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Patents and Patent Applications from Dartmouth College


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US20120115157 Methods for Screening for Antibiotic Compounds  
The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
8174253 Systems and methods that detect changes in incident optical radiation  
Systems, methods and sensors detect changes in incident optical radiation. Voltage is applied across one or more active areas of a detector while the incident optical radiation illuminates the...
8172126 Joining of parts via magnetic heating of metal-aluminum powders  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least...
US20120094950 Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis  
The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
US20120090740 Nanostructured Mn-Al Permanent Magnets And Methods Of Producing Same  
Nanostructured Mn—Al, Mn—Al—C permanent magnets are disclosed. The magnets have high coercivities (about 4.8 kOe and 5.2 kOe) and high magnetization values. An intennetallic composition inclu...
8153597 Modulators of the ABC transporter family and methods for their use  
An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and...
US20120077867 Compositions And Methods For Treating Pancreatic Cancer  
The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA...
US20120071396 Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8138227 Method for inhibiting or reversing non-enzymatic glycation  
The present invention relates to a method for inhibiting or reversing non-enzymatic glycation of the first intermediate of a biological moiety using an α-thiolamine. By inhibiting or reversing ...
US20120060232 Caveolin 1-Reporter Protein Knock-In Mouse  
The present invention embraces a transgenic mouse whose genome harbors a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter. To control expression of the Cav1-reporter, the...
8129429 Synthetic triterpenoids and methods of use in the treatment of disease  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
8124371 Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation  
The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for...
US20120045785 Hybrid Prokaryotic-Eukaryotic Tubulins and Use Thereof  
The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.
US20120045477 Method for Treating Cancer with Toxoplasma Gondii Vaccine  
The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.
US20120041315 Fluorescence Lifetime Spectrometer (FLS) and Methods of Detecting Diseased Tissue  
This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition...
US20120040304 System And Method For Post-Exposure Dosimetry Using Electron Paramagnetic Resonance Spectroscopy  
An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. When operating in...
8114626 Yeast strain and method for using the same to produce nicotinamide riboside  
The present invention embraces a fungal strain deficient in nicotinamide riboside import and salvage and use thereof for producing nicotinamide riboside. Methods for producing nicotinamide riboside...
US20120029063 CHIMERIC NK RECEPTOR AND METHODS FOR TREATING CANCER  
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
8106028 MicroRNA-21 antagonists and its target PDCD4 for use in the treatment of a glioma  
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
US20120022097 Compositions and Methods for Treating Cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
US20120021415 Methods for Determining Response to Neoadjuvant Therapy and Survival Using MicroRNA-10b  
The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression...
8101024 Removal of minerals from cellulosic biomass  
Disclosed is a method for removing minerals from a cellulosic biomass. For example, the biomass may be prewashed with an acid solution and rinsed with water to remove minerals prior to acid...
8097249 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate D4+ and CD8+ T cell immunity
 
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
US20120003114 Nanostructured Mn-Al Permanent Magnets And Methods of Producing Same  
A bulky consolidated nanostructured manganese aluminum alloy includes at least about 80% of a magnetic τ phase and having a macroscopic composition of MnXAlYDoZ, where Do is a dopant, X ranges ...
8084217 CD161 ligand, pilar, for modulating activation and proliferation of T cells  
The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly...
8068898 Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissues  
This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition...
8067583 Method for synthesizing furanosteroids  
The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole...
8067465 Tricyclic-bis-enone derivatives and methods of use thereof  
Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's...
8067394 Synthesis and biological activities of new tricyclic-bis-enones (TBEs)  
This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The...
US20110287499 Nucleic Acid Molecules Conferring Enhanced Ethanol Tolerance And Microorganisms Having Enhanced Tolerance To Ethanol  
The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol....
US20110278417 System And Methods For Smoothly Inverting One Or More Faces Of A Cubical Device  
A system and method for inverting a cubical device 100 that inverts one or more faces of the cubical device 100 in a single fluid motion. In an embodiment, the cube faces are split in two face...
US20110259880 MECHANICAL SCRAPER SYSTEM WITH SYNCHRONIZED PULSE ELECTROTHERMAL DEICING  
A mechanical scraper with synchronized pulse electrothermal deicing includes a heating element that is coupled to a power supply and that is operable to convert power from the power supply into...
US20110256601 MODIFICATION OF HYDROGENASE ACTIVITIES IN THERMOPHILIC BACTERIA TO ENHANCE ETHANOL PRODUCTION  
Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced...
8034955 Therapeutic compounds and methods of use  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
US20110244539 Selection Of Cellulolytic Microbes With High Growth Rates  
Methods for obtaining cellulolytic microbes with high growth rates are disclosed. For example, C. thermocellum colonies with growth rates higher than 0.17 hr″ 1 have been obtained by the present m...
8030446 Mutant proline-and-arginine rich peptides and methods for using the same  
The present invention relates to mutant proline-and-arginine rich (PR) peptides with defined structural characteristics for use in inhibiting mammalian 20S proteasome activity and modulating...
US20110237656 Method of Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
US20110201544 Compositions and Methods for Inhibiting the Interaction between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8000775 Systems and methods for tomographic image reconstruction  
Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the...
US20110196007 MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
7994298 Chimeric NK receptor and methods for treating cancer  
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
7993659 TLR9 agonist and CD40 agonist immunostimulatory combinations  
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
US20110190156 MOLECULAR SIGNATURES FOR DIAGNOSING SCLERODERMA  
The present invention features methods for classifying, determining severity, and predicting clinical endpoints of scleroderma based upon the expression of selected biomarker genes.
US20110187100 System and Method for Providing Knot Tying  
A knot tying system is presented containing a feeding mechanism, a knot tying device, and a clamp. The feeding mechanism has a drive roller and an idle roller capable of guiding a wire. A truck is...
7981058 Intelligent wearable monitor systems and methods  
An intelligent wearable monitoring system includes a wireless personal area network for extended monitoring of a patient's motor functions. The wireless personal area network includes an...
US20110159010 Compositions and Methods for Decreasing Type III Deiodinase Activity to Modulate Adiposity and Blood Glucose Levels  
The present invention features methods for decreasing fat mass, increasing energy expenditure, increasing resistance to obesity, and lowering blood glucose levels in a subject with an agent that...
US20110158911 Methods for Screening for Antibiotic Compounds  
The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
US20110153254 System And Method For Calibration For Image-Guided Surgery  
A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method comprising applying a transformation...
US20110152358 Compositions and Methods for Diagnosis and Treatment of Pancreatic Ductal Cancer  
The present invention includes compositions and methods for diagnosing and treating pancreatic cancer. These compositions and methods are based on the finding that 14-3-3σ protein is secreted from ...
US20110150876 Prognosis and Treatment of Breast Cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...