Patents and Patent Applications from California Institute of Technology


Match Document Document Title
9791372 Multiplexing and quantification in PCR with reduced hardware and requirements  
Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and...
9791321 340 GHz multipixel transceiver  
A multi-pixel terahertz transceiver is constructed using a stack of semiconductor layers that communicate using vias defined within the semiconductor layers. By using a stack of semiconductor...
9791032 Method for manufacturing bulk metallic glass-based strain wave gear components  
Systems and methods in accordance with embodiments of the invention implement bulk metallic glass-based strain wave gears and strain wave gear components. In one embodiment, a method of...
US20170292958 METHODS FOR PROTEOMIC PROFILING USING NON-NATURAL AMINO ACIDS  
The invention provides methods, reagents and systems for incorporating non-natural amino acids into proteins, preferably in vivo, using the endogenous protein synthesis machinery of an organism....
9783877 Systems and methods for implementing bulk metallic glass-based macroscale compliant mechanisms  
Systems and methods in accordance with embodiments of the invention implement bulk metallic glass-based macroscale compliant mechanisms. In one embodiment, a bulk metallic glass-based macroscale...
9783784 Methods for establishing and improving the survival of a population of pancreatic progenitor or stem cells  
In some embodiments, methods for improving the survival of pancreatic β-cell progenitors in culture are provided. Such methods may include contacting a population of pancreatic progenitor cells...
9783594 Human immunodeficiency virus neutralizing antibodies and methods of use thereof  
The invention provides broadly neutralizing antibodies directed to epitopes of Human Immunodeficiency Virus, or HIV. The invention further provides compositions containing HIV antibodies used for...
9782759 Methods for producing crystalline microporous solids with IWV topology and compositions derived from the same  
This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly...
US20170288787 REDUCTION OF UNMODULATED AMBIENT BLOCKERS IN REFLECTED DATA LINKS THROUGH MANIPULATION OR REPLICATION OF THE TRANSMITTING SIGNAL SOURCE  
Communication between a wireless base-station and a microwave reflector link are enhanced by feeding back a portion of the transmitter signal, adjusted for phase and amplitude, to cancel ambient...
US20170288316 LOW-PROFILE AND HIGH-GAIN MODULATED METASURFACE ANTENNAS FROM GIGAHERTZ TO TERAHERTZ RANGE FREQUENCIES  
A modulated MTS antenna including a metasurface fabricated from metallized cylinders on a ground plane. The antenna structure can be designed to operate in the Gigahertz or Terahertz frequency...
US20170287981 IMAGE SENSOR INCLUDING NANOSTRUCTURE COLOR FILTER  
An image sensor includes a first light sensor layer including light sensing cells configured to sense first light of an incident light and generate electrical signals based on the sensed first...
US20170287151 STRUCTURED LIGHT GENERATOR AND OBJECT RECOGNITION APPARATUS INCLUDING THE SAME  
A structured light generator includes a light source configured to emit light, and a first meta optical device including a first metasurface including nanostructures having sub-wavelength...
US20170284380 HALL EFFECT THRUSTER ELECTRICAL CONFIGURATION  
A Hall thruster is configured to reduce or eliminate pole erosion by electrically tying the cathode to the thruster chassis body. The electrical connection controls the ion energy hence reducing...
US20170283763 METHODS AND SYSTEM FOR INTERFERING WITH VIABILITY OF BACTERIA AND RELATED COMPOUNDS AND COMPOSITIONS  
Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.
9781842 Long-term packaging for the protection of implant electronics  
The present invention provides a micropackaged device comprising: a substrate for securing a device; a corrosion barrier affixed to said substrate; optionally at least one feedthrough disposed in...
9778234 Generation and analysis of chemical compound libraries  
Various samples are generated on a substrate. The samples each includes or consists of one or more analytes. In some instances, the samples are generated through the use of gels or through vapor...
9778155 Methods for phenotyping of intact whole tissues  
In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and...
9778154 Methods for phenotyping of intact whole tissues  
In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and...
9777359 Bulk ferromagnetic glasses free of non-ferrous transition metals  
Ferrous metal alloys including Fe, Co and optionally Ni with metalloids Si, B and P are provided that are substantially close to the peak in glass forming ability and have a combination of both...
9776242 Multiphoton induced direct aggregate scribing  
The present disclosure is directed to processes comprising irradiating an aggregate of chemically bonded or otherwise associated nanoparticles with a light source capable of providing multiphoton...
US20170275597 PHENAZINE DEGRADING AGENTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR INTERFERING WITH VIABILITY OF BACTERIA  
Provided herein are phenazine degrading agents, methods and systems for interfering with viability of bacteria and related antimicrobial and compositions.
US20170275399 ANION-COORDINATING POLYMER ELECTROLYTES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Anion-coordinating polymers comprising one or more anion-coordinating unit of Formula (I), optionally in combination with one or more cation-coordinating unit of Formula (II) and/or a linking unit...
US20170273551 FOURIER PTYCHOGRAPHIC RETINAL IMAGING METHODS AND SYSTEMS  
Certain embodiments pertain to Fourier ptychographic retinal imaging methods and systems that focus on a retina of an eye to acquire a sequence of raw retinal images, construct a full-resolution,...
9773715 Multi-layer packaging scheme for implant electronics  
The present invention provides a micropackaged device comprising: a substrate for securing a device with a corrosion barrier affixed to the substrate, wherein the corrosion barrier comprises a...
9773160 Using relevance feedback in face recognition  
Images are searched to locate faces that are the same as a query face. Images that include a face that is the same as the query face may be presented to a user as search result images. Images also...
9772227 Laser spiderweb sensor used with portable handheld devices  
A portable spectrometer, including a smart phone case storing a portable spectrometer, wherein the portable spectrometer includes a cavity; a source for emitting electromagnetic radiation that is...
9771592 Methods and compositions for treating or preventing pruritis  
The invention features therapeutic compositions comprising agents useful for the treatment or prevention of pruritis, and methods useful for identifying such agents.
9770461 Tailored glycopolymers as anticoagulant heparin mimetics  
The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive...
US20170270282 HIGH-RESOLUTION MASS SPECTROMETER AND METHODS FOR DETERMINING THE ISOTOPIC ANATOMY OF ORGANIC AND VOLATILE MOLECULES  
A mass spectrometer including an entrance slit, an energy filter, a momentum filter and a detector array, the entrance slit, energy filter and momentum filter being configured to provide molecular...
US20170266215 REDOX-ACTIVE COMPOUNDS AND RELATED COMPOUNDS, COMPOSITIONS, METHODS AND SYSTEMS  
Compounds able to affect production and/or activity of a redox active compound, which include candidate therapeutic compounds and candidate compounds for enhancing power output of a microbial fuel...
9768873 Amplification-free electro-optical oscillator  
An electro-optical oscillator includes, in part, a modulator, a signal splitter, N photodiodes with N being an integer greater than one, a signal combiner, and a filter. The modulator modulates an...
9766593 Mercury trapped ion frequency standard for ultra-stable reference applications  
An atomic clock including an ion trap assembly, a C-field coil positioned for generating a first magnetic field in the interrogation region of the ion trap assembly, a compensation coil positioned...
9766245 Method of detecting cancer based on glycan biomarkers  
The present invention provides a method for labeling or detecting a protein with certain glycosyl groups. The methods are particularly useful for detecting cancer cells comprising the detected...
9764995 Silylation of aromatic heterocycles by disilanes using potassium alkoxide catalysts  
The present invention describes chemical systems and methods for silylating heteroaromatic organic substrates using at least alkoxide base, preferably a potassium alkoxide base and at least one...
9763825 Implantable oxygen generator and transporter  
An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule...
9763570 Optical coherence tomography (OCT) system with phase-sensitive B-scan registration  
This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system having a configuration that uses a phase sensitive B-scan...
9763569 Optical coherence tomography (OCT) system with improved motion contrast  
This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to an OCT system with improved motion contrast. This disclosure particularly...
US20170263796 Encapsulated Solar Cells that Incorporate Structures that Totally Internally Reflect Light Away from Front Contacts and Related Manufacturing Methods  
Solar cells in accordance with a number of embodiments of the invention are encapsulated by a material that can render the front contacts of the solar cells effectively invisible at certain angles...
US20170263363 METHOD AND APPARATUS FOR PARTICLE ACTUATION IN A SPACE  
A device is dynamically programmable to generate at least a first magnetic field during a first time interval, and at least a second magnetic field during a second time interval thereby causing...
US20170260172 COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS  
This disclosure provides methods for intermolecular enantioselective C-acylation of lactams with quaternary stereogenic centers by applying a chiral Ni catalyst. The methods comprise treating a...
US20170259428 WEARABLE ELECTROMYOGRAPHY SENSOR ARRAY USING CONDUCTIVE CLOTH ELECTRODES FOR HUMAN-ROBOT INTERACTIONS  
A sleeve worn on an arm allows detection of gestures by an array of sensors. Electromyography, inertial, and magnetic field sensors provide data that is processed to categorize gestures and...
US20170258343 INTRINSIC FREQUENCY HEMODYNAMIC WAVEFORM ANALYSIS  
Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic...
9757729 Microfluidic device  
Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device...
US20170252729 GERMANOSILICATE COMPOSITIONS AND METHODS OF PREPARING THE SAME  
The present disclosure is directed to novel germanosilicate compositions and methods of producing the same. In particular, this disclosure describes an array of transformations originating from...
US20170252058 PLACID WIRE MECHANISM OF PENETRATING BLOCKINGS AND OCCLUSIONS IN ARTERIES  
An arterial blockage percussive drill having a guiding sleeve, a drilling wire slidably coupled to the guiding sleeve and a percussive actuator coupled to the drilling wire to longitudinally...
9754371 Multi modality brain mapping system (MBMS) using artificial intelligence and pattern recognition  
A Multimodality Brain Mapping System (MBMS), comprising one or more scopes (e.g., microscopes or endoscopes) coupled to one or more processors, wherein the one or more processors obtain training...
US20170250048 Nanoscale Field-Emission Device and Method of Fabrication  
Nanoscale field-emission devices are presented, wherein the devices include at least a pair of electrodes separated by a gap through which field emission of electrons from one electrode to the...
US20170249420 METHODS AND SYSTEMS FOR PREDICTING MEMBRANE PROTEIN EXPRESSION BASED ON SEQUENCE-LEVEL INFORMATION  
Membrane protein expression can be predicted using statistical frameworks to provide an enhanced subset of sequences, out of an initial larger set of potentially expressing sequences, by using...
US20170247725 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES  
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the...
US20170246961 Adaptive Charging Network using Adaptive Charging Stations for Electric Vehicles  
Adaptive charging networks in accordance with embodiments of the invention enable the optimization of electric design of charging networks for electric vehicles. One embodiment includes an...