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Patents and Patent Applications from California Institute of Technology


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US20120263691 MODULAR APTAMER-REGULATED RIBOZYMES  
An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is...
US20120262809 THERMALLY-RESILIENT, BROADBAND OPTICAL ABSORBER FROM UV-TO-IR DERIVED FROM CARBON NANOSTRUCTURES AND METHOD OF MAKING THE SAME  
A monolithic optical absorber and methods of making same. The monolithic optical absorber uses an array of mutually aligned carbon nanotubes that are grown using a PECVD growth process and a...
US20120262721 Arbitrary Optical Waveform Generation Utilizing Optical Phase-Locked Loops  
This invention relates to opto-electronic systems using semiconductor lasers driven by optical phase-locked loops that control the laser's optical phase and frequency. Feedback control provides a...
US20120261578 SCANNING LASER INFRARED MOLECULAR SPECTROMETER  
An infrared laser spectrometer employs a laser and a thermoelectrically cooler detector. The spectrometer uses a monolithic ring mirror with a single aperture that serves to accept the input laser...
8290449 Equalization of third-order intermodulation products in wideband direct conversion receiver  
A feedforward error-compensated receiver for minimizing undesired odd-order nonlinear distortion products. The receiver includes a first receiver path configured to receive an input signal. The...
8288170 Uses of parylene membrane filters  
The invention provides parylene membrane filters, filter devices and methods of making them and using them in the mechanical separation of cells and particles by size. The provision of parylene...
US20120255338 SHEET FORMING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
8284833 Serial concatenation of interleaved convolutional codes forming turbo-like codes  
A serial concatenated coder includes an outer coder and an inner coder. The outer coder irregularly repeats bits in a data block according to a degree profile and scrambles the repeated bits. The...
8283438 Functionalized polymers using protected thiols  
A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided....
US20120251583 METHODS OF MAKING NUCLEIC ACID NANOSTRUCTURES  
The disclosure relates to methods and composition for generating nanoscale devices, systems, and enzyme factories based upon a nucleic acid nanostructure the can be designed to have a predetermined...
US20120250225 METHOD TO INCREASE THE CAPACITANCE OF ELECTROCHEMICAL CARBON NANOTUBE CAPACITORS BY CONFORMAL DEPOSITION OF NANOPARTICLES  
A method of increasing the area of carbon nanotubes used in fabricating capacitors is described. The method involves reacting carbon nanotubes with electrically conductive ions, molecules or...
US20120250027 Surface Wave Assisted Structures and Systems  
A surface wave assisted system having an aperture layer with a surface and an aperture, and a plurality of grooves around the aperture. The plurality of grooves is configured to generate an optical...
US20120249353 SYSTEMS AND METHODS FOR ACQUIRING AND DECODING SIGNALS USING COMPRESSED SENSING  
Systems and methods in accordance with embodiments of the invention utilize a CS architecture based on a sub-linear time recovery process (with reduced memory requirements). In several embodiments,...
US20120247545 GRAPHENE-BASED MULTI-JUNCTIONS FLEXIBLE SOLAR CELL  
This disclosure relates to structures for the conversion of light into energy. More specifically, the disclosure describes devices for conversion of light to electricity using photovoltaic cells...
8277846 Complexing agents for compositions containing inclusion complexes  
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
8277664 Extraction of anions from solutions and mixtures using hyperbranched macromolecules  
Hyperbranched macromolecules and methods are described for selectively filtering contaminants such as anions from water and non-aqueous solutions, particularly in the presence of competing...
8276851 Control of aerodynamic forces by variable wetted surface morphology  
Systems and methods for providing dynamic control to a vehicle in a dynamic fluid. The systems and methods of the invention relate to one or more morphable surfaces that can be controlled by a...
US20120241017 Microfluidic Check Valves With Enhanced Cracking Pressures and Methods of Making the Same  
Microfluidic normally closed check valves and methods of making and using the same are provided. The check valves include an orifice, an occluding portion, and one or more attachment members which...
8274021 Fully integrated temperature regulator for biochemical applications  
The invention is an integrated temperature regulator that can be fabricated using conventional semiconductor processing technology. The integrated temperature regulator can include a reaction...
8273574 Apparatus and methods for conducting assays and high throughput screening  
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and...
8273345 Targeted gene delivery to dendritic cells  
Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific...
US20120236378 METHOD AND APPARATUS FOR SIMULTANEOUS PROCESSING OF MULTIPLE FUNCTIONS  
Electronic logic gates that operate using N logic state levels, where N is greater than 2, and methods of operating such gates. The electronic logic gates operate according to truth tables. At...
US20120234393 APPARATUS FOR DETECTING TARGET MOLECULES AND RELATED METHODS  
An apparatus for analysis of a sample and in particular of a biological sample. The apparatus contains a microfluidic chip with dies, adapted to be selectively activated or deactivated by presence...
8268446 Photocurable perfluoropolyethers for use as novel materials in microfluidic devices  
The use of a photocurable perfluoropolyether (PFPE) material for fabricating a solvent-resistant PFPE-based microfluidic device, methods of flowing a material and performing a chemical reaction in...
US20120233100 Active Learing Decision Engines  
Systems and methods for active learning decision engines in accordance with embodiments of the invention are disclosed. In one embodiment of the invention, an active learning decision engine...
US20120232133 DELIVERY OF PROTEINS USING ADENO-ASSOCIATED VIRUS (AAV) VECTORS  
Disclosed herein are compositions, systems and methods for delivery of proteins of interest using adeno-associated virus (AAV) vectors.
US20120231961 METHODS AND SYSTEMS FOR SPORES DETECTION  
Provided herein are methods and systems for the detection of spores in a sample which comprise permeabilizing a protein-based spore coat with a protein degrading agent comprising a non-ionic...
US20120231893 ILLUSION GENERATING SYSTEM  
The system provides a tristable environment that effects reorientation of horizontal and vertical surfaces at a human scale. The system allows the engagement and disengagement of the effect via...
US20120231470 METHODS AND SYSTEMS ASSOCIATED WITH DETECTION OF FATTY ACID ELONGATION IN A CELL  
Methods and systems to identify compounds capable of altering a fatty acid elongation pathway and for identifying conditions under which fatty acids elongation can occur in a cell are described....
US20120231444 Microfabricated Crossflow Devices and Methods  
This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion...
US20120229388 METHOD AND APPARATUS FOR PREVENTING INCORRECT INPUT IN PORTABLE TERMINAL  
According to certain embodiments, a method and apparatus for preventing incorrect input in a portable terminal includes identifying an input character string and, among previously registered...
US20120228883 BEAM-FORMING CONCENTRATING SOLAR THERMAL ARRAY POWER SYSTEMS  
The present invention relates to concentrating solar-power systems and, more particularly, beam-forming concentrating solar thermal array power systems. A solar thermal array power system is...
US20120228475 Talbot Imaging Devices and Systems  
Talbot imaging systems comprising a Talbot element, a phase gradient generating device, a light detector, and a processor. The Talbot element repeats a Talbot image at a distance from the Talbot...
US20120223217 E-PETRI DISHES, DEVICES, AND SYSTEMS  
An e-Petri dish comprising a transparent layer having a specimen surface and a light detector configured to sample a sequence of sub-pixel shifted projection images of a specimen located on the...
US20120223214 Light Guided Pixel  
A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the...
8260428 Method and system for training a visual prosthesis  
A method for training a visual prosthesis includes presenting a non-visual reference stimulus corresponding to a reference image to a visual prosthesis patient. Training data sets are generated by...
8259306 Single-lens, single-aperture, single-sensor 3-D imaging device  
A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens having a substantially oblong aperture, a sensor operable for...
8258909 Foldable polymer-based coil structure and method for fabricating the same  
A foldable polymer-based coil structure and a method for fabricating the same are disclosed. The coil structure has metal wirings and interconnections between the wirings. The wirings and...
8258899 Nano-electro-mechanical systems switches  
NEMS (Nano-Electro-Mechanical Systems) apparatuses are described. By applying a static electric field, an arm or beam in a NEMS apparatus is made to bend so that one electrical conductor is made to...
8257666 Integrated active flux microfluidic devices and methods  
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
8252559 Methods and systems for selective fluorination of organic molecules  
A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for...
8252539 Microfabricated crossflow devices and methods  
A microfluidic device for analyzing and/or sorting biological materials (e.g., molecules such as polynucleotides and polypeptides, including proteins and enzymes; viruses and cells) and methods for...
US20120213250 MEASURING SEEBECK COEFFICIENT  
A high temperature Seebeck coefficient measurement apparatus and method with various features to minimize typical sources of errors is described. Common sources of temperature and voltage...
US20120212383 TRAVELLING WAVE DISTRIBUTED ACTIVE ANTENNA RADIATOR STRUCTURES, HIGH FREQUENCY POWER GENERATION AND QUASI-OPTICAL FILTERING  
An integrated distributed active radiator (DAR) device includes first and second conductors disposed adjacent to each other. The conductors define curves which close on themselves to within a...
US20120211644 LIGHT-FIELD PIXEL  
A light-field pixel for detecting a wavefront, the light-field pixel comprises an aperture layer, a light detector layer, and a processor. The aperture layer has a non-conventional aperture and a...
8247784 Switched ferroelectric plasma ionizer  
A novel ion source for ambient mass spectrometry (switched ferroelectric plasma ionizer or “SwiFerr”), which utilizes the ambient pressure plasma resulting from a sample of barium titanate [00...
8247769 Characterization of nanoscale structures using an ultrafast electron microscope  
The present invention relates to methods and systems for 4D ultrafast electron microscopy (UEM)—in situ imaging with ultrafast time resolution in TEM. Single electron imaging is used as a c...
8246569 Implantable intraocular pressure drain  
An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube...
US20120206188 SYSTEMS AND METHODS FOR DYNAMIC MOSFET BODY BIASING FOR LOW POWER, FAST RESPONSE VLSI APPLICATIONS  
Systems and methods in accordance with embodiments of the invention are disclosed that include MOSFET transistor operation by adjusting Vbs, or the voltage applied to the body terminal of the...
8245094 Rank modulation for flash memories  
We investigate a novel storage technology, Rank Modulation, for flash memories. In this scheme, a set of n cells stores information in the permutation induced by the different charge levels of the...