Patents and Patent Applications from Dartmouth College


Match Document Document Title
US20130338479 Apparatus And Method For Surgical Instrument With Integral Automated Tissue Classifier  
A method and apparatus is described for optically scanning a field of view, the field of view including at least part of an organ as exposed during surgery, and for identifying and classifying...
US20130336983 PROGNOSIS AND TREATMENT OF BREAST CANCER  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
8609927 Caveolin 1-reporter protein knock-in mouse  
The present invention embraces a transgenic mouse whose genome harbors a nucleic acid molecule encoding caveolin-1 fused in-frame with a reporter. To control expression of the Cav1-reporter, the...
8609610 Inhibitors of the trypsin-like site of the proteasome and methods of use thereof  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an...
8609087 Compounds and methods for identifying compounds which inhibit a new class of aspartyl proteases  
Compounds and methods for designing and identifying compounds which inhibit TFPP-like aspartyl protease enzymes by targeting the aspartic acid residues of the active site or mimicking peptides...
US20130328165 MICROFABRICATED MAGNETIC DEVICES AND ASSOCIATED METHODS  
A magnetic device includes a semiconductor wafer, a spiral winding, and a magnetic core. The spiral winding forms a plurality of turns and is disposed in a channel of the semiconductor wafer. The...
US20130322215 Acoustic Sensor With An Acoustic Object Detector For Reducing Power Consumption In Front-End Circuit  
An acoustic object detector for detecting presence of an acoustic signal is provided. The acoustic object detector includes a number of bandpass filters. Each bandpass filter is configured to...
8592168 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
US20130310305 METHODS FOR INCREASING PLASMIN ACTIVITY AND PROMOTING PLAQUE REGRESSION IN THE TREATMENT OF ATHEROSCLEROSIS  
The present invention provides the use of recombinant plasminogen activator inhibitor-1 (PAI-1) isoform 23 in methods of increasing plasmin activity, inhibiting angiogenic vasa vasorum, promoting...
8586775 Therapeutic compounds and methods of use  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
8586029 Prevention or treatment of immune-relevant disease by modification of microfloral populations  
The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
US20130303874 System And Method For Optode And Electrode Positioning Cap For Electroencephalography, Diffuse Optical Imaging, and Functional Neuroimaging  
An electroencephalographic electrode and optode positioning device has the form of a cap suitable for placement on a subject's head. The cap has semirigid telescopic structures that stiffen it to...
US20130303797 METHOD FOR SYNTHESIZING 2-CYANO-3,12-DIOXOOLEAN-1, 9(11)-DIEN-28-OIC ACID METHYL ESTER AND DERIVATIVES THEREOF  
The present invention is a method for preparing triterpenoids such as 2-cyano-3,12-dioxoolean-1,9-dien-28-methyl ester and derivatives thereof from oleanic acid, ursolic acid, betulinic acid,...
US20130303607 Triterpenoids and Compositions Containing the Same  
The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
US20130302870 Flowthrough Pretreatment Of Lignocellulosic Biomass And Selective Separation Of Components Using High-Temperature Nanoporous Membranes  
A new and improved biomass conversion system is disclosed using high-temperature flow-though pretreatment and a nanoporous membrane to provide more digestible biomass for subsequent conversion to...
US20130302408 Carrier-Linked Magnetic Nanoparticle Drug Delivery Composition and Method of Use  
The present invention is a targeted drug delivery composition composed of carrier-linked magnetic nanoparticles. Using an alternating magnetic field, nanoparticles bound to a targeted cell are...
8580541 Lignin blockers and uses thereof  
Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment...
8580513 Methods for determining response to neoadjuvant therapy and survival using MicroRNA-10b  
The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression...
8580278 Nutraceutical composition and methods for preventing or treating multiple sclerosis  
The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
US20130296399 microRNA Biomarkers for Human Breast and Lung Cancer  
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
US20130295578 METHODS FOR SCREENING FOR DRUG RESISTANCE IN CANCER TREATMENT  
The present invention includes methods for screening for drug resistance in cancer tissue ex vivo which comprises a novel 3-dimensional cell culture system that mimics the tumor microenvironment.
US20130295017 METHODS FOR SCREENING ANTIBIOTIC COMPOUNDS  
The present invention is a method for screening drugs or antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
US20130288385 MOLECULARLY IMPRINTED TETRAETHOXYSILANE POLYMER AND METHODS OF USING THE SAME TO DETECT SECOSTEROIDS  
A molecular imprinted tetraethoxysilane polymer device for detecting secosteroids, or metabolites thereof, and a method for using the same are provided.
US20130288362 COMPOSITIONS AND METHODS FOR PRODUCING ADAPTIVE REGULATORY T CELLS  
The present invention relates to a method for producing adaptive regulatory T cells from effector T cells by contacting the effector T cells with retinoic acid. Adaptive regulatory T cells...
US20130274480 MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
8554087 System and method for imaging objects through turbid media  
A method for imaging objects through turbid media includes generating a repetitive pulsed light beam under control of a pulse shaper, propagating the light beam through turbid media, and receiving...
US20130237721 THERAPEUTIC COMPOUNDS AND METHODS OF USE  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
8530496 Compositions and methods for treating cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
8527035 System, optode and cap for near-infrared diffuse-optical function neuroimaging  
An optode for a functional infrared diffuse optical neuroimaging system uses a GRIN lens and prism for coupling to an optical fiber at a right-angle to the lens. The lens is inserted into a...
US20130221753 POWER PROCESSING METHODS AND APPARATUS FOR PHOTOVOLTAIC SYSTEMS  
High power output may be obtained from a photovoltaic (PV) system by controlling each photovoltaic cell of a solar array individually to operate at its maximum power point. Each cell may have...
8518965 Compositions and methods for treating cancer  
The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and...
US20130206374 GEOMETRY OF HEAT EXCHANGER WITH HIGH EFFICIENCY  
The present disclosure includes geometry of a two-fluid heat exchanger to provide higher energy efficiency than conventional heat exchangers. The geometry is based upon sequential branching of...
US20130204118 SYSTEM AND METHOD FOR COLLECTION & USE OF MAGNETIC RESONANCE DATA & MICROWAVE DATA TO IDENTIFY BOUNDARIES OF INTEREST  
A system and method for detecting permittivity and conductivity boundaries within a high resolution spatial image of a material is presented. Electrical properties of a material, such as...
8501915 Regulatory T cell mediator proteins and uses thereof  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A...
8496603 Wire torque apparatus, wire insertion devices, improved aneurysm clips and improved aneurysm clip applicators  
Wire torque apparatus and methods for engaging a wire torque apparatus are disclosed. Wire insertion devices and methods for inserting a wire into a catheter are disclosed. An improved aneurysm...
US20130190505 Hydrothiolation of Unactivated Alkenes  
The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.
US20130190395 AUTOIMMUNE DISORDER TREATMENT USING RXR AGONISTS  
The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation...
US20130186455 METHOD OF FORMING SINGLE-CRYSTAL SEMICONDUCTOR LAYERS AND PHOTOVALTAIC CELL THEREON  
A method for forming single crystal or large-crystal-grain thin-film layers deposits a thin-film amorphous, nanocrystalline, microcrystalline, or polycrystalline layer, and laser-heats a seed spot...
8485978 Systems and methods for noninvasively monitoring baroreflex response and nominal blood volume  
Systems and methods for noninvasively monitoring baroreflex response and nominal blood volume are disclosed herein. Software and methods for evaluating morphological features of a...
US20130177557 VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING AGENTS AND USE THEREOF  
The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct,...
US20130176010 High-Efficiency Base-Driver Circuit For Power Bipolar Junction Transistors  
A system or module has a 3-or-more layer current-controlled switching device, such as a bipolar power transistor, for driving a load and a base driver circuit coupled to drive it. The driver has a...
US20130170670 System And Method For Automatically Remixing Digital Music  
Systems and methods augment a target media with a plurality of source media. The target media and source media are processed to form time frequency distributions (TFDs). Target features are...
8473060 Apparatus and method for modulating neurochemical levels in the brain  
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
8466121 Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
8465740 Regulatory T cell mediator proteins and uses thereof  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A...
US20130145199 METHODS AND SYSTEMS FOR IMPROVING SECURITY IN ZERO-POWER DEVICES  
Methods and systems for providing lime information in intermittently powered devices that are batteryless and operate purely on harvested energy (also referred to as zero power devices). The...
8455544 Synthetic triterpenoids and methods of use in the treatment of disease  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
8455431 Inhibitors of the trypsin-like site of the proteasome and methods of use thereof  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an...
US20130136734 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND RELATED THERAPIES  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
US20130135450 3d Scanning Laser Systems And Methods For Determining Surface Geometry Of An Immersed Object In A Transparent Cylindrical Glass Tank  
Systems and methods generate a 3D model of a surface of an object immersed in a transparent liquid within a stationary cylindrical transparent tank. First and second laser line projectors and a...