Patents and Patent Applications from California Institute of Technology


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US20100228409 METHOD AND APPARATUS FOR POWERED DESCENT GUIDANCE  
A method and apparatus for landing a spacecraft having thrusters with non-convex constraints is described. The method first computes a solution to a minimum error landing problem for a convexified...
US20100227120 COMPOSITE NANOSTRUCTURE SOLID ACID FUEL CELL ELECTRODES VIA ELECTROSPRAY DEPOSITION  
The present invention provides a method of preparing a nanostructure material on a substrate. The method includes spraying an aqueous solution from a capillary to the substrate, wherein the aqueous...
7792894 Group algebra techniques for operating on matrices  
A computer system is configured to create a product matrix of data from two matrices of data through the use of a representation in a group algebra. The matrices are represented in a group algebra...
7792393 Silicon waveguide photodetector and related method  
A photodetector device, comprises an optical input, a nanoscale silicon waveguide and an electrical output. The waveguide is a high-contrast waveguide, with a refractive index contrast with the...
7791353 Ground loop locator  
Described is a ground loop locator. A readout on the ground loop locator indicates the presence of a ground loop when a ground loop exists in conductors linked by a current transformer of an...
7791019 Ambient pressure pyroelectric ion source for mass spectrometry  
A compact, low power ambient pressure pyroelectric ionization source. The source can be constructed using a z-cut lithium niobate or lithium tantalate crystal with an attached resistive heater...
7790381 Method for creating polynucleotide and polypeptide sequences  
The invention provides methods for evolving a polynucleotide toward acquisition of a desired property. Such methods entail incubating a population of parental polynucleotide variants under...
7790226 Pyrolyzed thin film carbon  
A method of making carbon thin films comprises depositing a catalyst on a substrate, depositing a hydrocarbon in contact with the catalyst and pyrolyzing the hydrocarbon. A method of controlling a...
7790118 Microfluidic devices and related methods and systems  
In a fluidic device with a storage compartment communication is allowed between the storage compartment and other portions of the device. The communication is controlled through a valve arrangement...
US20100219914 WIRING NANOSCALE SENSORS WITH NANOMECHANICAL RESONATORS  
A system, device, method, and apparatus provide the ability to wire a voltage sensitive device to a nanoelectromechanical system (NEMS) resonator. A voltage sensitive device is configured to detect...
7787165 High density, high bandwidth multilevel holographic memory  
A holographic memory system and apparatus, and a method provide the ability to store multibit holograms in a photorefractive crystal. A single laser diode is configured to emit a collimated laser...
7786421 Solid-state curved focal plane arrays  
The present invention relates to curved focal plane arrays. More specifically, the present invention relates to a system and method for making solid-state curved focal plane arrays from standard...
7786298 Compounds and methods for nucleic acid mismatch detection  
In accordance with the present invention there are provided sterically demanding intercalators. These compounds are useful for detection of a base-pair mismatch, such as by measuring fluorescence...
US20100216282 LOW COST BONDING TECHNIQUE FOR INTEGRATED CIRCUIT CHIPS AND PDMS STRUCTURES  
Methods of bonding a structure fabricated in polydimethylsiloxane (PDMS) and an integrated circuit chip. The procedures for bonding include providing a substrate, affixing the integrated circuit to...
7782758 Efficient loss recovery architecture for loss-decoupled TCP  
The invention provides a method and apparatus for decoupling loss recovery from congestion and window control. The system provides improved performance in high loss environments such as wireless...
7781217 Biological and chemical microcavity resonant sensors and methods of detecting molecules  
Resonant sensors and methods of detecting specific molecules with enhanced sensitivity. Optical energy is introduced into a microcavity, such as a silica toroid-shaped microcavity. The microcavity...
7781102 High-capacity nanostructured germanium-containing materials and lithium alloys thereof  
Electrodes comprising an alkali metal, for example, lithium, alloyed with nanostructured materials of formula SizGe(z-1), where 0
7780724 Monolithic in situ forming valve system  
Described is a monolithic in situ forming valve system. The valve system is delivered in an unformed, collapsed configuration that lacks any functional characteristics commonly associated with a...
7777877 High efficiency coupling optics for pumping and detection of fluorescence  
The invention provides a high efficiency coupling structure for extracting illumination such as fluorescent radiation from a chemical reaction vessel such as a cuvette. The cuvette is provided with...
7774931 Method of fabricating an integrated intraocular retinal prosthesis device  
Intraocular retinal prosthesis devices and methods for fabricating the same. A prosthesis device includes a cable region that connects an electrode array region with a power and data management...
7774930 Method of manufacturing a micromachined polymer beam structure  
An integrated composite beam structure. The structure has a substrate, which includes a surface and a thickness defined underlying the surface. The substrate is composed of a first material. A...
US20100203630 IN VITRO HUMAN B LYMPHOPOIESIS CULTURE SYSTEM  
The present disclosure relates to systems, methods and compositions for the generation of antibody-producing B cells in vitro. Some embodiments are related to an in vitro system for generating...
US20100200782 Microfabricated Elastomeric Valve And Pump Systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
7773227 Optofluidic microscope device featuring a body comprising a fluid channel and having light transmissive regions  
An optofluidic microscope device is disclosed. The device includes a fluid channel having a surface and an object such as a bacterium or virus may flow through the fluid channel. Light imaging...
7773205 High-resolution three-dimensional imaging radar  
A three-dimensional imaging radar operating at high frequency e.g., 670 GHz, is disclosed. The active target illumination inherent in radar solves the problem of low signal power and narrow-band...
7772550 Electronic drive and acquisition system for mass spectrometry  
The present invention discloses an mixed signal RF drive electronics board that offers small, low power, reliable, and customizable method for driving and generating mass spectra from a mass...
US20100197522 Microfluidic Chaotic Mixing Systems And Methods  
Microfluidic nucleic acid hybridization systems are described that include a first reaction chamber to hold an analyte solution comprising nucleic acids, and a first mixing channel in fluid...
US20100196892 Methods and Systems for Molecular Fingerprinting  
This invention relates in general to a method for molecular fingerprinting. The method can be used for forensic identification (e.g. DNA fingerprinting, especially by VNTR), bacterial typing, and...
7769071 Silica sol gel micro-laser on a substrate  
Silica sol gel micro-lasers and methods of fabricating micro-lasers on a chip or a wafer. A silica sol gel micro-laser includes a silica sol gel optical micro-cavity, a substrate, and a support...
7768654 On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference  
A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination...
7768641 Spatial image modulation to improve performance of computed tomography imaging spectrometer  
Computed tomography imaging spectrometers (“CTIS”s) having patterns for imposing spatial structure are provided. The pattern may be imposed either directly on the object scene being imaged or at ...
7766055 Microfabricated elastomeric valve and pump systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
US20100187105 Microfabricated Elastomeric Valve And Pump Systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
7763211 Method and apparatus for generating large pressures on a microfluidic chip  
The present invention relates to a method and apparatus for generating pressure suitable in magnitude for powering micro-sized devices. The present invention typically comprises a gas generation...
7762719 Microscale calorimeter  
Microcalorimeters having low addendum heat capacities and attojoule/Kscale resolutions are provided. These microcalorimeters make use of very small calorimeter bodies composed of materials with...
7762664 Optomechanical and digital ocular sensor reader systems  
System, methods, and devices are described for eye self-exam. In particular, optomechanical and digital ocular sensor reader systems are provided. The optomechanical system provides a device for...
US20100184193 OVEREXPRESSION OF AMINOACYL-tRNA SYNTHETASES FOR EFFICIENT PRODUCTION OF ENGINEERED PROTEINS CONTAINING AMINO ACID ANALOGUES  
Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of...
7760970 Single photon absorption all-optical modulator in silicon  
A single-photon absorption all-optical modulator, systems employing the same, and methods of making and using the same. An illustrative example is provided based on silicon semiconductor technology...
7759643 Single electrode corona discharge electrochemical/electrospray ionization  
A single electrode electrochemical/electrospray ionization source using a corona discharge and a method of analyzing a sample using a corona discharge single electrode electrochemical/electrospray...
7758755 Water treatment by dendrimer-enhanced filtration  
Described herein are compositions and methods useful for the purification of water using dendritic macromolecules. The process involves using dendritic macromolecules (dendrimers) to bind to...
US20100179364 Process for the Production of a Hydrocarbon  
A process for the production of a hydrocarbon which comprises contacting, in a reactor, methanol and/or dimethyl ether with a catalyst comprising a metal halide, such as a zinc halide, in which the...
US20100176981 SPLIT ANALOG/DIGITAL POLYNOMIAL NONLINEAR TERM GENERATOR WITH REDUCED NUMBER OF ANALOG-TO-DIGITAL CONVERTERS  
A polynomial nonlinear term generator is configured to receive an RF signal. An analog cubic term generator generates an analog cubic term signal and an analog square term generator generates an...
US20100176841 SEU TOLERANT ARBITER  
Single Event Upset (SEU, also referred to as soft error) tolerant arbiters, bare arbiters, and filters are disclosed. An arbiter provides a filter section, and a bare arbiter, coupled to the filter...
US20100175767 Microfabricated Elastomeric Valve and Pump Systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
7755109 Bonded semiconductor substrate  
Ge/Si and other nonsilicon film heterostructures are formed by hydrogen-induced exfoliation of the Ge film which is wafer bonded to a cheaper substrate, such as Si. A thin, single-crystal layer of...
7754010 Microfabricated elastomeric valve and pump systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
US20100172195 ULTRA-LOW-POWER VARIATION-TOLERANT RADIATION-HARDENED CACHE DESIGN  
A random access memory (RAM) cell provides a control section and a storage section coupled to the storage section. The storage section includes complementary metal-oxide semiconductor (CMOS)...
US20100171954 Method and Apparatus for Analysis and Sorting of Polynucleotides Based on Size  
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.
US20100170797 DEVICE AND METHOD FOR SINGLE CELL AND BEAD CAPTURE AND MANIPULATION BY DIELECTROPHORESIS  
A rapid and robust device and method for the capture and manipulation of single cells and beads in a microfluidic environment using positive dielectrophoresis (pDEP) is provided. The capture device...
7752332 Geometric routing in wireless networks  
Routing in a wireless network of communication devices that are located within a network boundary moves network traffic from a first communication device to a second communication device. A...