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Patents and Patent Applications from California Institute of Technology


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8623610 Chondroitin sulfate binding proteins and modulators thereof  
Chondroitin sulfate polysaccharides with defined sulfation patterns can be synthesized. These chondroitin polysaccharides can be used to identify chondroitin sulfate binding proteins. Further,...
US20140005416 SYNTHETIC TRANSTAGANOLIDE AND BASILIOLIDE PRODUCTS, DERIVATIVES THEREOF, AND SYNTHESIS METHODS THEREOF  
Compounds represented by Formula I are provided that include synthetic transtaganolide and basiliolide products. Derivatives of these compounds and methods of synthesis are also provided.
US20140005036 FUNCTIONAL N-HETEROCYCLES FOR SOLID-SUPPORTED CATALYSIS  
An efficient method for the preparation of backbone-substituted imidazolinium salts for use as N-heterocyclic carbene ligands, e.g., for organometallic catalysts is provided. These functionalized...
8619358 Electrically pumped extrinsic semiconductor optical amplifier with slot waveguide  
An optical amplifier on a silicon platform includes a first doped device layer and a second doped device layer. A gain medium is positioned between the first and second doped device layers. The...
8619126 Single-lens, single-sensor 3-D imaging device with a central aperture for obtaining camera position  
A device and method for three-dimensional (3-D) imaging using a defocusing technique is disclosed. The device comprises a lens, a central aperture located along an optical axis for projecting an...
8616328 Method and apparatus for wave generation and detection using tensegrity structures  
A tensegrity apparatus having multiple tensegrity units for the transmission of solitary waves with adjustable profiles into a material or structure, and the detection of such waves from a material...
US20130347135 ANIMAL MODEL FOR PARKINSON'S DISEASE  
An animal model for Parkinson's disease has a disrupted Mfn2 gene in dopaminergic neurons.
US20130346409 Systems and Methods for the Determining Annotator Performance in the Distributed Annotation of Source Data  
Systems and methods for determining annotator performance in the distributed annotation of source data in accordance embodiments of the invention are disclosed. In one embodiment of the invention,...
US20130346356 Systems and Methods for Labeling Source Data Using Confidence Labels  
Systems and methods for the annotation of source data using confidence labels in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a method for determining...
US20130345189 METALLOINSERTOR COMPLEXES TARGETED TO DNA MISMATCHES  
A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the...
US20130343643 DETECTING FACIAL SIMILARITY BASED ON HUMAN PERCEPTION OF FACIAL SIMILARITY  
Similar faces may be determined within images based on human perception of facial similarity. The user may provide an image including a query face to which the user wishes to find faces that are...
US20130342835 TIME RESOLVED LASER RAMAN SPECTROSCOPY USING A SINGLE PHOTON AVALANCHE DIODE ARRAY  
A Raman spectrometer that employs a time-gated single photon avalanche diode array as a sensor is described. The spectrometer can also perform fluorescence spectroscopy and laser induced breakdown...
US20130342681 COMPRESSIVE SENSING BASED BIO-INSPIRED SHAPE FEATURE DETECTION CMOS IMAGER  
A CMOS imager integrated circuit using compressive sensing and bio-inspired detection is presented which integrates novel functions and algorithms within a novel hardware architecture enabling...
US20130342397 PHASED ANTENNA ARRAY FOR GLOBAL NAVIGATION SATELLITE SYSTEM SIGNALS  
Systems and methods for phased array antennas are described. Supports for phased array antennas can be constructed by 3D printing. The array elements and combiner network can be constructed by...
US20130341190 Method and Apparatus for Analysis and Sorting of Polynucleotides Based on Size  
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size.
8613816 Forming of ferromagnetic metallic glass by rapid capacitor discharge  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming magnetic metallic glasses rapidly into a net shape using a rapid capacitor discharge forming...
8613815 Sheet forming of metallic glass by rapid capacitor discharge  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
8613814 Forming of metallic glass by rapid capacitor discharge forging  
A forging apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming...
8613813 Forming of metallic glass by rapid capacitor discharge  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
US20130339287 METHOD AND SYSTEM FOR PARALLEL BATCH PROCESSING OF DATA SETS USING GAUSSIAN PROCESS WITH BATCH UPPER CONFIDENCE BOUND  
A method and system for selecting a batch of input data from available input data for parallel evaluation by a function is disclosed. The function is modeled as drawn from a Gaussian process....
US20130338803 ONLINE REAL TIME (ORT) COMPUTER BASED PREDICTION SYSTEM  
An online real-time (ORT) system and method implementing such system for real-time prediction of one of two actions or classes of action are described. Such actions are detected by corresponding...
8610589 Noise suppression techniques in high precision long-term frequency/timing measurements  
A frequency/timing measurement apparatus includes a reference source having a reference source output terminal. At least one target source has a target source output terminal. The at least one...
8609458 Method for producing graphene oxide with tunable gap  
A method of fabricating a graphene oxide material in which oxidation is confined within the graphene layer and that possesses a desired band gap is provided. The method allows specific band gap...
US20130328721 FEATURE IN ANTENNA PATTERN FOR POINTING AND ORIENTATION DETERMINATION  
Systems and methods for antenna pointing are disclosed. A transmit antenna system having an adjustable boresight transmits a signal exhibiting a far-field pattern including a feature (e.g. a...
US20130327645 DEVICES AND METHODS FOR SEQUENCING NUCLEIC ACIDS  
Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The...
US20130327392 Chemically Linked Colloidal Crystals and Methods Related Thereto  
Nanoparticles may be formed into colloidal crystals that are chemically linked to a substrate. In certain implementations, the nanoparticles are formed into a colloidal crystal on an initial...
8605516 Ultra-low-power variation-tolerant radiation-hardened cache design  
A random access memory (RAM) cell provides a control section and a storage section coupled to the storage section. The storage section includes complementary metal-oxide semiconductor (CMOS)...
8604176 Protein-responsive RNA control devices and uses thereof  
The invention described herein relates to an RNA-based control device that senses the presence and/or concentration of at least one protein ligand, preferably through its protein-binding aptamer...
8604141 High metathesis activity ruthenium and osmium metal carbene complexes  
Ruthenium and osmium carbene compounds that are stable in the presence of a variety of functional groups and can be used to catalyze olefin metathesis reactions on unstrained cyclic and acyclic...
8604098 On-demand photoinitiated polymerization  
Compositions and methods for adjustable lenses are provided. In some embodiments, the lenses contain a lens matrix material, a masking compound, and a prepolymer. The lens matrix material provides...
8603996 Modular aptamer-regulated ribozymes  
An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is...
8603949 Libraries of optimized cytochrome P450 enzymes and the optimized P450 enzymes  
The present disclosure teaches that the recombination of homologous sequences of P450 enzymes, with the aid of SCHEMA to predict a resulting protein structure, is able to generate libraries of...
8603400 Nanostructured platinum alloys for use as catalyst materials  
A series of binary and ternary Pt-alloys, that promote the important reactions for catalysis at an alloy surface; oxygen reduction, hydrogen oxidation, and hydrogen and oxygen evolution. The first...
US20130324424 SCANNING DROP SENSOR  
Electrochemical experiments are performed on a collection of samples by suspending a drop of electrolyte solution between an electrochemical experiment probe and one of the samples that serves as a...
US20130323838 TRIGGERED RNAi  
The present application relates to methods and compositions for triggering RNAi. Triggered RNAi is highly versatile because the silencing targets are independent of the detection targets. In some...
US20130323716 SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYS  
This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems,...
US20130322892 Integrated Optical Phased Array  
An integrated optical phased array includes an input channel receiving an optical input signal, and a multitude of signal processing channels each adapted to supply an associated optical output...
US20130322807 Integrated Light Source Independent Linewidth Reduction  
An integrated optical linewidth reduction system detects/estimates the phase noise of an incoming optical signal and subtracts the detected phase noise from the phase noise of the incoming signal....
US20130322488 IMBEDDED CHIP FOR BATTERY APPLICATIONS  
Provided are methods, systems and devices for thermodynamically evaluating electrochemical systems and components thereof, including electrochemical cells such as batteries. The present systems and...
US20130319062 Electromagnetic Forming of Metallic Glasses Using a Capacitive Discharge and Magnetic Field  
An apparatus and method of uniformly heating, rheologically softening, and thermoplastically forming metallic glasses rapidly into a net shape using a rapid capacitor discharge forming (RCDF) tool...
8600483 Mobile in vivo infra red data collection and diagnoses comparison system  
Described is a mobile in vivo infrared brain scan and analysis system. The system includes a data collection subsystem and a data analysis subsystem. The data collection subsystem is a helmet with...
8598137 Use of SAM68 for modulating signaling through the TNF receptor  
Sam68 plays a role in TNF-dependent signaling, including NF-kB signaling and extrinsic activation of apoptosis. In some embodiments, inhibitors of Sam68 are administered to inhibit TNF-dependent...
8597577 Swept-frequency semiconductor laser coupled to microfabricated biomolecular sensor and methods related thereto  
An optoelectronic swept-frequency semiconductor laser coupled to a microfabricated optical biomolecular sensor with integrated resonator and waveguide and methods related thereto are described....
8597549 Two-photon or higher-order absorbing optical materials for generation of reactive species  
Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or...
US20130317648 BIOSLEEVE HUMAN-MACHINE INTERFACE  
Systems and methods for sensing human muscle action and gestures in order to control machines or robotic devices are disclosed. One exemplary system employs a tight fitting sleeve worn on a user...
US20130316366 EXPRESSION OF SECRETED AND CELL-SURFACE POLYPEPTIDES  
Some embodiments herein provide compositions and methods for expressing secreted and cell-surface-bound polypeptides in a single cell. In some embodiments, secreted and cell-surface polypeptide are...
8594600 Apparatus for the self healing of the gain of broadband receivers  
An integrated RF device includes at least one RF amplifier configured to be electrically coupled alternatively to a selected one of a RF signal input and a RF test source. A first mixer stage...
8593638 Split frequency sensing methods and systems  
Resonant sensors and molecule detection methods utilizing split frequency. Optical energy is introduced into a microcavity, such as a toroid-shaped or spherical microcavity. A portion of the...
8592215 Microfabricated crossflow devices and methods  
This invention provides microfabricated devices and methods for detecting, analyzing and sorting biological materials and particles. Droplets containing the particles are provided in an extrusion...
8591758 Mechanochemical synthesis and thermoelectric properties of magnesium silicide and related alloys  
The present invention provides a method of making a substantially phase pure compound including a cation and an anion. The compound is made by mixing in a ball-milling device a first amount of the...