Patents and Patent Applications from California Institute of Technology


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US20150092808 CHIP-BASED LASER RESONATOR DEVICE FOR HIGHLY COHERENT LASER GENERATION  
A highly-coherent chip-based laser generating system includes a disk resonator incorporating a wedge structure fabricated from a silicon dioxide layer of a chip. The disk resonator is operable to...
8993262 In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes  
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the...
8993236 Electromagnetic molecular sensors and methods of using same  
Devices having an electromagnetic detector for the detection of analytes are disclosed. The devices include an electromagnetic detector, including effective inductance-change magnetic detectors,...
8992858 Microfluidic devices and methods of use  
A microfluidic device comprises pumps, valves, and fluid oscillation dampers. In a device employed for sorting, an entity is flowed by the pump along a flow channel through a detection region to a...
US20150087001 METHODS FOR PHENOTYPING OF INTACT WHOLE TISSUES  
In various embodiments, the present application teaches methods and compositions for tissue clearing in which whole organs and bodies are rendered macromolecule-permeable and...
8989948 Systems and methods for automated vessel navigation using sea state prediction  
Systems and methods for sea state prediction and autonomous navigation in accordance with embodiments of the invention are disclosed. One embodiment of the invention includes a method of...
8987531 Syntheses of Z-olefin-containing lepidopteran insect pheromones  
The present invention is directed to methods of synthesizing insect pheromones, particularly lepidopteran insect pheromones, their precursors and derivatives from inexpensive, readily available...
8986542 Microfluidic separation device and method of making same  
A device and method for making a microfluidic separation device. A microfluidic separation device could include a microfluidic column having an inlet, the microfluidic column being configured to...
US20150079342 METHOD AND SYSTEM FOR GRAPHENE FORMATION  
A method of forming graphene includes placing a substrate in a processing chamber and introducing a cleaning gas including hydrogen and nitrogen into the processing chamber. The method also...
US20150079038 SELECTIVE RECOVERY  
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
US20150078999 CYCLIC PEPTIDES AS PROTEIN TARGETING AGENTS  
Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof,...
US20150078754 OPTICALLY BALANCED OPTO-ELECTRICAL OSCILLATOR  
An opto-electrical oscillator includes, in part, first and second optical phase modulators, a coupler, an optical-to-electrical signal conversion circuit, and a control circuit. The first optical...
US20150076361 PHOTON DETECTOR AND PROCESS FOR DETECTING A SINGLE PHOTON  
A photon detector article includes a photon detector configured to receive a primary waveform, the photon detector includes a multiplication region; a photon absorption region; a punch through...
US20150075744 SYSTEMS AND METHODS FOR FABRICATING STRUCTURES INCLUDING METALLIC GLASS-BASED MATERIALS USING LOW PRESSURE CASTING  
Systems and methods in accordance with embodiments of the invention fabricate objects including metallic glass-based materials using low-pressure casting techniques. In one embodiment, a method of...
8980581 Site-specific incorporation of amino acids into molecules  
The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified...
8980550 Methods for measuring samples using consumer electronic devices and systems  
Methods for measuring and analyzing biological or chemical samples using consumer electronic devices and systems are described. Moreover, an accessory to enable using devices such as cell phones...
8978807 Terrain traversing device having a wheel with microhooks  
A terrain traversing device is described. The device includes an annular rotor element with a plurality of co-planar microspine hooks arranged on the periphery of the annular rotor element. Each...
US20150073385 REMOTE RESERVOIR MICRONEEDLE DRUG DELIVERY SYSTEMS  
Transdermal drug delivery patch devices are described in which microneedle array insertion or application forces are decoupled or separated from drug delivery actuation or application forces....
8976507 Method to increase the capacitance of electrochemical carbon nanotube capacitors by conformal deposition of nanoparticles  
A method of increasing the area of carbon nanotubes used in fabricating capacitors is described. The method involves reacting carbon nanotubes with electrically conductive ions, molecules or...
8976269 Compressive sensing based bio-inspired shape feature detection CMOS imager  
A CMOS imager integrated circuit using compressive sensing and bio-inspired detection is presented which integrates novel functions and algorithms within a novel hardware architecture enabling...
8975922 Method and apparatus for simultaneous processing of multiple functions  
Electronic logic gates that operate using N logic state levels, where N is greater than 2, and methods of operating such gates. The electronic logic gates operate according to truth tables. At...
8975065 Meandering channel fluid device and method  
Methods and devices of performing reactions for which presence of light is desirable are provided. Biological or chemical materials such as algae are put in a chamber shaped as a meandering fluid...
8975063 Compositions and methods for producing benzylisoquinoline alkaloids  
The present invention relates to host cells that produce compounds that are characterized as benzylisoquinolines, as well as select precursors and intermediates thereof. The host cells comprise...
8974814 Layered drug delivery polymer monofilament fibers  
The present invention is directed generally to a layered polymeric monofilament fiber drug delivery device, where each layer of the device can contain a different polymer, drug, additive, or any...
US20150064396 METHOD FOR SELECTIVELY ANCHORING AND EXPOSING LARGE NUMBERS OF NANOSCALE STRUCTURES  
Methods for fastening nanoscale structures within an anchoring structure to form a nanostructure composite and nanostructure composites formed therefrom. A primary fluid layer is formed on an...
8971834 Digital and analog IM3 product compensation circuits for an RF receiver  
Third-order intermodulation products (IM3) are attenuated in RF receivers by providing a typical main signal path and a parallel auxiliary signal path in which the IM3 products are accentuated,...
8970671 Nondiffracting beam detection devices for three-dimensional imaging  
Embodiments of the present invention relate a nondiffracting beam detection module for generating three-dimensional image data that has a surface layer having a first surface and a light...
8969076 Method for expression of small RNA molecules within a cell  
The invention provides methods and compositions for the expression of small RNA molecules within a cell using a lentiviral vector. The methods can be used to express doubles stranded RNA...
8968921 Fluoride ion electrochemical cell  
Electrochemical cells of the present invention are versatile and include primary and secondary cells useful for a range of important applications including use in portable electronic devices....
8968789 Sulfonic esters of metal oxides and methods of their use  
The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
8968714 Carrier nanoparticles and related compositions, methods and systems  
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment...
8968585 Methods of fabrication of cartridges for biological analysis  
Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber....
US20150057516 FULLY WIRELESS CONTINUOUSLY WEARABLE SENSOR FOR MEASUREMENT OF EYE FLUID  
Novel methods and systems for monitoring the health of an eye are disclosed. For example, a resonant circuit may be fabricated on a contact lens and this circuit may be coupled to a second circuit...
US20150057178 SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYS  
This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems,...
US20150056129 NEW METHODS AND MATERIALS FOR THE THERMOCHEMICAL PRODUCTION OF HYDROGEN FROM WATER  
The present disclosure is directed to methods of catalytically reducing carbon dioxide, each method comprising: contacting a composition comprising a spinel-type transition iron oxide with an...
US20150056109 SOLAR FUEL GENERATOR  
The disclosure provides conductive membranes for water splitting and solar fuel generation. The membranes comprise an embedded semiconductive/photoactive material and an oxygen or hydrogen...
US20150054979 VARIABLE-ILLUMINATION FOURIER PTYCHOGRAPHIC IMAGING DEVICES, SYSTEMS, AND METHODS  
Certain aspects pertain to Fourier ptychographic imaging systems, devices, and methods such as, for example, high NA Fourier ptychographic imaging systems and reflective-mode NA Fourier...
US20150053610 MIXED MATRIX MEMBRANES WITH EMBEDDED POLYMERIC PARTICLES AND NETWORKS AND RELATED COMPOSITIONS, METHODS, AND SYSTEMS  
Described herein are mixed matrix filtration membranes and related, compositions, methods and systems and in particular mixed matrix filtration membranes with an embedded polymer network and/or...
8963085 Photon induced near field electron microscope and biological imaging system  
A method of obtaining PINEM images includes providing femtosecond optical pulse, generating electron pulses, and directing the electron pulses towards a sample. The method also includes...
8962582 PKR activation via hybridization chain reaction  
The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease...
8962295 Stable, functional chimeric cellobiohydrolase class I enzymes  
The present disclosure relates to CBH I chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
8962241 Triggered molecular geometry based bioimaging probes  
The present embodiments relate to engineering imaging probes based on “triggered molecular geometry.” Upon detection of a molecular signal, nucleic acid hairpin monomers assemble an imageable...
8961716 Sheet forming of metallic glass by rapid capacitor discharge  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
8960325 Free-mass and interface configurations of hammering mechanisms  
The design of the free-mass in an ultrasonic driller/corer (USDC) has been refined in order to improve the performance and operational reliability of the system. In one embodiment, the...
US20150051411 SYNTHETIC TRANSTAGANOLIDE AND BASILIOLIDE PRODUCTS, DERIVATIVES THEREOF, AND SYNTHESIS METHODS THEREOF  
Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.
US20150050746 METHODS FOR FABRICATING HIGH ASPECT RATIO PROBES AND DEFORMING HIGH ASPECT RATIO NANOPILLARS AND MICROPILLARS  
Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.
US20150050701 CELLULASE COMPOSITIONS HAVING IMPROVED THERMOSTABILITY AND SYNERGY  
A variant Cel5a endoglucanase has increased thermostability, increased enzymatic activity and/or increased expression in a host, relative to wild type Cel5a. The improved variant Cel5a...
US20150050233 COMPOSITIONS CONTAINING INCLUSION COMPLEXES  
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
US20150047688 METHODS AND SYSTEMS FOR SELF-CLEANING OF PHOTOVOLTAIC PANELS  
Systems, devices, and methods are provided for self-cleaning photovoltaic panels that utilize piezo devices capable of causing vibrational movement in the panels.
US20150047683 In2Te3 Precipitates in Bulk Bi2Te3 for Thermoelectric Applications  
The present invention teaches a successful synthesis regime to grow highly oriented plate-like In2Te3 nanostructures inside bulk thermoelectric Bi2Te3 using a thermodynamically driven nucleation...