Patents and Patent Applications from Duke University


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US20170065568 METHODS AND COMPOUNDS FOR CALCIUM ION CHANNEL REGULATION  
The present invention generally relates to methods of modulating Cav1.2 channels and Cav1.2 channel activators.
9589346 Segmentation and identification of layered structures in images  
Disclosed herein are systems and method for segmentation and identification of structured features in images. According to an aspect, a method may include representing an image as a graph of nodes...
9588120 Methods of subclassification of ductal carcinoma in situ of the breast  
Provided herein are methods of determining the aggressiveness or indolence of a ductal carcinoma in situ lesion. Also provided are methods of development treatment plans for subjects with a ductal...
9585998 Arteriovenous graft for hemodialysis with puncture-resistant posterior and side walls  
An arteriovenous dialysis access graft configured to be implanted in a subject includes: at least one flexible conduit having first and second end portions, wherein the first end portion is...
9585850 Methods of treatment using arylcyclopropylamine compounds  
The present invention is directed to a method of treating Parkinson's disease using arylcyclopropylamine compounds. The arylcyclopropylamine compounds have the following formula wherein R1, R2,...
US20170064204 SYSTEMS AND METHODS FOR BURST IMAGE DELURRING  
System and Method for automatically removing blur and noise in a plurality of digital images. The system comprises an electronic processor configured to receive the plurality of digital images,...
US20170062895 RAPID RADIO FREQUENCY (RF) WAVEGUIDE COMPONENTS AND RELATED METHODS  
Rapid radio frequency (RF) microwave devices and methods are disclosed. According to an aspect, a waveguide includes a body having first and second components that are attachable together to form...
US20170059829 QUASI-MONOCENTRIC-LENS-BASED MULTI-SCALE OPTICAL SYSTEM  
Optical systems based on an objective lens comprising one or more plastic lens elements are disclosed. The inclusion of plastic lens element reduces one or more of system cost, size, weight,...
US20170056532 HYPERPOLARIZED NOBLE GAS PRODUCTION SYSTEMS WITH NANOCLUSTER SUPPRESSION, DETECTION AND/OR FILTERING AND RELATED METHODS AND DEVICES  
Systems, methods and related devices used to produce and collect polarized noble gas to inhibit, suppress, detect or filter alkali metal nanoclusters to preserve or increase a polarization level...
9579523 Plasmonic assisted systems and methods for interior energy-activation from an exterior source  
A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy...
9579270 Compositions and methods for treating hair loss using non-naturally occurring prostaglandins  
A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss,...
US20170051064 Dual Specific Immunotoxin for Brain Tumor Therapy  
We tested the in vitro and in vivo efficacy of a recombinant bispecific immunotoxin that recognizes both EGFRwt and tumor-specific EGFRvIII receptors. A single chain antibody was cloned from a...
US20170050046 TUMOR IMAGING WITH X-RAYS AND OTHER HIGH ENERGY SOURCES USING AS CONTRAST AGENTS PHOTON-EMITTING PHOSPHORS HAVING THERAPEUTIC PROPERTIES  
A system and method for imaging or treating a disease in a human or animal body. The system provides to the human or animal body a pharmaceutical carrier including one or more phosphors which are...
US20170049909 COMPOSITIONS FOR THE INACTIVATION OF VIRUS REPLICATION AND METHODS OF MAKING AND USING THE SAME  
Provided herein are recombinant constructs, vectors and expression cassettes including a first promoter which is suitably a tRNA promoter operably connected to a first polynucleotide encoding a...
9572988 Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders  
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse...
US20170043178 NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS  
Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases...
US20170037544 ELECTROSPUN CATIONIC NANOFIBERS AND METHODS OF MAKING AND USING THE SAME  
Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition,...
US20170037471 METHODS FOR DIAGNOSING & TREATING COPPER-DEPENDENT DISEASES  
Described are methods and materials for diagnosing a subject's predisposition for cardiovascular disease by detecting a copper deficiency genetic marker, as well as methods of alleviating Cu...
US20170035743 2,5-Disubstituted-Pyridyl Nicotinic Ligands, and Methods of Use Thereof  
Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic...
9562913 Method for liberating and detecting nitric oxide from nitrosothiols and iron nitrosyls in blood  
Amount of combined nitric oxide or nitric oxide presented as iron nitrosyls in a blood sample is determined by directing a low power electromagnetic radiation beam at a blood sample to liberate...
9561292 Nanostars and nanoconstructs for detection, imaging, and therapy  
A polymer-free synthesis method is provided for preparation of monodisperse nanostars. The nanostars can be used for treating and imaging cells in in vivo or ex vivo. The modes of treatment...
US20170027928 CAMKK-BETA AS A TARGET FOR TREATING CANCER  
Provided herein are compounds, compositions, including pharmaceutical compositions, having anti-cancer activity. Also provided are methods for diagnosing, detecting, and treating cancer in a...
9556486 Methods of identifying individuals at risk of perioperative bleeding, renal dysfunction or stroke  
The present invention relates, in general, to perioperative bleeding and, in particular, to methods of identifying individuals at risk of perioperative bleeding. The present invention relates, in...
US20170022498 METHOD OF REGULATING GENE EXPRESSION  
The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method.
US20170020994 MATERIALS AND METHODS FOR THE TREATMENT OF LATENT VIRAL INFECTION  
The subject invention pertains to materials and methods for the treatment of latent viral infections.
US20170020828 Use of Disulfiram for Inflammatory Breast Cancer Therapy  
Methods, compositions of matter, and kits for treatment of breast cancer, and in particular for inflammatory breast cancer, in a patient are disclosed. The methods can include administering a...
US20170016915 SCREENING TARGETS AND COMPOSITIONS AND METHODS FOR TREATMENT OF CILIOPATHY DISORDERS  
The present disclosure provides methods of screening and compositions and methods for treating ciliopathy diseases. Methods are provided for screening for molecules to treat ciliopathy disorders...
US20170015758 Compositions And Methods For Modulating And Redirecting Immune Responses  
Provided herein are methods of modulating and redirecting an immune response. Compositions and methods for killing targeted cells in a cell population are also provided wherein, a cell population...
US20170014503 MPER-LIPOSOME CONJUGATES AND USES THEREOF  
The present invention relates to peptides and compositions suitable for use in inducing anti-HIV-1 antibodies. The compositions comprise HIV-1 gp41 membrane proximal external region (MPER)...
US20170014402 METHODS AND COMPOSITIONS FOR TREATING CANCER THROUGH INHIBITION OF PI3K  
Provided herein are methods for treating cancer relating to inhibition of PI3K, as pharmaceutical compositions comprising a PI3K inhibitor and a PAK1 inhibitor.
US20170014108 SYSTEMS AND METHODS FOR EXTRACTING PROGNOSTIC IMAGE FEATURES  
Described herein are systems and methods for extracting image features from magnetic resonance imaging scans. These methods and systems are useful for both determining cancer lesion severity and...
9547188 Polymer optical isolator  
Various optical isolators are disclosed. One embodiment provides an optical isolator comprising a waveguide that includes polymer magneto-optical media. In a particular embodiment, the waveguide...
US20170003389 METAMATERIAL DEVICES AND METHODS OF USING THE SAME  
Compressive imaging captures images in compressed form, where each sensor does not directly correspond with a pixel, as opposed to standard image capture techniques. This can lead to faster image...
US20170003340 NON-INVASIVE PRE-BOND TSV USING RING OSCILLATORS AND MULTIPLE VOLTAGE LEVELS  
A design for test (DfT) architecture is provided that enables pre-bond parametric testing of through-silicon vias (TSVs). A grouping of N number of input/output (I/O) segments are configured to...
US20170002417 COMPOSITIONS AND METHODS FOR IDENTIFYING ALTERED EFFECTIVENESS OF BETA BLOCKER THERAPY  
The present invention provides a method of identifying a human subject as having an increased risk of altered effectiveness of beta blocker therapy, comprising detecting in the subject one or more...
US20170000768 COMPOSITIONS AND METHODS RELATING TO HEAT SHOCK TRANSCRIPTION FACTOR ACTIVATING COMPOUNDS AND TARGETS THEREOF  
The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates,...
US20160377602 IMMUNE MONITORING TO PREDICT AND PREVENT INFECTION  
Methods of evaluating the risk of infection after transplantation or immunosuppression in a subject are provided. Methods of determining whether a subject should be treated prophylactically with...
US20160376655 TRPC6 INVOLVED IN GLOMERULONEPHRITIS  
Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a...
US20160375059 REGULATORY B CELLS AND THEIR USES  
The present invention relates to a phenotypically distinct CD1dhighCD5+ B cell subset that regulates T cell mediated inflammatory responses through the secretion of interleukin-10 (IL-10). The...
US20160374957 SLOW-RELEASE FORMULATIONS OF 5-HYDROXYTRYPTOPHAN AS AN ADJUNCT TO PRO-SEROTONERGIC THERAPIES  
The present invention concerns the treatment of serotonergic dysregulation disordersand/or augmentation of serotonin levels in the brain by add-on treatments to serotonin enhancers, and...
9526914 Non-invasive energy upconversion methods and systems  
Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a...
9526913 Non-invasive energy upconversion methods and systems  
A nanoparticle-based system for enhancement of emitted light inside a medium. The nanoparticle-based system includes a phosphorescent material which, upon activation, produces the emitted light,...
9526740 Prochelators as broad-spectrum antimicrobial agents and methods of use  
The present disclosure provides methods of treating (including ameliorating and/or preventing) pathogenic infections by administering a therapeutically effective amount of a prochelator. The...
US20160367220 ULTRASOUND DEVICE AND METHOD FOR ESTIMATING TISSUE STIFFNESS  
An ultrasound device and method for calculating an estimated tissue stiffness based on peak on-axis tissue displacement propagating along the axis of an acoustic radiation force (ARF) excitation...
9517469 Method and device for conducting biochemical or chemical reactions at multiple temperatures  
Methods and devices for conducting chemical or biochemical reactions that require multiple reaction temperatures are described. The methods involve moving one or more reaction droplets or reaction...
9517006 Systems and methods for obtaining low-angle circumferential optical access to the eye  
A system for obtaining low-angle circumferential optical access to an eye of a subject. The system includes a light source to generate a beam of light; a beam steering mechanism to steer the beam...
9512106 Smoothened modulators and methods of use thereof  
Compounds of general Formulas (I), (IA), (IB) are described, along with compositions containing the same and methods of use thereof, inhibiting the hedgehog pathway in a cell or inhibiting...
US20160348147 SYSTEMS AND DEVICES FOR PROTEASE DETECTION BASED ON ENGINEERED POLYMERS AND BIOPOLYMERS AND METHODS OF USE  
The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity...
US20160345903 System for Accurate Measurement of Dynamics and Kinematics  
A sensor insert is provided for measuring head dynamics and kinematics. The sensor insert includes at least one sensor embedded in the insert. The insert is configured to fit relatively...
9507129 Apparatus comprising a compact catadioptric telescope  
A camera system for a mobile device includes an array of compact catadioptric telescopes wherein at least some of the telescopes have a portion of their aperture truncated. At least some of the...