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Patents and Patent Applications from California Institute of Technology


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US20140096816 HETEROJUNCTION MICROWIRE ARRAY SEMICONDUCTOR DEVICES  
A heterojunction semiconductor device including an array of microstructures, each microstructure including a microwire of a first semiconductor material and a coating of a second semiconductor...
8694866 MDS array codes with optimal building  
MDS (maximum distance separable) array codes are widely used in storage systems to protect data against erasures. The rebuilding ratio problem is addressed and efficient parity codes are proposed....
8693973 670 GHz Schottky diode based subharmonic mixer with CPW circuits and 70 GHz IF  
A coplanar waveguide (CPW) based subharmonic mixer working at 670 GHz using GaAs Schottky diodes. One example of the mixer has a LO input, an RF input and an IF output. Another possible mixer has...
8691104 Nanotextured surfaces and related methods, systems, and uses  
A method of controlling wetting characteristics is described. Such method includes forming and configuring nanostructures on a surface where controlling of the wetting characteristics is desired....
8691010 Microfluidic protein crystallography  
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents...
8689556 Phase change material thermal power generator  
An energy producing device, for example a submersible vehicle for descending or ascending to different depths within water or ocean, is disclosed. The vehicle comprises a temperature-responsive...
US20140094612 IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS  
The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are wherein: M is ruthenium or...
US20140094607 TRANSITION-METAL-FREE SILYLATION OF AROMATIC COMPOUNDS  
The present invention describes chemical systems and methods for silylating aromatic organic substrates, said system comprising a mixture of (a) at least one organosilane and (b) at least one...
US20140094021 METHOD FOR PRODUCING GRAPHENE OXIDE WITH TUNABLE GAP  
A method of fabricating a graphene oxide material in which oxidation is confined within the graphene layer and that possesses a desired band gap is provided. The method allows specific band gap...
US20140093674 SYSTEMS AND METHODS IMPLEMENTING WEAR-RESISTANT COPPER-BASED MATERIALS  
Systems and methods in accordance with embodiments of the invention implement copper-based materials in applications where resistance to wear is desired. In one embodiment, a wear-resistant gear...
US20140093448 MOLECULAR SIEVES AND RELATED METHODS AND STRUCTURE DIRECTING AGENTS  
Method for preparing molecular sieves and molecular sieves obtained thereby are described. The method includes preparing a reaction mixture, comprising a structure directing agent, at least one...
US20140091256 TRANSITION-METAL FREE REDUCTIVE CLEAVAGE OF AROMATIC C-O, C-N, AND C-S BONDS BY ACTIVATED SILANES  
The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong...
8689083 Rate-compatible protograph LDPC codes  
Digital communication coding methods resulting in rate-compatible low density parity-check (LDPC) codes built from protographs. Described digital coding methods start with a desired code rate and...
8688065 Method to measure total noise temperature of a wireless receiver during operation  
An electromagnetic signal receiver and methods for determining the noise level and signal power in a signal of interest while the receiver is operating. In some embodiments, the signal of interest...
8686359 Characterization of nanoscale structures using an ultrafast electron microscope  
The present invention relates to methods and systems for 4D ultrafast electron microscopy (UEM)—in situ imaging with ultrafast time resolution in TEM. Single electron imaging is used as a...
8685727 Regulation of macrophage activation using miR-125b  
The present disclosure relates to regulation of macrophage activation by delivering of miRNAs, for example miR-125b or anti-miR-125b, to macrophages. For example, in some embodiments, macrophage...
US20140087359 METHODS AND DEVICES FOR SAMPLE LYSIS  
Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The...
US20140084160 PHOTON INDUCED NEAR FIELD ELECTRON MICROSCOPE AND BIOLOGICAL IMAGING SYSTEM  
A method of obtaining PINEM images includes providing femtosecond optical pulse, generating electron pulses, and directing the electron pulses towards a sample. The method also includes...
US20140083150 FORMING OF FERROMAGNETIC METALLIC GLASS BY RAPID CAPACITOR DISCHARGE  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming magnetic metallic glasses rapidly into a net shape using a rapid capacitor discharge forming...
8680637 Atomic layer deposition of chemical passivation layers and high performance anti-reflection coatings on back-illuminated detectors  
A back-illuminated silicon photodetector has a layer of Al2O3 deposited on a silicon oxide surface that receives electromagnetic radiation to be detected. The Al2O3 layer has an antireflection...
8680266 Metallocorroles  
Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes....
US20140080700 NANOSTRUCTURED PLATINUM ALLOYS FOR USE AS CATALYST MATERIALS  
A series of binary and ternary Pt-alloys, that promote the important reactions for catalysis at an alloy surface; oxygen reduction, hydrogen oxidation, and hydrogen and oxygen evolution. The first...
US20140080133 THERMALLY CONTROLLED CHAMBER WITH OPTICAL ACCESS FOR HIGH-PERFORMANCE PCR  
Novel methods and systems for polymerase chain reaction (PCR) are disclosed. A PCR device has a bottom heater layer, a central reacting layer, and a top heater layer. The central reacting layer...
US20140078261 METHOD AND APPARATUS FOR QUANTITATIVE 3-D IMAGING  
Described is a method and apparatus for obtaining additional information from an object and a method for surface imaging and three-dimensional imaging. Single lens, single aperture, single sensor...
US20140077991 ENHANCED BROADCAST EPHEMERIS FOR HIGH ACCURACY ASSISTED GPS POSITIONING  
Systems and methods for enhanced broadcast ephemeris are described. These systems and methods include the calculation and transmission of globally and locally optimized parameters of the broadcast...
US20140077799 INTEGRATED MAGNETIC SPECTROMETER FOR MULTIPLEXED BIOSENSING  
A magnetic spectrometer is integrated in a semiconductor substrate and provides high sensitivity without using an external magnet field. The spectrometer includes one or more highly stable on-chip...
8673645 Apparatus and methods for conducting assays and high throughput screening  
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and...
US20140073520 IMAGING CHROMOSOME STRUCTURES BY SUPER-RESOLUTION FISH WITH SINGLE-DYE LABELED OLIGONUCLEOTIDES  
Methods and systems are provided for creating molecular barcodes for DNA sequences of interest in chromosomes within single cells and for resolving such barcodes using super-resolution...
US20140073013 ULTRAFAST THERMAL CYCLER  
This disclosure provides thermal cyclers, systems, and methods of thermally cycling a sample.
US20140072993 SENSOR PROBE FOR BIO-SENSING AND CHEMICAL-SENSING APPLICATIONS  
The basic structure and functionality of a probe as disclosed herein allows for flexibly incorporating into the probe, various sensing elements for various sensing applications. Two example...
US20140072981 CYSTEINE HYDRAZIDE NICOTINAMIDE FOR GLYCOMICS AND GLYCOPROTEOMICS USES  
A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also...
US20140072534 NOVEL THERAPY FOR MULTIPLE SCLEROSIS USING VITAMIN D AND GUT BACTERIA  
A method for treating multiple sclerosis in a subject in need of such treatment is provided. The method includes administering a) polysaccharide A and b) vitamin D or a vitamin D metabolite to the...
US20140071249 COHERENT CAMERA  
A camera includes, in part, an optical signal source generating a frequency varying optical signal, a multitude of pixels arranged along rows and columns, an optical focusing element, and an...
US20140070286 NANO-PILLAR TRANSISTOR FABRICATION AND USE  
A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar...
8671315 Prognostic analysis system and methods of operation  
A prognostic analysis system and methods of operating the system are provided. In particular, a prognostic analysis system for the analysis of physical system health applicable to mechanical,...
8670471 Photonic crystal cavities and related devices and methods  
Photonic crystal cavities and related devices and methods are described. The described cavities can be used as lasers, photovoltaic sources, and single photon sources. The cavities can be both...
8669235 Modulation of innate immunity receptors' signaling by microRNAs miR-146a and miR-146b  
The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146...
US20140065994 METHOD TO MEASURE TOTAL NOISE TEMPERATURE OF A WIRELESS RECEIVER DURING OPERATION  
An electromagnetic signal receiver and methods for determining the noise level and signal power in a signal of interest while the receiver is operating. In some embodiments, the signal of interest...
US20140065653 MICROFLUIDIC LARGE SCALE INTEGRATION  
High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to...
US20140065132 DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER  
Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or...
US20140062805 Sensing Radiation Metrics Through Mode-Pickup Sensors  
A sensing structure includes an integrated circuit substrate, and a first sensor formed on or above the integrated circuit substrate adapted to detect a first part of an electromagnetic field in...
US20140061057 LIGHT-DRIVEN HYDROIODIC ACID SPLITTING FROM SEMICONDUCTIVE FUEL GENERATOR  
This disclosure relates to photovoltaic and photoelectrosynthetic cells, devices, methods of making and using the same.
US20140058506 3-COIL WIRELESS POWER TRANSFER SYSTEM FOR EYE IMPLANTS  
A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a...
US20140057416 SEMICONDUCTIVE MICRO- AND NANO-WIRE ARRAY MANUFACTURING  
The disclosure provides methods of manufacturing semiconductive structures using stamping and VLS techniques.
US20140057279 DEVICES AND METHODS FOR BIOLOGICAL SAMPLE-TO-ANSWER AND ANALYSIS  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or...
US20140057278 PEN-SHAPED DEVICE FOR BIOLOGICAL SAMPLE PREPARATION AND ANALYSIS  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a circular arrangement of containers, with a connecting structure such as a disk. Fluidics...
US20140057277 DEVICES AND METHODS FOR BIOLOGICAL SAMPLE PREPARATION  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or...
US20140057210 METHODS OF FABRICATION OF CARTRIDGES FOR BIOLOGICAL ANALYSIS  
Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber....
US20140055832 Integrated Two-Dimensional Planar Optical Phased Array  
An optical phased array includes, in part, a multitude of optical signal emitters and a multitude of optical signal phase/delay elements each associated with and disposed between a different pair...
US20140053531 METALLIC WALL HALL THRUSTERS  
A Hall thruster apparatus having walls constructed from a conductive material, such as graphite, and having magnetic shielding of the walls from the ionized plasma has been demonstrated to operate...