Patents and Patent Applications from California Institute of Technology


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US20160058843 METHODS AND SYSTEM FOR INTERFERING WITH VIABILITY OF BACTERIA AND RELATED COMPOUNDS AND COMPOSITIONS  
Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.
US20160058808 MICROBE-BASED MODULATION OF SEROTONIN BIOSYNTHESIS  
Methods and compositions that can be used to modulate serotonin level in a subject are disclosed herein. In some embodiments, the methods include adjusting the composition of gut microbiota in the...
9272051 Methods and systems for modulating hormones and related methods, agents and compositions  
Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro or in vivo from cells of...
US20160056474 DESIGN, USE AND FABRICATION OF MICROSCAFFOLDS AND NANOSCAFFOLDS  
A scaffold includes struts that intersect at nodes. In some instances, a cross section of the cores has at least one dimension less than 100 microns. The core can be a solid, liquid or a gas. In...
US20160056321 Large-Scale Space-Based Solar Power Station: Efficient Power Generation Tiles  
A space-based solar power station, a power generating satellite module and/or a method for collecting solar radiation and transmitting power generated using electrical current produced therefrom...
US20160054553 METHOD AND DEVICE TO ACHIEVE SPATIALLY CONFINED PHOTOINTERACTION AT THE FOCAL VOLUME OF A MICROSCOPE  
The invention relates to a method and a system to achieve spatially (e.g. three-dimensionally) confined photomodulation at the focal volume (50) in a ample (55) mounted in a microscope system,...
US20160051705 FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES  
Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processes using a variety of imaging techniques are provided. The...
US20160051171 METHODS AND SYSTEMS FOR NON-INVASIVE MEASUREMENT OF BLOOD GLUCOSE CONCENTRATION BY TRANSMISSION OF MILLIMETER WAVES THROUGH HUMAN SKIN  
A device is described for interrogating human skin using tight coupling between the transmitter and receiver of the millimeter waves (MMWs). Methods are provided to evaluate changes in the...
9269731 Integrated terahertz imaging systems  
A low-power 4×4-pixel THz camera with responsivity greater than 2.5 MV/W and sub-10 pW/√Hz NEP at 0.25 THz is integrated in 130 nm silicon without using either high-resistivity substrates or...
9267140 Method for producing transgenic animals  
The present invention relates to methods for producing transgenic animals using retroviral constructs engineered to carry a transgene(s) of interest.
US20160049770 SINGLE-MODE, DISTRIBUTED FEEDBACK INTERBAND CASCADE LASERS  
Single-mode, distributed feedback interband cascade lasers (ICLs) using distributed-feedback gratings (e.g., lateral Bragg gratings) and methods of fabricating such ICLs are provided. The ICLs...
US20160048672 HERMA - Heartbeat Microwave Authentication  
Systems and methods for identifying and/or authenticating individuals utilizing microwave sensing modules are disclosed. A HEaRtbeat Microwave Authentication (HERMA) system can enable the active...
US20160047988 METHODS AND SYSTEMS FOR DELAYING OPTICAL WAVES  
Coupled-resonator optical waveguides (CROW) can be used to control a speed of an optical signal. In particular, the coupling distance between the resonators can be adjusted to precisely control a...
US20160047940 SYSTEMS AND METHODS FOR ADVANCED RAPID IMAGING AND ANALYSIS FOR EARTHQUAKES  
Many embodiments provide a hybrid data processing system (HySDS) of an end-to-end geodetic imaging data system enabling near-real-time science, assessment, response, and rapid recovery. The HySDS...
US20160046934 SIGNAL ACTIVATED RNA INTERFERENCE  
The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form...
US20160046653 SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS  
The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system or method comprising or consisting essentially of a mixture of (a) at least one...
9263854 Non-linear vertical-cavity surface-emitting laser equalization  
Technologies are generally described for implementing non-linear VCSEL equalization. In some examples, a rising edge tap parameter, a falling edge tap parameter, an equalization delay and a bias...
9263612 Heterojunction wire array solar cells  
This disclosure relates to structures for the conversion of light into energy. More specifically, the disclosure describes devices for conversion of light to electricity using ordered arrays of...
9261625 Ultra high resolution gravity gradiometery technique  
A method and system provide the ability to measure relative displacement and rotation. A first light is continuously shined from a first light source that is fixed on a first entity to a first...
9261597 Real-time and post-processed orbit determination and positioning  
Novel methods and systems for the accurate and efficient processing of real-time and latent global navigation satellite systems (GNSS) data are described. Such methods and systems can perform...
US20160040199 ENZYMATIC METHODS FOR NITROGEN-ATOM TRANSFER  
The present invention provides methods for catalyzing a nitrene insertion into a C—H bond to produce a product having a new C—N bond, comprising providing a C—H containing substrate, a nitrene...
US20160040002 METHODS AND SYSTEMS FOR SYNTHESIS OF AN ULTRA HIGH MOLECULAR WEIGHT POLYMER  
A method for controlling the physical state of an ultra-high molecular weight polymer to make the ultra-high molecular weight polymer suitable for further processing, and related polymers...
9255993 Processing satellite data for slant total electron content measurements  
A method, system, and apparatus provide the ability to estimate ionospheric observables using space-borne observations. Space-borne global positioning system (GPS) data of ionospheric delay are...
9255120 Conversion of glucose to sorbose  
The present invention is directed to methods for preparing sorbose from glucose, said method comprising: (a) contacting the glucose with a silica-containing structure comprising a zeolite having a...
US20160036563 DISTRIBUTED REED-SOLOMON CODES FOR SIMPLE MULTIPLE ACCESS NETWORKS  
A computer-based distributed error correction scheme with an efficient decoding algorithm is disclosed. The efficiency of the corresponding decoding algorithm, based on standard single source...
US20160036226 Distributed Gradient Descent for Solving Optimal Power Flow in Radial Networks  
Node controllers and power distribution networks in accordance with embodiments of the invention enable distributed power control, One embodiment includes a node controller comprising a memory...
US20160036225 Dynamic Frequency Control in Power Networks  
Node controllers in power distribution networks in accordance with embodiments of the invention enable dynamic frequency control. One embodiment includes a node controller comprising a network...
US20160035093 MULTI MODALITY BRAIN MAPPING SYSTEM (MBMS) USING ARTIFICIAL INTELLIGENCE AND PATTERN RECOGNITION  
A Multimodality Brain Mapping System (MBMS), comprising one or more scopes (e.g., microscopes or endoscopes) coupled to one or more processors, wherein the one or more processors obtain training...
US20160033794 OPTICAL PHASED ARRAY USING GUIDED RESONANCE WITH BACKSIDE REFLECTORS  
Methods and systems for controlling the phase of electromagnetic waves are disclosed. A device can consist of a guided resonance grating layer, a spacer, and a reflector. A plurality of devices,...
US20160033766 DIRECTIONAL OPTICAL RECEIVER  
An optical phased array (OPA) receiver selectively detects, measures and differentiates between the amplitudes and directions of signals received from different directions. Because the OPA changes...
US20160033755 OPTICAL SHUTTER BASED ON SUB-WAVELENGTH GRATINGS ACTUATED BY MICROELECTROMECHANICAL SYSTEMS  
Methods and systems for control of electromagnetic waves are disclosed. An optical shutter includes a sub-wavelength grating. Each beam of the grating can be controlled by electrostatic or...
US20160032330 P-450-CATALYZED ENANTIOSELECTIVE CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS  
The present invention pertains to the use of engineered variants of enzyme CYP102A, also known as P450-BM3, for cyclopropanation of olefins containing electron-withdrawing groups. One exemplary...
US20160030748 HIGH DENSITY EPIDURAL STIMULATION FOR FACILITATION OF LOCOMOTION, POSTURE, VOLUNTARY MOVEMENT, AND RECOVERY OF AUTONOMIC, SEXUAL, VASOMOTOR, AND COGNITIVE FUNCTION AFTER NEUROLOGICAL INJURY  
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal...
US20160030464 IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS  
Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for...
9252731 Passive phase noise cancellation element  
A passive electro-mechanical device that reduces phase noise in oscillators, thereby improving their frequency precision. The noise reduction device can consist of a pair of coupled nonlinear...
9250453 Integrated light source independent linewidth reduction of lasers using electro-optical feedback techniques  
An integrated optical linewidth reduction system includes a phase modulator adapted to modulate the phase of an incoming optical signal in response to a feedback control signal defined by a first...
9250148 Multi-directional environmental sensors  
Systems and methods in accordance with embodiments of the invention implement multi-directional environmental sensors. In one embodiment, a multi-directional environmental sensor includes: an...
9249401 Polypeptides having cellulase activity  
The present disclosure relates to CBH II chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
9249170 Cyclic alkyl amino carbene (CAAC) ruthenium complexes as improved catalysts for ethenolysis reactions  
Described herein are compounds and methods of catalyzing ethenolysis reactions, optionally on an industrial scale. In certain embodiments, the catalysts bear cyclic alkyl amino carbene (CAAC)...
9249016 Graphene-based multi-junctions flexible solar cell  
This disclosure relates to structures for the conversion of light into energy. More specifically, the disclosure describes devices for conversion of light to electricity using photovoltaic cells...
9248013 3-Dimensional parylene scaffold cage  
Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be...
US20160025626 SILICON PHOTONIC CRYSTAL NANOBEAM CAVITY WITHOUT SURFACE CLADDING AND INTEGRATED WITH MICRO-HEATER FOR SENSING APPLICATIONS  
A silicon photonic crystal nanobeam cavity device is described, including a heater that can set a desired temperature on the cavity device in order to control its resonant wavelength. The device...
US20160024482 ALKANE OXIDATION BY MODIFIED HYDROXYLASES  
This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable...
US20160024244 Periodic Nanostructures From Self Assembled Wedge-Type Block-Copolymers  
The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing...
US20160023352 SURROGATE: A Body-Dexterous Mobile Manipulation Robot with a Tracked Base  
Robotics platforms in accordance with various embodiments of the invention can be utilized to implement highly dexterous robots capable of whole body motion. Robotics platforms in accordance with...
US20160022727 IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS  
Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for...
9247235 Method and device for high-resolution imaging which obtains camera pose using defocusing  
A method and device for high-resolution three-dimensional (3-D) imaging which obtains camera pose using defocusing is disclosed. The device comprises a lens obstructed by a mask having two sets of...
9246529 Photonic RF down-converter based on optomechanical oscillation  
An all optical radio frequency converter. The invention relates to a microtoroid optomechanical oscillator that can provide a local oscillation frequency and a mixing functionality. The...
9243277 Sensor probe for bio-sensing and chemical-sensing applications  
The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example...
9243015 Metallocorroles  
Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes....