Patents and Patent Applications from Dartmouth College


Match Document Document Title
US20140308340 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES  
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such...
US20140300490 WEARABLE COMPUTING DEVICE FOR SECURE CONTROL OF PHYSIOLOGICAL SENSORS AND MEDICAL DEVICES, WITH SECURE STORAGE OF MEDICAL RECORDS, AND BIOIMPEDANCE BIOMETRIC  
A wearable master electronic device (Amulet) has a processor with memory, the processor coupled to a body-area network (BAN) radio and uplink radio. The device has firmware for BAN communications...
US20140299047 METHOD OF GROWING HETEROEPITAXIAL SINGLE CRYSTAL OR LARGE GRAINED SEMICONDUCTOR FILMS ON GLASS SUBSTRATES AND DEVICES THEREON  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
8853183 Prognosis and treatment of breast cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
8852597 Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity,...
US20140286821 FE-NI-MN-AL-CR ALLOYS AND METHODS FOR PRODUCTION THEREOF  
Alloys including iron, nickel, manganese, aluminum and chromium are disclosed. The alloys have high strength and ductility. The alloys are prepared from readily available transition metals, and...
US20140276230 POROELASTIC DYNAMIC MECHANICAL ANALYZER FOR DETERMINING MECHANICAL PROPERTIES OF BIOLOGICAL MATERIALS.  
A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a...
US20140275618 THERAPEUTIC COMPOUNDS AND METHODS OF USE  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
US20140269198 Beamforming Sensor Nodes And Associated Systems  
A beamforming sensor node has an array of pressure wave sensors and beamforming circuitry. Each pressure wave sensor is configured within a unique processing channel including a time delay circuit...
US20140242237 Molecularly Imprinted Polymer For Wine Extraction  
Disclosed herein are compositions of, and methods of use for, molecularly imprinted polymers useful for extracting and/or detecting target molecule compounds of wine.
US20140240074 Systems And Methods For Making Radially Anisotropic Thin-Film Magnetic Torroidal Cores, And Radially Anisotropic Cores Having Radial Anisotropy, And Inductors Having Radially Anisotropic Cores  
A radially anisotropic toroidal magnetic core is fabricated by a method including providing apparatus having a first magnet for providing a radial magnetic field extending across a cavity from an...
8816094 Hydrothiolation of unactivated alkenes  
The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.
US20140228392 COMPOSITIONS AND METHODS FOR TREATING CANCER  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
US20140227795 Molecularly Imprinted Polymers For Detection Of Contaminants  
This disclosure relates to the field of molecularly imprinted polymers for detecting target molecules.
8802646 Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
US20140220706 Molecularly Imprinted Polymer for Detecting Waterborne Target Molecules and Improving Water Quality  
This disclosure relates to the field of molecularly imprinted polymers for detecting or removing target molecules.
US20140220114 METHODS FOR TREATING NIEMANN-PICK TYPE C DISEASE  
The present invention includes methods for treating Niemann-Pick Type C disease through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are...
US20140220012 Novel VISTA-Ig constructs and the use of VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders  
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig),...
US20140219926 Biodegradable Iron Oxide Nanoparticle Gel for Tumor Bed Therapy  
A biodegradable iron oxide nanoparticle gel for hyperthermia treatment of cancer includes a polysaccharide-based carrier matrix and starch-coated iron oxide nanoparticles. The gel has sufficient...
8799754 Verification of data stream computations using third-party-supplied annotations  
A third party that performs data stream computation is requested to return not only the solution to the computation, but also “annotations” to the original data stream. The annotations are then...
8778990 Betulinic acid derivatives and methods of use thereof  
This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as...
8778903 MicroRNA-10 antagonists and MicroRNA-10 targets for use in the treatment of a glioma  
The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in...
8765781 Bis-carbazole DNA intercalating agents for antitumor therapy  
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an antitumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing...
8760135 High-efficiency base-driver circuit for power bipolar junction transistors  
A system or module has a 3-or-more layer current-controlled switching device, such as a bipolar power transistor, for driving a load and a base driver circuit coupled to drive it. The driver has a...
US20140170210 METHODS FOR TREATING IMMUNOSUPPRESSION  
The present invention includes methods for increasing white blood cell counts through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are...
8753029 System and methods for smoothly inverting one or more faces of a cubical device  
A system and method for inverting a cubical device 100 that inverts one or more faces of the cubical device 100 in a single fluid motion. In an embodiment, the cube faces are split in two face...
US20140158020 Ice-Tempered Hybrid Materials  
A metal-polymer composite scaffold includes metal particles coupled with polymer binder, the scaffold having regions of aligned porosity with a gradient. In a particular embodiment, the metal...
US20140154666 Erythrocyte Preservation Method  
A method for preserving erythrocytes comprising the steps of obtaining an erythrocyte concentrate; subjecting the erythrocyte concentrate to a gas system that includes 65% to 100% by volume and...
8741307 Hybrid prokaryotic-eukaryotic tubulins and use thereof  
The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.
US20140147838 METHOD FOR MULTICOLOR CODETECTION OF MICRORNA AND PROTEINS  
The present invention is directed to systems and methods of conducting a purchase transaction of eligible goods or services using a stored value associated with an indicia. Methods in accordance...
US20140141122 CONVERSION OF SOYBEAN HULLS TO ETHANOL AND HIGH-PROTEIN FOOD ADDITIVES  
Soybean hull fermentation methods that produce food additives having a high protein content are disclosed. The protein is generally present as unhydrolyzed and non-racemized protein that possesses...
US20140114150 Method And System For Using Cherenkov Radiation To Monitor Beam Profiles And Radiation Therapy  
A system for providing monitored radiation therapy has a high energy radiation source, apparatus for excluding uncontrolled ambient light, and apparatus for collecting light emitted from a...
US20140105912 VISTA MODULATORS FOR DIAGNOSIS AND TREATMENT OF CANCER  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...
8697668 Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG215 and/or UBP43  
Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer...
US20140100155 COMBINATION THERAPY AND KIT FOR THE PREVENTION AND TREATMENT OF CYSTIC FIBROSIS  
A combination therapy and kit including an agent that inhibit the interaction between CAL and mutant CFTR proteins, in combination with a CFTR corrector, CFTR potentiator, mucolytic,...
8679501 Method for modulating inflammatory responses  
The present invention is a method for inhibiting Treg cell functional activities by blocking Treg cell-mediated mast cell activation. It has been found IL-9 produced by Treg cells activates mast...
8673874 Methods for treating pancreatic cancer  
The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA...
8673587 Methods for identifying allosteric and other novel acyl-coenzyme A:cholesterol acyltransferase inhibitors  
The present invention is a method for identifying compounds that are allosteric and/or other novel ACAT inhibitors that is based on the novel finding that pregnenolone is a substrate for ACAT;...
8673289 Attenuated uracil auxotroph of an apicomplexan and use thereof  
Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express...
US20140066324 GENE EXPRESSION SIGNATURE IN SKIN PREDICTS RESPONSE TO MYCOPHENOLATE MOFETIL  
Described herein are methods and compositions for identifying patients with SSc or scleroderma who are responders to MMF treatment.
8666207 System and method for coupling a multi-mode optical fiber to a single mode optical fiber  
A multi-mode to single mode optical interface device includes an optically pumped edge emitting semiconductor laser device and a lens. The optically pumped edge emitting semiconductor laser device...
US20140056892 VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders  
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig)....
US20140056498 SYSTEM AND METHOD FOR REGISTERING ULTRASOUND AND MAGNETIC RESONANCE IMAGES  
A system and methods are presented for emulating the appearance of prominent features captured in ultrasound through directional dilation of a magnetic resonance gradient image along a direction...
8658601 Peptides and nanoparticles for therapeutic and diagnostic applications  
Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
US20140050730 METHODS FOR DIAGNOSING AND TREATING NEUROENDOCRINE CANCER  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
8655438 Electroencephalography monitoring device having a self-adaptive analog-to-digital converter  
An EEG monitoring device, contains at least one electrode, a non-linear analog signal processor, a variable resolution analog-to-digital converter, a storage, and a power source. The non-linear...
US20140044757 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF ALZHEIMER'S DISEASE  
The present invention features methods for stimulating clearance of amyloid beta in microglia, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
US20140044333 SYSTEM AND METHOD FOR PROVIDING REGISTRATION BETWEEN BREAST SHAPES BEFORE AND DURING SURGERY  
A registration framework is presented that registers volumetric breast images captured before surgery with intraoperative surface images. The framework may be implemented using either image-based...
8642723 Angular extrusion for polymer consolidation  
Angular extrusion (AE) methods for creating monolithic polymers with high crystallinity, but small crystallite size, are disclosed. The methods involve consolidating granular polymer in an...
US20140030807 METHOD FOR STIMULATING FOXP3+ REGULATORY T CELL EXPRESSION OF CD39  
Disclosed is the use of isolated Bacteroides fragilis capsular polysaccharide A in a method for stimulating FoxP3+ regulatory T cell expression of CD39.