Patents and Patent Applications from California Institute of Technology


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9012189 Modified alcohol dehydrogenases for the production of fuels and chemicals  
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
9011330 Implantable vascular system biosensor with grown capillary beds and uses thereof  
An implantable biocompatible biosensor is described herein. The biosensor includes a chip layer including a plurality of holes fabricated vertically there through, a power source, one or more...
9010935 Systems and methods for noninvasive analysis of retinal health and function  
A method for noninvasive analysis of a retina includes exposing the retina to one or more first sets of at least three illumination light signals. The at least three illumination light signals...
US20150106071 METHODS AND SYSTEMS FOR COMPARING VERTICAL AXIS TURBINE ARRAYS AND PROVIDING CONFIGURATIONS THEREOF  
A method for providing potential flow elements including a vortex to capture rotation of a turbine, a dipole to capture a blockage effect of the turbine, a sink to capture extracted energy from...
US20150105552 SYNTHESIS OF CHIRAL ENAMINONES, THEIR DERIVATIVES, AND BIOACTIVITY STUDIES THEREOF  
This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the...
US20150104371 CATALYTIC AMMONIA SYNTHESIS BY TRANSITION METAL MOLECULAR COMPLEXES  
This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to catalysts and catalytic methods for reduction of molecular nitrogen. The molecular...
US20150104293 V-SHAPED ARRANGEMENTS OF TURBINES  
A V-shaped arrangement of turbines adapted to orient in such a manner that crosswind enters the arrangement in a direction that is substantially parallel to the axis bisecting the arrangement is...
US20150104191 AMPLIFICATION-FREE ELECTRO-OPTICAL OSCILLATOR  
An electro-optical oscillator includes, in part, a modulator, a signal splitter, N photodiodes with N being an integer greater than one, a signal combiner, and a filter. The modulator modulates an...
US20150101933 TRANSLOCATION AND NUCLEOTIDE READING MECHANISMS FOR SEQUENCING NANODEVICES  
By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are...
US20150101664 PROTECTING THE SURFACE OF A LIGHT ABSORBER IN A PHOTOANODE  
A photoanode includes a passivation layer on a light absorber. The passivation layer is more resistant to corrosion than the light absorber. The photoanode includes a surface modifying layer that...
9006195 Regulation of hematopoietic stem cell functions through microRNAs  
The present disclosure relates to regulation of functions of hematopoietic stem cells (HSCs) by delivering of miRNAs, including miR-125b, miR-126, and miR-155, to HSCs. For example, in some...
9006014 Fabrication of three-dimensional high surface area electrodes  
A method for fabricating three dimensional high surface electrodes is described. The methods including the steps: designing the pillars; selecting a material for the formation of the pillars;...
9005987 Methods for quantitative target detection and related devices and systems  
Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.
9005548 Methods for fabricating high aspect ratio probes and deforming high aspect ratio nanopillars and micropillars  
Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.
US20150099658 ANTI-GP41 ANTIBODY-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING  
The present application provides stable peptide-based anti-gp41 antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of...
9000167 Transition-metal-free silylation of aromatic compounds  
The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one...
8999896 Discovery and applications of the proteolytic function of N-terminal acetylation of cellular proteins  
Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also...
US20150094697 MEDICAMENT DELIVERY SYSTEMS  
Described herein are systems, devices, and methods for the delivery of substances to, or the sampling of substances from, a patient using a portable and preferably implantable device. The...
US20150093758 PSA CAPTURE AGENTS, COMPOSITIONS, METHODS AND PREPARATION THEREOF  
Disclosed herein are novel synthetic prostate specific antigen (PSA)-targeted capture agents that specifically bind PSA. In certain embodiments, these PSA capture agents are biligand or triligand...
US20150092808 CHIP-BASED LASER RESONATOR DEVICE FOR HIGHLY COHERENT LASER GENERATION  
A highly-coherent chip-based laser generating system includes a disk resonator incorporating a wedge structure fabricated from a silicon dioxide layer of a chip. The disk resonator is operable to...
8993262 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes  
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the...
8993236 Electromagnetic molecular sensors and methods of using same  
Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors,...
8992858 Microfluidic devices and methods of use  
A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a...
US20150087001 METHODS FOR PHENOTYPING OF INTACT WHOLE TISSUES  
In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and...
8989948 Systems and methods for automated vessel navigation using sea state prediction  
Systems and methods for sea state prediction and autonomous navigation in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a method of...
8987531 Syntheses of Z-olefin-containing lepidopteran insect pheromones  
The present invention is directed to methods of synthesizing insect pheromones, particularly lepidopteran insect pheromones, their precursors and derivatives from inexpensive, readily available...
8986542 Microfluidic separation device and method of making same  
A device and method for making a microfluidic separation device. A microfluidic separation device could include a microfluidic column having an inlet, the microfluidic column being configured to...
US20150079342 METHOD AND SYSTEM FOR GRAPHENE FORMATION  
A method of forming graphene includes placing a substrate in a processing chamber and introducing a cleaning gas including hydrogen and nitrogen into the processing chamber. The method also...
US20150079038 SELECTIVE RECOVERY  
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
US20150078999 CYCLIC PEPTIDES AS PROTEIN TARGETING AGENTS  
Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof,...
US20150078754 OPTICALLY BALANCED OPTO-ELECTRICAL OSCILLATOR  
An opto-electrical oscillator includes, in part, first and second optical phase modulators, a coupler, an optical-to-electrical signal conversion circuit, and a control circuit. The first optical...
US20150076361 PHOTON DETECTOR AND PROCESS FOR DETECTING A SINGLE PHOTON  
A photon detector article includes a photon detector configured to receive a primary waveform, the photon detector includes a multiplication region; a photon absorption region; a punch through...
US20150075744 SYSTEMS AND METHODS FOR FABRICATING STRUCTURES INCLUDING METALLIC GLASS-BASED MATERIALS USING LOW PRESSURE CASTING  
Systems and methods in accordance with embodiments of the invention fabricate objects including metallic glass-based materials using low-pressure casting techniques. In one embodiment, a method of...
8980581 Site-specific incorporation of amino acids into molecules  
The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified...
8980550 Methods for measuring samples using consumer electronic devices and systems  
Methods for measuring and analyzing biological or chemical samples using consumer electronic devices and systems are described. Moreover, an accessory to enable using devices such as cell phones...
8978807 Terrain traversing device having a wheel with microhooks  
A terrain traversing device is described. The device includes an annular rotor element with a plurality of co-planar microspine hooks arranged on the periphery of the annular rotor element. Each...
US20150073385 REMOTE RESERVOIR MICRONEEDLE DRUG DELIVERY SYSTEMS  
Transdermal drug delivery patch devices are described in which microneedle array insertion or application forces are decoupled or separated from drug delivery actuation or application forces....
8976507 Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles  
A method of increasing the area of carbon nanotubes used in fabricating capacitors is described. The method involves reacting carbon nanotubes with electrically conductive ions, molecules or...
8976269 Compressive sensing based bio-inspired shape feature detection CMOS imager  
A CMOS imager integrated circuit using compressive sensing and bio-inspired detection is presented which integrates novel functions and algorithms within a novel hardware architecture enabling...
8975922 Method and apparatus for simultaneous processing of multiple functions  
Electronic logic gates that operate using N logic state levels, where N is greater than 2, and methods of operating such gates. The electronic logic gates operate according to truth tables. At...
8975065 Meandering channel fluid device and method  
Methods and devices of performing reactions for which presence of light is desirable are provided. Biological or chemical materials such as algae are put in a chamber shaped as a meandering fluid...
8975063 Compositions and methods for producing benzylisoquinoline alkaloids  
The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise...
8974814 Layered drug delivery polymer monofilament fibers  
The present invention is directed generally to a layered polymeric monofilament fiber drug delivery device, where each layer of the device can contain a different polymer, drug, additive, or any...
US20150064396 METHOD FOR SELECTIVELY ANCHORING AND EXPOSING LARGE NUMBERS OF NANOSCALE STRUCTURES  
Methods for fastening nanoscale structures within an anchoring structure to form a nanostructure composite and nanostructure composites formed therefrom. A primary fluid layer is formed on an...
8971834 Digital and analog IM3 product compensation circuits for an RF receiver  
Third-order intermodulation products (IM3) are attenuated in RF receivers by providing a typical main signal path and a parallel auxiliary signal path in which the IM3 products are accentuated,...
8970671 Nondiffracting beam detection devices for three-dimensional imaging  
Embodiments of the present invention relate a nondiffracting beam detection module for generating three-dimensional image data that has a surface layer having a first surface and a light...
8969076 Method for expression of small RNA molecules within a cell  
The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA...
8968921 Fluoride ion electrochemical cell  
Electrochemical cells of the present invention are versatile and include primary and secondary cells useful for a range of important applications including use in portable electronic devices....
8968789 Sulfonic esters of metal oxides and methods of their use  
The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
8968714 Carrier nanoparticles and related compositions, methods and systems  
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment...