Patents and Patent Applications from Brown University


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US20180044397 MINIMALLY-INVASIVE AND ACTIVITY-DEPENDENT CONTROL OF EXCITABLE CELLS  
The present invention provides a method of bioluminescence-driven optogenetic control of excitable cells. The excitable cell expresses a light-gated ion channel, and a luminescent protein can be...
US20180015296 OPTOGENETIC CONTROL OF ENDOTHELIAL CELLS  
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to...
US20180000379 Patient Reminder System and Method for Incentive Spirometer Utilization  
A system and method for configuring and/or utilizing an incentive spirometer to interact with a user during a series of sessions, the incentive spirometer having a piston that is movable within a...
9853623 High-selectivity low-loss duplexer  
A high-selectivity low-loss duplexing system includes a first duplexer having a first port, a second port, a transmit port and a receive port. A second duplexer has a third port, a fourth port, an...
9851795 Context-aware self-calibration  
A method for context-aware self-calibration includes measuring for a plurality of time segments, at least one feature of at least one biosignal or each of at least one channel. Each biosignal is...
US20170365416 Method of Making Coated Substrates  
Methods' and compositions for making coated substrates using a co-solvent method are disclosed. Embodiments of the present disclosure relate in general to methods and compositions for making thin...
US20170362114 METHOD AND APPARATUS FOR CREATING COHERENT BUNDLE OF SCINTILLATING FIBERS  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. A method includes providing a collimated bundle having a glass preform with capillaries therethrough...
9834490 Solar-enriched biofuels via looped oxide catalysis  
The invention is an integrated thermochemical process, also known as a looped-oxide catalysis, for providing an upgraded biofuel composition from a biomass-derived feedstock. First, the feedstock...
US20170338021 Beta tungsten thin films with giant spin Hall effect for use in compositions and structures with perpendicular magnetic anisotropy  
Methods, devices, and compositions for use with spintronic devices such as magnetic random access memory (MRAM) and spin-logic devices are provided. Methods include manipulating magnetization...
US20170323476 SYSTEM AND METHOD FOR SIMULATING REALISTIC CLOTHING  
A system generates a clothing deformation model which models one or more of a pose-dependent clothing shape variation which is induced by underlying body pose parameters, a pose-independent...
9810663 Devices and methods for containing molecules  
The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically...
US20170300614 HEAT DIFFUSION BASED GENETIC NETWORK ANALYSIS  
Methods and devices are provided for performing heat diffusion based genetic analysis. A network comprising a plurality of genes is defined an initial heat score is assigned to each of the...
US20170273909 COMPOSITIONS FOR STABILIZING AND DELIVERING PROTEINS  
Compositions for stabilizing and delivering proteins and/or other bioactive agents are disclosed. The bioactive agents are embedded or encapsulated in a crystalline matrix. Typically the bioactive...
9771554 Device and method for engineering living tissues  
A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement...
US20170261745 VIRTUAL REALITY METHODS AND SYSTEMS  
Some aspects include a virtual reality device configured to present to a user a virtual environment. The virtual reality device comprises a tracking device including at least one camera to acquire...
9761060 Parameterized model of 2D articulated human shape  
Disclosed are computer-readable devices, systems and methods for generating a model of a clothed body. The method includes generating a model of an unclothed human body, the model capturing a...
US20170244057 METHODS FOR PRODUCING PEROVSKITE HALIDE FILMS  
An aspect of the present disclosure is a method that includes exchanging at least a portion of a first cation of a perovskite solid with a second cation, where the exchanging is performed by...
9738070 Integrated piezo printhead  
An apparatus for a piezoelectric ink-jet printhead is disclosed. Piezoelectric printheads, while more expensive are favored because they use a wider variety of inks. The piezoelectric printhead...
US20170232074 ENHANCEMENT OF SKELETAL MUSCLE STEM CELL ENGRAFTMENT BY DUAL DELIVERY OF VEGF AND IGF-1  
An improved device and method for extended repair and regeneration of muscle tissue. An exemplary device comprises (a) a scaffold comprising an ECM component; (b) a combination of growth factors...
9718713 Arsenic removal system  
A system is provided for removing arsenic from water to safe levels at or below the EPA standards. The system is a hybrid spouted vessel/fixed bed filter system that significantly...
US20170199027 OPTICAL SYSTEM AND METHODS FOR THE DETERMINATION OF STRESS IN A SUBSTRATE  
Methods and systems are disclosed for measuring multidimensional stress characteristics in a substrate. Generally, the methods include applying a sequence of optical pump pulses to the substrate....
9695156 Compounds for the treatment and prevention of infections  
Provided herein are compounds of Formula (I) or (II): (I) (II) pharmaceutically acceptable salts, tautomers, prodrugs, and stereoisomers thereof, and pharmaceutical compositions thereof, wherein...
US20170182165 THERMAL ACCELERANT COMPOSITIONS AND METHODS OF USE  
A thermal accelerant is delivered to a tissue site and localized to modulate the shape, extent or other characteristic of RF or microwave-induced hyperthermic tissue ablation. The accelerant may...
9687672 Optogenetic control of endothelial cells  
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to...
US20170176606 METHOD AND APPARATUS FOR CREATING COHERENT BUNDLE OF SCINTILLATING FIBERS  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. In the method and apparatus, a polymer matrix of a transparent polymer and nanoparticle scintillators...
US20170176383 DEVICES AND METHODS FOR CONTAINING MOLECULES  
The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically...
US20170167738 APPARATUS AND METHOD FOR PASSIVELY COOLING AN INTERIOR  
A system passively cools, regulates humidity and/or rectifies diffusive transport of water vapor in an interior area within a structure. The system includes a membrane assembly covering a portion...
9679409 System and method for simulating realistic clothing  
Systems, methods, and computer-readable storage media for simulating realistic clothing. The system generates a clothing deformation model for a clothing type, wherein the clothing deformation...
9675783 Intracranial fixation device  
A fixation device including a base structure such as a faceplate having an inferior surface capable of contacting a surface of a skull of a patient, having a superior surface, and defining at...
9662880 Integrated thin film piezoelectric printhead  
A method and structure for a piezoelectric ink jet printhead. The method can include forming a piezoelectric composite from a liquid sol-gel solution. A first layer of the liquid sol-gel solution...
US20170121773 METHODS FOR THE DIAGNOSIS AND TREATMENT OF PULMONARY FIBROSIS IN SUBJECTS WITH HERMANSKY PUDLAK SYNDROME  
Described herein are methods, assays, and systems related to the prognosis, diagnosis, and treatment of Hermansky Pudlak Syndrome (HPS) and, e.g., pulmonary fibrosis in a subject. As described...
US20170107253 NEUROPROTECTIVE COMPOSITION AND METHOD OF USE  
A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines, and further comprising 1 or more terminal cysteines. The composition is administered...
9611168 Method and apparatus for creating coherent bundle of scintillating fibers  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. In the method and apparatus, a polymer matrix of a transparent polymer and nanoparticle scintillators...
US20170082873 HIGH FREQUENCY LIGHT EMISSION DEVICE  
Systems, apparatuses, and methods for modulating light at high frequencies by addressing the issue of direct modulation of long lifetime light emitters. Dynamic control of the local density of...
US20170078649 METHOD AND SYSTEM FOR UNSYNCHRONIZED STRUCTURED LIGHTING  
A system and method to capture the surface geometry a three-dimensional object in a scene using unsynchronized structured lighting is disclosed. The method and system includes a pattern projector...
US20170072691 INTEGRATED THIN FILM PIEZOELECTRIC PRINTHEAD  
A method and structure for a piezoelectric ink jet printhead. The method can include forming a piezoelectric composite from a liquid sol-gel solution. A first layer of the liquid sol-gel solution...
US20170069815 GRADED THERMOELECTRIC MATERIALS  
This disclosure provides systems, methods, and apparatus related to graded thermoelectric materials. In one aspect, a method includes providing a plurality of nanostructures. The plurality of...
US20170069102 PARAMETERIZED MODEL OF 2D ARTICULATED HUMAN SHAPE  
Disclosed are computer-readable devices, systems and methods for generating a model of a clothed body. The method includes generating a model of an unclothed human body, the model capturing a...
US20170067121 Methods using DNA methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies  
Methods using DNA Methylation arrays are provided for identifying a cell or mixture of cells and for quantification of alterations in distribution of cells in blood or in tissues, and for...
9587213 Methods and devices for encapsulating cells  
Molds for making cell aggregation devices include upper and lower surfaces. Methods of aggregating cells include depositing cells on in a seeding chamber, incubating the cells and removing...
9586192 Functionalized media and methods of making and using therefor  
Methods, compositions, devices and kits are provided herein for separating, scavenging, capturing or identifying a metal from a target using a medium or scaffold with a selenium-containing...
9576198 Methods and apparatus for identifying subject matter in view data  
In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of...
US20170047054 SYSTEM FOR ELECTRONICALLY GENERATING MUSIC  
A musical instrument for electronically producing music from audio segments. The musical instrument comprises: an apparatus having a first surface; a plurality of selectable elements disposed in a...
US20170042713 SYSTEM AND METHODS FOR MOBILE MEDICAL MONITORING  
A portable monitoring device for whole-body monitoring can include a receiver configured to receive wireless signals representing real-time neural activity from a neural sensor and to process the...
9564650 Methods for continuous direct carbon fuel cell operation with a circulating electrolyte slurry  
The present invention relates to methods and systems related to fuel cells, and in particular, to direct carbon fuel cells. The methods and systems relate to cleaning and removal of components...
US20160364507 RARE-EVENT SAMPLING  
Systems and methods are disclosed for a new approach to the rare-event Monte Carlo sampling problem. This technique utilizes a symmetrization strategy to create probability distributions that are...
9489744 Parameterized model of 2D articulated human shape  
A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 2D part-based model. The CP model...
US20160303775 METHOD FOR HIGHLY CONDUCTIVE GRAPHENE-BASED SEGREGATED COMPOSITES  
A method is disclosed of dispersing conductive particles within a polymer. The method includes the steps of providing dry polymer particles, adding conductive material to the dry polymer particles...
US20160303186 CYCLIC-GLUR6 ANALOGS, METHODS OF TREATMENT AND USE  
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising whereinR is a molecular transporter with or without a linker amino acid;R1 is at least about one...
9468680 Differential effects of drugs on transport in a multi-layer 3D spheroid model  
Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the...