Patents and Patent Applications from California Institute of Technology


Match Document Document Title
US20160025626 SILICON PHOTONIC CRYSTAL NANOBEAM CAVITY WITHOUT SURFACE CLADDING AND INTEGRATED WITH MICRO-HEATER FOR SENSING APPLICATIONS  
A silicon photonic crystal nanobeam cavity device is described, including a heater that can set a desired temperature on the cavity device in order to control its resonant wavelength. The device...
US20160024482 ALKANE OXIDATION BY MODIFIED HYDROXYLASES  
This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable...
US20160024244 Periodic Nanostructures From Self Assembled Wedge-Type Block-Copolymers  
The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing...
US20160023352 SURROGATE: A Body-Dexterous Mobile Manipulation Robot with a Tracked Base  
Robotics platforms in accordance with various embodiments of the invention can be utilized to implement highly dexterous robots capable of whole body motion. Robotics platforms in accordance with...
US20160022727 IMMUNOMODULATING COMPOUNDS AND RELATED COMPOSITIONS AND METHODS  
Provided herein are compounds, compositions and methods for balancing a T-helper cell profile and in particular Th1, Th2, Th17 and Treg cell profiles, and related methods and compositions for...
9247235 Method and device for high-resolution imaging which obtains camera pose using defocusing  
A method and device for high-resolution three-dimensional (3-D) imaging which obtains camera pose using defocusing is disclosed. The device comprises a lens obstructed by a mask having two sets of...
9246529 Photonic RF down-converter based on optomechanical oscillation  
An all optical radio frequency converter. The invention relates to a microtoroid optomechanical oscillator that can provide a local oscillation frequency and a mixing functionality. The...
9243277 Sensor probe for bio-sensing and chemical-sensing applications  
The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example...
9243015 Metallocorroles  
Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes....
US20160019334 MULTIPLEX ANALYSIS OF MOLECULES IN SINGLE CELLS BY IMAGE CORRELATION  
Disclosed herein are methods and systems for analyzing visual data from multiple rounds of hybridization interactions where the same molecular target is detected by probes with different...
US20160015879 CORRECTION AND OPTIMIZATION OF WAVE REFLECTION IN BLOOD VESSELS  
The present invention provides methods and modalities that can modify wave reflection in the vascular system in order to create constructive interactions between existing wave dynamics and new...
US20160015266 SYSTEMS AND METHODS FOR SENSING INTRAOCULAR PRESSURE  
Systems and methods of sensing intraocular pressure are described. An example miniaturized intraocular pressure (IOP) monitoring system is provided using a nanophotonics-based implantable IOP...
9238833 Thermally controlled chamber with optical access for high-performance PCR  
Novel methods and systems for polymerase chain reaction (PCR) are disclosed. A PCR device has a bottom heater layer, a central reacting layer, and a top heater layer. The central reacting layer...
9238709 Latent, high-activity olefin metathesis catalysts containing an N-heterocyclic carbene ligand  
The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an N-heterocyclic carbene ligand and a chelating carbene ligand associated with a...
US20160011189 ARRAYS, SUBSTRATES, DEVICES, METHODS AND SYSTEMS FOR DETECTING TARGET MOLECULES  
Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and...
US20160009574 ELECTROLYSIS ELECTRODE  
A water purification anode has a first semiconductor contacting a second semiconductor at a heterojunction. The second semiconductor includes TiO2 and excludes bismuth and niobium. The first...
US20160008988 Robotics Platforms Incorporating Manipulators Having Common Joint Designs  
Manipulators in accordance with various embodiments of the invention can be utilized to implement statically stable robots capable of both dexterous manipulation and versatile mobility....
9234985 Birefringent polymer brush structures formed by surface initiated ring-opening metathesis polymerization  
The disclosure describes a polymer brush structure exhibiting birefringence, said polymer brush structure comprising a plurality of substantially parallel oriented polymers and characterized by a...
9234884 Microfluidic device  
Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device...
9234882 Translocation and nucleotide reading mechanisms for sequencing nanodevices  
By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are...
9234872 Chemical sensing and/or measuring devices and methods  
Methods for fabricating silicon nanowire chemical sensing devices, devices thus obtained, and methods for utilizing devices for sensing and measuring chemical concentration of selected species in...
9233996 Multi-metallic organometallic complexes, and related polymers, compositions, methods and systems  
Multi-metallic organometallic complexes that allow performance of olefin based reaction and in particular polymerization of olefins to produce polyolefin polymers, and related methods and systems...
9233369 Fluidic devices and fabrication methods for microfluidics  
A method of fabricating a fluidic device comprises providing a fluidic device including a body having a surface and one or more channels located in the body. Recesses are defined on said surface....
US20160005786 ATOMICALLY PRECISE SURFACE ENGINEERING FOR PRODUCING IMAGERS  
High-quality surface coatings, and techniques combining the atomic precision of molecular beam epitaxy and atomic layer deposition, to fabricate such high-quality surface coatings are provided....
US20160005566 METHOD AND SYSTEM FOR ELECTRON MICROSCOPE WITH MULTIPLE CATHODES  
An electron microscope system includes a laser system operable to generate an optical pulse and a pump pulse and a microscope column. The microscope column includes a multiple cathode structure...
US20160002682 IN VIVO AND IN VITRO OLEFIN CYCLOPROPANATION CATALYZED BY HEME ENZYMES  
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the...
US20160000934 NANOPARTICLES STABILIZED WITH NITROPHENYLBORONIC ACID COMPOSITIONS  
Described herein are polymer conjugates comprising a polymer containing a polyol coupled to a polymer containing a nitroboronic acid.
9231180 Nanostructured silicide composites for thermoelectric applications  
The present invention provides a method of preparing a nanocomposite thermoelectric material. The method includes heating a reaction mixture of a semiconductor material and a metal complex to a...
9230652 Flash memories using minimum push up, multi-cell and multi-permutation schemes for data storage  
Rank modulation has been recently proposed as a scheme for storing information in flash memories. Three improved aspects are disclosed. In one aspect the minimum push-up scheme, for storing data...
9228240 Methods for detecting and quantifying viable bacterial endo-spores  
Methods and systems for detecting viable bacterial endospores in a sample and related methods to quantify viable bacterial endospores in a sample.
US20150380989 METHODS FOR OPTICALLY POWERING TRANSDUCERS AND RELATED TRANSDUCERS  
The present disclosure describes a method for optically powering transducers and related transducers with a photovoltaic collector. An optical fiber power delivery method and a free space power...
US20150380767 CROSSLINKED POLYMER ELECTROLYTE  
A composite electrolyte can include a crosslinked polymer formed from telechelic precursor polymers having at least two photoactivatable end functional groups and a molecular weight before...
US20150375227 Microfabricated Crossflow Devices and Methods  
This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion...
9225069 Efficient active multi-drive radiator  
An integrated Multi-Port Driven (MPD) antenna that can be driven at many points with different signals. An integrated MPD radiating source utilizing an 8-phase ring oscillator and eight power...
9223929 Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays  
The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provides methods and computer implemented techniques for reducing...
9222159 Bulk metallic glass matrix composites  
A method of forming bulk metallic glass engineering materials, and more particularly a method for forming coarsening microstructures within said engineering materials is provided. Specifically,...
9221919 Functionalization of and use of functionalized second harmonic generating nanoprobes  
Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processeses using a variety of imaging techniques are provided....
US20150371929 IMPLANT DEVICE AND METHOD OF MAKING THE SAME  
The invention provides chip packaging and processes for the assembly of retinal prosthesis devices. Advantageously, photo-patternable adhesive or epoxy such as photoresist is used as glue to...
US20150369809 TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER  
The present invention relates to methods of treating cancer, suppressing or inhibiting tumorigenesis, tumor growth or cancer progression, and suppressing or inhibiting cancer cells from altering...
US20150369220 MANIPULATION OF FLEXIBLE MATERIALS THROUGH SELF-PROPELLED BODIES  
A system is described comprising self-propelled bodies such as bacteria or nanoparticles, which can be activated with an external field to move in a desired direction. The self-propelled bodies,...
US20150368811 HIGHLY ACTIVE MIXED-METAL CATALYSTS MADE BY PULSED-LASER ABLATION IN LIQUIDS  
The invention is directed to mixed-metal nanocatalysts, particularly nano-dimensioned layered double-hydroxide nanostacks, methods of making nanocatalysts using laser ablation techniques, and the...
US20150368111 METHOD AND SYSTEM FOR GRAPHENE FORMATION  
A system for graphene production includes a plurality of gas sources, a plurality of mass flow controllers, and a processing chamber. The system also includes a plasma source operable, a vacuum...
US20150366707 SMALL MOLECULE TRANSPORT DEVICE FOR DRUG DELIVERY OR WASTE REMOVAL  
A medical device having a permeable bag connected by a non-permeable cannula to a discharge sac is described along with a manufacturing process and surgical implantation method. The permeable...
9219907 Method and apparatus for quantitative 3-D imaging  
Described is a method and apparatus for obtaining additional information from an object and a method for surface imaging and three-dimensional imaging. Single lens, single aperture, single sensor...
9219486 Quadrature-based injection locking of ring oscillators  
Technologies are generally described for quadrature-based injection-locking of ring oscillators. In some examples, an external signal may be injected into a ring oscillator. Phase signals may be...
9217151 Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways  
The present invention relates generally to programming of biomolecular self-assembly pathways and related methods and constructs. A versatile nucleic acid hairpin motif for programming...
US20150359668 LIGHT DELIVERY DEVICE AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Devices and systems for delivering light to a target are described. Methods of using such light delivery device and system are also described. A method of using a photosensitizing compound with...
9215114 Double-sampling receiver with dynamic offset modulation for optical and electrical signaling  
A receiver architecture is disclosed which employs an RC double-sampling front-end and dynamic offset modulation technique. A low-voltage double-sampling technique provides high power efficiency...
9214811 Devices and methods for harvesting power from arrays of wind turbines  
Variable frequency alternate current (VFAC) bus arrangements and systems using such VFAC bus arrangements are described, such as arrays of turbines. Such systems have a centrally located power...
9214787 III-V photonic crystal microlaser bonded on silicon-on-insulator  
Novel methods and systems for miniaturized lasers are described. A photonic crystal is bonded to a silicon-on-insulator wafer. The photonic crystal includes air-holes and can include a waveguide...