Patents and Patent Applications from Columbia University


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US20170351026 Integrated Micro-Lens Waveguide And Methods Of Making And Using Same  
A probe structure includes a monolithically integrated waveguide and lens. The probe is based on SU-8 as a guiding material. A waveguide mold is defined using wet etching of silicon using a...
US20170350882 GRAPHENE-BASED NANOSENSOR FOR IDENTIFYING TARGET ANALYTES  
A microdevice for monitoring a target analyte is provided. The microdevice can include a field effect transistor comprising a substrate, a gate electrode, and a microfluidic channel including...
US20170350837 SYSTEMS AND METHODS FOR SINGLE-MOLECULE DETECTION USING NANOTUBES  
A method for single-molecule detection is provided and uses a carbon nanotube having a probe entity attached thereto to define a first state of the carbon nanotube. The carbon nanotube is...
9831360 Integrated thermal stabilization of a microring resonator  
Embodiments of the present disclosure provide devices and methods involving the thermal stabilization of microring resonators, such as microring modulators. Power is measured via an on-chip...
9831283 Systems and methods for imaging using single photon avalanche diodes  
Single-photon avalanche diode includes a central junction having a central p+ area and a deep-n well in contact with the central p+ area, a p-type guard ring disposed between the central junction...
9830176 Methods, systems, and media for binary compatible graphics support in mobile operating systems  
Methods, systems, and media for binary compatible graphics support in mobile operating systems are provided. In some embodiments, binary compatible graphics support can be provided by extending...
US20170336407 DETECTION OF ANALYTES USING LIVE CELLS  
The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection...
US20170335283 Osteochondroreticular Stem Cells for Bone and Cartilage Regeneration  
The invention is directed to osteochondroreticular stem cells and methods of using osteochondroreticular stem cells. In another aspect the invention is directed to a method of treating...
US20170334923 OPIOID RECEPTOR MODULATORS  
The present invention provides a compound having the structure wherein A is a ring structure, with or without substitution; X1 is C or N; X2 is N, O, or S; Y1 is H, -(alkyi), -(alkenyl),...
US20170333840 METHODS AND SYSTEMS FOR CAPTURING AND STORING CARBON DIOXIDE  
Methods and systems for capturing and storing carbon dioxide are disclosed. In some embodiments, the methods include the following: mixing materials including magnesium or calcium with one or more...
US20170333597 ENGINEERING MECHANICALLY FUNCTIONAL HUMAN CARTILAGE AND METHOD OF MAKING SAME  
Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.
9822161 ILT3 polypeptides and uses thereof  
This invention provides a method for inhibiting the rejection of transplanted islet cells, comprising administering to the subject a polypeptide comprising all or a portion of the extracellular...
US20170331467 SYSTEMS, APPARATUS, AND METHODS FOR PROVIDING CONTINUOUS-TIME SIGNAL DIFFERENTIATION AND INTEGRATION  
The disclosed subject matter includes an apparatus. The apparatus is configured to provide an approximate differentiation of an input continuous-time signal. The apparatus includes a...
US20170328917 AUTISM-ASSOCIATED BIOMARKERS AND USES THEREOF  
The invention discloses biomarkers for human autism. The invention provides methods for treating, preventing, and diagnosing human autism and autism-related disorders.
US20170327591 Diagnosis and Treatment of Cancer Expressing ILT3 or ILT3 Ligand  
The present invention relates to methods of using the expression of ILTL3 ligand or ILT3 on certain types of cancer cells as a diagnostic tool. Methods are provided for treating ILT3-ligand...
US20170326179 COMPOSITIONS AND METHODS FOR INHIBITION OF LINEAGE SPECIFIC ANTIGENS  
Disclosed herein are methods of administering an agent targeting a lineage-specific cell-surface antigen and a population of hematopoietic cells that are deficient in the lineage-specific...
US20170323096 METHODS, MEDIA, AND SYSTEMS FOR DETECTING ATTACK ON A DIGITAL PROCESSING DEVICE  
Methods, media, and systems for detecting attack are provided. In some embodiments, the methods include: comparing at least part of a document to a static detection model; determining whether...
US20170321281 METHODS AND COMPOSITIONS FOR TREATMENT OF GLIOBLASTOMA  
Techniques for treating a subject with M-GBM and recurrent GBM are provided. Example methods include obtaining at least two M-GBM tumor samples from different locations within a patient,...
US20170321267 DESIGN AND SYNTHESIS OF CLEAVABLE FLUORESCENT NUCLEOTIDES AS REVERSIBLE TERMINATORS FOR DNA SEQUENCING BY SYNTHESIS  
This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.
US20170319660 OSTEOCALCIN AS A TREATMENT FOR FRAILTY ASSOCIATED WITH AGING  
Methods and compositions for treating frailty in mammals, preferably humans, are provided. The methods generally involve modulation of the OST-PTP signaling pathway or the PTP-1B signaling pathway...
US20170319584 ALDOSE REDUCTASE INHIBITORS AND USES THEREOF  
The present invention relates to novel compounds and pharmaceutical compositions thereof, and methods for promoting healthy aging of skin, the treatment of skin disorders, the treatment of...
US20170319171 Devices, Methods, and Systems for Measuring Elastic Properties of Biological Tissues Using Acoustic Force  
A device, method, and system for using an acoustic radiation force resulting from focused ultrasound energy in order to generate an internal force remotely and to measure quantitatively tissue...
9809532 Uses of histone acetyltransferase activators  
The invention provides methods for enhancing histone acylation, learning, memory and/or cognition in subjects with compound (I) or compositions comprising compound (I), or a pharmaceutically...
9808557 Tubular silk compositions and methods of use thereof  
Described are tubular silk fibroin compositions and methods for their manufacture and use. Tubular compositions as described herein can be produced in a range of high burst strengths, can easily...
US20170317684 WIRELESS-TRANSMITTER CIRCUITS INCLUDING POWER DIGITAL-TO-AMPLITUDE CONVERTERS  
Circuits comprising: digital-to-amplitude converter (DAC), comprising: binary weighted switching transistors (BWSTs), each having gate coupled to amplitude control bit ACB, and wherein the drain...
US20170317219 SYSTEMS AND METHODS FOR CMOS-INTEGRATED JUNCTION FIELD EFFECT TRANSISTORS FOR DENSE AND LOW-NOISE BIOELECTRONIC PLATFORMS  
A complementary metal oxide semiconductor (CMOS)-integrated junction field effect transistor (JFET) has reduced scale and reduced noise. An exemplary JFET has a substrate layer of one dopant type...
US20170313737 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA  
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue...
US20170307553 MEMS-BASED CALORIMETER, FABRICATION, AND USE THEREOF  
A MEMS-based calorimeter includes a reference channel, a sample channel, and a thermopile configured to measure a temperature differential between the reference channel and a sample channel. The...
US20170306006 HUMAN NOTCH1 DECOYS  
Provided herein are Notch1 fusion proteins. These fusion proteins comprise consecutive amino acids the sequence of which, commencing at the N-terminus of the fusion protein, is identical to the...
US20170294629 LIGHT EMISSION FROM ELECTRICALLY BIASED GRAPHENE  
Methods and systems for emitting light from electrically biased graphene are provided. An exemplary method of generating a light emission from graphene includes suspending a graphene membrane...
US20170294608 SELF-ASSEMBLED, ELECTRONICALLY-FUNCTIONAL NUCLEIC ACID NANOSTRUCTURES AND NETWORKS BASED ON THE USE OF ORTHOGONAL BASE PAIRS  
Methods and systems for engineering a nanostructure are provided. An exemplary method includes creating at least one cytosine-cytosine and/or thymine-thymine mismatch in at least one...
US20170290849 AKT and SHH Pathway Inhibitor Combination Therapy for Treating Basal Cell Carcinomas  
A mechanism whereby aberrant Shh signaling converges on the Akt1-mTOR pathway, conferring selective growth advantage and enhanced survival of tumor cells has been identified. Utilizing a mouse...
US20170290665 METHOD OF MAKING A PERSONALIZED BONE GRAFT  
An anatomically-shaped, human bone graft may be cultivated ex vivo using a bioreactor capable of perfusing large complex porous scaffolds. Scaffolds derived from image-based modeling of a target...
9788060 Methods and systems for aggregation and organization of multimedia data acquired from a plurality of sources  
A system for aggregation and organization of multimedia data acquired from a plurality of sources can include a data collection element, a multimedia segmentation element, a memory, an extraction...
9783580 Treatment and prevention of Gardnerella vaginalis infections  
The present invention is drawn to the nucleic and amino acid sequences encoding vaginolysin (VLY) toxin from Gardnerella vaginalis, and biologically active fragments and variants thereof. The...
9783525 Map kinase modulators and uses thereof  
The invention provides for novel MAP kinase inhibitors and compositions comprising the same. In some embodiments, the MAP kinase inhibitors are p38α MAP kinase inhibitors. The invention further...
US20170284787 SYSTEMS AND METHODS FOR CONTACT LOCALIZATION THROUGH SPATIALLY OVERLAPPING SIGNALS  
Achieving high spatial resolution in contact sensing for robotic manipulation often comes at the price of increased complexity in fabrication and integration. One traditional approach is to...
US20170283859 MICROFLUIDIC qRT-PCR ANALYSIS OF SINGLE CELLS  
The disclosed subject matter provides a microdevice and techniques for single-cell gene expression profiling using a microfluidic device capable of cell-trapping, cell lysis, bead-based gene...
US20170283810 Nucleic acid constructs for presentation of CD4 and CD8 epitopes, cellular transfection and uses thereof  
The invention relates to constructs, cells and methods for modulating the immune system that optimize presentation of CD4 and CD8 epitopes to antigen-presenting cells and transfection into cells....
US20170283451 DNA SEQUENCING BY SYNTHESIS USING RAMA AND IFRARED SPECTROSCOPY DETECTION  
This invention provides a process of labeling a polynucleotide analogue to be detected by Raman and/or infrared spectroscopy detection.
US20170281772 A NEURAL SUBSTRATE FOR SUGAR PREFERENCE  
This invention concerns a composition and a method of modulating the craving and/or desire for natural sugar in a subject comprising: agonizing or stimulating or antagonizing or silencing a...
9778113 Ultracompact fabry-perot array for ultracompact hyperspectral imaging  
Techniques for hyperspectral imaging, including a device for hyperspectral imaging including at least one tunable interferometer including a thin layer of material disposed between two or more...
9777010 Substituted 4-phenylpiperidines, their preparation and use  
The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5...
9776963 Small molecule CD4 mimetics and uses thereof  
The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl,...
US20170279557 RESILIENT OPTICAL NETWORKING  
An optical communication system includes a plurality of optical system nodes, a plurality of optical space switches and a plurality of optical fibers. The plurality of optical system nodes each...
US20170277889 Systems, Methods, and Media for Outputting a Dataset Based Upon Anomaly Detection  
Systems, methods, and media for outputting a dataset based upon anomaly detection are provided. In some embodiments, methods for outputting a dataset based upon anomaly detection: receive a...
US20170275585 CELLULAR RESPONSE TO SURFACE WITH NANOSCALE HETEROGENEOUS RIGIDITY  
An elastomeric substrate comprises a surface with regions of heterogeneous rigidity, wherein the regions are formed by exposing the elastomeric substrate to an energy source to form the regions...
9771562 Method for culture of human and mouse prostate organoids and uses thereof  
The invention discloses a methodology for the culture of prostate tissue organoids from mouse and human prostate.
9771430 Method of treating a metabolic disorder induced by obesity in a subject in need thereof by administering MK2/3 inhibitors  
The present invention relates to methods of treating or preventing a metabolic disorder in a subject, methods of treating or preventing coronary artery disease in a subject with a metabolic...
9766867 Systems and methods for improving performance of mobile applications  
Systems and methods for improving the performance of mobile applications are disclosed. An exemplary method can include receiving a request for the application, where the request can include...