Patents and Patent Applications from California Institute of Technology


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8962241 Triggered molecular geometry based bioimaging probes  
The present embodiments relate to engineering imaging probes based on “triggered molecular geometry.” Upon detection of a molecular signal, nucleic acid hairpin monomers assemble an imageable...
8961716 Sheet forming of metallic glass by rapid capacitor discharge  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
8960325 Free-mass and interface configurations of hammering mechanisms  
The design of the free-mass in an ultrasonic driller/corer (USDC) has been refined in order to improve the performance and operational reliability of the system. In one embodiment, the...
US20150051411 SYNTHETIC TRANSTAGANOLIDE AND BASILIOLIDE PRODUCTS, DERIVATIVES THEREOF, AND SYNTHESIS METHODS THEREOF  
Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.
US20150050746 METHODS FOR FABRICATING HIGH ASPECT RATIO PROBES AND DEFORMING HIGH ASPECT RATIO NANOPILLARS AND MICROPILLARS  
Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.
US20150050701 CELLULASE COMPOSITIONS HAVING IMPROVED THERMOSTABILITY AND SYNERGY  
A variant Cel5a endoglucanase has increased thermostability, increased enzymatic activity and/or increased expression in a host, relative to wild type Cel5a. The improved variant Cel5a...
US20150050233 COMPOSITIONS CONTAINING INCLUSION COMPLEXES  
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
US20150047688 METHODS AND SYSTEMS FOR SELF-CLEANING OF PHOTOVOLTAIC PANELS  
Systems, devices, and methods are provided for self-cleaning photovoltaic panels that utilize piezo devices capable of causing vibrational movement in the panels.
US20150047683 In2Te3 Precipitates in Bulk Bi2Te3 for Thermoelectric Applications  
The present invention teaches a successful synthesis regime to grow highly oriented plate-like In2Te3 nanostructures inside bulk thermoelectric Bi2Te3 using a thermodynamically driven nucleation...
US20150047463 SYSTEMS AND METHODS FOR IMPLEMENTING BULK METALLIC GLASS-BASED MACROSCALE GEARS  
Systems and methods in accordance with embodiments of the invention implement bulk metallic glass-based macroscale gears. In one embodiment, a method of fabricating a bulk metallic glass-based...
8958270 Monolithic flexure pre-stressed ultrasonic horns  
A monolithic ultrasonic horn where the horn, backing, and pre-stress structures are combined in a single monolithic piece is disclosed. Pre-stress is applied by external flexure structures. The...
8956705 Ferroelectric liquid crystal (FLC) polymers  
A system having a ferroelectric liquid host material and a small amount of polymer additive is provided. In an embodiment, the polymer additive improves the physical characteristics of the system....
US20150044084 METHODS FOR FABRICATING GRADIENT ALLOY ARTICLES WITH MULTI-FUNCTIONAL PROPERTIES  
Systems and methods for fabricating multi-functional articles comprised of additively formed gradient materials are provided. The fabrication of multi-functional articles using the additive...
US20150042352 GENERATION AND ANALYSIS OF CHEMICAL COMPOUND LIBRARIES  
Various samples are generated on a substrate. The samples each includes or consists of one or more analytes. In some instances, the samples are generated through the use of gels or through vapor...
8951727 Translocation and nucleotide reading mechanisms for sequencing nanodevices  
By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are...
US20150038724 IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS  
The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are of the formula wherein: M...
US20150038455 HEPARAN SULFATE/HEPARIN MIMETICS WITH ANTI-CHEMOKINE AND ANTI-INFLAMMATORY ACTIVITY  
The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive...
US20150038436 TAILORED GLYCOPOLYMERS AS ANTICOAGULANT HEPARIN MIMETICS  
The present disclosure provides for methods and compositions comprising a series of synthetic glycopolymers. The disclosure also relates to a kit which is suitable for carrying out the inventive...
US20150038379 METHODS AND DEVICES FOR MICRO-ISOLATION, EXTRACTION, AND/OR ANALYSIS OF MICROSCALE COMPONENTS  
Provided herein are devices and methods for the micro-isolation of biological cellular material. A micro-isolation apparatus described can comprise a photomask that protects regions of interest...
US20150037782 ENHANCEMENT OF ELECTROMAGNETIC FREEZING BY STABILIZATION AND OSCILLATION OF BIOGENIC MAGNETITE PARTICLES  
Novel methods and systems for electromagnetic freezing are disclosed. An oscillating magnetic field can be applied in conjunction with a static magnetic field in order to align magnetic particles...
US20150036302 LONG-TERM PACKAGING FOR THE PROTECTION OF IMPLANT ELECTRONICS  
The present invention provides a micropackaged device comprising: a substrate for securing a device; a corrosion barrier affixed to said substrate; optionally at least one feedthrough disposed in...
US20150036038 APERTURE SCANNING FOURIER PTYCHOGRAPHIC IMAGING  
Certain aspects pertain to aperture-scanning Fourier ptychographic imaging devices comprising an aperture scanner that can generate an aperture at different locations at an intermediate plane of...
8949097 Methods and systems for comparing vertical axis turbine arrays and providing configurations thereof  
A method for providing potential flow elements including a vortex to capture rotation of a turbine, a dipole to capture a blockage effect of the turbine, a sink to capture extracted energy from...
8947800 Thermally-resilient, broadband optical absorber from UV-to-IR derived from carbon nanostructures and method of making the same  
A monolithic optical absorber and methods of making same. The monolithic optical absorber uses an array of mutually aligned carbon nanotubes that are grown using a PECVD growth process and a...
8946619 Talbot-illuminated imaging devices, systems, and methods for focal plane tuning  
A Talbot-illuminated imaging system for focal plane tuning, the device comprising a Talbot element, a tunable illumination source, a scanning mechanism, a light detector, and a processor. The...
8945471 Multipurpose analysis using second harmonic generating nanoprobes  
Second harmonic nanoprobes for multipurpose imaging of samples and a method of using such probes to monitor nucleotide sequencing in a Multi-SHG Detection Imaging (MSDI) modality and to monitor...
8945448 Method of manufacturing an implantable drug delivery system including an impedance pump  
Described herein are systems, devices, and methods for the delivery of substances to, or the sampling of substances from, a patient using a portable and preferably implantable device. The...
US20150031832 CARRIER NANOPARTICLES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment...
US20150031753 COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES  
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
US20150031460 GAMES HAVING BIOTECHNOLOGICAL CONTENT  
Systems and methods for use in playing biotic games having a biologically active material as a component. Various games that provide for one or more human players to interact with biologically...
US20150031116 INTEGRATED ACTIVE FLUX MICROFLUIDIC DEVICES AND METHODS  
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
US20150030529 ISOTHERMAL SYNTHESIS OF FUELS WITH REACTIVE OXIDES  
A method for converting thermal energy to chemical energy by reducing a reactive oxide substrate at a constant temperature under a first atmosphere with a lower oxygen partial pressure, and then...
US20150029579 CHIP-BASED FREQUENCY COMB GENERATOR WITH MICROWAVE REPETITION RATE  
A frequency comb generator fabricated on a chip with elimination of a disadvantageous reflow process, includes an ultra-high Q disk resonator having a waveguide that is a part of a wedge structure...
8940269 Methods and materials for the thermochemical production of hydrogen from water  
The present invention is directed to a method of thermochemical forming H2, O2, or a combination thereof from water, said method comprising the steps of contacting a composition comprising a...
US20150025126 METHOD OF PREPARING A SUPRAMOLECULAR COMPLEX CONTAINING A THERAPEUTIC AGENT AND A MULTI-DIMENSIONAL POLYMER NETWORK  
A method of preparing a supramolecular complex containing at least one therapeutic agent and a multi-dimensional polymer network is described. A supramolecular complex prepared by a method of the...
US20150024954 APTAMER REGULATED NUCLEIC ACIDS AND USES THEREOF  
The invention relates to aptamer-regulated, ligand-responsive nucleic acids, or “ampliSwitches,” and uses thereof. Particular embodiments include a ligand-responsive nucleic acid that comprises a...
US20150024481 SAMPLE PREPARATION DEVICES AND SYSTEMS  
Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also...
US20150020590 OPTOMECHANICAL ACCELEROMETER  
Technologies are generally described for operating and manufacturing optomechanical accelerometers. In some examples, an optomechanical accelerometer device is described that uses a cavity...
US20150020575 SYSTEM FOR ANALYZING A GAS MIXTURE INCLUDING AT LEAST ONE CHROMATOGRAPHY COLUMN  
A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas...
8936764 Nucleic acid amplification using microfluidic devices  
The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certain devices include a rotary microfluidic channel and a plurality...
US20150019179 METHODS FOR DESIGNING QUADRUPLE-RIDGED FLARED HORN ANTENNAS  
Novel methods and systems for antenna design are disclosed. A quadruple-ridged flared horn antenna can be designed based on geometry and frequency requirements. Automated optimization allows the...
US20150018781 SYSTEMS, DEVICES, AND METHODS FOR TOPICAL DRUG DELIVERY TO THE EYE  
Systems, devices, and methods are provided for delivering a therapeutic substance to the eye of a subject with an automated apparatus. The apparatus can resemble a pair of eyeglasses that can...
US20150018446 ORGANOCATALYZED PHOTOREDOX MEDIATED POLYMERIZATION USING VISIBLE LIGHT  
The present invention is directed to method of forming a polymer comprising exposing a mixture comprising an organic pre-polymer, an organic photoredox catalyst, and an organic initiator to a...
US20150018291 The Utility of Nematode Small Molecules  
The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. In one embodiment, the present invention provides a method of treating...
US20150018232 ELECTROCHEMICAL SUBSTRATE PATTERNING AND ANALYTE DETECTION ON A TWO-ELECTRODE PLATFORM  
A two-electrode detection system having target substrates including nucleic acids, proteins, and/or small molecules on specifically defined regions of a single surface. The spatial distribution of...
US20150017038 HELICALLY ACTUATED POSITIVE-DISPLACEMENT PUMP AND METHOD  
First and second structures are connected by helical fibers. The orientation between the first and second structures are changed, and by doing so, the positions of the helical fibers are...
US20150014885 SYSTEMS AND METHODS FOR ADDITIVE MANUFACTURING PROCESSES THAT STRATEGICALLY BUILDUP OBJECTS  
Systems and methods in accordance with embodiments of the invention implement additive manufacturing techniques that employ different sets of deposition characteristics and/or material formation...
8933143 On-demand photoinitiated polymerization  
Compositions and methods for adjustable lenses are provided. In some embodiments, the lenses contain a lens matrix material, a masking compound, and a prepolymer. The lens matrix material provides...
8932461 Microfluidic sieve valves  
Sieve valves for use in microfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing...
US20150011042 METHOD OF MAKING PHOTOVOLTAIC DEVICES INCORPORATING IMPROVED PNICTIDE SEMICONDUCTOR FILMS  
The present invention uses a treatment that involves an etching treatment that forms a pnictogen-rich region on the surface of a pnictide semiconductor film The region is very thin in many modes...