Patents and Patent Applications from Duke University


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9370556 Treatment of glycogen storage disease type II  
Methods of treating glycogen storage disease type II, by administering acid α-glucosidase, are described, as are compositions for use in treatment of glycogen storage disease type II.
US20160171688 SEGMENTATION AND IDENTIFICATION OF LAYERED STRUCTURES IN IMAGES  
Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes...
US20160169998 METHOD FOR CREATING HYPERPOLARIZATION AT MICROTESLA MAGNETIC FIELDS  
Provided are methods for nuclear spin polarization enhancement via signal amplification by reversible exchange at very low magnetic fields.
US20160168263 Certain Improved Human Bispecific EGFRvIII Antibody Engaging Molecules  
We have constructed a polynucleotide encoding a bispecific antibody engaging molecule which has one arm that specifically engages a tumor cell which expresses the human EGFRvIII mutant protein on...
9367601 Cost-based optimization of configuration parameters and cluster sizing for hadoop  
Cost-based optimization of configuration parameters and cluster sizing for distributed data processing systems are disclosed. According to an aspect, a method includes receiving at least one job...
9365593 Photolabile caged transition metal complexes and methods of using the same  
The present invention provides compounds of Formula I: along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
US20160160188 PEG-Urate Oxidase Conjugates and Use Thereof  
A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of...
US20160158555 NON-REGULAR ELECTRICAL STIMULATION PATTERNS FOR TREATING NEUROLOGICAL DISORDERS  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20160154102 SYSTEMS AND METHODS FOR USING TIME OF FLIGHT MEASUREMENTS FOR IMAGING TARGET OBJECTS  
An imaging system as disclosed can include multiple bistatic radar sensors configured to transmit electromagnetic waves towards a surface of a target object and configured to measure the...
US20160152980 METHOD OF REGULATING GENE EXPRESSION  
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.
9353418 Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma  
We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from...
9353168 Method of reducing cell death by administering a paracrine factor derived from a mesenchymal stem cell  
A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death and/or tissue injury associated with ischemic conditions.
US20160146822 METHODS OF DEVELOPING A PROGNOSIS FOR PANCREATIC CANCER AND PREDICTING RESPONSIVENESS TO CANCER THERAPEUTICS  
Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided herein. The methods include detecting the expression level of at...
US20160143884 USE OF TETRAHYDROINDAZOLYLBENZAMIDE AND TETRAHYDROINDOLYLBENZAMIDE DERIVATIVES FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) AND ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS)  
Provided are methods of treating or inhibiting Human Immunodeficiency Virus (HIV) infection, or treating or inhibiting Acquired Human Immunodeficiency Syndrome (AIDS) in a subject in need thereof,...
9346837 Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives  
A method for treating hair loss in mammals uses compositions containing 2-decarboxy-2-phosphinico prostaglandin derivatives. The compositions can be applied topically to the skin. The compositions...
9346784 Phenyl-substituted nicotinic ligands, and methods of use thereof  
Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy, mania and manic depression, anxiety,...
US20160142646 Monocentric Lens-based Multi-scale Optical Systems and Methods of Use  
A monocentric lens-based multi-scale imaging system is disclosed. Embodiments of the present invention comprise a monocentric lens as an objective lens that collects light from a scene....
US20160136431 Non-Regular Electrical Stimulation Patterns Designed with a Cost Function for Treating Neurological Disorders  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20160135790 SYSTEMS AND METHODS FOR ULTRASOUND MOTION DISPLAY AND ANALYSIS  
A method of generating an image of a scanned subject includes: emitting, by multiple ultrasonic elements of an array, multiple respective ultrasonic signals into a subject, the multiple respective...
9340591 Method of modulating the activity of a nucleic acid molecule  
The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic...
US20160129282 SYSTEMS AND METHODS FOR SPECIFYING TREATMENT CRITERIA AND TREATMENT PARAMETERS FOR PATIENT SPECIFIC RADIATION THERAPY PLANNING  
Disclosed herein are systems and methods for specifying treatment criteria and treatment planning parameters for patient specific radiation therapy planning. According to an aspect, a method...
US20160129258 WAVEFORM SHAPES FOR TREATING NEUROLOGICAL DISORDERS OPTIMIZED FOR ENERGY EFFICIENCY  
Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of...
9335281 Apparatus for coded aperture X-ray scatter imaging and method therefor  
A system and method for producing images of the structure and composition of an object based on measurements of the low-angle x-ray diffraction properties of the object. The imaging system...
9335154 Systems and methods of angle-resolved low coherence interferometry based optical correlation  
Systems and methods of angle-resolved low coherence interferometry based optical correlation are disclosed. According to an aspect, a method includes directing a sample beam towards a sample for...
9333213 Prochelators as broad-spectrum antimicrobial agents and methods of use  
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The...
US20160122733 METHOD OF TREATING GLYCOGEN STORAGE DISEASE  
The disclosure relates, in general, to Glycogen Storage Disease and, in particular, to a method of treating Glycogen Storage Disease and to compounds and compositions suitable for use in such a...
US20160122451 ENZYME-CATALYZED SYNTHESIS OF SITE-SPECIFIC AND STOICHIOMETRIC BIOMOLECULE-POLYMER CONJUGATES  
Methods for producing polypeptide-polymer conjugates include attachment of an initiator agent to a polypeptide specifically at the C-terminus of the polypeptide using a sortase enzyme and in situ...
US20160120952 THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES  
The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1...
9328154 Therapeutic agents comprising fusions of growth hormone and elastic peptides  
The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. In some...
US20160116556 RF COIL ELEMENTS WITH SPLIT DC LOOPS FOR MAGNETIC RESONANCE IMAGING SYSTEMS FOR INTEGRATED PARALLEL RECEPTION, EXCITATION, AND SHIMMING AND RELATED METHODS AND DEVICES  
Systems, methods and devices are configured for integrated parallel reception, excitation, and shimming (iPRES) with RF coil elements with split DC loops. Parallel transmit/receive (which can...
US20160115205 POLYVALENT HIV-1 IMMUNOGEN  
The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.
US20160114320 Droplet Manipulation Device  
Methods are provided for manipulating droplets. The methods include providing the droplet on a surface comprising an array of electrodes and a substantially co-planer array of reference elements,...
US20160114053 METHODS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS WITH ENHANCED PHARMACOLOGICAL PROPERTIES  
Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like...
US20160113548 SYSTEMS, METHODS, COMPOSITIONS AND DEVICES FOR IN VIVO MAGNETIC RESONANCE IMAGING OF LUNGS USING PERFLUORINATED GAS MIXTURES  
Systems and methods for generating MRI images of the lungs and/or airways of a subject using a medical grade gas mixture comprises between about 20-79% inert perfluorinated gas and oxygen gas. The...
US20160109459 Compositions And Methods For Heparan Sulfate As A Biomarker For Transplant Rejection  
The present disclosure provides methods of identifying transplant rejection through the use of heparan sulfate as a biomarker. Method also comprise treating and/or preventing transplant rejection...
US20160108433 SYSTEMS, APPARATUS, AND METHODS FOR DROPLET-BASED MICROFLUIDICS CELL PORATION  
The present disclosure provides systems, apparatus, and methods that include an electrowetting-on-dielectric microfluidic apparatus for effecting poration of cells in a droplet.
US20160106827 V3 IMMUNOGENS  
The present invention relates, in general, to human immunodeficiency virus (HIV), and, in particular, to a vaccine for HIV-1, comprising synthetic V3 glycopeptides, and to methods of making and...
US20160106773 TREATMENT FOR DISEASES RELYING ON DISCOVERY THAT THIOREDOXIN MEDIATES NITRIC OXIDE RELEASE IN CELLS  
Patients having a disease associated with high level of thioredoxin system activity or a requirement for nitric oxide, e.g. large cell lymphoma or restenosis, are treated with a thioredoxin...
US20160106720 MACROCYCLIC COMPOUNDS AND METHODS OF TREATMENT  
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating bone processes, and methods of treating...
US20160106651 COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS USING NON-NATURALLY OCCURRING PROSTAGLANDINS  
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
9315449 Substituted pyrazoles as heat shock transcription factor activators  
The present invention relates to substituted pyrazole compounds, methods for their discovery, and their research and therapeutic uses, and pharmaceutical Formulations thereof. In particular, the...
9309572 Acid ceramidase polymorphisms and methods of predicting traits using the acid ceramidase polymorphisms  
Provided are methods of predicting a trait in a subject including obtaining information about at least a portion of a polynucleotide sequence of the subject, the polynucleotide sequence encoding...
US20160097099 BIOMARKERS FOR THE MOLECULAR CLASSIFICATION OF BACTERIAL INFECTION  
Disclosed herein are biomarkers useful for identifying and/or classifying bacterial infections in a subject.
9303063 Peptide compounds for suppressing inflammation  
Provided herein are peptides that exhibit ApoE biological activity, as well as compositions and pharmaceutical formulations that include the peptides. The peptides, compositions, and methods...
9302116 Non-invasive energy upconversion methods and systems for in-situ photobiomodulation  
Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases...
9301999 Peptide, adjuvants, vaccines, and methods of use  
Provided herein are peptides that have activity as mast cell activating proteins (MCAP), as well as compositions, adjuvant compositions, vaccines, and pharmaceutical formulations that include the...
9299155 Segmentation and identification of layered structures in images  
Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes...
US20160084948 SYSTEMS, METHODS AND COMPUTER PROGRAM PRODUCTS FOR DOPPLER SPATIAL COHERENCE IMAGING  
Methods, systems and computer program products for imaging fluid in a sample include acquiring a plurality of echo signals for a region of interest in the sample from a plurality of ultrasound...
US20160082035 IMMUNOMODULATING GENE THERAPY  
The present invention relates, in general, to Pompe disease and, in particular, to a methods of treating Pompe disease and to compounds/constructs suitable for use in such methods.
US20160081858 Compositions and Methods for the Prevention of Scarring and/or Promotion of Wound Healing  
The present disclosure provides methods of preventing and/or reducing scar contracture and methods of promoting wound healing by utilizing an electrospun biocompatible scaffold.