Patents and Patent Applications from Case Western Reserve University


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US20170298411 SYSTEM AND METHOD FOR DETECTING OF ALPHA-METHYLACYL-COA RACEMASE (AMACR) AND PROSTATE CANCER  
A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H2O2 upon combination with AMACR in the bodily...
US20170296589 COMPOSITIONS AND METHODS FOR TREATING LUNG REMODELING DISEASES  
In one aspect, the present disclosure can relate to a method for treating a lung remodeling disease in a subject. One step of the method can include assaying one or more mesenchymal stem cells...
9790233 Compositions and methods of modulating 15-PGDH activity  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
9789116 Compositions and methods of modulating short-chain dehydrogenase activity  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
US20170293003 SYSTEM AND METHOD FOR IMPROVED RF SYSTEM PERFORMANCE IN MRI SYSTEMS  
An apparatus, a system, and a chip are provided for improving RF system performance in MRI systems. The apparatus includes a radio-frequency (RF) coil array disposed at least partially in a coil...
9782363 Anti-virulance compositions and methods  
A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical...
US20170282474 MULTILAYER POLYMER DIELECTRIC FILM  
A multilayer polymer dielectric film includes a stack of coextruded, alternating first dielectric layers and second dielectric layers that receive electrical charge. The first dielectric layers...
US20170281931 NERVE CUFF FOR IMPLANTABLE ELECTRODE  
A system for functional electrical stimulation can include a cuff and a stimulation device. The cuff can be attachable to a nerve or a muscle filament. The cuff can include an elastic collar...
US20170281789 PHOTODYNAMIC THERAPY COMPOSITION  
A phthalocyanine compound or targeted conjugate thereof having the formula (I).
9778245 Diagnostic devices and methods  
A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet...
9777106 Bisphenol polymer precursor replacements  
Use of biologically-derived polyphenols for the preparation of epoxy resins is described. Examples of biologically-derived polyphenols include resveratrol, genistein, daidzein, and polyphenols...
9770500 S-nitrosylation of glucosylating toxins and uses therefor  
Provided herein are methods for ameliorating the pathophysiology cysteine protease exotoxin comprising the step of administering to said individual an effective dose of an S-nitrosylating agent...
US20170268008 DIAGNOSTIC AND THERAPEUTIC TARGETING OF DNMT-1 ASSOCIATED RNA IN HUMAN CANCER  
A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of DNMT1-associated RNA and/or the...
US20170266071 FITTING SYSTEM AND METHOD FOR MODULAR PRESSURE RELIEF CUSHION  
A high-performance, low-cost modular cushion using range of novel dynamically responsive materials has been designed and developed for use in seating pressure relief. The use of individual...
US20170265463 SPORICIDAL COMPOSITION  
A sporicidal composition includes an acidified short or medium chain, linear or branched alcohol having a pH effective to promote killing of spore forming bacteria and bacterial spores.
9767555 Disease characterization from fused pathology and radiology data  
Methods and apparatus associated with distinguishing invasive adenocarcinoma (IA) from in situ adenocarcinoma (AIS) are described. One example apparatus includes a set of logics, and a data store...
9764136 Clinical decision support system  
Example apparatus and methods concern a next generation clinical decision support system (ngCDSS) for the management of neurological conditions (e.g., advanced Parkinson's disease (PD))....
US20170260341 CATIONIC ULTRAVIOLET CURING OF RESINS WITH ONIUM SALT  
Disclosed herein is a method of forming a photocurable polymer system. The method includes providing a polymer, providing a diaryl iodonium salt, blending said polymer and diaryl iodonium salt,...
9758563 Insulin analogues with chlorinated amino acids and nucleic acids encoding the same  
An insulin analog comprises a B-chain polypeptide incorporating a chlorinated phenylalanine. The chlorinated phenylalanine may be located at position B24. The chlorinated phenylalanine may be...
US20170252326 COMPOSITIONS AND METHODS OF INHIBITING METALLO-BETA-LACTAMASES  
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one...
US20170248541 SENSOR FOR VOLATILE ORGANIC COMPOUND DETECTION  
A sensor for detecting volatile organic compounds (VOCs) includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate,...
US20170247801 BROMIDE REMOVAL FROM AQUEOUS SOLUTIONS  
Systems and processes for removing and purifying bromide from an aqueous bromide solution are described. Electrochemistry is used to either convert bromide to bromine to allow its extraction in an...
US20170246456 PATTERNED STIMULATION INTENSITY FOR NEURAL STIMULATION  
One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation...
9747789 Magnetic resonance imaging with switched-mode current-source amplifier having gallium nitride field effect transistors for parallel transmission in MRI  
Example systems, apparatus, circuits, and other embodiments described herein concern parallel transmission in MRI. One example apparatus includes at least two enhanced mode gallium nitride (eGaN)...
US20170241990 PERICYTE ASSAY FOR TRANSENDOTHELIAL MIGRATION  
A test animal for identifying blood vessel transendothelial migration-affecting factors or agents is described. The test animal comprises an implanted tissue mimicking model with a composite...
US20170239325 AUTOLOGOUS HIV-1 PROTEINS FOR THE TREATMENT OF LATENT HIV-1 INFECTION  
A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes the steps of: preparing at least one HIV-1 protein coding sequence from a sample obtained from the subject,...
9734432 Reducing acquisition time  
Systems, methods, apparatus, and other embodiments associated with reducing imaging acquisition time are described. One example method includes accessing an under-sampled data set and a library of...
9731975 Alternative methods for the synthesis of organosilicon compounds  
A method of forming chloro-substituted silanes from the reaction of an alkoxysilane with a chlorinating agent in the optional presence of a catalyst is provided. More specifically,...
US20170227495 BIOCHIPS TO DIAGNOSE HEMOGLOBIN DISORDERS AND MONITOR BLOOD CELLS  
A biochip compatible with very small blood sample volumes is used for delecting for detecting hemoglobin disorders and monitoring disorders associated with aberrant blood cell deformability and...
US20170224848 TARGETING PEPTIDES AND METHODS OF USE  
A compound includes at least one targeting peptide coupled to a detectable moiety. The targeting peptide binds to EDB-FN or EDA-FN and includes at least one of amino acid sequence selected from...
US20170224678 INHIBITORS OF BCL-2  
Compounds and pharmaceutical compositions thereof for inducing apoptosis in a cell expressing Bcl-2 and IP3R and their use in a method for treating neoplastic disorders in a subject.
9725493 N-terminal truncated insulin analogues  
An insulin analogue contains a foreshortened B-chain polypeptide lacking residues B1-B3 and optionally contains an additional substitution in the C-terminal B23-B30 segment of the B-chain. The...
9724900 Gas separation membrane  
A method of fabricating a gas separation membrane includes providing a coextruded multilayer film that includes a first polymer layer formed of a first polymer material and a second polymer layer...
US20170216438 PLANT VIRUS PARTICLES FOR DELIVERY OF PHOTOSENSITIVE AGENTS  
Photodynamic virus particles including a plant virus particle associated with a photosensitizing agent are described. Methods of treating cancer in a subject by administering to the subject a...
US20170216265 INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS  
A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
US20170216206 MULTI-COMPONENT NANOCHAINS  
A multi-component nanochain for use in diagnostic and therapeutic applications includes at least three nanoparticles linked together to form the nanochain. At least one nanoparticle of the...
US20170209425 METHODS AND COMPOSITIONS FOR TREATING PATHOLOGIES ASSOCIATED WITH BDNF SIGNALING  
A method of treating non-neurodegenerative pathologies associated with derangement in brain-derived neurotrophic factor signaling in the brain stem includes administering to the subject an amount...
US20170209419 METHODS OF TREATING RESPIRATORY DISORDERS  
A method of treating a hyperoxia induced disease or disorder associated with GSNO deficiency in a subject in need thereof includes administering to the subject a therapeutically effective amount...
9713708 Nerve cuff for implantable electrode  
A flat interface nerve electrode provides a plurality of electrical contacts embedded in a non-conductive cuff structure, which acts to gently and non-evasively redefine the geometry of a nerve...
US20170204470 METHODS AND COMPOSITIONS FOR DETECTING GASTROINTESTINAL AND OTHER CANCERS  
This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in...
US20170196908 COMPOSITIONS AND METHODS OF TREATING DIABETIC RETINOPATHY  
A method of treating diabetic retinopathy in a subject in need thereof includes administering to the subject a therapeutically effective amount of one or more agents that act as a trap of reactive...
US20170193657 PREDICTION OF RECURRENCE OF NON-SMALL CELL LUNG CANCER WITH TUMOR INFILTRATING LYMPHOCYTE (TIL) GRAPHS  
Methods and apparatus predict non-small cell lung cancer (NSCLC) recurrence using radiomic features extracted from digitized hematoxylin and eosin (H&E) stained slides of a region of tissue...
US20170193655 RADIOMIC FEATURES ON DIAGNOSTIC MAGNETIC RESONANCE ENTEROGRAPHY  
Methods, apparatus, and other embodiments associated with predicting Crohn's Disease (CD) patient response to immunosuppressive (IS) therapy using radiomic features extracted from diagnostic...
US20170193175 PREDICTION OF RECURRENCE OF NON-SMALL CELL LUNG CANCER  
Methods, apparatus, and other embodiments associated with predicting non-small cell lung cancer (NSCLC) patient response to adjuvant chemotherapy therapy using radiomic features extracted from...
US20170192006 BIOMARKERS FOR HUMAN MONOCYTE MYELOID0DERIVED SUPPRESOR CELLS  
A method for diagnosing an increased risk of a cancer in a subject includes the steps of obtaining a blood sample from the subject and determining, in the blood sample, a level of two or more of...
US20170191942 SYSTEMS AND METHODS FOR DETECTING AN OPTICAL CHANGE INDICATING THE PRESENCE OF AN ANALYTE  
One aspect of the present disclosure relates to an analyte sensor device. The analyte sensor device can include an optode layer that undergoes an optical change in the presence of an analyte. The...
US20170189366 METHOD FOR TREATING DISORDERS RELATED TO COMPLEMENT ACTIVATION  
A method for treating or preventing a complement activated T-cell mediated disorder in a subject includes administering a therapeutically effective amount of a pharmaceutical composition to the...
9694181 Methods of treatment of a neurological disorder using electrical nerve conduction block  
Described herein are methods of treating various neurological disorders using electrical nerve conduction block (ENCB) without causing electrochemical damage. Examples of the various neurological...
US20170185730 MACHINE LEARNING APPROACH TO SELECTING CANDIDATES  
Example apparatus and methods concern a clinical decision support system for the selection of candidates. A clinical decision support system includes a candidate data logic that receives...
US20170184564 SENSOR FOR NITRIC OXIDE DETECTION  
A sensor for detecting nitric oxide includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate, a dielectric layer...