Patents and Patent Applications from Brown University


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9687672 Optogenetic control of endothelial cells  
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to...
US20170176606 METHOD AND APPARATUS FOR CREATING COHERENT BUNDLE OF SCINTILLATING FIBERS  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. In the method and apparatus, a polymer matrix of a transparent polymer and nanoparticle scintillators...
US20170176383 DEVICES AND METHODS FOR CONTAINING MOLECULES  
The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically...
US20170167738 APPARATUS AND METHOD FOR PASSIVELY COOLING AN INTERIOR  
A system passively cools, regulates humidity and/or rectifies diffusive transport of water vapor in an interior area within a structure. The system includes a membrane assembly covering a portion...
9679409 System and method for simulating realistic clothing  
Systems, methods, and computer-readable storage media for simulating realistic clothing. The system generates a clothing deformation model for a clothing type, wherein the clothing deformation...
9675783 Intracranial fixation device  
A fixation device including a base structure such as a faceplate having an inferior surface capable of contacting a surface of a skull of a patient, having a superior surface, and defining at...
9662880 Integrated thin film piezoelectric printhead  
A method and structure for a piezoelectric ink jet printhead. The method can include forming a piezoelectric composite from a liquid sol-gel solution. A first layer of the liquid sol-gel solution...
US20170121773 METHODS FOR THE DIAGNOSIS AND TREATMENT OF PULMONARY FIBROSIS IN SUBJECTS WITH HERMANSKY PUDLAK SYNDROME  
Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of Hermansky Pudlak Syndrome (HPS) and, e.g., pulmonary fibrosis in a subject. As described...
US20170107253 NEUROPROTECTIVE COMPOSITION AND METHOD OF USE  
A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines, and further comprising 1 or more terminal cysteines. The composition is administered...
9611168 Method and apparatus for creating coherent bundle of scintillating fibers  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. In the method and apparatus, a polymer matrix of a transparent polymer and nanoparticle scintillators...
US20170082873 HIGH FREQUENCY LIGHT EMISSION DEVICE  
Systems, apparatuses, and methods for modulating light at high frequencies by addressing the issue of direct modulation of long lifetime light emitters. Dynamic control of the local density of...
US20170078649 METHOD AND SYSTEM FOR UNSYNCHRONIZED STRUCTURED LIGHTING  
A system and method to capture the surface geometry a three-dimensional object in a scene using unsynchronized structured lighting is disclosed. The method and system includes a pattern projector...
US20170072691 INTEGRATED THIN FILM PIEZOELECTRIC PRINTHEAD  
A method and structure for a piezoelectric ink jet printhead. The method can include forming a piezoelectric composite from a liquid sol-gel solution. A first layer of the liquid sol-gel solution...
US20170069815 GRADED THERMOELECTRIC MATERIALS  
This disclosure provides systems, methods, and apparatus related to graded thermoelectric materials. In one aspect, a method includes providing a plurality of nanostructures. The plurality of...
US20170069102 PARAMETERIZED MODEL OF 2D ARTICULATED HUMAN SHAPE  
Disclosed are computer-readable devices, systems and methods for generating a model of a clothed body. The method includes generating a model of an unclothed human body, the model capturing a...
US20170067121 Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies  
Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for...
9587213 Methods and devices for encapsulating cells  
Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing...
9586192 Functionalized media and methods of making and using therefor  
Methods, compositions, devices and kits are provided herein for separating, scavenging, capturing or identifying a metal from a target using a medium or scaffold with a selenium-containing...
9576198 Methods and apparatus for identifying subject matter in view data  
In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of...
US20170047054 SYSTEM FOR ELECTRONICALLY GENERATING MUSIC  
A musical instrument for electronically producing music from audio segments. The musical instrument comprises: an apparatus having a first surface; a plurality of selectable elements disposed in a...
US20170042713 SYSTEM AND METHODS FOR MOBILE MEDICAL MONITORING  
A portable monitoring device for whole-body monitoring can include a receiver configured to receive wireless signals representing real-time neural activity from a neural sensor and to process the...
9564650 Methods for continuous direct carbon fuel cell operation with a circulating electrolyte slurry  
The present invention relates to methods and systems related to fuel cells, and in particular, to direct carbon fuel cells. The methods and systems relate to cleaning and removal of components...
US20160364507 RARE-EVENT SAMPLING  
Systems and methods are disclosed for a new approach to the rare-event Monte Carlo sampling problem. This technique utilizes a symmetrization strategy to create probability distributions that are...
9489744 Parameterized model of 2D articulated human shape  
A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 2D part-based model. The CP model...
US20160303775 METHOD FOR HIGHLY CONDUCTIVE GRAPHENE-BASED SEGREGATED COMPOSITES  
A method is disclosed of dispersing conductive particles within a polymer. The method includes the steps of providing dry polymer particles, adding conductive material to the dry polymer particles...
US20160303186 CYCLIC-GLUR6 ANALOGS, METHODS OF TREATMENT AND USE  
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising whereinR is a molecular transporter with or without a linker amino acid;R1 is at least about one...
9468680 Differential effects of drugs on transport in a multi-layer 3D spheroid model  
Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the...
US20160279619 Graphene-Supported NiPd Alloy Nanoparticles for Effective Catalysis of Tandem Dehydrogenation of Ammonia Borane and Hydrogenation of Nitro/Nitrile Compounds  
Monodisperse NiPd alloy nanoparticles (NPs) are synthesized and assembled on graphene (G) or other support to provide clean, efficient catalysis of tandem reactions—dehydrogenation of ammonia...
9453061 Method and compositions for treatment of calcineurin-related diseases  
Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein...
US20160275693 PARAMETERIZED MODEL OF 2D ARTICULATED HUMAN SHAPE  
A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 2D part-based model. The CP model...
US20160274086 Methods compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging  
Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues....
US20160272938 Topographical Templating Of Polymeric Materials Using Cellular Morphology  
Substrates for influencing the organization, spreading or adhesion of a selected cell to induce or stimulate growth, differentiation on regeneration of the cell or of tissue constituting the cells...
US20160263183 METHODS FOR TREATING LUNG DISEASE  
The methods and assays described herein relate to the diagnosis, prognosis, and treatment of subjects with emphysema, COPD, and/or cigarette-induced lung damage. In some embodiments, the methods...
US20160230295 Method for Electrocatalytic Reduction using Au Nanoparticles Tuned or Optimized for Reduction of CO2 to CO  
Selective electrocatalytic reduction of carbon dioxide (CO2) to carbon monoxide (CO) on gold (Au) nanoparticles (NPs) in 0.5 M KHCO3 at 25° C. Among monodisperse 4-, 6-, 8-, and 10-nm NPs tested,...
US20160221977 ANTIBACTERIAL BETA-LACTONES, AND METHODS OF IDENTIFICATION, MANUFACTURE AND USE  
An antibacterial therapeutic wherein R1 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy,...
9403876 Cyclic-GluR6 analogs, methods of treatment and use  
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising whereinR is a molecular transporter with or without a linker amino acid;R1 is at least about one...
US20160216234 DEVICES AND METHODS FOR CONTAINING MOLECULES  
The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically...
US20160215404 ELECTROCHEMICAL REDUCTION OF CO2 AT COPPER NANOFOAMS  
This invention includes a catalytic copper electrode is selected from the group comprising copper nanofoam, copper aerogel, and copper nanoparticles. Particular note is made of the catalytic...
US20160203361 METHOD AND APPARATUS FOR ESTIMATING BODY SHAPE  
A system and method of estimating the body shape of an individual from input data such as images or range maps. The body may appear in one or more poses captured at different times and a...
US20160193296 METHODS FOR TREATMENT OF MICROCEPHALY ASSOCIATED AUTISM DISORDERS  
The invention features methods for the treatment of one or more symptoms of microcephaly associated autism disorders e.g., Christianson syndrome, by administering agents that increase the level or...
US20160182006 High-Selectivity Low-Loss Duplexer  
A high-selectivity low-loss duplexing system includes a first duplexer having a first port, a second port, a transmit port and a receive port. A second duplexer has a third port, a fourth port, an...
9373931 Red, green, and blue lasing enabled by single-exciton gain in colloidal quantum dot films  
The methods and materials described herein contemplate the use films of colloidal quantum dots as a gain medium in a vertical-cavity surface-emitting laser. The present disclosure demonstrates a...
9371347 dppf-like compounds and method of manufacture and use  
A method of β-hydride elimination and subsequent 2,1-insertion from a transient nickel(II) acrylate hydride intermediate (Structure I). Also addressed is treatment of (dppe)Ni(CH(CH3)CO2BArf3)...
US20160169865 High-Speed Molecular Diagnostics  
A system for high-speed molecular diagnostics includes a self-resetting continuous-time integrator configured to integrate an input current on one of a plurality of integration capacitors to...
US20160166520 METHODS AND COMPOSITIONS RELATING TO THE TREATMENT OF VISCERAL FAT AND ASTHMA  
The technology described herein is directed to methods of treating, e.g., obesity and/or asthma which relate to the interacting roles of Chi3L1 and Sirt1 in controlling adipose tissue and...
9355813 Microfluidic blotless cryo TEM device and method  
A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a...
US20160139149 CHI3L1 FOR THE DETECTION AND TREATMENT OF NONALCOHOLIC STEATOHEPATITIS  
Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from...
US20160136232 TUNABLE ANTI-MICROBIAL LOADED HYDROGELS  
A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion...
US20160130257 Macrocyclic proteasome inhibitors  
Compositions are provided for selectively inhibiting bacterial proteasome. Also provided are methods for assaying the compositions, methods for treating bacterial infection, and methods for...
US20160124443 POWER MAPPING AND MODELING SYSTEM FOR INTEGRATED CIRCUITS  
This invention relates in general to a system, apparatus, and method comprises one or more mapping and modeling systems used for power estimation, management, and improved efficiencies for the...