Patents and Patent Applications from California Institute of Technology


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US20090053690 SURFACE CHEMISTRY AND DEPOSITION TECHNIQUES  
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte molecules are bound to surface...
US20090052597 SCALABLE RECONFIGURABLE CONCURRENT FILTER FOR WIDE-BANDWIDTH COMMUNICATION  
The invention relates to a reconfigurable continuous FIR filter. The reconfigurable continuous FIR filter includes a delay line including at least two delay elements coupled in cascade. The...
7495230 Using a polaron interaction zone as an interface to integrate a plasmon layer and a semiconductor detector  
An integrated plasmon detector includes a top layer of material adapted to generate a plasmon when excited by a beam of light incident onto a surface of the top layer, an interface layer joined to...
7494555 Microfabricated elastomeric valve and pump systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
7493144 Multi-element phased array transmitter with LO phase shifting and integrated power amplifier  
A fully integrated CMOS multi-element phased-array transmitter (transmitter) includes, in part, on-chip power amplifiers (PA), with integrated output matching. The transmitter is adapted to be...
7491642 Electrical passivation of silicon-containing surfaces using organic layers  
Electrical structures and devices may be formed and include an organic passivating layer that is chemically bonded to a silicon-containing semiconductor material to improve the electrical...
7491628 Method for patterning large scale nano-fibrous surfaces using capillography  
A method of assembling large numbers of nanoscale structures in pre-determined ways using fluids or capillary lithography to control the patterning and arrangement of the individual nanoscale...
7491170 Noninvasive methods for assessing valvular and ventricular dysfunction  
This invention provides a system and a method for monitoring a patient's Formation number (Fn) and comparing the measured Fn to the baseline data of healthy persons population or to the patient's...
7490941 Three-dimensional hologram display system  
The present invention relates to a three-dimensional (3D) hologram display system. The 3D hologram display system includes a projector device for projecting an image upon a display medium to form a...
US20090042241 MICROFLUIDIC DEVICE  
Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device...
US20090041316 VIBRATOME ASSISTED SUBSURFACE IMAGING MICROSCOPY (VIBRA-SSIM)  
An system and method provide the ability to image a biological sample. A sample is embed to a support matrix that is compatible with an aqueous nature of the sample. A vibrating tissue sectioning...
US20090038404 METALLIC THIN FILM PIEZORESISTIVE TRANSDUCTION IN MICROMECHANICAL AND NANOMECHANICAL DEVICES AND ITS APPLICATION IN SELF-SENSING SPM PROBES  
Thin metallic films are used as the piezoresistive self-sensing element in microelectromechanical and nanoelectromechanical systems. The specific application to AFM probes is demonstrated.
7489194 Common gate with resistive feed-through low noise amplifier  
A radio-frequency amplifier is provided. The radio-frequency amplifier includes a transistor having an input terminal, an output terminal, a control terminal, and a transconductance gm. A...
7488548 Direct methanol feed fuel cell and system  
Improvements to non acid methanol fuel cells include new formulations for materials. The platinum and ruthenium are more exactly mixed together. Different materials are substituted for these...
US20090035838 Microfabricated Crossflow Devices and Methods  
A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for...
US20090035836 MODULATING PH-SENSITIVE BINDING USING NON-NATURAL AMINO ACIDS  
The invention provides methods, systems and reagents for regulating pH-sensitive protein interaction by incorporating non-natural amino acids into the protein (e.g. an antibody, or its functional...
7487050 Techniques and devices for characterizing spatially non-uniform curvatures and stresses in thin-film structures on substrates with non-local effects  
Techniques and devices are described to use spatially-varying curvature information of a layered structure to determine stresses at each location with non-local contributions from other locations...
7481534 Optomechanical and digital ocular sensor reader systems  
System, methods, and devices are described for eye self-exam. In particular, optomechanical and digital ocular sensor reader systems are provided. The optomechanical system provides a device for...
US20090022445 NANOPHOTONIC DEVICES IN SILICON  
Systems and methods for manipulating light with high index contrast waveguides clad with substances having that exhibit large nonlinear electro-optic constants χ2 and χ3. Waveguides fabricated on S...
7480434 Low loss terahertz waveguides, and terahertz generation with nonlinear optical systems  
A silicon based source for radiation in the 0.5-14 Terahertz regime. This new class of devices will permit continuously tunable, milli-Watt scale, continuous-wave, room temperature operation, a...
7480319 Optical switches and logic and methods of implementation  
Optical switches and logic devices comprising microstructure-doped nanocavity lasers are described. These switches and logic devices have gain and thus can be cascaded and integrated in a network...
7479186 Systems and methods for mixing reactants  
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated...
US20090018195 MICROFLUIDIC CHEMOSTAT  
A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more...
US20090018098 TARGETING THE ABSENCE: HOMOZYGOUS DNA DELETIONS AS SIGNPOSTS FOR CANCER THERAPY  
The present application relates to methods and compositions for targeting a homozygous DNA deletion (HD) in cells. Methods, structures, vectors and compositions for activating a payload in cells...
US20090012989 System Level Applications of Adaptive Computing (SLAAC) Technology  
An API (Application Programming Interface) for an adaptive computing system (ACS) may be used to create a system for performing an application on different types of ACS platforms. The API may be...
US20090012254 HIGH METATHESIS ACTIVITY RUTHENIUM AND OSMIUM METAL CARBENE COMPLEXES  
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic...
US20090012248 HIGH METATHESIS ACTIVITY RUTHENIUM AND OSMIUM METAL CARBENE COMPLEXES  
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic...
US20090009834 OPTICAL PHASE PROCESSING IN A SCATTERING MEDIUM  
An optical phase processing system for a scattering medium. A first beam has a direction and a wavefront and the first beam is configured to enter a holographic recording medium. A scattering...
US20090001222 CONTROL OF AERODYNAMIC FORCES BY VARIABLE WETTED SURFACE MORPHOLOGY  
Systems and methods for providing dynamic control to a vehicle in a dynamic fluid. The systems and methods of the invention relate to one or more morphable surfaces that can be controlled by a...
7471831 High throughput reconfigurable data analysis system  
The present invention relates to a system and method for performing rapid and programmable analysis of data. The present invention relates to a reconfigurable detector comprising at least one array...
7471035 Internal conductively-heated cathode  
The present invention relates to an internally heated cathode. More specifically, the internally heated cathode that comprises an a cavity structure, where at least a portion of the cavity...
7470478 Direct methanol feed fuel cell and system  
Improvements to non acid methanol fuel cells include new formulations for materials. The platinum and ruthenium are more exactly mixed together. Different materials are substituted for these...
7470369 Water treatment by dendrimer enhanced filtration  
Described herein are compositions and methods useful for the purification of water using dendritic macromolecules. The process involves using dendritic macromolecules (dendrimers) to bind to...
US20080316055 Emergency Vehicle Traffic Signal Preemption System  
An emergency vehicle traffic light preemption system for preemption of traffic lights at an intersection to allow safe passage of emergency vehicles. The system includes a real-time status monitor...
7468501 Linear dynamic range enhancement in a CMOS imager  
A CMOS imager with increased linear dynamic range but without degradation in noise, responsivity, linearity, fixed-pattern noise, or photometric calibration comprises a linear calibrated dual gain...
US20080311686 Method of Forming Semiconductor Layers on Handle Substrates  
A method of making a semiconductor thin film bonded to a handle substrate includes implanting a semiconductor substrate with a light ion species while cooling the semiconductor substrate, bonding...
7466409 Method and apparatus for CMOS imagers and spectroscopy  
A miniaturized fluidic spectrometer comprises a light source, a fluidic circuit having a plurality of flow channels through which an analyte flows, and a proximity detector array for detecting...
7465567 Peroxide-driven cytochrome P450 oxygenase variants  
The invention relates to novel variants of cytochrome P450 oxygenases. These variants have an improved ability to use peroxide as an oxygen donor as compared to the corresponding wild-type enzyme....
US20080304531 Integrated broadband quantum cascade laser  
A broadband, integrated quantum cascade laser is disclosed, comprising ridge waveguide quantum cascade lasers formed by applying standard semiconductor process techniques to a monolithic structure...
US20080304207 LOW TEMPERATURE DOUBLE-LAYER CAPACITORS  
Double-layer capacitors capable of operating at extremely low temperatures (e.g., as low as −75° C.) are disclosed. Electrolyte solutions combining a base solvent (e.g., acetonitrile) and a co...
US20080304044 HIGH-RESOLUTION THREE-DIMENSIONAL IMAGING RADAR  
A three-dimensional imaging radar operating at high frequency e.g., 670 GHz, is disclosed. The active target illumination inherent in radar solves the problem of low signal power and narrow-band...
7463680 Deterministic jitter equalizer  
An equalizer for serial data communications can be configured to compensate for the effects of deterministic jitter. The equalizer can be configured to compensate a received serial data stream for...
7462463 Fusion protein microarrays and methods of use  
The present invention provides a microarray having one or more fusion proteins non-covalently attached to a solid support. Non-covalent attachment is achieved by designing a fusion protein having a...
7462449 Methods and apparatuses for analyzing polynucleotide sequences  
Methods for high speed, high throughput analysis of polynucleotide sequences, and apparatuses with which to carry out the methods are provided in the invention.
7461512 System and method for suppressing sublimation using opacified aerogel  
The present invention relates to a castable, aerogel-based, ultra-low thermal conductivity opacified insulation to suppress sublimation. More specifically, the present invention relates to an...
US20080299104 METHODS FOR DETECTING AGENTS INVOLVED IN NEURONAL APOPTOSIS AND COMPOSITIONS THEREOF  
The invention provides methods of detecting and identifying agents which moduclate the expression or activity of synGAP, a brain-specific Ras/Rap GTPase activating protein. In vivo studies using...
7459022 Microfluidic protein crystallography  
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to...
US20080294964 SERIAL CONCATENATION OF INTERLEAVED CONVOLUTIONAL CODES FORMING TURBO-LIKE CODES  
A serial concatenated coder includes an outer coder and an inner coder. The outer coder irregularly repeats bits in a data block according to a degree profile and scrambles the repeated bits. The...
US20080293928 Cytochrom P450 oxygenases  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent...
US20080289710 MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...