Patents and Patent Applications from Duke University


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9868707 Small molecule agonists of neurotensin receptor 1  
Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
9868705 Tetra-aryl cyclobutane inhibitors of androgen receptor action for the treatment of hormone refractory cancer  
The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.
9867838 Methods for treating heart failure using bisphosphonate compositions  
The present invention provides for methods for treating and/or reducing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue...
US20180008718 COMPOSITIONS FOR THE SUSTAINED RELEASE OF ANTI-GLAUCOMA AGENTS TO CONTROL INTRAOCULAR PRESSURE  
Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the...
US20180008147 SYSTEMS AND METHODS FOR ENDOSCOPIC ANGLE-RESOLVED LOW COHERENCE INTERFEROMETRY  
A method of assessing tissue health comprises the steps of obtaining depth-resolved spectra of a selected area of in vivo tissue, and assessing the health of the selected area based on the...
US20180008140 STEREOSCOPIC DISPLAY SYSTEMS AND METHODS FOR DISPLAYING SURGICAL DATA AND INFORMATION IN A SURGICAL MICROSCOPE  
Stereoscopic display systems and methods for displaying surgical data and information in a surgical microscope are disclosed herein. According to an aspect, a system includes first and second...
9864183 Systems and methods for structured illumination super-resolution phase microscopy  
Systems and methods for structured illumination super-resolution phase microscopy are disclosed. According to an aspect, an imaging system includes a light source configured to generate light. The...
9864174 System comprising a spectrally selective detector  
Optical systems based on an objective lens comprising one or more plastic lens elements are disclosed. The inclusion of plastic lens element reduces one or more of system cost, size, weight,...
9864025 Magnetic resonance imaging systems for parallel transmit, receive and shim and methods of use thereof  
MRI systems with a new concept and hardware modality configured for parallel transmit, receive, and shim to address B0 and B1 inhomogeneity, both of which increase with field strength. This...
9864007 Software-based self-test and diagnosis using on-chip memory  
Embedded processor-based self-test and diagnosis using the compressed test data is described for ICs having on-chip memory. Techniques for compressing the test data before the compressed test data...
9861685 Methods of treating hemoglobinopathies  
Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the...
9861625 Methods and compositions for treating cancer through inhibition of PI3K  
Provided herein are methods for treating cancer relating to inhibition of PI3K, as pharmaceutical compositions comprising a PI3K inhibitor and a PAK1 inhibitor.
9861574 2-fluoro-modified RNAs as immunostimulators  
Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine...
US20180001472 SPECIALIZED ROBOT MOTION PLANNING HARDWARE AND METHODS OF MAKING AND USING SAME  
Specialized robot motion planning hardware and methods of making and using same are provided. A robot-specific hardware can be designed using a tool that receives a robot description comprising a...
9858531 Fault tolerant scalable modular quantum computer architecture with an enhanced control of multi-mode couplings between trapped ion qubits  
A modular quantum computer architecture is developed with a hierarchy of interactions that can scale to very large numbers of qubits. Local entangling quantum gates between qubit memories within a...
9856476 Method of regulating gene expression  
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.
9855329 Mosaic HIV envelope immunogenic polypeptides  
Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are...
US20170369491 COMPOUNDS AND METHODS FOR TARGETING HSP90  
Described herein are compounds that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds may include detection moieties such as...
US20170368050 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF MAST CELL-INDUCED VASCULAR LEAKAGE  
Disclosed herein are methods of diagnosing and treating infectious disease characterized by a pathology that involves hemorrhaging or pathological vascular leakage.
9850539 Biomarkers for the molecular classification of bacterial infection  
Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
9850485 Method of regulating gene expression  
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.
9850474 Methods for treating glycogen storage disease type IV usng lysosomal acid alpha-glucosidase  
The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease and to compounds and compositions suitable for use in such a...
US20170360946 ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES  
Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ...
9845481 Synthetic regulation of gene expression  
Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a...
9844590 Mosaic clade M human immunodeficiency virus type 1 (HIV-1) gag immunogens  
The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to...
9844589 Modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins capable of inducing broadly reactive T- and B-cell responses  
The invention relates to HIV-1 envelope polypeptides comprising the consensus envelope of SEQ ID NO: 35, compositions comprising these envelopes and methods for using same.
US20170357139 APPARATUS AND METHOD FOR PROVIDING A SELECTIVELY ABSORBING STRUCTURE  
An apparatus is described that selectively absorbs electromagnetic radiation. The apparatus includes a conducting surface, a dielectric layer formed on the conducting surface, and a plurality of...
US20170355992 FACTOR V/Va-TARGETING APTAMER COMPOSITONS AND METHODS OF USING THE SAME  
Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are...
9843189 Grid tied system controller including logic coupled to a photovoltaic station and an energy storage system  
A battery energy storage system control system, including: logic coupled to a photovoltaic station and an energy storage system and executing a photovoltaic station capacity firming algorithm...
9839704 Prosthetic compounds for labeling internalizing biomolecules  
Prosthetic compounds are disclosed that are effective for radiolabeling biomolecules with 18F. Representative biomolecules include antibodies (e.g., monoclonal antibodies (mAbs) and nanobodies...
US20170349544 Ethynylbenzene Derivatives  
Disclosed are compounds of formulae (I), (II), and (II)I: and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R101, L, D, Q, Y, X, and Z are defined herein. These...
US20170348531 NON-REGULAR ELECTRICAL STIMULATION PATTERNS FOR TREATING NEUROLOGICAL DISORDERS  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20170348214 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS  
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
9833634 Advanced methods and systems for treating cell proliferation disorders  
The present invention relates to methods for treating cell proliferation disorders comprising (1) administering to the subject at least one activatable pharmaceutical agent that is capable of...
US20170347460 Stretchable Electrically Conductive Layer Formation By Aerosol Jet Printing On Flexible Substrate  
Methods of forming an electrically conductive layer on a flexible substrate, such as a stretchable electrode, by aerosol jet printing on the flexible substrate while the substrate is strained. In...
US20170343603 MULTI-LAYER INTEGRATED CIRCUITS HAVING ISOLATION CELLS FOR LAYER TESTING AND RELATED METHODS  
Multi-layer integrated circuits having isolation cells for layer testing and related methods are disclosed. According to an aspect, an integrated circuit includes first and second layers that each...
9828582 Compositions and methods for the induction and tuning of gene expression  
Disclosed herein are compositions of transcription activator-like effectors transcription factors and methods of using said compositions for inducing gene expression of mammalian genes.
US20170335299 RATIONALLY-DESIGNED MEGANUCLEASES WITH ALTERED SEQUENCE SPECIFICITY AND DNA-BINDING AFFINITY  
Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and...
US20170333356 Treatment Method and Product for Uterine Fibroids using Purified Collagenase  
The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of...
US20170332939 Self-Gated Interleaved Radial MRI For Abdominothoracic Imaging  
The present disclosure provides, in part, methods for high spatiotemporal resolution self-sorted 4D MRI. These methods can be used to improve resolution of abdominothoracic MRI during breathing by...
9823127 Systems and methods for deep spectroscopic imaging of biological samples with use of an interferometer and spectrometer  
Disclosed herein are systems and methods for deep spectroscopic imaging of a biological sample. In an aspect, a system includes a broad bandwidth light source configured to generate an...
9821053 Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins  
The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response...
9821036 Therapeutic agents comprising a GLP-2 peptide and elastin-like peptides  
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1...
9820655 Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo or a diffusion algorithm  
Systems and methods for spectral analysis of a tissue mass using an instrument, an optical probe, and a Monte Carlo algorithm or a diffusion algorithm are provided. According to one method, an...
US20170327866 METHODS FOR IN VIVO IDENTIFICATION OF ENDOGENOUS MRNA TARGETS OF MICRORNAS  
A method of generating a gene expression profile of noncoding regulatory RNA (ncRNA; e.g. a microRNA) in a cell in vivo, is carried out by: (a) partitioning from a cell at least one mRNA-protein...
US20170326258 CONTRAST AGENTS BASED ON LONG-LIVED NUCLEAR SINGLET STATES AND RELATED METHODS  
Methods are described for preparing magnetic resonance imaging (MRI) and/or magnetic resonance spectroscopy contrast agents where the contrast agents are prepared from precursor molecules having...
US20170326229 SWARM IMMUNIZATION WITH 54 ENVELOPES FROM CH505  
In certain aspects the invention provides HIV-1 immunogens, including envelopes (CH505) and selections therefrom, and methods for swami immunizations using combinations of HIV-1 envelopes.
US20170326199 USE OF CASPASE-2 INHIBITORS TO TREAT AND PREVENT THE METABOLIC SYNDROME  
Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and...
US20170326127 COMPOSITION AND METHOD FOR TREATMENT OF NEUROPSYCHIATRIC DISORDERS  
The present invention relates to a composition and method for combinative therapy, capable of temporarily regulating inherent dysfunctional neural processes and reducing symptoms and/or signs of...
9815852 Macrocyclic compounds and methods of treatment  
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.