Patents and Patent Applications from California Institute of Technology


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US20140316503 PARYLENE-BASED MICROELECTRODE ARRAY IMPLANT FOR SPINAL CORD STIMULATION  
An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion...
US20140316261 Life Detecting Radars  
Systems and methods for detecting biometrics using a life detecting radar are disclosed. Life detecting radars can include transmit antennas configured to transmit continuous microwave (“CW”)...
US20140316149 ALDEHYDE-SELECTIVE WACKER-TYPE OXIDATION OF UNBIASED ALKENES  
This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium...
US20140315955 STIMULI RESPONSIVE ADHESIVE GEL FOR REMOVAL OF FOREIGN PARTICLES FROM SOFT TISSUE  
The present inventions are directed to novel aqueous compositions comprising a copolymer having water-soluble units and pendant catechols, said composition adapted for use on mammalian tissue and...
US20140315093 USE AND FABRICATION OF MICROSCAFFOLDS AND NANOSCAFFOLDS  
A scaffold includes struts that intersect at nodes. In some instances, a cross section of the cores has at least one dimension less than 100 microns. The core can be a solid, liquid or a gas. In...
US20140312739 HIGH TEMPERATURE ULTRASONIC PROBE AND PULSE-ECHO PROBE MOUNTING FIXTURE FOR TESTING AND BLIND ALIGNMENT ON STEAM PIPES  
A high temperature ultrasonic probe and a mounting fixture for attaching and aligning the probe to a steam pipe using blind alignment. The high temperature ultrasonic probe includes a...
US20140312098 SYSTEMS AND METHODS FOR FABRICATING STRUCTURES INCLUDING METALLIC GLASS-BASED MATERIALS USING ULTRASONIC WELDING  
Systems and methods in accordance with embodiments of the invention fabricate objects including metallic glass-based materials using ultrasonic welding. In one embodiment, a method of fabricating...
US20140311890 PHOTOACID COMPOUNDS, AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
A photoacid compound having a light absorbing moiety attaching a payload moiety through a linker, in which the linker comprises a geminal dialkyl linked to a carbonyl group attaching the payload...
8866007 Plasmonic photovoltaics  
A surface plasmon polariton photovoltaic absorber. A plasmonic photovoltaic device is provided that has a periodic subwavelength aperture array, for example a thin metal film coated with an array...
8865881 Delivery of proteins using adeno-associated virus (AAV) vectors  
Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
8865876 Engineered lectin oligomers with antiviral activity  
Engineered lectins and methods of using such reagents for both preventing and treating a broad array of viral infections are provided. The lectins of the invention are engineered in two ways,...
8865708 Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase  
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are...
8865667 Higher-order cellular information processing devices  
The invention provides various signal processing devices for integrating two or more biological signals (e.g., the presence, absence or concentration of specific ligands, etc.) to generate a...
US20140309415 CONVERSION OF GLUCOSE TO SORBOSE  
The present invention is directed to methods for preparing sorbose from glucose, said method comprising: (a) contacting the glucose with a silica-containing structure comprising a zeolite having a...
US20140308713 ENDOGLUCANASE HAVING ENHANCED THERMOSTABILITY AND ACTIVITY  
A variant Cel5a endoglucanase has increased thermostability, increased enzymatic activity and/or increased expression in a host, relative to wild type Cel5a. The improved variant Cel5a...
US20140308208 CAGED COMPOUND DELIVERY AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Methods are described and related devices, compositions, and systems, in which a caged compound is administered to a biological environment, the caged compound being caged with a long wavelength...
8859533 Metalloinsertor complexes targeted to DNA mismatches  
A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the...
8857275 NEMS sensors for cell force application and measurement  
An apparatus, system, device, and method provide the ability to measure forces a cell exerts on its surroundings. A platform is suspended across an opening using support legs. The platform is able...
US20140303360 Small Molecule Compounds for the Control of Nematodes  
The present invention relates to compounds involved in nematode signaling.
US20140303102 Small Molecule Compounds that Control Mammal-Pathogenic Nematodes  
The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode...
US20140301694 NANOSCALE PLASMONIC FIELD-EFFECT MODULATOR  
A plasmonic device having a transparent conducting oxide (TCO) waveguide and a tunable voltage applied across the TCO and a metal layer for modulating an input optical signal.
US20140301418 PHOTONIC CRYSTAL CAVITIES AND RELATED DEVICES AND METHODS  
Photonic crystal cavities and related devices and methods are described. The described cavities can be used as lasers, photovoltaic sources, and single photon sources. The cavities can be both...
US20140298918 BROADBAND ELECTROMECHANICAL SPECTROSCOPY  
An apparatus, method, and material wherein the material's viscoelastic and/or fatigue life may be altered by application of a secondary tuning electromagnetic field or a selected temperature, and...
8850792 Microfluidic electrospray thruster  
An electrospray thruster and methods of manufacturing such thrusters are provided. The micro-electrospray thruster increases the thrust density of conventional electrospray thrusters by...
US20140296780 POLYMER COMPOSITE CARBON NANOTUBE MICRONEEDLE DEVICES AND THEIR FABRICATION  
Composite CNT microneedle fabrication and finally-constructed delivery device embodiments are described. The microneedles can provide a self-administered, painless alternative to standard...
US20140295513 High-Performance Ketol-Acid Reductoisomerases  
The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or a modified NADH-dependent variant...
US20140295512 Ketol-Acid Reductoisomerases With Improved Performance Properties  
The present invention relates to recombinant microorganisms comprising at least one nucleic acid molecule encoding a ketol-acid reductoisomerase (KARI) or modified NADH-dependent variant thereof,...
US20140290381 INTEGRATED ENVIRONMENTAL SENSORS FOR HARSH ENVIRONMENT APPLICATIONS  
Systems and methods in accordance with embodiments of the invention implement integrated environmental sensors that can operate in rigorous environments. In one embodiment, an integrated...
8849483 Target trailing with safe navigation with colregs for maritime autonomous surface vehicles  
Systems and methods for operating autonomous waterborne vessels in a safe manner. The systems include hardware for identifying the locations and motions of other vessels, as well as the locations...
8849075 Systems and methods for tuning a cavity  
The present disclosure describes an integrated opto-mechanical and electro-mechanical system. The opto-mechanical and electro-mechanical system can be made of photonic crystals configured to move...
8848982 Image reconstruction by position and motion tracking  
A system, method, and apparatus provide the ability to reconstruct an image from an object. A hand-held image acquisition device is configured to acquire local image information from a physical...
8848760 On-chip optical reference cavity exhibiting reduced resonance center frequency fluctuations  
An optical apparatus comprises a waveguide substrate and an optical reference cavity. The optical reference cavity comprises an optical waveguide formed on the waveguide substrate and arranged to...
8846939 Imidazolidine-based metal carbene metathesis catalysts  
The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are wherein: M is ruthenium or...
8846183 Microfabricated elastomeric valve and pump systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
8846143 Method for selectively anchoring and exposing large numbers of nanoscale structures  
Methods for fastening nanoscale structures within an anchoring structure to form a nanostructure composite and nanostructure composites formed therefrom. A primary fluid layer is formed on an...
8845979 Thermal blood clot formation and use in microfluidic device valving applications  
The present invention provides a method of forming a blood-clot microvalve by heating blood in a capillary tube of a microfluidic device. Also described are methods of modulating liquid flow in a...
8844570 Generating binary states using a microfluidic channel  
Methods and devices for using one or more fluidic channels for generating binary states are described. In particular, the present teachings relate to incorporating such fluidic channels into...
US20140289246 Systems and Methods for the Distributed Categorization of Source Data  
Systems and methods for the crowdsourced clustering of data items in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining categories...
US20140288319 CROSS-METATHESIS REACTION OF FUNCTIONALIZED AND SUBSTITUTED OLEFINS USING GROUP 8 TRANSITION METAL CARBENE COMPLEXES AS METATHESIS CATALYSTS  
The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes...
US20140283906 SYSTEM AND METHOD FOR CONTROLLING AN INVERSION LAYER IN A PHOTOVOLTAIC DEVICE  
A semiconductor photovoltaic device with an absorber layer for absorbing incident light, and a light transmitting layer located on the semiconductor body. The light transmitting layer induces an...
8841712 Nano-pillar transistor fabrication and use  
A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar...
8841613 Method and system for 4D tomography and ultrafast scanning electron microscopy  
A 4D electron tomography system includes a stage having one or more degrees of freedom, an electron source, and electron optics operable to direct electron pulses to impinge on a sample supported...
8841083 PSA capture agents, compositions, methods and preparation thereof  
Disclosed herein are novel synthetic prostate specific antigen (PSA)-targeted capture agents that specifically bind PSA. In certain embodiments, these PSA capture agents are biligand or triligand...
US20140283155 REPRESSIBLE LETHAL SYSTEM FOR REGULATING INSECT POPULATIONS  
Disclosed herein are components, systems and methods for regulating population of multicellular organisms, for example insects.
US20140281345 Distributed Storage Allocation for Heterogeneous Systems  
Allocation of storage budget in a computer-based distributed storage system is described, where associated computer-based storage nodes have heterogeneous access probabilities. The problem is to...
US20140272667 BA-SR-CO-FE-O BASED PEROVSKITE MIXED CONDUCTING MATERIALS AS CATHODE MATERIALS FOR INTERMEDIATE TEMPERATURE SOLID OXIDE FUEL CELLS BOTH IN DUAL CHAMBER AND SINGLE CHAMBER CONFIGURATION  
Improved cathode active materials for reduced temperature operation in single and dual chamber solid oxide fuel cells are provided. The cathode active materials comprise perovskites of the general...
US20140272500 SYSTEMS AND METHODS FOR DETECTING ABNORMALITIES IN ELECTRICAL AND ELECTROCHEMICAL ENERGY UNITS  
A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy...
US20140271926 METHODS OF USE OF GLUTAMINE SYNTHETASE INHIBITORS  
A method of treating neoplastic growth in a subject includes administering a glutamine synthetase (GS) inhibitor to the subject having neoplastic growth. A glutamine synthetase inhibitor may be...
US20140259887 ASSOCIATIVE POLYMERS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Described herein are associative polymers capable of controlling one or more physical and/or chemical properties of non-polar compositions and related compositions, methods and systems.
8838507 Active learning decision engines  
Systems and methods for active learning decision engines in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an active learning decision engine...