Patents and Patent Applications from Dartmouth College


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9896475 Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole  
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a tnterpenoid compound of...
9896460 Molecular switches based on cis/trans isomerization of BF2-coordinated azo compounds  
Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans isomerization process. Methods of...
US20180047769 GATELESS RESET FOR IMAGE SENSOR PIXELS  
Some embodiments of the present disclosure are directed to an image sensor pixel that is configured for gateless reset of a floating diffusion. Some embodiments are directed to an image sensor...
9890215 Vista modulators for diagnosis and treatment of cancer  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...
US20180029990 COMPOSITION AND METHOD FOR PREVENTION, MITIGATION OR TREATMENT OF AN ENTEROPATHOGENIC BACTERIAL INFECTION  
Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
9880118 Planar Probe and system for measuring dielectric properties of biological materials  
A probe sensor has a printed circuit comprising a coplanar transmission line, a ground plane, a plated-through contact via, and a part-circular ring of ground vias surrounding the contact via. The...
US20180023100 INCREASED ETHANOL PRODUCTION BY THERMOPHILIC MICROORGANISMS WITH DELETION OF INDIVIDUAL HFS HYDROGENASE SUBUNITS  
Disclosed are methods for engineering bacteria, for example, Thermoanaerobacterium saccharolyticum, that convert biomass to ethanol at high yield by deleting a single gene. Deletion of subunit A...
9873705 Vinylogous thioester compounds and methods of use  
Provided herein are vinylogous thioester compounds and methods for using the compounds.
US20180013970 IMAGE SENSOR WITH CONTROLLABLE NON-LINEARITY  
The present disclosure relates generally to apparatus and methods for image sensing, and, more particularly, to a multi-bit quanta image sensor (QIS) having a controllable (e.g., adjustably...
US20180009896 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND USE IN THERAPY  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
US20180008709 METHODS AND COMPOSITIONS FOR INCREASING SUSCEPTIBILITY TO RADIATION TREATMENT BY INHIBITING SUPPRESSION OF NUMERICAL CHROMOSOMAL INSTABILITY OF CANCER CELLS  
Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it...
US20180006079 MULTI-JUNCTION PIXEL IMAGE SENSOR WITH DIELECTRIC REFLECTOR BETWEEN PHOTODETECTION LAYERS  
Some embodiments provide a color image sensor and color image sampling method that uses multiple-layer pixels and is capable of producing color images without using absorption color filters (e.g.,...
9856478 Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis  
The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone or in combination by inhibiting...
9833476 NKP30 receptor targeted therapeutics  
The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using...
9832206 System, method and authorization device for biometric access control to digital devices  
A system and method for authenticating and continuously verifying authorized users of a digital device includes an authentication device attached to an arm or wrist of authorized users. The...
US20170334990 VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING AGENTS AND USE THEREOF  
The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct,...
9822340 T-cell receptor-deficient T cell compositions  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
9821011 T-cell receptor-deficient T cell compositions  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20170317269 POROUS PIEZOELECTRIC MATERIAL WITH DENSE SURFACE, AND ASSOCIATED METHODS AND DEVICES  
A method for producing a porous piezoelectric polymer film with a dense surface, includes depositing a polymer solution onto a substrate to form a polymer film including a solvent; evaporating a...
9803221 Engineering microorganisms to increase ethanol production by metabolic redirection  
The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting...
US20170306024 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF  
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's...
US20170306020 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF  
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's...
US20170304392 DAB2 INHIBITORS FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS  
Compositions and kits including an agent that inhibits the interaction between Disabled-2 and mutant CFTR proteins, optionally in combination with a CFTR corrector, CFTR potentiator, CAL...
9796985 Compositions and method for modulating the sensitivity of plants to cytokinin  
The present invention includes an expression cassette containing a polynucleotide encoding a polypeptide; and a host cell, transgenic plant (e.g., a dicot or monocot), transformed seed, and...
9796679 Type 4 prepilin peptidase inhibitors and methods of use  
Compounds for inhibiting Type 4 Prepilin Peptidases are provided as are methods of using the compounds as anti-bacterial agents.
US20170298349 INTERGENIC RNAS AND METHODS FOR MODULATING GENE EXPRESSION AND PATHOGENESIS IN CANDIDA  
Intergenic non-coding RNA molecules that regulate the expression of HWP1 and ALS3 of Candida are provided as are methods of using the non-coding RNA molecules and complementary molecules thereof...
9793794 System and method for reducing power loss in switched-capacitor power converters  
A system for reducing power loss in a switched-capacitor converter includes a first and second switched capacitor sub-converter each having a flying capacitor and a first, second, third, and...
9792411 Poroelastic dynamic mechanical analyzer for determining mechanical properties of biological materials  
A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a...
9790278 Anti-B7-H6 antibody, fusion proteins, and methods of using the same  
Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and treatment of disorders associated with B7-H6...
9790186 Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection  
Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
US20170292128 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES  
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with...
9786048 System and method using precious-metal nanoparticle contrast agent for microwave medical imaging  
A system and method of imaging tissue includes administering a contrast agent having charged gold nanoparticles in suspension into a vessel of the subject, such that the nanoparticles are carried...
9775833 Method for the treatment of NF1- or RAS-associated disorders  
Isoxazoloanthrones and a method for treating disorders associated or caused by Ras deregulation or dysregulation, for example, disorders associated with alterations in the neurofibromin 1 gene...
US20170279612 SECURE SYSTEM FOR COUPLING WEARABLE DEVICES TO COMPUTERIZED DEVICES WITH DISPLAYS  
A system has a first electronic device with optical sensor, digital radio transceiver, and processor with firmware; this device is typically portable or wearable. The system also has a...
9774948 System and method for automatically remixing digital music  
Systems and methods augment a target media with a plurality of source media. The target media and source media are processed to form time frequency distributions (TFDs). Target features are...
US20170267713 PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE  
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a tnterpenoid compound of...
9758587 Methods of immune therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
9757440 Method for treating cancer with Toxoplasma gondii vaccine  
The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.
9757359 Synthetic triterpenoids and methods of use in the treatment of disease  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
US20170253857 T-CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20170238849 MOVEMENT MONITORING SYSTEMS AND METHODS  
Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a...
US20170224288 SYSTEMS AND METHODS FOR CARDIOVASCULAR-DYNAMICS CORRELATED IMAGING  
A method for cardiovascular-dynamics correlated imaging includes receiving a time series of images of at least a portion of a patient, receiving a time series of cardiovascular data for the...
9728565 Low full-well capacity image sensor with high sensitivity  
Image sensor pixels having low full-well capacity and high sensitivity for applications such as DIS, qDIS, single/multi bit QIS. Some embodiments provide an image sensor pixel architecture,...
US20170221625 MAGNETIC DEVICES INCLUDING LOW AC RESISTANCE FOIL WINDINGS AND GAPPED MAGNETIC CORES  
A magnetic device having height includes a magnetic core, a first foil winding, and a second foil winding. The magnetic core includes first and second inner posts separated from each other in the...
US20170201177 SYSTEM AND METHOD FOR TWO-PHASE INTERLEAVED DC-DC CONVERTERS  
A two-phase interleaved DC-DC converter includes a first and second switched capacitor sub-converter each including a plurality of switching devices and a flying portion coupling to a switching...
US20170196497 SYSTEM AND METHOD FOR IDENTIFYING ICTAL STATES IN A PATIENT  
A system and method for identifying ictal states in a patient, the system including a plurality of sensors for sensing different non-electroencephalographic signals from the patient, and a...
US20170196237 MATERIAL AND FREEZE CASTING AND IMPREGNATION METHOD OF CARBOHYDRATE SCAFFOLDS  
An edible includes a directionally porous mass of at least one carbohydrate with a low-moisture infiltrate disposed within pores comprising at least one fat selected from melted chocolate, butter,...
9694072 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
US20170167003 OXIDATION RESISTANT HIGH-ENTROPY ALLOYS  
Disclosed herein are new face-centered cubic (f.c.c.) high-entropy alloys with compositions (in atomic %) of FeaNibMncAldCreCf where a is between 37-43 atomic %, b is between 8-14 atomic %, c is...
US20170165317 METHOD FOR MITIGATING OR ALLEVIATING SYNAPTIC AND COGNITIVE DEFICITS  
A method for mitigating or alleviating synaptic and cognitive deficits associated with a β-amyloidogenic disease using a peptide, or derivative or peptidomimetic thereof, derived from the...