Patents and Patent Applications from California Institute of Technology


Match Document Document Title
9518034 Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof  
This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the...
9517610 Grippers based on opposing van der Waals adhesive pads  
Novel gripping structures based on van der Waals adhesive forces are disclosed. Pads covered with fibers can be activated in pairs by opposite forces, thereby enabling control of the adhesive...
US20160356923 Photonic Structures from Self Assembly of Brush Block Copolymers and Polymer Blends  
The invention provides a class of block copolymers having a plurality of chemically different blocks, at least a portion of which incorporating polymer side chain groups having a helical secondary...
US20160356773 METHODS AND SYSTEMS FOR MODULATING HORMONES AND RELATED METHODS, AGENTS AND COMPOSITIONS  
Provided herein are bitter taste receptor ligands, related agents, combinations, compositions, methods and systems for modulating release of a metabolic hormone in vitro and in vivo from cells of...
US20160355852 METHODS AND SYSTEMS FOR SULFIMIDATION OR SULFOXIMIDATION OF ORGANIC MOLECULES  
The disclosure generally relates to the fields of synthetic organic chemistry. In particular, the present disclosure relates to methods and systems for the imidation of sulfides.
US20160355799 POLYPEPTIDES HAVING CELLULASE ACTIVITY  
The present disclosure relates to CBH II chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
9512894 Tunable passive vibration suppressor  
An apparatus and method for vibration suppression using a granular particle chain. The granular particle chain is statically compressed and the end particles of the chain are attached to a payload...
9512863 Silicon alignment pins: an easy way to realize a wafer-to-wafer alignment  
A silicon alignment pin is used to align successive layers of components made in semiconductor chips and/or metallic components to make easier the assembly of devices having a layered structure....
9512000 Fabrication and self-aligned local functionalization of nanocups and various plasmonic nanostructures on flexible substrates for implantable and sensing applications  
Methods for fabricating flexible substrate nanostructured devices are disclosed. The nanostructures comprise nano-pillars and metallic bulbs or nano-apertures. The nanostructures can be...
US20160352286 SELF-CONTAINED LARGE SCALE COMPUTING PLATFORM  
A massively parallel computer system (MPCS) includes a multitude of tiles each adapted to include one or more processing/memory units, power generation unit, and associated circuitry. The tiles...
US20160352022 PARABOLIC DEPLOYABLE ANTENNA  
A deployable antenna is described. The antenna comprises a mesh attached to foldable ribs, a hub and a sub-reflector. The antenna can be stowed in a tight space for launching in space, and later...
US20160347776 BASE-CATALYZED SILYLATION OF TERMINAL OLEFINIC C-H BONDS  
The present invention is directed to a mild, efficient, and general direct C(sp2)-H bond silylation of terminal olefins. Various embodiments includes methods, each method comprising or consisting...
US20160346771 CRYSTALLINE GERMANOSILICATE MATERIALS OF NEW CIT-13 TOPOLOGY AND METHODS OF PREPARING THE SAME  
The present disclosure is directed to novel crystalline germanosilicate compositions and methods of producing the same. In particular, the crystalline germanosilicate compositions are...
US20160345556 POPULATION CONTROL USING ENGINEERED TRANSLOCATIONS  
Embodiments provided herein relate to systems for synthetically-engineered reciprocal chromosomal translocation for gene insertion into a population of organisms such as insects.
9507061 Amorphous metals and composites as mirrors and mirror assemblies  
A mirror or mirror assembly fabricated by molding, pressing, assembling, or depositing one or more bulk metal glass (BMG), bulk metal glass composite (BMGMC), or amorphous metal (AM) parts and...
9505615 Method for controlling microstructural arrangement of nominally-aligned arrays of carbon nanotubes  
A method for controlling the microstructural arrangement of nominally-aligned arrays of carbon nanotubes (CNTs) and a foam structure of CNTs are disclosed. The method includes a functionalization...
US20160344022 METAL HYDRIDE ALLOYS WITH IMPROVED RATE PERFORMANCE  
Methods of preparing improved metal hydride alloy materials are provided. The alloys include a mixture of at least four of vanadium, titanium, nickel, chromium, and iron. The alloy is processed by...
US20160341945 LASER-BASED FOURIER PTYCHOGRAPHIC IMAGING SYSTEMS AND METHODS  
Certain embodiments pertain to laser-based Fourier ptychographic (LFP) imaging systems, angle direction devices used in the LFP imaging systems, optical switches used in the LFP imaging systems,...
US20160340692 TARGETED GENE DELIVERY FOR DENDRITIC CELL VACCINATION  
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific...
US20160339423 INTEGRATED ACTIVE FLUX MICROFLUIDIC DEVICES AND METHODS  
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
9499903 Carbon nanotube foams with controllable mechanical properties  
Syntheses of carbon nanotubes (CNT) are disclosed. The syntheses can take place on a thermally oxidized silicon surface placed inside a furnace prior to a reaction. The setup can have many...
US20160336934 COUPLING INDUCTOR BASED HYBRID MILLIMETER-WAVE SWITCH  
A switch comprising a plurality of inductors and a plurality of shunt transistors is described. Each inductor can be electrically coupled between adjacent shunt transistors to form a distributed...
US20160336660 EFFICIENT ACTIVE MULTI-DRIVE RADIATOR  
An integrated Multi-Port Driven (MPD) antenna that can be driven at many points with different signals. An integrated MPD radiating source utilizing an 8-phase ring oscillator and eight power...
US20160336476 P-COMPENSATED AND P-DOPED SUPERLATTICE INFRARED DETECTORS  
Barrier infrared detectors configured to operate in the long-wave (LW) infrared regime are provided. The barrier infrared detector systems may be configured as pin, pbp, barrier and double...
US20160335156 ASYMMETRIC ERROR CORRECTION AND FLASH-MEMORY REWRITING USING POLAR CODES  
Techniques are disclosed for generating codes for representation of data in memory devices that may avoid the block erasure operation in changing data values. Data values comprising binary digits...
US20160333866 METALLIC WALL HALL THRUSTERS  
A Hall thruster apparatus having walls constructed from a conductive material, such as graphite, and having magnetic shielding of the walls from the ionized plasma has been demonstrated to operate...
US20160331868 LIGHT ADJUSTABLE INTRAOCULAR LENSES USING UPCONVERTING NANOPARTICLES AND NEAR INFRARED (NIR) LIGHT  
This disclosure relates compositions comprising upconverting nanocrystals and photoactive compositions and methods using these compositions to modify treat myopia and other ocular conditions. In...
US20160331800 BOTULINUM NEUROTOXIN-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING  
The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases...
US20160331227 EXTENDED DURATION OPTICAL COHERENCE TOMOGRAPHY (OCT) SYSTEM  
This disclosure relates to the field of Optical Coherence Tomography (OCT). This disclosure particularly relates to methods and systems for providing larger field of view OCT images. This...
9497379 Variable-illumination fourier ptychographic imaging devices, systems, and methods  
Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier...
9494781 Plane-projection multi-photon microscopy  
A novel method and system for conducting wide-field multi-photon microscopy through plane-projection are provided. It has been discovered that the limitations of conventional temporal-focusing...
9494715 Nanoscale plasmonic field-effect modulator  
A plasmonic device having a transparent conducting oxide (TCO) waveguide and a tunable voltage applied across the TCO and a metal layer for modulating an input optical signal.
9493833 Methods for preventing induced synthesis of proteasomes in human cells  
Methods and compositions for inhibiting Nrf1 activity are provided for enhancing apoptosis in mammalian cells. Apoptosis is enhanced in mammalian cells by co-inhibiting Nrf1 activity and...
9493826 Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes  
Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting...
9493799 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes  
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the...
9493549 Antibodies directed toward the HIV-1 GP120 CD4 binding site with increased potency and breadth  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid...
9488636 Using a field effect device for identifying translocating charge-tagged molecules in a nanopore sequencing device  
A detector apparatus includes a field-effect transistor configured to undergo a change in amplitude of a source-to-drain current when at least a portion of a charge-tagged molecule translocates...
9487551 Small molecule compounds that control mammal-pathogenic nematodes  
The present invention relates to methods of modifying nematode behavior using certain isolated modulator compounds. Also disclosed are methods of promoting or inhibiting reproduction in a nematode...
US20160322514 Solar Cells and Methods of Manufacturing Solar Cells Incorporating Effectively Transparent 3D Contacts  
Solar cells in accordance with a number of embodiments of the invention incorporate effectively transparent 3D contacts that redirect light incident on the contacts onto the photoabsorbing...
US20160320605 VARIABLE-ILLUMINATION FOURIER PTYCHOGRAPHIC IMAGING DEVICES, SYSTEMS, AND METHODS  
Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier...
US20160320595 APERTURE SCANNING FOURIER PTYCHOGRAPHIC IMAGING  
Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of...
US20160320531 CONFORMAL OPTICAL METASURFACES  
Structures for scattering light at multiple wavelengths are disclosed. Scattering elements are fabricated with different geometric dimensions and arrangements, to scatter or focus light at the the...
US20160320096 SPECTRALLY SELECTIVE SEMICONDUCTOR DIELECTRIC PHOTONIC SOLAR THERMAL ABSORBER  
A solar thermal absorber including a spectrally selective filter comprising a stack of dielectric layers and one or more semiconductor absorber layers. The dielectric layers are transparent to...
US20160319314 COMPOSITIONS AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS  
The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise...
US20160318020 MICROFABRICATED CROSSFLOW DEVICES AND METHODS  
This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion...
9485076 Dynamic polarization modulation and control  
A method for sending a data from an electromagnetic radiator by polarization modulation of an electromagnetic wave includes radiating from the radiator first and second electromagnetic waves...
9484543 Fabrication of anchored carbon nanotube array devices for integrated light collection and energy conversion  
A method of fabricating optical energy collection and conversion devices using carbon nanotubes (CNTs), and a method of anchoring CNT's into thin polymeric layers is disclosed. The basic method...
9482887 Optical phased array using guided resonance with backside reflectors  
Methods and systems for controlling the phase of electromagnetic waves are disclosed. A device can consist of a guided resonance grating layer, a spacer, and a reflector. A plurality of devices,...
9482886 Integrated light source independent linewidth reduction  
An integrated optical linewidth reduction system detects/estimates the phase noise of an incoming optical signal and subtracts the detected phase noise from the phase noise of the incoming signal....
9482796 Controllable planar optical focusing system  
An optical device has a first metasurface disposed over a substrate. A high-contrast pattern of the first metasurface is operable for modifying, over a first phase profile, a phase front of an...