Patents and Patent Applications from Case Western Reserve University


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10078895 Prediction of recurrence of non-small cell lung cancer with tumor infiltrating lymphocyte (TIL) graphs  
Methods and apparatus predict non-small cell lung cancer (NSCLC) recurrence using radiomic features extracted from digitized hematoxylin and eosin (H&E) stained slides of a region of tissue...
10077509 Production of micro- and nano-fibers by continuous microlayer coextrusion  
A multilayered polymer composite film includes a first polymer material forming a polymer matrix and a second polymer material coextruded with the first polymer material. The second polymer...
10076264 System and method for quantitative magnetic resonance (MR) analysis using T1 mapping  
Example apparatus and methods concern determining whether a target material appears in a region experiencing nuclear magnetic resonance (NMR). One method acquires a baseline value for a magnetic...
US20180259473 SENSOR APPARATUS, SYSTEMS AND METHODS OF MAKING SAME  
A sensor system can be configured to perform dielectric spectroscopy (DS). For example, the system can include a sensor configured to measure dielectric permittivity of a fluid in response to an...
US20180256886 HIGH-CHARGE CAPACITY ELECTRODES TO DELIVER DIRECT CURRENT NERVE CONDUCTION BLOCK  
The present disclose generally relates to high-charge capacity electrodes that include a substrate and a coating covering at least a portion of the substrate that includes active particles held...
US20180256758 COATED PLANT VIRUS IMAGING AGENTS  
An imaging nanoparticle comprising a plant virus particle having an interior surface and an exterior surface, an imaging agent that is linked to the interior and/or exterior surface, and a layer...
US20180256646 COMPOSITIONS AND METHODS FOR MODULATING TOLL LIKE RECEPTOR SIGNAL  
A method of method of inhibiting Toll like receptor (TLR) signaling in dendritic cells (DCs) of a subject in need thereof includes administering at least one complement antagonist to the DCs at an...
US20180256614 COMPOSITIONS AND METHODS OF TREATING OF BACTERIAL INFECTIONS WITH BETA-LACTAMASE INHIBITORS  
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one...
10071241 Therapy delivery devices and methods for non-damaging neural tissue conduction block  
Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue....
US20180253841 PREDICTING CANCER RECURRENCE USING LOCAL CO-OCCURRENCE OF CELL MORPHOLOGY (LOCOM)  
Embodiments include apparatus for predicting cancer recurrence based on local co-occurrence of cell morphology (LoCoM). The apparatus includes image acquisition circuitry that identifies and...
US20180253591 PREDICTING CANCER PROGRESSION USING CELL RUN LENGTH FEATURES  
Embodiments include an image acquisition circuit configured to access an image of a region of tissue demonstrating cancerous pathology, a nuclei detection and graphing circuit configured to detect...
US20180252665 SYSTEM AND METHODS FOR THE DETECTION OF BIOMARKERS OF NEURODEGENERATIVE DISORDERS  
A sensor for the detection of β-amyloid 42, T-Tau, and/or P-Tau in a sample includes a substrate, a working electrode and counter electrode formed on a surface of the substrate, and an...
US20180250506 ADJUSTABLE NERVE ELECTRODE  
Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve...
10068706 Multilayer polymer dielectric film  
A multilayer polymer dielectric film includes a stack of coextruded, alternating first dielectric layers and second dielectric layers that receive electrical charge. The first dielectric layers...
10066020 Methods of detecting cancer  
A method of detecting the presence of glioblastomas and/or recurrent glioblastomas in a subject in need thereof includes isolating CD14+ cells from a blood sample of the subject and determining...
10064594 Characterizing disease and treatment response with quantitative vessel tortuosity radiomics  
Methods, apparatus, and other embodiments associated with classifying a region of tissue using quantified vessel tortuosity are described. One example apparatus includes an image acquisition logic...
US20180247410 PREDICTING IMMUNOTHERAPY RESPONSE IN NON-SMALL CELL LUNG CANCER WITH SERIAL RADIOMICS  
One embodiment include an image acquisition circuit that accesses a pre-treatment and a post-treatment image of a region of tissue demonstrating non-small cell lung cancer (NSCLC), a segmentation...
US20180247010 INTEGRATED METHOD AND SYSTEM FOR IDENTIFYING FUNCTIONAL PATIENT-SPECIFIC SOMATIC ABERATIONS USING MULTI-OMIC CANCER PROFILES  
A system and method for determining the functional impact of somatic mutations and genomic aberrations on downstream cellular processes by integrating multi-omics measurements in cancer samples...
US20180243555 SYSTEMS AND METHODS FOR TRANSCUTANEOUS DIRECT CURRENT BLOCK TO ALTER NERVE CONDUCTION  
One aspect of the present disclosure relates a system that can alter (e.g., block or attenuate) conduction in a nerve by transcutaneous DC application (tDCB). The system can include a current...
US20180243232 POLYMER FIBER SCAFFOLDS AND USES THEREOF  
A multilayered polymer composite film includes a water-soluble polymer matrix and a plurality of fibers embedded within the water soluble polymer matrix. The fibers include a water insoluble...
US20180242906 PREDICTING IMMUNOTHERAPY RESPONSE IN NON-SMALL CELL LUNG CANCER WITH SERIAL QUANTITATIVE VESSEL TORTUOSITY  
One embodiment includes an image acquisition circuit that accesses a pre-treatment and a post-treatment image of a region of tissue demonstrating non-small cell lung cancer (NSCLC), a segmentation...
US20180242905 PREDICTING IMMUNOTHERAPY RESPONSE IN NON-SMALL CELL LUNG CANCER PATIENTS WITH QUANTITATIVE VESSEL TORTUOSITY  
Embodiments classify a region of tissue demonstrating non-small cell lung cancer using quantified vessel tortuosity (QVT). One example apparatus includes annotation circuitry configured to segment...
10059978 Methods and devices for diagnosis of particles in biological fluids  
Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as...
10058736 Bike system for use in rehabilitation of a patient  
A system for use in rehabilitation of a target patient is provided. The system includes at least two bicycle devices for use by the target patient and a second operator other than the target...
10058588 Inhibitors of BCL-2  
A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids of SEQ ID NO:1.
10055842 Entropy-based radiogenomic descriptions on magnetic resonance imaging (MRI) for molecular characterization of breast cancer  
Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One...
US20180233849 ASYMMETRICAL-FORCE CONNECTOR SYSTEM  
An asymmetrical-force connector system includes a socket having a longitudinally-oriented shaft bore defining a bore axis. A spring-receiving cavity is coaxial with the bore axis and extends...
US20180233763 COPPER BASED FLOW BATTERIES  
A copper based redox flow cell. In one aspect, the present technology provides a copper based flow battery comprising a first half-cell comprising a first electrolyte providing a source of ions...
US20180231626 SYSTEMS AND METHODS FOR MAGNETIC RESONANCE FINGERPRINTING FOR QUANTITATIVE BREAST IMAGING  
Systems and methods for acquiring three-dimensional imaging data from a breast of a subject includes acquiring, with a nuclear magnetic resonance (NMR) system, NMR data from a volume of interest...
US20180228905 COMPOSITIONS AND METHODS FOR INHIBITING THE ACTIVITY OF LAR FAMILY PHOSPHATASES  
A method of inhibiting and/or reducing the activity, signaling, and/or function of leukocyte-common antigen related (LAR) family of phosphatases in a cell of a subject induced by proteoglycans...
US20180228844 METHOD OF GENERATING TUMOR-SPECIFIC T CELLS  
A method of treating cancer in a subject includes contacting an enriched population of T-cells obtained from cancer or tumor draining lymph nodes ex-vivo with: an anti-CD3 antibody, an anti-CD28...
US20180228843 COMPOSITIONS AND METHODS OF TREATING A T CELL MEDIATED DISORDER  
A method of generating a CD4+FoxP3+ Treg cell, the method includes administering at least one complement antagonist to a naive CD4+T cell at an amount effective to substantially inhibits C3a...
US20180228743 COMPOUNDS AND METHODS OF PROMOTING MYELINATION  
A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount...
10049770 Prediction of recurrence of non-small cell lung cancer  
Methods, apparatus, and other embodiments associated with predicting non-small cell lung cancer (NSCLC) patient response to adjuvant chemotherapy therapy using radiomic features extracted from...
10049450 High-throughput adaptive sampling for whole-slide histopathology image analysis  
Methods, apparatus, and other embodiments associated with classifying a region of tissue represented in a digitized whole slide image (WSI) using iterative gradient-based quasi-Monte Carlo (QMC)...
10045953 Ceramide composition and method of use  
A method for treating and preventing diseases associated with neutrophil infiltration, particularly ocular diseases, is provided, which method comprises administering to a subject in need thereof...
10045937 Therapeutic agent delivery system and method  
A therapeutic agent delivery system includes a therapeutic agent delivery platform and a therapeutic guest agent. The therapeutic agent delivery platform is capable of being implanted in a tissue...
10040147 Low-melting iron-based filler alloys  
A braze alloy includes by atom %, about 30% to about 60% iron, 0 to about 40% nickel, and about 10% to about 20% in total of melting point depressants selected from the group consisting of...
10039917 Adjustable nerve electrode  
Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve...
US20180217220 Systems and Methods for Free-Breathing Three-Dimensional Magnetic Resonance Fingerprinting  
A system and method for generating quantitative images of a subject using a nuclear magnetic resonance system. The method includes performing a navigator module to acquire navigator data, and...
US20180214111 DECISION SUPPORT FOR DISEASE CHARACTERIZATION AND TREATMENT RESPONSE WITH DISEASE AND PERI-DISEASE RADIOMICS  
Methods, apparatus, and other embodiments associated with classifying a region of tissue using textural analysis are described. One example apparatus includes an image acquisition logic that...
US20180211383 PHASE-DECORRELATION OPTICAL COHERENCE TOMOGRAPHY-BASED PARAMETER MEASUREMENT  
One example includes a scanning system. The system includes a phase-decorrelation optical coherence tomography (PhD-OCT) scanner configured to implement a scanning sequence via an optical signal...
10030228 Scaffold-free tissue constructs  
A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and...
US20180203082 System and Method for Low Rank Approximation of High Resolution MRF Through Dictionary Fitting  
A system and method is provided for generating a map of a tissue property in a subject using magnetic resonance fingerprinting (MRF) and a compressed MRF dictionary, where the compressed MRF...
US20180200507 METHOD TO TREAT PAIN THROUGH ELECTRICAL STIMULATION OF NERVES  
Methods of treating pain are disclosed, wherein a non-pulsed, low-frequency electrical current is applied to the nerve carrying the pain signals in order to suppress transmission of those signals....
10026015 Imaging control to facilitate tracking objects and/or perform real-time intervention  
A method includes acquiring image data from for a given time step. The image data represents at least one of an instrument and a target within an image space that includes patient anatomy. A given...
10024798 Multifocal hyperspectral raman system and methods for imaging of materials  
A hyperspectral Raman imaging system having the ability to focus on excitation laser beam over a relatively wide field of view due to the use of a lens array, in particular a microlens array....
10017868 Electrochemical processing of materials, methods and production  
Electrochemically aligned and compacted molecules, nanoparticles and microparticles with ampholytic nature, such as collagen, elastin, keratin and charged nanoparticle materials, methods of making...
US20180185403 METHODS OF DIAGNOSING AND TREATING CANCER  
A method of treating cancer in a subject includes determining the p53 status and the level of UDG in cancer cells of the subject and administering an antimetabolite agent in combination with an AP...
US20180185382 COMPOSITIONS AND METHODS FOR TREATING CANCER  
A method of treating cancer in a subject in need thereof includes administering to the subject therapeutically effective amounts of a PP2A activator and a protein kinase inhibitor.