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Patents and Patent Applications from California Institute of Technology


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8603949 Libraries of optimized cytochrome P450 enzymes and the optimized P450 enzymes  
The present disclosure teaches that the recombination of homologous sequences of P450 enzymes, with the aid of SCHEMA to predict a resulting protein structure, is able to generate libraries of...
8603400 Nanostructured platinum alloys for use as catalyst materials  
A series of binary and ternary Pt-alloys, that promote the important reactions for catalysis at an alloy surface; oxygen reduction, hydrogen oxidation, and hydrogen and oxygen evolution. The first...
US20130324424 SCANNING DROP SENSOR  
Electrochemical experiments are performed on a collection of samples by suspending a drop of electrolyte solution between an electrochemical experiment probe and one of the samples that serves as a...
US20130323838 TRIGGERED RNAi  
The present application relates to methods and compositions for triggering RNAi. Triggered RNAi is highly versatile because the silencing targets are independent of the detection targets. In some...
US20130323716 SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYS  
This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems,...
US20130322892 Integrated Optical Phased Array  
An integrated optical phased array includes an input channel receiving an optical input signal, and a multitude of signal processing channels each adapted to supply an associated optical output...
US20130322807 Integrated Light Source Independent Linewidth Reduction  
An integrated optical linewidth reduction system detects/estimates the phase noise of an incoming optical signal and subtracts the detected phase noise from the phase noise of the incoming signal....
US20130322488 IMBEDDED CHIP FOR BATTERY APPLICATIONS  
Provided are methods, systems and devices for thermodynamically evaluating electrochemical systems and components thereof, including electrochemical cells such as batteries. The present systems and...
US20130319062 Electromagnetic Forming of Metallic Glasses Using a Capacitive Discharge and Magnetic Field  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
8600483 Mobile in vivo infra red data collection and diagnoses comparison system  
Described is a mobile in vivo infrared brain scan and analysis system. The system includes a data collection subsystem and a data analysis subsystem. The data collection subsystem is a helmet with...
8598137 Use of SAM68 for modulating signaling through the TNF receptor  
Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent...
8597577 Swept-frequency semiconductor laser coupled to microfabricated biomolecular sensor and methods related thereto  
An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described....
8597549 Two-photon or higher-order absorbing optical materials for generation of reactive species  
Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or...
US20130317648 BIOSLEEVE HUMAN-MACHINE INTERFACE  
Systems and methods for sensing human muscle action and gestures in order to control machines or robotic devices are disclosed. One exemplary system employs a tight fitting sleeve worn on a user...
US20130316366 EXPRESSION OF SECRETED AND CELL-SURFACE POLYPEPTIDES  
Some embodiments herein provide compositions and methods for expressing secreted and cell-surface-bound polypeptides in a single cell. In some embodiments, secreted and cell-surface polypeptide are...
8594600 Apparatus for the self healing of the gain of broadband receivers  
An integrated RF device includes at least one RF amplifier configured to be electrically coupled alternatively to a selected one of a RF signal input and a RF test source. A first mixer stage...
8593638 Split frequency sensing methods and systems  
Resonant sensors and molecule detection methods utilizing split frequency. Optical energy is introduced into a microcavity, such as a toroid-shaped or spherical microcavity. A portion of the...
8592215 Microfabricated crossflow devices and methods  
This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion...
8591758 Mechanochemical synthesis and thermoelectric properties of magnesium silicide and related alloys  
The present invention provides a method of making a substantially phase pure compound including a cation and an anion. The compound is made by mixing in a ball-milling device a first amount of the...
US20130310923 PERCUTANEOUS HEART VALVE DELIVERY SYSTEMS  
Embodiments described herein address the need for improved catheter devices for delivery, repositioning and/or percutaneous retrieval of the percutaneously implanted heart valves. One embodiment...
US20130310911 PARYLENE-BASED MICROELECTRODE ARRAY IMPLANT FOR SPINAL CORD STIMULATION  
An implantable electrode array assembly configured to apply electrical stimulation to the spinal cord. A substantially electrically nonconductive layer of the device has a first portion...
US20130309679 FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS  
The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for...
8586348 Lateral flow microfluidic assaying device and related method  
Provided herein is a microfluidic device and related method for controlling flow of different fluid components of a fluid. The microfluidic device comprises an input channel, focusing channel and...
8585630 Implantable intraocular pressure drain  
An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube...
US20130302633 THIN FILM BI-MATERIAL LATTICE STRUCTURES AND METHODS OF MAKING THE SAME  
A micro-scaled bi-material lattice structure includes a frame comprising a first material having a first coefficient of expansion and defining a plurality of unit cells. The bi-material lattice...
US20130301113 DEFORMABLE MIRRORS AND METHODS OF MAKING THE SAME  
A deformable mirror is configured to be deformed by surface-parallel actuation. In one embodiment, the deformable mirror includes a first piezoelectric active layer on a first surface of a...
US20130300834 SINGLE-LENS 3-D IMAGING DEVICE USING POLOARIZATION CODED APERTURE MASKS COMBINED WITH POLARIZATION SENSITIVE SENSOR  
A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, at least one polarization-coded aperture obstructing the lens, a...
US20130298985 MICROELECTRONIC STRUCTURES INCLUDING CUPROUS OXIDE SEMICONDUCTORS AND HAVING IMPROVED P-N HETEROJUNCTIONS  
The present invention provides strategies for making higher quality p-n heterojunctions that incorporate cuprous oxide and another material suitable for forming the heterojunction. When...
8582805 Synthetic foveal imaging technology  
Apparatuses and methods are disclosed that create a synthetic fovea in order to identify and highlight interesting portions of an image for further processing and rapid response. Synthetic foveal...
US20130297990 DISTRIBUTED REED-SOLOMON CODES FOR SIMPLE MULTIPLE ACCESS NETWORKS  
A computer-based distributed error correction scheme with an efficient decoding algorithm is disclosed. The efficiency of the corresponding decoding algorithm, based on standard single source...
US20130297019 HIGH-LEAD COUNT IMPLANT DEVICE AND METHOD OF MAKING THE SAME  
The invention provides chip packaging and processes for the assembly of retinal prosthesis devices. Advantageously, photo-patternable adhesive or epoxy such as photoresist is used as glue to attach...
US20130296511 LATENT, HIGH-ACTIVITY OLEFIN METATHESIS CATALYSTS CONTAINING AN N-HETEROCYCLIC CARBENE LIGAND  
The invention provides novel organometallic complexes useful as olefin metathesis catalysts. The complexes have an N-heterocyclic carbene ligand and a chelating carbene ligand associated with a...
US20130296491 Periodic Nanostructures From Self Assembled Wedge-Type Block-Copolymers  
The invention provides a class of wedge-type block copolymers having a plurality of chemically different blocks, at least a portion of which incorporates a wedge group-containing block providing...
US20130295653 INTEGRATED ACTIVE FLUX MICROFLUIDIC DEVICES AND METHODS  
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be...
US20130295615 METHOD FOR EXPRESSION OF SMALL ANTIVIRAL RNA MOLECULES WITH REDUCED CYTOTOXICITY WITHIN A CELL  
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector (FIG. 1A). Small interfering RNA (siRNA) can be...
US20130295321 Multilayered Cellular Metallic Glass Structures  
Multi-layered cellular metallic glass structures and methods of preparing the same are provided. In one embodiment, the cellular metallic glass structure includes at least one patterned metallic...
US20130294890 REVERSE BRAYTON CYCLE WITH BLADELESS TURBO COMPRESSOR FOR AUTOMOTIVE ENVIRONMENTAL COOLING  
An automotive cabin cooling system uses a bladeless turbocompressor driven by automobile engine exhaust to compress incoming ambient air. The compressed air is directed to an intercooler where it...
US20130294546 DOUBLE-SAMPLING RECEIVER WITH DYNAMIC OFFSET MODULATION FOR OPTICAL AND ELECTRICAL SIGNALING  
A receiver architecture is disclosed which employs an RC double-sampling front-end and dynamic offset modulation technique. A low-voltage double-sampling technique provides high power efficiency by...
US20130292658 ELECTRONIC DEVICES EMPLOYING ALIGNED ORGANIC POLYMERS  
The devices can be fabricated by a method that permits active polymer chains to be polymerized on the surface of an electrode such that the active polymer chains are aligned with one another. The...
8577607 GPS/INS sensor fusion using GPS wind up model  
A method of stabilizing an inertial navigation system (INS), includes the steps of: receiving data from an inertial navigation system; and receiving a finite number of carrier phase observables...
8576381 Method and apparatus for quantitative 3-D imaging  
Described is a method and apparatus for obtaining additional information from an object and a method for surface imaging and three-dimensional imaging. Single lens, single aperture, single sensor...
8575570 Simultaneous orthogonal light sheet microscopy and computed optical tomography  
An apparatus for and method of performing orthogonal light sheet microscopy (OLM) and computer optical tomography (COT) simultaneously in a single device are provided. The dual-mode imaging...
8574513 Single-layer PCB microfluidics  
A printed circuit board structure is coated with an encapsulant within which microfluidic channels have been formed. The microfluidic channels are formed by soldering fluidic connections to metal...
8574432 Integrated chromatography devices and systems for monitoring analytes in real time and methods for manufacturing the same  
Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple...
US20130288386 NANOSCALE CALORIMETER ON CHIP AND RELATED METHODS AND DEVICES  
An article comprising: an array of calorimeter devices, wherein the device comprises: at least one fluidic enclosure disposed on a microfluidic chip, wherein the fluidic enclosure is substantially...
US20130288324 CYTOCHROME P450 OXYGENASES  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent...
US20130285461 DEVICES AND METHODS FOR HARVESTING POWER FROM ARRAYS OF WIND TURBINES  
Variable frequency alternate current (VFAC) bus arrangements and systems using such VFAC bus arrangements are described, such as arrays of turbines. Such systems have a centrally located power...
US20130283957 ROBOTIC TWO-WHEELED VEHICLE  
A robotic two-wheeled vehicle comprising a connection body interposed between the two wheels are described. A drum can be coaxially located in a central region of the connection body and can...
8571615 Superconducting metallic glass transition-edge-sensors  
A superconducting metallic glass transition-edge sensor (MGTES) and a method for fabricating the MGTES are provided. A single-layer superconducting amorphous metal alloy is deposited on a...
8570649 Dual-mode raster point scanning/light sheet illumination microscope  
An apparatus for and method of performing light sheet microscopy (LISH) and light scanning microscopy (RAPS) in a single device are provided. The dual-mode imaging microscope allows for the use of...