Patents and Patent Applications from Duke University


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US20170322209 BIOSENSOR  
Biosensors are made by attaching covalently or non-covalently at least one reporter group to one or more specific positions of a bacterial periplasmic binding protein (bPBP). Upon binding of...
US20170321280 NANO-PLASMONIC MOLECULAR PROBES FOR PLASMONICS COUPLING INTERFERENCE  
Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA,...
US20170319868 PHOSPHORS AND SCINTILLATORS FOR LIGHT STIMULATION WITHIN A MEDIUM  
A system and method for light stimulation within a medium. The system has a reduced-voltage x-ray source configured to generate x-rays from a peak applied cathode voltage at or below 105 kVp, and...
US20170319591 METHODS OF TREATING HEMOGLOBINOPATHIES  
Methods of alleviating the symptoms of hemoglobinopathies, including, but not limited to, sickle cell disease, β-thalassemia, and hemoglobin H disease are provided. In some embodiments, the...
US20170312527 WAVEFORM SHAPES FOR TREATING NEUROLOGICAL DISORDERS OPTIMIZED FOR ENERGY EFFICIENCY  
Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of...
US20170312303 COMPOSITIONS COMPRISING CH848 ENVELOPES AND USES THEREOF  
In certain aspects the invention provides immonogenic compositions comprising CH848 HIV-1 envelopes and their use in methods to induce immune responses in subjects, e.g., human subjects.
US20170311797 WHOLE EYE OPTICAL COHERENCE TOMOGRAPHY(OCT) IMAGING SYSTEMS AND RELATED METHODS  
Whole eye optical coherence tomography (OCT) imaging systems and related methods are disclosed. According to an aspect, an OCT imaging system includes a source having an associated source arm...
9802163 Electrically conducting reverse osmosis membranes  
The disclosure provides composite membranes for use in water purification and filtration.
9802046 Non-regular electrical stimulation patterns for improved efficiency in treating Parkinson's Disease  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20170307349 Non-Invasive Thickness Measurement Using Capacitance Measurement  
Methods of measuring thickness of a material using cross-capacitance. The method generally includes applying a time-varying signal to a first pad and monitoring a response of a capacitor formed by...
US20170306321 SYSTEMS AND METHODS FOR GENETIC ANALYSIS OF INTRACTABLE MICROBES  
Embodiments of the present disclosure relate generally to the genetic analysis of intractable microbes. More particularly, the present disclosure provides materials and methods that incorporate...
US20170304652 Systems and Methods for the Verification of Source Placement for Brachytherapy Radiation Procedures Using Real Time Radiation Detectors  
The present disclosure provides systems and methods for verifying radiation source delivery in brachytherapy by allowing for the radiation source location and dwell time to be determined via...
US20170304488 Compositions and Methods for the Prevention and/or Reduction of Scarring  
The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.
US20170304162 COMPOSITIONS, SYSTEMS AND METHODS FOR THE ENCAPSULATION AND DELIVERY OF A SUBSTANCE  
A composition and method is provided for synthesizing silicone particles with narrow size distributions and tunable degrees of crosslinking for encapsulation of an active ingredient or multiple...
US20170303820 SYSTEMS, COMPOSITIONS AND DEVICES FOR IN VIVO MAGNETIC RESONANCE IMAGING OF LUNGS USING PERFLUORINATED GAS MIXTURES  
Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The...
9800059 Subscription based MISO and MIMO wireless energy transfer  
Subscription based multiple-input-single-output and multiple-input-multiple-output wireless energy transfer enables selective charging and powering of mobile devices using a plurality of spatially...
9797897 Acoustically responsive particles  
Acoustically responsive particles and methods are provided for their use. Methods are provided for making and using tunable, monodisperse acoustically responsive particles and negative contrast...
9797703 Non-invasive thickness measurement using resonant frequency shift  
A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back...
US20170299784 NANOPATCH ANTENNAS AND RELATED METHODS FOR TAILORING THE PROPERTIES OF OPTICAL MATERIALS AND METASURFACES  
Nanopatch antennas and related methods for enhancing and tailoring are disclosed. According to an aspect, an apparatus includes a conductive material defining a substantially planar surface. The...
US20170299655 SIGNAL TRACING USING ON-CHIP MEMORY FOR IN-SYSTEM POST-FABRICATION DEBUG  
A post-fabrication debug and on-line error checking framework for 2D- and 3D-ICs with integrated memories is described. A design-for-debug (DfD) architecture can include, for an IC with on-chip...
US20170298331 GENETIC CORRECTION OF MUTATED GENES  
Disclosed herein are transcription activator-like effector nuclease (TALEN)-related compositions and methods of using said TALENs for correcting mutant genes.
9789154 Plasmonics-active metal nanostar compositions and methods of use  
Plasmonics-active metal nanostars are provided that can be used for treating and detecting cells in a subject. The modes of treatment include a photo-activated drug, which is activated by the...
US20170294248 NOBLE METAL-COATED NANOSTRUCTURES AND RELATED METHODS  
Noble metal-coated nanostructures and related methods are disclosed. According to an aspect, a nanostructure may include a structure comprising a base metal. As an example, the structure may be a...
US20170290650 IMPLANTABLE MESH AND METHOD OF USE  
An implantable mesh for use in reconstructing tissue includes a mesh body and one or more extensions extending from the mesh body. Each mesh extension has a first end and a second end, wherein the...
9782475 Method of treating food allergies by administering a nanoparticle comprising heparin and chitosan encapsulating IL-12  
Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e.g. a cytokine. The cytokine can be selected from the group consisting of TNF, IL-12, IL-2,...
US20170283882 METHODS AND THERAPEUTICS RELATING TO MRNA BIOMARKERS FOR CLINICAL PROGNOSIS OF CANCER  
This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mRNA or downstream expression products thereof. The...
US20170283872 COMPOSITIONS AND METHODS FOR ENHANCING ODORANT RECEPTOR ACTIVITY  
The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine...
US20170282214 METHODS AND SYSTEMS FOR DEPOSITION OF BLENDED POLYMER FILMS  
Methods and systems for deposition of blended polymer films are disclosed. According to an aspect a method of producing a film on a substrate includes combining a guest material, a host matrix,...
US20170281749 COMPOSITIONS COMPRISING CH505 ENVELOPES, AND TRIMERS  
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain...
US20170274037 PEPTIDES FOR SUPPRESSING INFLAMMATION  
Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods...
9771620 Biomarkers of high-grade serous ovarian carcinomas  
The present disclosure provides biomarkers useful for determining the prognosis of conditions such as ovarian cancer. The presently disclosed subject matter provides angiogenic biomarkers and...
9771396 Phase transition biopolymers and methods of use  
The present disclosure describes environmentally responsive polypeptides capable of displaying stimuli-triggered conformational changes in a reversible or irreversible manner that may be...
US20170267651 TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH  
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof....
9768516 Metamaterials for surfaces and waveguides  
Complementary metamaterial elements provide an effective permittivity and/or permeability for surface structures and/or waveguide structures. The complementary metamaterial resonant elements may...
9764026 Compositions, methods, and kits for eliciting an immune response  
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing...
US20170260191 KINASE INHIBITORS AND RELATED METHODS OF USE  
The present disclosure is directed to compounds that may selectively inhibit Death Associated Protein Kinases (DAPKs) as well as PIM kinases. The compounds can be used in methods of treating...
US20170259067 Non-Regular Electrical Stimulation Patterns Designed with a Cost Function for Treating Neurological Disorders  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
9762813 Monocentric lens-based multi-scale optical systems and methods of use  
A monocentric lens-based multi-scale imaging system is disclosed. Embodiments of the present invention comprise a monocentric lens as an objective lens that collects light from a scene....
9760979 Navigator-less segmented diffusion weighted imaging enabled by multiplexed sensitivity-encoded imaging with inherent phase correction  
Diffusion weighted imaging (DWI) and diffusion tensor imaging (DTI) using a new technique, termed multiplexed sensitivity encoding with inherent phase correction, is proposed and implemented to...
US20170254999 MULTISCALE TELESCOPIC IMAGING SYSTEM  
A multiscale telescopic imaging system is disclosed. The system includes an objective lens, having a wide field of view, which forms an intermediate image of a scene at a substantially spherical...
US20170254634 Non-Invasive Thickness Measurement Using Resonant Frequency Shift  
A method of measuring thickness of a material generally includes transmitting an oscillating signal from a first pad, through the material, to a second pad, and measuring the signal reflected back...
9754202 Low power radio frequency communication  
A method, system and tag for low power radio frequency communication is described. In one embodiment, the RF tag comprises: an access point coupled to provide access to a network; an RF tag...
9754139 Real-time wireless power transfer control for passive backscattering devices  
A method and apparatus is disclosed herein for real-time wireless power transfer control. In one embodiment, a system comprises: an RF-energy harvesting sensor tag operable to generate a first...
US20170250805 Reconfigurable Free-Space Quantum Cryptography System  
A system, and methods, for transmitting encrypted information as a quantum transmission between a first node and a second node, or among more than two nodes. Each node is characterized by an...
US20170247765 METHODS FOR RAPID AND SENSITIVE DETECTION OF HOTSPOT MUTATIONS  
Methods that rapidly, sensitively, and specifically detect mutations in IDH1/2 and the TERT promoter employ amplification of particular portions of the genes that experience frequent and...
9747538 Low power radio frequency communication  
A method, system and tag for low power radio frequency communication is described. In one embodiment, the RF tag comprises: an energy harvesting unit operable to convert incident RF energy to...
9744363 Non-regular electrical stimulation patterns for treating neurological disorders  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
9744138 Treatment method and product for uterine fibroids using purified collagenase  
The invention relates to compositions and methods for treating uterine fibroids, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of...
US20170239363 POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME  
Disclosed herein are compositions and methods for reducing the antigenicity of molecules. The antigenicity of a molecule may be reduced or eliminated by conjugating at least one branched polymer...
US20170239352 COMBINATION DRUG THERAPY FOR THE TREATMENT OF SOLID TUMORS  
The present invention relates to a pharmaceutical combination that comprises an IGF1R inhibitor and an mTOR inhibitor for the treatment of cancer in a subject; a pharmaceutical composition...