Patents and Patent Applications from Dartmouth College


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US20130136734 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND RELATED THERAPIES  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
US20130135450 3d Scanning Laser Systems And Methods For Determining Surface Geometry Of An Immersed Object In A Transparent Cylindrical Glass Tank  
Systems and methods generate a 3D model of a surface of an object immersed in a transparent liquid within a stationary cylindrical transparent tank. First and second laser line projectors and a...
US20130129234 Perceptual Rating Of Digital Image Retouching  
A method is provided for automatically providing a digital image rating of photo retouching. The method includes the step of receiving at a computer, including a processor, a first set of pixel...
8444045 Joining of parts via magnetic heating of metal aluminum powders  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase magnetic metal-aluminum powder at an interface between the at least two parts to be...
US20130123613 Magnetic Particle Heating System And Method For Occlusion Of The Fallopian Tube  
In a magnetic particle heating method for occlusion of the Fallopian tubes, biocompatible magnetic particles are delivered transcervically to the entrance of the Fallopian tube. Placement of the...
US20130122053 SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH  
The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids...
US20130115228 IMMUNOSTIMULATORY COMBINATIONS  
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
US20130108621 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND THE USE THEREOF IN IMMUNE THERAPIES  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity,...
8433415 Apparatus and method for modulating neurochemical levels in the brain  
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
US20130102527 INHIBITORS OF THE TRYPSIN-LIKE SITE OF THE PROTEASOME AND METHODS OF USE THEREOF  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an...
8424324 Refrigerant evaporators with pulse-electrothermal defrosting  
An pulse electro thermal defrost evaporator system has multiple refrigerant tubes formed from an electrically conductive metal and connected in parallel for refrigerant flow. These tubes are,...
US20130092678 System And Method For De-Icing Conductive Objects Utilizing At Least One Variable Resistance Conductor With High Frequency Excitation  
A conductor of a power transmission line has its effective resistance to flow of direct current or low-frequency current (such as, for example, 50 Hz or 60 Hz) varied in a wide range to pass...
8418484 Compact helical heat exchanger with stretch to maintain airflow  
A heat exchanger for exchanging heat between gasses such as air and a liquid or gaseous coolant has narrow spacing between exchanger surfaces for high efficiency. To avoid undue obstruction of gas...
US20130089526 Methods for Using Synthetic Triterpenoids in the Treatment of Bone or Cartilage Diseases or Conditions  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
8417324 Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissue  
This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data...
8416076 Magnetic proximity sensor system and associated methods of sensing a magnetic field  
A magnetic proximity sensor is attached to a ferrous object such that the sensor alerts a practitioner if a threshold of magnetic strength has been exceeded by bringing the ferrous object within a...
8415292 Compositions and methods for inhibiting the interaction between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8415154 Compositions and methods for producing adaptive regulatory T cells  
The present invention relates to a method for producing adaptive regulatory T cells from effector T cells by contacting the effector T cells with retinoic acid. Adaptive regulatory T cells...
8415109 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
8414035 System and method for providing knot tying  
A knot tying system is presented containing a feeding mechanism, a knot tying device, and a clamp. The feeding mechanism has a drive roller and an idle roller capable of guiding a wire. A truck is...
US20130085263 METHOD FOR NON-COVALENT IMMOBILIZATION OF INFECTIOUS PRION PROTEIN  
The present invention is method for non-covalently immobilizing an infectious prion protein using a magnetic substrate.
8405002 Pulse electrothermal mold release icemaker with safety baffles for refrigerator  
An icemaker and a refrigerator having an icemaker are discussed. The icemaker has pulse-electrothermal ice release and includes an ice-making tray having several ice forming portions in which...
US20130065274 Recombinant Prokaryotes and Use Thereof for Production of O-Glycosylated Proteins  
The present invention embraces a recombinant prokaryotic host cell containing nucleic acids encoding an eukaryotic UDP-GaINAc:UDP-GaINAc polypeptide transferase and expressing an UDP-GIcNAc C-4...
8394611 Process for the treatment of lignocellulosic biomass  
A process for the treatment of biomass to render structural carbohydrates more accessible and/or digestible using concentrated ammonium hydroxide with or without anhydrous ammonia addition, is...
US20130060005 COMPOSITIONS AND METHODS FOR INHIBITING THE INTERACTION BETWEEN CFTR AND CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8383086 Nicotinamide riboside kinase compositions and methods for using the same  
The present invention relates to isolated nicotinamide riboside kinase (Nrk) nucleic acid sequences, vectors and cultured cells containing the same, and Nrk polypeptides encoded thereby. Methods...
US20130044185 Operative Microscope Having Diffuse Optical Imaging System With Tomographic Image Reconstruction And Superposition In Field Of View  
An imaging system has a microscope having an objective lens and a projection device configured to project spatially modulated light in one of several preselected predetermined pattern through the...
8379215 Rotaryfrog systems and methods  
Systems and methods determining amplitude and phase versus frequency of an incoming beam of pulsed laser light. The incoming beam is split into two beams of substantially equal intensity, one of...
US20130041016 Compositions and Methods for Preventing and Treating Cancer via Modulating UBE1L, ISG215 and/or UBP43  
Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer...
US20130040399 Airborne Contaminant Sensor Device and Method for Using the Same  
The present invention is a nanotechnology-based personal sensor device composed of molecularly imprinted polymers that are interrogated using radio frequency identification (RFID) technology for...
US20130040327 Methods for Identifying Allosteric and Other Novel Acyl-Coenzyme A:Cholesterol Acyltransferase Inhibitors  
The present invention is a method for identifying compounds that are allosteric and/or other novel ACAT inhibitors that is based on the novel finding that pregnenolone is a substrate for ACAT;...
US20130035357 Compositions and Methods for Preventing Joint Destruction in Osteoarthritis  
The present invention is methods for inhibiting collagen destruction in joints of osteoarthritis patients. The methods are based on use of rexinoid compounds, in particular bexarotene, and their...
8368421 Micromagnetic elements, logic devices and related methods  
Micromagnetic elements, logic devices and methods of fabricating and using them to store data and perform logic operations are disclosed. Micromagnetic elements for data storage, as well as those...
US20130023439 Method and Kit for Determining Sensitivity to Decitabine Treatment  
The present invention is a gene expression panel of chemotherapeutic drug-resistant cancer stem cells comprising RIN1, SOX15 and TLR4. In one embodiment the cancer stem cells are testicular cancer...
8357667 Compositions and methods for treating pancreatic cancer  
The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA...
US20130017252 Method for Selectively Inhibiting the Activity of ACAT1 in the Treatment of Alzheimer's Disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
8348936 Thermal treatment systems with acoustic monitoring, and associated methods  
A thermal treatment system with acoustic monitoring applies substantially constant electromagnetic energy superposed with pulsed electromagnetic energy to targeted tissue. The pulsed...
US20130005747 METHOD FOR SELECTING A CANCER THERAPY  
The present invention provides a method for determining whether or not a cancer subject is suitable for treatment with a purine-based roscovitine-like inhibitor, which method comprises the step of...
US20120327075 SYSTEM FOR RAPID AND ACCURATE QUANTITATIVE ASSESSMENT OF TRAUMATIC BRAIN INJURY  
A system and method for automatic segmentation, performed by selecting a deformable model of an anatomical structure of interest imaged in a volumetric image, the deformable model formed of a...
8341424 Methods for playing protected content  
One aspect of the present invention is a method of playing multi-media content through a personal computer. The personal computer includes a processor and memory, with the memory having software...
US20120321667 T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20120315493 JOINING OF PARTS VIA MAGNETIC HEATING OF METAL ALUMINUM POWDERS  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase magnetic metal-aluminum powder at an interface between the at least two parts to be...
8329197 Ex vivo uses of immunostimulatory combinations  
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
US20120302581 Methods and Compositions for the Treatment of RAS Associated Disorders  
The instant disclosure relates to compositions that may be useful as therapeutic agents for the treatment of disorders associated or caused by Ras deregulation or dysregulation, for example,...
US20120302466 T CELL RECEPTOR-DEFICIENT T CELL COMPOSITIONS  
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In...
US20120301457 LIPID COFACTORS FOR FACILITATING PROPOGATION OF PRPsc  
The present invention embraces methods and kits for facilitating the propogation of PrPSc, and use of the same in increasing the sensitivity diagnostic assays and in identifying compounds that...
US20120295306 Modified CIPA Gene From Clostridium Thermocellum for Enhanced Genetic Stability  
Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic...
US20120294857 Monomeric Bi-Specific Fusion Protein  
The present invention embraces a bi-specific fusion protein composed of an effector cell-specific antibody-variable region fragment operably linked to at least a portion of a natural killer cell...
8314137 Monocyclic cyanoenones and methods of use thereof  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
US20120281947 System And Method For Coupling A Multi-Mode Optical Fiber To A Single Mode Optical Fiber  
A multi-mode to single mode optical interface device includes an optically pumped edge emitting semiconductor laser device and a lens. The optically pumped edge emitting semiconductor laser device...