Patents and Patent Applications from Case Western Reserve University


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9897675 Magnetic resonance fingerprinting (MRF) with simultaneous multivolume acquisition  
Magnetic resonance fingerprinting (MRF) with simultaneous multivolume acquisition (SMVA) is described. One example nuclear magnetic resonance (NMR) apparatus includes an NMR logic that...
9895668 Dispersion of particulate clusters via the rapid vaporization of interstitial liquid  
A process for dispersing agglomerates or clusters of particles utilizing pressure generated from volatilization of an interstitial liquid. More particularly, the method relates to infusing the...
US20180043291 MULTILAYER CELLULAR MEMBRANES FOR FILTRATION APPLICATIONS  
A filter includes a fibrous substrate having a plurality of coextruded first polymer material fibers and second polymer material fibers. Each of the first and second fibers are separated from each...
US20180042565 DUAL ENERGY X-RAY CORONARY CALCIUM GRADING  
Methods and apparatus for grading coronary calcium, including an example apparatus that includes a set of logics and a memory that stores a set of radiographic images. The set of logics includes...
9889291 Therapy delivery devices and methods for non-damaging neural tissue conduction block  
Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue....
9889199 PSMA ligands and uses thereof  
Compounds that are PSMA ligands, pharmaceutical compositions comprising these compounds, methods for treating and detecting cancers in a subject, methods for identifying cancer cells in a sample...
9889129 Method of modulating ribonucleotide reductase  
A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a ribonucleotide reductase allosteric modulator (RRAmod), the amount...
US20180035939 LOW FREQUENCY NON-INVASIVE SENSORIAL STIMULATION FOR SEIZURE CONTROL  
Example apparatus and methods reduce epileptic seizures in a human patient by non-invasively providing low frequency (e.g., 1-10 Hz) audio stimuli coordinated with low frequency (e.g., 1-10 Hz)...
9885557 Polarization sensitive optical coherence tomography using multiple polarization sensitive semiconductor optical amplifiers  
This disclosure relates to an OCT apparatus configured to generate to electromagnetic (e.g., optical) signals having two different polarization states. Two or more silicon optical amplifiers...
9884195 Delaying the onset of muscle fatigue associated with functional electrical stimulation  
The present invention relates a system that can configure a stimulus for functional electrical stimulation (“FES”) to maintain a constant muscle force while delaying the onset of muscle fatigue...
9884192 Onset-mitigating high-frequency nerve block  
A method of blocking signal transmission through a nerve with reduced onset activity includes applying an HFAC to an axon of a nerve to block the transmission of signals through the axon. The...
9883901 Characterizing ablation lesions using optical coherence tomography (OCT)  
Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes...
US20180033937 THERMOELECTRIC ENERGY HARVESTING FROM PAVEMENT STRUCTURE  
Electrically parallel thermoelectric modules (TEMs), especially induced multilayered TEMs, have the potential to stimulate the applications of TEMs to harvest energy from naturally existing...
US20180033138 ENTROPY-BASED RADIOGENOMIC DESCRIPTORS ON MAGNETIC RESONANCE IMAGING (MRI) FOR MOLECULAR CHARACTERIZATION OF BREAST CANCER  
Methods, apparatus, and other embodiments distinguish disease phenotypes and mutational status using co-occurrence of local anisotropic gradient orientations (CoLIAGe) and Laws features. One...
US20180030145 METHODS OF DETECTING CANCER  
A method of detecting the presence of glioblastomas and/or recurrent glioblastomas in a subject in need thereof includes isolating CD14+ cells from a blood sample of the subject and determining...
US20180025490 MULTI-PASS ADAPTIVE VOTING FOR NUCLEI DETECTION IN HISTOPATHOLOGICAL IMAGES  
Methods, apparatus, and other embodiments detect nuclei in histopathological images. One example method includes accessing a histopathology image that includes a plurality of pixels, generating a...
US20180025489 QUANTIFYING MASS EFFECT DEFORMATION WITH STRUCTURAL RADIOMICS IN BRAIN TUMOR PATIENTS  
Methods and apparatus quantify mass effect deformation in diagnostic images of patients demonstrating glioblastoma multiforme (GBM). One example apparatus includes an image acquisition circuit...
US20180021277 ANTI-VIRULENCE COMPOSITIONS AND METHODS  
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject an AgrA antagonist.
US20180015281 SYSTEM AND METHOD FOR ENSURING AIRWAY PATENCY WHEN ASLEEP  
One aspect of the present disclosure relates to a system that provides an alternative to traditional treatments for sleep apnea. The system allows to apply an electrical stimulus through an...
9869739 Heteronuclear nuclear magnetic resonance fingerprinting  
Apparatus, methods, and other embodiments associated with heteronuclear nuclear magnetic resonance fingerprinting (NMRfp) are described. One example apparatus includes individually controllable...
US20180012356 DISEASE CHARACTERIZATION FROM FUSED PATHOLOGY AND RADIOLOGY DATA  
Methods and apparatus distinguish invasive adenocarcinoma (IA) from in situ adenocarcinoma (AIS). One example apparatus includes a set of circuits, and a data store that stores three dimensional...
US20180008559 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS  
A method of treating a pervasive development disorder in a subject includes administering to the subject a therapeutically effective amount of an NMDAR antagonist, with an intermittent dosing regimen.
US20180000769 COMPOSITIONS AND METHODS FOR STIMULATING VENTILATORY AND/OR RESPIRATORY DRIVE  
A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a...
9854964 Measurement of biomechanical properties in an OCT image  
Systems and method are provided for evaluating a biomechanical property of tissue. A shear wave generator is configured to induce a shear wave in the tissue. An optical coherence tomography (OCT)...
US20170372497 SYSTEMS AND METHODS FOR TRANSLATION OF MEDICAL IMAGING USING MACHINE LEARNING  
A medical image (24) with contrast of one imaging modality is emulated from images with other contrast characteristics. A plurality of input images (20) of a region of interest with the other...
US20170369948 METHODS AND COMPOSITIONS FOR DETECTING COLORECTAL NEOPLASIAS  
The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for...
US20170369548 INSULIN ANALOGUES WITH SELECTIVE SIGNALING PROPERTIES AND REDUCED MITOGENICITY  
A two-chain insulin analogue contains Aspartic Acid at position B10 and penta-fluoro-Phenylalanine at position B24, optionally Histidine or Glutamic Acid at position A8, optionally additional...
US20170369322 KETYL RADICAL INDUCED PHOTOREDUCTION OF GRAPHENE OXIDE; GRAFTING OF METAL NANOPARTICLES ON GRAPHENE BY PHOTOREDUCTION  
Photoreduction of graphene oxide, by UV-generated ketyl radicals, to graphene. The photoreduction is versatile and can be carried out in solution, solid-state, and even in polymer composites....
9851421 Differential atlas for cancer assessment  
Methods and apparatus associated with producing a quantification of differences associated with biochemical recurrence (BcR) in a region of tissue demonstrating prostate cancer (PCa) are...
US20170360895 LONG-ACTING INSULIN ANALOGUE PREPARATIONS IN INSOLUBLE AND CRYSTALLINE FORMS  
A pharmaceutical formulation comprises an insulin analogue or a physiologically acceptable salt thereof, wherein the insulin analogue or a physiologically acceptable salt thereof contains an...
US20170360755 COMPOSITIONS AND METHODS OF MODULATING S-NITROSYLATION  
A method of treating disorders associated with NO/SNO deficiency or benefiting from increased SNO in a subject in need thereof includes administering to the subject an ADH inhibitor, AKR...
9844673 Stimulation of the forno-dorso-commissure (FDC) for seizure suppression and memory improvement  
Example apparatus and methods cause activation of target neural tissue through electrical stimulation of a connected white matter tract to reduce the hyper-excitability of the target neural tissue...
US20170352157 COMPUTERIZED ANALYSIS OF COMPUTED TOMOGRAPHY (CT) IMAGERY TO QUANTIFY TUMOR INFILTRATING LYMPHOCYTES (TILS) IN NON-SMALL CELL LUNG CANCER (NSCLC)  
Methods, apparatus, and other embodiments predict tumor infiltrating lymphocyte (TIL) density from pre-surgical computed tomography images of a region of tissue demonstrating non-small cell lung...
US20170351939 PREDICTING RESPONSE TO PEMETREXED CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) WITH BASELINE COMPUTED TOMOGRAPHY (CT) SHAPE AND TEXTURE FEATURES  
Methods, apparatus, and other embodiments predict response to pemetrexed based chemotherapy. One example apparatus includes an image acquisition circuit that acquires a radiological image of a...
US20170348438 MRP-14 TARGETING PEPTIDES AND USES THEREOF  
A peptide for targeting MRP-14 has an amino acid sequence at least 80% identical to amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO:...
9833518 Heteromultivalent particle compositions  
A composition for use in diagnostic and therapeutic applications includes a heteromultivalent nanoparticle or microparticle having an outer surface and a plurality of targeting moieties conjugated...
US20170340581 COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS  
A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a...
US20170335998 TUBULAR, EQUIPMENT AND METHOD OF FORMING THE SAME  
A tubular including a plurality of first-type layers; and a plurality of second-type layers each disposed between a pair of adjacent first-type layers, wherein the plurality of first-type layers...
US20170332973 MULTICHANNEL ULTRA-LOW NOISE AMPLIFIER  
The present disclose generally relates to a multichannel low-noise amplifier. At each input to the multichannel low-noise amplifiers, a plurality of transistors can be connected in parallel. This...
9822504 Systems, apparatuses and methods for assessing soil heave  
A method of assessing soil heave includes providing a plurality of determined values of a shear modulus of soil, the determined values being values of the shear modulus of the soil at different...
9821173 Anti-cancer agents and methods of use  
An anti-cancer agent includes Au(I) purinyl, indolyl, or azaindolyl analogues encapsulated in sterically hindered phosphine ligands.
9814720 Compositions and methods of inhibiting IL-17 expression of neutrophils  
A method of inhibiting IL-17 expression in neutrophils of a subject in need thereof includes administering to neutrophils of the subject a therapeutically effective amount of agent that inhibits...
US20170319098 SYSTEM AND METHOD FOR SPECTROSCOPIC MAGNETIC RESONANCE FINGERPRINTING  
The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of...
9810696 PGLYRP2 biomarker in idiopathic pneumonia syndrome  
A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the...
9802081 Bike system for use in rehabilitation of a patient  
A system for use in rehabilitation of a target patient is provided. The system includes at least two bicycle devices for use by the target patient and a second operator other than the target...
9801863 Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis  
A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
US20170309018 AUTOMATED INTRAVASCULAR PLAQUE CLASSIFICATION  
Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (IVOCT) imagery. One example apparatus includes an image...
US20170304361 HALOGENATED INSULIN ANALOGUES OF ENHANCED BIOLOGICAL POTENCY  
An insulin molecule comprises an Asp substitution at position B10, Glu at one or more of positions corresponding to A8, B28, and B29, and a halogenated phenylalanine at position B24. The analogue...
9797075 Polymer composite and method of forming same  
In accordance with one embodiment, a polymer composite comprises a filler and a matrix. The filler comprises an electrospun polymer mat. The matrix comprises a polymer film. The filler is arranged...
US20170298411 SYSTEM AND METHOD FOR DETECTING OF ALPHA-METHYLACYL-COA RACEMASE (AMACR) AND PROSTATE CANCER  
A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H2O2 upon combination with AMACR in the bodily...