Patents and Patent Applications from Duke University


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9290489 Activation of TRPV4 ion channel by physical stimuli and critical role for TRPV4 in organ-specific inflammation and itch  
Provided are TRPV4 inhibitor compounds. Further provided are compositions including a TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical...
9289434 Substituted porphyrins  
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby...
US20160077097 METHOD OF ISOLATING CIRCULATING TUMOR CELLS  
Provided are methods for detecting or isolating circulating tumor cells (CTCs) in a subject. The methods may include detecting the expression of at least one epithelial mesenchymal transition...
US20160076086 NANO-PLASMONIC MOLECULAR PROBES AND METHODS OF USE  
Plasmonics-active nanoprobes are provided for detection of target biomolecules including nucleic acids, proteins, and small molecules. The nucleic acids that can be detected include RNA, DNA,...
US20160074541 Prosthetic Compounds for Labeling Internalizing Biomolecules  
Prosthetic compounds are disclosed that are effective for radiolabeling biomolecules with 18F. Representative biomolecules include antibodies (e.g., monoclonal antibodies (mAbs) and nanobodies...
US20160074405 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DRUG-INDUCED HAND-FOOT SYNDROME  
The present invention provides methods of treating, ameliorating or preventing hand-foot syndrome in a subject in need thereof comprising administering to the subject a therapeutically effective...
9284575 Synthetic regulation of gene expression  
Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a...
9283275 Methods and systems for treating cell proliferation disorders using plasmonics enhanced photospectral therapy (PEPST) and exciton-plasmon enhanced phototherapy (EPEP)  
The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents...
US20160068610 GLUTAMATE DEHYDROGENASE IN IDH1- AND IDH2-MUTATED CANCERS  
Expression of GLUD1, GLUD2, or both is tested in gliomas, leukemias, or suspected gliomas and leukemias. Up-regulation of expression is found in IDH1/IDH2 mutant cancers. Inhibition of GLUD1,...
US20160067329 POLYVALENT VACCINE  
The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response...
9279659 Systems and methods for complex conjugate artifact resolved optical coherence tomography  
Systems and methods are disclosed for optical coherence tomography (OCT). For example, imaging can use optical phase modulators based on optical delay lines that, in conjunction with a...
9279012 Method of reducing cell death by administering a nucleic acid encoding a paracrine factor of a mesenchymal stem cell  
A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.
9274001 Dual window processing schemes for spectroscopic optical coherence tomography (OCT) and fourier domain low coherence interferometry  
Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength)...
9268016 Metamaterial devices and methods of using the same  
Compressive imaging captures images in compressed form, where each sensor does not directly correspond with a pixel, as opposed to standard image capture techniques. This can lead to faster image...
9267145 Method of regulating gene expression  
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.
US20160047859 SIGNAL TRACING USING ON-CHIP MEMORY FOR IN-SYSTEM POST-FABRICATION DEBUG  
A post-fabrication debug and on-line error checking framework for 2D- and 3D-ICs with integrated memories is described. A design-for-debug (DfD) architecture can include, for an IC with on-chip...
9260530 Anti-CD19 antibodies and uses in B cell disorders  
The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies and...
9260382 Methods of reducing virulence in bacteria  
A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising...
9259579 Non-regular electrical stimulation patterns for treating neurological disorders using a cost function  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20160039885 RECOMBINANT PRODUCTION OF HIV-1 ENVELOPE GLYCOPROTEINS  
The present invention relates, in general, to HIV-1 and, in particular, to methods of producing HIV-1 envelope (Env) proteins, and subunits thereof, and to constructs suitable for use in such methods.
US20160038740 SYSTEMS AND METHODS FOR ADMINISTERING SPINAL CORD STIMULATION BASED ON TEMPORAL PATTERNS OF ELECTRICAL STIMULATION  
Systems and methods for administering spinal cord stimulation (SCS) based on temporal patterns of electrical stimulation are disclosed. According to an aspect, a method includes using a...
9256977 System for reconstruction of virtual frequency selective inversion MR images  
A virtual frequency selective inversion (VFSI) method receives at least one MR image representative dataset and an associated phase reference dataset, and classifies anatomical material into a...
9256056 Monocentric lens-based multi-scale optical systems and methods of use  
A monocentric lens-based multi-scale imaging system is disclosed. Embodiments of the present invention comprise a monocentric lens as an objective lens that collects light from a scene....
9255927 Methods of developing a prognosis for pancreatic cancer and predicting responsiveness to cancer therapeutics  
Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided herein. The methods include detecting the expression level of at...
9254116 Methods, systems and apparatuses for Van-Cittert Zernike imaging  
A method of creating an ultrasound image includes receiving a return signal from a time delayed signal emitted from a plurality of transducer elements at a target the return signal comprising a...
9254098 System for in vivo magnetic resonance imaging of lungs using perfluorinated gas mixtures  
Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The...
US20160032007 Human Antibody Fragments Against Chondroitin Sulfate Proteoglycan 4 (CSPG4)  
Human antibody fragments against chrondroitin sulfate proteoglycan 4 can be used to deliver cytotoxic agents to cells which express CSPG4. The agents can be diagnostic or therapeutic moieties....
US20160030521 THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES  
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1...
US20160030497 ONCOLYTIC POLIOVIRUS FOR HUMAN TUMORS  
Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. The mechanism of action is believed to involve both viral oncolysis as well as immune...
US20160030332 2-FLUORO-MODIFIED RNAs AS IMMUNOSTIMULATORS  
Methods of inhibiting the growth of cells or inducing cell death by contacting the cells with or introducing into the cells a composition including a 5′ triphosphate, 2′ fluoro-modified pyrimidine...
9249217 Bispecific EGFRvIII x CD3 antibody engaging molecules  
We have constructed bispecific antibody engaging molecules which have one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on its surface, and a second...
US20160024585 METHODS OF PREDICTING RESPONSIVENESS OF A CANCER TO AN AGENT AND METHODS OF DETERMINING A PROGNOSIS FOR A CANCER PATIENT  
The present disclosure provides biomarkers, and methods of using such biomarkers, that are predictive for efficacy of and resistance to an EGFR targeting agent, such as cetuximab, or prognostic...
US20160024035 COMPOSITIONS AND METHODS RELATING TO HEAT SHOCK TRANSCRIPTION FACTOR ACTIVATING COMPOUNDS AND TARGETS THEREOF  
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates,...
US20160022993 SYSTEMS AND METHODS FOR APPLYING ELECTRICAL STIMULATION FOR OPTIMIZING SPINAL CORD STIMULATION  
Systems and methods for applying electrical stimulation to different sub-populations of targeted neurological tissue for optimizing spinal cord stimulation are disclosed. According to an aspect, a...
US20160022772 Cytokine Receptors as Targets for Hypertension Therapy and Methods of Use  
The present disclosure provides methods of treating or ameliorating hypertension in a subject comprising administering a therapeutically effective amount of an IL-1 receptor antagonist.
9245159 Low power radio frequency communication  
A method, system and tag for low power radio frequency communication is described. In one embodiment, the RF tag comprises: an access point comprising: a first antenna; a first radio coupled to...
9245158 Low power radio frequency communication  
A method, system and tag for low power radio frequency communication are described. In one embodiment, the RF tag comprises: a radio, an energy harvesting unit operable to convert incident RF...
9243282 Droplet-based pyrosequencing  
The present invention relates to droplet-based pyrosequencing including a method of identifying a base at a target position in a sample nucleic acid. The method includes: (a) providing a droplet...
9242095 Neural stimulation device with non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20160018364 METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR ESTIMATING SHEAR WAVE SPEED USING STATISTICAL INFERENCE  
Methods, systems and computer program products for determining a mechanical parameter for a sample having a target region, include determining a prior probability density function that...
US20160017038 Bispecific Molecules That are Immunoreactive with Immune Effector Cells That Express an Activating Receptor and an Antigen Expressed by a Cell Infected by a Virus and Uses Thereof  
The present invention relates to bispecific molecules that are capable of localizing an immune effector cell that expresses an activating receptor to a virally infected cell, so as to thereby...
US20160016180 DEVICES, SYSTEMS, AND METHODS FOR ACOUSTICALLY-ENHANCED MAGNETOPHORESIS  
The present disclosure provides systems and devices for the sorting of objects using acoustic waves and magnetic forces as well as methods of using the systems and devices.
US20160016172 Droplet-Based Nucleic Acid Amplification Method and Apparatus  
Aspects of embodiments of the invention relate to a simulator including a visual display capable of outputting to a user a display one or more effects of a command series selected and a system...
US20160005503 PLASMONIC ASSISTED SYSTEMS AND METHODS FOR INTERIOR ENERGY-ACTIVATION FROM AN EXTERIOR SOURCE  
A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy...
US20160003928 MRI WITH REPEATED K-T -SUB-SAMPLING AND ARTIFACT MINIMIZATION ALLOWING FOR FREE BREATHING ABDOMINAL MRI  
Methods of processing MRI image data to reduce or eliminate motion-related artifacts in MRI images includes: electronically repeatedly acquiring sets of 2D or 3D k-space data of a target region of...
US20160003837 BIOMARKERS FOR THE PREDICTION OF PRETERM BIRTH  
The present disclosure provides biomarkers useful for determining the risk of, prognosis of, and/or diagnosis of conditions such as preterm birth in a subject.
US20160002629 DIAGNOSTIC AND TREATMENT FOR CHRONIC AND ACUTE PHASE MYELOID LEUKEMIA  
Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form....
9232618 Up and down conversion systems for production of emitted light from various energy sources including radio frequency, microwave energy and magnetic induction sources for upconversion  
Methods and systems for producing a change in a medium. A first method and system (1) place in a vicinity of the medium at least one upconverter including a gas for plasma ignition, with the...
US20150376259 COMPOSITIONS AND METHODS FOR ENHANCING ODORANT RECEPTOR ACTIVITY  
The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine...
9220713 Compositions and methods for the treatment of drug-induced hand-foot syndrome  
The present invention provides methods of treating, ameliorating or preventing hand-foot syndrome in a subject in need thereof comprising administering to the subject a therapeutically effective...