Patents and Patent Applications from Dartmouth College


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9000188 Monocyclic cyanoenones and methods of use thereof  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
8999919 Compositions and methods for inhibiting the interaction between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8999233 Nanostructured Mn-Al permanent magnets and methods of producing same  
Nanostructured Mn—Al, Mn—Al—C permanent magnets are disclosed. The magnets have high coercivities (about 4.8 kOe and 5.2 kOe) and high magnetization values. An intennetallic composition includes a...
US20150080766 Model And Apparatus For Predicting Brain Trauma From Applied Forces To The Head  
A system for evaluating head injury uses instrumented helmets to transmit accelerometer readings to a computing system configured with machine readable code to determine angle and acceleration of...
US20150079697 Devices For Detecting Airborne Contaminants, And Associated Methods  
A device for detecting an airborne contaminant includes (a) a reactive polymer film having affinity for binding with the airborne contaminant, (b) an electrically conductive polymer film in...
US20150079161 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES  
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with...
8981144 Method for synthesizing 2-cyano-3,12-dioxoolean-1, 9(11)-dien-28-oic acid methyl ester and derivatives thereof  
The present invention is a method for preparing triterpenoids such as 2-cyano-3,12-dioxoolean-1,9-dien-28-methyl ester and derivatives thereof from oleanic acid, ursolic acid, betulinic acid,...
8977340 System and method for collection and use of magnetic resonance data and microwave data to identify boundaries of interest  
A system and method for detecting permittivity and conductivity boundaries within a high resolution spatial image of a material is presented. Electrical properties of a material, such as...
8975274 Compositions and methods for treating cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
US20150057326 Method for Synthesizing Cycloalkanyl[b]indoles, Cycloalkanyl[b]benzofurans, Cycloalkanyl[b]benzothiophenes, Compounds and Methods of Use  
A method of synthesizing cycloalkanyl[b]indoles, as well as related cycloalkanyl[b]benzofurans and cycloalkanyl[b]benzothiophenes is provided. The method is a single, multicomponent reaction that...
US20150050294 METHODS FOR DIAGNOSING AND TREATING NEUROENDOCRINE CANCER  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
US20150045389 COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR  
The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in...
8954131 Magnetic particle imaging (MPI) system and method for use of iron-based nanoparticles in imaging and diagnosis  
A method for diagnosing certain types of cancers provides a nanoparticle agent to be uptaken by cancer cells for diagnosis and treatment of certain cancers. A compound containing nanoparticles is...
US20150038872 MULTIPLE-ELECTRODE ELECTRICAL IMPEDANCE SENSING BIOPSY SAMPLING DEVICE AND METHOD  
A biopsy sampling device has an inner trocar having a sampling opening, an outer needle with 4 or more electrodes on it, an impedance measuring apparatus coupled to drive current through a first...
US20150038585 Treatment of Diseases by Concurrently Eliciting Remyelination Effects and Immunomodulatory Effects Using Selective RXR Agonists  
The present specification provides RXR agonists with both remyelination promotion and immunomodulatory activities, compositions comprising such RXR agonists, and methods using such compounds and...
8948851 Method and apparatus for depth-resolved fluorescence, chromophore, and oximetry imaging for lesion identification during surgery  
A tomographic fluorescent imaging device for imaging fluorophores in biological tissues has a scanned laser for scanning the tissue and a camera for receiving light from the biological tissue at...
8948849 System and method for optode and electrode positioning cap for electroencephalography, diffuse optical imaging, and functional neuroimaging  
An electroencephalographic electrode and optode positioning device has the form of a cap suitable for placement on a subject's head. The cap has semirigid telescopic structures that stiffen it to...
US20150011627 TRITERPENOIDS AND COMPOSITIONS CONTAINING THE SAME  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
8921739 Systems and methods for windshield deicing  
Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage...
8921419 Triterpenoids and compositions containing the same  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
8921340 Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
US20140378843 Method And Apparatus For Quantitative Hyperspectral Fluorescence And Reflectance Imaging For Surgical Guidance  
An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output...
US20140377235 METHODS FOR USING SYNTHETIC TRITERPENOIDS IN THE TREATMENT OF BONE OR CARTILAGE DISEASES OR CONDITIONS  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
US20140375337 Planar Probe And System For Measuring Dielectric Properties Of Biological Materials  
A probe sensor has a printed circuit comprising a coplanar transmission line, a ground plane, a plated-through contact via, and a part-circular ring of ground vias surrounding the contact via. The...
8916455 Method of growing heteroepitaxial single crystal or large grained semiconductor films on glass substrates and devices thereon  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
US20140371600 Apparatus For Meausring In-Vivo Mechanical Properties of Biological Tissues  
An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired...
US20140369584 Method And Apparatus For Determining Tumor Shift During Surgery Using A Stereo-Optical Three-Dimensional Surface-Mapping System  
A system and method for determining intraoperative locations of a lesion in tissue from lesion locations determined in preoperative imaging includes determining three dimensional locations of...
US20140362186 METHOD AND APPARATUS FOR CALIBRATION OF STEREO-OPTICAL THREE-DIMENSIONAL SURFACE-MAPPING SYSTEM  
A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction...
US20140356921 Engineering Microorganisms to Increase Ethanol Production by Metabolic Redirection  
The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting...
US20140341920 VISTA MODULATORS FOR DIAGNOSIS AND TREATMENT OF CANCER  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...
8889836 Method for non-covalent immobilization of infectious prion protein  
The present invention is method for non-covalently immobilizing an infectious prion protein using a magnetic substrate.
US20140336385 TRIAZOLIUM AND TETRAZOLIUM DERIVATIVES AS ORGANIC LIGHT EMITTERS  
Provided herein are organic compounds useful in a variety of OLED applications.
US20140331915 METHOD OF GROWING HETEROEPITAXIAL SINGLE CRYSTAL OR LARGE GRAINED SEMICONDUCTOR FILMS ON GLASS SUBSTRATES AND DEVICES THEREON  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
8886291 Systems and methods for combined ultrasound and electrical impedance imaging  
A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical...
8886284 Devices and methods for combined optical and magnetic resonance imaging  
Optical devices for use with a magnetic resonance imaging breast compression system include light wands and optical adapters that can releasably mate with grids. These devices, and their...
US20140329760 PEPTIDES AND NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS  
Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
US20140329312 METHOD FOR PRODUCING HUMAN MONOCLONAL IMMUNOGLOBULIN G ANTIBODIES  
The present invention a method for producing a human immunoglobulin G (IgG) antibody using a prime-boost regime in a Bone Marrow Liver Thymic (BLT) mouse.
US20140328809 METHODS OF INDUCING CHONDROGENESIS IN MESENCHYMAL STEM CELLS USING SYNTHETIC TRITERPENOIDS  
The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the...
US20140322783 Engineering an Increase in Ethanol Production by Altering Cofactor Specificity  
The present invention provides for the manipulation of cofactor usage in a recombinant host cell to increase the formation of desirable products. In some embodiments, the invention provides for a...
US20140321696 Perceptual Rating Of Digital Image Retouching  
A method is provided for automatically providing a digital image rating of photo retouching. The method includes the step of receiving at a computer, including a processor, a first set of pixel...
US20140308340 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES  
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such...
US20140300490 WEARABLE COMPUTING DEVICE FOR SECURE CONTROL OF PHYSIOLOGICAL SENSORS AND MEDICAL DEVICES, WITH SECURE STORAGE OF MEDICAL RECORDS, AND BIOIMPEDANCE BIOMETRIC  
A wearable master electronic device (Amulet) has a processor with memory, the processor coupled to a body-area network (BAN) radio and uplink radio. The device has firmware for BAN communications...
US20140299047 METHOD OF GROWING HETEROEPITAXIAL SINGLE CRYSTAL OR LARGE GRAINED SEMICONDUCTOR FILMS ON GLASS SUBSTRATES AND DEVICES THEREON  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
8853183 Prognosis and treatment of breast cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
8852597 Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity,...
US20140286821 FE-NI-MN-AL-CR ALLOYS AND METHODS FOR PRODUCTION THEREOF  
Alloys including iron, nickel, manganese, aluminum and chromium are disclosed. The alloys have high strength and ductility. The alloys are prepared from readily available transition metals, and...
US20140276230 POROELASTIC DYNAMIC MECHANICAL ANALYZER FOR DETERMINING MECHANICAL PROPERTIES OF BIOLOGICAL MATERIALS.  
A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a...
US20140275618 THERAPEUTIC COMPOUNDS AND METHODS OF USE  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
US20140269198 Beamforming Sensor Nodes And Associated Systems  
A beamforming sensor node has an array of pressure wave sensors and beamforming circuitry. Each pressure wave sensor is configured within a unique processing channel including a time delay circuit...
US20140242237 Molecularly Imprinted Polymer For Wine Extraction  
Disclosed herein are compositions of, and methods of use for, molecularly imprinted polymers useful for extracting and/or detecting target molecule compounds of wine.