Patents and Patent Applications from Case Western Reserve University


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US20190347789 DISTINGUISHING HYPERPROGRESSION FROM OTHER RESPONSE PATTERNS TO PD1/PD-L1 INHIBITORS IN NON-SMALL CELL LUNG CANCER WITH PRE-THERAPY RADIOMIC FEATURES  
Embodiments access a pre-immunotherapy image of tissue demonstrating NSCLC including a tumor and a peritumoral region; extract a first set of radiomic features from the image; provide the first...
US20190347670 SYSTEMS AND METHODS FOR DATA ANALYTICS FOR VIRTUAL ENERGY AUDITS AND VALUE CAPTURE ASSESSMENT OF BUILDINGS  
A system may provide virtual energy audits of one or more target buildings. The system may retrieve weather data and energy usage data specific to a given target building from a weather server and...
10472406 Insulin analogues with selective signaling properties and reduced mitogenicity  
A two-chain insulin analog contains Aspartic Acid at position B10 and penta-fluoro-Phenylalanine at position B24, optionally Histidine or Glutamic Acid at position A8, optionally additional...
10471118 Retinylamine derivitives for treatment of ocular disorders  
A pharmaceutical composition includes a retinylamine derivative having the following formula (I): where R1 is an amino acid residue, a dipeptide or a tripeptide that is linked to the retinylamine...
10470734 Characterizing lung nodule risk with quantitative nodule and perinodular radiomics  
Embodiments associated with classifying a region of tissue using features extracted from nodules and surrounding structures. One example apparatus includes a feature extraction circuit configured...
10470680 System and method for mapping activity in peripheral nerves  
Systems and methods are provided for controlling an entity in response to activity in a peripheral nerve comprising a plurality of fascicles. A multicontact electrode assembly is configured to...
US20190340463 SYSTEM AND METHOD FOR MAGNETIC RESONANCE FINGERPRINTING USING A PLURALITY OF PULSE SEQUENCE TYPES  
A method for performing magnetic resonance fingerprinting includes acquiring a plurality of MR image datasets using at least two pulse sequence types, the plurality of MR image datasets...
US20190339274 METHOD FOR DETECTING HIV-1 CO-RECEPTOR TROPISM  
A method for determining HIV-1 co-receptor tropism in an HIV-infected patient includes preparing an HIV-1 envelope protein coding sequence from a sample, introducing the HIV-1 envelope protein...
US20190337214 MIXING ELEMENT FOR EXTRUSION OPERATIONS  
A mixing element for an extruder screw having a width extending in an x-direction of an x-y-z coordinate system, a length extending in a y-direction, and a thickness extending in a z-direction....
10465251 lincRNA for the detection of esophageal cancer  
A method of analyzing tissue in a subject having or suspected of having cancer includes obtaining an expression profile from a sample of tissue obtained from the subject, wherein the expression...
10465229 System and method for detecting neural injury  
A detection system for determining pyruvate dehydrogenase (PDH) levels in a bodily sample includes at least one reaction solution for generating NAD+ upon combination with PDH in the bodily...
10459055 System and method for reduced field of view MR fingerprinting for parametric mapping  
The present disclosure provides systems and methods for magnetic resonance fingerprinting (MRF). The method including steps comprising acquiring a plurality of MRF signals from a plurality of...
10458895 Predicting response to pemetrexed chemotherapy in non-small cell lung cancer (NSCLC) with baseline computed tomography (CT) shape and texture features  
Methods, apparatus, and other embodiments predict response to pemetrexed based chemotherapy. One example apparatus includes an image acquisition circuit that acquires a radiological image of a...
10456575 Adjustable nerve electrode  
Example adjustable electrodes are described. One example adjustable electrode includes two or more contacts configured to selectively deliver high frequency alternating current (HFAC) to a nerve...
US20190322719 RAPID-ACTING INSULIN ANALOGUES OF ENHANCED STABILITY  
A two-chain insulin analogue contains a modified A-chain polypeptide and a modified B-chain polypeptide. The A-chain polypeptide comprises one or more of: a His or Glu substitution at position A8,...
10453191 Automated intravascular plaque classification  
Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (IVOCT) imagery. One example apparatus includes an image...
10450658 Alloy surface activation by immersion in aqueous acid solution  
A process for surface activation or depassivation of an article, in particular an alloy, by immersion of the alloy in an aqueous acid solution. The surface activation methods of the present...
10450615 Methods and compositions for detecting gastrointestinal and other cancers  
This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in...
US20190315805 TARGETED NONINVASIVE IMAGING PROBES OF EGFR EXPRESSING CELLS  
A probe for imaging EGFR expressing cells includes an EGFR targeting moiety, a reporter moiety, and a hydrophilic linker that links the EGFR targeting moiety to the reporter moiety. The...
US20190314300 COMPOUNDS AND METHODS OF PROMOTING MYELINATION  
The invention is a method of treating a subject with primary progressive or secondary progressive multiple sclerosis. The method comprises administering an effect amount of...
10441790 Systems and methods for closed loop control to ensure a constant current output with a changing load resistance  
A closed loop control system automatically ensures that an output of a device is constant. The system can receive an input to set a fixed value for a variable (e.g., a current, a heart rate, a...
10441782 Therapy delivery devices and methods for non-damaging neural tissue conduction block  
Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue....
10441225 Predicting disease recurrence following trimodality therapy in non-small cell lung cancer using computed tomography derived radiomic features and clinico-pathologic features  
Embodiments include operations, apparatus, methods and other embodiments that access a baseline CT image of a region of tissue (ROT) demonstrating non-small cell lung cancer (NSCLC), segment a...
10441215 Predicting immunotherapy response in non-small cell lung cancer with serial quantitative vessel tortuosity  
One embodiment includes an image acquisition circuit that accesses a pre-treatment and a post-treatment image of a region of tissue demonstrating non-small cell lung cancer (NSCLC), a segmentation...
US20190309372 METHODS AND COMPOSITIONS FOR DETECTING ESOPHAGEAL NEOPLASIAS AND/OR METAPLASIAS IN THE ESOPHAGUS  
The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers...
US20190309129 POLYBENZOXAZINE RESINS WITH HIGH HYDROGEN CONTENT, AND COMPOSITES THEREFROM  
A material with significant protection properties from galactic cosmic radiation and solar energetic particles. Hydrogen-rich benzoxazines which are particularly effective for shielding against...
US20190307832 INHIBITORS OF VALOSIN-CONTAINING PROTEIN AND METHODS OF USE  
A method of inhibiting aberrant valosin-containing protein (VCP) accumulation in the mitochondria of a nerve cell includes administering to the nerve cell a therapeutic agent that inhibits the...
US20190307687 MULTI-COMPONENT NANOCHAINS  
A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the...
US20190307584 INTELLIGENT PROSTHETIC SOCKET  
A system can be used to record real-time pressure and/or shear force data within a socket for a prosthetic device. The system includes a socket for a prosthetic device that can be designed to fit...
10438380 Systems and methods for translation of medical imaging using machine learning  
A medical image (24) with contrast of one imaging modality is emulated from images with other contrast characteristics. A plurality of input images (20) of a region of interest with the other...
10434194 PSMA targeted nanobubbles for diagnostic and therapeutic applications  
A PSMA targeted nanobubble includes a membrane that defines at least one internal void, which includes at least one gas, and at least one PSMA ligand coupled or conjugated to the membrane. The...
10434149 Synthetic platelets  
A method of promoting hemostasis in a subject in need thereof includes administering to the subject a biocompatible flexible nanoparticle that includes an outer surface and a plurality of peptides...
10434074 Peptide and small molecule agonists of EPHA and uses thereof  
Methods and compositions for activating an EphA receptor can be used for identifying therapeutic agents for cancer.
US20190304406 SYTEMS, METHODS, AND MEDIA FOR DISPLAYING INTERACTIVE AUGMENTED REALITY PRESENTATIONS  
Systems, methods, and media for displaying interactive augmented reality presentations are provided. In some embodiments, a system comprises: a plurality of head mounted displays, a first head...
US20190298883 INSOLUBLE NATIVE COLLAGEN FIBERS AND THEIR USE IN CELL AGGREGATES AND TISSUE CONSTRUCTS  
A method of forming an insoluble native collagen fiber additive, includes soaking the decellularized tissue powder, which includes collagen fibers, in acidic or basic, salt solution, enzymatically...
US20190298656 PARTICULATE COATED HYDROGEL MICROPARTICLES  
A composition includes a plurality of particulate coated hydrogel microparticles, each of the microparticles including a hydrogel inner core and a particulate shell defined by a plurality of solid...
10426820 Synthetic platelets  
A synthetic platelet including a biocompatible flexible nanoparticle, the nanoparticle having an outer surface and a plurality of site targeted peptides conjugated to the surface, the synthetic...
10426773 Systems pharmacology for treating ocular disorders  
A method of treating an ocular disorder in a subject includes administering to the subject subtherapeutic amounts of two or more agents that inhibit and/or blocks the activation of Gs- or...
US20190295721 SEQUENTIAL INTEGRATION OF ADVERSARIAL NETWORKS WITH HANDCRAFTED FEATURES (SANWICH): IDENTIFYING SITES OF PROGNOSTIC SIGNIFICANCE FOR PREDICTING CANCER RECURRENCE  
Embodiments discussed herein facilitate generation of a prognosis for a medical condition based on determination of one or more histomorphometric features for tiles of a whole slide image (WSI)...
US20190292063 AMMONIA SYNTHESIS USING PLASMA-PRODUCED ELECTRONS  
A method of ammonia synthesis is described that includes contacting a nitrogen gas-containing plasma with an aqueous solution, thereby forming ammonia from the nitrogen gas and water. The nitrogen...
US20190290717 COMPOSITIONS AND METHODS FOR TREATING HEART DISEASE AND/OR INJURY  
A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of...
US20190290233 DIFFERENTIAL ATLAS FOR IDENTIFYING SITES OF RECURRENCE (DISRN) IN PREDICTING ATRIAL FIBRILLATION RECURRENCE  
Embodiments access a set of radiological images acquired from a population of subjects, where a member of the set of radiological images includes a left atrium (LA) region; construct a statistical...
10420752 Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis  
A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
US20190287243 VASCULAR NETWORK ORGANIZATION VIA HOUGH TRANSFORM (VaNgOGH): A RADIOMIC BIOMARKER FOR DIAGNOSIS AND TREATMENT RESPONSE  
Embodiments access a radiological image of tissue having a tumoral volume and a peritumoral volume; define a vasculature associated with the tumoral volume; generate a Cartesian two-dimensional...
US20190285712 Systems and Methods for Acceleration of Dictionary Generation and Matching in Perfusion Analysis  
A method for determining quantitative parameters for dynamic contrast-enhanced MR data includes acquiring a set of contrast-enhanced MR data for a region of interest using a T1-weighted pulse...
US20190284176 COMPOSITIONS AND METHODS FOR TREATING CARDIOMYOPATHY  
A method of treating a cardiomyopathy in a subject in need thereof includes administering to the subject a therapeutically amount of a CCR2 inhibitor.
US20190282711 TARGETING PEPTIDES AND METHODS OF USE  
A compound includes at least one targeting peptide coupled to a detectable moiety. The targeting peptide binds to EDB-FN or EDA-FN and includes at least one of amino acid sequence selected from...
10416259 Nuclear magnetic resonance (NMR) fingerprinting  
Apparatus, methods, and other embodiments associated with NMR fingerprinting are described. One example NMR apparatus includes an NMR logic configured to repetitively and variably sample a (k, t,...
10413621 Composition and methods for imaging cells  
A composition for imaging a cell includes a first imaging probe and a second imaging probe that include respectively a first reporter moiety and a second reporter moiety. The first reporter moiety...
10413608 Thiobase compounds for photodynamic therapy  
A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside,...