Patents and Patent Applications from Duke University


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9939450 Quantifying local inflammatory activity and its use to predict disease progression and tailor treatments  
This invention relates to a method of predicting progression of an inflammatory condition in a subject, which involves providing a medium comprising hyaluronan or a fragment thereof; contacting...
9937178 Methods of identifying and using MDM2 inhibitors  
Methods of treating subjects with cancer and screening for MDM2 inhibitors that may be effective cancer therapeutics are provided herein. The cancers that may be treated using MDM2 inhibitors...
9936868 Systems and methods for obtaining low-angle circumferential optical access to the eye  
A system for obtaining low-angle circumferential optical access to an eye of a subject. The system includes a light source to generate a beam of light; a beam steering mechanism to steer the beam...
US20180095129 SOFTWARE-BASED SELF-TEST AND DIAGNOSIS USING ON-CHIP MEMORY  
Embedded processor-based self-test and diagnosis using the compressed test data is described for ICs having on-chip memory. Techniques for compressing the test data before the compressed test data...
US20180095128 SOFTWARE-BASED SELF-TEST AND DIAGNOSIS USING ON-CHIP MEMORY  
Embedded processor-based self-test and diagnosis using the compressed test data is described for ICs having on-chip memory. Techniques for compressing the test data before the compressed test data...
US20180094238 COMPOSITIONS AND METHODS FOR THE INDUCTION AND TUNING OF GENE EXPRESSION  
Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.
US20180094050 VACCINES AGAINST HER3 ANTIGENS AND METHODS OF USING THE SAME  
The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to antigenic polypeptides and their use in cancer vaccines...
US20180092989 MITOCHONDRIAL ANTIVIRAL SIGNALING (MAVS) PROTEIN COMPOSITIONS AND METHODS OF USING THE SAME  
The invention generally relates to compositions and methods for preventing and treating cancer. More specifically, the invention relates to MAVS compositions and their use in cancer therapeutics...
9931402 Compositions for the treatment of solid tumors  
The present invention relates to a pharmaceutical combination that comprises an IGF1R inhibitor and an mTOR inhibitor for the treatment of cancer in a subject; a pharmaceutical composition...
9931342 Compositions and methods for the treatment of cancer  
The present disclosure provides compositions and methods for the treatment of cancer, relating to the specific inhibition of Abelson (ABL) kinases.
9927440 Protein engineering  
Methods of optimizing mRNA sequences for expression in host cells are provided. Methods of determining the stability of a protein are also provided. Methods of determining the affinity of a ligand...
US20180079801 HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (CD4bs ANTIBODIES)  
The invention relates to the identification of monoclonal HIV-1 neutralizing antibodies, such as, but not limited to, antibodies that bind to the CD4 binding site (CD4bs) of HIV-1 gp120, their...
US20180073003 Method of Treating Glycogen Storage Disease  
The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease and to compounds and compositions suitable for use in such a...
US20180072797 HIV-1 NEUTRALIZING ANTIBODIES AND USES THEREOF (V3 ANTIBODIES)  
The invention is directed to HIV-1 neutralizing antibodies, CD4 binding site and V3 glycan antibodies, and methods for their uses.
US20180071410 Contrast Agents for Magnetic Resonance Imaging  
Ascorbate or a pharmaceutically acceptable salt thereof is described for use in carrying out a method, or for the preparation of a medicament for carrying out a method, of enhancing a magnetic...
9913863 Regulatory B cells and their uses  
The present invention relates to a phenotypically distinct CD1dhighCD5+ B cell subset that regulates T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-10). The...
US20180069318 METAMATERIALS FOR SURFACES AND WAVEGUIDES  
Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may...
US20180067137 COMPOSITIONS AND METHODS FOR METABOLIC PROFILING IN SUBJECTS WITH HEART FAILURE WITH PRESERVED EJECTION FRACTION  
Disclosed herein are compositions and methods for targeted metabolomics profiling to provide absolute quantification of a broad array of metabolic intermediates of fatty acids, amino acids, and...
US20180067129 Compositions and Methods for Identifying and Modulating Metabolic Health  
This invention provides reagents, methods and biochemical markers for identifying and providing therapeutic intervention for individuals with metabolic dysfunction, or individuals at risk for...
US20180064944 NON-REGULAR ELECTRICAL STIMULATION PATTERNS FOR IMPROVED EFFICIENCY IN TREATING PARKINSON'S DISEASE  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20180064943 SYSTEMS AND METHODS FOR SPINAL CORD STIMULATION  
Delivering stimulation includes delivering temporal patterns of stimulation pulses to respective transducers of an array of transducers, wherein the delivery of the pattern to a particular...
9908938 Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor and an antigen expressed by a cell infected by a virus and uses thereof  
The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby...
9908851 2-piperidinyl substituted N,3-dihydroxybutanamides  
Disclosed are compounds of formulae: (I) and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, Y, and Z are defined herein. These compounds are useful for treating...
9907976 Phosphors and scintillators for light stimulation within a medium  
A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and...
9907839 Treatment of glycogen storage disease type II  
Methods of treating glycogen storage disease type II, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II.
9901568 Pharmaceutical compositions of 5-hydroxytryptophan and serotonin-enhancing compound  
This invention relates to novel pharmaceutical compositions comprising a therapeutically effective amount of a slow-release formulation of 5-hydroxytryptophan (5-HTP) and a serotonin-enhancing...
9901560 Methods and compositions for treatment of acute lung injury  
A method of treating acute lung injury (ALI) in a patient suspected of having ALI is disclosed. The method includes administering to the patient a therapeutically effective amount of an inducible...
9901553 Method of modulating the activity of a nucleic acid molecule  
The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic...
US20180050077 PLASMONICS-ACTIVE METAL NANOSTAR COMPOSITIONS AND METHODS OF USE  
Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the...
US20180045846 ELECTROMAGNETIC (EM) WELL LOGGING TOOLS AND RELATED METHODS  
An electromagnetic well logging tool for a wireline logging process, includes a shaft, a transmitter coil mounted on the shaft and configured to generate primary magnetic fields for propagation...
US20180044736 BIOMARKER BASED PROGNOSTIC MODEL FOR PREDICTING OVERALL SURVIVAL IN PATIENTS WITH METASTATIC CLEAR CELL KIDNEY CANCER  
The present invention describes a method of using a molecular prognostic signature, to predict overall survival in patients with metastatic clear cell renal cell carcinoma. The present invention...
US20180043184 AUTOMATIC DETERMINATION OF RADIATION BEAM CONFIGURATIONS FOR PATIENT-SPECIFIC RADIATION THERAPY PLANNING  
Systems and methods for efficient and automatic determination of radiation beam configurations for patient-specific radiation therapy planning are disclosed. According to an aspect, a method...
US20180043182 SYSTEMS AND METHODS FOR AUTOMATED RADIATION TREATMENT PLANNING WITH DECISION SUPPORT  
Systems and methods for automated radiation treatment planning with decision support are disclosed. According to an aspect, a method includes receiving data based on patient information and...
US20180042969 COMPOSITIONS AND METHODS FOR THE REPROGRAMMING OF CELLS INTO CARDIOMYOCYTES  
The present disclosure provides compositions and methods for the reprogramming of cells such as fibroblasts into cardiomyocytes. The invention provided herein features a chemically defined media...
9890420 Non-fouling polymeric surface modification and signal amplification method for biomolecular detection  
An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a...
US20180037928 GLUCOSE/GALACTOSE BIOSENSORS AND METHODS OF USING SAME  
Provided herein are glucose and galactose biosensors and methods of making and using the same.
US20180037609 PHASE TRANSITION BIOPOLYMERS AND METHODS OF USE  
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be...
US20180036408 ADVANCED METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS  
The present invention relates to methods for treating cell proliferation disorders comprising: (1) administering to the subject at least one activatable pharmaceutical agent that is capable of...
US20180036400 DOUBLE ENGINEERED HIV-1 ENVELOPES  
In certain aspects the invention provides HIV-1 engineered envelope proteins and their uses. The engineered envelopes comprise a sequence that prevents cleavage of the envelope associated with...
9888038 Method and apparatus for providing mobile and social services via virtual individual servers  
A method, computer readable medium and apparatus for providing a virtual individual server service within a communications network are disclosed. For example, the method receives a request from a...
9886745 Multi-shot scan protocols for high-resolution MRI incorporating multiplexed sensitivity-encoding (MUSE)  
Multi-shot DWI with multiplexed sensitivity-encoding (MUSE) inherently corrects nonlinear shot-to-shot phase variations without requiring the use of navigator echoes. The multi-shot DWI can use...
9885024 PEG-urate oxidase conjugates and use thereof  
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of...
9884166 Jetless intravenous catheters and mechanical assist devices for hand-injection of contrast media during dynamic tomography and methods of use  
A jetless intravenous catheter for the delivery of a fluid into a peripheral vein of a subject includes an elongated body having proximal and distal ends. The body includes a wall defining an...
9883852 Ultrasound systems, methods and computer program products for estimating tissue deformation with harmonic signals  
An ultrasound system for estimating tissue deformation in ultrasound elasticity imaging includes a controller configured to deliver a plurality of tracking pulses and to obtain a plurality of data...
US20180031354 ELECTROMAGNETIC CLOAKING METHOD  
A method of constructing a concealing volume comprises constructing a plurality of concealing volume elements around a concealable volume. Each concealing volume element has a material parameter...
9880242 RF coil elements with split DC loops for magnetic resonance imaging systems for integrated parallel reception, excitation, and shimming and related methods and devices  
Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (iPRES) with RF coil elements with split DC loops. Parallel transmit/receive (which can...
9879005 Composition and methods for the treatment of CaMKK2-mediated disorders  
The present disclosure provides compositions and methods for treating ocular disorders in mammals especially in and not limited to humans and mice. The present disclosure further provides methods...
9877908 Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives  
A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions...
US20180023065 FUSION MOLECULES OF RATIONALLY-DESIGNED DNA-BINDING PROTEINS AND EFFECTOR DOMAINS  
Targeted transcriptional effectors (transcription activators and transcription repressors) derived from meganucleases are described. Also described are nucleic acids encoding same, and methods of...
US20180023064 COMPOSITIONS AND METHODS FOR EPIGENOME EDITING  
Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said...