Patents and Patent Applications from California Institute of Technology


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US20150018781 SYSTEMS, DEVICES, AND METHODS FOR TOPICAL DRUG DELIVERY TO THE EYE  
Systems, devices, and methods are provided for delivering a therapeutic substance to the eye of a subject with an automated apparatus. The apparatus can resemble a pair of eyeglasses that can...
US20150018446 ORGANOCATALYZED PHOTOREDOX MEDIATED POLYMERIZATION USING VISIBLE LIGHT  
The present invention is directed to method of forming a polymer comprising exposing a mixture comprising an organic pre-polymer, an organic photoredox catalyst, and an organic initiator to a...
US20150018291 The Utility of Nematode Small Molecules  
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating...
US20150018232 ELECTROCHEMICAL SUBSTRATE PATTERNING AND ANALYTE DETECTION ON A TWO-ELECTRODE PLATFORM  
A two-electrode detection system having target substrates including nucleic acids, proteins, and/or small molecules on specifically defined regions of a single surface. The spatial distribution of...
US20150017038 HELICALLY ACTUATED POSITIVE-DISPLACEMENT PUMP AND METHOD  
First and second structures are connected by helical fibers. The orientation between the first and second structures are changed, and by doing so, the positions of the helical fibers are...
US20150014885 SYSTEMS AND METHODS FOR ADDITIVE MANUFACTURING PROCESSES THAT STRATEGICALLY BUILDUP OBJECTS  
Systems and methods in accordance with embodiments of the invention implement additive manufacturing techniques that employ different sets of deposition characteristics and/or material formation...
8933143 On-demand photoinitiated polymerization  
Compositions and methods for adjustable lenses are provided. In some embodiments, the lenses contain a lens matrix material, a masking compound, and a prepolymer. The lens matrix material provides...
8932461 Microfluidic sieve valves  
Sieve valves for use in microfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing...
US20150011042 METHOD OF MAKING PHOTOVOLTAIC DEVICES INCORPORATING IMPROVED PNICTIDE SEMICONDUCTOR FILMS  
The present invention uses a treatment that involves an etching treatment that forms a pnictogen-rich region on the surface of a pnictide semiconductor film The region is very thin in many modes...
US20150010976 REGIO- AND ENANTIOSELECTIVE ALKANE HYDROXYLATION WITH MODIFIED CYTOCHROME P450  
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
US20150010788 Carbon Nanotubes - Graphene Hybrid Structures for Separator Free Silicon - Sulfur Batteries  
Provided herein are electrochemical systems and related methods of making and using electrochemical systems. Electrochemical systems of the invention implement novel cell geometries and composite...
US20150010578 DELIVERY OF PROTEINS USING ADENO-ASSOCIATED VIRUS (AAV) VECTORS  
Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
US20150009149 IMAGING SURROUND SYSTEM FOR TOUCH-FREE DISPLAY CONTROL  
The subject system hardware and methodology combine disparate cameras into a cohesive gesture recognition environment. To render an intended computer, gaming, display, etc. control function, two...
8929415 Photonic crystal cavities and related devices and methods  
Photonic crystal cavities and related devices and methods are described. The described cavities can be used as lasers, photovoltaic sources, and single photon sources. The cavities can be both...
8928379 Minimal power latch for single-slope ADCs  
A latch circuit that uses two interoperating latches. The latch circuit has the beneficial feature that it switches only a single time during a measurement that uses a stair step or ramp function...
8928036 High operating temperature barrier infrared detector with tailorable cutoff wavelength  
A barrier infrared detector with absorber materials having selectable cutoff wavelengths and its method of manufacture is described. A GaInAsSb absorber layer may be grown on a GaSb substrate...
8928029 Single-band and dual-band infrared detectors  
Bias-switchable dual-band infrared detectors and methods of manufacturing such detectors are provided. The infrared detectors are based on a back-to-back heterojunction diode design, where the...
8927300 Method and compositions for the detection of protein glycosylation  
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations....
8926524 System, apparatus and method for biomedical wireless pressure sensing  
An implantable polymer-based pressure sensor featuring an electrical LC-tank resonant circuit for passive wireless sensing without power consumption on the implanted site. The sensor is...
US20150005568 REMOTE ACTIVATION OF THE MIDBRAIN BY TRANSCRANIAL DIRECT CURRENT STIMULATION OF PREFRONTAL CORTEX  
A method and system of remotely stimulating the midbrain area is disclosed. Transcranial direct current stimulation is applied via a cathode attached to the right dorsolateral prefrontal cortex...
US20150004683 METHODS AND APPARATUS FOR ASSAYS OF BACTERIAL SPORES  
Described herein are methods and apparatus for assays of bacterial spores. In particular, methods and apparatus for lateral flow immunoassay for bacterial spore detection and quantification,...
US20150004668 ALKANE OXIDATION BY MODIFIED HYDROXYLASES  
This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable...
US20150004615 SMALL CONDITIONAL RNAs  
The present subject matter relates to the use conditional hairpins, such as, but not limited to shRNAs. The conditional formation of these structures can allow for further events, such as gene...
US20150004094 MOLECULAR SIEVES WITH A LINDE TYPE A TOPOLOGY AND RELATED METHODS AND SYSTEMS  
A method for preparing molecular sieves with a Linde Type A (LTA) topology structure, and molecular sieves obtained thereby are described wherein a structure directing agent comprising a...
US20150002921 POINT-WISE PHASE MATCHING FOR NONLINEAR FREQUENCY GENERATION IN DIELECTRIC RESONATORS  
An optical resonator fabricated from a uniaxial birefringent crystal, such as beta barium borate. The crystal is cut with the optical axis not perpendicular to a face of the cut crystal. In some...
8921789 Tunable compliant optical metamaterial structures  
A tunable metamaterial structure, comprises a flexible substrate capable of being strained, a metamaterial pattern on a surface of the flexible substrate, and a metal layer on the metamaterial...
8920981 Lithium ion electrolytes and lithium ion cells with good low temperature performance  
There is provided in one embodiment of the invention an electrolyte for use in a lithium ion electrochemical cell. The electrolyte comprises a mixture of an ethylene carbonate (EC), an ethyl...
US20140377742 MICROFLUIDIC DEVICE  
Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device...
US20140374631 FLOW CAGE ASSEMBLIES  
Apparatus, systems and methods for implementing flow cages and flow cage assemblies in association with high pressure fluid flows and fluid valves are provided. Flow cages and flow assemblies are...
US20140373889 TE PERFORMANCE BY BAND CONVERGENCE IN (Bi1-XSbX)2Te3  
Disclosed herein are thermoelectric materials with high performance characteristics, and methods of use thereof Among the thermoelectric materials disclosed are those of the formula...
8917444 Chip-based frequency comb generator with microwave repetition rate  
A frequency comb generator fabricated on a chip with elimination of a disadvantageous reflow process, includes an ultra-high Q disk resonator having a waveguide that is a part of a wedge structure...
8916394 Method for manufacturing a carbon nanotube field emission device with overhanging gate  
A carbon nanotube field emission device with overhanging gate fabricated by a double silicon-on-insulator process. Other embodiments are described and claimed.
8916355 Pain signaling molecules  
The invention relates generally to novel genes expressed in normal but not Neurogenin-1-deficient animals. The invention relates specifically to a novel family of G protein-coupled receptors and a...
8916208 Aluminophosphate-based materials for the treatment of wounds  
A method is provided for promoting blood clotting. The area which is bleeding is contacted with an aluminophosphate molecular sieve. The molecular sieve preferably contains a substance which...
US20140371353 ENGINEERED AGGREGATES FOR METAMATERIALS  
Materials and Methods for implementing engineered aggregates in metamaterials are provided. The engineered aggregates may be tuned to oscillate resonantly under the influence of an external force...
US20140368617 DEFOCUSING FEATURE MATCHING SYSTEM TO MEASURE CAMERA POSE WITH INTERCHANGEABLE LENS CAMERAS  
A lens and aperture device for determining 3D information. An SLR camera has a lens and aperture that allows the SLR camera to determine defocused information.
US20140367575 INTEGRATED TERAHERTZ IMAGING SYSTEMS  
A low-power 4×4-pixel THz camera with responsivity greater than 2.5 MV/W and sub-10 pW/√Hz NEP at 0.25 THz is integrated in 130 nm silicon without using either high-resistivity substrates or...
8914713 Erasure coding scheme for deadlines  
Error correction coding for streaming communication is provided. A streaming problem is modeled as a non-multicast network problem with a nested receiver structure. Each packet in the streaming...
8912892 Autonomous and controllable systems of sensors and methods of using such systems  
An autonomous and controllable system of sensors and methods for using such a system of sensors are described.
8912425 Self-tuning of carrier concentration for high thermoelectric performance  
The inventors demonstrate herein that homogeneous Ag-doped PbTe/Ag2Te composites exhibit high thermoelectric performance (˜50% over La-doped composites) associated with an inherent temperature...
8912347 Synthetic transtaganolide and basiliolide products, derivatives thereof, and synthesis methods thereof  
Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.
8912149 Glycosaminoglycan mimetics  
The present invention provides composition comprising one or more glycosaminoglycan mimetics and uses thereof. The subject glycosaminoglycan mimetics are particularly useful for treatment of...
8912011 Antibodies to sulfated carbohydrates  
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to chondroitin sulfate, particularly CS-A, CS-C and CS-E tetrasaccharides. The present...
8911603 LED-based screener for photoelectrochemical materials discovery  
An LED-based materials analysis apparatus that measures the photoelectrochemical response of materials to illumination. The apparatus uses an array of light sources such as a plurality of LEDs...
8911572 Tough iron-based bulk metallic glass alloys  
A family of iron-based, phosphor-containing bulk metallic glasses having excellent processability and toughness, methods for forming such alloys, and processes for manufacturing articles therefrom...
8911568 Ni and cu free Pd-based metallic glasses  
The invention is directed to Pd-based metallic glass alloys useful in biomedical applications having no Ni or Cu. Exemplary metallic glass alloys are represented by AaBb{(Si)100-c(D)c}d, where A...
8910727 Ultrasonic/sonic jackhammer  
The invention provides a novel jackhammer that utilizes ultrasonic and/or sonic vibrations as source of power. It is easy to operate and does not require extensive training, requiring...
US20140364631 DIELS-ALDER REACTIONS CATALYZED BY LEWIS ACID CONTAINING SOLIDS: RENEWABLE PRODUCTION OF BIO-PLASTICS  
The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and...
US20140364386 Small Molecule Compounds That Control Plant- and Insect-Pathogenic Nematodes  
The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode...
US20140362495 Systems and Methods for Implementing High-Temperature Tolerant Supercapacitors  
Systems and methods in accordance with embodiments of the invention implement high-temperature tolerant supercapacitors. In one embodiment, a high-temperature tolerant super capacitor includes a...