Patents and Patent Applications from California Institute of Technology


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US20180052110 MULTIPLEXING AND QUANTIFICATION IN PCR WITH REDUCED HARDWARE AND REQUIREMENTS  
Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and...
US20180049716 ENHANCED STETHOSCOPE DEVICES AND METHODS  
An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic...
9900096 Optically assisted electrical filtering and processing  
An electro-optical circuit, includes in part, a modulator, a signal splitter, N signal paths each having one or more signal processing components, N photo-diodes and a signal combiner. The...
9898701 Systems and methods for the determining annotator performance in the distributed annotation of source data  
Systems and methods for determining annotator performance in the distributed annotation of source data in accordance embodiments of the invention are disclosed. In one embodiment of the invention,...
9897587 Second harmonic imaging nanoprobes and techniques for use thereof  
Second harmonic nanoprobes for imaging biological samples and a method of using such probes to monitor the dynamics of biological process using a field resonance enhanced second harmonic (FRESH)...
9896700 Engineered recombinant enzymes for methane oxidation  
Provided herein are soluble engineered polypeptides for oxidizing hydrocarbons, and methods of use, manufacture, and design thereof. In particular, soluble, polypeptides capable of oxidizing...
9895467 Light adjustable intraocular lenses using upconverting nanoparticles and near infrared (NIR) light  
This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In...
US20180048232 DIGITAL MULTIPHASE HYSTERETIC POINT-OF-LOAD DC/DC CONVERTER  
An autozeroed comparator controls a frequency fsw of the input voltage inputted to a DC/DC converter. A digital frequency synchronization circuit is connected to the autozeroed comparator so as to...
US20180044804 HYDROCARBON OXIDATION BY WATER OXIDATION ELECTROCATALYSTS IN NON-AQUEOUS SOLVENTS  
Provided herein are processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product; said process comprising: contacting a water oxidation electrocatalyst...
9892812 Fourier ptychographic x-ray imaging systems, devices, and methods  
Methods, systems, and devices of Fourier ptychographic X-ray imaging by capturing a plurality of variably-illuminated, low-resolution intensity X-ray images of a specimen and computationally...
9891382 Optomechanical device with mechanical elements and optical filters for actuating and/or detecting the movement of the elements  
An optomechanical device with mechanical elements and optical filters for actuating and/or detecting movement of the elements, including a support, and on the support: an array of mechanical...
9891355 Flat retroreflectors  
A retroreflector device is described, which includes a lens component operable for focusing radiation, which is incident thereto at an angle of incidence. The retroreflector also includes a mirror...
9890239 Functionalized linear and cyclic polyolefins  
This invention relates to methods and compositions for preparing linear and cyclic polyolefins. More particularly, the invention relates to methods and compositions for preparing functionalized...
9890207 Highly active agonistic CD4 binding site anti-HIV antibodies (HAADS) comprising modified CDRH2 regions that improve contact with GP120  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid...
US20180038922 GAS-FILLED STRUCTURES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS FOR MAGNETIC RESONANCE IMAGING  
Gas vesicle protein structures and related compositions, methods, and systems for singleplexed and/or multiplexed magnetic resonance imaging of a target site alone or in combination with...
9884075 Domain-swap T cell receptors  
Disclosed herein are genetically engineered T cell receptors, and methods, vectors, and genetically engineered T cells related to genetically engineered T cell receptors.
US20180031330 Multi-Phase Thermal Control Apparatus, Evaporators and Methods of Manufacture Thereof  
Multi-phase thermal control systems, evaporators, variable porous wick elements, heat transfer structures, and methods for their production are provided. Two-phase evaporators for use in such...
US20180030551 CHROMOPHORE-BASED CHARACTERIZATION AND DETECTION METHODS  
This disclosure provides methods, compositions and kits for the detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, compositions, and kits for...
US20180030501 GENETICALLY ENGINEERED GAS VESICLE GENE CLUSTERS, GENETIC CIRCUITS, VECTORS, PROKARYOTIC CELLS, COMPOSITIONS, METHODS AND SYSTEMS FOR CONTRAST-ENHANCED IMAGING  
Hybrid gas vesicle gene cluster (GVGC) configured for expression in a prokaryotic host are described comprising gas vesicle assembly (GVA) genes native to a GVA prokaryotic species and capable of...
US20180030207 LINEAR CYCLODEXTRIN COPOLYMERS  
Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described....
US20180029021 METHODS TO PRODUCE MOLECULAR SIEVES WITH LTA TOPOLOGY AND COMPOSITIONS DERIVED THEREFROM  
The present disclosure is directed to processing for preparing crystalline pure-silica and heteroatom-substituted LTA frameworks in fluoride media using a simple organic structure-directing agent...
US20180028693 GAS-FILLED STRUCTURES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS TO IMAGE A TARGET SITE  
Gas vesicles, protein variants and related compositions methods and systems for singleplexed and/or multiplexed ultrasound imaging of a target site in which a gas vesicle provides contrast for the...
9879068 Antibodies targeting HIV escape mutants  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for...
9878312 Methods to produce zeolites with the GME topology and compositions derived therefrom  
The present disclosure is directed to producing zeolite structures with GME topologies using organic structure directing agents (OSDAs) comprising a piperidinium cation, and the compositions and...
US20180026185 FAR-INFRARED DETECTION USING WEYL SEMIMETALS  
The generation of photocurrent in an ideal two-dimensional Dirac spectrum is symmetry forbidden. In sharp contrast, a three-dimensional Weyl semimetal can generically support significant...
US20180020955 INTRINSIC FREQUENCY ANALYSIS FOR LEFT VENTRICLE EJECTION FRACTION OR STROKE VOLUME DETERMINATION  
Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate...
9874202 Metallic wall hall thrusters  
A Hall thruster apparatus having walls constructed from a conductive material, such as graphite, and having magnetic shielding of the walls from the ionized plasma has been demonstrated to operate...
9873113 Methods for producing crystalline microporous solids with a new CIT-7 topology and compositions derived from the same  
This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly...
9873109 Catalysts for thermochemical fuel production and method of producing fuel using thermochemical fuel production  
To provide a catalyst, which is formed from a perovskite oxide, for thermochemical fuel production, and a method of producing fuel using thermochemical fuel production that is capable of allowing...
US20180018713 DELAY-TOLERANT INFORMATION-CENTRIC NETWORKING (DTICN)  
A method and system provide the ability to distribute content on a network. A network system of nodes is established. Each node hosts a repository daemon (RD). A data source node receives a bundle...
US20180016533 SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE  
A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one...
US20180015224 Dampers and Methods for Performing Measurements in an Autoinjector  
Systems and methods for measuring and damping forces within autoinjectors in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an injection system...
9870834 Error characterization and mitigation for 16nm MLC NAND flash memory under total ionizing dose effect  
A data device includes a memory having a plurality of memory cells configured to store data values in accordance with a predetermined rank modulation scheme that is optional and a memory...
9870457 HERMA—heartbeat microwave authentication  
Systems and methods for identifying and/or authenticating individuals utilizing microwave sensing modules are disclosed. A HEaRtbeat Microwave Authentication (HERMA) system can enable the active...
9868754 Utility of nematode small molecules  
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating...
9868150 Systems and methods for fabricating structures including metallic glass-based materials using low pressure casting  
Systems and methods to fabricate objects including metallic glass-based materials using low-pressure casting techniques are described. In one embodiment, a method of fabricating an object that...
US20180010166 FRACTIONAL INITIATOR HYBRIDIZATION CHAIN REACTION  
The present disclosure relates to methods and compositions involving HCR reactions that involve initiators that are split into two or more parts. Effective HCR is dependent upon two or more of...
9864184 Embedded pupil function recovery for fourier ptychographic imaging devices  
Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods that implement an embedded pupil function recovery.
9864109 Nanoscale plasmonic field-effect modulator  
A plasmonic device having a transparent conducting oxide (TCO) waveguide and a tunable voltage applied across the TCO and a metal layer for modulating an input optical signal.
9862948 Microrna inhibition for the treatment of inflammation and myeloproliferative disorders  
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated...
9862943 Long noncoding RNAs and cell reprogramming and differentiation  
Long noncoding RNAs (lncRNAs) are identified that enhance pluripotency reprogramming of somatic cells as well as differentiation of pluripotent cells. Induced pluripotent stem (iPS) cell...
9862696 Synthetic route to anhydroryanodol, ryanodol and structural analogues  
This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogs thereof and novel compounds prepared thereby.
9862090 Surrogate: a body-dexterous mobile manipulation robot with a tracked base  
Robotics platforms in accordance with various embodiments of the invention can be utilized to implement highly dexterous robots capable of whole body motion. Robotics platforms in accordance with...
9861968 Methods for producing crystalline microporous solids with the HEU topology and compositions derived from the same  
This disclosure relates to new crystalline microporous solids (including silicate- and aluminosilicate-based solids), the compositions comprising 8 and 10 membered inorganic rings, particularly...
US20180006424 HIGH-Q OPTICAL RESONATOR WITH MONOLITHICALLY INTEGRATED WAVEGUIDE  
A ring optical resonator is formed on a substrate. An outer circumferential surface of the resonator substantially confines one or more circumferential resonant optical modes. The resonator is...
US20180005809 INTEGRATED HYBRID NEMS MASS SPECTROMETRY  
A hybrid mass spectrometer comprising: an ion source for generating ions from a sample, a first mass spectral system comprising a nanoelectromechanical mass spectral (NEMS-MS) system, a second...
9858534 Weight generation in machine learning  
Technologies are generally described for systems, devices and methods relating to a machine learning environment. In some examples, a processor may identify a training distribution of a training...
9856472 Small conditional RNAs  
The present subject matter relates to the use conditional hairpins, such as, but not limited to shRNAs. The conditional formation of these structures can allow for further events, such as gene...
9851589 Meta-structure and tunable optical device including the same  
A meta-structure and a tunable optical device including the same are provided. The meta-structure includes a plurality of metal layers spaced apart from one another, an active layer spaced apart...
US20170362648 MULTIPLEX Q-PCR ARRAYS  
This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified,...