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Patents and Patent Applications from California Institute of Technology


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US20130137135 COMPOSITIONS AND METHODS FOR LEUKOCYTE DIFFERENTIAL COUNTING  
The present invention provide compositions and methods for classifying leukocytes in a leukocyte population using fluorescence detection. The methods include contacting a leukocyte population in a...
US20130133711 PLASMONIC NANOSTRUCTURES FOR CONVERSION OF OPTICAL POWER TO ELECTRICAL POWER  
A plasmoelectric device for conversion of optical power to direct current (DC) electrical power includes a first plasmonic nanostructure having a first resonance value and a second plasmonic...
US20130133439 NEMS SENSORS FOR CELL FORCE APPLICATION AND MEASUREMENT  
An apparatus, system, device, and method provide the ability to measure forces a cell exerts on its surroundings. A platform is suspended across an opening using support legs. The platform is able...
8452123 Distortion calibration for optical sensors  
A method for calibrating an imaging instrument, possibly located on an aircraft or satellite, is described. According to the method, an image acquired by the instrument is ortho-rectified, and then...
8450674 Acoustic assisted phase conjugate optical tomography  
A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic...
US20130130254 OPTICAL RESONATOR DIAGNOSTIC DEVICE AND METHODS OF USE  
An implantable diagnostic device in accordance with the present disclosure provides various benefits such as a compact size thereby allowing implanting of the device inside animate objects; low...
US20130129628 FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES  
Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processeses using a variety of imaging techniques are provided. The...
US20130128227 SYSTEMS AND METHODS FOR NONINVASIVE ANALYSIS OF RETINAL HEALTH AND FUNCTION  
A method for noninvasive analysis of a retina includes exposing the retina to one or more first sets of at least three illumination light signals. The at least three illumination light signals each...
US20130125621 SYSTEM FOR ANALYZING A GAS MIXTURE INCLUDING AT LEAST ONE CHROMATOGRAPHY COLUMN  
A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture,...
8446127 Methods for thermodynamic evaluation of battery state of health  
Described are systems and methods for accurately characterizing thermodynamic and materials properties of electrodes and battery systems and for characterizing the state of health of electrodes and...
8445210 Microfabricated crossflow devices and methods  
A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for...
8444745 Amorphous metal foam as a property-matched bone scaffold substitute  
Amorphous metal foams and methods of making the same are provided. The amorphous metal foams have properties matching those of natural bone, enabling their use as bone replacement scaffolds. In one...
US20130124108 SYSTEM AND METHOD FOR DETERMINING THE ISOTOPIC ANATOMY OF ORGANIC AND VOLATILE MOLECULES  
A computer implemented system and method for determining the isotopic anatomy of molecules. The system receives a user identified molecule that is to be analyzed, makes an initial guess as to the...
US20130123781 TARGETING MICROBUBBLES  
This invention related to manufactured microbubbles, as well as methods of using manufactured microbubbles, for example, in medicinal applications. The invention pertains to the physical structure...
US20130122361 FLUORIDE ION ELECTROCHEMICAL CELL  
Electrochemical cells of the present invention are versatile and include primary and secondary cells useful for a range of important applications including use in portable electronic devices....
US20130121966 Generation of PSA-only producing mutant strain  
Provided is an isolated B. fragilis bacterial cell producing a native capsular polysaccharide A (PSA), wherein the cell is incapable of producing capsular polysaccharides PSB, PSC, PSD, PSE, PSF,...
US20130121633 SYSTEMS AND METHODS FOR TUNING A CAVITY  
The present disclosure describes an integrated opto-mechanical and electro-mechanical system. The opto-mechanical and electro-mechanical system can be made of photonic crystals configured to move...
US20130121359 INTEGRATED BROADBAND QUANTUM CASCADE LASER  
A broadband, integrated quantum cascade laser is disclosed, comprising ridge waveguide quantum cascade lasers formed by applying standard semiconductor process techniques to a monolithic structure...
8441633 Multiple-photon excitation light sheet illumination microscope  
An apparatus for and method of performing multi-photon light sheet microscopy (MP-LISH), combining multi-photon excited fluorescence with the orthogonal illumination of light sheet microscopy are...
8440970 Characterization of nanoscale structures using an ultrafast electron microscope  
The present invention relates to methods and systems for 4D ultrafast electron microscopy (UEM)—in situ imaging with ultrafast time resolution in TEM. Single electron imaging is used as a c...
8439160 Acoustic suppression systems and related methods  
An acoustic suppression system for absorbing and/or scattering acoustic energy comprising a plurality of acoustic targets in a containment is described, the acoustic targets configured to have...
US20130115656 ENGINEERED YEAST CELLS AND USES THEREOF  
The present application provides engineered yeast cells and uses thereof. In specific embodiments, the yeast cells have a mutation in the GAL2 gene. In specific embodiments, the yeast cells can be...
8435798 Applications and methods of operating a three-dimensional nano-electro-mechanical resonator and related devices  
Carbon nanofiber resonator devices, methods for use, and applications of said devices are disclosed. Carbon nanofiber resonator devices can be utilized in or as high Q resonators. Resonant...
US20130109977 UV IMAGING FOR INTRAOPERATIVE TUMOR DELINEATION  
A medical imaging system and method. A UV/visible camera uses a back illuminated silicon imaging detector to observe a surface of a brain of a human subject in vivo during brain surgery for...
8431208 Multilayered cellular metallic glass structures  
Multi-layered cellular metallic glass structures and methods of preparing the same are provided. In one embodiment, the cellular metallic glass structure includes at least one patterned metallic...
US20130103337 HIGH-RESOLUTION MASS SPECTROMETER AND METHODS FOR DETERMINING THE ISOTOPIC ANATOMY OF ORGANIC AND VOLATILE MOLECULES  
A mass spectrometer including an entrance slit, an energy filter, a momentum filter and a detector array, the entrance slit, energy filter and momentum filter being configured to provide molecular...
US20130102651 GENERAL COMPOSITION FRAMEWORK FOR LIGAND-CONTROLLED RNA REGULATORY SYSTEMS  
The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom....
US20130098141 LOCALIZED DEPOSITION OF POLYMER FILM ON NANOCANTILEVER CHEMICAL VAPOR SENSORS BY SURFACE-INITIATED ATOM TRANSFER RADICAL POLYMERIZATION  
Cantilever chemical vapor sensors that can be tailored to respond preferentially in frequency by controlling the location of deposition of an adsorbing layer. Cantilever chemical vapor sensor...
8429761 Photon induced near field electron microscope and biological imaging system  
A method of obtaining PINEM images includes providing femtosecond optical pulse, generating electron pulses, and directing the electron pulses towards a sample. The method also includes overlapping...
8426806 Differential mobility spectrometer with spatial ion detector and methods related thereto  
Differential mobility spectrometer with spatial ion detector and methods related thereto are disclosed. The use of one or more spatial detector within differential mobility spectrometry can provide...
8426159 Microfluidic chemostat  
A chemostat is described that includes a growth chamber having a plurality of compartments. Each of the compartments may be fluidly isolated from the rest of the growth chamber by one or more...
8425986 Composite nanostructure solid acid fuel cell electrodes via electrospray deposition  
The present invention provides a method of preparing a nanostructure material on a substrate. The method includes spraying an aqueous solution from a capillary to the substrate, wherein the aqueous...
8424809 Control of aerodynamic forces by variable wetted surface morphology  
Systems and methods for providing dynamic control to a vehicle in a dynamic fluid. The systems and methods of the invention relate to one or more morphable surfaces that can be controlled by a...
8424560 Multi-valve microfluidic devices and methods  
Multi-valve autoregulatory microfluidic devices and methods are described. The described devices and methods offer improved performance and new means of tuning autoregulatory effects in...
US20130097164 SYSTEMS AND METHODS FOR DISTRIBUTED DATA ANNOTATION  
Systems and methods for distributed data annotation in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a distributed data annotation server system...
US20130092549 PROTON EXCHANGE MEMBRANE ELECTROLYSIS USING WATER VAPOR AS A FEEDSTOCK  
A light-driven electrolytic cell that uses water vapor as the feedstock and that has no wires or connections whatsoever to an external electrical power source of any kind. In one embodiment, the...
US20130091591 ARTERY- AND VEIN-SPECIFIC PROTEINS AND USES THEREFOR  
Arterial and venous endothelial cells are molecularly distinct from the earliest stages of angiogenesis. This distinction is revealed by expression on arterial cells of a transmembrane ligand,...
US20130090319 METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES  
A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the...
D679646 Descent stage for mars rover  
8416400 Wavefront imaging sensor  
Embodiments of the present invention relate to a wavefront imaging sensor (WIS) comprising an aperture layer having an aperture, a light detector having a surface and a transparent layer between...
8415646 Production of MeV micro beams of protons for medical applications  
A proton beam guidance apparatus and a method of providing proton beams having sub-micron beam width and MeV energies. The apparatus is a structure having an enclosed channel that can reflect or...
8414911 Photochemical therapy to affect mechanical and/or chemical properties of body tissue  
The disclosure concerns altering the mechanical and/or chemical property of a body tissue, particularly an ocular tissue. In specific cases, it concerns altering or stabilizing the shape of the...
8414785 Methods for fabrication of microfluidic systems on printed circuit boards  
Methods for fabrication of microfluidic systems on printed circuit boards (PCB) are described. The PCB contains layers of insulating material and a layer or layers of metal buried within layers of...
US20130085398 BRAIN-MACHINE INTERFACE BASED ON PHOTONIC NEURAL PROBE ARRAYS  
Method and apparatus for illuminating and imaging tissue is provided. In one version, the method includes illuminating a volume of a tissue with photons from a three-dimensional array of optical...
8413019 Computer-implemented method for correcting transmission errors using linear programming  
A computer-implemented method for correcting transmission errors. According to the method, a transmitted vector corrupted by error can be recovered solving a linear program. The method has...
8411282 On-chip phase microscope/beam profiler based on differential interference contrast and/or surface plasmon assisted interference  
A differential interference contrast (DIC) determination device and method utilizes an illumination source, a layer having a pair of two apertures that receive illumination from the illumination...
US20130080861 ERASURE CODING SCHEME FOR DEADLINES  
Error correction coding for streaming communication is provided. A streaming problem is modeled as a non-multicast network problem with a nested receiver structure. Each packet in the streaming...
US20130075487 Atmospheric Condensate Collector and Electrospray Source  
An atmospheric condensate collector and electrospray source apparatus. The apparatus has a cooler having a surface with a sharp point. The cooler generates a condensate from ambient atmosphere...
US20130074898 THERMOELECTRIC COOLING SYSTEM UTILIZING THE THOMSON EFFECT  
Thermoelectric cooling systems are disclosed that utilize the Thomson effect. The disclosed systems can be used, for example, in cryogenic applications. In one aspect, a system is provided for...
US20130074313 Multilayered Cellular Metallic Glass Structures and Methods of Preparing the Same  
Multi-layered cellular metallic glass structures and methods of preparing the same are provided. In one embodiment, the cellular metallic glass structure includes at least one patterned metallic...