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US20120029063 |
CHIMERIC NK RECEPTOR AND METHODS FOR TREATING CANCER
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
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8106028 |
MicroRNA-21 antagonists and its target PDCD4 for use in the treatment of a glioma
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
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US20120022097 |
Compositions and Methods for Treating Cancer
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
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US20120021415 |
Methods for Determining Response to Neoadjuvant Therapy and Survival Using MicroRNA-10b
The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression...
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8101024 |
Removal of minerals from cellulosic biomass
Disclosed is a method for removing minerals from a cellulosic biomass. For example, the biomass may be prewashed with an acid solution and rinsed with water to remove minerals prior to acid...
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8097249 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate D4+ and CD8+ T cell immunity
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
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8084217 |
CD161 ligand, pilar, for modulating activation and proliferation of T cells
The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly...
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8068898 |
Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissues
This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition...
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8067583 |
Method for synthesizing furanosteroids
The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole...
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8067465 |
Tricyclic-bis-enone derivatives and methods of use thereof
Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's...
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8067394 |
Synthesis and biological activities of new tricyclic-bis-enones (TBEs)
This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The...
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US20110278417 |
System And Methods For Smoothly Inverting One Or More Faces Of A Cubical Device
A system and method for inverting a cubical device 100 that inverts one or more faces of the cubical device 100 in a single fluid motion. In an embodiment, the cube faces are split in two face...
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US20110256601 |
MODIFICATION OF HYDROGENASE ACTIVITIES IN THERMOPHILIC BACTERIA TO ENHANCE ETHANOL PRODUCTION
Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced...
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8034955 |
Therapeutic compounds and methods of use
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
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US20110244539 |
Selection Of Cellulolytic Microbes With High Growth Rates
Methods for obtaining cellulolytic microbes with high growth rates are disclosed. For example, C. thermocellum colonies with growth rates higher than 0.17 hr″ 1 have been obtained by the present m...
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8030446 |
Mutant proline-and-arginine rich peptides and methods for using the same
The present invention relates to mutant proline-and-arginine rich (PR) peptides with defined structural characteristics for use in inhibiting mammalian 20S proteasome activity and modulating...
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US20110237656 |
Method of Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
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8000775 |
Systems and methods for tomographic image reconstruction
Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the...
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7994298 |
Chimeric NK receptor and methods for treating cancer
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
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7993659 |
TLR9 agonist and CD40 agonist immunostimulatory combinations
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
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US20110190156 |
MOLECULAR SIGNATURES FOR DIAGNOSING SCLERODERMA
The present invention features methods for classifying, determining severity, and predicting clinical endpoints of scleroderma based upon the expression of selected biomarker genes.
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US20110187100 |
System and Method for Providing Knot Tying
A knot tying system is presented containing a feeding mechanism, a knot tying device, and a clamp. The feeding mechanism has a drive roller and an idle roller capable of guiding a wire. A truck is...
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7981058 |
Intelligent wearable monitor systems and methods
An intelligent wearable monitoring system includes a wireless personal area network for extended monitoring of a patient's motor functions. The wireless personal area network includes an...
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US20110158911 |
Methods for Screening for Antibiotic Compounds
The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
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US20110150876 |
Prognosis and Treatment of Breast Cancer
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
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US20110149281 |
ROTARYFROG SYSTEMS AND METHODS
Systems and methods determining amplitude and phase versus frequency of an incoming beam of pulsed laser light. An apparatus is set to an initial configuration to split the incoming beam into two...
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US20110139964 |
Systems And Methods That Detect Changes In Incident Optical Radiation
Systems, methods and sensors detect changes in incident optical radiation. Voltage is applied across one or more active areas of a detector while the incident optical radiation illuminates the...
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7962198 |
System and method for spectral-encoded high-rate hemodynamic tomography
An optical tomography system has a group of lasers for generating light of multiple distinct wavelengths within a first wavelength band. Light from these lasers is directed into mammalian tissue at...
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7955848 |
MicroRNA biomarkers for human breast and lung cancer
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
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US20110130647 |
System And Method Using Coupler-Resonators For Electron Paramagnetic Resonance Spectroscopy
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor...
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US20110118336 |
Microrna-21 antagonists and its target PDCD4 for use in the treatment of a glioma
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
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7943588 |
Method for preventing or treating neuropathic pain
The present invention is a method for preventing or treating neuropathic pain. Using an agent to decrease the expression or activity of Toll-like receptor 4 (TLR4), behavioral hypersensitivity is...
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7939499 |
Method for increasing cardiac mass and performance
The present invention relates to methods of using a proline/arginine-rich peptide such as PR11 or PR39 for increasing cardiac mass or performance and in the treatment of heart failure.
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US20110105948 |
Electrical Impedance Sensing Biopsy Sampling Device And Method
A biopsy sampling device has an inner trocar having a sharpened tip and a sampling opening. The trocar is slideably engaged in a central cavity of an outer needle with its sharpened tip and...
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US20110098558 |
SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND DIAGNOSIS
A method for diagnosing certain types of cancers provides a nanoparticle agent to be uptaken by cancer cells for diagnosis and treatment of certain cancers. A compound containing nanoparticles is...
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US20110091484 |
Compositions and methods for preventing or treating a viral infection
The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in...
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US20110086022 |
Methods for diagnosing and treating neuroendocrine cancer
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
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US20110079631 |
Joining Of Parts Via Magnetic Heating Of Metal-Aluminum Powders
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least...
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7919500 |
Bis-carbazole DNA intercalating agents for antitumor therapy
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, con...
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US20110076725 |
Lignin Blockers And Uses Thereof
Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment...
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7906514 |
Animal model and compounds identified via this model for treatment of chronic pain
An animal model for chronic pain, and in particular lower back pain, is provided. Methods of identifying agents and reducing chronic pain with identified agents such as methotrexate are also provided.
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7906294 |
Prognosis and treatment of breast cancer
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
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US20110041967 |
Eutectic Alloys of the Type FE 25-35 NI 15-25 MN 30-40 AL 10-20 M 0-5 and Methods for Production Thereof
Alloys, formed by a eutectic transformation of the type Fe25-35 Ni15-25 Mn30-40 Al10-20 MO-5, are disclosed. M is selected from chromium, molybdenum, carbon and combinations thereof. The alloys...
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US20110034806 |
Systems And Methods For Combined Ultrasound And Electrical Impedance Imaging
A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical...
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7883609 |
Ice modification removal and prevention
An alternating electric field is applied to ice (530) to generate a resistive AC having a frequency greater than 1000 Hz in interfacial ice at interface (554). A first electrode (510) and a second...
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7875444 |
Lignin blockers and uses thereof
Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment...
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7871776 |
Compositions and methods for enhancing the identification of prior protein PrPSc
A method for purifying PrPc, a purified preparation of PrPc and methods and kits for identifying the presence of PrPc are provided.
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7863327 |
Therapeutic compounds and methods of use
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
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US20100312305 |
Apparatus And Method For Modulating Neurochemical Levels In the Brain
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
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US20100305658 |
APPARATUS AND METHOD FOR MODULATING NEUROCHEMICAL LEVELS IN THE BRAIN
The present invention provides a method for modulating or regulating levels of a neurochemical in an individual using deep brain stimulation. More particularly, the invention relates to a method of...
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