Patents and Patent Applications from California Institute of Technology


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10078142 Sensor integrated metal dielectric filters for solar-blind silicon ultraviolet detectors  
A filter for electromagnetic radiation including one or more dielectric spacer regions and one or more reflective regions integrated on a semiconductor substrate, the semiconductor substrate...
10077475 FRET-based analytes detection and related methods and systems  
FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at...
US20180261818 SEPARATOR ENCLOSURES FOR ELECTRODES AND ELECTROCHEMICAL CELLS  
The disclosure provides electrochemical cells including a separator enclosure which encloses at least a portion of a positive or negative electrode. In an embodiment, the separator generates a...
US20180258230 CONTROL OF POLYMER ARCHITECTURES BY LIVING RING-OPENING METATHESIS COPOLYMERIZATION  
In an aspect, a method of synthesizing a graft copolymer comprises the steps of: copolymerizing a first macromonomer and a first reactive diluent; wherein said first macromonomer comprises a first...
US20180257141 Methods for Fabricating Strain Wave Gear Flexsplines Using Metal Additive Manufacturing  
Methods for the fabrication of metal strain wave gear flexsplines using a specialized metal additive manufacturing technique are provided. The method allows the entire flexspline to be metal...
US20180256922 Selective Disruption of Neoplastic Cells via Resonant Harmonic Excitation  
Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods...
10075151 High power W-band/F-band Schottky diode based frequency multipliers  
A solid state device chip including diodes (generating a higher frequency output through frequency multiplication of the input frequency) and a novel on-chip power combining design. Together with...
10075104 Plasmonic nanostructures for conversion of optical power to electrical power  
A plasmoelectric device for conversion of optical power to direct current (DC) electrical power includes a first plasmonic nanostructure having a first resonance value and a second plasmonic...
10072030 Base-catalyzed silylation of terminal alkyne C—H bonds  
The present invention is directed to a mild, efficient, and general direct C(sp)-H bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of...
US20180254547 DEPLOYABLE REFLECTARRAY ANTENNA  
A deployable reflectarray antenna stowable in a 6U CubeSat volume is deployed through tape deployers and quartz cables. The telescoping waveguide is attached to the horn with a threaded insert....
US20180254478 HIGH PERFORMANCE INORGANIC COMPLEXES FOR NEXT-GENERATION REDOX FLOW BATTERIES  
In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex...
US20180252641 Method and Apparatus for the Spectroscopic Detection of Low Concentrations of Hydrogen Sulfide Gas  
Spectroscopic apparatus and methods incorporating a gas sensor configured to detect low concentration gases, including gases that are hazardous volatiles are provided. Low concentration gases can...
US20180251903 SOLAR FUELS GENERATOR WITH PH SEPARATION  
A solar fuels generator includes an anolyte and a catholyte in contact with a separator. The separator is configured such that the pH of the anolyte and the pH of the catholyte are each held at a...
US20180251829 MULTIPLEX Q-PCR ARRAYS  
This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified,...
US20180251828 MULTIPLEX Q-PCR ARRAYS  
This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified,...
10068051 Signal encoding and decoding in multiplexed biochemical assays  
This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems,...
10067507 Controllable buoys and networked buoy systems  
Buoyant sensor networks are described, comprising floating buoys with sensors and energy harvesting capabilities. The buoys can control their buoyancy and motion, and can organize communication in...
10067031 Optical frequency measurement and control using dual optical-frequency combs  
A dual-comb optical-frequency comb generator includes a tunable comb-generating laser, a coarse-comb generator, a fine-comb generator, a second harmonic generator, a coarse-comb offset...
10066263 Nucleic acid reactions and related methods and compositions  
The present invention relates to methods of nucleic acid analyte detection by PCR. In particular, methods and kits for the detection of a plurality of nucleic acid analytes and the generation of...
US20180244967 Microabrasive Compositions Containing Oöids  
Ooids, microabrasive compositions containing ooids and methods of making microabrasive compositions containing ooids are described. Generally, ooids represent small particles, which are selectable...
US20180244521 Method for Splitting Carbon Dioxide into Molecular Oxygen and Carbon  
Apparatus and methods for facilitating an intramolecular reaction that occurs in single collisions of CO2 molecules (or their derivatives amenable to controllable acceleration, such as CO2+ ions)...
US20180243720 MULTIPLEXED SURFACE ENHANCED RAMAN SENSORS FOR EARLY DISEASE DETECTION AND IN-SITU BACTERIAL MONITORING  
Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the...
10061125 Directional optical receiver  
An optical phased array (OPA) receiver selectively detects, measures and differentiates between the amplitudes and directions of signals received from different directions. Because the OPA changes...
10059726 Base-catalyzed silylation of terminal olefinic C—H bonds  
The present invention is directed to a mild, efficient, and general direct C(sp2)-H bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting...
10059607 Electrolysis electrode  
A water purification anode has a first semiconductor contacting a second semiconductor at a heterojunction. The second semiconductor includes TiO2 and excludes bismuth and niobium. The first...
10058822 Filtration membranes and related compositions, methods and systems  
Described herein are filtration membranes and related, compositions, methods and systems and in particular filtration membranes with polymeric micro/nanoparticles embedded in a polymer matrix...
US20180239168 Micro fenestrated contact lens  
A sclera or contact lens with an image of an eye that is fenestrated, or uniformly speckled with many sub-millimeter sized transparent regions or holes, is disclosed. The micro fenestrated contact...
US20180237506 HIGHLY ACTIVE AGONISTIC CD4 BINDING SITE ANTI-HIV ANTIBODIES (HAADS) COMPRISING MODIFIED CDRH2 REGIONS THAT IMPROVE CONTACT WITH GP120  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid...
10054777 Common-mode digital holographic microscope  
A lens-less digital holographic microscope, a reflective digital holographic microscope, and a digital holographic microscope including a plurality of lenses. In one example, the digital...
10053660 Substrates for high-density cell growth and metabolite exchange  
A polymer or other substrate optimized for growing cells is described, which takes the form of a micro-thin bag with gas permeable sides. Sides of the bag can be held at a fixed distance from one...
10052081 Enhanced stethoscope devices and methods  
An enhanced stethoscope device and method for operating the enhanced stethoscope are provided. The enhanced stethoscope device generally operates by providing stethoscope sensors, ultrasonic...
US20180233964 Smart RF Lensing: Efficient, Dynamic And Mobile Wireless Power Transfer  
An RF lens includes a multitude of radiators adapted to transmit radio frequency electromagnetic EM waves whose phases are modulated so as to concentrate the radiated power in a small volume of...
US20180233963 Smart RF Lensing: Efficient, Dynamic And Mobile Wireless Power Transfer  
An RF lens includes a multitude of radiators adapted to transmit radio frequency electromagnetic EM waves whose phases are modulated so as to concentrate the radiated power in a small volume of...
US20180233650 High Temperature Superconducting Materials  
A superconducting composition of matter including overlapping first and second regions. The regions comprise unit cells of a solid, the first region comprises an electrical insulator or...
US20180230524 INTEGRATED ELECTROCHEMICAL NUCLEIC ACID BASED SENSORS AND RELATED PLATFORMS  
A sensor incorporates one or more working electrodes, a counter electrode and a reference electrode. The sensor is inserted in a needle and connected to control electronics to detect the...
US20180230491 METHOD FOR EXPRESSION OF SMALL RNA MOLECULES WITHIN A CELL  
The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA...
US20180230203 ANTIBODIES TARGETING HIV ESCAPE MUTANTS  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for...
US20180230186 SELECTIVE RECOVERY  
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
US20180229808 SYSTEMS, METHODS, AND APPARATUSES FOR REDUCING HYDRODYNAMIC FRICTIONAL DRAG  
Systems, methods and apparatuses are provided for the reduction of hydrodynamic frictional drag. These systems, methods and apparatuses can include a vessel surface having an external layer and a...
US20180229038 NEUROSTIMULATOR  
Neurostimulator devices are described. An example neurostimulator device includes a stimulation assembly connectable to a plurality of electrodes, wherein the plurality of electrodes are...
US20180229037 HIGH DENSITY EPIDURAL STIMULATION FOR FACILITATION OF LOCOMOTION, POSTURE, VOLUNTARY MOVEMENT, AND RECOVERY OF AUTONOMIC, SEXUAL, VASOMOTOR, AND COGNITIVE FUNCTION AFTER NEUROLOGICAL INJURY  
Methods comprising applying electrical stimulation to patients in conjunction with physical training are described.
10048130 Context imaging raman spectrometer  
Methods and systems for Raman spectroscopy and context imaging are disclosed. One or two lasers can be used to excite Raman scattering in a sample, while a plurality of LEDs can illuminate the...
10047146 Broadly-neutralizing anti-HIV antibodies  
The present invention relates to anti-HIV antibodies. Also disclosed are related methods and compositions. HIV causes acquired immunodeficiency syndrome (AIDS), a condition in humans characterized...
US20180226841 SMART RF LENSING: EFFICIENT, DYNAMIC AND MOBILE WIRELESS POWER TRANSFER  
An RF lens includes a multitude of radiators adapted to transmit radio frequency electromagnetic EM waves whose phases are modulated so as to concentrate the radiated power in a small volume of...
US20180225411 METHODS FOR PREDICTION OF BINDING SITE STRUCTURE IN PROTEINS AND/OR IDENTIFICATION OF LIGAND POSES  
A method for modification and/or evaluation of ligand-protein and protein-protein systems is provided. Specifically, the method involves generating a final set of ligand or protein poses based on...
US20180224587 IMAGE SENSOR INCLUDING NANOSTRUCTURE COLOR FILTER  
An image sensor includes an optical sensor layer including a plurality of light-sensitive cells configured to sense light to generate electrical signals, and a color filter array layer disposed on...
US20180222781 WATER PURIFICATION USING POROUS CARBON ELECTRODE  
A water purification electrode composed of a porous carbon material is disclosed. The electrode may be used as a flow-through cathode in an electro-peroxone process providing high H2O2 production...
10041168 Graphene structure  
A method of forming graphene includes placing a substrate in a processing chamber and introducing a cleaning gas including hydrogen and nitrogen into the processing chamber. The method also...
10041072 Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell  
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be...
10041067 Methods and compositions for rapid assembly of genetic modules  
Provided herein are methods and compositions for rapid assembly of genetic modules, as well as seamless transition from in vitro to in vivo testing of genetic constructs.