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Patents and Patent Applications from California Institute of Technology


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8524875 Nucleic acids encoding SOX10 promoter and methods to isolate SOX10 expressing cells  
DNA enhancer sequences are provided for use in constructs to identify early stage embryonic cells. The enhancer sequences can be used in parallel with short-hairpin RNA in a vector construct for...
US20130225774 HIGH METATHESIS ACTIVITY RUTHENIUM AND OSMIUM METAL CARBENE COMPLEXES  
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic...
US20130225441 INTEGRATED SEMICONDUCTOR BIOARRAY  
A biosensor array, system and method for affinity based assays that are able to simultaneously obtain high quality measurements of the binding characteristics of multiple analytes, and that are...
US20130224632 NOVEL SEPARATORS FOR ELECTROCHEMICAL SYSTEMS  
Provided are separator systems for electrochemical systems providing electronic, mechanical and chemical properties useful for a variety of applications including electrochemical storage and...
US20130224550 Lithium-Based High Energy Density Flow Batteries  
Systems and methods in accordance with embodiments of the invention implement a lithium-based high energy density flow battery. In one embodiment, a lithium-based high energy density flow battery...
US20130222115 AUTONOMOUS AND CONTROLLABLE SYSTEMS OF SENSORS AND METHODS OF USING SUCH SYSTEMS  
An autonomous and controllable system of sensors and methods for using such a system of sensors are described.
US20130220729 METHOD AND APPARATUS FOR WAVE GENERATION AND DETECTION USING TENSEGRITY STRUCTURES  
A tensegrity apparatus having multiple tensegrity units for the transmission of solitary waves with adjustable profiles into a material or structure, and the detection of such waves from a material...
8518666 Site-specific incorporation of amino acids into molecules  
The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified...
8518193 Low density be-bearing bulk glassy alloys excluding late transition metals  
Low density Be-bearing bulk amorphous structural alloys with more than double the specific strength of conventional titanium alloys and methods of forming bulk articles from such alloys having...
US20130214760 MINIMAL POWER LATCH FOR SINGLE-SLOPE ADCs  
A latch circuit that uses two interoperating latches. The latch circuit has the beneficial feature that it switches only a single time during a measurement that uses a stair step or ramp function...
US20130213881 FILTRATION MEMBRANES AND RELATED COMPOSITIONS, METHODS AND SYSTEMS  
Described herein are filtration membranes and related, compositions, methods and systems and in particular filtration membranes with embedded polymeric micro/nanoparticles and related compositions,...
US20130213861 RADIAL OPPOSED MIGRATION AEROSOL CLASSIFIER WITH GROUNDED AEROSOL ENTRANCE AND EXIT  
A radial opposed migration classifier is provided for separating particles in a sample, introducing and removing the particles into and out of the classifier at the same potential. A sample passes...
US20130213860 OPPOSED MIGRATION AEROSOL CLASSIFIER GAS AND HEAT EXCHANGER  
A method is provided for changing a property of a sample. A sample, comprising particles suspended within a sample fluid, is introduced into a channel which comprises two walls that are permeable...
US20130213462 AXIALLY-INTEGRATED EPITAXIALLY-GROWN TANDEM WIRE ARRAYS  
A photoelectrode, methods of making and using, including systems for water-splitting are provided. The photoelectrode can be a semiconducting material having a photocatalyst such as nickel or...
8515131 Computation of intrinsic perceptual saliency in visual environments, and applications  
Detection of image salience in a visual display of an image. The image is analyzed at multiple spatial scales and over multiple feature channels to determine the likely salience of different...
8514268 Method and device for high-resolution three-dimensional imaging which obtains camera pose using defocusing  
A method and device for high-resolution three-dimensional (3-D) imaging which obtains camera pose using defocusing is disclosed. The device comprises a lens obstructed by a mask having two sets of...
8512722 Antimicrobial materials  
The disclosure provides methods and materials suitable for preparing coating layers on substrates. The coatings comprise quaternary amine groups and therefore impart anti-bacterial properties to...
US20130211012 Carrier Nanoparticles and Related Compositions, Methods and Systems  
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external...
US20130210646 HEMOMOSAIC: HIGH-THROUGHPUT TECHNIQUE FOR RARE CELL DETECTION IN LIQUID SAMPLES BY MASSIVELY MULTIPLEXED PCR IN A PHOTOLITHOGRAPHIC MATRIX  
Described microfluidic technology focused on: 1) direct integration of microfluidic devices with solidified liquid tissue samples, 2) subordination of architectural and operational principles of...
US20130210080 PC BOARD-BASED POLYMERASE CHAIN REACTION SYSTEMS, METHODS AND MATERIALS  
An apparatus for performing a Polymerase Chain Reaction (PCR) is disclosed. The apparatus comprises a PCR chamber for performing a Polymerase Chain Reaction and a printed circuit board (PCB)...
US20130210073 METHODS OF INCORPORATING AMINO ACID ANALOGS INTO PROTEINS  
The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-tRNA synthetase to charge the nonstandard amino acid to a modified tRNA,...
US20130209454 ANTI-HIV ANTIBODIES HAVING INCREASED POTENCY AND BREADTH  
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) antibodies having improved potency and breadth.
US20130209448 Carrier Nanoparticles and Related Compositions, Methods and Systems  
Carrier nanoparticles comprising a polymer containing a polyol coupled to a polymer containing a boronic acid, configured to present the polymer containing a boronic acid to an environment external...
US20130207639 WIRELESS VOLTAGE SENSING DEVICE  
A voltage sensing apparatus on a semiconductor substrate, including one or more inputs comprising metal contacts, an output comprising a laser transmitter, circuitry electrically connecting and...
8507307 Group IIB/VA semiconductors suitable for use in photovoltaic devices  
The present invention relates to devices, particularly photovoltaic devices, incorporating Group IIB/VA semiconductors such phosphides, arsenides, and/or antimonides of one or more of Zn and/or Cd....
8507204 Hybridization chain reaction amplification for in situ imaging  
The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that...
8506863 Method for adhering a microfluidic chip to a substrate  
A method for adhering two layers of materials is described. An additional layer of material deposited on one of the layers is used. The additional layer of material is perforated and undercut by...
US20130201058 PROCESSING SATELLITE DATA FOR SLANT TOTAL ELECTRON CONTENT MEASUREMENTS  
A method, system, and apparatus provide the ability to estimate ionospheric observables using space-borne observations. Space-borne global positioning system (GPS) data of ionospheric delay are...
8501923 Nucleic acid nanostructures  
The disclosure relates to methods and composition for generating nanoscale devices, systems, and enzyme factories based upon a nucleic acid nanostructure the can be designed to have a predetermined...
8499598 Electromagnetic forming of metallic glasses using a capacitive discharge and magnetic field  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
US20130197210 COMPLEXING AGENTS FOR COMPOSITIONS CONTAINING INCLUSION COMPLEXES  
The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the...
US20130197023 NEUROPROTECTION BY PHARMACOLOGICAL CHAPERONING OF NICOTINIC ACETYLCHOLINE RECEPTORS  
A method of ameliorating an endoplasmic reticulum (ER) stress response and/or unfolded protein response (UPR) in cells expressing nicotinic acetylcholine receptors (nAChRs) comprises contacting a...
US20130194048 ELECTROMECHANICAL OSCILLATORS, PARAMETRIC OSCILLATORS, AND TORSIONAL RESONATORS BASED ON PIEZORESISTIVE NANOWIRES  
Doubly-clamped nanowire electromechanical resonators that can be used to generate parametric oscillations and feedback self-sustained oscillations. The nanowire electromechanical resonators can be...
US20130193324 INTEGRATED TERAHERTZ IMAGING SYSTEMS  
A low-power 4×4-pixel THz camera with responsivity greater than 2.5 MV/W and sub-10 pW/√Hz NEP at 0.25 THz is integrated in 130 nm silicon without using either high-resistivity substrates or si...
8497364 Triggered RNAi  
The present application relates to methods and compositions for triggering RNAi. Triggered RNAi is highly versatile because the silencing targets are independent of the detection targets. In some...
8497071 Isolation of unknown rearranged T-cell receptors from single cells  
Disclosed herein are methods and materials for isolating and identifying T cell receptors from single cells. In some embodiments, genomic DNA from a single T cell is isolated using whole genome...
8496889 Microfluidic device for separating and sorting particles in a fluid medium  
A microfluidic device for separating emulsion solution into separate particles by passing the emulsion solution through a passive filter. The separated particles can then be sorted into separate...
8496077 Robotic two-wheeled vehicle  
A robotic two-wheeled vehicle comprising a connection body interposed between the two wheels are described. A drum can be coaxially located in a central region of the connection body and can...
US20130190504 Functionalized Polymers Using Protected Thiols  
A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided....
US20130189592 PART SOLID, PART FLUID AND FLOW ELECTROCHEMICAL CELLS INCLUDING METAL-AIR AND LI-AIR BATTERY SYSTEMS  
The invention provides part solid, part fluid and flow electrochemical cells, for example, metal-air and lithium-air batteries and three-dimensional electrode arrays for use in part solid, part...
US20130188194 BROADBAND, COMMON-PATH, INTERFEROMETRIC WAVEFRONT SENSOR  
Hybrid sensors comprising Shack-Hartmann Wavefront Sensor (S-HWFS) and Zernike Wavefront Sensor (Z-WFS) capabilities are presented. The hybrid sensor includes a Z-WFS optically arranged in-line...
US20130187094 GRANULAR CRYSTAL  
Granular crystals with one or more chains of particles are described. A geometry of at least one particle is chosen to provide highly nonlinear pulses having selected characteristics. Contact...
US20130185035 Systems and Methods of Analysis of Granular Elements  
Systems and methods are described for performing mechanical analysis of particulate systems by describing particle morphology of particles within the system using Non-Uniform Rational Basis Spline...
US20130184573 Intrinsic Frequency Hemodynamic Waveform Analysis  
Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies...
US20130184453 LINEAR CYCLODEXTRIN COPOLYMERS  
Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described....
US20130183712 METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION  
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations. The...
US20130183676 FILTERLESS TIME-DOMAIN DETECTION OF ONE OR MORE FLUOROPHORES  
A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes,...
US20130181312 SURFACE PASSIVATION BY QUANTUM EXCLUSION USING MULTIPLE LAYERS  
A semiconductor device has a multilayer doping to provide improved passivation by quantum exclusion. The multilayer doping includes at least two doped layers fabricated using MBE methods. The...
US20130180561 NANOCOMPOSITES WITH HIGH THERMOELECTRIC PERFORMANCE AND METHODS  
Disclosed herein include nanocomposites with improved thermoelectric performance. Also disclosed herein include methods of manufacturing and methods of using such nanocomposites.
8489260 Method and apparatus for powered descent guidance  
A method and apparatus for landing a spacecraft having thrusters with non-convex constraints is described. The method first computes a solution to a minimum error landing problem for a convexified...