Patents and Patent Applications from Duke University


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US20160244510 HUMAN MONOCLONAL ANTIBODIES  
The present invention relates, in general, to HIV-1-reactive antibodies and, in at least certain specific embodiments, to broadly neutralizing antibodies (bnAbs) (and fragments and derivatives...
US20160244507 PEPTIDE COMPOUNDS FOR SUPPRESSING INFLAMMATION  
Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods...
US20160243235 METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS USING PLASMONICS ENHANCED PHOTOSPECTRAL THERAPY (PEPST) AND EXCITON-PLASMON ENHANCED PHOTOTHERAPY (EPEP)  
The use of plasmonics enhanced photospectral therapy (PEPST) and exiton-plasmon enhanced phototherapy (EPEP) in the treatment of various cell proliferation disorders, and the PEPST and EPEP agents...
US20160243151 CO-RELEASING COMPOUNDS & FORMULATIONS THEREOF USEFUL FOR INDUCING MITOCHONDRIAL BIOGENESIS AND TISSUE REPAIR  
Provided are pharmacological methods of inducing through a unified set of molecular mechanisms the maturation of stem cells, methods of promoting mitochondrial biogenesis in a cell and tissue,...
US20160243150 Compositions and Methods for Treating Cancer with JAK2 Activity  
Methods and compositions for diagnosing and treating JAK2 inhibitor resistant cancers are disclosed. In the disclosed methods, AKT and/or PI3K inhibitors, ERK/MEK inhibitors, BCL-XL protein...
9421264 Method of treating cancer using selective estrogen receptor modulators  
Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are...
US20160237492 DIAGNOSTIC AND PROGNOSTIC TEST FOR STURGE-WEBER SYNDROME, KLIPPEL-TRENAUNAY-WEBER SYNDROME, AND PORT-WINE STAINS (PWSS)  
The present invention relates to the fields of neurological and skin disorders. More specifically, the present invention provides methods and compositions for diagnosing and prognosing...
US20160237153 NAV1.7 ANTIBODIES AND METHODS OF USING THE SAME  
Disclosed herein is an antibody that binds to a voltage sensor paddle (VSP) of Nav1.7. Also disclosed herein are methods of treating pain, itch, neurogenic inflammation, or cough in a subject in...
US20160235836 MOSAIC HIV ENVELOPE IMMUNOGENIC POLYPEPTIDES  
Disclosed herein are mosaic HIV envelope (Env) polypeptides that can elicit an immune response to HIV (such as cytotoxic T cell (CTL), helper T cell, and/or humoral responses). Also disclosed are...
US20160235292 METHOD AND SYSTEM FOR IMPROVING AIMING DURING OPTICAL COHERENCE TOMOGRAPHY ON YOUNG CHILDREN BY SYNCHRONIZATION WITH RETINAL BIFRINGENCE SCANNING  
The present invention is directed to a method and system for improved aiming during Optical Coherence Tomography (OCT) on young children and those unable to cooperate with OCT imaging by...
9416187 CD-20 specific antibodies and methods of employing same  
The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention...
9415065 Methods of using cerium oxide nanoparticles to mitigate or protect against radiation injury  
Methods of mitigating the effects of radiation exposure or providing a radioprotective effect in a subject are provided herein. The methods include administering a therapeutically effective amount...
US20160231268 DROPLET-BASED SURFACE MODIFICATION AND WASHING  
The present invention relates to droplet-based surface modification and washing. According to one embodiment, a method of splitting a droplet is provided, the method including providing a droplet...
US20160229846 COMPOSITION AND METHODS FOR THE TREATMENT OF CAMKK2-MEDIATED DISORDERS  
The present disclosure provides compositions and methods for treating ocular disorders in mammals especially in and not limited to humans and mice. The present disclosure further provides methods...
US20160229811 TETRA-ARYL CYCLOBUTANE INHIBITORS OF ANDROGEN RECEPTOR ACTION FOR THE TREATMENT OF HORMONE REFRACTORY CANCER  
The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.
9411042 Multi-sensor compressive imaging  
Multi-sensor compressive imaging systems can include an imaging component (such an RF, microwave, or mmW metamaterial surface antenna) and an auxiliary sensing component (such as an EO/IR sensor)....
US20160222218 Tunable Nonfouling Surface Of Oligoethylene Glycol  
An article having a nonfouling surface thereon is comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking...
US20160221958 SUBSTITUTED PYRAZOLES AS HEAT SHOCK TRANSCRIPTION FACTOR ACTIVATORS  
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates,...
US20160221934 Substituted Hydroxamic Acid Compounds  
Disclosed are compounds of formulae: (I), and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, R21, R22, R23, R34, R37, R33, R39, D, Q, Y, X, X1, X3, and...
US20160220592 PROCHELATORS AS BROAD-SPECTRUM ANTIMICROBIAL AGENTS AND METHODS OF USE  
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The...
US20160220467 COSMETIC AND PHARMACEUTICAL COMPOSITIONS AND METHODS USING 2-DECARBOXY-2-PHOSPHINICO DERIVATIVES  
A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions...
9402917 Methods for the induction of broadly anti-HIV-1 neutralizing antibody responses employing liposome-MPER peptide compositions  
The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists...
9402893 Liposome-peptide conjugate and method of using same to induce production of anti-HIV antibodies  
The present invention relates to a method of inducing the production of anti-HIV antibodies. The method comprises administering at least one liposome-peptide conjugate, wherein the peptide...
US20160213771 COMPOSITIONS, METHODS AND KITS FOR ELICITING AN IMMUNE RESPONSE  
The present invention relates to compositions, methods, and kits for eliciting an immune response to at least one CMV antigen expressed by a cancer cell, in particular for treating and preventing...
9399662 Concurrent chemotherapy and immunotherapy  
The concurrent administration of chemotherapy and immunotherapy has been considered a contraindication because of the concern that the induced lymphopenia would ablate therapeutic efficacy of...
9397522 Method and system to control ambient RF energy for wireless devices  
A method and apparatus is disclosed herein for controlling radio-frequency (RF) energy for wireless devices. In one embodiment, the method comprises determining to increase radio-frequency (RF)...
9395617 Panoramic multi-scale imager and method therefor  
A panoramic imager comprising a mirror and a multi-scale imaging system is presented. The multi-scale imaging system comprises an objective lens and a plurality of cameras that is arranged in a...
9395361 Bead incubation and washing on a droplet actuator  
The invention relates to bead incubating and washing on a droplet actuator. Methods for incubating magnetically responsive beads that are labeled with primary antibody, a sample (i.e., analyte),...
US20160204515 DISCRETE-DIPOLE METHODS AND SYSTEMS FOR APPLICATIONS TO COMPLEMENTARY METAMATERIALS  
Discrete-dipole methods and systems for applications to complementary metamaterials are disclosed. According to an aspect, a method includes identifying a discrete dipole interaction matrix for a...
US20160201089 RNA-GUIDED GENE EDITING AND GENE REGULATION  
Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of using said CRISPR/Cas9-based...
US20160200682 2-Piperidinyl Substituted N,3-Dihydroxybutanamides  
Disclosed are compounds of formulae: (I) and pharmaceutically acceptable salts thereof, wherein the variables, R1, R2, Y, and Z are defined herein. These compounds are useful for treating...
US20160200673 Antibacterial Compounds  
Disclosed are compounds of formulae (I) and (II) and pharmaceutically acceptable salts thereof, wherein the variables, R, R1, R2, R3, Y, Z, X, R12, R17, R18, R19, Y1, Z1, X1, and X2 are defined...
US20160199363 TRPA1 AND TRPV4 INHIBITORS AND METHODS OF USING THE SAME FOR ORGAN-SPECIFIC INFLAMMATION AND ITCH  
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof....
US20160195543 PREDICTING CORONARY ARTERY DISEASE AND RISK OF CARDIOVASCULAR EVENTS  
Methods of assessing the risk of cardiovascular disease in a subject by detecting the level of at least one metabolite in a sample from the subject are disclosed herein. The level of the...
US20160194715 MOLECULAR PREDICTORS OF FUNGAL INFECTION  
Methods for identifying fungal infection, assays for identifying genomic and protein markers of fungal infection, and methods for diagnosing the fungal infection. In one aspect, the method of...
US20160194312 ACTIVATION OF TRPV4 ION CHANNEL BY PHYSICAL STIMULI AND CRITICAL ROLE FOR TRPV4 IN ORGAN-SPECIFIC INFLAMMATION AND ITCH  
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof....
9384582 Methods and computer program products for quantitative three-dimensional image correction and clinical parameter computation in optical coherence tomography  
Methods and computer program products for quantitative three-dimensional (“3D”) image correction in optical coherence tomography. Using the methods and computer program products, index interface...
US20160187676 POLYMER OPTICAL ISOLATOR  
Various optical isolators are disclosed. One embodiment provides an optical isolator comprising a waveguide that includes polymer magneto-optical media. In a particular embodiment, the waveguide...
US20160187269 VOLUMETRIC-MOLECULAR-IMAGING SYSTEM AND METHOD THEREFOR  
An imaging system operative for providing a volumetric molecular image of an object is disclosed. The imaging system interrogates the object with structured x-ray radiation while continuous...
US20160184410 TREATMENT OF GLYCOGEN STORAGE DISEASE TYPE II  
Methods of treating glycogen storage disease type II, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II.
US20160175351 CANCER TREATMENT  
Described herein are methods of inhibiting the proliferation of cancer cells and methods of treating cancer, as well as methods of predicting responsiveness of subjects to certain cancer...
9370556 Treatment of glycogen storage disease type II  
Methods of treating glycogen storage disease type II, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II.
US20160171688 SEGMENTATION AND IDENTIFICATION OF LAYERED STRUCTURES IN IMAGES  
Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes...
US20160169998 METHOD FOR CREATING HYPERPOLARIZATION AT MICROTESLA MAGNETIC FIELDS  
Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.
US20160168263 Certain Improved Human Bispecific EGFRvIII Antibody Engaging Molecules  
We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on...
9367601 Cost-based optimization of configuration parameters and cluster sizing for hadoop  
Cost-based optimization of configuration parameters and cluster sizing for distributed data processing systems are disclosed. According to an aspect, a method includes receiving at least one job...
9365593 Photolabile caged transition metal complexes and methods of using the same  
The present invention provides compounds of Formula I: along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
US20160160188 PEG-Urate Oxidase Conjugates and Use Thereof  
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of...
US20160158555 NON-REGULAR ELECTRICAL STIMULATION PATTERNS FOR TREATING NEUROLOGICAL DISORDERS  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20160154102 SYSTEMS AND METHODS FOR USING TIME OF FLIGHT MEASUREMENTS FOR IMAGING TARGET OBJECTS  
An imaging system as disclosed can include multiple bistatic radar sensors configured to transmit electromagnetic waves towards a surface of a target object and configured to measure the...