Patents and Patent Applications from Brown University


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US20180245155 Compositions and Methods for Identifying Genetic Predisposition to Obesity and for Enhancing Adipogenesis  
The present invention provides compositions and methods for identifying a subject as having a genetic predisposition to obesity or at risk of developing obesity. The present invention also...
10058506 Tunable anti-microbial loaded hydrogels  
A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion...
10046024 Cyclic-GluR6 analogs, methods of treatment and use  
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising whereinR is a molecular transporter with or without a linker amino acid;R1 is at least about one...
US20180225516 METHOD AND SYSTEM FOR AUTOMATED BEHAVIOR CLASSIFICATION OF TEST SUBJECTS  
The method and system includes a plurality of test subject containers, each having a test subject therein. A plurality of video cameras is focused on the test subject containers to capture video...
US20180224137 APPARATUS AND METHOD FOR PASSIVELY COOLING AN INTERIOR  
A system passively cools an interior area within a structure. The system includes a membrane assembly covering a portion of the structure, wherein the membrane has an interior side facing the...
10040822 Neuroprotective composition and method of use  
A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines (SEQ ID NO: 1), and further comprising 1 or more terminal cysteines. The composition...
US20180212750 HOMOMORPHIC ENCRYPTION  
Systems, methods, and computer-readable storage devices storing instructions for homomorphic encryption via finite ring isomorphisms are provided. An example method includes selecting a polynomial...
US20180206320 MODULAR LASER-PRODUCED PLASMA X-RAY SYSTEM  
A laser-produced plasma X-ray system includes a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the...
US20180206319 MODULAR LASER-PRODUCED PLASMA X-RAY SYSTEM  
A laser-produced plasma X-ray system including a liquid metal flow system enclosed within a low-pressure chamber, the flow system including a liquid metal, wherein in at least one location on the...
10008007 Method for generating an array of 3-D points  
A method that estimates the coordinates of the calibration points in the projector image plane using local homographies obtained from the imaging camera. First, a dense set of correspondences...
10002597 System for electronically generating music  
A musical instrument for electronically producing music from audio segments. The musical instrument comprises: an apparatus having a first surface; a plurality of selectable elements disposed in a...
10002460 Method and apparatus for estimating body shape  
A system and method of estimating the body shape of an individual from input data such as images or range maps. The body may appear in one or more poses captured at different times and a...
9994905 Methods for the diagnosis and treatment of pulmonary fibrosis in subjects with hermansky pudlak syndrome  
Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of Hermansky Pudlak Syndrome (HPS) and, e.g., pulmonary fibrosis in a subject. As described...
US20180153617 Heat Substrate and/or Image Enhancement Compositions and Enhanced Tissue Ablation Methods  
Ferritin or iron-based image enhancement agents identify target tissue for treatment or ablation and are heated by microwave absorption. Microwave heat substrates enhance microwave hyperthermal...
US20180151813 ORGANO-METAL HALIDE PEROVSKITES FILMS AND METHODS OF MAKING THE SAME  
An aspect of the present disclosure is a method that includes applying a solution that includes a first solvent, a halogen-containing precursor, and a metal halide to a substrate to form a coating...
US20180136461 VIRTUAL REALITY METHODS AND SYSTEMS  
Some aspects include a virtual reality device configured to present to a user a virtual environment. The virtual reality device comprises a tracking device including at least one camera to acquire...
9969785 Biglycan mutants and related therapeutics and methods of use  
The present disclosure provides compositions and methods for treating diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable...
US20180131044 IN-SITU X-RAY SCATTER IMAGING OF BATTERY ELECTRODES  
A method and apparatus for in-situ x-ray scatter imaging of battery electrodes. An apparatus includes an X-ray source, a grid, the grid comprising stainless steel wires with uniform spacing, and a...
US20180122146 PARAMETERIZED MODEL OF 2D ARTICULATED HUMAN SHAPE  
Disclosed are computer-readable devices, systems and methods for generating a model of a clothed body. The method includes generating a model of an unclothed human body, the model capturing a...
9958458 Therapeutic and diagnostic methods involving biglycan and utrophin  
The present disclosure provides methods for predicting a patient's response to biglycan therapy for diseases or conditions associated with an abnormal level or activity of biglycan; disorders...
US20180108905 CATION ENERGY STORAGE DEVICE AND METHODS  
An energy storage composition can be used as a new Na-ion battery cathode material. The energy storage composition with an alluaudite phase of AxTy(PO4)z, NaxTy(PO4)z, Na1.702Fe3(PO4)3 and...
US20180066953 NAVIGATION METHODS AND APPARATUS FOR THE VISUALLY IMPAIRED  
According to some aspects, a wearable device for estimating a location of the device within a space is provided, the device comprising a plurality of cameras mounted to a structure, at least a...
US20180066249 METHODS FOR LABELING AND MANIPULATING A CELLULAR CIRCUIT  
The invention relates to methods and kits for labeling and manipulating a cellular circuit. The methods includes transfecting a first-order cell in the cellular circuit with a nucleic acid...
US20180044397 MINIMALLY-INVASIVE AND ACTIVITY-DEPENDENT CONTROL OF EXCITABLE CELLS  
The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be...
US20180015296 OPTOGENETIC CONTROL OF ENDOTHELIAL CELLS  
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to...
US20180000379 Patient Reminder System and Method for Incentive Spirometer Utilization  
A system and method for configuring and/or utilizing an incentive spirometer to interact with a user during a series of sessions, the incentive spirometer having a piston that is movable within a...
9853623 High-selectivity low-loss duplexer  
A high-selectivity low-loss duplexing system includes a first duplexer having a first port, a second port, a transmit port and a receive port. A second duplexer has a third port, a fourth port, an...
9851795 Context-aware self-calibration  
A method for context-aware self-calibration includes measuring for a plurality of time segments, at least one feature of at least one biosignal or each of at least one channel. Each biosignal is...
US20170365416 Method of Making Coated Substrates  
Methods' and compositions for making coated substrates using a co-solvent method are disclosed. Embodiments of the present disclosure relate in general to methods and compositions for making thin...
US20170362114 METHOD AND APPARATUS FOR CREATING COHERENT BUNDLE OF SCINTILLATING FIBERS  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. A method includes providing a collimated bundle having a glass preform with capillaries therethrough...
9834490 Solar-enriched biofuels via looped oxide catalysis  
The invention is an integrated thermochemical process, also known as a looped-oxide catalysis, for providing an upgraded biofuel composition from a biomass-derived feedstock. First, the feedstock...
US20170338021 Beta tungsten thin films with giant spin Hall effect for use in compositions and structures with perpendicular magnetic anisotropy  
Methods, devices, and compositions for use with spintronic devices such as magnetic random access memory (MRAM) and spin-logic devices are provided. Methods include manipulating magnetization...
US20170323476 SYSTEM AND METHOD FOR SIMULATING REALISTIC CLOTHING  
A system generates a clothing deformation model which models one or more of a pose-dependent clothing shape variation which is induced by underlying body pose parameters, a pose-independent...
9810663 Devices and methods for containing molecules  
The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically...
US20170304584 SYSTEMS AND METHODS FOR PREVENTING, MITIGATING, AND/OR TREATING DEMENTIA  
The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-β (Aβ) peptide, C-terminal fragment-β...
US20170300614 HEAT DIFFUSION BASED GENETIC NETWORK ANALYSIS  
Methods and devices are provided for performing heat diffusion based genetic analysis. A network comprising a plurality of genes is defined an initial heat score is assigned to each of the...
US20170273909 COMPOSITIONS FOR STABILIZING AND DELIVERING PROTEINS  
Compositions for stabilizing and delivering proteins and/or other bioactive agents are disclosed. The bioactive agents are embedded or encapsulated in a crystalline matrix. Typically the bioactive...
9771554 Device and method for engineering living tissues  
A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement...
US20170261745 VIRTUAL REALITY METHODS AND SYSTEMS  
Some aspects include a virtual reality device configured to present to a user a virtual environment. The virtual reality device comprises a tracking device including at least one camera to acquire...
9761060 Parameterized model of 2D articulated human shape  
Disclosed are computer-readable devices, systems and methods for generating a model of a clothed body. The method includes generating a model of an unclothed human body, the model capturing a...
US20170244057 METHODS FOR PRODUCING PEROVSKITE HALIDE FILMS  
An aspect of the present disclosure is a method that includes exchanging at least a portion of a first cation of a perovskite solid with a second cation, where the exchanging is performed by...
9738070 Integrated piezo printhead  
An apparatus for a piezoelectric ink-jet printhead is disclosed. Piezoelectric printheads, while more expensive are favored because they use a wider variety of inks. The piezoelectric printhead...
US20170232074 ENHANCEMENT OF SKELETAL MUSCLE STEM CELL ENGRAFTMENT BY DUAL DELIVERY OF VEGF AND IGF-1  
An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors...
9718713 Arsenic removal system  
A system is provided for removing arsenic from water to safe levels at or below the EPA standards. The system is a hybrid spouted vessel/fixed bed filter system that significantly...
US20170199027 OPTICAL SYSTEM AND METHODS FOR THE DETERMINATION OF STRESS IN A SUBSTRATE  
Methods and systems are disclosed for measuring multidimensional stress characteristics in a substrate. Generally, the methods include applying a sequence of optical pump pulses to the substrate....
9695156 Compounds for the treatment and prevention of infections  
Provided herein are compounds of Formula (I) or (II): (I) (II) pharmaceutically acceptable salts, tautomers, prodrugs, and stereoisomers thereof, and pharmaceutical compositions thereof, wherein...
US20170182165 THERMAL ACCELERANT COMPOSITIONS AND METHODS OF USE  
A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may...
9687672 Optogenetic control of endothelial cells  
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to...
US20170176606 METHOD AND APPARATUS FOR CREATING COHERENT BUNDLE OF SCINTILLATING FIBERS  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. In the method and apparatus, a polymer matrix of a transparent polymer and nanoparticle scintillators...
US20170176383 DEVICES AND METHODS FOR CONTAINING MOLECULES  
The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically...