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Patents and Patent Applications from Dartmouth College


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US20130041016 Compositions and Methods for Preventing and Treating Cancer via Modulating UBE1L, ISG215 and/or UBP43  
Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer...
US20130040399 Airborne Contaminant Sensor Device and Method for Using the Same  
The present invention is a nanotechnology-based personal sensor device composed of molecularly imprinted polymers that are interrogated using radio frequency identification (RFID) technology for...
US20130040327 Methods for Identifying Allosteric and Other Novel Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitors  
The present invention is a method for identifying compounds that are allosteric and/or other novel ACAT inhibitors that is based on the novel finding that pregnenolone is a substrate for ACAT;...
US20130035357 Compositions and Methods for Preventing Joint Destruction in Osteoarthritis  
The present invention is methods for inhibiting collagen destruction in joints of osteoarthritis patients. The methods are based on use of rexinoid compounds, in particular bexarotene, and their...
8368421 Micromagnetic elements, logic devices and related methods  
Micromagnetic elements, logic devices and methods of fabricating and using them to store data and perform logic operations are disclosed. Micromagnetic elements for data storage, as well as those...
US20130023439 Method and Kit for Determining Sensitivity to Decitabine Treatment  
The present invention is a gene expression panel of chemotherapeutic drug-resistant cancer stem cells comprising RIN1, SOX15 and TLR4. In one embodiment the cancer stem cells are testicular cancer...
8357667 Compositions and methods for treating pancreatic cancer  
The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA...
US20130017252 Method for Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
8348936 Thermal treatment systems with acoustic monitoring, and associated methods  
A thermal treatment system with acoustic monitoring applies substantially constant electromagnetic energy superposed with pulsed electromagnetic energy to targeted tissue. The pulsed...
US20130005747 METHOD FOR SELECTING A CANCER THERAPY  
The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of...
US20120327075 SYSTEM FOR RAPID AND ACCURATE QUANTITATIVE ASSESSMENT OF TRAUMATIC BRAIN INJURY  
A system and method for automatic segmentation, performed by selecting a deformable model of an anatomical structure of interest imaged in a volumetric image, the deformable model formed of a...
8341424 Methods for playing protected content  
One aspect of the present invention is a method of playing multi-media content through a personal computer. The personal computer includes a processor and memory, with the memory having software...
US20120321667 T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20120315493 JOINING OF PARTS VIA MAGNETIC HEATING OF METAL ALUMINUM POWDERS  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase magnetic metal-aluminum powder at an interface between the at least two parts to be...
8329197 Ex vivo uses of immunostimulatory combinations  
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
US20120302581 Methods and Compositions for the Treatment of RAS Associated Disorders  
The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example,...
US20120302466 T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20120301457 LIPID COFACTORS FOR FACILITATING PROPOGATION OF PRPsc  
The present invention embraces methods and kits for facilitating the propogation of PrPSc, and use of the same in increasing the sensitivity diagnostic assays and in identifying compounds that...
US20120295306 Modified CIPA Gene From Clostridium Thermocellum for Enhanced Genetic Stability  
Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic...
US20120294857 Monomeric Bi-Specific Fusion Protein  
The present invention embraces a bi-specific fusion protein composed of an effector cell-specific antibody-variable region fragment operably linked to at least a portion of a natural killer cell...
8314137 Monocyclic cyanoenones and methods of use thereof  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
US20120281947 System And Method For Coupling A Multi-Mode Optical Fiber To A Single Mode Optical Fiber  
A multi-mode to single mode optical interface device includes an optically pumped edge emitting semiconductor laser device and a lens. The optically pumped edge emitting semiconductor laser device...
8304401 Compositions and methods for decreasing type III deiodinase activity to modulate adiposity and blood glucose levels  
The present invention features methods for decreasing fat mass, increasing energy expenditure, increasing resistance to obesity, and lowering blood glucose levels in a subject with an agent that...
US20120277163 MicroRNA-10 Antagonists and MicroRNA-10 Targets for Use in the Treatment of a Glioma  
The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in...
US20120274325 Imaging By Magnetic Resonance Adsorption, Elastography And Tomography  
A microwave imaging system provides superior breast imaging resolution by combining MR microwave absorption and MR-compatible microwave tomography calculations. These techniques may also be...
8299046 Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth  
The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids...
8293224 Attenuated uracil auxotroph of an apicomplexan and use thereof  
Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express...
8283113 Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG15 and/or UBP43  
Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer...
8282942 Toxoplasma gondii vaccines and uses thereof  
The present invention provides attenuated Toxoplasma gondii knockout mutants of the de novo pyrimidine synthesis pathway and use of the same in vaccines and methods of providing an immune response...
US20120252192 METHOD OF GROWING HETEROEPITAXIAL SINGLE CRYSTAL OR LARGE GRAINED SEMICONDUCTOR FILMS ON GLASS SUBSTRATES AND DEVICES THEREON  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
US20120251463 Nicotinamide Riboside Kinase Compositions and Methods for Using the Same  
The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods...
8278107 Compositions and methods for regulating RNA translation via CD154 CA-dinucleotide repeat  
Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of hnRNP L with the CA-dinucleotide rich sequence of the 3′-untranslated region of CD154.
8273701 Method for diagnosing non-small cell lung carcinoma  
The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of...
US20120238623 Inflammation and Autoimmune Disorder Treatment using RARa Selective Agonists  
The present specification provides compounds, compositions and methods using such compounds and compositions to treat an autoimmune disorder, inflammation and/or a transplant rejection.
US20120234816 Systems And Methods For Windshield Deicing  
Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage...
US20120220055 Method for Detecting Cardiac Ischemia via Changes in B-Natriuretic Peptide Levels  
The present invention relates to a method of detecting cardiac ischemia by measuring the levels of BNP or NTproBNP. Increases in BNP or NTproBNP levels in an individual are indicative of cardiac...
8252914 Chimeric NK receptor and methods for treating cancer  
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
US20120215093 SYSTEM AND METHOD FOR PROVIDING PATIENT REGISTRATION WITHOUT FIDUCIALS  
A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a...
US20120214732 Inhibitors of the Trypsin-Like Site of the Proteasome and Methods of Use Thereof  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an...
US20120209347 Apparatus And Method For Modulating Neurochemical Levels In the Brain  
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
8236304 Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate CD4+ and CD8+ T cell immunity  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A...
8231872 Regulatory T cell mediator proteins and uses thereof  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A...
8228959 Free electron laser, and associated components and methods  
A system generates FIR laser radiation. An electron source generates an electron beam. A grating horn interacts with the electron beam to produce the FIR laser radiation. The grating horn may...
US20120178892 Angular Extrusion For Polymer Consolidation  
Angular extrusion (AE) methods for creating monolithic polymers with high entanglement density, but small crystallite size, are disclosed. The methods involve consolidating granular polymer in an...
US20120165365 Compositions and Methods for Treating Cancer  
The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and...
US20120164270 Yeast Strain and Method for Using the Same to Produce Nicotinamide Riboside  
The present invention embraces a fungal strain deficient in nicotinamide riboside import and salvage and use thereof for producing nicotinamide riboside. Methods for producing nicotinamide...
8207733 Imaging by magnetic resonance adsorption, elastography and tomography  
A microwave imaging system provides superior breast imaging resolution by combining MR microwave absorption and MR-compatible microwave tomography calculations. These techniques may also be...
8207325 MicroRNA biomarkers for human breast and lung cancer  
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
US20120157529 Composition and Method for Prevention, Mitigation or Treatment of an Enteropathogenic Bacterial Infection  
The present invention embraces the use of palmitoleic acid, or a derivative, mimetic, or extract containing the same, to decrease the expression of bacterial virulence factors thereby preventing,...
US20120156697 Method for Identifying an Agent that Inhibits Candida albicans-Mediated Host Cell Differentiation  
The present invention features a method for identifying an agent that inhibits Candida albicans-mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention...