Patents and Patent Applications from Case Western Reserve University


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8183342 Method of treating chemotherapy-induced thrombocytopenia  
A method of treating chemotherapy-induced thrombocytopenia includes administering to a subject undergoing chemotherapy a therapeutically effective amount of a Bax-inhibiting peptide.
US20120100615 CELL FATE CONVERSION OF DIFFERENTIATED SOMATIC CELLS INTO GLIAL CELLS  
The present invention relates to the reprogramming of differentiated somatic cells, such as those differentiated cells that arise from embryonic mesoderm, into glial cells. Glial cells produced...
US20120100113 DIFFERENTIATION METHOD FOR PRODUCTION OF GLIAL CELL POPULATIONS  
The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in relatively...
US20120098152 POROUS MATERIAL HAVING ANISOTROPIC STRUCTURE AND METHOD OF MAKING THE SAME  
A method of forming an anisotropic porous material includes forming an aerogel precursor, the aerogel precursor including a matrix material and a liquid dispersion medium for dispersing the matrix...
8165685 System and method for therapeutic neuromuscular electrical stimulation  
A system for neuromuscular electrical stimulation therapy includes one or more sensors for sensing the position or the muscle contractions of a body part, such as an arm, hand, finger, leg, etc.; a...
US20120095084 MODULATION OF SEROTONIN NEURONS INVOLVING THE PET-1 TRANSCRIPTIONAL CONTROL REGION  
Serotonin neurons modulate most homeostatic Central Nervous System (CNS) functions while influencing the expression of behavioral traits such as mood, aggression and anxiety. Serotonin neuron...
8158373 Method of detecting cancer and evaluating cancer prognosis  
A method of detecting cancer in a subject is provided. One step of the method includes obtaining a bodily sample from the subject. Next, the level of pro-prion protein (pro-PrP) in the bodily...
US20120088857 POLYMER REINFORCED POROUS MATERIAL AND METHOD OF MAKING SAME  
A method of forming a porous material having improved compressive strength, includes forming an aerogel precursor that includes a polymer having a functional group capable of undergoing a...
US20120088855 LOW DENSITY HYDROPHOBIC MATERIAL AND METHOD OF MAKING THE SAME  
Low density, buoyant materials, in particular hydrophobic aerogels, may be used to absorb hydrophobic liquids. The materials are adapted to float on aqueous solutions and can absorb oils or other...
US20120086139 POROUS MATERIAL HAVING CONTROLLED VOIDS AND METHOD OF MAKING THE SAME  
A porous material having controlled void dimensions and method of forming the same includes forming an aerogel precursor, the aerogel precursor including a matrix material and a liquid dispersion...
8154092 Silicon carbide MEMS structures and methods of forming the same  
MEMS structures that include silicon carbide micromechanical components, as well as methods of forming and using the same, are provided. The silicon carbide micromechanical components may be...
8153280 Composition comprising silicon carbide  
A method of depositing a ceramic film, particularly a silicon carbide film, on a substrate is disclosed in which the residual stress, residual stress gradient, and resistivity are controlled. Also...
US20120083543 POROUS MATERIAL HAVING IMPROVED COMPRESSIVE STRENGTH AND METHOD OF MAKING SAME  
A method of forming a porous material having improved compressive strength includes forming an aerogel precursor, the aerogel precursor including a matrix material and a liquid dispersion medium...
US20120075638 SEGMENTATION AND QUANTIFICATION FOR INTRAVASCULAR OPTICAL COHERENCE TOMOGRAPHY IMAGES  
A system and related methods for automatic or semi-automatic segmentation and quantification of blood vessel structure and physiology, including segmentation and quantification of lumen, guide...
8144744 Co-extruded multilayer polymers films for all-polymer lasers  
A polymer film laser is provided that comprises a plurality of extruded polymer layers. The plurality of extruded polymer layers comprises a plurality of alternating dielectric layers of a first...
US20120071810 PHOTODYNAMIC THERAPY INCLUDING LIGHT PRETREATMENT  
A method of photodynamic therapy is described that includes administering a therapeutically effective amount of a photosensitizer to an area of tissue such as the skin of a subject, delivering a...
8137991 Methods of reducing angiogenesis of age-related macular degeneration (AMD) or choroidal neovascularization by an anti-carboxyetheylpyrrole (CFP) antibody  
The present invention pertains to methods of inhibiting angiogenesis in an individual in need thereof comprising administering to the individual an agent that inhibits one or more CEP protein...
US20120063655 METHODS AND SYSTEMS FOR PRODUCING AN IMPLANT  
A computer implemented method for determining the 3-dimensional shape of an implant to be implanted into a subject includes obtaining a computer readable image including a defective portion and a...
US20120053448 INTERVENTION-INDEPENDENT SCAN PLANE CONTROL FOR MRI  
Example systems, apparatus, circuits, and so on described herein concern intervention-independent scan plane control for an MRI system. A tracking device capable of being manipulated independently...
8124749 Targeted cell death  
The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or...
8124097 Hybrid and chimeric polypeptides that regulate activation of complement  
A hybrid complement-regulating protein comprises a first functional unit of a first complement regulatory protein having complement regulating properties, a first spacer sequence of at least about...
US20120039519 SYSTEMS AND METHODS FOR GENERATING IMAGES FOR IDENTIFYING DISEASES  
A method is provided that comprises receiving a first digital radiography (DR) image of at least a portion of a body of a patient, receiving a second DR image of the at least a portion of a body of...
8114847 Selective inhibitors of translesion DNA replication  
An agent for inhibiting translesion DNA replication comprises a non-natural adenine ribose analog represented by those as set forth in FIG. 1.
US20120001630 DARK BLOOD BALANCED STEADY STATE FREE PRECESSION IMAGING  
Systems, methods, and other embodiments associated with controlling a magnetic resonance imaging (MRI) apparatus to perform a balanced steady state free precession (bSSFP) technique that includes...
US20110311158 MOTION ARTIFACT REMOVAL  
Systems, methods, and other embodiments associated with removing motion artifacts from MR images are described. One example method includes controlling an MRI apparatus to acquire a fully sampled,...
US20110305638 Modulation of Macrophage Activation  
The invention provides methods for treating pathological conditions associated with an undesirable inflammatory component. The invention is generally directed to reducing inflammation by...
8078264 Intra-operative molecular imaging  
A system for imaging an abnormal cell and or diseased tissue after topical application of a near infrared protease-specific probe is disclosed. The system includes a protease-specific near infrared...
8076088 Method of detecting human β-defensins  
A method of detecting β-defensin in a bodily sample from a subject includes reducing the electrostatic interaction between β-defensin and negatively charged moieties in the bodily sample prior to d...
8073230 Systems and methods for generating images for identifying diseases  
Systems and methods for generating images for identifying diseases are provided. In one embodiment, a method comprises receiving a first digital radiography (DR) image of at least a portion of a...
US20110293578 Use of Stem Cells to Prevent Neuronal Dieback  
The invention is generally directed to treatment of neuronal injury. In particular, the invention is directed to reducing axonal retraction (“dieback”) that occurs as a result of the int...
US20110279118 CONTROLLING MULTI-CHANNEL TRANSMITTER EFFECTS ON SPECIFIC ABSORPTION RATE  
Systems, methods, and other embodiments associated with controlling the specific absorption rate (SAR) in a patient associated with a conductor are described. The conductor may be, for example, a...
8060208 Action potential conduction prevention  
An example method for selectively and reversibly preventing the conduction of action potentials in a targeted nerve region is presented. The method includes generating an electrical waveform having...
8059907 Constant variance filter  
Systems and methods associated with a constant variance filter are described. One system embodiment includes a memory to store a spatially dependent filtered data set having a first degree of...
RE42887 Silicon carbide and other films and method of deposition  
A method of depositing a ceramic film, particularly a silicon carbide film, on a substrate is disclosed in which the residual stress, residual stress gradient, and resistivity are controlled. Also...
8050669 Beacon group merging  
A method of merging two or more beacon groups (BGs), each BG comprising one or more wireless devices, the method comprising, determining a leader BG based on merging information broadcast by two or...
8049500 Dynamically selectively configuring wireless transmitter associated with MRI detector coil  
Systems, methods, and other embodiments associated with dynamically selectively configuring wireless transmitters associated with MRI detector coils are described. One example apparatus includes a...
8049499 Controlling multi-channel transmitter effects on specific absorption rate  
Systems, methods, and other embodiments associated with controlling the specific absorption rate (SAR) in a patient associated with a conductor are described. The conductor may be, for example, a...
US20110264178 Probe for Neural Stimulation  
A neural probe for stimulating neural tissue is disclosed. The probe comprises a three-dimensional arrangement of individually addressable electrodes. As a result, embodiments of the present...
8046047 Extended-coverage imaging coil  
Extended-coverage magnetic resonance imaging coils with optimized homogeneity in longitudinal sensitivity are described. One exemplary coil includes four elements, where two of the elements are...
8034779 Inhibitors of BCL-2  
A purified polypeptide includes an amino acid sequence consisting of about 10 to 80 amino acids, the amino acid sequence having a sequence identity at least 90% homologous to a portion of SEQ ID...
US20110241685 SWITCHED MODE PRE-AMPLIFICATION AND AM FEEDBACK FOR ON-COIL SWITCHED MODE AMPLIFIERS IN PARALLEL TRANSMISSION MRI  
Example systems, apparatus, circuits, and so on described herein concern parallel transmission in MRI with on-coil current-mode (CMCD) amplifiers. One example apparatus includes switched...
US20110241682 ON-COIL CURRENT MODE CLASS D RF POWER AMPLIFIER IN HIGH FIELD PARALLEL TRANSMISSION MRI  
Example systems, apparatus, circuits, and so on described herein concern parallel transmission in high field MRI. One example apparatus includes a balun network that produces out-of-phase signals...
US20110241681 HALL EFFECT CURRENT SENSOR  
Example systems, apparatus, circuits, and so on described herein concern a Hall effect current sensor that includes a planar portion of a conductor that is oriented perpendicular to a base magnetic...
8030921 Methods for fat signal suppression in magnetic resonance imaging  
This application is directed to methods for chemical species signal suppression in magnetic resonance imaging procedures, where Dixon techniques are enhanced by continuously sampling techniques....
8030919 Dark blood balanced steady state free precession imaging  
Systems, methods, and other embodiments associated with controlling a magnetic resonance imaging (MRI) apparatus to perform a balanced steady state free precession (bSSFP) technique that includes...
8029942 Fuel cell system with flow field capable of removing liquid water from the high-pressure channels  
A fuel cell system having flow fields capable to operate like interdigitated flow fields, but in the same time allowing the removal of liquid water collected in the high-pressure channels,...
8026488 Methods for positive emission tomography (PET) target image segmentation  
A method for positive emission tomography (PET) target image segmentation is provided. The method comprises capturing and digitizing image data of a selected target, determining an initial...
US20110217708 METHODS AND COMPOSITIONS FOR DETECTING COLON CANCERS  
This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in...
RE42641 Depth-resolved spectroscopic optical coherence tomography  
A method is described for determining depth-resolved backscatter characteristics of scatterers within a sample, comprising the steps of: acquiring a plurality of sets of cross-correlation...
8005472 Method of reporting poor RF coverage in a wireless network  
The present invention provides a method for storing data relating to network conditions in a mobile unit. A mobile station receives a signal from a base station. The mobile station stores data...