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Patents and Patent Applications from Dartmouth College


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US20110153254 System And Method For Calibration For Image-Guided Surgery  
A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method comprising applying a transformation...
US20110152358 Compositions and Methods for Diagnosis and Treatment of Pancreatic Ductal Cancer  
The present invention includes compositions and methods for diagnosing and treating pancreatic cancer. These compositions and methods are based on the finding that 14-3-3σ protein is secreted from ...
US20110150876 Prognosis and Treatment of Breast Cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
US20110149281 ROTARYFROG SYSTEMS AND METHODS  
Systems and methods determining amplitude and phase versus frequency of an incoming beam of pulsed laser light. An apparatus is set to an initial configuration to split the incoming beam into two...
US20110139964 Systems And Methods That Detect Changes In Incident Optical Radiation  
Systems, methods and sensors detect changes in incident optical radiation. Voltage is applied across one or more active areas of a detector while the incident optical radiation illuminates the...
7962198 System and method for spectral-encoded high-rate hemodynamic tomography  
An optical tomography system has a group of lasers for generating light of multiple distinct wavelengths within a first wavelength band. Light from these lasers is directed into mammalian tissue at...
US20110138264 Verification Of Data Stream Computations Using Third-Party-Supplied Annotations  
A third party that performs data stream computation is requested to return not only the solution to the computation, but also “annotations” to the original data stream. The annotations are then use...
US20110132588 System and Method for Energy-Saving Inductive Heating of Evaporators and Other Heat-Exchangers  
The present invention provides a novel fins-on-tubes type evaporator/heat exchanger system that is optimized for energy-saving inductive heating thereof, for example by way of application of Pulse...
7955848 MicroRNA biomarkers for human breast and lung cancer  
The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
US20110130647 System And Method Using Coupler-Resonators For Electron Paramagnetic Resonance Spectroscopy  
A coupler-resonator for electron paramagnetic resonance (EPR) spectroscopy in subjects has a wire loop formed into a coupling loop, a central transmission portion, and sensor loops. The sensor...
US20110118336 Microrna-21 antagonists and its target PDCD4 for use in the treatment of a glioma  
The present invention embraces microRNA-21 antagonists and activators of Programmed Cell Death 4 for use in decreasing glial tumor cell proliferation and treating glioma.
US20110118296 Bis-Carbazole DNA Intercalating Agents for Antitumor Therapy  
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, con...
7943588 Method for preventing or treating neuropathic pain  
The present invention is a method for preventing or treating neuropathic pain. Using an agent to decrease the expression or activity of Toll-like receptor 4 (TLR4), behavioral hypersensitivity is...
7939499 Method for increasing cardiac mass and performance  
The present invention relates to methods of using a proline/arginine-rich peptide such as PR11 or PR39 for increasing cardiac mass or performance and in the treatment of heart failure.
US20110105948 Electrical Impedance Sensing Biopsy Sampling Device And Method  
A biopsy sampling device has an inner trocar having a sharpened tip and a sampling opening. The trocar is slideably engaged in a central cavity of an outer needle with its sharpened tip and...
US20110104121 Female Reproductive Tract and Anal Prophylaxes  
The present invention provides methods for boosting mucosal immunity in the female reproductive tract of pre- and post-menopausal women using a TGF-beta inhibitor, a Selective Estrogen Receptor...
US20110104073 Iron/Iron Oxide Nanoparticle and Use Thereof  
The present invention is a nanoparticle composition composed of an iron core with an iron oxide shell which is optionally coated with a micro-emulsion. The disclosed nanoparticle compositions are...
US20110098558 SYSTEM AND METHOD FOR USE OF NANOPARTICLES IN IMAGING AND DIAGNOSIS  
A method for diagnosing certain types of cancers provides a nanoparticle agent to be uptaken by cancer cells for diagnosis and treatment of certain cancers. A compound containing nanoparticles is...
US20110091484 Compositions and methods for preventing or treating a viral infection  
The present invention is a composition for enhancing the immunogenicity of viral vaccine. The composition encompasses a viral vaccine in combination with at least one toll-like receptor and, in...
US20110086022 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
US20110086011 Prevention or Treatment of Immune-Relevant Disease by Modification of Microfloral Populations  
The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
US20110079631 Joining Of Parts Via Magnetic Heating Of Metal-Aluminum Powders  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase nanocrystalline magnetic metal-aluminum powder at an interface between the at least...
7919500 Bis-carbazole DNA intercalating agents for antitumor therapy  
The present invention is a DNA intercalating agent represented by the structure Y—Z—Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, con...
US20110076725 Lignin Blockers And Uses Thereof  
Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment...
7906514 Animal model and compounds identified via this model for treatment of chronic pain  
An animal model for chronic pain, and in particular lower back pain, is provided. Methods of identifying agents and reducing chronic pain with identified agents such as methotrexate are also provided.
7906294 Prognosis and treatment of breast cancer  
The present invention relates to an antibody which specifically binds a Spot 14 (S14 or THRSP) protein in human breast cancer cells and a method for using the same to predict disease-free survival...
US20110046491 System, Optode And Cap For Near-Infrared Diffuse-Optical Function Neuroimaging  
An optode for a functional infrared diffuse optical neuroimaging system uses a GRIN lens and prism for coupling to an optical fiber at a right-angle to the lens. The lens is inserted into a grommet...
US20110041967 Eutectic Alloys of the Type FE 25-35 NI 15-25 MN 30-40 AL 10-20 M 0-5 and Methods for Production Thereof  
Alloys, formed by a eutectic transformation of the type Fe25-35 Ni15-25 Mn30-40 Al10-20 MO-5, are disclosed. M is selected from chromium, molybdenum, carbon and combinations thereof. The alloys...
US20110039765 Bioactive Molecules Produced by Probiotic Bacteria  
The present invention is a method for isolating bioactive molecules secreted by probiotic bacteria such as Lactobacillus rhamnosus, and methods for using such bioactive molecules to decrease...
US20110034806 Systems And Methods For Combined Ultrasound And Electrical Impedance Imaging  
A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical...
7883609 Ice modification removal and prevention  
An alternating electric field is applied to ice (530) to generate a resistive AC having a frequency greater than 1000 Hz in interfacial ice at interface (554). A first electrode (510) and a second...
US20110027278 REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A ...
7875444 Lignin blockers and uses thereof  
Disclosed is a method for converting cellulose in a lignocellulosic biomass. The method provides for a lignin-blocking polypeptide and/or protein treatment of high lignin solids. The treatment...
US20110014202 Methods for Diagnosing and Treating Neuroendocrine Cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
7871776 Compositions and methods for enhancing the identification of prior protein PrPSc  
A method for purifying PrPc, a purified preparation of PrPc and methods and kits for identifying the presence of PrPc are provided.
US20110009360 Nutraceutical Composition and Methods for Preventing or Treating Multiple Sclerosis  
The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
7863327 Therapeutic compounds and methods of use  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
US20100322905 Compositions and methods for treating pancreatic cancer  
The present invention provides a method of treating pancreatic cancer by inhibiting the activity cyclin D1 activity in tumor cells. The invention is based on the finding that cyclin D1 shRNA...
US20100312305 Apparatus And Method For Modulating Neurochemical Levels In the Brain  
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
US20100311686 Nutraceutical composition and methods for preventing or treating multiple sclerosis  
The present invention embraces nutraceutical compositions containing isolated Bacteroides fragilis capsular polysaccharide A for use in methods of preventing or treating multiple sclerosis.
US20100305658 APPARATUS AND METHOD FOR MODULATING NEUROCHEMICAL LEVELS IN THE BRAIN  
The present invention provides a method for modulating or regulating levels of a neurochemical in an individual using deep brain stimulation. More particularly, the invention relates to a method of...
7842468 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2. Methods...
US20100299615 System And Method For Injecting Sensed Presence Into Social Networking Applications  
A method for injecting sensed presence into social networking applications includes receiving sensor data associated with a user (102), inferring a presence status of the user based upon analysis...
US20100297017 Method for Synthesizing and Using Pegylated Peptide-Photoactive Chromophore Conjugates and Micellular Formulations Thereof  
The invention relates to a PEGylated peptide-chromophore conjugate, which forms irregular micelles, for use in photodiagnostic and phototherapeutic applications. Methods for synthesizing and using...
7829843 Electronic time-of-flight mass selector  
A method of selecting ions includes generating a group of ions, accelerating the group of ions through a flight region towards an electronic mass selector grid, and selectively varying a voltage...
US20100265493 Pulsed Lasers in Frequency Domain Diffuse Optical Tomography and Spectroscopy  
A diffuse optical tomography system incorporating a mode-locked, tunable laser produces pulsed light that may be used to interrogate tissue with high spatial and spectral resolution. The detection...
7815850 High-strength nanostructured alloys  
Biphasic alloys, formed through a spinodal decomposition process, are disclosed. The alloys have improved strength and hardness, over single phase alloys, due to coherency strain between the...
US20100260804 Attenuated Uracil Auxotroph of an Apicomplexan and Use Thereof  
Uracil auxotroph mutants of apicomplexans are provided which lack a functional carbamoyl phosphate synthase II (CPSII) enzyme. Also provided are T. gondii autoxtroph mutants which express exogenous...
US20100256063 Method for Increasing Cardiac Mass and Performance  
The present invention relates to methods of using a proline/arginine-rich peptide such PR11 or PR39 for increasing cardiac mass or performance and in the treatment of heart failure.
7803389 Toxoplasma gondii mutant with enhanced homologous recombination and uses thereof  
The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous...