Patents and Patent Applications from Dartmouth College


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US20130295578 METHODS FOR SCREENING FOR DRUG RESISTANCE IN CANCER TREATMENT  
The present invention includes methods for screening for drug resistance in cancer tissue ex vivo which comprises a novel 3-dimensional cell culture system that mimics the tumor microenvironment.
US20130295017 METHODS FOR SCREENING ANTIBIOTIC COMPOUNDS  
The present invention is a method for screening drugs or antibiotic activity by screening a drug for activity to disrupt a toxin-antitoxin complex in a bacterial cell.
US20130288385 MOLECULARLY IMPRINTED TETRAETHOXYSILANE POLYMER AND METHODS OF USING THE SAME TO DETECT SECOSTEROIDS  
A molecular imprinted tetraethoxysilane polymer device for detecting secosteroids, or metabolites thereof, and a method for using the same are provided.
US20130288362 COMPOSITIONS AND METHODS FOR PRODUCING ADAPTIVE REGULATORY T CELLS  
The present invention relates to a method for producing adaptive regulatory T cells from effector T cells by contacting the effector T cells with retinoic acid. Adaptive regulatory T cells...
US20130274480 MONOCYCLIC CYANOENONES AND METHODS OF USE THEREOF  
The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
8554087 System and method for imaging objects through turbid media  
A method for imaging objects through turbid media includes generating a repetitive pulsed light beam under control of a pulse shaper, propagating the light beam through turbid media, and receiving...
US20130237721 THERAPEUTIC COMPOUNDS AND METHODS OF USE  
Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis.
8530496 Compositions and methods for treating cancer  
The present invention is bis-acridine or bis-quinoline intercalators having a modified bis(4-aminophenyl)ether tether to improve activity, selectivity, solubility and bioavailability of the...
8527035 System, optode and cap for near-infrared diffuse-optical function neuroimaging  
An optode for a functional infrared diffuse optical neuroimaging system uses a GRIN lens and prism for coupling to an optical fiber at a right-angle to the lens. The lens is inserted into a...
US20130221753 POWER PROCESSING METHODS AND APPARATUS FOR PHOTOVOLTAIC SYSTEMS  
High power output may be obtained from a photovoltaic (PV) system by controlling each photovoltaic cell of a solar array individually to operate at its maximum power point. Each cell may have...
8518965 Compositions and methods for treating cancer  
The present invention embraces bis-acridine and bis-quinoline intercalators having a bis(4-aminophenyl)ether tether, and diglycolate salts thereof, for selectively decreasing colon cancer and...
US20130206374 GEOMETRY OF HEAT EXCHANGER WITH HIGH EFFICIENCY  
The present disclosure includes geometry of a two-fluid heat exchanger to provide higher energy efficiency than conventional heat exchangers. The geometry is based upon sequential branching of...
US20130204118 SYSTEM AND METHOD FOR COLLECTION & USE OF MAGNETIC RESONANCE DATA & MICROWAVE DATA TO IDENTIFY BOUNDARIES OF INTEREST  
A system and method for detecting permittivity and conductivity boundaries within a high resolution spatial image of a material is presented. Electrical properties of a material, such as...
8501915 Regulatory T cell mediator proteins and uses thereof  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A...
8496603 Wire torque apparatus, wire insertion devices, improved aneurysm clips and improved aneurysm clip applicators  
Wire torque apparatus and methods for engaging a wire torque apparatus are disclosed. Wire insertion devices and methods for inserting a wire into a catheter are disclosed. An improved aneurysm...
US20130190505 Hydrothiolation of Unactivated Alkenes  
The present invention is a method for promoting hydrothiolation of an unactivated alkenes with a thiol using gallium triflate.
US20130190395 AUTOIMMUNE DISORDER TREATMENT USING RXR AGONISTS  
The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation...
US20130186455 METHOD OF FORMING SINGLE-CRYSTAL SEMICONDUCTOR LAYERS AND PHOTOVALTAIC CELL THEREON  
A method for forming single crystal or large-crystal-grain thin-film layers deposits a thin-film amorphous, nanocrystalline, microcrystalline, or polycrystalline layer, and laser-heats a seed spot...
8485978 Systems and methods for noninvasively monitoring baroreflex response and nominal blood volume  
Systems and methods for noninvasively monitoring baroreflex response and nominal blood volume are disclosed herein. Software and methods for evaluating morphological features of a...
US20130177557 VISTA REGULATORY T CELL MEDIATOR PROTEIN, VISTA BINDING AGENTS AND USE THEREOF  
The present invention relates to a novel regulatory T cell protein. This protein, designated PD-L3 OR VISTA resembles members of the PD-L1 family, identified a novel and structurally-distinct,...
US20130176010 High-Efficiency Base-Driver Circuit For Power Bipolar Junction Transistors  
A system or module has a 3-or-more layer current-controlled switching device, such as a bipolar power transistor, for driving a load and a base driver circuit coupled to drive it. The driver has a...
US20130170670 System And Method For Automatically Remixing Digital Music  
Systems and methods augment a target media with a plurality of source media. The target media and source media are processed to form time frequency distributions (TFDs). Target features are...
8473060 Apparatus and method for modulating neurochemical levels in the brain  
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
8466121 Method of selectively inhibiting the activity of ACAT1 in the treatment of Alzheimer's disease  
The present invention features methods for decreasing the size and density of amyloid plaques, decreasing cognitive decline associated with amyloid pathology, and treating Alzheimer's disease by...
8465740 Regulatory T cell mediator proteins and uses thereof  
The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A...
US20130145199 METHODS AND SYSTEMS FOR IMPROVING SECURITY IN ZERO-POWER DEVICES  
Methods and systems for providing lime information in intermittently powered devices that are batteryless and operate purely on harvested energy (also referred to as zero power devices). The...
8455544 Synthetic triterpenoids and methods of use in the treatment of disease  
The present invention concerns methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease...
8455431 Inhibitors of the trypsin-like site of the proteasome and methods of use thereof  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an...
US20130136734 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND RELATED THERAPIES  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding and/or complement binding/activation. The use of these antibodies for inducing tolerance and treating immune...
US20130135450 3d Scanning Laser Systems And Methods For Determining Surface Geometry Of An Immersed Object In A Transparent Cylindrical Glass Tank  
Systems and methods generate a 3D model of a surface of an object immersed in a transparent liquid within a stationary cylindrical transparent tank. First and second laser line projectors and a...
US20130129234 Perceptual Rating Of Digital Image Retouching  
A method is provided for automatically providing a digital image rating of photo retouching. The method includes the step of receiving at a computer, including a processor, a first set of pixel...
8444045 Joining of parts via magnetic heating of metal aluminum powders  
A method of joining at least two parts includes steps of dispersing a joining material comprising a multi-phase magnetic metal-aluminum powder at an interface between the at least two parts to be...
US20130123613 Magnetic Particle Heating System And Method For Occlusion Of The Fallopian Tube  
In a magnetic particle heating method for occlusion of the Fallopian tubes, biocompatible magnetic particles are delivered transcervically to the entrance of the Fallopian tube. Placement of the...
US20130122053 SYNTHETIC TRITERPENOIDS AND TRICYCLIC-BIS-ENONES FOR USE IN STIMULATING BONE AND CARTILAGE GROWTH  
The present invention concerns methods for stimulating the growth and repair of bone and cartilage using synthetic triterpenoids and tricyclic-bis-enones. Examples of suitable triterpenoids...
US20130115228 IMMUNOSTIMULATORY COMBINATIONS  
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
US20130108621 ANTI-CD154 ANTIBODIES HAVING IMPAIRED FcR BINDING AND/OR COMPLEMENT BINDING PROPERTIES AND THE USE THEREOF IN IMMUNE THERAPIES  
Improved anti-CD154 antibodies are provided herein which have ablated FcR binding. The use of these antibodies for inducing tolerance and treating immune diseases including autoimmunity,...
8433415 Apparatus and method for modulating neurochemical levels in the brain  
A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a...
US20130102527 INHIBITORS OF THE TRYPSIN-LIKE SITE OF THE PROTEASOME AND METHODS OF USE THEREOF  
The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an...
8424324 Refrigerant evaporators with pulse-electrothermal defrosting  
An pulse electro thermal defrost evaporator system has multiple refrigerant tubes formed from an electrically conductive metal and connected in parallel for refrigerant flow. These tubes are,...
US20130092678 System And Method For De-Icing Conductive Objects Utilizing At Least One Variable Resistance Conductor With High Frequency Excitation  
A conductor of a power transmission line has its effective resistance to flow of direct current or low-frequency current (such as, for example, 50 Hz or 60 Hz) varied in a wide range to pass...
8418484 Compact helical heat exchanger with stretch to maintain airflow  
A heat exchanger for exchanging heat between gasses such as air and a liquid or gaseous coolant has narrow spacing between exchanger surfaces for high efficiency. To avoid undue obstruction of gas...
US20130089526 Methods for Using Synthetic Triterpenoids in the Treatment of Bone or Cartilage Diseases or Conditions  
The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.
8417324 Fluorescence lifetime spectrometer (FLS) and methods of detecting diseased tissue  
This invention relates to method and apparatus for collection of the complete fluorescence emission spectrum and the transient decay of a selected spectral band simultaneously with data...
8416076 Magnetic proximity sensor system and associated methods of sensing a magnetic field  
A magnetic proximity sensor is attached to a ferrous object such that the sensor alerts a practitioner if a threshold of magnetic strength has been exceeded by bringing the ferrous object within a...
8415292 Compositions and methods for inhibiting the interaction between CFTR and CAL  
The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention...
8415154 Compositions and methods for producing adaptive regulatory T cells  
The present invention relates to a method for producing adaptive regulatory T cells from effector T cells by contacting the effector T cells with retinoic acid. Adaptive regulatory T cells...
8415109 Methods for diagnosing and treating neuroendocrine cancer  
The present invention relates to a method for diagnosing neuroendocrine cancers via detecting the presence of N-methyl D-asparate-associated (NMDA) glutamate receptors type 1 and/or type 2....
8414035 System and method for providing knot tying  
A knot tying system is presented containing a feeding mechanism, a knot tying device, and a clamp. The feeding mechanism has a drive roller and an idle roller capable of guiding a wire. A truck is...
US20130085263 METHOD FOR NON-COVALENT IMMOBILIZATION OF INFECTIOUS PRION PROTEIN  
The present invention is method for non-covalently immobilizing an infectious prion protein using a magnetic substrate.
8405002 Pulse electrothermal mold release icemaker with safety baffles for refrigerator  
An icemaker and a refrigerator having an icemaker are discussed. The icemaker has pulse-electrothermal ice release and includes an ice-making tray having several ice forming portions in which...