Patents and Patent Applications from Columbia University


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US20060292157 MDA-7 protein variants having antiproliferative activity  
The invention relates to the mda-7 gene, its encoded protein and fragments of the protein. Several of these fragments of the MDA-7 protein exhibit antiproliferative activity and/or inhibited the...
7151801 Method and system for enhancing data quality  
The quality (e.g., resolution) of image data, video data, and sound data representing a scene or signal is enhanced by a quality enhancement function trained on high quality and low quality...
7149770 Method and system for client-server interaction in interactive communications using server routes  
In an interactive communication system based on MPEG-4, Command descriptors along with Command Route nodes or Server Routes in the scene description can be used to support application-specific...
7149262 Method and apparatus for enhancing data resolution  
A resolution enhancement algorithm is trained on sample images to obtain a polynomial model mapping of low resolution image data to high resolution image data. The polynomial model mapping is...
US20060275744 Modified human embryonic stem cells and methods of use to treat neuron-associated disorders  
The invention is directed to methods for promoting the differentiation and maturation of embryonic and adult stem cells to dopamine neurons by increasing expression of the transcription factors...
7145408 Resonant clock distribution for very large scale integrated circuits  
A circuit for distributing a clock signal in an integrated circuit includes a capacitive clock distribution circuit. At least one additional inductor is formed in a metal layer of the integrated...
7145021 Analogs of terpene trilactones from Ginkgo biloba and related compounds and uses thereof  
The subject invention provides compounds having the structure: wherein R1 is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R2 is H, OH, a photoactivatable moiety,...
7144728 Method of inducing anergic T helper cells  
This invention also provides a method of generating antigen specific human suppressor CD8+CD28− T cells. This invention further provides a method of generating allopeptide antigen specific human s...
7141227 Apparatus and method for preparing cerium oxide nanoparticles  
This invention provides a method for preparing cerium oxide nanoparticles with a narrow size distribution. The cerium oxide nanoparticles obtained by the method of the invention are nearly all...
US20060265300 Financial contracts and market indicators based on such financial contracts  
Products and methods for providing investors with one or more financial contracts, based on average drawdown, average drawup, and/or average range are provided. Some embodiments of the present...
7140039 Identification of an attacker in an electronic system  
A method for identifying a particular component of an electronic system that accesses a resource of the electronic system using electronic security value units is described. First, electronic...
7139420 Method for tomographic reconstruction with non-linear diagonal estimators  
Techniques for tomographic reconstruction using non-linear diagonal estimators are disclosed. In a preferred embodiment, tomographic data from a tomographic device is decomposed in a wavelet vector...
US20060254500 Line scan sequential lateral solidification of thin films  
A polycrystalline film is prepared by (a) providing a substrate having a thin film disposed thereon, said film capable of laser-induced melting, (b) generating a sequence of laser pulses having a...
US20060254200 Systems and methods for construction of space-truss structures  
Systems and methods for construction of space-truss structures are described herein. In some embodiments, software is provided that includes a design module for providing a three-dimensional...
US20060252786 Nicotinic-opioid synergy for analgesia  
This invention provides two methods for reducing, or inhibiting the onset of, pain in a subject. The first method for reducing, or inhibiting the onset of, pain in a subject comprises administering...
7132972 Continuous-time digital signal generation, transmission, storage and processing  
A method of digitally processing an analog signal in continuous time includes producing a continuous-time digital signal from an analog signal via a technique that does not include periodic...
7132096 Antimicrobial activity of gemfibrozil  
The present invention provides methods for inhibiting growth of a bacterium which consists essentially of contacting the bacterium with gemfibrozil, or a related compound, in a concentration...
7126001 Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof  
The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino,...
7125976 Method of screening for agents inhibiting chloride intracellular channels  
The present invention isolates and characterizes the exc-4 gene of C. elegans, and identifies exc-4 as an orthologue of the human CLIC family of chloride intracellular channels. Accordingly, a...
7125956 Compounds which prevent neuronal cell death and uses thereof  
The present invention provides for a compound having the structure: (AA1)n-Cys-(AA2)m wherein n=0,1,2,3,4 or 5 and m=0,1,2,3,4 or 5, provided the sum of (n+m) is greater than or equal to two and...
7125675 Method for inhibiting tumor invasion or spreading in a subject  
The present invention provides for a method for inhibiting tumor invasion or metastasis in a subject which comprises administering to the subject a therapeutically effective amount of a form of...
7125658 Small protein that interacts with a ribonucleotide reductase subunit and uses thereof  
The present invention provides for an isolated Sml1 protein or a homologue thereof. The present invention also provides for a screening assay for identifying compounds that are capable of reducing...
7122307 High throughput biological heart rate monitor that is molecularly determined  
This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells. Cardiac myocytes disaggregated from neonatal...
7115503 Method and apparatus for processing thin metal layers  
A method and apparatus for processing a thin metal layer on a substrate to control the grain size, grain shape, and grain boundary location and orientation in the metal layer by irradiating the...
US20060211683 Erastin and erastin binding proteins, and uses thereof  
The invention relates to methods of screening for binding partners, especially binding partners essential for the biological activity of erastin (e.g. VDACs such as VDAC3). The invention also...
7110977 System and method for allocating resources using spot market and derivative market techniques  
A method for controlling access to a system of finite resources with excess demand employs a two stage admission process. Subscribers are first admitted based on an initial bid price and resource...
7106327 Systems and methods for modeling the impact of a medium on the appearances of encompassed light sources  
The present invention provides systems and methods for modeling the impact of a medium on the appearances of encompassed light sources using a Legendre polynomial series solution to a Radiative...
7105149 Isolation of five novel genes coding for new Fc receptors-type melanoma involved in the pathogenesis of lymphoma/myeloma  
This invention provides an isolated nucleic acid molecule which encodes immunoglobulin receptor, Immunoglobulin superfamily Receptor Translocation Associated, IRTA, protein. Provided too, are the...
7103930 Device for the calibration and standardization of hip rotation  
The present invention concerns a device for the calibration and standardization of the rotation and movement of a patient's hip. More particularly the present invention relates to a device for the...
7103522 Methods for estimating the body voltage of digital partially depleted silicon-on-insulator circuits  
Techniques for estimating a body voltage of one or more transistors which form digital partially depleted silicon-on-insulator circuit, and for using estimated voltages to analyze electrical...
7101838 Method to prevent accelerated atherosclerosis using (sRAGE) soluble receptor for advanced glycation endproducts  
The present invention provides for a method to prevent accelerated atherosclerosis in a subject predisposed thereto which comprises administering to the subject a polypeptide derived from soluble...
US20060194767 Novel agents for preventing and treating disorders involving modulation of the RyR receptors  
The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds...
7094805 Total synthesis of merrilactone A  
This invention provides a total synthesis of Merrillactone and Merrilactone analogues for use as neurotrophic agents in the treatment of neurodegenerative diseases. The invention also provides...
7094401 HCV core protein binding agents for treatment of hepatitis C virus infection  
The present invention provides a method of treating or preventing hepatitis C virus infection in a subject which comprises administering an effective amount of an agent to the subject, wherein the...
US20060184614 Thin-client network computing method and system  
A method and system are provided for executing an application remotely on a server computer for a client computer in a computer network. The server receives at user input from the client computer...
7084905 Method and apparatus for obtaining high dynamic range images  
Disclosed are method and apparatus for obtaining relatively high dynamic range images using a relatively low dynamic range image sensor without significant loss of resolution. The image sensor has...
7083918 Bacterial small-molecule three-hybrid system  
A transgenic bacterial cell comprising (a) a dimeric small molecule which comprises a first moiety known to bind a first receptor domain covalently linked to a second moiety known to bind a second...
7083613 Ringed forceps  
A surgical instrument comprises two oppositely-positioned working numbers each having proximal and distal ends and each having a working surface. The instrument also comprises at least one ring...
7081446 Long-acting follicle stimulating hormone analogues and uses thereof  
This invention provides FSH analogues having increased serum half-life relative to FSH. This invention also provides related compositions and methods for increasing fertility, egg production and...
7081241 Extracellular rage binding protein (EN-RAGE) and uses thereof  
The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of...
7074771 Gene encoding MNR2 and uses thereof  
This invention provides an isolated nucleic acid molecule encoding a motor neuron restricted pattern, MNR2, protein. This invention provides an isolated nucleic acid molecule of at least 15...
7074769 Oligonucleotide inhibitors of bcl-xL  
This invention provides an antisense oligonucleotide or analog thereof comprising 10 or more contiguous bases or base analogs from the sequence of bases of sequence A, B, C, D, E, F, G, H, I, J, K,...
7074621 Surface plasmon resonance biosensor for measurement of anti-glycolipid antibody levels in neuropathy  
The present invention provides a method of detecting human antibodies in a sera solution. The invention also provides a method of quantitating anti-glycolipid antibody levels in solutions. The...
7074597 Multiplex genotyping using solid phase capturable dideoxynucleotides and mass spectrometry  
This invention provides methods for detecting single nucleotide polymorphisms and multiplex genotyping using dideoxynucleotides and mass spectrometry.
7070777 Method for inhibiting inflammation with an antibody that binds the 5C8 protein  
This invention provides for methods of inhibiting inflammation with antibodies that bind the 5c8 protein.
7067326 Synthetic receptors, libraries and uses thereof  
Libraries of synthetic receptors are disclosed. The receptors include a polyfunctional organic template which is covalently linked to two or more oligomers. The oligomers may be the same or...
7066879 Insertable device and system for minimal access procedure  
The present invention provides a system and single or multi-functional element device that can be inserted and temporarily placed or implanted into a structure having a lumen or hollow space, such...
US20060133666 Methods and systems for feature selection  
Methods and systems for feature selection are described. In particular, methods and systems for feature selection for data classification, retrieval, and segmentation are described. Certain...
7060870 Transgenic mice over-expressing ABAD and mutant APP in brain as model of Alzheimer's disease and uses thereof  
The present invention provides for a transgenic non-human animal whose cells contain a DNA sequence comprising: (a) a nerve tissue specific promoter operatively linked to a DNA sequence which...
7060802 Tumor-associated marker  
This invention provides monoclonal antibody-producing hybridomas designated 27.F7 and 27.B1. The invention also provides methods for detecting TIP-2 antigen-bearing cancer cells in a sample,...