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Patents and Patent Applications from California Institute of Technology


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US20140072981 CYSTEINE HYDRAZIDE NICOTINAMIDE FOR GLYCOMICS AND GLYCOPROTEOMICS USES  
A cysteine hydrazide nicotinamide (Cyhn) reagent designed for the enrichment of bacterial glycoproteins is provided. Methods for purification of free oligosaccharides and their analysis are also...
US20140072534 NOVEL THERAPY FOR MULTIPLE SCLEROSIS USING VITAMIN D AND GUT BACTERIA  
A method for treating multiple sclerosis in a subject in need of such treatment is provided. The method includes administering a) polysaccharide A and b) vitamin D or a vitamin D metabolite to the...
US20140071249 COHERENT CAMERA  
A camera includes, in part, an optical signal source generating a frequency varying optical signal, a multitude of pixels arranged along rows and columns, an optical focusing element, and an...
US20140070286 NANO-PILLAR TRANSISTOR FABRICATION AND USE  
A field effect nano-pillar transistor has a pillar shaped gate element incorporating a biomimitec portion that provides various advantages over prior art devices. The small size of the nano-pillar...
8671315 Prognostic analysis system and methods of operation  
A prognostic analysis system and methods of operating the system are provided. In particular, a prognostic analysis system for the analysis of physical system health applicable to mechanical,...
8670471 Photonic crystal cavities and related devices and methods  
Photonic crystal cavities and related devices and methods are described. The described cavities can be used as lasers, photovoltaic sources, and single photon sources. The cavities can be both...
8669235 Modulation of innate immunity receptors' signaling by microRNAs miR-146a and miR-146b  
The present disclosure relates to the finding that microRNA-146 plays a role modulating the innate immune response. Innate immunity receptor signaling can be modulated by delivery of microRNA-146...
US20140065994 METHOD TO MEASURE TOTAL NOISE TEMPERATURE OF A WIRELESS RECEIVER DURING OPERATION  
An electromagnetic signal receiver and methods for determining the noise level and signal power in a signal of interest while the receiver is operating. In some embodiments, the signal of interest...
US20140065653 MICROFLUIDIC LARGE SCALE INTEGRATION  
High-density microfluidic chips contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to...
US20140065132 DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER  
Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or...
US20140062805 Sensing Radiation Metrics Through Mode-Pickup Sensors  
A sensing structure includes an integrated circuit substrate, and a first sensor formed on or above the integrated circuit substrate adapted to detect a first part of an electromagnetic field in...
US20140061057 LIGHT-DRIVEN HYDROIODIC ACID SPLITTING FROM SEMICONDUCTIVE FUEL GENERATOR  
This disclosure relates to photovoltaic and photoelectrosynthetic cells, devices, methods of making and using the same.
US20140058506 3-COIL WIRELESS POWER TRANSFER SYSTEM FOR EYE IMPLANTS  
A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a...
US20140057416 SEMICONDUCTIVE MICRO- AND NANO-WIRE ARRAY MANUFACTURING  
The disclosure provides methods of manufacturing semiconductive structures using stamping and VLS techniques.
US20140057279 DEVICES AND METHODS FOR BIOLOGICAL SAMPLE-TO-ANSWER AND ANALYSIS  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or...
US20140057278 PEN-SHAPED DEVICE FOR BIOLOGICAL SAMPLE PREPARATION AND ANALYSIS  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a circular arrangement of containers, with a connecting structure such as a disk. Fluidics...
US20140057277 DEVICES AND METHODS FOR BIOLOGICAL SAMPLE PREPARATION  
Methods and devices for biological sample preparation and analysis are disclosed. A device may have a linear or circular arrangement of containers, with a connecting structure such as a bar or...
US20140057210 METHODS OF FABRICATION OF CARTRIDGES FOR BIOLOGICAL ANALYSIS  
Methods to fabricate reaction cartridges for biological sample preparation and analysis are disclosed. A cartridge may have a reaction chamber and openings to allow fluids to enter the chamber....
US20140055832 Integrated Two-Dimensional Planar Optical Phased Array  
An optical phased array includes, in part, a multitude of optical signal emitters and a multitude of optical signal phase/delay elements each associated with and disposed between a different pair...
US20140053531 METALLIC WALL HALL THRUSTERS  
A Hall thruster apparatus having walls constructed from a conductive material, such as graphite, and having magnetic shielding of the walls from the ionized plasma has been demonstrated to operate...
8660312 Quantitative differential interference contrast (DIC) devices for computed depth sectioning  
Embodiments of the present invention relate to a method for computing depth sectioning of an object using a quantitative differential interference contrast device having a wavefront sensor with...
8658976 Integrated terahertz imaging systems  
A low-power 4×4-pixel THz camera with responsivity greater than 2.5 MV/W and sub-10 pW/√Hz NEP at 0.25 THz is integrated in 130 nm silicon without using either high-resistivity substrates or...
8658780 Triggered covalent probes for imaging and silencing genetic expression  
The present invention relates to the use of cross-linking probes to covalently bind probes to nucleic acid targets. In some embodiments, the probe comprises an initiator region that is able to...
8658702 Soluble anion exchangers from hyperbranched macromolecules  
Novel macromolecules for filtering contaminants from water and non-aqueous solutions. Molecules such as polyethyleneimine (PEI) may be functionalized, cross-linked, and/or quaternized to improve...
8658368 Microfabricated crossflow devices and methods  
A microfluidic device is provided for analyzing or sorting biological materials, such as polynucleotides, polypeptides, proteins, enzymes, viruses and cells. The invention can be used for high...
8658367 Microfabricated crossflow devices and methods  
A microfluidic device is provided for analyzing or sorting biological materials, such as polynucleotides, polypeptides, proteins, enzymes, viruses and cells. The invention can be used for high...
8658309 Dissociating agents, formulations and methods providing enhanced solubility of fluorides  
The present invention provides compositions, formulations and methods providing for the effective dissolution of inorganic fluorides in solvents via incorporation of a dissociating agent...
8658112 Microfluidic chip capable of synthesizing radioactively labeled molecules on a scale suitable for human imaging with positron emission tomography  
Described herein are automated, integrated microfluidic device comprising a chemical reaction chip comprising for performing chemical reaction, a microscale column integrated with the chip and...
8657027 Single piezo-actuator rotary-hammering (SPaRH) drill  
A Single Piezo-Actuator Rotary-Hammering (SPaRH) Drill includes a horn actuator having high power piezoelectric materials and a flexure pre-stress to increase the actuators effectiveness. The...
US20140051817 HIGH METATHESIS ACTIVITY RUTHENIUM AND OSMIUM METAL CARBENE COMPLEXES  
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic...
US20140050374 USING RELEVANCE FEEDBACK IN FACE RECOGNITION  
Images are searched to locate faces that are the same as a query face. Images that include a face that is the same as the query face may be presented to a user as search result images. Images also...
US20140049823 BIREFRINGENT POLYMER BRUSH STRUCTURES FORMED BY SURFACE INITIATED RING-OPENING METATHESIS POLYMERIZATION  
The disclosure describes a polymer brush structure exhibiting birefringence, said polymer brush structure comprising a plurality of substantially parallel oriented polymers and characterized by a...
US20140048689 PIXELS, IMAGERS AND RELATED FABRICATION METHODS  
Pixels, imagers and related fabrication methods are described. The described methods result in cross-talk reduction in imagers and related devices by generating depletion regions. The devices can...
US20140048481 INTEGRATED CHROMATOGRAPHY DEVICES AND SYSTEMS FOR MONITORING ANALYTES IN REAL TIME AND METHODS FOR MANUFACTURING THE SAME  
Systems and methods for monitoring analytes in real time using integrated chromatography systems and devices. Integrated microfluidic liquid chromatography devices and systems include multiple...
US20140047888 SHEET FORMING OF METALLIC GLASS BY RAPID CAPACITOR DISCHARGE  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
D699618 Surface ornamentation for a diamond  
8656245 Method of error floor mitigation in low-density parity-check codes  
A digital communication decoding method for low-density parity-check coded messages. The decoding method decodes the low-density parity-check coded messages within a bipartite graph having check...
8653819 Technique for performing dielectric property measurements at microwave frequencies  
A method, system, apparatus, and computer readable medium has been provided with the ability to obtain a complex permittivity ∈ or a complex permeability μ of a sample in a cavity. One or more...
8653307 Liphagal enantiomers and their derivatives and precursors, and enantioselective methods of making the same  
Enantioenriched compositions of liphagal and its derivatives and precursors include more than 50 mol % of a first enantiomer based on the total amount of a first and a second enantiomer. A method...
US20140046202 NONINVASIVE SYSTEMS FOR AORTIC ANEURYSM EVALUATION  
Hardware and software methodology are described for non-invasive approaches to aortic aneurysm evaluation using ultrasound, microwave, and/or other radiofrequency (RF) techniques. Embodiments can...
US20140045261 SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES  
The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified...
US20140044885 METHOD AND SYSTEM FOR GRAPHENE FORMATION  
A method for forming graphene includes providing a substrate and subjecting the substrate to a reduced pressure environment. The method also includes providing a carrier gas and a carbon source...
US20140043188 GLOBAL POSITIONING SYSTEM RADIOMETRIC EVALUATION  
Methods and devices for the analysis of global positioning system (GPS) data are described. The methods and devices comprise several metrics to analyse GPS data, such as tracking coverage, signal...
US20140043132 FERROMAGNETIC CORES OF AMORPHOUS FERROMAGNETIC METAL ALLOYS AND ELECTRONIC DEVICES HAVING THE SAME  
Ferromagnetic cores made from amorphous glasses and methods of forming ferromagnetic cores from metallic glasses are provided. The method forms a magnetic core from a section of a series of...
US20140041727 HIGH THROUGHPUT SCREENING OF CRYSTALLIZATION OF MATERIALS  
High throughput screening of crystallization of a target material is accomplished by simultaneously introducing a solution of the target material into a plurality of chambers of a microfabricated...
8649606 Methods and systems for generating saliency models through linear and/or nonlinear integration  
Methods and systems for generating saliency models are discussed. Saliency models can be applied to visual scenes to generate predictions on which locations in the visual scenes are fixation...
8648742 Systems and methods for acquiring and decoding signals using compressed sensing  
Systems and methods in accordance with embodiments of the invention utilize a CS architecture based on a sub-linear time recovery process (with reduced memory requirements). In several...
8648288 Pixels, imagers and related fabrication methods  
Pixels, imagers and related fabrication methods are described. The described methods result in cross-talk reduction in imagers and related devices by generating depletion regions. The devices can...
US20140039129 SOLVENT-FREE ENYNE METATHESIS POLYMERIZATION  
The disclosure describes methods of metathesizing unsaturated organic compounds, each method comprising contacting at least one feedstock comprising at least one olefinic or acetylenic precursor...
US20140038271 METHODS FOR CANCER DETECTION, DIAGNOSIS AND PROGNOSIS  
The present invention provides a method for diagnosing cancer, predicting a disease outcome or response to therapy in a patient sample. The method involves isolating a circulating tumor cell...