Patents and Patent Applications from Case Western Reserve University


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US20170352157 COMPUTERIZED ANALYSIS OF COMPUTED TOMOGRAPHY (CT) IMAGERY TO QUANTIFY TUMOR INFILTRATING LYMPHOCYTES (TILS) IN NON-SMALL CELL LUNG CANCER (NSCLC)  
Methods, apparatus, and other embodiments predict tumor infiltrating lymphocyte (TIL) density from pre-surgical computed tomography images of a region of tissue demonstrating non-small cell lung...
US20170351939 PREDICTING RESPONSE TO PEMETREXED CHEMOTHERAPY IN NON-SMALL CELL LUNG CANCER (NSCLC) WITH BASELINE COMPUTED TOMOGRAPHY (CT) SHAPE AND TEXTURE FEATURES  
Methods, apparatus, and other embodiments predict response to pemetrexed based chemotherapy. One example apparatus includes an image acquisition circuit that acquires a radiological image of a...
US20170348438 MRP-14 TARGETING PEPTIDES AND USES THEREOF  
A peptide for targeting MRP-14 has an amino acid sequence at least 80% identical to amino acid sequence selected from the group consisting of SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO:...
9833518 Heteromultivalent particle compositions  
A composition for use in diagnostic and therapeutic applications includes a heteromultivalent nanoparticle or microparticle having an outer surface and a plurality of targeting moieties conjugated...
US20170340581 COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS  
A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue includes administering to the subject a therapeutically effective amount of a...
US20170335998 TUBULAR, EQUIPMENT AND METHOD OF FORMING THE SAME  
A tubular including a plurality of first-type layers; and a plurality of second-type layers each disposed between a pair of adjacent first-type layers, wherein the plurality of first-type layers...
US20170332973 MULTICHANNEL ULTRA-LOW NOISE AMPLIFIER  
The present disclose generally relates to a multichannel low-noise amplifier. At each input to the multichannel low-noise amplifiers, a plurality of transistors can be connected in parallel. This...
9822504 Systems, apparatuses and methods for assessing soil heave  
A method of assessing soil heave includes providing a plurality of determined values of a shear modulus of soil, the determined values being values of the shear modulus of the soil at different...
9821173 Anti-cancer agents and methods of use  
An anti-cancer agent includes Au(I) purinyl, indolyl, or azaindolyl analogues encapsulated in sterically hindered phosphine ligands.
9814720 Compositions and methods of inhibiting IL-17 expression of neutrophils  
A method of inhibiting IL-17 expression in neutrophils of a subject in need thereof includes administering to neutrophils of the subject a therapeutically effective amount of agent that inhibits...
US20170319098 SYSTEM AND METHOD FOR SPECTROSCOPIC MAGNETIC RESONANCE FINGERPRINTING  
The present disclosure relates to a method for performing phosphorous-31 spectroscopic magnetic resonance fingerprinting (MRF). The method comprises performing a pulse sequence using a series of...
9810696 PGLYRP2 biomarker in idiopathic pneumonia syndrome  
A method for characterizing the risk a subject will develop an autoimmune and/or alloimmune disease following tissue transplant includes obtaining a biological sample from the subject, wherein the...
9802081 Bike system for use in rehabilitation of a patient  
A system for use in rehabilitation of a target patient is provided. The system includes at least two bicycle devices for use by the target patient and a second operator other than the target...
9801863 Inhibitors of short-chain dehydrogenase activity for modulating hematopoietic stem cells and hematopoiesis  
A method of modulating hematopoietic stem cells and hematopoiesis includes administering to a subject in need thereof a 15-PGDH inhibitor.
US20170309018 AUTOMATED INTRAVASCULAR PLAQUE CLASSIFICATION  
Methods and apparatus automatically classify intravascular plaque using features extracted from intravascular optical coherence tomography (IVOCT) imagery. One example apparatus includes an image...
US20170304361 HALOGENATED INSULIN ANALOGUES OF ENHANCED BIOLOGICAL POTENCY  
An insulin molecule comprises an Asp substitution at position B10, Glu at one or more of positions corresponding to A8, B28, and B29, and a halogenated phenylalanine at position B24. The analogue...
9797075 Polymer composite and method of forming same  
In accordance with one embodiment, a polymer composite comprises a filler and a matrix. The filler comprises an electrospun polymer mat. The matrix comprises a polymer film. The filler is arranged...
US20170298411 SYSTEM AND METHOD FOR DETECTING OF ALPHA-METHYLACYL-COA RACEMASE (AMACR) AND PROSTATE CANCER  
A detection system for determining alpha-methylacyl-CoA (AMACR) levels in a bodily sample includes at least one reaction solution for generating H2O2 upon combination with AMACR in the bodily...
US20170296589 COMPOSITIONS AND METHODS FOR TREATING LUNG REMODELING DISEASES  
In one aspect, the present disclosure can relate to a method for treating a lung remodeling disease in a subject. One step of the method can include assaying one or more mesenchymal stem cells...
9790233 Compositions and methods of modulating 15-PGDH activity  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
9789116 Compositions and methods of modulating short-chain dehydrogenase activity  
Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH...
9788712 Device and method for determining the presence of middle ear fluid  
A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source...
US20170293003 SYSTEM AND METHOD FOR IMPROVED RF SYSTEM PERFORMANCE IN MRI SYSTEMS  
An apparatus, a system, and a chip are provided for improving RF system performance in MRI systems. The apparatus includes a radio-frequency (RF) coil array disposed at least partially in a coil...
9782363 Anti-virulance compositions and methods  
A method of reducing the virulence of a bacterium that expresses accessory gene regulator A (AgrA) or an ortholog of AgrA includes administering to the bacterium an amount of a pharmaceutical...
US20170282474 MULTILAYER POLYMER DIELECTRIC FILM  
A multilayer polymer dielectric film includes a stack of coextruded, alternating first dielectric layers and second dielectric layers that receive electrical charge. The first dielectric layers...
US20170281931 NERVE CUFF FOR IMPLANTABLE ELECTRODE  
A system for functional electrical stimulation can include a cuff and a stimulation device. The cuff can be attachable to a nerve or a muscle filament. The cuff can include an elastic collar...
US20170281789 PHOTODYNAMIC THERAPY COMPOSITION  
A phthalocyanine compound or targeted conjugate thereof having the formula (I).
9778245 Diagnostic devices and methods  
A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet...
9777106 Bisphenol polymer precursor replacements  
Use of biologically-derived polyphenols for the preparation of epoxy resins is described. Examples of biologically-derived polyphenols include resveratrol, genistein, daidzein, and polyphenols...
9770500 S-nitrosylation of glucosylating toxins and uses therefor  
Provided herein are methods for ameliorating the pathophysiology cysteine protease exotoxin comprising the step of administering to said individual an effective dose of an S-nitrosylating agent...
US20170268008 DIAGNOSTIC AND THERAPEUTIC TARGETING OF DNMT-1 ASSOCIATED RNA IN HUMAN CANCER  
A method for treating cancer in a subject in need thereof includes administering to cancer cells of the subject an agent effective to modulate the level of DNMT1-associated RNA and/or the...
US20170266071 FITTING SYSTEM AND METHOD FOR MODULAR PRESSURE RELIEF CUSHION  
A high-performance, low-cost modular cushion using range of novel dynamically responsive materials has been designed and developed for use in seating pressure relief. The use of individual...
US20170265463 SPORICIDAL COMPOSITION  
A sporicidal composition includes an acidified short or medium chain, linear or branched alcohol having a pH effective to promote killing of spore forming bacteria and bacterial spores.
9767555 Disease characterization from fused pathology and radiology data  
Methods and apparatus associated with distinguishing invasive adenocarcinoma (IA) from in situ adenocarcinoma (AIS) are described. One example apparatus includes a set of logics, and a data store...
9764136 Clinical decision support system  
Example apparatus and methods concern a next generation clinical decision support system (ngCDSS) for the management of neurological conditions (e.g., advanced Parkinson's disease (PD))....
US20170260341 CATIONIC ULTRAVIOLET CURING OF RESINS WITH ONIUM SALT  
Disclosed herein is a method of forming a photocurable polymer system. The method includes providing a polymer, providing a diaryl iodonium salt, blending said polymer and diaryl iodonium salt,...
9758563 Insulin analogues with chlorinated amino acids and nucleic acids encoding the same  
An insulin analog comprises a B-chain polypeptide incorporating a chlorinated phenylalanine. The chlorinated phenylalanine may be located at position B24. The chlorinated phenylalanine may be...
US20170252326 COMPOSITIONS AND METHODS OF INHIBITING METALLO-BETA-LACTAMASES  
A method of treating a bacterial infection in a subject in need thereof includes administering to the subject therapeutically effective amounts of at least one β-lactam antibiotic and at least one...
US20170248541 SENSOR FOR VOLATILE ORGANIC COMPOUND DETECTION  
A sensor for detecting volatile organic compounds (VOCs) includes a substrate, a working electrode formed on a surface of the substrate, a counter electrode formed on the surface of the substrate,...
US20170247801 BROMIDE REMOVAL FROM AQUEOUS SOLUTIONS  
Systems and processes for removing and purifying bromide from an aqueous bromide solution are described. Electrochemistry is used to either convert bromide to bromine to allow its extraction in an...
US20170246456 PATTERNED STIMULATION INTENSITY FOR NEURAL STIMULATION  
One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation...
9747789 Magnetic resonance imaging with switched-mode current-source amplifier having gallium nitride field effect transistors for parallel transmission in MRI  
Example systems, apparatus, circuits, and other embodiments described herein concern parallel transmission in MRI. One example apparatus includes at least two enhanced mode gallium nitride (eGaN)...
US20170241990 PERICYTE ASSAY FOR TRANSENDOTHELIAL MIGRATION  
A test animal for identifying blood vessel transendothelial migration-affecting factors or agents is described. The test animal comprises an implanted tissue mimicking model with a composite...
US20170239325 AUTOLOGOUS HIV-1 PROTEINS FOR THE TREATMENT OF LATENT HIV-1 INFECTION  
A method of reducing a latent HIV-specific memory-CD4+ T cell pool in a subject includes the steps of: preparing at least one HIV-1 protein coding sequence from a sample obtained from the subject,...
9734432 Reducing acquisition time  
Systems, methods, apparatus, and other embodiments associated with reducing imaging acquisition time are described. One example method includes accessing an under-sampled data set and a library of...
9731975 Alternative methods for the synthesis of organosilicon compounds  
A method of forming chloro-substituted silanes from the reaction of an alkoxysilane with a chlorinating agent in the optional presence of a catalyst is provided. More specifically,...
US20170227495 BIOCHIPS TO DIAGNOSE HEMOGLOBIN DISORDERS AND MONITOR BLOOD CELLS  
A biochip compatible with very small blood sample volumes is used for delecting for detecting hemoglobin disorders and monitoring disorders associated with aberrant blood cell deformability and...
US20170224848 TARGETING PEPTIDES AND METHODS OF USE  
A compound includes at least one targeting peptide coupled to a detectable moiety. The targeting peptide binds to EDB-FN or EDA-FN and includes at least one of amino acid sequence selected from...
US20170224678 INHIBITORS OF BCL-2  
Compounds and pharmaceutical compositions thereof for inducing apoptosis in a cell expressing Bcl-2 and IP3R and their use in a method for treating neoplastic disorders in a subject.
9725493 N-terminal truncated insulin analogues  
An insulin analogue contains a foreshortened B-chain polypeptide lacking residues B1-B3 and optionally contains an additional substitution in the C-terminal B23-B30 segment of the B-chain. The...