Patents and Patent Applications from Columbia University


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9999382 Measurement of a fluorescent analyte using tissue excitation  
An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring...
10002249 Systems, methods, and media for outputting data based on anomaly detection  
Systems, methods, and media for outputting data based on anomaly detection are provided. In some embodiments, a method for outputting data based on anomaly detection is provided, the method...
10000801 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators  
This invention provides a process for sequencing single-stranded DNA employing modified nucleotides.
US20180164657 OPTICAL QUANTIFICATION OF INTERFACIAL CHARGE STATES  
Methods of generating second harmonic generation (SHG) signals from interfaces formed with, or formed over, a noncentrosymmetric material, e.g., α-quartz, are provided. The methods make use of the...
9996743 Methods, systems, and media for detecting gaze locking  
Methods, systems, and media for detecting gaze locking are provided. In some embodiments, methods for gaze locking are provided, the methods comprising: receiving an input image including a face;...
9996694 Unsupervised detection of anomalous processes using hardware features  
Disclosed are devices, systems, apparatus, methods, products, media and other implementations, including a method that includes obtaining current hardware performance data, including hardware...
9994961 Electrocatalyst for hydrogen evolution and oxidation reactions  
A metallic alloy includes Cu and one or more metals M selected from the group consisting of Ti, V, Cr, Mn, Fe, Co, Ni and Zn, wherein the alloy has a surface in the form of a vermiculated...
US20180156746 SYSTEMS AND METHODS FOR SINGLE-MOLECULE DETECTION USING NANOTUBES  
A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is...
US20180154339 COMPOSITE FILAMENTS HAVING THIN CLADDINGS, ARRAYS OF COMPOSITE FILAMENTS, FABRICATION AND APPLICATIONS THEREOF  
A method of fabricating composite filaments is provided. An initial composite filament including a core and a cladding (such as a Pt-group metal) is cut into smaller pieces (or is first...
US20180153177 BOTANICAL ANTIMICROBIAL COMPOSITIONS  
Disclosed herein are antimicrobial compositions comprising mixtures of botanical extracts, synthetic antimicrobial agents and essential oils which do not rely solely upon alcohol to produce their...
9992222 Systems and methods for inhibiting attacks with a network  
Systems and methods for inhibiting attacks with a network are provided. In some embodiments, methods for inhibiting attacks by forwarding packets through a plurality of intermediate nodes when...
9988606 Generation of airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres  
Embodiments of the present invention are directed to various methods for generating airway and lung progenitors and epithelial cells and three-dimensional anterior foregut spheres, and to...
9988377 Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders  
This invention provides a compound having the structure whereinA is a ring structure, with or without substitution;Z is present or absent and when present is whereinn is 0, 1, 2, 3, or 4;Y is...
9981069 Bio-film resistant surfaces  
The present invention relates to methods and compositions for rendering a surface resistant to bio-film formation by a combination of an alkanediol and an antimicrobial agent (and, optionally, an...
9981025 Anti-drug vaccines  
The present invention relates to anti-drug vaccines based on conjugates between the drug and a non-immunogenic carrier protein. In preferred embodiments, it provides for anti-cocaine vaccines and...
US20180143374 PHOTONICS INTERPOSER OPTOELECTRONICS  
In one embodiment an optoelectronic system can include a photonics interposer having a substrate and a functional interposer structure formed on the substrate, a plurality of through vias carrying...
US20180140871 SYSTEMS AND METHODS FOR MODULATION AND MAPPING OF BRAIN TISSUE USING AN ULTRASOUND ASSEMBLY  
Methods and systems for modulation and mapping of brain tissue in a subject using an ultrasound assembly are provided. An exemplary method for modulation uses an ultrasound assembly including a...
US20180140724 Tumor Deliverable Iron and Protein Synthesis Inhibitors as a New Class of Drugs for the Diagnosis and Treatment of Cancer  
Tumor deliverable iron (TDI) drugs and pharmaceutical compositions and kits comprising them are provided and methods for delivering iron to tumors specifically, either intracellularly or...
9974782 Phosphodiesterase inhibitors and uses thereof  
The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase...
US20180138918 SYSTEMS AND METHODS FOR DELAY-BASED CONTINUOUS TIME PROCESSING  
Disclosed herein are some continuous time systems and methods. Some of the disclosed systems and methods use a continuous-time analog-to-digital converter (ADC) configured to receive an analog...
US20180135121 PORE-FORMING PROTEIN CONJUGATE COMPOSITIONS AND METHODS  
The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as...
US20180133333 BIODEGRADABLE THERMO-RESPONSIVE POLYMERS AND USES THEREOF  
The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical...
US20180133241 DEOXYNUCLEOSIDE THERAPY FOR DISEASES CAUSED BY UNBALANCED NUCLEOTIDE POOLS INCLUDING MITOCHONDRIAL DNA DEPLETION SYNDROMES  
The invention relates generally to a pharmacological therapy for human genetic diseases, specifically those characterized by unbalance nucleotide pools, more specifically mitochondrial DNA...
9971891 Methods, systems, and media for detecting covert malware  
Methods, systems, and media for detecting covert malware are provided. In accordance with some embodiments, a method for detecting covert malware in a computing environment is provided, the method...
9969677 Histone acetyltransferase modulators and uses thereof  
The invention provides compounds and compositions comprising compounds that modulate histone acyl transferase (HAT). The invention further provides methods for treating neurodegenerative...
9968101 Botanical antimicrobial compositions  
Disclosed are compositions comprising antimicrobially effective low concentrations of benzyl alcohol, one or more essential oil and one or more botanical extract. The compositions of the...
US20180126191 METHODS FOR REDUCING INFLAMMATION WITH SURFACE ACOUSTIC WAVES  
Disclosed herein is a method of reducing inflammation in a patient with a chronic condition, such as Parkinson's disease or Alzheimer's disease. The method includes applying surface acoustic waves...
9967115 Circuits and methods for spatial equalization of in-band signals in MIMO receivers  
A circuit for spatial equalization, comprising: circuit elements each comprising four variable transconductors, in each of the circuit elements: an input of a first variable transconductor (VT) is...
US20180124081 SYSTEM AND METHODS FOR DETECTING MALICIOUS EMAIL TRANSMISSION  
A system and methods of detecting an occurrence of a violation of an email security policy of a computer system. A model relating to the transmission of prior emails through the computer system is...
US20180122848 SYSTEMS AND METHODS FOR IMAGING USING SINGLE PHOTON AVALANCHE DIODES  
Single-photon avalanche diode includes a central junction having a central p+ area and a deep-n well in contact with the central p+ area, a p-type guard ring disposed between the central junction...
US20180118709 SELECTIVE HDAC6 INHIBITORS  
The present invention provides a compound having the structure: whereinR1 is halogen, —NR5R6, —NR5—C(═O)—R6, —NH—C(═O)—OR7, —OR7, —NO2, —CN, —SR7, —SO2R7, —CO2R7, CF3, —SOR7, —POR7, —C(═S)R7,...
US20180118699 SK AND IK CHANNEL AGONISTS FOR TREATMENT OF HEART FAILURE  
The present invention provides compounds that are improved potassium channel agonists. Pharmaceutical compositions including a pharmaceutically acceptable carrier and a compound of the present...
9960734 Systems and methods for graphene mechanical oscillators with tunable frequencies  
A nano-electro-mechanical systems (NEMS) oscillator can include an insulating substrate, a source electrode and a drain electrode, a metal local gate electrode, and a micron-sized, atomically thin...
9958436 Determination of cell chirality  
Methods for determining cell chirality using micropatterned substrates are disclosed. Also provided are methods for diagnosing diseases such as genetic diseases or cancer by comparing the...
US20180112257 POLYMER TAGGED NUCLEOTIDES FOR SINGLE MOLECULE ELECTRONIC SNP ASSAY  
This invention provides methods of using labeled nucleotide polyphosphate analogues to detect the identity or presence of a nucleotide at certain positions in nucleic acid sequences with single...
US20180110879 SMOOTH MUSCLE SPECIFIC INHIBITION FOR ANTI-RESTENOTIC THERAPY  
The present invention provides for the incorporation of target sequences of microRNAs into the 3′UTR region of a gene of interest in nucleic acid vectors. The invention also provides for an...
9954497 Circuits for low noise amplifiers with interferer reflecting loops  
Circuits for low noise amplifiers with interferer reflecting loops are provided. In some embodiments, circuits for a low noise amplifier with an interferer reflecting loop are provided, the...
9951330 Micrornas that silence tau expression  
This invention relates to the treatment and prevention of Alzheimer's disease (AD), tangle-predominant dementia (TPD) and other diseases associated with abnormal tau expression, e.g., tauopathies,...
9951311 Agents and methods to elicit anti-tumor immune response  
The invention provides an isolated, purified population of human cells comprising CD8+ T cells with reduced Cbl-b activity. The invention provides uses of such cells in methods for inducing or...
US20180109843 METHODS AND SYSTEMS FOR AGGREGATION AND ORGANIZATION OF MULTIMEDIA DATA ACQUIRED FROM A PLURALITY OF SOURCES  
A system for aggregation and organization of multimedia data acquired from a plurality of sources can include a data collection element, a multimedia segmentation element, a memory, an extraction...
US20180106692 Systems And Methods For Tactile Sensing  
Achieving high spatial resolution in contact sensing for robotic manipulation often comes at the price of increased complexity in fabrication and integration. One traditional approach is to...
US20180105565 Compositions and Methods for Inhibiting Tumor Cells by Inhibiting the Transcription Factor ATF5  
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating...
9944644 Octahydropyrrolopyrroles their preparation and use  
The present invention provides compounds comprising variously substituted octahydropyrrolopyrroles, their synthesis, methods of making, methods of using, compositions and formulations thereof.
9944541 System for cleansing organisms from water  
Techniques for depleting target organisms in water include a waterproof transducer configured for ensonifying a container of water with low intensity sound at one or more ultrasound frequencies...
9943626 Core-centered granule composed of micro-structure body  
A granule form e d from a tubular body having an outer surface and an inner surface separated by a matrix, and at least one core defining an opening extending through the tubular body. The outer...
9938291 N-alkyl-2-phenoxyethanamines, their preparation and use  
The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is...
9938245 Carbonyl erastin analogs and their use  
The present invention provides, inter alia, compounds having the structure of formula (I): Compositions containing such compounds are also provided. Methods for using such compounds or...
US20180094322 Biomarker for Predicting Colon Cancer Responsiveness to Anti-Tumor Treatment  
The present invention provides a biomarker, namely CDX2, and surrogate CDX2 biomarkers, the expression level of which is useful in predicting response of cancer patients to therapy with an EGFR...
US20180092908 SMALL MOLECULE OXIDIZERS OF PDI AND THEIR USE  
The present invention provides a method for treating or ameliorating the effects of a neurodegenerative disorder in a subject in need thereof. The method includes, for example, administering to...
US20180085493 SPATIOTEMPORAL DELIVERY SYSTEM EMBEDDED IN 3D-PRINTING  
Provided herein is a 3D printing system and related compositions, and method of using such, that can produce a polymeric microfiber having embedded microspheres encapsulating an active agent with...