Sign up

Patents and Patent Applications from Dartmouth College


Match Document Document Title
8097249 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate D4+ and CD8+ T cell immunity
 
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
US20120003114 Nanostructured Mn-Al Permanent Magnets And Methods of Producing Same  
A bulky consolidated nanostructured manganese aluminum alloy includes at least about 80% of a magnetic τ phase and having a macroscopic composition of MnXAlYDoZ, where Do is a dopant, X ranges ...
8084217 CD161 ligand, pilar, for modulating activation and proliferation of T cells  
The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly...
8068898 Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissues  
This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data acquisition...
8067583 Method for synthesizing furanosteroids  
The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole...
8067465 Tricyclic-bis-enone derivatives and methods of use thereof  
Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's...
8067394 Synthesis and biological activities of new tricyclic-bis-enones (TBEs)  
This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The...
US20110287499 Nucleic Acid Molecules Conferring Enhanced Ethanol Tolerance And Microorganisms Having Enhanced Tolerance To Ethanol  
The present invention provides isolated nucleic acid molecules which encode a mutant acetaldehyde-CoA/alcohol dehydrogenase or mutant alcohol dehydrogenase and confer enhanced tolerance to ethanol....
US20110278417 System And Methods For Smoothly Inverting One Or More Faces Of A Cubical Device  
A system and method for inverting a cubical device 100 that inverts one or more faces of the cubical device 100 in a single fluid motion. In an embodiment, the cube faces are split in two face...
US20110259880 MECHANICAL SCRAPER SYSTEM WITH SYNCHRONIZED PULSE ELECTROTHERMAL DEICING  
A mechanical scraper with synchronized pulse electrothermal deicing includes a heating element that is coupled to a power supply and that is operable to convert power from the power supply into...
US20110256601 MODIFICATION OF HYDROGENASE ACTIVITIES IN THERMOPHILIC BACTERIA TO ENHANCE ETHANOL PRODUCTION  
Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced...
8034955 Therapeutic compounds and methods of use  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
US20110244539 Selection Of Cellulolytic Microbes With High Growth Rates  
Methods for obtaining cellulolytic microbes with high growth rates are disclosed. For example, C. thermocellum colonies with growth rates higher than 0.17 hr″ 1 have been obtained by the present m...
8030446 Mutant proline-and-arginine rich peptides and methods for using the same  
The present invention relates to mutant proline-and-arginine rich (PR) peptides with defined structural characteristics for use in inhibiting mammalian 20S proteasome activity and modulating...
US20110237656 Method of Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
US20110201544 Compositions and Methods for Inhibiting the Interaction between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8000775 Systems and methods for tomographic image reconstruction  
Optical tomography systems that provide light of multiple distinct wavelengths from a plurality of sources are described. The systems direct light into mammalian tissue, and light from the...
US20110196007 MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
7994298 Chimeric NK receptor and methods for treating cancer  
The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a...
7993659 TLR9 agonist and CD40 agonist immunostimulatory combinations  
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
US20110190156 MOLECULAR SIGNATURES FOR DIAGNOSING SCLERODERMA  
The present invention features methods for classifying, determining severity, and predicting clinical endpoints of scleroderma based upon the expression of selected biomarker genes.
US20110187100 System and Method for Providing Knot Tying  
A knot tying system is presented containing a feeding mechanism, a knot tying device, and a clamp. The feeding mechanism has a drive roller and an idle roller capable of guiding a wire. A truck is...
7981058 Intelligent wearable monitor systems and methods  
An intelligent wearable monitoring system includes a wireless personal area network for extended monitoring of a patient's motor functions. The wireless personal area network includes an...
US20110159010 Compositions and Methods for Decreasing Type III Deiodinase Activity to Modulate Adiposity and Blood Glucose Levels  
The present invention features methods for decreasing fat mass, increasing energy expenditure, increasing resistance to obesity, and lowering blood glucose levels in a subject with an agent that...
US20110158911 Methods for Screening for Antibiotic Compounds  
The present invention is a method for screening drugs for antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
US20110153254 System And Method For Calibration For Image-Guided Surgery  
A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method comprising applying a transformation...
US20110152358 Compositions and Methods for Diagnosis and Treatment of Pancreatic Ductal Cancer  
The present invention includes compositions and methods for diagnosing and treating pancreatic cancer. These compositions and methods are based on the finding that 14-3-3σ protein is secreted from ...
US20110150876 Prognosis and Treatment of Breast Cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
US20110149281 ROTARYFROG SYSTEMS AND METHODS  
Systems and methods determining amplitude and phase versus frequency of an incoming beam of pulsed laser light. An apparatus is set to an initial configuration to split the incoming beam into two...
US20110139964 Systems And Methods That Detect Changes In Incident Optical Radiation  
Systems, methods and sensors detect changes in incident optical radiation. Voltage is applied across one or more active areas of a detector while the incident optical radiation illuminates the...
7962198 System and method for spectral-encoded high-rate hemodynamic tomography  
An optical tomography system has a group of lasers for generating light of multiple distinct wavelengths within a first wavelength band. Light from these lasers is directed into mammalian tissue at...
US20110138264 Verification Of Data Stream Computations Using Third-Party-Supplied Annotations  
A third party that performs data stream computation is requested to return not only the solution to the computation, but also “annotations” to the original data stream. The annotations are then use...
7955848 MicroRNA biomarkers for human breast and lung cancer  
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
US20110130647 System And Method Using Coupler-Resonators For Electron Paramagnetic Resonance Spectroscopy  
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor...
US20110118336 Microrna-21 antagonists and its target PDCD4 for use in the treatment of a glioma  
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
US20110118296 Bis-Carbazole DNA Intercalating Agents for Antitumor Therapy  
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, con...
7943588 Method for preventing or treating neuropathic pain  
The present invention is a method for preventing or treating neuropathic pain. Using an agent to decrease the expression or activity of Toll-like receptor 4 (TLR4), behavioral hypersensitivity is...
7939499 Method for increasing cardiac mass and performance  
The present invention relates to methods of using a proline/arginine-rich peptide such as PR11 or PR39 for increasing cardiac mass or performance and in the treatment of heart failure.
US20110105948 Electrical Impedance Sensing Biopsy Sampling Device And Method  
A biopsy sampling device has an inner trocar having a sharpened tip and a sampling opening. The trocar is slideably engaged in a central cavity of an outer needle with its sharpened tip and...
US20110104121 Female Reproductive Tract and Anal Prophylaxes  
The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post-menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor...
US20110104073 Iron/Iron Oxide Nanoparticle and Use Thereof  
The present invention is a nanoparticle composition composed of an iron core with an iron oxide shell which is optionally coated with a micro-emulsion. The disclosed nanoparticle compositions are...
US20110098558 SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND DIAGNOSIS  
A method for diagnosing certain types of cancers provides a nanoparticle agent to be uptaken by cancer cells for diagnosis and treatment of certain cancers. A compound containing nanoparticles is...
US20110091484 Compositions and methods for preventing or treating a viral infection  
The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in...
US20110086022 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
US20110086011 Prevention or Treatment of Immune-Relevant Disease by Modification of Microfloral Populations  
The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
US20110079631 Joining Of Parts Via Magnetic Heating Of Metal-Aluminum Powders  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least...
7919500 Bis-carbazole DNA intercalating agents for antitumor therapy  
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, con...
US20110076725 Lignin Blockers And Uses Thereof  
Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment...
7906514 Animal model and compounds identified via this model for treatment of chronic pain  
An animal model for chronic pain, and in particular lower back pain, is provided. Methods of identifying agents and reducing chronic pain with identified agents such as methotrexate are also provided.
7906294 Prognosis and treatment of breast cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...