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Patents and Patent Applications from California Institute of Technology


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US20130187094 GRANULAR CRYSTAL  
Granular crystals with one or more chains of particles are described. A geometry of at least one particle is chosen to provide highly nonlinear pulses having selected characteristics. Contact...
US20130185035 Systems and Methods of Analysis of Granular Elements  
Systems and methods are described for performing mechanical analysis of particulate systems by describing particle morphology of particles within the system using Non-Uniform Rational Basis Spline...
US20130184573 Intrinsic Frequency Hemodynamic Waveform Analysis  
Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies...
US20130184453 LINEAR CYCLODEXTRIN COPOLYMERS  
Linear cyclodextrin copolymers and linear oxidized cyclodextrin copolymers containing an unoxidized and/or an oxidized cyclodextrin moiety integrated into the polymer backbone are described....
US20130183712 METHOD AND COMPOSITIONS FOR THE DETECTION OF PROTEIN GLYCOSYLATION  
The invention provides methods and compositions for the rapid and sensitive detection of post-translationally modified proteins, and particularly of those with posttranslational glycosylations. The...
US20130183676 FILTERLESS TIME-DOMAIN DETECTION OF ONE OR MORE FLUOROPHORES  
A device and method are described in which the lifetime of a fluorescent species or fluorophores is detected in the absence of any optical filter. Based on the measured fluorescent lifetimes,...
US20130181312 SURFACE PASSIVATION BY QUANTUM EXCLUSION USING MULTIPLE LAYERS  
A semiconductor device has a multilayer doping to provide improved passivation by quantum exclusion. The multilayer doping includes at least two doped layers fabricated using MBE methods. The...
US20130180561 NANOCOMPOSITES WITH HIGH THERMOELECTRIC PERFORMANCE AND METHODS  
Disclosed herein include nanocomposites with improved thermoelectric performance. Also disclosed herein include methods of manufacturing and methods of using such nanocomposites.
8489260 Method and apparatus for powered descent guidance  
A method and apparatus for landing a spacecraft having thrusters with non-convex constraints is described. The method first computes a solution to a minimum error landing problem for a convexified...
8487623 Low field squid MRI devices, components and methods  
Low field SQUID MRI devices, components and methods are disclosed. They include a portable low field (SQUID)-based MRI instrument and a portable low field SQUID-based MRI system to be operated...
8487385 Uncooled IR detector arrays based on nanoelectromechanical systems  
We describe the use of a high-quality-factor torsional resonator of microscale dimensions. The resonator has a paddle that is supported by two nanoscale torsion rods made of a very low thermal...
8486636 Nucleic acid amplification using microfluidic devices  
The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certain devices include a rotary microfluidic channel and a plurality...
US20130178736 Noninvasive Systems for Blood Pressure Measurement in Arteries  
Hardware and software methodology are described for a non-invasive approach to blood pressure measurement in pulmonary artery and systemic arteries by using wall displacement and blood velocity...
US20130178722 Sharp Tip Carbon Nanotube Microneedle Devices and Their Fabrication  
Carbon nanotube needles and needle arrays are described in which the precursor pillars are etched by oxygen plasma treatment to provide tapered and/or sharp-tip needles. Processes, products by...
US20130178360 NICKEL-BASED ELECTROCATALYTIC PHOTOELECTRODES  
The disclosure provides methods and compositions comprising metal alloy powders. The disclosure also provides a photoelectrode, methods of making and using, including systems for water-splitting...
US20130175430 SPARSELY-BONDED CMOS HYBRID IMAGER  
A method and device for imaging or detecting electromagnetic radiation is provided. A device structure includes a first chip interconnected with a second chip. The first chip includes a detector...
US20130174896 TANDEM SOLAR CELL USING A SILICON MICROWIRE ARRAY AND AMORPHOUS SILICON PHOTOVOLTAIC LAYER  
This invention relates to photovoltaic cells, devices, methods of making and using the same.
US20130174495 DEPLOYABLE STRUCTURAL UNITS AND SYSTEMS  
Deployable units and systems made of deployable units are described. The units have a retractable brace transitioning from a retracted condition to a deployed condition through a gravity driven...
8482463 On-chip highly-efficient antennas using strong resonant coupling  
The invention relates to an antenna structure for coupling electromagnetic energy between a chip and an off-chip element, including a first resonant structure disposed on or in a chip. The first...
8481907 Mapping electrical crosstalk in pixelated sensor arrays  
The effects of inter pixel capacitance in a pixilated array may be measured by first resetting all pixels in the array to a first voltage, where a first image is read out, followed by resetting...
8481421 Functional anchors connecting graphene-like carbon to metal  
Functional linkers or anchors interconnecting graphene-like carbon, such as nanotubes or graphite sheets, with a conducting material such as a metal, are shown, together with related structures,...
8480978 Microfluidic fluid separator and related methods  
A microfluidic fluid separator for separating target components of a fluid by filtration is described. Methods for separating target components of a fluid by filtration and methods for processing...
8480923 Thermochemical synthesis of fuels for storing thermal energy  
The present invention provides a method for storing thermal energy, such as solar energy, as a fuel, by heating a reactive oxide substrate to a first temperature, such that the reactive oxide...
8480244 Methods and devices for directional radiative cooling thermal compensation  
A radiative thermal compensation system is described. An imaging arrangement located in an optical path between a surface to be thermally compensated (e.g., cooled) and one or more thermal sinks....
8480053 Method and apparatus for the mechanical actuation of valves in fluidic devices  
Mechanical actuation of valves in flexible fluidic structures allows for the regulation of fluid flow. In accordance with the disclosure herein, a fluidic structure is provided wherein mechanical...
8479538 Enhancing the optical characteristics of a gemstone  
Various embodiments described herein comprise a gemstone or other piece of jewelry, which incorporates one or more diffractive optical elements to enhance the fire displayed by the gemstone. In...
US20130167360 MICROMACHINED NEURAL PROBES  
A neural probe includes at least one shaft, at least one first electrode disposed on a first side of the at least one shaft, and at least one second electrode disposed on a second side of the at...
8478543 System and method for nucleic acid sequence design  
Described herein are systems and processes for designing the sequence of one or more interacting nucleic acid strands intended to adopt a target secondary structure at equilibrium. The target...
8476005 Microfluidic embedded polymer NEMS force sensors  
A method of screening one or more cells is described; the method includes: (i) providing one or more cells to a nanoelectromechanical system (NEMS) force sensor; (ii) applying at least one reagent...
US20130165762 SYSTEM AND METHOD FOR SENSING INTRAOCULAR PRESSURE  
Systems and methods of sensing intraocular pressure are described. In one embodiment, a miniaturized IOP monitoring system is provided using a nanophotonics-based implantable IOP sensor with remote...
US20130165661 IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS  
The present invention relates to novel metathesis catalysts with an imidazolidine-based ligand and to methods for making and using the same. The inventive catalysts are wherein: M is ruthenium or...
US20130165385 NEUROGENIN  
The invention relates to novel neurogenin proteins, nucleic acids and antibodies.
US20130164754 SAMPLE PREPARATION DEVICES AND SYSTEMS  
Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also...
8472032 Single-lens 3-D imaging device using polarization coded aperture masks combined with polarization sensitive sensor  
A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, at least one polarization-coded aperture obstructing the lens, a...
US20130158377 Drug Delivery and Substance Transfer Facilitated by Nano-Enhanced Device Having Aligned Carbon Nanotubes Protruding from Device Surface  
The present invention relates to a nano-enhanced device for substance transfer between the device and a tissue. The device comprises a substrate with substantially aligned carbon nanotubes anchored...
US20130155484 PLASMONIC MODULATOR INCORPORATING A SOLID-STATE PHASE CHANGE MATERIAL  
Systems and methods are provided for modulating light of a wavelength of interest. The modulator assembly includes a plasmonic layer that supports surface plasmon polaritons at the wavelength of...
US20130153811 METHOD OF MANUFACTURING THERMOELECTRIC MATERIAL, THERMOELECTRIC MATERIAL, AND THERMOELECTRIC CONVERSION ELEMENT  
The method of manufacturing the thermoelectric material including a plurality of phases that are phase-separated from a supersaturated solid solution includes: a process of performing a mechanical...
US20130150960 ACCOMMODATING INTRAOCULAR LENS  
Systems, devices, and methods are presented for a prosthetic injectable intraocular lens. The lenses can be made from silicone, fluorosilicone, and phenyl substituted silicone and be semipermeable...
US20130149714 BIO-DIAGNOSTIC TESTING SYSTEM AND METHODS  
An implantable diagnostic device in accordance with the present disclosure includes a probe assembly that can be implemented in a variety of ways. A few example implementations include: a needle...
US20130149351 POLYMER SCAFFOLDS AND THEIR USE IN THE TREATMENT OF VISION LOSS  
The present invention provides for scaffolds for growing RPE cells, comprising two or more biodegradable polymers. The present invention also provides for methods for creating a scaffold for...
US20130147919 Multi-View Difraction Grating Imaging With Two-Dimensional Displacement Measurement For Three-Dimensional Deformation Or Profile Output  
Hardware and software methodology is described for three-dimensional imaging in connection with optical transmission grating used to achieve a plurality of views of an area or entirety of an object...
US20130146998 SINGLE-BAND AND DUAL-BAND INFRARED DETECTORS  
Bias-switchable dual-band infrared detectors and methods of manufacturing such detectors are provided. The infrared detectors are based on a back-to-back heterojunction diode design, where the...
US20130144542 ANALYSIS DEVICE INCLUDING A MEMS AND/OR NEMS NETWORK  
A device for analyzing a fluid, including a layer including a plurality of sensors of MEMS and/or NEMS type, a layer including a mechanism controlling the sensor and for processing information...
US20130144399 3-DIMENSIONAL PARYLENE SCAFFOLD CAGE  
Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be r...
US20130143326 ULTRATHIN PARYLENE-C SEMIPERMEABLE MEMBRANES FOR BIOMEDICAL APPLICATIONS  
Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 μm to 5 μm thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be r...
US20130140270 IC-PROCESSED POLYMER NANO-LIQUID CHROMATOGRAPHY SYSTEM ON-A-CHIP AND METHOD OF MAKING IT  
Embodiments in accordance with the present invention relate to packed-column nano-liquid chromatography (nano-LC) systems integrated on-chip, and methods for producing and using same. The...
US20130140181 Apparatus and Methods for Conducting Assays and High Throughput Screening  
The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and...
US20130139964 AMORPHOUS METALS AND COMPOSITES AS MIRRORS AND MIRROR ASSEMBLIES  
A mirror or mirror assembly fabricated by molding, pressing, assembling, or depositing one or more bulk metal glass (BMG), bulk metal glass composite (BMGMC), or amorphous metal (AM) parts and...
US20130139931 Amorphous Platinum-Rich Alloys  
According to embodiments of the present invention, an amorphous alloy includes at least Pt, P, Si and B as alloying elements, and has a Pt weight fraction of about 0.925 or greater. In some...
8456645 Method and system for fast three-dimensional imaging using defocusing and feature recognition  
Described is a method and system for fast three-dimensional imaging using defocusing and feature recognition is disclosed. The method comprises acts of capturing a plurality of defocused images of...