Patents and Patent Applications from Dartmouth College


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US20150011627 TRITERPENOIDS AND COMPOSITIONS CONTAINING THE SAME  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
8921739 Systems and methods for windshield deicing  
Cost efficient, lightweight and rapid windshield deicing systems and methods are disclosed. The systems utilize step-up converters or inverters, or dual-voltage batteries, to provide a voltage...
8921419 Triterpenoids and compositions containing the same  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
8921340 Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
US20140378843 Method And Apparatus For Quantitative Hyperspectral Fluorescence And Reflectance Imaging For Surgical Guidance  
An imaging system includes an illumination device for illuminating a target. A surgical microscope receives light from the target, the surgical microscope comprising at least one optical output...
US20140377235 METHODS FOR USING SYNTHETIC TRITERPENOIDS IN THE TREATMENT OF BONE OR CARTILAGE DISEASES OR CONDITIONS  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
US20140375337 Planar Probe And System For Measuring Dielectric Properties Of Biological Materials  
A probe sensor has a printed circuit comprising a coplanar transmission line, a ground plane, a plated-through contact via, and a part-circular ring of ground vias surrounding the contact via. The...
8916455 Method of growing heteroepitaxial single crystal or large grained semiconductor films on glass substrates and devices thereon  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
US20140371600 Apparatus For Meausring In-Vivo Mechanical Properties of Biological Tissues  
An apparatus and method for measuring mechanical properties of tissue has a stereo optical surgical microscope with at least one objective lens and at least two digital cameras such that paired...
US20140369584 Method And Apparatus For Determining Tumor Shift During Surgery Using A Stereo-Optical Three-Dimensional Surface-Mapping System  
A system and method for determining intraoperative locations of a lesion in tissue from lesion locations determined in preoperative imaging includes determining three dimensional locations of...
US20140362186 METHOD AND APPARATUS FOR CALIBRATION OF STEREO-OPTICAL THREE-DIMENSIONAL SURFACE-MAPPING SYSTEM  
A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction...
US20140356921 Engineering Microorganisms to Increase Ethanol Production by Metabolic Redirection  
The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting...
US20140341920 VISTA MODULATORS FOR DIAGNOSIS AND TREATMENT OF CANCER  
The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and...
8889836 Method for non-covalent immobilization of infectious prion protein  
The present invention is method for non-covalently immobilizing an infectious prion protein using a magnetic substrate.
US20140336385 TRIAZOLIUM AND TETRAZOLIUM DERIVATIVES AS ORGANIC LIGHT EMITTERS  
Provided herein are organic compounds useful in a variety of OLED applications.
US20140331915 METHOD OF GROWING HETEROEPITAXIAL SINGLE CRYSTAL OR LARGE GRAINED SEMICONDUCTOR FILMS ON GLASS SUBSTRATES AND DEVICES THEREON  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
8886291 Systems and methods for combined ultrasound and electrical impedance imaging  
A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical...
8886284 Devices and methods for combined optical and magnetic resonance imaging  
Optical devices for use with a magnetic resonance imaging breast compression system include light wands and optical adapters that can releasably mate with grids. These devices, and their...
US20140329760 PEPTIDES AND NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS  
Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
US20140329312 METHOD FOR PRODUCING HUMAN MONOCLONAL IMMUNOGLOBULIN G ANTIBODIES  
The present invention a method for producing a human immunoglobulin G (IgG) antibody using a prime-boost regime in a Bone Marrow Liver Thymic (BLT) mouse.
US20140328809 METHODS OF INDUCING CHONDROGENESIS IN MESENCHYMAL STEM CELLS USING SYNTHETIC TRITERPENOIDS  
The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the...
US20140322783 Engineering an Increase in Ethanol Production by Altering Cofactor Specificity  
The present invention provides for the manipulation of cofactor usage in a recombinant host cell to increase the formation of desirable products. In some embodiments, the invention provides for a...
US20140321696 Perceptual Rating Of Digital Image Retouching  
A method is provided for automatically providing a digital image rating of photo retouching. The method includes the step of receiving at a computer, including a processor, a first set of pixel...
US20140308340 METHOD FOR SELECTIVELY INHIBITING ACAT1 IN THE TREATMENT OF NEURODEGENERATIVE DISEASES  
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such...
US20140300490 WEARABLE COMPUTING DEVICE FOR SECURE CONTROL OF PHYSIOLOGICAL SENSORS AND MEDICAL DEVICES, WITH SECURE STORAGE OF MEDICAL RECORDS, AND BIOIMPEDANCE BIOMETRIC  
A wearable master electronic device (Amulet) has a processor with memory, the processor coupled to a body-area network (BAN) radio and uplink radio. The device has firmware for BAN communications...
US20140299047 METHOD OF GROWING HETEROEPITAXIAL SINGLE CRYSTAL OR LARGE GRAINED SEMICONDUCTOR FILMS ON GLASS SUBSTRATES AND DEVICES THEREON  
Inexpensive semiconductors are produced by depositing a single crystal or large grained silicon on an inexpensive substrate. These semiconductors are produced at low enough temperatures such as...
8853183 Prognosis and treatment of breast cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
8852597 Anti-CD154 antibodies having impaired FcR binding and/or complement binding properties  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity,...
US20140286821 FE-NI-MN-AL-CR ALLOYS AND METHODS FOR PRODUCTION THEREOF  
Alloys including iron, nickel, manganese, aluminum and chromium are disclosed. The alloys have high strength and ductility. The alloys are prepared from readily available transition metals, and...
US20140276230 POROELASTIC DYNAMIC MECHANICAL ANALYZER FOR DETERMINING MECHANICAL PROPERTIES OF BIOLOGICAL MATERIALS.  
A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a...
US20140275618 THERAPEUTIC COMPOUNDS AND METHODS OF USE  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
US20140269198 Beamforming Sensor Nodes And Associated Systems  
A beamforming sensor node has an array of pressure wave sensors and beamforming circuitry. Each pressure wave sensor is configured within a unique processing channel including a time delay circuit...
US20140242237 Molecularly Imprinted Polymer For Wine Extraction  
Disclosed herein are compositions of, and methods of use for, molecularly imprinted polymers useful for extracting and/or detecting target molecule compounds of wine.
US20140240074 Systems And Methods For Making Radially Anisotropic Thin-Film Magnetic Torroidal Cores, And Radially Anisotropic Cores Having Radial Anisotropy, And Inductors Having Radially Anisotropic Cores  
A radially anisotropic toroidal magnetic core is fabricated by a method including providing apparatus having a first magnet for providing a radial magnetic field extending across a cavity from an...
8816094 Hydrothiolation of unactivated alkenes  
The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.
US20140228392 COMPOSITIONS AND METHODS FOR TREATING CANCER  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
US20140227795 Molecularly Imprinted Polymers For Detection Of Contaminants  
This disclosure relates to the field of molecularly imprinted polymers for detecting target molecules.
8802646 Method for selectively inhibiting the activity of ACAT1 in the treatment of alzheimer's disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
US20140220706 Molecularly Imprinted Polymer for Detecting Waterborne Target Molecules and Improving Water Quality  
This disclosure relates to the field of molecularly imprinted polymers for detecting or removing target molecules.
US20140220114 METHODS FOR TREATING NIEMANN-PICK TYPE C DISEASE  
The present invention includes methods for treating Niemann-Pick Type C disease through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are...
US20140220012 Novel VISTA-Ig constructs and the use of VISTA-Ig for Treatment of Autoimmune, Allergic and Inflammatory Disorders  
The present invention relates to a fusion proteins comprising regulatory T cell protein, VISTA (V-domain Immunoglobulin Suppressor of T cell Activation (PD-L3) and an immunoglobulin protein (Ig),...
US20140219926 Biodegradable Iron Oxide Nanoparticle Gel for Tumor Bed Therapy  
A biodegradable iron oxide nanoparticle gel for hyperthermia treatment of cancer includes a polysaccharide-based carrier matrix and starch-coated iron oxide nanoparticles. The gel has sufficient...
8799754 Verification of data stream computations using third-party-supplied annotations  
A third party that performs data stream computation is requested to return not only the solution to the computation, but also “annotations” to the original data stream. The annotations are then...
8778990 Betulinic acid derivatives and methods of use thereof  
This invention features betulinic acid derivatives having the formula: wherein the variables are defined herein. The invention also provides related compounds and intermediates thereof, as well as...
8778903 MicroRNA-10 antagonists and MicroRNA-10 targets for use in the treatment of a glioma  
The present invention embraces microRNA-antagonists and activators of homeobox D10 protein; Zinc finger, MYND domain containing 11 protein; or RB1-inducible coiled-coil 1 protein for use in...
8765781 Bis-carbazole DNA intercalating agents for antitumor therapy  
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an antitumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing...
8760135 High-efficiency base-driver circuit for power bipolar junction transistors  
A system or module has a 3-or-more layer current-controlled switching device, such as a bipolar power transistor, for driving a load and a base driver circuit coupled to drive it. The driver has a...
US20140170210 METHODS FOR TREATING IMMUNOSUPPRESSION  
The present invention includes methods for increasing white blood cell counts through administration of inhibitors of acyl-coenzyme A:cholesterol acyltransferase 1 (ACAT1). ACAT inhibitors are...
8753029 System and methods for smoothly inverting one or more faces of a cubical device  
A system and method for inverting a cubical device 100 that inverts one or more faces of the cubical device 100 in a single fluid motion. In an embodiment, the cube faces are split in two face...
US20140158020 Ice-Tempered Hybrid Materials  
A metal-polymer composite scaffold includes metal particles coupled with polymer binder, the scaffold having regions of aligned porosity with a gradient. In a particular embodiment, the metal...