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Patents and Patent Applications from California Institute of Technology


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US20140041727 HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION OF MATERIALS  
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated...
8649606 Methods and systems for generating saliency models through linear and/or nonlinear integration  
Methods and systems for generating saliency models are discussed. Saliency models can be applied to visual scenes to generate predictions on which locations in the visual scenes are fixation...
8648742 Systems and methods for acquiring and decoding signals using compressed sensing  
Systems and methods in accordance with embodiments of the invention utilize a CS architecture based on a sub-linear time recovery process (with reduced memory requirements). In several embodiments,...
8648288 Pixels, imagers and related fabrication methods  
Pixels, imagers and related fabrication methods are described. The described methods result in cross-talk reduction in imagers and related devices by generating depletion regions. The devices can...
US20140039129 SOLVENT-FREE ENYNE METATHESIS POLYMERIZATION  
The disclosure describes methods of metathesizing unsaturated organic compounds, each method comprising contacting at least one feedstock comprising at least one olefinic or acetylenic precursor...
US20140038271 METHODS FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS  
The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell (CTC),...
US20140038195 MULTIPLEXING AND QUANTIFICATION IN PCR WITH REDUCED HARDWARE AND REQUIREMENTS  
Methods and algorithms for a multiplexed single detection channel amplification process and quantification of generated amplicons is presented. Various mathematical approaches for quantifying and...
US20140036267 OPTICAL TECHNIQUE FOR CHEMICAL AND BIOCHEMICAL ANALYSIS  
Structures and methods are described for optical detection of physical, chemical and/or biological samples. An optical detection structure may include a LED source, multiple filters and single or...
US20140034607 IMPLANTABLE INTRAOCULAR PRESSURE DRAIN  
An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube...
US20140033787 FORMING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically farming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
8642352 Methods and systems for detection of stoichiometry by Förster resonance energy transfer  
Methods to detect stoichiometries of protein complexes and/or interactions between proteins based on detection and quantification of FRET and related systems and compositions.
8641912 Method for fabricating monolithic two-dimensional nanostructures  
A patterning method for the creation of two-dimensional nanowire structures. Nanowire patterning methods are used with lithographical patterning approaches to form patterns in a layer of epoxy and...
8640786 Percussive augmenter of rotary drills for operating as a rotary-hammer drill  
A percussive augmenter bit includes a connection shaft for mounting the bit onto a rotary drill. In a first modality, an actuator percussively drives the bit, and an electric slip-ring provides...
US20140031243 MULTIPLEX DETECTION OF MOLECULAR SPECIES IN CELLS BY SUPER-RESOLUTION IMAGING AND COMBINATORIAL LABELING  
Methods and systems are provided for creating molecular barcodes or indicia for cellular constituents within single cells and for resolving such barcodes or indicia with super-resolution...
US20140030819 NANOPILLAR FIELD-EFFECT AND JUNCTION TRANSISTORS WITH FUNCTIONALIZED GATE AND BASE ELECTRODES  
Systems and methods for molecular sensing are described. Molecular sensors are described which are based on field-effect or bipolar junction transistors. These transistors have a nanopillar with a...
US20140030559 LITHIUM ION FLUORIDE ELECTROCHEMICAL CELL  
Electrochemical cells of the present invention are versatile and include primary and secondary cells useful for a range of important applications including use in portable electronic devices....
US20140030437 ANTIMICROBIAL MATERIALS  
The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to...
US20140029893 METHODS AND SYSTEMS FOR DELAYING OPTICAL WAVES  
Coupled-resonator optical waveguides (CROW) can be used to control a speed of an optical signal. In particular, the coupling distance between the resonators can be adjusted to precisely control a...
US20140029163 NANO TRI-CARBON COMPOSITE SYSTEMS AND MANUFACTURE  
Nano-carbon material is described that combines the common and unique properties of spherical fullerenes, carbon nanotubes and graphene carbon allotropes to create an architecture that has unique...
US20140027681 n-TYPE DOPED PbTe AND PbSe ALLOYS FOR THERMOELECTRIC APPLICATIONS  
The present invention demonstrates that weak scattering of carriers leads to a high mobility and therefore helps achieve low electric resistivity with high Seebeck coefficient for a thermoelectric...
US20140027610 PRECISION CHARGE INJECTOR  
A method and circuit for injecting charge into a circuit node, comprising (a) resetting a capacitor's voltage through a first transistor; (b) after the resetting, pre-charging the capacitor through...
US20140026413 SINGLE-LAYER PCB MICROFLUIDICS  
A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal...
8637436 Integrated semiconductor bioarray  
A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are...
US20140025926 Scalable Room Temperature Quantum Information Processor  
A quantum information processor (QIP) may include a plurality of quantum registers, each quantum register containing at least one nuclear spin and at least one localized electronic spin. At least...
US20140024066 ANIMAL MODEL HAVING PHOTO-ACTIVATABLE MITOCHONDRIA  
An animal model includes a photo-activatable fluorescent protein that can conditionally label the mitochondria throughout the animal or in selective animal cells and tissues, allowing for effective...
US20140022350 METHOD AND DEVICE FOR HIGH-RESOLUTION IMAGING WHICH OBTAINS CAMERA POSE USING DEFOCUSING  
A method and device for high-resolution three-dimensional (3-D) Imaging which obtains camera pose using defocusing is disclosed. The device comprises a lens obstructed by a mask having two sets of...
US20140021034 SOLAR FUELS GENERATOR  
The solar fuels generator includes an ionically conductive separator between a gaseous first phase and a second phase. A photoanode uses one or more components of the first phase to generate...
US20140020794 SYSTEMS AND METHODS FOR IMPLEMENTING BULK METALLIC GLASS-BASED MACROSCALE COMPLIANT MECHANISMS  
Systems and methods in accordance with embodiments of the invention implement bulk metallic glass-based macroscale compliant mechanisms. In one embodiment, a bulk metallic glass-based macroscale...
8633432 Reflective focusing and transmissive projection device  
Embodiments of the present invention relate to a reflective focusing and transmissive projection device having a body, a set of reflective-focusing components and a light detector. The body has a...
8632244 In-service monitoring of steam pipe systems at high temperatures  
A system and method for monitoring the properties of a fluid, such as water, in a steam pipe without mechanically penetrating the wall of the pipe. The system uses a piezoelectric transducer to...
US20140018882 BRAIN REPAIR USING ELECTRICAL STIMULATION OF HEALTHY NODES  
A method and system of compensating for a damaged brain node is disclosed. The damaged node is determined by techniques such as fMRI or neural recording. A healthy node that can compensate for the...
US20140017748 MODIFIED ALCOHOL DEHYDROGENASES FOR THE PRODUCTION OF FUELS AND CHEMICALS  
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
US20140017234 ANTIBODIES TARGETING HIV ESCAPE MUTANTS  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) broadly neutralizing antibodies having improved potency and breadth for...
8628492 Implantable glaucoma drainage device  
An implantable glaucoma drainage device (GDD) system is disclosed. The GDD system comprises a microflow control system for controlling intraocular pressure, a protective capillary carrier tube...
8628426 Illusion generating system  
The system provides a tristable environment that effects reorientation of horizontal and vertical surfaces at a human scale. The system allows the engagement and disengagement of the effect via...
US20140012122 IMPLANTABLE VASCULAR SYSTEM BIOSENSOR WITH GROWN CAPILLARY BEDS AND USES THEREOF  
An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more...
US20140011958 PHOTONIC STRUCTURES FROM SELF ASSEMBLY OF BRUSH BLOCK COPOLYMERS AND POLYMER BLENDS  
The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary...
US20140011007 CARBON NANOTUBE FOAMS WITH CONTROLLABLE MECHANICAL PROPERTIES  
Syntheses of carbon nanotubes (CNT) are disclosed. The syntheses can take place on a thermally oxidized silicon surface placed inside a furnace prior to a reaction. The setup can have many...
US20140007991 TOUGH IRON-BASED BULK METALLIC GLASS ALLOYS  
A family of iron-based, phosphor-containing bulk metallic glasses having excellent processibitity and toughness, methods for forming such alloys, and processes for manufacturing articles therefrom...
8624769 Mixed linear/square-root encoded single slope ramp provides a fast, low noise analog to digital converter with very high linearity for focal plane arrays  
An analog-to-digital converter (ADC) converts pixel voltages from a CMOS image into a digital output. A voltage ramp generator generates a voltage ramp that has a linear first portion and a...
8623610 Chondroitin sulfate binding proteins and modulators thereof  
Chondroitin sulfate polysaccharides with defined sulfation patterns can be synthesized. These chondroitin polysaccharides can be used to identify chondroitin sulfate binding proteins. Further,...
US20140005416 SYNTHETIC TRANSTAGANOLIDE AND BASILIOLIDE PRODUCTS, DERIVATIVES THEREOF, AND SYNTHESIS METHODS THEREOF  
Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.
US20140005036 FUNCTIONAL N-HETEROCYCLES FOR SOLID-SUPPORTED CATALYSIS  
An efficient method for the preparation of backbone-substituted imidazolinium salts for use as N-heterocyclic carbene ligands, e.g., for organometallic catalysts is provided. These functionalized...
8619358 Electrically pumped extrinsic semiconductor optical amplifier with slot waveguide  
An optical amplifier on a silicon platform includes a first doped device layer and a second doped device layer. A gain medium is positioned between the first and second doped device layers. The...
8619126 Single-lens, single-sensor 3-D imaging device with a central aperture for obtaining camera position  
A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an...
8616328 Method and apparatus for wave generation and detection using tensegrity structures  
A tensegrity apparatus having multiple tensegrity units for the transmission of solitary waves with adjustable profiles into a material or structure, and the detection of such waves from a material...
US20130347135 ANIMAL MODEL FOR PARKINSON'S DISEASE  
An animal model for Parkinson's disease has a disrupted Mfn2 gene in dopaminergic neurons.
US20130346409 Systems and Methods for the Determining Annotator Performance in the Distributed Annotation of Source Data  
Systems and methods for determining annotator performance in the distributed annotation of source data in accordance embodiments of the invention are disclosed. In one embodiment of the invention,...
US20130346356 Systems and Methods for Labeling Source Data Using Confidence Labels  
Systems and methods for the annotation of source data using confidence labels in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining...
US20130345189 METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES  
A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the...