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Patents and Patent Applications from California Institute of Technology


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US20130033339 BIFURCATION-BASED ACOUSTIC SWITCH AND RECTIFIER  
A tunable frequency acoustic rectifier that is a granular crystal composed of a statically compressed one-dimensional array of particles in contact, containing a light mass defect near a boundary....
US20130032731 PRODUCTION OF MEV MICRO BEAMS OF PROTONS FOR MEDICAL APPLICATIONS  
A proton beam guidance apparatus and a method of providing proton beams having sub-micron beam width and MeV energies. The apparatus is a structure having an enclosed channel that can reflect or...
8370074 System and methods for predicting transmembrane domains in membrane proteins and mining the genome for recognizing G-protein coupled receptors  
The invention provides computer-implemented methods and apparatus implementing a hierarchical protocol using multiscale molecular dynamics and molecular modeling methods to predict the presence of...
8369594 Dynamic motion contrast and transverse flow estimation using optical coherence tomography  
The methods described herein are methods to ascertain motion contrast within optical coherence tomography data based upon phase variance. The phase variance contrast observes the nanometer scale...
8368051 Complementary barrier infrared detector (CBIRD)  
An infrared detector having a hole barrier region adjacent to one side of an absorber region, an electron barrier region adjacent to the other side of the absorber region, and a semiconductor...
8367815 Modular polynucleotides for ligand-controlled regulatory systems  
The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom....
8367386 Cytochrome P450 oxygenases  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent...
US20130028729 POWER GENERATION SYSTEMS AND METHODS  
A power generation system with a plurality of mechanical devices is described. Each mechanical device has energy-capturing blades and a hydraulic pump. A power generation arrangement remote of the...
US20130025814 INJECTION MOLDING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming magnetic metallic glasses rapidly into a net shape using a rapid capacitor discharge forming...
8362839 Cross-differential amplifier  
A cross-differential amplifier is provided. The cross-differential amplifier includes an inductor connected to a direct current power source at a first terminal. A first and second switch, such as...
8361982 Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell  
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be...
8361922 Organometallic ruthenium complexes and related methods for the preparation of tetra-substituted and other hindered olefins  
The invention relates to ruthenium alkylidene complexes having an N-heterocyclic carbene ligand comprising a 5-membered heterocyclic ring having a carbenic carbon atom and at least one nitrogen...
8361787 Method for expression of small RNA molecules within a cell  
The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA complexes....
8361738 Methods for quantitative target detection and related devices and systems  
Described herein is a method for detection of a target in a sample and related devices and systems.
8361250 Amorphous platinum-rich alloys  
According to embodiments of the present invention, an amorphous alloy includes at least Pt, P, Si and B as alloying elements, and has a Pt weight fraction of about 0.925 or greater. In some...
US20130023676 LIPHAGAL ENANTIOMERS AND THEIR DERIVATIVES AND PRECURSORS, AND ENANTIOSELECTIVE METHODS OF MAKING THE SAME  
Enantioenriched compositions of liphagal and its derivatives and precursors include more than 50 mol % of a first enantiomer based on the total amount of a first and a second enantiomer. A method...
US20130022578 METHODS AND SYSTEM FOR INTERFERING WITH VIABILITY OF BACTERIA AND RELATED COMPOUNDS AND COMPOSITIONS  
Provided herein are methods and systems for interfering with viability of bacteria and related compounds and compositions.
US20130020197 LED-BASED SCREENER FOR PHOTOELECTROCHEMICAL MATERIALS DISCOVERY  
An LED-based materials analysis apparatus that measures the photoelectrochemical response of materials to illumination. The apparatus uses an array of light sources such as a plurality of LEDs that...
8356763 Mechanical lysis arrangements and methods  
Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or...
US20130017432 NOVEL SEPARATORS FOR ELECTROCHEMICAL SYSTEMS  
In an aspect, the invention provides separator systems for electrochemical systems providing electronic, mechanical and chemical properties useful for a range of electrochemical storage and...
8355768 Micromachined neural probes  
A neural probe includes at least one shaft, at least one first electrode disposed on a first side of the at least one shaft, and at least one second electrode disposed on a second side of the at...
8354231 Methods and systems for detecting and/or sorting targets  
Provided herein are methods and systems for detecting and/or sorting targets in a sample based on the combined use of polynucleotide-encoded protein and substrate polynucleotides. The...
8354075 Streamline-based microfluidic device  
The present invention provides a streamline-based device and a method for using the device for continuous separation of particles including cells in biological fluids. The device includes a main...
US20130012701 QUATERNARY HETEROATOM CONTAINING COMPOUNDS  
A compound useful as a building block for the manufacture of various compounds is represented by Formula A or D. In Formula A and D, z is 0 or 1; Q is a heteroatom; R1 through R11 and Ra through Rf...
US20130012690 METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS  
The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and...
US20130011618 PHOTOCURABLE PERFLUOROPOLYETHERS FOR USE AS NOVEL MATERIALS IN MICROFLUIDIC DEVICES  
A functionalized photocurable perfluoropolyether is used as a material for fabricating a solvent-resistant microfluidic device. Such solvent-resistant microfluidic devices can be used to control...
8350625 Adaptive power amplifier  
A power amplifier circuit comprising a scalable power amplifier including an input and an output, and a plurality of activated amplifier elements operative to produce an output signal at the...
8350578 Wiring nanoscale sensors with nanomechanical resonators  
A system, device, method, and apparatus provide the ability to wire a voltage sensitive device to a nanoelectromechanical system (NEMS) resonator. A voltage sensitive device is configured to detect...
8348999 In-situ formation of a valve  
The present invention satisfies the long felt need for a more compact and durable valve which may be formed in situ. The present invention provides a self-deployable valve system, a method of...
US20130007264 Systems and Methods of Network Analysis and Characterization  
Systems and methods for characterizing networks are disclosed. In several embodiments, a network analyzer applies a network analysis to a network that replaces components of the network in a model...
US20130001222 FORMING OF FERROMAGNETIC METALLIC GLASS BY RAPID CAPACITOR DISCHARGE  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming magnetic metallic glasses rapidly into a net shape using a rapid capacitor discharge forming...
US20130001083 METHOD AND APPARATUS FOR ANALYSIS AND SORTING OF POLYNUCLEOTIDES BASED ON SIZE  
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.
US20130001067 METHOD AND SYSTEM FOR SPLITTING WATER WITH VISIBLE LIGHT  
A method of producing hydrogen includes providing a substrate having a plurality of nanoparticles disposed thereon and providing a source of electromagnetic radiation. The method also includes...
RE43896 Image and video indexing scheme for content analysis  
The present invention provides an image and video indexing scheme for content analysis. According to the invention, a database of images or videos is compressed. By examining patterns in the...
D673482 Mars rover  
8343744 Regio- and enantioselective alkane hydroxylation with modified cytochrome P450  
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
US20120329038 Multivolume Devices, Kits and Related Methods for quantification of Nucleic Acids and Other Analytes  
Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting...
US20120328834 MICROFABRICATED ELASTOMERIC VALVE AND PUMP SYSTEMS  
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion...
US20120326717 PARTIAL POLARIZATION TRANSFER FOR SINGLE-SCAN MAGNETIC RESONANCE SPECTROSCOPY AND IMAGING  
A method of measuring precessing magnetization includes providing a first site characterized by a first spin order and providing a second site. The method also includes transferring a portion of...
8340435 Method and system for object recognition search  
A method for object recognition using shape and color features of the object to be recognized. An adaptive architecture is used to recognize and adapt the shape and color features for moving...
8338552 Co-polymer films for sensors  
Embodiments include a sensor comprising a co-polymer, the co-polymer comprising a first monomer and a second monomer. For some embodiments, the first monomer is poly-4-vinyl pyridine, and the...
8338387 Small molecule stimulators of neuronal growth  
Provided herein are small molecule stimulators of neuronal growth, their preparation, and their use for treatment of neurological disorders. In one embodiment, provided herein are methods of...
8336387 Microfabricated implantable wireless pressure sensor for use in biomedical applications and pressure measurement and sensor implantation methods  
A variable capacitor, a microfabricated implantable pressure sensor including a variable capacitor and an inductor, and related pressure measurement and implantation methods. The inductor may have...
US20120322854 REGULATION OF MACROPHAGE ACTIVATION USING MIR-125B  
The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage...
US20120321245 SILICA-ON-SILICON WAVEGUIDES AND RELATED FABRICATION METHODS  
A method of manufacturing a waveguide eliminates a prior art reflow step and introduces certain new steps that permit fabricating of an ultra-low loss waveguide element on a silicon chip. The...
US20120320448 CHIP-BASED FREQUENCY COMB GENERATOR WITH MICROWAVE REPETITION RATE  
A frequency comb generator fabricated on a chip with elimination of a disadvantageous reflow process, includes an ultra-high Q disk resonator having a waveguide that is a part of a wedge structure...
US20120319893 DAMAGE PROXY MAP FROM INTERFEROMETRIC SYNTHETIC APERTURE RADAR COHERENCE  
A method, apparatus, and article of manufacture provide the ability to generate a damage proxy map. A master coherence map and a slave coherence map, for an area prior and subsequent to (including)...
US20120313073 NICKEL-BASED ELECTROCATALYTIC PHOTOELECTRODES  
A photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconductive material having a photocatalyst such as nickel or...
US20120312986 CHARACTERIZATION OF NANOSCALE STRUCTURES USING AN ULTRAFAST ELECTRON MICROSCOPE  
The present invention relates to methods and systems for 4D ultrafast electron microscopy (UEM)—in situ imaging with ultrafast time resolution in TEM. Single electron imaging is used as a c...
8331886 Dynamic scalable concurrent communication and multi-core receiver architecture  
An integrated multi-core RF device includes a common amplifier which outputs an amplified RF signal. A common transmission line is configured to supply the amplified RF signal to a plurality of...