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Patents and Patent Applications from Dartmouth College


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US20120252192 METHOD OF GROWING HETEROEPITAXIAL SINGLE CRYSTAL OR LARGE GRAINED SEMICONDUCTOR FILMS ON GLASS SUBSTRATES AND DEVICES THEREON  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
US20120251463 Nicotinamide Riboside Kinase Compositions and Methods for Using the Same  
The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods...
8278107 Compositions and methods for regulating RNA translation via CD154 CA-dinucleotide repeat  
Compositions and methods for regulating CD154 gene expression are provided that rely on the interaction of hnRNP L with the CA-dinucleotide rich sequence of the 3′-untranslated region of CD154.
8273701 Method for diagnosing non-small cell lung carcinoma  
The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of...
US20120238623 Inflammation and Autoimmune Disorder Treatment using RARa Selective Agonists  
The present specification provides compounds, compositions and methods using such compounds and compositions to treat an autoimmune disorder, inflammation and/or a transplant rejection.
US20120234816 Systems And Methods For Windshield Deicing  
Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage high...
US20120220055 Method for Detecting Cardiac Ischemia via Changes in B-Natriuretic Peptide Levels  
The present invention relates to a method of detecting cardiac ischemia by measuring the levels of BNP or NTproBNP. Increases in BNP or NTproBNP levels in an individual are indicative of cardiac...
8252914 Chimeric NK receptor and methods for treating cancer  
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
US20120215093 SYSTEM AND METHOD FOR PROVIDING PATIENT REGISTRATION WITHOUT FIDUCIALS  
A method for providing patient registration without fiducials comprises the steps of: spatially placing an ultrasound image of a patient randomly at different starting positions relative to a...
US20120214732 Inhibitors of the Trypsin-Like Site of the Proteasome and Methods of Use Thereof  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an a...
US20120209347 Apparatus And Method For Modulating Neurochemical Levels In the Brain  
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
8236304 Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate CD4+ and CD8+ T cell immunity  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
8231872 Regulatory T cell mediator proteins and uses thereof  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
8228959 Free electron laser, and associated components and methods  
A system generates FIR laser radiation. An electron source generates an electron beam. A grating horn interacts with the electron beam to produce the FIR laser radiation. The grating horn may...
US20120178892 Angular Extrusion For Polymer Consolidation  
Angular extrusion (AE) methods for creating monolithic polymers with high entanglement density, but small crystallite size, are disclosed. The methods involve consolidating granular polymer in an...
US20120165365 Compositions and Methods for Treating Cancer  
The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and glial...
US20120164270 Yeast Strain and Method for Using the Same to Produce Nicotinamide Riboside  
The present invention embraces a fungal strain deficient in nicotinamide riboside import and salvage and use thereof for producing nicotinamide riboside. Methods for producing nicotinamide riboside...
8207733 Imaging by magnetic resonance adsorption, elastography and tomography  
A microwave imaging system provides superior breast imaging resolution by combining MR microwave absorption and MR-compatible microwave tomography calculations. These techniques may also be...
8207325 MicroRNA biomarkers for human breast and lung cancer  
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
US20120157529 Composition and Method for Prevention, Mitigation or Treatment of an Enteropathogenic Bacterial Infection  
The present invention embraces the use of palmitoleic acid, or a derivative, mimetic, or extract containing the same, to decrease the expression of bacterial virulence factors thereby preventing,...
US20120156697 Method for Identifying an Agent that Inhibits Candida albicans-Mediated Host Cell Differentiation  
The present invention features a method for identifying an agent that inhibits Candida albicans-mediated differentiation of keratinocytes. Agents identified by the screening assay of the invention...
US20120156312 Compositions for Inhibiting Growth of Cancer Stem Cells  
The present invention is a biomarker of chemotherapeutic drug-resistant cancer stem cells and a method of inhibiting the growth of drug-resistant cancer stem cells. In one embodiment the cancer...
8197807 Nicotinamide riboside kinase compositions and methods for using the same  
The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods...
8193392 Method for enantioselective synthesis of phosphorus-stereogenic phosphines  
The present invention relates to a process for preparing an enantioenriched phosphorus-stereogenic, tertiary phosphine. Secondary phosphines are contacted with an alkyl halide and base in the...
US20120122877 Compositions for Treating Bacterial Infections  
The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are...
US20120115157 Methods for Screening for Antibiotic Compounds  
The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
8174253 Systems and methods that detect changes in incident optical radiation  
Systems, methods and sensors detect changes in incident optical radiation. Voltage is applied across one or more active areas of a detector while the incident optical radiation illuminates the...
8172126 Joining of parts via magnetic heating of metal-aluminum powders  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least...
US20120094950 Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis  
The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
US20120090740 Nanostructured Mn-Al Permanent Magnets And Methods Of Producing Same  
Nanostructured Mn—Al, Mn—Al—C permanent magnets are disclosed. The magnets have high coercivities (about 4.8 kOe and 5.2 kOe) and high magnetization values. An intennetallic composition inclu...
8153597 Modulators of the ABC transporter family and methods for their use  
An isolated factor derived from the bacterium Pseudomonas aeruginosa and confirmed by proteomics to be a protein that reduces expression of ABC transmembrane proteins and active fragments and...
US20120077867 Compositions And Methods For Treating Pancreatic Cancer  
The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA...
US20120071396 Compositions and Methods for Inhibiting the Interaction Between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8138227 Method for inhibiting or reversing non-enzymatic glycation  
The present invention relates to a method for inhibiting or reversing non-enzymatic glycation of the first intermediate of a biological moiety using an α-thiolamine. By inhibiting or reversing ...
US20120060232 Caveolin 1-Reporter Protein Knock-In Mouse  
The present invention embraces a transgenic mouse whose genome harbors a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter. To control expression of the Cav1-reporter, the...
8129429 Synthetic triterpenoids and methods of use in the treatment of disease  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
8124371 Compositions and methods for destabilizing lysosomes to increase oncogenic or aberrant protein degradation  
The present invention relates to compositions for destabilizing lysosomes to increase the degradation of oncogenic or aberrant proteins for the prevention or treatment of disease. Methods for...
US20120045785 Hybrid Prokaryotic-Eukaryotic Tubulins and Use Thereof  
The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.
US20120045477 Method for Treating Cancer with Toxoplasma Gondii Vaccine  
The present invention provides attenuated Toxoplasma gondii mutants for use as vaccines in the prevention or treatment of cancer.
US20120041315 Fluorescence Lifetime Spectrometer (FLS) and Methods of Detecting Diseased Tissue  
This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition...
US20120040304 System And Method For Post-Exposure Dosimetry Using Electron Paramagnetic Resonance Spectroscopy  
An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. When operating in...
8114626 Yeast strain and method for using the same to produce nicotinamide riboside  
The present invention embraces a fungal strain deficient in nicotinamide riboside import and salvage and use thereof for producing nicotinamide riboside. Methods for producing nicotinamide riboside...
US20120029063 CHIMERIC NK RECEPTOR AND METHODS FOR TREATING CANCER  
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
8106028 MicroRNA-21 antagonists and its target PDCD4 for use in the treatment of a glioma  
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
US20120022097 Compositions and Methods for Treating Cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
US20120021415 Methods for Determining Response to Neoadjuvant Therapy and Survival Using MicroRNA-10b  
The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression...
8101024 Removal of minerals from cellulosic biomass  
Disclosed is a method for removing minerals from a cellulosic biomass. For example, the biomass may be prewashed with an acid solution and rinsed with water to remove minerals prior to acid...
8097249 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate D4+ and CD8+ T cell immunity
 
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
US20120003114 Nanostructured Mn-Al Permanent Magnets And Methods of Producing Same  
A bulky consolidated nanostructured manganese aluminum alloy includes at least about 80% of a magnetic τ phase and having a macroscopic composition of MnXAlYDoZ, where Do is a dopant, X ranges ...
8084217 CD161 ligand, pilar, for modulating activation and proliferation of T cells  
The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly...