Patents and Patent Applications from Case Western Reserve University


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US20180169408 NEURAL PROSTHESIS SYSTEM AND METHOD OF CONTROL  
Multiple designs, systems, methods and processes for control using electrical signals recorded from clinically paralyzed muscles and nerves are presented. The discomplete neural prosthesis system...
US20180169208 PROTECTIVE ANTIGEN COMPLEXES WITH INCREASED STABILITY AND USES THEREOF  
Immunogenic compositions against Bacillus anthracis comprising a stabilized protective antigen complex are disclosed. The stabilized complex comprises protective antigen protein and capillary...
10000578 Method for production of cellulose nanocrystals from Miscathus giganteus and composites therefrom  
Methods for isolating cellulose nanocrystals (CNCs) from the plant Miscanthus Giganteus (MxG). Impressive yields are obtained through a combination of processing steps including base hydrolysis,...
US20180164240 SENSOR FOR DETECTION OF ANALYTES  
A sensor for the detection of an analyte in a fluid includes an electrode having a detection surface, a polydopamine layer adhered to the electrode detection surface; and optionally a receptor...
US20180161391 INHIBITORS OF BCL-2  
A protease resistant polypeptide includes an amino acid sequence that has a sequence identity at least 80% homologous to about 10 to 80 consecutive amino acids of SEQ ID NO:1.
US20180160660 MOUSE MODEL OF RETINAL DEGENERATION  
The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In...
9997285 Transformation enabled nitride magnets absent rare earths and a process of making the same  
A process for producing an ordered martensitic iron nitride powder that is suitable for use as a permanent magnetic material is provided. The process includes fabricating an iron alloy powder...
9995701 Capacitive sensing apparatuses, systems and methods of making same  
A sensor system can be configured to perform dielectric spectroscopy (DS). For example, the system can include a sensor configured to measure dielectric permittivity of a fluid in response to an...
9994964 System and method for removal of metals from solution  
A process to extract metal ions and potentially other hazardous species present in solution to levels low enough to make it suitable for use and/or to quantify the levels of these contaminants in...
US20180156596 POLARIZATION SENSITIVE OPTICAL COHERENCE TOMOGRAPHY  
This disclosure relates to an OCT apparatus configured to generate to electromagnetic (e.g., optical) signals having two different polarization states. Two or more silicon optical amplifiers...
US20180153608 CHARACTERIZING ABLATION LESIONS USING OPTICAL COHERENCE TOMOGRAPHY (OCT)  
Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes...
9989604 Multiturn MRI coils in combination with current mode class D amplifiers  
Example systems, apparatus, and circuits described herein concern a multi-turn transmit surface coil used in parallel transmission in high field MRI. One example apparatus includes a balun network...
9988680 Non-natural nucleosides as theranostic agents  
A composition for monitoring DNA damage includes a 3-ethynyl-5-nitroindolyl-2′-deoxyribose compound or pharmaceutically acceptable salt thereof and a detectable moiety with a click-reactive...
9988451 HIV-1 vaccine  
A method for inducing an immune response against HIV in a subject includes the step of preparing an HIV-1 gp120 envelope protein coding sequence particle having an N425K mutation, introducing the...
9987379 Molecular probes for imaging of myelin  
A molecular probe for labeling myelin includes a fluorescent trans-stilbene derivative.
9987316 Probiotic controlling fungi and uses thereof  
A method for controlling detrimental oral organisms in various individuals includes administering a priobiotic composition that includes one or more species or strains of beneficial fungi and/or...
US20180146853 NOVEL HIGH-CONTACT DENSITY ELECTRODE AND FABRICATION TECHNIQUE FOR AN IMPLANTABLE CUFF DESIGN  
A method and an electrode for monitoring electrical activity in a nerve are provided along with a method of fabricating such an electrode. The electrode includes a cuff formed from a...
9984462 Disease characterization from fused pathology and radiology data  
Methods and apparatus distinguish invasive adenocarcinoma (IA) from in situ adenocarcinoma (AIS). One example apparatus includes a set of circuits, and a data store that stores three dimensional...
9984212 Group-sparse nonnegative supervised canonical correlation analysis (GNCCA)  
Methods, apparatus, application specific integrated circuits (ASIC)s and other embodiments associated with analyzing a cancerous prostate using group-sparse non-negative canonical correlation...
9980960 Methods for determining the risk of cardiovascular disease in a subject having a chronic viral infection  
A method for determining the risk of cardiovascular disease in a subject having a chronic viral infection includes determining a level of ectonucleotide pyrophosphatase/phosphodiesterase-2 (ENPP2)...
9980645 High-contact density electrode and fabrication technique for an implantable cuff design  
A method and an electrode for monitoring electrical activity in a nerve are provided along with a method of fabricating such an electrode. The electrode includes a cuff formed from a...
9975940 Long-acting single-chain insulin analogues  
A single-chain insulin analogue containing a basic side chain at position A8 (Arginine, Histidine, Lysine, or Ornithine), a basic side chain at position B29 (Arginine, Histidine, Lysine, or...
9974947 Method to treat pain through electrical stimulation of nerves  
Methods of treating pain are disclosed, wherein a non-pulsed, low-frequency electrical current is applied to the nerve carrying the pain signals in order to suppress transmission of those signals....
US20180135061 METHODS OF MODULATING mRNA STABILITY AND PROTEIN EXPRESSION  
A synthetic cDNA which encodes a protein wherein at least one optimal or non-optimal codon in a wild type DNA encoding the protein has been replaced respectively with one or more non-optimal...
US20180134714 COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS  
A method of treating an ocular disorder in a subject associated with aberrant all-trans-retinal clearance in the retina, the method comprising administering to the subject a therapeutically...
US20180133950 DEVICES AND METHODS FOR PRODUCTION OF HOLLOW CYLINDRICAL STRUCTURES AND HOLLOW CYLINDRICAL STRUCTURES  
A device suitable for constructing hollow cylindrical structures, particularly useful as medical devices. The devices are versatile in nature and can fabricate hollow cylindrical structures having...
US20180133849 TI-BASED FILLER ALLOY COMPOSITIONS  
Alloys comprising titanium as the principal component and which melt between 700 and 1400 degrees C. are disclosed to have favorable characteristics for braze-joining. The alloys form strong,...
US20180133304 CANCER IMMUNOTHERAPY USING VIRUS PARTICLES  
A method of treating cancer in a subject in need thereof includes administering in situ to the cancer a therapeutically effective amount of a virus or virus-like particle.
9971009 Magnetic resonance imaging (MRI) with auto-detection and adaptive encodings for offset frequency scanning  
Example apparatus and methods provide improved resolution over conventional magnetic resonance imaging (MRI) that is affected by the presence of metal (e.g., prosthetic hip) in the MRI field of...
9969974 Differntiation method for production of glial cell population  
The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these oligodendrocyte progenitor cells in...
9969620 Nanoscale diamond particles and method of forming nanoscale diamond particles  
A method of forming nanoscale diamond particles comprises providing C2 and CH radicals at a low pressure, and nucleating the C2 and CH radicals to form carbon nanoparticles comprising a diamond...
9968296 Wearable socio-biosensor device  
A wearable socio-biosensor device can include a plurality of sensors to detect bio-behavioral data of a subject, social data related to a proximity of the subject to other persons wearing...
US20180129911 HISTOMORPHOMETRIC CLASSIFIER TO PREDICT CARDIAC FAILURE FROM WHOLE-SLIDE HEMATOXYLIN AND EOSIN STAINED IMAGES  
Methods, apparatus, and other embodiments predict heart failure from WSIs of cardiac histopathology using a deep learning convolutional neural network (CNN). One example apparatus includes a...
US20180127830 FLUORESCENT PROBES FOR ABASIC SITE DETECTION  
A fluorescent probe for binding to and detection of AP sites of DNA includes the following formula: F-L-X where F is a fluorescent moiety, X is an aminooxy group (—ONH2), and L is a linker that...
US20180125829 INHIBITORS OF SHORT-CHAIN DEHYDROGENASE ACTIVITY FOR MODULATING HEMATOPOIETIC STEM CELLS AND HEMATOPOIESIS  
A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
9964616 Fast group matching for magnetic resonance fingerprinting reconstruction  
Methods, apparatus, and other embodiments associated with producing a quantitative parameter map using magnetic resonance fingerprinting (MRF) are described. One example apparatus includes a data...
9962462 Dry spray on hemostatic system  
The invention provides for dry spray compositions comprising co-polymers comprising a core, water-soluble polymer and a peptide.
US20180123140 N-DOPED CARBON NANOMATERIALS AS CATALYSTS FOR OXYGEN REDUCTION REACTION IN ACIDIC FUEL CELLS  
Provided is a membrane electrode assembly and a fuel cell comprising such assemblies. The membrane electrode assembly comprises a polymer electrolyte membrane disposed between an anode and a...
US20180119006 SUSPENDING PROPPANTS WITH POLYMERIZED HYDROGELS  
Hydrogel-coated proppants and methods for manufacture thereof. In preferred embodiments, the hydrogel coating is covalently attached and crosslinked to the proppant substrate in a core-shell...
US20180118756 COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
US20180117321 ACTIVATION MAP BASED INDIVIDUALIZED PLANNING FOR DEEP BRAIN STIMULATION  
Example apparatus and methods plan and control neuro-modulation of a distributed multi-region network in a brain. A location for a deep brain stimulation (DBS) electrode that participates in...
US20180117314 THERAPY DELIVERY DEVICES AND METHODS FOR NON-DAMAGING NEURAL TISSUE CONDUCTION BLOCK  
Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue....
9957333 Anti-CEP antibody or fragment thereof  
An isolated anti-carboxyethylpyrrole (anti-CEP) antibody or antigen binding portion thereof includes a heavy chain variable domain that includes three CDRs having at least 90% sequence identity to...
9955907 Low frequency non-invasive sensorial stimulation for seizure control  
Example apparatus and methods reduce epileptic seizures in a human patient by non-invasively providing low frequency (e.g., 1-10 Hz) audio stimuli coordinated with low frequency (e.g., 1-10 Hz)...
US20180112226 METHODS OF MODULATING NUCLEIC ACID STABILITY AND PROTEIN EXPRESSION  
A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been replaced respectively with one or more...
US20180110989 SYSTEMS AND METHODS THAT USE FEEDBACK-BASED NEURAL STIMULATION FOR BLOOD PRESSURE CONTROL  
The present disclose generally relates to a system that controls blood pressure based on feedback-based neural stimulation. The system can include an electrode implantable within a nerve (e.g., an...
US20180110886 MOLECULAR PROBES AND METHODS OF USE  
A molecular probe includes the following formula: P-L-C wherein P is a EDB-FN targeting peptide, C is a contrast agent; and L is a non-peptide linker that covalently links the peptide to the...
9949995 Compositions and methods of treating of bacterial infections with β-lactamase inhibitors  
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one...
US20180108525 Method for Forming a Thin Film Comprising an Ultrawide Bandgap Oxide Semiconductor  
A method is disclosed for depositing a high-quality thin films of ultrawide bandgap oxide semiconductors at growth rates that are higher than possible using prior-art methods. Embodiments of the...
US20180106817 PROTEIN BIOMARKERS AND THERAPEUTIC TARGETS FOR RENAL DISORDERS  
The present invention relates to a method of diagnosing a renal disorder. The method includes the steps of: (1) obtaining a biological sample from a subject; and (2) determining, in the biological...