Patents and Patent Applications from Columbia University


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US20170294629 LIGHT EMISSION FROM ELECTRICALLY BIASED GRAPHENE  
Methods and systems for emitting light from electrically biased graphene are provided. An exemplary method of generating a light emission from graphene includes suspending a graphene membrane...
US20170294608 SELF-ASSEMBLED, ELECTRONICALLY-FUNCTIONAL NUCLEIC ACID NANOSTRUCTURES AND NETWORKS BASED ON THE USE OF ORTHOGONAL BASE PAIRS  
Methods and systems for engineering a nanostructure are provided. An exemplary method includes creating at least one cytosine-cytosine and/or thymine-thymine mismatch in at least one...
US20170290849 AKT and SHH Pathway Inhibitor Combination Therapy for Treating Basal Cell Carcinomas  
A mechanism whereby aberrant Shh signaling converges on the Akt1-mTOR pathway, conferring selective growth advantage and enhanced survival of tumor cells has been identified. Utilizing a mouse...
US20170290665 METHOD OF MAKING A PERSONALIZED BONE GRAFT  
An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target...
9788060 Methods and systems for aggregation and organization of multimedia data acquired from a plurality of sources  
A system for aggregation and organization of multimedia data acquired from a plurality of sources can include a data collection element, a multimedia segmentation element, a memory, an extraction...
9783580 Treatment and prevention of Gardnerella vaginalis infections  
The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The...
9783525 Map kinase modulators and uses thereof  
The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further...
US20170284787 SYSTEMS AND METHODS FOR CONTACT LOCALIZATION THROUGH SPATIALLY OVERLAPPING SIGNALS  
Achieving high spatial resolution in contact sensing for robotic manipulation often comes at the price of increased complexity in fabrication and integration. One traditional approach is to...
US20170283859 MICROFLUIDIC qRT-PCR ANALYSIS OF SINGLE CELLS  
The disclosed subject matter provides a microdevice and techniques for single-cell gene expression profiling using a microfluidic device capable of cell-trapping, cell lysis, bead-based gene...
US20170283810 Nucleic acid constructs for presentation of CD4 and CD8 epitopes, cellular transfection and uses thereof  
The invention relates to constructs, cells and methods for modulating the immune system that optimize presentation of CD4 and CD8 epitopes to antigen-presenting cells and transfection into cells....
US20170283451 DNA SEQUENCING BY SYNTHESIS USING RAMA AND IFRARED SPECTROSCOPY DETECTION  
This invention provides a process of labeling a polynucleotide analogue to be detected by Raman and/or infrared spectroscopy detection.
US20170281772 A NEURAL SUBSTRATE FOR SUGAR PREFERENCE  
This invention concerns a composition and a method of modulating the craving and/or desire for natural sugar in a subject comprising: agonizing or stimulating or antagonizing or silencing a...
9778113 Ultracompact fabry-perot array for ultracompact hyperspectral imaging  
Techniques for hyperspectral imaging, including a device for hyperspectral imaging including at least one tunable interferometer including a thin layer of material disposed between two or more...
9777010 Substituted 4-phenylpiperidines, their preparation and use  
The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5...
9776963 Small molecule CD4 mimetics and uses thereof  
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl,...
US20170279557 RESILIENT OPTICAL NETWORKING  
An optical communication system includes a plurality of optical system nodes, a plurality of optical space switches and a plurality of optical fibers. The plurality of optical system nodes each...
US20170277889 Systems, Methods, and Media for Outputting a Dataset Based Upon Anomaly Detection  
Systems, methods, and media for outputting a dataset based upon anomaly detection are provided. In some embodiments, methods for outputting a dataset based upon anomaly detection: receive a...
US20170275585 CELLULAR RESPONSE TO SURFACE WITH NANOSCALE HETEROGENEOUS RIGIDITY  
An elastomeric substrate comprises a surface with regions of heterogeneous rigidity, wherein the regions are formed by exposing the elastomeric substrate to an energy source to form the regions...
9771562 Method for culture of human and mouse prostate organoids and uses thereof  
The invention discloses a methodology for the culture of prostate tissue organoids from mouse and human prostate.
9771430 Method of treating a metabolic disorder induced by obesity in a subject in need thereof by administering MK2/3 inhibitors  
The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic...
9766867 Systems and methods for improving performance of mobile applications  
Systems and methods for improving the performance of mobile applications are disclosed. An exemplary method can include receiving a request for the application, where the request can include...
9765297 Stem cell-based culture system for drug development  
The present invention relates to culture systems comprising differentiated stem cells, that may be used for identifying agents useful in treating degenerative nervous system disorders and are...
9763866 Methods for treating hair loss disorders  
The invention provides for methods for treating a hair loss disorder in a subject by administering a Janus Kinase/Signal Transducers and Activators of Transcription inhibitor.
US20170264672 METHODS, SYSTEMS, AND MEDIA FOR STORED CONTENT DISTRIBUTION AND ACCESS  
Methods for distributing and providing access to stored content from remote storage comprising: receiving a first request to access a first portion of stored content from a requestor, wherein the...
US20170260509 Systems, Methods, and Devices for Cell Cycle Synchronization of Stem Cells  
The present disclosure relates to methods and systems of tissue engineering, and, more particularly, to optimization of tissue regeneration using cell cycle synchronization of stem cells.
US20170258786 RBP4 ANTAGONISTS FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE  
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in a mammal afflicted therewith, comprising administering to the mammal an effective amount of a...
9762273 Circuits and methods for detecting interferers  
Mechanisms for interferer detection can detect interferers by detecting elevated signal amplitudes in one or more of a plurality of bins (or bands) in a frequency range between a maximum frequency...
9759842 Functionalized surfaces and methods related thereto  
The disclosed subject matter provides a nanoaperture having a bottom surface and a side wall comprising gold. A surface of the side wall is passivated with a first functional molecule comprising...
9758606 Cyclopropenium polymers and methods for making the same  
The present invention provides, inter alia, a process for incorporating a cyclopropenium ion into a polymeric system. Processes for making cross-linked polymers, linear polymers, and dendritic...
9758556 Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5  
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating...
9758555 Compositions and methods for inhibiting tumor cells by inhibiting the transcription factor ATF5  
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating...
US20170255258 Imperceptible Automatic Field-of-View Restrictors to Combat VR Sickness and Cybersickness  
The present disclosure provides an eye-tracked field of view restrictor for a virtual reality, augmented reality, and/or mixed reality system that reduces the effects of virtual reality sickness...
9755680 Circuits for field-programmable receiver front ends  
Circuits for field-programmable receiver front ends are provided. These front ends can include a field programmable common source low noise transconductance amplifier (LNTA), a field programmable...
9755590 Circuits for low noise amplifiers  
Low noise amplifiers (LNAs) are provided, the LNAs comprising: a common gate matching network; a capacitord; a resistord; a coild, wherein a side1 of coild is coupled to a side1 of capacitord, a...
9752869 Systems and methods for performing machine vision using diffuse structured light  
Systems for performing machine vision using diffuse structured light comprising: a linear diffuser having an axis of diffusion; a light source that projects an illumination pattern through the...
9750789 Use of matrix metalloproteinase inhibitors to treat tuberculosis  
The present invention provides a method for treating a subject suffering from tuberculosis which comprises administering to the subject a composition comprising an amount of an inhibitor of a...
US20170250024 Rare-Earth-Free Permanent Magnetic Materials Based on Fe-Ni  
The invention provides high coercivity magnetic materials based on FeNi alloys having an L10 phase structure, and methods for making the materials.
US20170247327 OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE  
The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4,...
US20170246339 NOVEL HEMOSTATIC COMPOSITIONS AND DRESSINGS FOR BLEEDING  
The present invention provides hemostatic compositions comprising components of the flowers of pharmaceutical chamomile (Chamomilla recutita), the leaves of dioecious nettle (Urtica dioica),...
US20170246267 CHOLINERGIC ANTAGONISM AS AN ADJUNCT TO CANCER THERAPY  
The invention provides for methods for treating gastric cancer or colon cancer in a subject by administering a cholinergic antagonist, a Botulinum toxin, a NGF inhibitior, a TRK inhibitor, or...
US20170246173 Methods and Pharmaceutical Compositions for Treating Lymphoid Malignancy  
The present invention provides, inter alia, methods for treating, preventing, or ameliorating the effects of a lymphoid malignancy, such as those associated with a mutated phosphatase and tensin...
9746463 Undercarboxylated/uncarboxylated osteocalcin increases beta-cell proliferation, insulin secretion, insulin sensitivity, glucose tolerance and decreases fat mass  
The present invention relates to methods and compositions for treating and diagnosing disorders related to energy metabolism and the OST-PTP signaling pathway involving gamma-carboxylase,...
9745601 Methods and systems for producing products using engineered sulfur oxidizing bacteria  
Methods and systems for producing a biofuel using genetically modified sulfur-oxidizing and iron-reducing bacteria (SOIRB) are disclosed. In some embodiments, the methods include the following:...
9744236 Photolabile compounds  
The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is...
US20170245290 METHOD, COMPUTER-READABLE STORAGE DEVICE, AND APPARATUS FOR ALLOCATING TIMESLOTS ON CHANNELS IN A WIRELESS NETWORK  
A method, computer-readable storage device, and apparatus for allocating a plurality of timeslots of each channel of a plurality of channels in a wireless network are disclosed. For example, the...
US20170243002 DETECTING RETURN-ORIENTED PROGRAMMING PAYLOADS BY EVALUATING DATA FOR A GADGET ADDRESS SPACE ADDRESS AND DETERMINING WHETHER OPERATIONS ASSOCIATED WITH INSTRUCTIONS BEGINNING AT THE ADDRESS INDICATE A RETURN-ORIENTED PROGRAMMING PAYLOAD  
Systems, methods, and media for detecting the presence of return-oriented programming (ROP) payloads are provided, comprising: identifying a potential gadget address space; determining if a piece...
US20170241948 NUCLEIC ACID SEQUENCES USING TAGS  
This disclosure provides chips, systems and methods for sequencing a nucleic acid sample. Tagged nucleotides are provided into a reaction chamber comprising a nanopore in a membrane. An individual...
US20170240606 Compositions and Methods for Inhibiting Tumor Cells by Inhibiting the Transcription Factor ATF5  
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating...
US20170240605 COMPOSITIONS AND METHODS FOR INHIBITING TUMOR CELLS BY INHIBITING THE TRANSCRIPTION FACTOR ATF5  
The present invention relates to methods for treating and/or preventing tumors and/or promoting apoptosis in a neoplastic cell comprising contacting the neoplastic cell with an cell-penetrating...
9741870 Systems and methods for CMOS-integrated junction field effect transistors for dense and low-noise bioelectronic platforms  
A complementary metal oxide semiconductor (CMOS)-integrated junction field effect transistor (JFET) has reduced scale and reduced noise. An exemplary JFET has a substrate layer of one dopant type...