Patents and Patent Applications from California Institute of Technology


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US20160144100 MICRO-NEEDLE DRUG DELIVERY SYSTEMS  
Generally, devices, systems and methods of using one or more needle(s) or micro-needle arrays are described in which a shift of fluid volume from a first expansion member position to a second...
US20160143940 VEHICLE FOR DELIVERING A COMPOUND TO A MUCOUS MEMBRANE AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
PSA is delivered to the host by outer membrane vesicles (OMVs), secretion structures that target bacterial molecules to host cells. Purified OMVs direct the in vitro differentiation of functional...
9349543 Nano tri-carbon composite systems and manufacture  
Nano-carbon material is described that combines the common and unique properties of spherical fullerenes, carbon nanotubes and graphene carbon allotropes to create an architecture that has unique...
9349520 Ferromagnetic cores of amorphous ferromagnetic metal alloys and electronic devices having the same  
Ferromagnetic cores made from amorphous glasses and methods of forming ferromagnetic cores from metallic glasses are provided. The method forms a magnetic core from a section of a series of...
9348949 Sound proof helmet  
Novel methods and systems for acoustic proofing are disclosed. A sound proof helmet can be designed by optimizing several layers of different materials, thickness, and physical properties. The...
9347815 Single-protein nanomechanical mass spectrometry in real time  
Methods and devices relating to measuring a landing position and mass of an analyte adsorbed to a nanomechanical resonator by resolving adsorbate-induced frequency shifts in at least two modes of...
US20160135697 PORTABLE ELECTRONIC HEMODYNAMIC SENSOR SYSTEMS  
Systems and methods are provided for extracting hemodynamic information, optionally employing portable electronic devices with optional User Interface (UI) features for system implementation. The...
9343494 Light guided pixel configured for emissions detection and comprising a guide layer with a wavelength selective filter material and a light detector layer  
A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the...
9342786 Method and system for parallel batch processing of data sets using Gaussian process with batch upper confidence bound  
A method and system for selecting a batch of input data from available input data for parallel evaluation by a function is disclosed. The function is modeled as drawn from a Gaussian process....
9341782 Methods and systems for delaying optical waves  
Coupled-resonator optical waveguides (CROW) can be used to control a speed of an optical signal. In particular, the coupling distance between the resonators can be adjusted to precisely control a...
9340765 Microfluidic chemostat  
A method to suppress biofilm formation in a growth chamber of a chemostat is described. The method includes the steps of adding a lysis agent to an isolated portion of the growth chamber, and...
9340416 Polynucleotides and related nanoassemblies, structures, arrangements, methods and systems  
A linker polynucleotide for attaching a nanomaterial to a polynucleotidic platform and related nanoassemblies, arrangements, structures, methods and systems.
9339945 Systems and methods for gravity-independent gripping and drilling  
Systems and methods for gravity independent gripping and drilling are described. The gripping device can also comprise a drill or sampling devices for drilling and/or sampling in microgravity...
9339027 Enhancement of electromagnetic freezing by stabilization and oscillation of biogenic magnetite particles  
Novel methods and systems for electromagnetic freezing are disclosed. An oscillating magnetic field can be applied in conjunction with a static magnetic field in order to align magnetic particles...
US20160133540 MULTI-LAYER PACKAGING SCHEME FOR IMPLANT ELECTRONICS  
The present invention provides a micropackaged device comprising: a substrate for securing a device with a corrosion barrier affixed to the substrate, wherein the corrosion barrier comprises a...
US20160131882 COMMON-MODE DIGITAL HOLOGRAPHIC MICROSCOPE  
A digital holographic microscope including a single mode fiber collimated light source which provides illumination for both the ‘science’ and ‘reference’ arms, a pair of microscope objectives...
US20160131640 MICROFLUIDIC DEVICE  
Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device...
US20160131564 Systems and Methods for Determining the Effective Toughness of a Material and for Implementing Materials Possessing Improved Effective Toughness Characteristics  
Systems and methods in accordance with embodiments of the invention determine the effective toughness of a given material, and also implement materials possessing improved effective toughness...
US20160131560 METHODS FOR PHENOTYPING OF INTACT BONES BY TISSUE CLEARING AND STAINING  
In various embodiments, the present application teaches methods and kits for clearing and optionally subsequently visualizing tissue containing bone. In some embodiments, the method includes...
US20160130581 TARGETING DOMAIN AND RELATED SIGNAL ACTIVATED MOLECULAR DELIVERY  
Provided herein are signal activatable molecular constructs for enzyme-assisted delivery of molecules and related components, such as a sensor domain, compositions, methods and systems.
9334544 Cellulase compositions having improved thermostability and synergy  
A variant Cel5a endoglucanase has increased thermostability, increased enzymatic activity and/or increased expression in a host, relative to wild type Cel5a. The improved variant Cel5a...
9334517 Endoglucanase having enhanced thermostability and activity  
A variant Cel5a endoglucanase has increased thermostability, increased enzymatic activity and/or increased expression in a host, relative to wild type Cel5a. The improved variant Cel5a...
9334367 Carrier nanoparticles and related compositions, methods and systems  
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment...
US20160128173 TOROIDAL PLASMA SYSTEMS  
A toroidal plasma is generated without voltage input. It can be produced using a pressurized water jet directed at a non-conductive, dielectric plate. Systems and methods employing the setup are...
US20160126404 GRAPHENE-BASED MULTI-JUNCTIONS FLEXIBLE SOLAR CELL  
This disclosure relates to structures for the conversion of light into energy. More specifically, the disclosure describes devices for conversion of light to electricity using photovoltaic cells...
US20160123958 APPARATUS AND METHODS FOR CONDUCTING ASSAYS AND HIGH THROUGHPUT SCREENING  
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and...
US20160123854 METHODS FOR PHENOTYPING OF INTACT WHOLE TISSUES  
In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and...
US20160122192 PRODUCING ZEOLITE SSZ-39 USING ISOMERIC MIXTURES OF ORGANIC STRUCTURE DIRECTING AGENTS  
The present disclosure is directed to producing zeolite structures, especially Zeolite SSZ-39, using organic structure directing agents (OSDAs). In particular, the OSDAs comprise isomeric mixtures...
US20160120920 COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS  
Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can...
US20160120917 COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS  
Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The subject in need...
US20160120916 COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS  
Some embodiments include probiotics for use in treatment of one or more autism spectrum disorder (ASD) or epilepsy in a subject in need thereof. The probiotics can comprise Bacteroides bacteria...
9331360 Fluoride ion battery electrolyte compositions  
A fluoride ion battery includes a substantially lithium-free anode and cathode. At least one of the anode or cathode contains fluorine, and a substantially lithium-free liquid electrolyte is used...
9329179 Mechanically induced trapping of molecular interactions  
The invention provides devices and methods for surface patterning the substrate of a microfluidic device, and for detection and analysis of interactions between molecules by mechanically trapping...
9328813 Systems and methods for implementing bulk metallic glass-based strain wave gears and strain wave gear components  
Bulk metallic glass-based strain wave gears and strain wave gear components. In one embodiment, a strain wave gear includes: a wave generator; a flexspline that itself includes a first set of gear...
US20160114322 PARALLELIZED SAMPLE HANDLING  
Provided herein are methods, compositions, and devices for the parallel handling of samples, such as cells or other biological samples. The methods, compositions, and devices are suited for...
9325282 Self-healing technique for high frequency circuits  
A self-healing monolithic integrated includes an electronic circuit having a plurality of transistors. At least one sensor is disposed within and electrically coupled to the electronic circuit and...
9324507 Systems and methods for implementing high-temperature tolerant supercapacitors  
Systems and methods in accordance with embodiments of the invention implement high-temperature tolerant supercapacitors. In one embodiment, a high-temperature tolerant super capacitor includes a...
9322039 Compositions and methods for producing benzylisoquinoline alkaloids  
The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise...
9322022 Inhibition of DNA2 in fanconi anemia  
Inhibition of DNA2 in Fanconi anemia (FA) cells remedies the over-resection of DNA, thereby stabilizing the FA cells. Inhibition of DNA2 in FA cells allows for safe treatment of cancers in FA...
9322007 Stable fungal Cel6 enzyme variants  
The disclosure provides variant Cel6a enzymes having increased thermostability, methods of making and using such polypeptides.
9322001 Cytochrome P450 oxygenases  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher...
US20160111620 METHODS AND DEVICES FOR CONTROLLING THERMAL CONDUCTIVITY AND THERMOELECTRIC POWER OF SEMICONDUCTOR NANOWIRES  
Methods and devices for controlling thermal conductivity and thermoelectric power of semiconductor nanowires are described. The thermal conductivity and the thermoelectric power are controlled...
US20160111619 HIGH PERFORMANCE HIGH TEMPERATURE THERMOELECTRIC COMPOSITES WITH METALLIC INCLUSIONS  
The present invention provides a composite thermoelectric material. The composite thermoelectric material can include a semiconductor material comprising a rare earth metal. The atomic percent of...
US20160111563 PHOTON AND CARRIER MANAGEMENT DESIGN FOR NONPLANAR THIN-FILM COPPER INDIUM GALLIUM DISELENIDE PHOTOVOLTAICS  
Photovoltaic structures are disclosed. The structures can comprise randomly or periodically structured layers, a dielectric layer to reduce back diffusion of charge carriers, and a metallic layer...
US20160109726 CONTACT LENS WITH METERED LIQUID SYSTEM  
A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are...
9317473 Scalable room temperature quantum information processor  
A quantum information processor (QIP) may include a plurality of quantum registers, each quantum register containing at least one nuclear spin and at least one localized electronic spin. At least...
9316586 Apparatus for thermal cycling  
This invention provides a system for performing PCR, and real time PCR in particular, with great speed and specificity. The system employs a heat block containing a liquid composition to rapidly...
9316545 Scanning measurement of Seebeck coefficient of a heated sample  
A novel scanning Seebeck coefficient measurement technique is disclosed utilizing a cold scanning thermocouple probe tip on heated bulk and thin film samples. The system measures variations in the...
9316329 Hydraulic high pressure valve controller using the in-situ pressure difference  
A hydraulic valve controller that uses an existing pressure differential as some or all of the power source for valve operation. In a high pressure environment, such as downhole in an oil or gas...
9315862 Aptamer regulated nucleic acids and uses thereof  
The invention relates to trans-acting ligand-responsive nucleic acids and uses thereof. In particular, a ligand responsive nucleic acid comprises an effector domain and an aptamer domain that is...