Patents and Patent Applications from California Institute of Technology


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9317473 Scalable room temperature quantum information processor  
A quantum information processor (QIP) may include a plurality of quantum registers, each quantum register containing at least one nuclear spin and at least one localized electronic spin. At least...
9316586 Apparatus for thermal cycling  
This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly...
9316545 Scanning measurement of Seebeck coefficient of a heated sample  
A novel scanning Seebeck coefficient measurement technique is disclosed utilizing a cold scanning thermocouple probe tip on heated bulk and thin film samples. The system measures variations in the...
9316329 Hydraulic high pressure valve controller using the in-situ pressure difference  
A hydraulic valve controller that uses an existing pressure differential as some or all of the power source for valve operation. In a high pressure environment, such as downhole in an oil or gas...
9315862 Aptamer regulated nucleic acids and uses thereof  
The invention relates to trans-acting ligand-responsive nucleic acids and uses thereof. In particular, a ligand responsive nucleic acid comprises an effector domain and an aptamer domain that is...
9315259 Morphing surfaces for the control of boundary layer transition  
A structure configured to modify its surface morphology between a smooth state and a rough state in response to an applied stress. In demonstrated examples, a soft (PDMS) substrate is produced,...
US20160105973 MICRO-FABRICATED GROUP ELECTROPLATING TECHNIQUE  
Methods, and devices produced by the methods, for electroplating a multitude of micro-scale electrodes that are electrically isolated from each other on a cable or other device is described. A...
US20160105968 BIOCOMPATIBLE RIBBON CABLE WITH NARROW FOLDED SECTION  
A biocompatible, micro-fabricated ribbon cable is described in which at least one set of conductors diverges laterally into a bypass wing that forms an aperture through the ribbon cable. The...
US20160102137 CROSSLINKED ANTI-HIV-1 COMPOSITIONS FOR POTENT AND BROAD NEUTRALIZATION  
An anti-HIV-1 spike composition includes a first anti-HIV-1 antibody Fab and a second anti-HIV-1 antibody Fab linked by a DNA or protein linker molecule to form a crosslinked homo-diFab or...
US20160101415 ORGANIC-FREE SYNTHESIS OF SMALL PORE ZEOLITE CATALYSTS  
The present invention is directed to methods of enhancing the catalytic activities of 8-MR zeolites, the methods comprising treating a precursor 8-MR zeolite that has been prepared without the use...
US20160101414 HIGHLY Z-SELECTIVE AND ENANTIOSELECTIVE RING OPENING/CROSS METATHESIS CATALYZED BY A RESOLVED STEREOGENIC-AT-RU COMPLEX  
This invention relates generally to enantiomerically enriched C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at ruthenium, to the preparation of such compounds,...
US20160100977 AUTONOMOUS TEMPERATURE CONTROL OF HEATING DEVICES FOR MEDICAL TREATMENT  
The present invention is directed to heating devices, and methods of treatment using the same, wherein the heating devices comprise (a) a polymer matrix comprising a matrix of: (i) at least one...
9313423 Deep tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light  
A device and method for performing fluorescence imaging with digitally time reversed ultrasound encoded light, using a source of ultrasound waves, a coherent light source, a digital optical phase...
9311745 Systems and methods of analysis of granular elements  
Systems and methods are described for performing mechanical analysis of particulate systems by describing particle morphology of particles within the system using Non-Uniform Rational Basis Spline...
9309580 Forming of metallic glass by rapid capacitor discharge  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
9309568 Aptamer regulated nucleic acids and uses thereof  
The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a...
9309269 Transition-metal-free silylation of aromatic compounds  
The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one...
9308525 Methods for providing bond activation catalysts and related catalysts, systems, and methods  
Described herein are catalysts for activation of an R—H bond in a R—H substrate and related catalytic matrices, compositions, methods and systems.
US20160099804 SIGNAL DIGITIZER AND CROSS-CORRELATION APPLICATION SPECIFIC INTEGRATED CIRCUIT  
According to one embodiment, a cross-correlator comprises a plurality of analog front ends (AFEs), a cross-correlation circuit and a data serializer. Each of the AFEs comprises a variable gain...
US20160097715 INTEGRATED WIDE TARGET RANGE OPTICAL COUPLING-BASED MACH-ZEHNDER SENSOR  
A sensor includes, in part, a multitude of splitters/couplers and optical couplers. One of the splitter/couplers splits an incoming optical signal into first and second optical signals. A first...
US20160097656 DECOUPLED MAGNETOQUASISTATIC NON-LINE-OF-SIGHT POSITION AND ORIENTATION SENSING FOR ARBITRARY DISTANCES  
Methods and systems for non-line-of-sight positioning are disclosed for arbitrarily short to long ranges, where positioning is achieved using a single anchor not requiring tri-/multi-lateration or...
US20160097156 CONTINUOUS TENSILE SYSTEM WITH MULTI-STAGE BRAIDING  
A continuous tensile system is disclosed. The system is braided from individual ropes that form bridle legs, riser, and extension lines in a parachute system. The continuous nature of the braided...
US20160096810 ENANTIOSELECTIVE SYNTHESIS OF DIALKYLATED N,O-HETEROCYCLES BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION  
This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation...
9303072 Method of stimulating an immune response using a pseudotyped lentivirus  
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific...
9302922 Filtration membranes and related compositions, methods and systems  
Described herein are filtration membranes and related, compositions, methods and systems and in particular filtration membranes with polymeric micro/nanoparticles embedded in a polymer matrix...
9297058 Injection molding of metallic glass by rapid capacitor discharge  
An apparatus and method of uniformly heating, softening, and thermoplastically forming magnetic metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool are...
9295375 Programmable spectral source and design tool for 3D imaging using complementary bandpass filters  
An endoscopic illumination system for illuminating a subject for stereoscopic image capture, the illumination system includes a light source which outputs multi-spectral light; first and second...
US20160088205 MULTIPLEXED FOURIER PTYCHOGRAPHY IMAGING SYSTEMS AND METHODS  
Certain embodiments pertain to Multiplexed Fourier Ptychographic imaging systems and methods. In one example, the Multiplexed Fourier Ptychographic imaging system includes an LED array configured...
US20160084707 LASER SPIDERWEB SENSOR USED WITH PORTABLE HANDHELD DEVICES  
A portable spectrometer, including a smart phone case storing a portable spectrometer, wherein the portable spectrometer includes a cavity; a source for emitting electromagnetic radiation that is...
9294077 Method and circuit for injecting a precise amount of charge onto a circuit node  
A method and circuit for injecting charge into a circuit node, comprising (a) resetting a capacitor's voltage through a first transistor; (b) after the resetting, pre-charging the capacitor...
9293887 Chip-based laser resonator device for highly coherent laser generation  
A highly-coherent chip-based laser generating system includes a disk resonator incorporating a wedge structure fabricated from a silicon dioxide layer of a chip. The disk resonator is operable to...
9293773 Electrolytes for wide operating temperature lithium-ion cells  
Provided herein are electrolytes for lithium-ion electrochemical cells, electrochemical cells employing the electrolytes, methods of making the electrochemical cells and methods of using the...
9292789 Continuous-weight neural networks  
A computer-based multi-layer artificial network named Continuous-weight neural network (CWNN) configured to receive an input feature set wherein the input feature set comprises a variable number...
9291600 Piezoresistive NEMS array network  
A sensor for detecting analytes, a method of making the sensor, and a method of using the sensor. In one embodiment, the present invention comprises at least one array comprising a plurality of...
9291536 Broadband electromechanical spectroscopy  
An apparatus, method, and material wherein the material's viscoelastic and/or fatigue life may be altered by application of a secondary tuning electromagnetic field or a selected temperature, and...
9290761 MicroRNA inhibition for the treatment of inflammation and myeloproliferative disorders  
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated...
9289757 Molecular sieves and related methods and structure directing agents  
Method for preparing molecular sieves and molecular sieves obtained thereby are described. The method includes preparing a reaction mixture, comprising a structure directing agent, at least one...
US20160079966 QUADRATURE-BASED INJECTION LOCKING OF RING OSCILLATORS  
Technologies are generally described for quadrature-based injection-locking offing oscillators. In some examples, an external signal may be injected into a ring oscillator. Phase signals may be...
US20160077261 SIMULTANEOUS POLARIZATION AND WAVEFRONT CONTROL USING A PLANAR DEVICE  
Methods and device for controlling optical scattering are disclosed. An array of 4-fold asymmetric cylinders can act as optical elements scattering electromagnetic waves, where the orientation and...
US20160076085 METHODS FOR DETECTING AND QUANTIFYING VIABLE BACTERIAL ENDO-SPORES  
Methods and systems for detecting viable bacterial endospores in a sample and related methods to quantify viable bacterial endospores in a sample.
9288915 IC-processed polymer nano-liquid chromatography system on-a-chip and method of making it  
Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The...
9287435 Method of making photovoltaic devices incorporating improved pnictide semiconductor films  
The present invention uses a treatment that involves an etching treatment that forms a pnictogen-rich region on the surface of a pnictide semiconductor film The region is very thin in many modes...
9285652 Point-wise phase matching for nonlinear frequency generation in dielectric resonators  
An optical resonator fabricated from a uniaxial birefringent crystal, such as beta barium borate. The crystal is cut with the optical axis not perpendicular to a face of the cut crystal. In some...
9285027 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Systems and methods for implementing bulk metallic glass-based strain wave gears and strain wave gear components
 
Bulk metallic glass-based strain wave gears and strain wave gear components. In one embodiment, a strain wave gear includes: a wave generator; a flexspline that itself includes a first set of gear...
9284587 Stable, functional chimeric cellobiohydrolase class I enzymes  
The present disclosure relates to CBH I chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
9284520 Instruments for biological sample preparation devices  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or...
US20160071994 METHOD OF MAKING PHOTOVOLTAIC DEVICES WITH REDUCED CONDUCTION BAND OFFSET BETWEEN PNICTIDE ABSORBER FILMS AND EMITTER FILMS  
The principles of the present invention are used to reduce the conduction band offset between chalcogenide emitter and pnictide absorber films. Alternatively stated, the present invention provides...
US20160069810 SURFACE ENHANCED RAMAN SPECTROSCOPY DETECTION OF GASES, PARTICLES AND LIQUIDS THROUGH NANOPILLAR STRUCTURES  
Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the...
US20160069686 OPTOMECHANICAL DISK VIBRATORY GYROSCOPES  
An integrated optomechanical disk vibratory gyroscope device includes a mechanical oscillator having a substantially circular structure. The substantially circular structure is supported by a...
US20160068669 BRUSH BLOCK COPOLYMER INFRARED 1-D PHOTONIC CRYSTALS USING LINEAR POLYMER ADDITIVES  
The present invention is directed to brush block copolymer compositions comprising first and second homopolymers or random copolymers whose presence provides access to photonic bandgaps in the...