Patents and Patent Applications from Brown University


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9355813 Microfluidic blotless cryo TEM device and method  
A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a...
US20160139149 CHI3L1 FOR THE DETECTION AND TREATMENT OF NONALCOHOLIC STEATOHEPATITIS  
Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from...
US20160136232 TUNABLE ANTI-MICROBIAL LOADED HYDROGELS  
A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion...
US20160130257 Macrocyclic proteasome inhibitors  
Compositions are provided for selectively inhibiting bacterial proteasome. Also provided are methods for assaying the compositions, methods for treating bacterial infection, and methods for...
US20160124443 POWER MAPPING AND MODELING SYSTEM FOR INTEGRATED CIRCUITS  
This invention relates in general to a system, apparatus, and method comprises one or more mapping and modeling systems used for power estimation, management, and improved efficiencies for the...
9330295 Spatial sequencing/gene expression camera  
Methods, articles and systems that provide imagewise mapping or display of gene expression of a biosample, by contacting the biosample, such as a tissue slice or metacommunity, to a detector which...
9329224 Optical testing of a multi quantum well semiconductor device  
A pump light pulse is generating a strain pulse in a sample that includes quantum wells. A signal is measured using a probe light pulse. The probe light pulse is delayed in relation to the pump...
9316645 Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging  
Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues....
US20160104026 METHODS AND APPARATUS FOR IDENTIFYING SUBJECT MATTER IN VIEW DATA  
In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of...
9312095 Method and system for automating sample preparation for microfluidic cryo TEM  
A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a...
US20160094830 System and Methods for Shape Measurement Using Dual Frequency Fringe Patterns  
A method obtains the shape of a target by projecting and recording images of dual frequency fringe patterns. Locations in each projector image plane are encoded into the patterns and projected...
9292967 Parameterized model of 2D articulated human shape  
A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 20 part-based model. The CP model...
US20160073887 OPTOELECTRONIC DEVICE TO WRITE-IN AND READ-OUT ACTIVITY IN BRAIN CIRCUITS  
Systems, apparatus and methods for a neural implant are provided. In one embodiment, a neural implant that can both optically stimulate neurons and record electrical signals from neurons is...
9285314 Systems and methods enabling high-throughput, real time detection of analytes  
System and methods for detecting analytes are provided. The system includes a plasmonic interferometer with a first surface having a first and second scattering element and an aperture disposed...
US20160067689 OVERPOTENTIAL AND SELECTIVITY IN THE ELECTROCHEMICAL CONVERSION OF CO2 INTO FUELS  
The invention provides a catalyst and method for producing hydrocarbons from a carbon dioxide source comprising carbides, in particular one or more metal carbides. The one or more metal carbides...
9267853 Device and methods for temperature and humidity measurements using a nanocomposite film sensor  
Devices and methods are provided for a nanocomposite having a phase change polymer matrix and conductive nanoparticles to provide greatly enhanced responsivity to temperature and/or humidity. A...
US20160046684 Methods and compositions for treatment of PTP1B-related diseases  
Cancer, obesity, and diabetes are examples of PTP1B-related diseases. The invention herein provides embodiments of therapeutic methods and compositions for treating PTP1B related diseases by...
US20160046674 ENOPEPTINS, USES THEREOF, AND METHODS OF SNYTHESIS THEREOF  
Provided herein are inventive enopeptin compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Further provided are methods of...
9259005 Antipathogenic surfaces having selenium nanoclusters  
The present invention is directed to methods for inhibiting growth of pathogens and to substrates with selenium nanoparticles or selenium nanoclusters having antipathogenic properties.
US20160038571 Method and compositions for treatment of calcineurin-related diseases  
Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein...
US20160033484 SERUM-BASED, DIAGNOSTIC, BIOLOGICAL ASSAY TO PREDICT PREGNANCY DISORDERS  
The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum...
9252214 Apparatus, method and computer program product providing radial addressing of nanowires  
Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded...
9243278 Mechanotransduction by the synergistic action of heterotypic cell interactions  
The candidates are screened and then employed by administering to patients in need thereof of a drug candidate that affects heterotypic intercellular mechanotransduction. At least two types of...
9238011 Compositions, methods and kits for therapeutic treatment with wet spun microstructures  
Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various...
9234285 Electrochemical processing of clathrate hydrates  
A method of using clathrate hydrates (including ammonia clathrates), in electrochemical transformations. Noted are converting clathrate guest molecules such as CO2, CH4, alkanes, and alkenes; and,...
9234248 Simultaneous quantitative multiple primer detection of Clostridium difficile  
This invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of the C. difficile tcdB, tcdC, or cdtB genes, wherein, wherein said primer consists of...
US20160002274 dppf-LIKE COMPOUNDS AND METHOD FO MANUFACTURE AND USE  
A method of β-hydride elimination and subsequent 2,1-insertion from a transient nickel(II) acrylate hydride intermediate (Structure I). Also addressed is treatment of (dppe)Ni(CH(CH3)CO2BArf3)...
US20160000054 HUMAN-DERIVED MUTANTS OF THE dSOD1 GENE IN DROSOPHILA AND METHODS OF MAKING AND USING  
Genetic models of amyotrophic lateral sclerosis (ALS) are described, which can be used to identify novel treatments of ALS and therapeutic targets. Methods for making and using human-derived...
9220714 Nitrofuran compounds for the treatment of cancer and angiogenesis  
The invention is directed to the synthesis and use of nitrofuran compounds, especially Nifurtimox, as medicaments to treat cancer, especially neuroblastoma, and to inhibit angiogenesis. The...
US20150370325 Context-Aware Self-Calibration  
A method for context-aware self-calibration includes measuring for a plurality of time segments, at least one feature of at least one biosignal or each of at least one channel. Each biosignal is...
US20150359886 SYSTEM AND METHODS FOR NANOSTRUCTURE PROTECTED DELIVERY OF TREATMENT AGENT AND SELECTIVE RELEASE THEREOF  
A method and nanoparticle construct provides shielded delivery of a drug or agent to a tissue or treatment site, and release of the agent may be triggered externally. Carbon nanotubes (CNTs) are...
US20150359766 METHODS OF TREATING AUTISM WITH mGluR5 ANTAGONISTS  
mGluR5 antagonists are used for the treatment of autism. The human treated by the methods of the invention can also have fragile X syndrome, epilepsy and anxiety.
9200378 Methods of making nanowires  
The present invention is directed towards methods for growing diamond nanowires via chemical vapor deposition and apparatuses that incorporate these diamond nanowires.
9193767 Enopeptins, uses thereof, and methods of synthesis thereto  
Provided herein are inventive enopeptin compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Further provided are methods of...
9189886 Method and apparatus for estimating body shape  
A system and method of estimating the body shape of an individual from input data such as images or range maps. The body may appear in one or more poses captured at different times and a...
US20150324646 NAVIGATION METHODS AND APPARATUS FOR THE VISUALLY IMPAIRED  
According to some aspects, a wearable device for estimating a location of the device within a space is provided, the device comprising a plurality of cameras mounted to a structure, at least a...
US20150309703 MUSIC CREATION SYSTEMS AND METHODS  
The exemplary systems and methods allow a user to create music using continuous sound structures and other graphical elements using a graphical user interface. The method comprises: depicting a...
US20150297756 Protein-Based Nanobubble X-Ray Imaging Method and Agent  
Systems, compositions, methods and kits employ protein shells, such as ferritin or viral capsid shells, herein called nanobubbles, to enhance X-ray images of cells or body tissue under certain...
9165703 Methods and systems for prolonged localization of drug delivery  
An effective method for prolonging localization of therapeutics within the rat gastrointestinal tract of at least about 12 hours is provided. The method includes localization of therapeutic agents...
US20150293129 DETECTION AND TREATMENT OF PREGNANCY COMPLICATIONS  
Disclosed herein is a method of of identifying and/or addressing incipient preeclampsia in a patient-subject by the steps of by the steps of (a) performing a bioassay to determine the level of at...
US20150265206 ACCURATE ANALYSIS TOOL AND METHOD FOR THE QUANTITATIVE ACOUSTIC ASSESSMENT OF INFANT CRY  
An automated infant cry analyzer with high accuracy to detect important acoustic features of cry is provided. The system's accuracy was rigorously tested and was compared to ground truth manual...
US20150258213 Nanotubes as Carriers of Nucleic Acids into Cells  
The present invention is directed to transfection complexes of rosette nanotubes and one or more nucleic acids.
US20150253433 METHOD AND APPARATUS FOR CREATING COHERENT BUNDLE OF SCINTALLTING FIBERS  
A method and apparatus to manufacture a coherent bundle of scintillating fibers is disclosed. In the method and apparatus, a polymer matrix of a transparent polymer and nanoparticle scintillators...
9112192 Reactant delivery to a reactive surface in a channel  
The present invention provides geometric arrangements for channels through which liquids or other fluids can be made to flow, for enhanced performance of fuel cells or other chemical or...
US20150224212 FERRITIN-BASED TUMOR TARGETING AGENT, AND IMAGING AND TREATMENT METHODS  
An MRI contrast material includes tumor-targeting metal-loaded ferritin nanoparticles constructed with genetically modified ferritin coupled to a target-specific agent. Ferritin derived from...
US20150216935 Autologous Cell-Based Therapy for Treating Obesity  
Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ASCs)...
9098725 Cryptographic accumulators for authenticated hash tables  
In one exemplary embodiment, an apparatus includes a memory storing data and a processor performing operations. The apparatus generates or maintains an accumulation tree for the stored data—an...
9093715 Multimetallic nanoparticle catalysts with enhanced electrooxidation  
A new structure-control strategy to optimize nanoparticle catalysis is provided. The presence of Au in FePtAu facilitates FePt structure transformation from chemically disordered face centered...
US20150203972 ELECTROCHEMICAL PROCESSING OF CLATHRATE HYDRATES  
A method of using clathrate hydrates (including ammonia clathrates), in electrochemical transformations. Noted are converting clathrate guest molecules such as CO2, CH4, alkanes, and alkenes; and,...
US20150196773 OPTOGENETIC CONTROL OF ENDOTHELIAL CELLS  
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to...