Patents and Patent Applications from Dartmouth College


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US20150196517 Autoimmune Disorder Treatment Using RXR Agonists  
The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation...
9078904 Methods for increasing plasmin activity and promoting plaque regression in the treatment of atherosclerosis  
The present invention provides the use of recombinant plasminogen activator inhibitor-1 (PAI-1) isoform 23 in methods of increasing plasmin activity, inhibiting angiogenic vasa vasorum, promoting...
US20150190484 METHODS FOR REDUCING CELLULAR SENESCENCE MEDIATED BY DNA DAMAGING AGENTS  
A method for reducing cellular senescence in a subject, in particular a subject exposed to or at risk of being exposed to a DNA damaging agents, e.g., radiation, by inhibiting PAI-1 activity in...
US20150174163 METHODS FOR IDENTIFYING AND INHIBITING GROWTH OF CHEMOTHERAPEUTIC-RESISTANT CANCERS  
The present invention is a biomarker of chemotherapeutic drug-resistant cancer stem cells and a method of inhibiting the growth of drug-resistant cancer stem cells. In one embodiment the cancer...
US20150168372 Method And Apparatus For Quantifying Oxygen Consumption Of Mitochondria  
A system for measuring oxygen consumption uses a chamber holding culture medium with a biological material. A resistively gas-permeable membrane has a first side contacting culture medium in the...
9056135 MicroRNA biomarkers for human breast and lung cancer  
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
9052384 System and method for calibration for image-guided surgery  
A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method including applying a transformation...
9051593 Recombinant prokaryotes and use thereof for production of O-glycosylated proteins  
The present invention embraces a recombinant prokaryotic host cell containing nucleic acids encoding an eukaryotic UDP-GaINAc:UDP-GaINAc polypeptide transferase and expressing an UDP-GIcNAc C-4...
US20150152181 ANTI-B7-H6 ANTIBODY, FUSION PROTEINS, AND METHODS OF USING THE SAME  
Antibodies, chimeric antigen receptors, and bispecific T-cell engagers having specificity for B7-H6 and methods for using the same in the diagnosis and treatment of disorders associated with B7-H6...
US20150150460 Methods And Systems For Intraoperative Tumor Margin Assessment In Surgical Cavities And Resected Tissue Specimens  
A tissue classifying system uses central illumination while detecting scattered light received from one or more rings surrounding the central illumination. A broadband illuminator is used....
9045527 Small molecule conjugates with dimetal species for protein inhibition  
Methods for targeting a protein by providing an inhibitor covalently linked to a rhodium(II) complex, introducing the inhibitor to the target protein and allowing the inhibitor and protein to...
US20150148661 System And Apparatus For Porously-Encapsulated Magnetic-Nanoparticle Biosensors  
A system for measuring analyte concentrations has porous-walled nanocontainers containing multiple magnetic nanoparticles, the magnetic nanoparticles coated with a selective binder that is...
9034262 Molecularly imprinted polymer sensor systems and related methods  
A molecularly imprinted polymer (MIP) sensor including a substrate, two or more electrodes, a conductive layer applied to the substrate and a molecularly imprinted polymer layer applied to the...
US20150133749 SONIFICATION SYSTEMS AND METHODS FOR AUDITORY DISPLAY OF PHYSIOLOGICAL PARAMETERS  
Systems and methods for generating a sonification output for presenting information about physiological parameters such as oxygen saturation and heart rate parameters in discrete auditory events....
US20150132857 Systems, Sensing Devices And Methods For Detection Of Airborne Contaminants  
A device for detecting airborne contaminants includes a protonated, electrically conductive sensing material with affinity for binding with, and capable of being deprotonated by, the airborne...
9028826 Methods of immune therapy with anti-CD154 antibodies having impaired FcR binding and/or complement binding properties  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
9028812 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
T cell receptor-deficient T cell compositions
 
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20150110760 NKP30 RECEPTOR TARGETED THERAPEUTICS  
The invention is directed to T cells and other cells that express chimeric NK-p30 receptors (“chimeric NKp30 T cells”), methods of making and using chimeric NKp30 T cells, and methods of using...
US20150104429 SYNTHETIC TRITERPENOIDS AND METHODS FOR MODULATING STEM/PROGENITOR CELL GENE EXPRESSION  
Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided. Furthermore, the present invention provides methods...
US20150100218 Sudden Acceleration Shutdown Device Using Hydraulic Brake Pressure Detector To Disable Vehicle On Driver Panic  
A safety shutdown system for a vehicle has a device for detecting a panic-level force applied to a vehicle control with a first state indicative of no detected panic-level forces, and a second...
9000188 Monocyclic cyanoenones and methods of use thereof  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
8999919 Compositions and methods for inhibiting the interaction between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8999233 Nanostructured Mn-Al permanent magnets and methods of producing same  
Nanostructured Mn—Al, Mn—Al—C permanent magnets are disclosed. The magnets have high coercivities (about 4.8 kOe and 5.2 kOe) and high magnetization values. An intennetallic composition includes a...
US20150080766 Model And Apparatus For Predicting Brain Trauma From Applied Forces To The Head  
A system for evaluating head injury uses instrumented helmets to transmit accelerometer readings to a computing system configured with machine readable code to determine angle and acceleration of...
US20150079697 Devices For Detecting Airborne Contaminants, And Associated Methods  
A device for detecting an airborne contaminant includes (a) a reactive polymer film having affinity for binding with the airborne contaminant, (b) an electrically conductive polymer film in...
US20150079161 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES  
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with...
8981144 Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof  
The present invention is a method for preparing triterpenoids such as 2-cyano-3,12-dioxoolean-1,9-dien-28-methyl ester and derivatives thereof from oleanic acid, ursolic acid, betulinic acid,...
8977340 System and method for collection and use of magnetic resonance data and microwave data to identify boundaries of interest  
A system and method for detecting permittivity and conductivity boundaries within a high resolution spatial image of a material is presented. Electrical properties of a material, such as...
8975274 Compositions and methods for treating cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
US20150057326 Method for Synthesizing Cycloalkanyl[b]indoles, Cycloalkanyl[b]benzofurans, Cycloalkanyl[b]benzothiophenes, Compounds and Methods of Use  
A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that...
US20150050294 METHODS FOR DIAGNOSING AND TREATING NEUROENDOCRINE CANCER  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
US20150045389 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR  
The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in...
8954131 Magnetic particle imaging (MPI) system and method for use of iron-based nanoparticles in imaging and diagnosis  
A method for diagnosing certain types of cancers provides a nanoparticle agent to be uptaken by cancer cells for diagnosis and treatment of certain cancers. A compound containing nanoparticles is...
US20150038872 MULTIPLE-ELECTRODE ELECTRICAL IMPEDANCE SENSING BIOPSY SAMPLING DEVICE AND METHOD  
A biopsy sampling device has an inner trocar having a sampling opening, an outer needle with 4 or more electrodes on it, an impedance measuring apparatus coupled to drive current through a first...
US20150038585 Treatment of Diseases by Concurrently Eliciting Remyelination Effects and Immunomodulatory Effects Using Selective RXR Agonists  
The present specification provides RXR agonists with both remyelination promotion and immunomodulatory activities, compositions comprising such RXR agonists, and methods using such compounds and...
8948851 Method and apparatus for depth-resolved fluorescence, chromophore, and oximetry imaging for lesion identification during surgery  
A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at...
8948849 System and method for optode and electrode positioning cap for electroencephalography, diffuse optical imaging, and functional neuroimaging  
An electroencephalographic electrode and optode positioning device has the form of a cap suitable for placement on a subject's head. The cap has semirigid telescopic structures that stiffen it to...
US20150011627 TRITERPENOIDS AND COMPOSITIONS CONTAINING THE SAME  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
8921739 Systems and methods for windshield deicing  
Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage...
8921419 Triterpenoids and compositions containing the same  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
8921340 Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
US20140378843 Method And Apparatus For Quantitative Hyperspectral Fluorescence And Reflectance Imaging For Surgical Guidance  
An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output...
US20140377235 METHODS FOR USING SYNTHETIC TRITERPENOIDS IN THE TREATMENT OF BONE OR CARTILAGE DISEASES OR CONDITIONS  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
US20140375337 Planar Probe And System For Measuring Dielectric Properties Of Biological Materials  
A probe sensor has a printed circuit comprising a coplanar transmission line, a ground plane, a plated-through contact via, and a part-circular ring of ground vias surrounding the contact via. The...
8916455 Method of growing heteroepitaxial single crystal or large grained semiconductor films on glass substrates and devices thereon  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
US20140371600 Apparatus For Meausring In-Vivo Mechanical Properties of Biological Tissues  
An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired...
US20140369584 Method And Apparatus For Determining Tumor Shift During Surgery Using A Stereo-Optical Three-Dimensional Surface-Mapping System  
A system and method for determining intraoperative locations of a lesion in tissue from lesion locations determined in preoperative imaging includes determining three dimensional locations of...
US20140362186 METHOD AND APPARATUS FOR CALIBRATION OF STEREO-OPTICAL THREE-DIMENSIONAL SURFACE-MAPPING SYSTEM  
A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction...
US20140356921 Engineering Microorganisms to Increase Ethanol Production by Metabolic Redirection  
The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting...
US20140341920 VISTA MODULATORS FOR DIAGNOSIS AND TREATMENT OF CANCER  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...