Patents and Patent Applications from Case Western Reserve University


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5214138 Imidazopyridinium compound and processes for isolating, identifying, and chemically synthesizing same  
The present invention is directed to a novel imidazo [4,5b] pyridinium molecule composed of a lysine and an arginine residue crosslinked with a pentose sugar. The novel imidazo [4,5b] pyridinium...
5202120 Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes  
The present invention relates to "activated" immature astrocytes and the methods of utilizing the activated immature astrocytes as a means for promoting Pursuant to the provisions of 35 U.S.C....
5199430 Micturitional assist device  
Cuff electrodes (40a, 40b) are surgically implanted around S3 sacral ventral root nerve trunks (16a, 16b). The sacral ventral roots have smaller diameter nerve fibers (20a, 20b) which convey action...
5183914 Alkoxysilanes and oligomeric alkoxysiloxanes by a silicate-acid route  
The present invention relates to a novel method of preparing alkoxysilanes and oligomeric alkoxysiloxanes. The method comprises reacting a metal silicate with an acid selected from the group...
5167229 Functional neuromuscular stimulation system  
An input command controller (A) provides logic function selection signals and proportional signals. The signals are generated by movement of a ball member (12) and socket member (14) relative to...
5145859 Methods of treating interstitial cystitis and urethral syndrome  
According to the invention there is provided various methods of treating mammalian interstitial cystitis and/or urethral syndrome through the use of Nifedipine, a calcium channel antagonist which...
5132231 Carbon monoxide detector using a derivative of Ni(TBC)  
A carbon monoxide detecting sensor of a derivative of Ni(TBC) which reacts with carbon monoxide to form a carbon monoxide adduct with a concomitant change in color.
5124918 Neural-based autonomous robotic system  
A system for achieving ambulatory control of a multi-legged system employs stimulus and response-based modeling. A adapted neural network-based system is employed for dictating motion...
5112457 Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of biomedical implants  
The present invention is directed to a process for synthesizing hydroxylated plasma-polymerized films, as well as the hydroxylated plasma-polymerized films produced by the process of the invention....
5096054 Electrochemical method for the removal of nitrogen oxides and sulfur oxides from flue gas and other sources  
A method for removing NOX from gases is provided. A gas comprising NOX and/or SO2 is flowed behind a gas permeable anode. Air is simultaneously flowed behind the gas permeable cathode, and the...
5085783 Acoustically driven particle separation method and apparatus  
A method for separating particles from a flowing fluid suspension comprises the steps of providing an elongated chamber having closed first and second ends, flowing into the elongated chamber a...
5082980 Process and apparatus for synthesizing oxygen-15 labelled butanol for positron emission tomography  
The present invention is directed to a process and apparatus for synthetically producing 15 O-labeled butanol for position emission tomography. A procedure and apparatus have been developed for the...
5079535 Strain gauge and method of making and using the same  
A strain gauge primarily designed for dynamic measurements and requiring very little force to produce a change in length. The strain gauge is alternately concave and convex in shape, such as a...
4989617 Intramuscular electrode for neuromuscular stimulation system  
A helix (10) is defined by two lengths of multistrand wire (14) each surrounded by flexible, biocompatible insulation (18). A silicon elastic sheath (30) surrounds the helix and extends to a...
4973111 Parametric image reconstruction using a high-resolution, high signal-to-noise technique  
An imaging apparatus and method which provides for reconstruction of images from sampled data with improved resolution, improved signal-to-noise, optimal edge detection, and pattern recognition....
4900553 Method of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes  
The present invention relates to "activated" immature astrocytes and methods of utilizing the activated immature astrocytes to reduce secondary necrosis and scar formation in central nervous system...
4873651 Method and apparatus for reconstructing three-dimensional surfaces from two-dimensional images  
A method and apparatus for reconstructing the surface, i.e the third dimension, of a three-dimensional object from two-dimemsional information includes projecting radiant energy, such as light,...
4824985 Novel route to Ca8 Si4 O12 Cl8, alkoxycyclotetrasiloxanes, aryloxycyclotetrasiloxanes, alkylcyclotetrasiloxanes and arylcyclotetrasiloxanes from wollastonite (Ca SiO3)  
The present invention relates to a process for the preparation of alkoxy, aryloxy, alkyl, and aryl cyclotetrasiloxanes from a metal silicate halide salt, Ca8 Si4 O12 Cl8.
4777234 Silicon carbide precursors  
The present application relates to novel silicon based preceramic polymers useful in the production of silicon carbide reinforcement fibers, and to the novel synthesis procedures by which such...
4655880 Apparatus and method for sensing species, substances and substrates using oxidase  
A sensor apparatus is disclosed for sensing substances, species, substrates, etc. using oxidase. The apparatus includes a pair of potentiostat operating electrode systems. In one embodiment each...
4649936 Asymmetric single electrode cuff for generation of unidirectionally propagating action potentials for collision blocking  
A single electrode, asymmetric electrode cuff (B) is disposed around a nerve trunk (A). A signal generator (C) is connected between a cathode (20) disposed asymmetrically in the electrode cuff and...
4637397 Triphasic wave defibrillation  
Method and apparatus for stimulation of cells in arrhythmic myocardial tissues includes depolarizing the cells by application of a first electrical pulse or shock followed by a second electrical...
4628942 Asymmetric shielded two electrode cuff  
A nerve trunk (A) has an annular electrode cuff (B) positioned therearound for imposing electrical signals on to the nerve trunk for the purpose of generating unidirectionally propagated action...
4624761 Polymeric material composed of sheets of polydiacetylene and polyacetylene chains  
An undoped semiconducting polymeric material is provided which is composed of a plurality of parallel sheets of regular two dimensional networks of polydiacetylene and polyacetylene chains...
4608985 Antidromic pulse generating wave form for collision blocking  
An electrode cuff (B) including a dielectric sleeve (10) and an annular cathode electrode (20) is disposed around a nerve trunk (A). An anode electrode (22) is disposed in body fluids in electrical...
4602624 Implantable cuff, method of manufacture, and method of installation  
A self-curling sheet (A) of non-conductive material is biased to curl into a tight spiral. A cut out (22) is removed from one corner of the sheet such that, when the sheet spirals, a passage (28)...
4571292 Apparatus for electrochemical measurements  
A sensor for an electrochemically active species, such as oxygen, uses more than two electrodes, namely, at least a working electrode, counter electrode and reference electrode. The sensor...
4569044 Distributed data communication system  
A passive arbitration system is employed for distributed, asynchronous, collision-free packet communication access scheduling along a high speed bus medium (1). First and second monitor end...
4519401 Pressure telemetry implant  
An implantable intracranial pressure (ICP) telemetry transmitter. Data transmission is accomplished by means of a radio frequency (RF) link coupled to a silicon piezoresistive pressure transducer....
4459856 CMOS Bridge for capacitive pressure transducers  
A fixed reference capacitance (10) and a variable, pressure sensitive capacitance (12) are defined by a common conductive layer (14), and a common dielectric layer (16). A peripheral conductive...
4249527 Continuous positive airway pressure administrating apparatus  
An apparatus for delivering continuous positive airway pressure to a patient (e.g., an infant) includes a cradle assembly for firmly and adjustably supporting the head of a patient to whom...
4228804 Diagnostic ultrasonography utilizing frequency spectrum analysis presented in terms of B-scan color patterns or X-Y graph displays  
Ultrasonographic means and method for visualizing the internal structure and composition of an in vivo soft tissue specimen as a function of its effect on the frequency spectrum of an applied...
4168316 Immunosuppressive-1-(thiocarbamoyl)-2-imidazolidinone  
By isolation and purification from the urine of patients treated with niridazole there is obtained substantially pure 1-(thiocarbamoyl)-2-imidazolidinone which exhibits marked immunosuppressive...
4162850 Field test for Schistosoma eggs  
Eggs of Schistosoma species in urine are reliably counted in a simple field test involving passing a urine sample of 10 ml or less through a thin transparent microporous membrane having pores of...
4023562 Miniature pressure transducer for medical use and assembly method  
A fluidtight, hermetically sealed, miniature transducer adapted to be inserted into the human body and useful for directly monitoring internal fluid or pneumatic pressures within the human body is...
4019727 Head support and restraining apparatus  
An apparatus for supporting and restraining the head of a patient (typically an infant) during medical treatment, for example, during the delivery of continuous positive airway pressure to a...
4011861 Implantable electric terminal for organic tissue  
A non-reacting implantable electric terminal for organic tissue, which is porous and intermeshes with the tissue including blood capillaries without the formation of a fibrous tissue encapsulation...
3996560 Sequencing unit  
An automatic sequencing circuit is disclosed which recognizes a particular coded input signal, initiates a process or data operation, and provides a coded output indicative of the operation...
3981983 Rapid, radiochemical-ligand binding assay for methotrexate  
A radiochemical ligand binding assay for methotrexate is provided. A binder factor comprising a partially purified dihydrofolic acid reductase preparation is employed. The binder factor is...
3972991 Radioisotopic assay and binder therefor  
There is provided a rapid and less costly radioisotopic assay for measuring the concentration of folate in blood serum. This procedure utilizes 3 H-pteroylmonoglutamate, unlabeled...
3952572 Beam bender  
A method and apparatus for bending beams by which a beam is subjected to pure moment bending in a critically oriented plane to avoid twist and to maintain single plane bending in a beam of...
3814470 IMPACT ABSORBER  
A mechanical energy storage device is disclosed in which a column is elastically buckled to develop a constant force over an extended axial deflection of the column end. The constant deflection...
3790252 LIGHT CONTROLLED LIGHT BEAM DEFLECTOR  
Deflection of a light beam is achieved by changing in a spatially non-homogeneous manner the refractive index of an interaction medium through which a controlled light beam and a controlling light...
3784820 TOMOGRAPHIC SCANNING PROCESS  
A radioisotope device having a collimator delimits radiation from a source. A scintillation crystal having a rectangular cross-section and a generally elongated shape receives radiation after it...
3777148 COLLIMATOR  
A collimator having a front and rear and a longitudinal axis passing from the front to the rear. Spaced septa between the front and the rear defining openings and including a plurality of...
3718868 I INVERTED LAMB DIP STABILIZED He-Ne LASER  
An extremely accurately resettable He-Ne laser including a gaseous I2 129 absorption cell in the laser cavity, and a method of stabilizing a He-Ne laser on an Inverted Lamb Dip of I2 129. The laser...
3688113 TOMOGRAPHIC RADIATION SENSITIVE DEVICE  
A radioisotope device having a collimator delimits radiation from a source. A scintillation crystal having a rectangular cross-section and a generally elongated shape receives radiation after it...
3661526 PROCESS FOR THE CATALYTIC GROWTH OF METASTABLE CRYSTALS FROM THE VAPOR PHASE  
There is provided a process for growing metastable crystals, e.g., diamonds, from seed crystals at sub-atmospheric pressures and temperatures in the range of from 800°-1,700° C. The process is c...
3630679 DIAMOND GROWTH PROCESS  
There is provided an improved process for the growth of diamonds from seed crystal with a gaseous monocarbon atom compound which is characterized by extremely low pressures not in excess of 1×10-2 ...
3630678 DIAMOND GROWTH PROCESS  
There is provided an improved process for the growth of diamonds on seed crystals with a gaseous polycarbon atom compound which is characterized by extremely low pressures not in excess of 1×10-2 ...