Patents and Patent Applications from California Institute of Technology


Match Document Document Title
9133504 Real time microarrays  
This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time. The method involves contacting a fluid volume having a...
9133457 Methods of incorporating amino acid analogs into proteins  
The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA,...
9132097 Nanoparticles stabilized with nitrophenylboronic acid compositions  
Described herein are carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to...
US20150255637 PHOTOVOLTAIC DEVICES INCORPORATING THIN CHALCOGENIDE FILM ELECTRICALLY INTERPOSED BETWEEN PNICTIDE-CONTAINING ABSORBER LAYER AND EMITTER LAYER  
The present invention provides strategies for improving the quality of the insulating layer in MIS and SIS devices in which the insulator layer interfaces with at least one pnictide-containing...
US20150254573 ALTERNATIVE TRAINING DISTRIBUTION DATA IN MACHINE LEARNING  
Technologies are generally described for methods and systems in a machine learning environment. In some examples, a method may include retrieving training data from a memory. The training data may...
US20150253196 UNCOOLED IR DETECTOR ARRAYS BASED ON NANOELECTROMECHANICAL SYSTEMS  
We describe the use of a high-quality-factor torsional resonator of microscale dimensions. The resonator has a paddle that is supported by two nanoscale torsion rods made of a very low thermal...
9130742 Key agreement in wireless networks with active adversaries  
A network and related methods for transmitting processes in a network secretly and securely is described. The network use keys, through path-key establishment and a key pool bootstrapping, to...
9128124 Wireless voltage sensing device  
A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and...
9127173 Antimicrobial materials  
The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to...
9127096 Methods and systems for synthesis of an ultra high molecular weight polymer  
A method for controlling the physical state of an ultra-high molecular weight polymer to make the ultra-high molecular weight polymer suitable for further processing, and related polymers...
9126175 High-throughput screening and device for photocatalysts  
The disclosure relates to compositions, devices and methods for screening of photocatalysts for water-splitting.
9125655 Correction and optimization of wave reflection in blood vessels  
The present invention provides methods and modalities that can modify wave reflection in the vascular system in order to create constructive interactions between existing wave dynamics and new...
US20150249456 MERCURY TRAPPED ION FREQUENCY STANDARD FOR ULTRA-STABLE REFERENCE APPLICATIONS  
An atomic clock including an ion trap assembly, a C-field coil positioned for generating a first magnetic field in the interrogation region of the ion trap assembly, a compensation coil positioned...
US20150247190 METHODS AND SYSTEMS FOR MICROFLUIDICS IMAGING AND ANALYSIS  
Disclosed herein are methods and devices for assessing sample for the presence of a disease or organism using images from devices such as a consumer cell phones.
US20150246140 COMPOSITIONS AND METHODS FOR MODULATING SLEEP AND WAKEFULNESS  
In some aspects, the invention relates to methods of treating conditions associated with sleep disorders, comprising administering an agent that modulates the activity of a neuropeptide receptor...
9124373 Integrated optical phased array  
An integrated optical phased array includes an input channel receiving an optical input signal, and a multitude of signal processing channels each adapted to supply an associated optical output...
9123622 Atomic layer deposition of high performance anti reflection coatings on delta-doped CCDs  
A back-illuminated silicon photodetector has a layer of Al2O3 deposited on a region of a silicon oxide surface that is left uncovered, while deposition is inhibited in another region by a contact...
9122956 Automated feature analysis, comparison, and anomaly detection  
Novel methods and systems for automated data analysis are disclosed. Data can be automatically analyzed to determine features in different applications, such as visual field analysis and...
9120732 Catalytic anti-markovnikov oxidation and hydration of olefins  
The disclosure provides a dual-catalysis system for direct conversion of olefins to alcohols. The cooperative catalytic system contains one oxidizing catalyst and one transfer-hydrogenation...
9119447 Amorphous platinum-rich alloys  
According to embodiments of the present invention, an amorphous alloy includes at least Pt, P, Si and B as alloying elements, and has a Pt weight fraction of about 0.925 or greater. In some...
US20150241342 DIGITAL PHASE CONJUGATION USING MOVING TARGET AS GUIDE STAR  
A method for irradiating a scattering medium, including irradiating a scattering medium with radiation from a laser, to form scattered radiation having a scattered field; measuring a difference in...
US20150238960 MICROFLUIDIC NUCLEIC ACID ANALYSIS  
Nucleic acid from cells and viruses sampled from a variety of environments may purified and expressed utilizing microfluidic techniques. In accordance with one embodiment of the present invention,...
US20150238742 DRUG DELIVERY AND SUBSTANCE TRANSFER FACILITATED BY NANO-ENHANCED DEVICE HAVING ALIGNED CARBON NANOTUBES PROTRUDING FROM DEVICE SURFACE  
The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes...
US20150237838 REGULATION OF INSECT POPULATIONS  
The present technology generally relates to compositions, methods, and populations that allow for the regulation of insect population.
RE45658 Method of manufacturing amorphous metallic foam  
Metallic foams comprising high viscosity materials and apparatuses and methods of manufacturing such foams, and more particularly methods for controllably manufacturing metallic foams from...
9116128 Click chemistry surface functionalization for resonant micro-cavity sensors  
Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional...
9115424 Simple method for producing superhydrophobic carbon nanotube array  
Efficient methods for producing a superhydrophobic carbon nanotube (CNT) array are set forth. The methods comprise providing a vertically aligned CNT array and performing vacuum pyrolysis on the...
9115355 Exonuclease resistant polynucleotide and related duplex polynucleotides, constructs, compositions, methods and systems  
Provided herein are exonuclease resistant polynucleotides and related constructs, compositions, methods and systems.
US20150236789 DUAL-FREQUENCY OPTICAL SOURCE  
A dual-frequency optical source comprises: (a) first and second pump laser sources arranged to generate optical pump power at respective first and second pump laser frequencies vpump1 and vpump2;...
US20150236784 STABILIZED MICROWAVE-FREQUENCY SOURCE  
A microwave-frequency source at frequency fM comprises: a dual optical-frequency reference source, an electro-optic sideband generator, an optical bandpass filter, an optical detector, a reference...
US20150236396 DIELECTRIC WAVEGUIDES SPLITTER AND HYBRID/ISOLATOR FOR BIDIRECTIONAL LINK  
A system, method, device, and apparatus provide a dielectric waveguide splitter/bi-directional link. A dielectric substrate fabricated into a first Y-junction waveguide with a first port splitting...
US20150234052 REAL-TIME AND POST-PROCESSED ORBIT DETERMINATION AND POSITIONING  
Novel methods and systems for the accurate and efficient processing of real-time and latent global navigation satellite systems (GNSS) data are described. Such methods and systems can perform...
US20150232822 DNA POLYMERASES HAVING IMPROVED LABELED NUCLEOTIDE INCORPORATION PROPERTIES  
The present invention relates to mutant DNA polymerases that exhibit reduced discrimination against labeled nucleotides into polynucleotides. The DNA polymerases of the invention have at least one...
US20150232814 METHODS AND SYSTEMS FOR SULFIMIDATION OR SULFOXIMIDATION OF ORGANIC MOLECULES  
The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.
US20150231675 SHEET FORMING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
US20150231396 Neurostimulator  
A neurostimulator devices and systems for use with groups of electrodes placed within a subject's body. The devices and systems can include training devices and/or pulse generation systems.
9108982 Diels-alder reactions catalyzed by lewis acid containing solids: renewable production of bio-plastics  
The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and...
9108979 Diels-Alder reactions catalyzed by Lewis acid containing solids: renewable production of bio-plastics  
The present disclosure is related to silica-based Lewis acid catalysts, being essentially devoid of strong Brønsted acid character, and their ability to effect the [4+2] cycloaddition and...
US20150225803 MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES  
Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting...
US20150225801 RECORDING AND MAPPING LINEAGE INFORMATION AND MOLECULAR EVENTS IN INDIVIDUAL CELLS  
Methods and systems for recording and mapping lineage information and molecular events in individual cells are provided. Molecular changes, which may result from random or specific molecular...
US20150223739 REFLOWED GOLD NANOSTRUCTURES FOR SURFACE ENHANCED RAMAN SPECTROSCOPY  
Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the...
US20150223738 PLASMONICS NANOSTRUCTURES FOR MULTIPLEXING IMPLANTABLE SENSORS  
Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the...
US20150223701 BREATHING AND HEARTBEAT FEATURE EXTRACTION AND VICTIM DETECTION  
Systems and methods for detecting biometrics using a life detecting radar are disclosed. Life detecting radars can include transmit antennas configured to transmit continuous microwave (“CW”)...
9105548 Sparsely-bonded CMOS hybrid imager  
A method and device for imaging or detecting electromagnetic radiation is provided. A device structure includes a first chip interconnected with a second chip. The first chip includes a detector...
9103786 Apparatus for detecting target molecules and related methods  
An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence...
9102520 Nanocomposite structures and related methods and systems  
The disclosure relates to nanotube composite structures and related methods and systems. In particular, structures, methods and systems are provided herein to allow for precise, tunable separation...
9101979 Methods for fabricating gradient alloy articles with multi-functional properties  
Systems and methods for fabricating multi-functional articles comprised of additively formed gradient materials are provided. The fabrication of multi-functional articles using the additive...
9101769 High density epidural stimulation for facilitation of locomotion, posture, voluntary movement, and recovery of autonomic, sexual, vasomotor, and cognitive function after neurological injury  
Methods of enabling locomotor control, postural control, voluntary control of body movements (e.g., in non-weight bearing conditions), and/or autonomic functions in a human subject having spinal...
US20150222092 III-V PHOTONIC CRYSTAL MICROLASER BONDED ON SILICON-ON-INSULATOR  
Novel methods and systems for miniaturized lasers are described. A photonic crystal is bonded to a silicon-on-insulator wafer. The photonic crystal includes air-holes and can include a waveguide...
US20150222073 METHODS OF MODULATING MICROLASERS AT ULTRALOW POWER LEVELS, AND SYSTEMS THEREOF  
A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least...