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Patents and Patent Applications from California Institute of Technology


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8722371 Cytochrome P450 oxygenases  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher...
8721892 Integrated chromatography devices and systems for monitoring analytes in real time and methods for manufacturing the same  
Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple...
8720614 Robotic two-wheeled vehicle  
A robotic two-wheeled vehicle comprising a connection body interposed between the two wheels are described. A drum can be coaxially located in a central region of the connection body and can...
8720250 Systems and methods for controlling highly nonlinear acoustic waves or pulses  
Systems and methods for creating sound bullets are described. Such sound bullets are created by controlling and/or redirecting highly nonlinear acoustic waves or pulses propagating through an...
US20140128494 ON-DEMAND PHOTOINITIATED POLYMERIZATION  
Compositions and methods for adjustable lenses are provided. In some embodiments, the lenses contain a lens matrix material, a masking compound, and a prepolymer. The lens matrix material provides...
US20140127796 INSTRUMENTS FOR BIOLOGICAL SAMPLE-TO-ANSWER DEVICES  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or...
US20140127790 INSTRUMENTS FOR BIOLOGICAL SAMPLE PREPARATION DEVICES  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or...
US20140127777 METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS  
The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and...
US20140127162 REVERSIBLE GENE EXPRESSION  
According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral vectors encoding a gene product of...
US20140126691 Fourier Ptychographic X-ray Imaging Systems, Devices, and Methods  
Methods, systems, and devices of Fourier ptychographic X-ray imaging by capturing a plurality of variably-illuminated, low-resolution intensity X-ray images of a specimen and computationally...
8717574 Turbidity suppression by optical phase conjugation using a spatial light modulator  
A detector of light transmitted through a turbid medium, comprising: one or more Digital Optical Phase Conjugation (DOPC) devices, wherein the DOPC devices include (1) a sensor for detecting input...
8715988 Alkane oxidation by modified hydroxylases  
This invention relates to modified hydroxylases. The invention further relates to cells expressing such modified hydroxylases and methods of producing hydroxylated alkanes by contacting a suitable...
8715640 Packaging cells for producing retrovirus pseudotyped with an E2 alphavirus glycoprotein  
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific...
8715345 Accommodating intraocular lens  
Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable...
US20140118739 TIME-REVERSAL OF VARIANCE-ENCODED LIGHT (TROVE)  
A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside...
US20140118529 Fourier Ptychographic Imaging Systems, Devices, and Methods  
Systems, devices, and methods of Fourier ptychographic imaging by computationally reconstructing a high-resolution image by iteratively updating overlapping regions of variably-illuminated,...
US20140118143 WIRELESS SENSOR NODE FOR AUTONOMOUS MONITORING AND ALERTS IN REMOTE ENVIRONMENTS  
A method, apparatus, system, and computer program products provides personal alert and tracking capabilities using one or more nodes. Each node includes radio transceiver chips operating at...
8710199 Signal activated molecular delivery  
Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.
8709153 Microfludic protein crystallography techniques  
The present invention relates to microfluidic devices and methods facilitating the growth and analysis of crystallized materials such as proteins. In accordance with one embodiment, a crystal...
8709152 Microfluidic free interface diffusion techniques  
A static fluid and a second fluid are placed into contact along a microfluidic free interface and allowed to mix by diffusion without convective flow across the interface. In accordance with one...
8707545 Single layer PCB microfluidics  
A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal...
US20140113811 NANOSTRUCTURED CARBON MATERIALS FOR ADSORPTION OF METHANE AND OTHER GASES  
Provided are methods for storing gases on porous adsorbents, methods for optimizing the storage of gases on porous adsorbents, methods of making porous adsorbents, and methods of gas storage of...
US20140112779 FEATURES FOR FLAG-TYPE POWER GENERATION  
Flag-type wind and/or water power generation features are described. Fluid-filled embodiments are described. The fluid may be employed for pumping effect and/or dynamic physical property change....
US20140112778 FLEXIBLE BLADES FOR WIND TURBINE DESIGN  
Flag-type wind and/or water power generation features are described. Fluid-filled embodiments are described. The fluid may be employed for pumping effect and/or dynamic physical property change....
US20140110944 FLAG INSTABILITY FOR DIRECT MECHANICAL POWER GENERATION  
Flag-type wind and/or water power generation features are described. Fluid-filled embodiments are described. The fluid may be employed for pumping effect and/or dynamic physical property change....
US20140110612 HYDRAULIC HIGH PRESSURE VALVE CONTROLLER USING THE IN-SITU PRESSURE DIFFERENCE  
A hydraulic vale controller that uses an existing pressure differential as some or all of the power source for valve operation. In a high pressure environment, such as downhole in an oil or gas...
8706729 Systems and methods for distributed data annotation  
Systems and methods for distributed data annotation in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a distributed data annotation server system...
8703965 Preparation of saturated imidazolinium salts and related compounds  
Methods for the preparation of saturated imidazolinium salts and related compounds that comprises reaction of formamidines with compounds such as dihaloethane and an optional base are disclosed....
8702788 Expandable stent that collapses into a non-convex shape and expands into an expanded, convex shape  
An expandable stent that can transform between a collapsed state and an expanded state is described. The stent includes a first cross-sectional shape and a second cross-sectional shape. The first...
US20140107983 SYSTEMS AND METHODS OF DESIGNING NUCLEIC ACIDS THAT FORM PREDETERMINED SECONDARY STRUCTURE  
Described is a system and process for designing the equilibrium base-pairing properties of a test tube of interacting nucleic acid strands. A target test tube is specified as a set of desired...
US20140107954 APPARATUS FOR AND METHOD OF MONITORING CONDENSED WATER IN STEAM PIPES AT HIGH TEMPERATURE  
A system and method for monitoring the properties of a fluid, such as water, in a steam pipe without mechanically penetrating the wall of the pipe. The system uses a piezoelectric transducer to...
US20140106960 Z-SELECTIVE OLEFIN METATHESIS CATALYSTS AND THEIR SYNTHETIC PROCEDURE  
The invention relates to C—H activated olefin metathesis catalyst compounds, the preparation of such compounds, and the use of such catalysts in the metathesis of olefins and olefin compounds,...
US20140106393 METHODS AND SYSTEMS FOR DETECTION OF STOICHIOMETRY BY FORSTER RESONANCE ENERGY TRANSFER  
Methods to detect stoichiometries of protein complexes and/or interactions between proteins based on detection and quantification of FRET and related systems and compositions.
US20140105232 ON-CHIP OPTICAL REFERENCE CAVITY EXHIBITING REDUCED RESONANCE CENTER FREQUENCY FLUCTUATIONS  
An optical apparatus comprises a waveguide substrate and an optical reference cavity. The optical reference cavity comprises an optical waveguide formed on the waveguide substrate and arranged to...
US20140104593 THREE-DIMENSIONAL TOMOGRAPHIC IMAGING CAMERA BASED ON COMPRESSIVE SENSING  
A detection apparatus and method for FMCW LIDAR employ signals that are modified so that low-cost and low-speed photodetector arrays, such as CCD or CMOS cameras, can be employed for range...
US20140104390 SINGLE-LENS, SINGLE-SENSOR 3-D IMAGING DEVICE WITH A CENTRAL APERTURE FOR OBTAINING CAMERA POSITION  
A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an...
US20140103735 SYSTEMS AND METHODS FOR WIRELESS TRANSDUCERS THROUGH INTEGRATED ON-CHIP ANTENNA  
Novel methods and systems for wireless sensors are described. The systems can comprise an energy-harvesting unit, a transducer, and electronic control circuit, and an antenna. All elements can be...
US20140102163 FORMING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE FORGING  
A forging apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming...
8698498 Low field squid MRI devices, components and methods  
Low field SQUID MRI devices, components and methods are disclosed. They include a portable low field (SQUID)-based MRI instrument and a portable low field SQUID-based MRI system to be operated...
8697672 Microrna inhibition for the treatment of inflammation and myeloproliferative disorders  
The present disclosure relates to the finding that microRNA-155 plays a role in inflammation, hematopoiesis and myeloproliferation, and that dysregulation of microRNA-155 expression is associated...
8697474 Methods to fabricate and improve stand-alone and integrated filters  
Embodiments of the invention provide for fabricating a filter, for electromagnetic radiation, in at least three ways, including (1) fabricating integrated thin film filters directly on a detector;...
8695640 Microfabricated elastomeric valve and pump systems  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
8695355 Thermal management techniques, apparatus and methods for use in microfluidic devices  
A heating/cooling device for a microfluidic apparatus having a thermal insulating substrate. The device includes heating/cooling chamber for heating and/or cooling a sample disposed in the...
US20140100651 Medical Device Fastener Mechanisms  
Connecting mechanisms between medical device or other physical components are described. One or more plug pin connector(s) is received in a matching socket connector(s) to either permanently or...
US20140100102 DEVICES AND METHODS FOR CELL LYSIS AND SAMPLE PREPARATION THROUGH CENTRIFUGATION  
Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device comprises strips of centrifuge tubes and elements to create a magnetic field. The magnetic...
US20140099732 OPTICAL SENSOR FOR ANALYTE DETECTION  
Devices, systems, and methods for detection of an analyte in a sample are disclosed. In some embodiments, an optical sensor can include a metallic layer and a plurality of dielectric pillars...
US20140099573 PHOTOINITIATED OLEFIN METHATHESIS POLYMERIZATION  
The present invention provides photosensitive compositions and methods of patterning a polymeric image on a substrate, said methods comprising; (a) depositing a layer of photosensitive composition...
US20140097562 TUNABLE PASSIVE VIBRATION SUPPRESSOR  
An apparatus and method for vibration suppression using a granular particle chain. The granular particle chain is statically compressed and the end particles of the chain are attached to a payload...
US20140097391 NANOSTRUCTURED SILICIDE COMPOSITES FOR THERMOELECTRIC APPLICATIONS  
The present invention provides a method of preparing a nanocomposite thermoelectric material. The method includes heating a reaction mixture of a semiconductor material and a metal complex to a...
US20140097338 MASS SPECTROMETER, SYSTEM COMPRISING THE SAME, AND METHODS FOR DETERMINING ISOTOPIC ANATOMY OF COMPOUNDS  
A first mass spectrometer includes a first introduction device configured to select between a reference material and a first portion of an analyte and introduce the selected one of the reference...