Patents and Patent Applications from Duke University


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US20160374957 SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES  
The present invention concerns the treatment of serotonergic dysregulation disordersand/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and...
9526914 Non-invasive energy upconversion methods and systems  
Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a...
9526913 Non-invasive energy upconversion methods and systems  
A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light,...
9526740 Prochelators as broad-spectrum antimicrobial agents and methods of use  
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The...
US20160367220 ULTRASOUND DEVICE AND METHOD FOR ESTIMATING TISSUE STIFFNESS  
An ultrasound device and method for calculating an estimated tissue stiffness based on peak on-axis tissue displacement propagating along the axis of an acoustic radiation force (ARF) excitation...
9517469 Method and device for conducting biochemical or chemical reactions at multiple temperatures  
Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction...
9517006 Systems and methods for obtaining low-angle circumferential optical access to the eye  
A system for obtaining low-angle circumferential optical access to an eye of a subject. The system includes a light source to generate a beam of light; a beam steering mechanism to steer the beam...
9512106 Smoothened modulators and methods of use thereof  
Compounds of general Formulas (I), (IA), (IB) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting...
US20160348147 SYSTEMS AND DEVICES FOR PROTEASE DETECTION BASED ON ENGINEERED POLYMERS AND BIOPOLYMERS AND METHODS OF USE  
The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity...
US20160345903 System for Accurate Measurement of Dynamics and Kinematics  
A sensor insert is provided for measuring head dynamics and kinematics. The sensor insert includes at least one sensor embedded in the insert. The insert is configured to fit relatively...
9507129 Apparatus comprising a compact catadioptric telescope  
A camera system for a mobile device includes an array of compact catadioptric telescopes wherein at least some of the telescopes have a portion of their aperture truncated. At least some of the...
US20160340741 MUTATIONS DEFINE CLINICAL SUBGROUPS OF GLIOMAS  
Genetic signatures capable of distinguishing among several types of gliomas provide clinically relevant information that can serve as an adjunct to histopathological diagnosis. For example,...
US20160339051 HIV-1 MOTHER-TO-CHILD TRANSMISSION CORRELATES OF PROTECTION AND VACCINE  
The invention provides compositions and methods to induce and boost antibody response, including but not limited to IgG responses binding to HIV-1 in a subject in need thereof, wherein the...
US20160338589 SYSTEMS AND METHODS FOR EYE TRACKING FOR MOTION CORRECTED OPHTHALMIC OPTICAL COHERENECE TOMOGRAPHY  
Systems and methods for eye tracking for motion corrected ophthalmic optical coherence tomography (OCT) are disclosed. According to an aspect, an imaging system includes an eye tracking device...
US20160333392 NON-FOULING POLYMERIC SURFACE MODIFICATION AND SIGNAL AMPLIFICATION METHOD FOR BIOMOLECULAR DETECTION  
An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a...
US20160331801 USE OF CASPASE-2 INHIBITORS TO TREAT AND PREVENT THE METABOLIC SYNDROME  
Methods and compositions for treatment of obesity, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus, dyslipidemia, and nonalcoholic fatty liver disease are discloses. The methods and...
US20160331731 USE OF PSORALEN DERIVATIVES AND COMBINATION THERAPY FOR TREATMENT OF CELL PROLIFERATION DISORDERS  
Methods for the treatment of a cell proliferation disease or disorder in a subject, involving applying a psoralen derivative lacking a DNA cross-linking motif to cancer cells, applying a psoralen...
US20160331730 Antifungal Compounds  
The technical field of the invention is in pharmaceutical compounds and methods. In an aspect, the disclosure provides macrolide compounds suitable for use as antifungal agents, as well as methods...
9494771 Quasi-monocentric-lens-based multi-scale optical system  
Optical systems based on an objective lens comprising one or more plastic lens elements are disclosed. The inclusion of plastic lens element reduces one or more of system cost, size, weight,...
9493837 Genes causing hereditary kidney disease or malformation of the urinary tract  
Isolated nucleotides encoding polypeptides with mutations leading to amino acid substitutions linked to hereditary kidney disease or malformation of the urinary tract are provided herein....
9493823 Non-fouling polymeric surface modification and signal amplification method for biomolecular detection  
An article such as a biosensor having a nonfouling surface thereon is described. The article comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; (c) a...
9492564 Dual specific immunotoxin for brain tumor therapy  
We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a...
9492532 Nucleic acids encoding mosaic HIV-1 gag proteins  
The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of...
9492385 Temperature-sensitive liposomal formulation  
A liposome contains an active agent and has a gel-phase lipid bilayer membrane comprising phospholipid and a surface active agent. The phospholipids are the primary lipid source for the lipid...
US20160325111 NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION  
Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases...
US20160324868 METHODS OF TREATING PRURITUS  
A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a...
US20160324808 METHOD OF TREATING CANCER USING SELECTIVE ESTROGEN RECEPTOR MODULATORS  
Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are...
US20160317648 CAP260, CAP174 AND K0224 HIV-1 ENVELOPES, PEPTIDE AND COMPOSITIONS  
The invention is directed to HIV-1 envelope proteins and peptides, and compositions comprising the same to increase the breadth of vaccine coverage of the V1 V2 env region of clade C HIV-1.
9483957 Methods, systems, and computer readable media for promoting behavioral intervention via evidence-based recommendations and game mechanics  
The subject matter described herein includes methods, systems, and computer readable media for promoting behavioral intervention via evidence-based recommendations and game mechanics. According to...
9482720 Non-invasive pre-bond TSV test using ring oscillators and multiple voltage levels  
A design for test (DfT) architecture is provided that enables pre-bond parametric testing of through-silicon vias (TSVs). A grouping of N number of input/output (I/O) segments are configured to...
US20160314602 MULTI-SENSOR COMPRESSIVE IMAGING  
Multi-sensor compressive imaging systems can include an imaging component (such an an RF, microwave, or mmW metamaterial surface antenna) and an auxialiary sensing component (such as an EO/IR...
US20160311893 INHIBITORS OF COMPLEMENT FACTOR H  
Disclosed herein are Complement factor H (CFH) inhibitors, such as anti-CFH antibodies and small molecules, and methods of using said inhibitors.
9476856 Droplet-based affinity assays  
A method of detecting a target analyte in a sample, including executing electrowetting-mediated droplet operations and thereby: combining one or more immunoassay reagent droplets comprising...
9468650 Inhibition of endosomal toll-like receptor activation  
The present invention relates, in general, to pattern-recognition receptors (PRRs), including toll-like receptors (TLRs), and, in particular, to a method of inhibiting nucleic acid-induced...
9468627 Slow-release formulations of 5-hydroxytryptophan as an adjunct to pro-serotonergic therapies  
The present invention concerns the treatment of serotonergic dysregulation disorders and/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and...
US20160290867 MULTIPLE WINDOW PROCESSING SCHEMES FOR SPECTROSCOPIC OPTICAL COHERENCE TOMOGRAPHY (OCT) AND FOURIER DOMAIN LOW COHERENCE INTERFEROMETRY  
Current apparatuses and methods for analysis of spectroscopic optical coherence tomography (SOCT) signals suffer from an inherent tradeoff between time (depth) and frequency (wavelength)...
US20160289297 REVERSIBLE PLATELET INHIBITION  
The present invention relates, in general, to receptors and to platelet aggregation and, in particular, to a method of inhibiting platelet aggregation using an aptamer that binds to and inhibits...
US20160287575 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES INVOLVING HIPPO PATHWAY  
Provided herein are interfering molecules and pharmaceutical combinations comprising such interfering molecules that modulate the Hippo signaling pathway. Also provided are methods of treating and...
US20160287123 METHOD AND SYSTEM FOR EVALUATING STABILITY OF CARDIAC PROPAGATION RESERVE  
A method of determining the susceptibility to ventricular arrhythmias in a subject, the method including determining a reserve of refractoriness (RoR) and a reserve of memory (RoM) and combining...
US20160287063 COLPOSCOPES HAVING LIGHT EMITTERS AND IMAGE CAPTURE DEVICES AND ASSOCIATED METHODS  
Colposcopes having light emitters and image capture devices and associated methods are disclosed. According to an aspect, a colposcope includes an elongate body having a distal end, a proximate...
9458218 Therapeutic agents comprising fusions of insulin and elastic peptides  
The present invention provides therapeutic agents and compositions comprising elastic peptides and therapeutic proteins. Such peptides exhibit a flexible, extended conformation. In some...
9456835 Methods and apparatuses for generating a steerable pressure field in a shock wave lithotripter  
Lithotripter apparatuses and methods are provided for selectively modifying an acoustic pressure field and can include a shock wave source operable to generate a shock wave having a substantially...
US20160286137 METHOD FOR COMBINING MULTIPLE IMAGE FIELDS  
Methods for stitching multiple sub-images together to form a substantially seamless composite image are disclosed. Overlap regions formed by each pair of neighboring sub-images are periodically...
US20160281107 SYNTHETIC REGULATION OF GENE EXPRESSION  
Synthetic regulation of gene expression is provided. In some embodiments, synthetic regulatory constructs are provided. In some embodiments, a synthetic regulatory construct expresses a...
9452433 Method and device for conducting biochemical or chemical reactions at multiple temperatures  
Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction...
US20160272730 Antibodies for Tumor Gangliosides  
High affinity antibodies were made to gangliosides expressed on tumor cells. The antibodies can be used analytically, diagnostically, therapeutically, and theranostically. The antibodies may be...
US20160271262 HYDROGELS FORMED FROM POLYPEPTIDE MICELLES AND METHODS OF USE THEREOF  
The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of...
US20160271244 METHOD OF INDUCING THE PRODUCTION OF PROTECTIVE ANTI-HIV-1 ANTIBODIES  
The present invention relates, in general, to an immunogen for HIV vaccination and, in particular, to a method of inducing the production of protective anti-HIV antibodies by targeting B cell...
US20160271240 Tetanus Toxoid and CCL3 Improve DC Vaccines  
Pre-conditioning a vaccine site with a potent recall antigen such as tetanus/diphtheria (Td) toxoid can significantly improve the lymph node homing and efficacy of tumor antigen-specific DC...
9448056 System for fourier domain optical coherence tomography  
Optical coherence tomography (OCT) is an imaging method which can image with micrometer-scale resolution up to a few millimeters deep into, for example, living biological tissues and preserved...