Methods for nucleic acid amplification on a printed circuit board
Methods for amplifying nucleic acid, such as DNA or RNA, on a printed circuit board (PCB) substrate are disclosed. The amplification can be achieved through a variety of methods such as...
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8048431 |
Modified HIV-1 clade C envelope glycoprotein immunogens comprising deletions in the gp120/gp41 cleavage site and gp41 fusion domain
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen...
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8048415 |
Compositions and methods for promoting or inhibiting angiogenesis
Compounds, compositions and methods for promoting or inhibiting angiogenesis, and screening methods for identifying compounds are disclosed. The compounds bind to F1 ATP synthase, particularly to...
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US20110263920 |
ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS
The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of...
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8041463 |
Modular droplet actuator drive
A droplet actuator drive including a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the...
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8039593 |
Antibodies and immunotoxins that target human glycoprotein NMB
The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells,...
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8039217 |
Proteomic interaction and genomic action determinations in the presence of associated redox state conditions
Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are...
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8034783 |
Prodomain modulators of ADAM 10
The presently disclosed subject matter discloses isolated ADAM 10 modulating peptides and related compounds useful for studying the biological functions of ADAM 10 and for the treatment of diseases...
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US20110242543 |
INTERFEROMETRIC SYSTEMS HAVING REFLECTIVE CHAMBERS AND RELATED METHODS
Disclosed herein are interferometric systems having reflective chambers and related methods. According to an aspect, an interferometric system may include a light source for generating an...
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US20110236393 |
MONOCLONAL ANTIBODY PRODUCTION IN B CELLS AND USES THEROF
The presently disclosed subject matter provides methods of inhibiting a host innate response to activator-mediated proliferative signals in a primary B cell. In some embodiments a method is...
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US20110236384 |
DIRECT DRUG DELIVERY SYSTEM BASED ON THERMALLY RESPONSIVE BIOPOLYMERS
A method for delivering a drug depot of a compound of interest to a selected region in a subject. The method comprises administering a composition directly to said region of interest, the...
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US20110236371 |
Compositions And Methods For The Treatment Of Neurologic And Psychiatric Conditions
The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides...
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US20110236345 |
COMPOSITION AND METHODS FOR ELICITING AN IMMUNE RESPONSE
The present invention relates to compositions, methods, and kits for eliciting an immune response, in particular for eliciting an immune response to at least one antigen expressed by a cancer cell,...
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US20110230540 |
MANASSATIN COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further...
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US20110229479 |
GENETIC ALTERATIONS IN ISOCITRATE DEHYDROGENASE AND OTHER GENES IN MALIGNANT GLIOMA
We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from...
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8021867 |
Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate...
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8017316 |
Methods and compositions for the identification of insect repellent compounds
Methods for identifying a candidate compound with an ability to modulate cation transport through a transient receptor potential (TRP) channel in a cell are disclosed. The methods can include (a)...
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US20110217231 |
ANTI-TENASCIN MONOCLONAL ANTIBODY THERAPY FOR LYMPHOMA
A method of treating lymphoma in a subject comprises administering to a subject afflicted with lymphoma an antibody that binds to tenascin in a therapeutically effective amount. Preferably the...
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US20110211106 |
Monocentric Lens-based Multi-scale Optical Systems and Methods of Use
A monocentric lens-based multi-scale imaging system is disclosed. Embodiments of the present invention comprise a monocentric lens as an objective lens that collects light from a scene. Monocentric...
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