Patents and Patent Applications from California Institute of Technology


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US20150152435 METHOD FOR EXPRESSION OF SMALL RNA MOLECULES WITHIN A CELL  
The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA...
9048431 Electronic devices employing aligned organic polymers  
The devices can be fabricated by a method that permits active polymer chains to be polymerized on the surface of an electrode such that the active polymer chains are aligned with one another. The...
9048097 Semiconductive micro- and nano-wire array manufacturing  
The disclosure provides methods of manufacturing semiconductive structures using stamping and VLS techniques.
9046680 Scanning illumination microscope  
A microscopy method and configuration provides the ability to achieve wide field view and high resolution simultaneously. A beam array generator generates an M×N light beam array that illuminates...
9046525 Method of determining the oligomeric state of a protein complex  
A method of counting protein subunits to determine the oligomeric state of an oligomeric protein complex includes tagging and expressing the protein subunits with a mass/charge tag and selectively...
9045579 Periodic nanostructures from self assembled wedge-type block-copolymers  
The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing...
9045343 Carbon nanotube foams with controllable mechanical properties  
Syntheses of carbon nanotubes (CNT) are disclosed. The syntheses can take place on a thermally oxidized silicon surface placed inside a furnace prior to a reaction. The setup can have many...
9044800 High aspect ratio parts of bulk metallic glass and methods of manufacturing thereof  
Bulk metallic articles having a high-aspect ratio that are formed of bulk metallic glass, that are net-shaped and that are produced under process conditions that maximize the quality and integrity...
US20150147810 ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS  
Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be...
US20150145350 ACTIVE CMOS RECOVERY UNITS FOR WIRELESS POWER TRANSMISSION  
A rectifying circuit includes, in part, first and second NMOS transistors, an impedance matching network, and an RF block circuit. The source and gate terminals of the first NMOS transistor...
US20150145091 Single-Band and Dual-Band Infrared Detectors  
Bias-switchable dual-band infrared detectors and methods of manufacturing such detectors are provided. The infrared detectors are based on a back-to-back heterojunction diode design, where the...
9042418 III-V photonic crystal microlaser bonded on silicon-on-insulator  
Novel methods and systems for miniaturized lasers are described. A photonic crystal is bonded to a silicon-on-insulator wafer. The photonic crystal includes air-holes and can include a waveguide...
9042003 Chip-based frequency comb generator with microwave repetition rate  
A frequency comb generator fabricated on a chip with elimination of a disadvantageous reflow process, includes an ultra-high Q disk resonator having a waveguide that is a part of a wedge structure...
9041938 Surface wave assisted structures and systems  
A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an...
9040495 General composition framework for ligand-controlled RNA regulatory systems  
The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom....
9039504 Games having biotechnological content  
Systems and methods for use in playing biotic games having a biologically active material as a component. Various games that provide for one or more human players to interact with biologically...
US20150142398 METHODS FOR A MULTI-SCALE DESCRIPTION OF THE ELECTRONIC STRUCTURE OF MOLECULAR SYSTEMS AND MATERIALS AND RELATED APPLICATIONS  
A method for simulating a molecular system involving partitioning the system into a plurality of subsystems at the level of one-particle basis functions and applying different mean-field levels of...
US20150141670 DIELS-ALDER REACTIONS CATALYZED BY LEWIS ACID CONTAINING SOLIDS: RENEWABLE PRODUCTION OF BIO-PLASTICS  
The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and...
US20150141640 Sulfonic Esters Of Metal Oxides And Methods Of Their Use  
The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
US20150141603 LATENT, HIGH-ACTIVITY OLEFIN METATHESIS CATALYSTS CONTAINING AN N-HETEROCYCLIC CARBENE LIGAND  
The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an N-heterocyclic carbene ligand and a chelating carbene ligand associated with a...
US20150139257 NON-LINEAR VERTICAL-CAVITY SURFACE-EMITTING LASER EQUALIZATION  
Technologies are generally described for implementing non-linear VCSEL equalization. In some examples, a rising edge tap parameter, a falling edge tap parameter, an equalization delay and a bias...
US20150137895 QUADRATURE-BASED INJECTION LOCKING OF RING OSCILLATORS  
Technologies are generally described for quadrature-based injection-locking of ring oscillators. In some examples, an external signal may be injected into a ring oscillator. Phase signals may be...
9037209 Bio-diagnostic testing system and methods  
An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle...
9034685 Methodology for forming pnictide compositions suitable for use in microelectronic devices  
The present invention provides methods for making pnictide compositions, particularly photoactive and/or semiconductive pnictides. In many embodiments, these compositions are in the form of thin...
9034577 Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell  
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be...
US20150130293 GENERATOR UNIT FOR WIRELESS POWER TRANSFER  
An RF signal generator wirelessly transferring power to a wireless device includes, in part, a multitude of generating elements generating a multitude of RF signals transmitted by a multitude of...
9031102 Methods of modulating microlasers at ultralow power levels, and systems thereof  
A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least...
9030417 Method and apparatus for preventing incorrect input in portable terminal  
According to certain embodiments, a method and apparatus for preventing incorrect input in a portable terminal includes identifying an input character string and, among previously registered...
9029524 Signal activated RNA interference  
The invention provides compositions and methods for signal activated RNA interference (saRNAi), preferably in vivo. The invention provides polynucleotides that switches between an inactive form...
9029158 Microfluidic device  
Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device...
US20150125383 CATALYSTS FOR THERMOCHEMICAL FUEL PRODUCTION AND METHOD OF PRODUCING FUEL USING THERMOCHEMICAL FUEL PRODUCTION  
To provide a catalyst, which is formed from a perovskite oxide, for thermochemical fuel production, and a method of producing fuel using thermochemical fuel production that is capable of allowing...
US20150125157 HIGH BANDWIDTH OPTICAL LINKS FOR MICRO-SATELLITE SUPPORT  
A method, systems, apparatus and device enable high bandwidth satellite communications. An onboard tracking detector, installed in a low-earth orbit satellite, detects a position of an incoming...
9026193 Intrinsic frequency hemodynamic waveform analysis  
Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic...
9024606 Low-to-medium power single chip digital controlled DC-DC regulator for point-of-load applications  
A DC-DC converter for generating a DC output voltage includes: a digitally controlled pulse width modulator (DPWM) for controlling a switching power stage to supply a varying voltage to an...
9024344 Surface passivation by quantum exclusion using multiple layers  
A semiconductor device has a multilayer doping to provide improved passivation by quantum exclusion. The multilayer doping includes at least two doped layers fabricated using MBE methods. The...
US20150118188 DIRECT PHOTOPATTERNING OF ROBUST AND DIVERSE MATERIALS  
The present invention relates to methods of metathesizing olefins using catalysts previously considered to be practically inactive. The present invention further relates to novel photosensitive...
9018684 Chemical sensing and/or measuring devices and methods  
Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in...
9016125 NEMS comprising AlSi alloy based transducer  
A nano electro-mechanical system (NEMS) formed on a substrate is provided including at least one fixed part associated with the substrate and at least one movable part in relation to the...
US20150112219 INTRINSIC FREQUENCY ANALYSIS FOR LEFT VENTRICLE EJECTION FRACTION OR STROKE VOLUME DETERMINATION  
Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate...
US20150111950 INHIBITION OF DNA2 IN FANCONI ANEMIA  
Inhibition of DNA2 in Fanconi anemia (FA) cells remedies the over-resection of DNA, thereby stabilizing the FA cells. Inhibition of DNA2 in FA cells allows for safe treatment of cancers in FA...
US20150111023 IN-SITU HEATED DEPOSITION OF PARYLENE TO ENHANCE PORE PENETRATION INTO SILICONE  
Coating porous material, such as PDMS, with parylene N, C, D, and AF-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is...
US20150110712 CRYSTALLINE MOLECULAR SIEVES AND RELATED STRUCTURE-DIRECTING AGENTS, METHODS AND SYSTEMS  
A composition and method for preparing molecular sieves having a STW framework structure are described wherein a structure directing agent comprising quaternary cation...
9012189 Modified alcohol dehydrogenases for the production of fuels and chemicals  
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
9011330 Implantable vascular system biosensor with grown capillary beds and uses thereof  
An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more...
9010935 Systems and methods for noninvasive analysis of retinal health and function  
A method for noninvasive analysis of a retina includes exposing the retina to one or more first sets of at least three illumination light signals. The at least three illumination light signals...
US20150106071 METHODS AND SYSTEMS FOR COMPARING VERTICAL AXIS TURBINE ARRAYS AND PROVIDING CONFIGURATIONS THEREOF  
A method for providing potential flow elements including a vortex to capture rotation of a turbine, a dipole to capture a blockage effect of the turbine, a sink to capture extracted energy from...
US20150105552 SYNTHESIS OF CHIRAL ENAMINONES, THEIR DERIVATIVES, AND BIOACTIVITY STUDIES THEREOF  
This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the...
US20150104371 CATALYTIC AMMONIA SYNTHESIS BY TRANSITION METAL MOLECULAR COMPLEXES  
This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to catalysts and catalytic methods for reduction of molecular nitrogen. The molecular...
US20150104293 V-SHAPED ARRANGEMENTS OF TURBINES  
A V-shaped arrangement of turbines adapted to orient in such a manner that crosswind enters the arrangement in a direction that is substantially parallel to the axis bisecting the arrangement is...
US20150104191 AMPLIFICATION-FREE ELECTRO-OPTICAL OSCILLATOR  
An electro-optical oscillator includes, in part, a modulator, a signal splitter, N photodiodes with N being an integer greater than one, a signal combiner, and a filter. The modulator modulates an...