Patents and Patent Applications from Columbia University


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US20090298864 Methods for Treating Mild Cognitive Impairment  
The present invention relates to compounds, compositions, and methods useful for: (i) treating or preventing mild cognitive impairment, or (ii) delaying the progression from mild cognitive...
US20090298072 DNA Sequencing by Nanopore Using Modified Nucleotides  
This invention provides a process for sequencing single-stranded DNA by employing a nanopore and modified nucleotides.
US20090297847 GROWTH AND APPLICATIONS OF ULTRALONG CARBON NANOTUBES  
Ultralong carbon nanotubes can be formed by placing a secondary chamber within a reactor chamber to restrict a flow to provide a laminar flow. Inner shells can be successively extracted from...
US20090297626 Methods for preparing metal oxides  
The disclosed subject matter provides a method for preparing a metal oxide, the method includes (a) contacting a metal salt precursor with an alcohol to provide a metal oxide; and (b) removing the...
US20090292119 METHODS FOR SYNTHESIZING BENZOTHIAZEPINE COMPOUNDS  
The present invention provides improved methods for synthesizing novel benzothiazepine compounds. In particular, the invention relates to a new method that generally is used to make the substituted...
7622370 Process and system for laser crystallization processing of film regions on a substrate to minimize edge areas, and a structure of such film regions  
A process and system for processing a thin film sample are provided. In particular, a beam generator can be controlled to emit at least one beam pulse. The beam pulse is then masked to produce at...
7622279 Photocleavable fluorescent nucleotides for DNA sequencing on chip constructed by site-specific coupling chemistry  
This invention provides a method for determining the sequence of a DNA or an RNA, wherein (i) about 1000 or fewer copies of the DNA or RNA are bound to a solid substrate via 1,3-dipolar...
7619656 Systems and methods for de-blurring motion blurred images  
Systems and methods for providing a substantially de-blurred image of a scene from a motion blurred image of the scene are disclosed. An exemplary system includes a primary detector for sensing the...
US20090280491 PREDICTING CANCER INVASIVENESS  
Provided are methods of determining the likelihood of a human cancer being invasive. Also provided are methods of determining whether a lung adenocarcinoma is a bronchioloalveolar carcinoma (BAC)....
US20090280109 ILT3 and ILT4-related compositions and methods  
This invention provides compositions which comprise at least two of a CD4+CD25+ cell, IL-10, a CD8+CD28− cell and a vitamin D3 analog. This invention also provides methods for generating a t...
7615554 Erastin and erastin binding proteins, and uses thereof  
The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also...
7614748 Systems and methods for displaying three-dimensional images  
Systems and methods for displaying three-dimensional (3D) images are described. In particular, the systems can include a display block made from a transparent material with optical elements...
US20090275636 PICORNAVIRUS AND USES THEREOF  
The invention is directed to a a clade of newly isolated and identified picornaviruses associated with respiratory infection, and isolated nucleic acids sequences and peptides thereof. The...
US20090274739 METHODS AND COMPOSITIONS FOR TREATING NEOINTIMAL HYPERPLASIA  
The present invention relates to compositions containing an mTOR inhibitor, such as rapamycin or a rapamycin derivative, in combination with a PI3 kinase inhibitor and/or a leptin inhibitor,...
US20090274685 ILT3 POLYPEPTIDES AND USES THEREOF  
This invention provides a method for inhibiting the rejection of transplanted islet cells, comprising administering to the subject a polypeptide comprising all or a portion of the extracellular...
US20090271182 COMPUTER-IMPLEMENTED METHODS AND SYSTEMS FOR MODELING AND RECOGNITION OF SPEECH  
In accordance with the present invention, computer implemented methods and systems are provided for representing and modeling the temporal structure of audio signals. In response to receiving a...
US20090269269 COPPER OXIDE NANOPARTICLE SYSTEM  
The disclosed subject matter provides a copper oxide nanoparticle, a catalyst that includes the copper oxide nanoparticle, and methods of manufacturing and using the same. The catalyst can be used...
7610384 Network telephony appliance and system for inter/intranet telephony  
A network appliance (100) is provided having a network controller subsystem (110) for coupling the appliance (100) to a data network for providing and receiving data packets to and from a packet...
7602320 Systems and methods for companding ADC-DSP-DAC combinations  
Systems and methods for resizing a signal for use with a fixed-point DSP are provided. More specifically, a process called companding is used in conjunction with fixed-point devices to resize a...
US20090254383 SYSTEM AND METHOD FOR ALLOCATING RESOURCES USING SPOT MARKET AND DERIVATIVE MARKET TECHNIQUES  
A method for controlling access to a system of finite resources with excess demand employs a two stage admission process. Subscribers are first admitted based on an initial bid price and resource...
7599965 Multimedia integration description scheme, method and system for MPEG-7  
The invention provides a system and method for integrating multimedia descriptions in a way that allows humans, software components or devices to easily identify, represent, manage, retrieve, and...
US20090234431 ARTERIOVENOUS GRAFT BLOOD FLOW CONTROLLERS AND METHODS  
Blood flow restrictors are discussed. In some examples, a restrictor apparatus includes a converging entry portion, a diverging exit portion, and optionally a narrowed portion therebetween to...
US20090234347 ELECTROTHERMAL INSTRUMENT FOR SEALING AND JOINING OR CUTTING TISSUE  
An instrument and method are provided for sealing and joining or hemostatically dividing tissue, which is particularly suitable for laparoscopic and endoscopic surgery. The instrument makes use of...
7588566 Electrothermal instrument for sealing and joining or cutting tissue  
An instrument and method are provided for sealing and joining or hemostatically dividing tissue, which is particularly suitable for laparoscopic and endoscopic surgery. The instrument makes use of...
7588550 Systems and methods of blood-based therapies having a microfluidic membraneless exchange device  
The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer...
US20090222477 METHODS, SYSTEMS, AND MEDIA FOR FORMING LINEAR COMBINATIONS OF DATA  
Methods, systems, and media for forming linear combinations of data are provided. In some embodiments, methods for forming a linear combination of data include: receiving at a device a first...
US20090221916 Systems and Methods for Elastography Imaging  
Methods for obtaining information about the mechanical behaviour of structures associated with mammalian joints and tendons are provided. Embodiments of such methods include creating deformation in...
7582740 Methods and kits for detecting SARS-associated coronavirus  
The present invention provides a synthetic nucleic acid sequence comprising 10-30 nucleotides of the N gene region and/or the 3′ non-coding region of the SARS-associated coronavirus genome, and a s...
US20090214533 METHODS FOR CONVERTING OR INDUCING PROTECTIVE IMMUNITY  
The invention is based in part on the finding that suppressing regulatory T cell function is needed in order to convert passive immunity into active antigen-specific immunity. Generally, the...
US20090214465 Quinoxaline Derivatives as Antitumor Agents  
The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also...
7579969 Systems and methods for creating and using a conditioning signal  
Systems and methods for creating and using a conditioning signal are provided. In some embodiments, systems for creating a conditioning signal providing information regarding an input signal are...
7579330 Methods of treating various cancers using melanoma differentiation associated protein-7  
This invention provides a method for reversing the cancerous phenotype of a cancer cell by introducing a nucleic acid having the melanoma differentiation associated gene (mda-7) into the cell under...
US20090208484 R-SPONDIN COMPOSITIONS AND METHODS OF USE THEREOF  
The invention provides for a method for screening compounds that bind to and modulate a regulator of Wnt signaling, R-spondin 4. The invention further provides for methods for diagnosing a...
US20090203002 MESENCHYMAL STEM CELLS AS A VEHICLE FOR ION CHANNEL TRANSFER IN SYNCYTIAL STRUCTURES  
The present invention provides a method of selectively amplifying fetal DNA sequences from a mixed, fetal-maternal source. This method utilizes differential methylation to allow for the selective...
US20090202544 Methods of Treating Diseases by Targeting Silt3  
This invention provides a method of treating a subject afflicted with a disease, comprising withdrawing blood from the subject, treating the withdrawn blood so as to remove sILT3 from the blood,...
US20090202429 METHODS FOR TESTING ANTI-THROMBOTIC AGENTS  
The invention provides a transgenic non-human animal expressing von Willebrand Factor A1 protein containing at least one mutation selected from the group consisting of: 1263P>S, 1269N>D, 1274K>R,...
7573956 Time encoding and decoding of a signal  
Analog signals can be fully encoded as an asynchronous time sequence generated by a time encoding machine (TEM). With knowledge of the parameters of the time encoding machine, the asynchronous time...
US20090191657 ALL-SILICON RAMAN AMPLIFIERS AND LASERS BASED ON MICRO RING RESONATORS  
Methods of manufacturing a lasing device are provided by some embodiments, the methods including: creating a silicon micro ring with a predetermined radius and a predetermined first cross-sectional...
US20090191244 MICROBUBBLES AND METHODS FOR OXYGEN DELIVERY  
Compositions containing a carrier and microbubles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles...
7563461 Zinc salt compositions for the prevention of dermal and mucosal irritation  
The present invention relates to methods and compositions which employ low concentrations of combinations of zinc salts to prevent the irritation of skin or mucous membranes that may be caused by...
US20090180950 Polychromatic, diversely-sized particles for angiography  
The invention involves polychromatic particles of various sizes for assessing blood flow, blood barrier leakage and blood vessel leakage.
US20090175845 METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE PHB DOMAIN PROTEIN ACTIVITY AND COMPOSITIONS THEREOF  
The invention relates to the finding that PHB domain polypeptides can bind cholesterol and related compounds and are involved in the regulation of various cellular activities. Accordingly, the...
US20090175805 Neuraminidase Inhibitors and uses thereof  
The invention is related to various methods for inhibiting or reducing biofilm formation, treating a biofilm production-related disorder, preventing biofilm formation, and screening for...
7555840 Omni-directional lens in sundials and solar compasses  
Sundials and solar compasses including are disclosed. Some embodiments include an omni-directional lens, which can focus a sun beam into a sharp spot with a long depth of field. By projecting the...
7554596 Method and apparatus for recording a sequence of images using a moving optical element  
An imager (200) including a spatially varying optical element (204) which moves while the imager records a sequence of images. The optical element (204) can be an intensity reduction filter, a...
US20090157736 MULTIMEDIA INTEGRATION DESCRIPTION SCHEME, METHOD AND SYSTEM FOR MPEG-7  
The invention provides a system and method for integrating multimedia descriptions in a way that allows humans, software components or devices to easily identify, represent, manage, retrieve, and...
US20090157573 System And Method For Grading Electricity Distribution Network Feeders Susceptible To Impending Failure  
A machine learning system creates failure-susceptibility rankings for feeder cables in a utility's electrical distribution system. The machine learning system employs martingale boosting algorithms...
US20090156668 Ginkgolide Compounds, Compositions, And Extracts, And Uses Thereof  
The present invention relates to Ginkgolide derivatives, compositions and extracts comprising one or more Ginkgolides and/or derivatives thereof and methods of use of the compositions to treat...
US20090154823 Systems and Method for De-Blurring Motion Blurred Images  
Systems and methods for providing a substantially de-blurred image of a scene from a motion blurred image of the scene are disclosed. An exemplary system includes a primary detector for sensing the...
7548094 Systems and methods for on-chip signaling  
Systems and methods for on-chip signaling are disclosed. In some embodiments, an integrated circuit having on-chip signaling between a first component and a second component includes, a...