Patents and Patent Applications from Columbia University


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US20180054186 METHODS AND SYSTEMS FOR EVENT-DRIVEN RECURSIVE CONTINUOUS-TIME DIGITAL SIGNAL PROCESSING  
Continuous-time digital systems implemented with separate timing paths and data paths are disclosed. The disclosed continuous-time digital systems, can implement an event-grouping and detection...
US20180051337 PREDICTIVE VALUE OF COMBINED GENETIC ENZYMATIC AND LIPIDOMIC DATA IN DISEASE RISK FOR LEWY BODY DISEASE  
This present invention relates to genetic mutations that may be used to evaluate the risk of Lewy body disease in a subject. This invention is based, at least in part, on the discovery that...
US20180050982 USES OF HISTONE ACETYLTRANSFERASE ACTIVATORS  
The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically...
9896420 N-quinolin-benzensulfonamides and related compounds for the treatment of cancer, autoimmune disorders and inflammation  
The present invention relates to the NQBS class of molecules. It is based, at least in part, on the discovery that a representative group of compounds have been observed to inhibit nuclear...
9895301 Methods for treating hair loss disorders  
The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
US20180046755 ANALYZING HIGH DIMENSIONAL SINGLE CELL DATA USING THE T-DISTRIBUTED STOCHASTIC NEIGHBOR EMBEDDING ALGORITHM  
A method for mapping, graphing, and analyzing high-dimensional single cell data based on multiple parameters associated with the cell, including defining a point associated with the cell in a...
US20180046441 CODE RELATIVES DETECTION  
Disclosed are devices, systems, apparatus, methods, products, media, and other implementations, including a method that includes generating for a code segment of a first process an instruction...
US20180045717 SYSTEMS AND METHODS FOR SINGLE-MOLECULE NUCLEIC-ACID ASSAY PLATFORMS  
Integrated circuits for a single-molecule nucleic-acid assay platform, and methods for making such circuits are disclosed. In one example, a method includes transferring one or more carbon...
US20180042991 RECOMBINANT GLUT1 ADENO-ASSOCIATED VIRAL VECTOR CONSTRUCTS AND RELATED METHODS FOR RESTORING GLUT1 EXPRESSION  
The present invention relates to recombinant Glut1 adeno-associated viral vector (rAAV) constructs and related methods for restoring Glut1 expression in Glut1 deficient mammals. In certain...
US20180042970 Injectable Microtissue Systems, Devices, and Methods  
Spheroid microtissues that can mimic native tissue-like structure and function, spheroid production methods that are high-throughput, suitable for efficient production, maintainable over long-term...
9892518 Systems and methods for detecting motion using local phase information  
Systems and methods for the detection of motion in a multi-dimensional signal are provided. According to aspects of the disclosure, data representing a time sequence of frames of a video stream is...
9891182 Systems and methods for single-molecule detection using nanotubes  
A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is...
9890426 Pore-forming protein conjugate compositions and methods  
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as...
9890314 Using heat of solution of aluminum sulfate to store energy in tankless vacuum-tube solar water heaters  
The present invention generally relates to solar water heaters, in particular to solar water heaters using glass vacuum tubes as both solar energy collector and thermal energy storage device,...
9890136 Selective HDAC6 inhibitors  
The present invention provides a compound having the structure: whereinR1 is halogen, —NR5R6, —NR5—C(═O)—R6, —NH—C(═O)—OR7, —OR7, —NO2, —CN, —SR7, —SO2R7, —CO2R7, CF3, —SOR7, —POR7, —C(═S)R7,...
9888680 Functional recovery of human lungs for transplantation  
The vasculature of a donor lung is perfused with a lung preserving fluid to preserve its structure. At the same time, a decellularization fluid is perfused through the airways, which strips away...
9887862 Circuits and methods for performing self-interference cancelation in full-duplex transceivers  
Full duplex transceivers are provided, the transceivers comprising: a transmitter section that includes an analog portion having analog baseband signals and a digital portion having digital...
9887833 Systems and methods to counter side channel attacks  
Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes identifying a process to obtain timing information of a processor-based...
9885727 Cell culture models for validating candidate compounds for use in treating COPD and other diseases  
The present invention relates to methods of diagnosing, monitoring, and treating elastin fiber injuries. In additional preferred embodiments, the present invention relates to methods of validating...
US20180030546 Identification of a 5-Gene Expression Signature Predicting Clinical Outcome of Patients with Brain Tumors  
High-grade gliomas are the most common brain tumors in humans and are essentially incurable. The defining hallmark of these high-grade gliomas is the presence within the tumor mass of highly...
US20180030152 FUSION PROTEINS AND METHODS THEREOF  
The invention discloses oncogenic fusion proteins. The invention provides methods for treating gene-fusion based cancers.
US20180030060 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE  
The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5...
US20180028841 METHODS AND SYSTEMS FOR PERIPHERAL NERVE MODULATION USING FOCUSED ULTRASOUND  
Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one...
US20180028520 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS  
The present disclosure provides, inter alia, methods and pharmaceutical compositions for treating or ameliorating amyotrophic lateral sclerosis (ALS). Among the various aspects of the present...
US20180028493 INHIBITORS OF INDUCED MMP-1 PRODUCTION  
The present invention provides methods and compositions of prophylaxis for, or for treating, chronic obstructive pulmonary disease (COPD), cancer, arthritis, skin damage, or atherosclerotic plaque...
US20180028396 DEVICE AND METHODS FOR MASSAGE, ACUPRESSURE MYOFASCIAL RELEASE AND TRIGGER POINT THERAPY  
A device for self-administration of massage, trigger point therapy and/or myofascial release, and methods for same.
9880088 Force-clamp spectrometer with functionalized cantilever tip  
The disclosed subject matter relates to a force-clamp spectrometer that enables operation in constant force mode and allows for automated data acquisition and analysis, using feedback electronics...
9879020 GABAA agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma  
Novel methods of treating inflammation and airway constriction using GABAergic compounds with reduced benzo-diazepine-like CNS activity are provided. Novel compounds which selectively target...
US20180021273 HISTONE ACETYLTRANSFERASE ACTIVATORS AND COMPOSITIONS AND USES THEREOF  
The invention provides pharmaceutical compositions and methods for treating cancer, neurodegenerative disorders, conditions associated with accumulated amyloid-beta peptide deposits, Tau protein...
US20180021235 METHODS FOR TREATING HAIR LOSS DISORDERS  
The invention provides for methods for treating a hiar loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
9876490 Systems, apparatus, and methods for providing continuous-time signal differentiation and integration  
Systems and methods for providing an approximate differentiation and integration of an input continuous-time signal are provided. The disclosed systems include a continuous-time delay block...
US20180019123 Laser irradiation induced surface planarization of polycrystalline silicon films  
A method for planarizing excimer laser annealed (ELA) poly-crystalline thing films via irradiation. The method includes providing an ELA thin film having an oxide and a top surface with a first...
US20180016562 ANCESTRAL PROTEINS  
The invention provides a method tar increasing the stability and/or activity of a polypeptide at low pH and/or elevated temperatures The invention farther provides a method for increasing the...
9870014 Digital low drop-out regulator  
A regulator may comprise: an ADC unit for detecting a change in an output voltage and outputting an error code based on the detected result; a digital processing unit for generating a proportional...
9868985 Massive parallel method for decoding DNA and RNA  
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is...
9868730 Kappa opioid receptor selective compounds, compositions, and uses thereof  
The present invention provides, inter alia, compounds of formula (I): (structurally represented). Also provided are pharmaceutical compositions containing such compounds and methods for treating...
9867566 Technologies for white matter hyperintensity quantification  
A method comprises selecting, via a computer, an intensity threshold value. The method also comprises defining, via the computer, a plurality of hyperintensities on imaging data based on the...
US20180010136 Methods for Altering Polypeptide Expression  
The invention is directed to methods and metric suitable for use in modulating the expression of a polypeptide encoded by a nucleic acid sequence. In certain aspects, the invention also relates to...
9863979 Systems, apparatus, and methods for energy monitoring  
An apparatus for energy auditing can include a sensor portion on a circuit substrate, the sensor portion defining a first opening, an integrated inductor on the sensor portion, the integrated...
9862610 Methods and systems for the co-generation of gaseous fuels, biochar, and fertilizer from biomass and biogenic wastes  
Methods and systems for converting a biomass and biogenic wastes to hydrogen with integrated carbon dioxide capture and storage are disclosed. In some embodiments, the methods include the...
US20180002389 Compositions and Methods for Inhibiting Tumor Cells by Inhibiting the Transcription Factor ATF5  
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating...
9857168 Systems, methods, and media for performing shape measurement  
Systems, methods, and media for performing shape measurement are provided. In some embodiments, systems for performing shape measurement are provided, the systems comprising: a projector that...
9856281 Solid-state materials formed of molecular clusters and method of forming same  
A solid-state material comprising a solid-state compound is provided. The solid-state compound has the formula: [Cluster1][Cluster2]n, where Cluster1 can be a metal chalcogenide molecular cluster,...
US20170369779 METHODS OF PRODUCING METAL SULFIDES, METAL SELENIDES, AND METAL SULFIDES/SELENIDES HAVING CONTROLLED ARCHITECTURES USING KINETIC CONTROL  
The present invention is directed to methods of preparing metal sulfide, metal selenide, or metal sulfide/selenide nanoparticles and the products derived therefrom. In various embodiments, the...
US20170369472 MAP KINASE MODULATORS AND USES THEREOF  
The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further...
US20170368250 Wearable Ultrafiltration Devices Methods and Systems  
A wearable ultrafiltration apparatus is provided. The apparatus can include a first dialyzer for filtering a patient's blood along a first fluid path and a second dialyzer for filtering the...
US20170368244 DEVICES FOR INFANT FEEDING  
A system for infant feeding adapted to mimic an infant's mouthing and suckling during breastfeeding.
US20170368234 BIO-FILM RESISTANT SURFACES  
The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an antimicrobial agent, an organic hydroxy acid, lubricious...
9846313 Devices, apparatus and method for providing photostimulation and imaging of structures  
According to exemplary embodiments of the present disclosure, it is possible to provide method, system, arrangement, computer-accessible medium and device to stimulate individual neurons in brain...
US20170357808 SECURED CYBER-PHYSICAL SYSTEMS  
Disclosed are devices, systems, apparatus, methods, products, and other implementations, including a method that includes causing at least one reset for one or more components of a cyber-physical...