Patents and Patent Applications from California Institute of Technology


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US20120035065 Aptamer Regulated Nucleic Acids and Uses Thereof  
The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a p...
8112157 Magnetic material-containing microfabricated devices for wireless data and power transfer  
This disclosure relates to the design and fabrication of micro-electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields...
8111402 Optical sensing based on overlapping optical modes in optical resonator sensors and interferometric sensors  
Techniques and devices based on transverse magnetic (TM) and transverse electric (TE) modes in an optical resonator or interferometer to provide sensitive optical detection with insensitivity to a...
8110898 Polymer-embedded semiconductor rod arrays  
A structure consisting of well-ordered semiconductor structures embedded in a binder material which maintains the ordering and orientation of the semiconductor structures. Methods for forming such...
8110353 Engineered toehold reactions and networks  
A catalytic system and method of catalyzing reactions that uses a novel toehold exchange mechanism that allows a specified input to catalyze the release of a specified output, which in turn can...
US20120028420 METHOD FOR REUSE OF WAFERS FOR GROWTH OF VERTICALLY-ALIGNED WIRE ARRAYS  
Reusing a Si wafer for the formation of wire arrays by transferring the wire arrays to a polymer matrix, reusing a patterned oxide for several array growths, and finally polishing and reoxidizing...
US20120028324 ENGINEERED MICROORGANISMS CAPABLE OF PRODUCING TARGET COMPOUNDS UNDER ANAEROBIC CONDITIONS  
The present invention is generlly provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The...
US20120026509 ON-CHIP PHASE MICROSCOPE/BEAM PROFILER BASED ON DIFFERENTIAL INTERFERENCE CONTRAST AND/OR SURFACE PLASMON ASSISTED INTERFERENCE  
A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination...
US20120024010 ENHANCING THE OPTICAL CHARACTERISTICS OF A GEMSTONE  
Various embodiments described herein comprise a gemstone or other piece of jewelry, which incorporates one or more diffractive optical elements to enhance the fire displayed by the gemstone. In...
8108943 Method and system for near-field spectroscopy using targeted deposition of nanoparticles  
There is provided in one embodiment of the invention a method for analyzing a sample material using surface enhanced spectroscopy. The method comprises the steps of imaging the sample material with...
8107692 Fingerprinted circuits and methods of making and identifying the same  
A circuit having a fingerprint for identification of a particular instantiation of the circuit is disclosed. The circuit may include a plurality of digital circuits or gates. Each of the digital...
8107081 Micro-cavity gas and vapor sensors and detection methods  
Micro-cavity gas or vapor sensors and gas or vapor detection methods. Optical energy is introduced into a resonant micro-cavity having a deformable coating such as a polymer. The coating swells or...
8105778 Hybridization chain reaction  
The present invention relates to the use of nucleic acid probes to identify analytes in a sample. In the preferred embodiments, metastable nucleic acid monomers are provided that associate in the...
8104515 Microfabricated elastomeric valve and pump systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
8104497 Microfabricated elastomeric valve and pump systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
8100672 Autonomous electrochemical actuation of microfluidic circuits  
A microfluidic structure with an electrically controlled pressure source is shown. The pressure source is an electrolyte connected with electrodes. Dissociation of the electrolyte generates the...
US20120014221 MONOLITHIC FLEXURE PRE-STRESSED ULTRASONIC HORNS  
A monolithic ultrasonic horn where the horn, backing, and pre-stress structures are combined in a single monolithic piece is disclosed. Pre-stress is applied by external flexure structures. The...
US20120013517 INTEGRATED LENS ANTENNAS FOR MULTI-PIXEL RECEIVERS FOR PLANETARY AND ASTRONOMICAL INSTRUMENTS  
Methods and apparatus for integrating lens antennas for receivers are disclosed. A method of fabricating a lens in accordance with one or more embodiments of the present invention comprises...
8098886 Computation of intrinsic perceptual saliency in visual environments, and applications  
Detection of image salience in a visual display of an image. The image is analyzed at multiple spatial scales and over multiple feature channels to determine the likely salience of different...
8097440 Engineered microorganisms capable of producing target compounds under anaerobic conditions  
The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The...
US20120009663 Nucleic Acid Amplification Using Microfludic Devices  
The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certain devices include a rotary microfluidic channel and a plurality...
US20120006376 ELECTRICAL CONTACTS FOR SKUTTERUDITE THERMOELECTRIC MATERIALS  
A thermally stable diffusion barrier for bonding skutterudite-based materials with metal contacts is disclosed. The diffusion barrier may be employed to inhibit solid-state diffusion between the...
US20120006085 ELECTROMAGNETIC FORMING OF METALLIC GLASSES USING A CAPACITIVE DISCHARGE AND MAGNETIC FIELD  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
RE43096 Tagged extendable primers and extension products  
This invention provides a duplex comprising an oligonucleotide primer and a template, wherein the primer is coupled chemically to a chromophore or fluorophore so as to allow chain extension by a...
8095210 Prosthetic devices and methods and systems related thereto  
The present invention relates to systems and methods for controlling neural prosthetic devices and electrophysiological recording equipment, and for using the same in clinical operation. Various...
8094987 Silica-on-silicon waveguides and related fabrication methods  
True time delay silica waveguides and related fabrication methods are disclosed. Also disclosed are true time delay silica waveguides comprising wedged silica structures.
8094965 Image processor  
A system and method for making an image processor. A system for processing an image may include a target image processing element, a distorted image calculating element coupled to the target image...
8094384 Camera, handlens, and microscope optical system for imaging and coupled optical spectroscopy  
An optical system comprising two lens cells, each lens cell comprising multiple lens elements, to provide imaging over a very wide image distance and within a wide range of magnification by...
8094169 Imaging model and apparatus  
A system and method for making an imaging model and an imaging apparatus. An apparatus for image processing may include an optical element having a field of view, and image sectoring element...
8092855 Click chemistry surface functionalization for resonant micro-cavity sensors  
Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional...
8092833 Compositions containing inclusion complexes  
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
8092365 Resonant multilayered impedance pump  
A multilayered impedance pump is formed by an inner tube and an outer tube which have different mechanical characteristics. The outer tube is relatively stiff, and can be used for a structural...
US20120004562 DYNAMIC MOTION CONTRAST AND TRANSVERSE FLOW ESTIMATION USING OPTICAL COHERENCE TOMOGRAPHY  
The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon phase variance. The phase variance contrast observes the nanometer scale...
8089635 Method and system for fast three-dimensional imaging using defocusing and feature recognition  
Described is a method and system for fast three-dimensional imaging using defocusing and feature recognition is disclosed. The method comprises acts of capturing a plurality of defocused images of...
8089070 Apparatus and method of manufacture for an imager equipped with a cross-talk barrier  
An imager apparatus and associated starting material are provided. In one embodiment, an imager is provided including a silicon layer of a first conductivity type acting as a junction anode. Such...
US20110319294 STABLE, FUNCTIONAL CHIMERIC CELLOBIOHYDROLASE CLASS I ENZYMES  
The present disclosure relates to CBH I chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
US20110316110 ATOMIC LAYER DEPOSITION OF CHEMICAL PASSIVATION LAYERS AND HIGH PERFORMANCE ANTI-REFLECTION COATINGS ON BACK-ILLUMINATED DETECTORS  
A back-illuminated silicon photodetector has a layer of Al2O3 deposited on a silicon oxide surface that receives electromagnetic radiation to be detected. The Al2O3 layer has an antireflection...
US20110315636 Soluble Anion Exchangers From Hyperbranched Macromolecules  
Novel macromolecules for filtering contaminants from water and non-aqueous solutions. Molecules such as polyethyleneimine (PEI) may be functionalized, cross-linked, and/or quaternized to improve...
8086943 Serial turbo trellis coded modulation using a serially concatenated coder  
Serial concatenated trellis coded modulation (SCTCM) includes an outer coder, an interleaver, a recursive inner coder and a mapping element. The outer coder receives data to be coded and produces...
8085342 Highly miniaturized, battery operated, digital wireless camera using programmable single chip active pixel sensor (APS) digital camera chip  
A miniaturized camera which is programmable and provides low power consumption. An active pixel image sensor used in the highly miniaturized camera provides improved imaging functionality as well...
8085109 Electrical funnel: a novel broadband signal combining method  
An electrical signal transformation device configured for emulation of physical, for example, optical, phenomena and/or a mathematical or logical process. The device employs a first plurality,...
US20110313030 PKR ACTIVATION VIA HYBRIDIZATION CHAIN REACTION  
The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease...
US20110309974 ANNIHILATION METHOD FOR GPS INTEGER AMBIGUITY WITH RESIDUAL PROBABILITY SCORING  
A method of locating a first GPS receiver relative to a second GPS receiver. The method includes the steps of: providing a first and second GPS receiver, the first and second GPS receiver spaced...
US20110309267 ITERATIVE TIME-REVERSAL ENHANCED TRANSMISSION SOLVING APPROACH  
A method, apparatus, and article of manufacture for irradiating a sample with electromagnetic (EM) radiation. A number of passes of EM radiation through a sample are formed and/or selected, wherein...
8081418 Low temperature double-layer capacitors  
Double-layer capacitors capable of operating at extremely low temperatures (e.g., as low as −75° C.) are disclosed. Electrolyte solutions combining a base solvent (e.g., acetonitrile) and a co...
8080531 Methods for modulating checkpoint activation through TopBP1  
ATR kinase is a key regulator of checkpoint responses to incompletely replicated and damaged DNA. Without this checkpoint, cells will enter mitosis prematurely, likely resulting in cell death. The...
8080468 Methods for fabricating passivated silicon nanowires and devices thus obtained  
Methods for fabricating passivated silicon nanowires and an electronic arrangement thus obtained are described. Such arrangements may comprise a metal-oxide-semiconductor (MOS) structure such that...
US20110307647 SYSTEMS AND METHODS FOR RAPID PROCESSING AND STORAGE OF DATA  
Systems and methods of building massively parallel computing systems using low power computing complexes in accordance with embodiments of the invention are disclosed. A massively parallel...
US20110306758 METHOD AND MATERIALS FOR THE COOPERATIVE HYBRIDIZATION OF OLIGONUCLEOTIDES  
A two-stranded intermediary complex and cooperative hybridization method are provided. The complex has been designed so that target oligonucleotides of independent sequence can cooperatively and...
US20110306522 MICROFLUIDIC PROTEIN CRYSTALLOGRAPHY  
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to...