Patents and Patent Applications from Dartmouth College


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9999617 Compositions for treating bacterial infections  
The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are...
10000598 Methods for preparation of molecularly imprinted polymers for wine extraction  
Disclosed herein are compositions of, synthesis methods and methods of use for improved molecularly imprinted polymers useful for extracting target molecule compounds of wine.
US20180161311 SYNTHETIC TRITERPENOIDS AND METHODS OF USE IN THE TREATMENT OF DISEASE  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
US20180153734 IMPLANT AND IMPLANTATION TOOL ADAPTED FOR OCCLUDING FALLOPIAN TUBES OF PLACENTAL MAMMALS  
An implantable radially-porous, polymeric, scaffold device configured for insertion into and obstruct a Fallopian tube formed of a polymer such as collagen, nanocellulose, xanthan gum, konjac...
US20180150761 EMULATION OF QUANTUM AND QUANTUM-INSPIRED SPECTRUM ANALYSIS AND SUPERPOSITION WITH CLASSICAL TRANSCONDUCTOR-CAPACITOR CIRCUITS  
We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) capacitors that represent ℏ termed...
US20180150760 EMULATION OF QUANTUM AND QUANTUM-INSPIRED DISCRETE-STATE SYSTEMS WITH CLASSICAL TRANSCONDUCTOR-CAPACITOR CIRCUITS  
We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) a real capacitor, whose value exactly...
US20180150579 EMULATION OF QUANTUM AND QUANTUM-INSPIRED DYNAMICAL SYSTEMS WITH CLASSICAL TRANSCONDUCTOR-CAPACITOR CIRCUITS  
We disclose transconductor-capacitor classical dynamical systems that emulate quantum dynamical systems and quantum-inspired systems by composing them with 1) a real capacitor, whose value exactly...
US20180147240 NKP30 RECEPTOR TARGETED THERAPEUTICS  
The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using...
US20180127379 PYRIDYL ANALOGS OF 1-(2-CYANO-3,12-DIOXOOLEANA-1,9(11)DIEN-28-OYL) IMIDAZOLE  
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided.
9964608 Method and apparatus for nonlinear susceptibility magnitude imaging of magnetic nanoparticles  
A magnetic nanoparticle imaging system has driving coils driven at multiple frequencies, the driving coils positioned to provide magnetic fields and field gradients to an imaging zone, and a...
9964433 Acoustic sensor with an acoustic object detector for reducing power consumption in front-end circuit  
An acoustic object detector for detecting presence of an acoustic signal is provided. The acoustic object detector includes a number of bandpass filters. Each bandpass filter is configured to...
US20180116985 AUTOIMMUNE DISORDER TREATMENT USING RXR AGONISTS  
The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation...
9961547 Continuous seamless mobile device authentication using a separate electronic wearable apparatus  
A technique performs a security operation. The technique includes receiving first activity data from a mobile device, the first activity data identifying activity by a user that is currently using...
9957480 T cell receptor-deficient T cell compositions  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
9954123 Multifunctional nanostructured metal-rich metal oxides  
A transparent conductive oxide (TCO) material includes a metal-rich metal oxide having an average formula (M1, M2 . . . Mn)yOx, where M1, M2 and Mn are the same metal or different metals and a...
9946973 Long-time low-latency quantum memory by dynamical decoupling  
This disclosure relates to preserving a quantum state in a quantum memory. A controller of the quantum memory determines based on a characteristic of noise that causes deterioration of the quantum...
9944692 Method for producing human monoclonal immunoglobuling antibodies  
The present invention a method for producing a human immunoglobulin G (IgG) antibody using a prime-boost regime in a Bone Marrow Liver Thymic (BLT) mouse.
9938497 T cell receptor-deficient T cell compositions  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
9936877 Wearable computing device for secure control of physiological sensors and medical devices, with secure storage of medical records, and bioimpedance biometric  
A wearable master electronic device (Amulet) has a processor with memory, the processor coupled to a body-area network (BAN) radio and uplink radio. The device has firmware for BAN communications...
9932648 Flow-through pretreatment of lignocellulosic biomass with inorganic nanoporous membranes  
A process for the pretreatment of lignocellulosic biomass is provided. The process generally includes flowing water through a pretreatment reactor containing a bed of particulate ligno-cellulosic...
US20180090537 IMAGE SENSOR AND IMAGE SENSOR PIXEL HAVING JFET SOURCE FOLLOWER  
Some embodiments provide an image sensor pixel comprising a junction field effect transistor (JFET) and a floating diffusion configured to act as the gate of the JFET. An image sensor may comprise...
US20180085400 ANTI-MICA ANTIGEN BINDING FRAGMENTS, FUSION MOLECULES, CELLS WHICH EXPRESS AND METHODS OF USING  
Antigen binding fragments, chimeric antigen receptors, and bi-specific T-cell engagers having specificity for MICA and methods for using the same in the diagnosis and treatment of disorders...
9918679 Sonification systems and methods for auditory display of physiological parameters  
Systems and methods for generating a sonification output for presenting information about physiological parameters such as oxygen saturation and heart rate parameters in discrete auditory events....
US20180070880 SYSTEMS AND METHODS FOR ENHANCING UPTAKE OF THERAPEUTIC AGENT FROM BLOODSTREAM INTO DISEASE SIT  
A method for enhancing uptake of a therapeutic agent from the bloodstream of a patient into a disease site of the patient includes applying negative pressure to the disease site to form a pressure...
US20180066059 ANTI-B7-H6 ANTIBODY, FUSION PROTEINS, AND METHODS OF USING THE SAME  
Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and treatment of disorders associated with B7-H6...
9906872 Hearing-aid noise reduction circuitry with neural feedback to improve speech comprehension  
A hearing prosthetic has microphones configured to receive audio with signal processing circuitry for reducing noise; apparatus configured to receive a signal derived from a neural interface, and...
US20180051070 Novel VISTA-Ig constructs and the use of VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders  
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig),...
9896475 Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole  
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a tnterpenoid compound of...
9896460 Molecular switches based on cis/trans isomerization of BF2-coordinated azo compounds  
Provided herein are photochromic organic compounds of Formula I or Formula II, which are useful as molecular switches capable of being triggered via a cis/trans isomerization process. Methods of...
US20180047769 GATELESS RESET FOR IMAGE SENSOR PIXELS  
Some embodiments of the present disclosure are directed to an image sensor pixel that is configured for gateless reset of a floating diffusion. Some embodiments are directed to an image sensor...
9890215 Vista modulators for diagnosis and treatment of cancer  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...
US20180029990 COMPOSITION AND METHOD FOR PREVENTION, MITIGATION OR TREATMENT OF AN ENTEROPATHOGENIC BACTERIAL INFECTION  
Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
9880118 Planar Probe and system for measuring dielectric properties of biological materials  
A probe sensor has a printed circuit comprising a coplanar transmission line, a ground plane, a plated-through contact via, and a part-circular ring of ground vias surrounding the contact via. The...
US20180023100 INCREASED ETHANOL PRODUCTION BY THERMOPHILIC MICROORGANISMS WITH DELETION OF INDIVIDUAL HFS HYDROGENASE SUBUNITS  
Disclosed are methods for engineering bacteria, for example, Thermoanaerobacterium saccharolyticum, that convert biomass to ethanol at high yield by deleting a single gene. Deletion of subunit A...
9873705 Vinylogous thioester compounds and methods of use  
Provided herein are vinylogous thioester compounds and methods for using the compounds.
US20180013970 IMAGE SENSOR WITH CONTROLLABLE NON-LINEARITY  
The present disclosure relates generally to apparatus and methods for image sensing, and, more particularly, to a multi-bit quanta image sensor (QIS) having a controllable (e.g., adjustably...
US20180009896 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND USE IN THERAPY  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
US20180008709 METHODS AND COMPOSITIONS FOR INCREASING SUSCEPTIBILITY TO RADIATION TREATMENT BY INHIBITING SUPPRESSION OF NUMERICAL CHROMOSOMAL INSTABILITY OF CANCER CELLS  
Disclosed is a method for increasing susceptibility of cancer cells to ionizing radiation by delivering to the cells a radiosensitizing agent that has one of the following properties: (a) it...
US20180006079 MULTI-JUNCTION PIXEL IMAGE SENSOR WITH DIELECTRIC REFLECTOR BETWEEN PHOTODETECTION LAYERS  
Some embodiments provide a color image sensor and color image sampling method that uses multiple-layer pixels and is capable of producing color images without using absorption color filters (e.g.,...
9856478 Method for selectively inhibiting ACAT1 in the treatment of obesity, metabolic syndrome, and atherosclerosis  
The present invention features methods for preventing and treating three related diseases, diet-induced obesity, metabolic syndrome, and atherosclerosis, alone or in combination by inhibiting...
9833476 NKP30 receptor targeted therapeutics  
The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using...
9832206 System, method and authorization device for biometric access control to digital devices  
A system and method for authenticating and continuously verifying authorized users of a digital device includes an authentication device attached to an arm or wrist of authorized users. The...
US20170334990 VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING AGENTS AND USE THEREOF  
The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct,...
9822340 T-cell receptor-deficient T cell compositions  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
9821011 T-cell receptor-deficient T cell compositions  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20170317269 POROUS PIEZOELECTRIC MATERIAL WITH DENSE SURFACE, AND ASSOCIATED METHODS AND DEVICES  
A method for producing a porous piezoelectric polymer film with a dense surface, includes depositing a polymer solution onto a substrate to form a polymer film including a solvent; evaporating a...
9803221 Engineering microorganisms to increase ethanol production by metabolic redirection  
The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting...
US20170306024 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF  
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's...
US20170306020 ANTI-HUMAN VISTA ANTIBODIES AND USE THEREOF  
The invention provides agonistic anti-human VISTA antibodies and antibody fragments. These agonist antibodies and antibody fragments may be used to potentiate or enhance or mimic VISTA's...
US20170304392 DAB2 INHIBITORS FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS  
Compositions and kits including an agent that inhibits the interaction between Disabled-2 and mutant CFTR proteins, optionally in combination with a CFTR corrector, CFTR potentiator, CAL...