Patents and Patent Applications from Brown University


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9489744 Parameterized model of 2D articulated human shape  
A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 2D part-based model. The CP model...
US20160303775 METHOD FOR HIGHLY CONDUCTIVE GRAPHENE-BASED SEGREGATED COMPOSITES  
A method is disclosed of dispersing conductive particles within a polymer. The method includes the steps of providing dry polymer particles, adding conductive material to the dry polymer particles...
US20160303186 CYCLIC-GLUR6 ANALOGS, METHODS OF TREATMENT AND USE  
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising whereinR is a molecular transporter with or without a linker amino acid;R1 is at least about one...
9468680 Differential effects of drugs on transport in a multi-layer 3D spheroid model  
Drugs are screened for affects on inhibiting efflux pumps and blocking gap junction communication in tumors by culturing cells to thereby form self-assembled spheroids and incubating the...
US20160279619 Graphene-Supported NiPd Alloy Nanoparticles for Effective Catalysis of Tandem Dehydrogenation of Ammonia Borane and Hydrogenation of Nitro/Nitrile Compounds  
Monodisperse NiPd alloy nanoparticles (NPs) are synthesized and assembled on graphene (G) or other support to provide clean, efficient catalysis of tandem reactions—dehydrogenation of ammonia...
9453061 Method and compositions for treatment of calcineurin-related diseases  
Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein...
US20160275693 PARAMETERIZED MODEL OF 2D ARTICULATED HUMAN SHAPE  
A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 2D part-based model. The CP model...
US20160274086 Methods compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging  
Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues....
US20160272938 Topographical Templating Of Polymeric Materials Using Cellular Morphology  
Substrates for influencing the organization, spreading or adhesion of a selected cell to induce or stimulate growth, differentiation on regeneration of the cell or of tissue constituting the cells...
US20160263183 METHODS FOR TREATING LUNG DISEASE  
The methods and assays described herein relate to the diagnosis, prognosis, and treatment of subjects with emphysema, COPD, and/or cigarette-induced lung damage. In some embodiments, the methods...
US20160230295 Method for Electrocatalytic Reduction using Au Nanoparticles Tuned or Optimized for Reduction of CO2 to CO  
Selective electrocatalytic reduction of carbon dioxide (CO2) to carbon monoxide (CO) on gold (Au) nanoparticles (NPs) in 0.5 M KHCO3 at 25° C. Among monodisperse 4-, 6-, 8-, and 10-nm NPs tested,...
US20160221977 ANTIBACTERIAL BETA-LACTONES, AND METHODS OF IDENTIFICATION, MANUFACTURE AND USE  
An antibacterial therapeutic wherein R1 is selected from the group consisting of alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy,...
9403876 Cyclic-GluR6 analogs, methods of treatment and use  
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising whereinR is a molecular transporter with or without a linker amino acid;R1 is at least about one...
US20160216234 DEVICES AND METHODS FOR CONTAINING MOLECULES  
The present invention generally relates to devices and methods for containing molecules. In some embodiments, the device comprises a nanopore, a pore, and a cavity capable of entropically...
US20160215404 ELECTROCHEMICAL REDUCTION OF CO2 AT COPPER NANOFOAMS  
This invention includes a catalytic copper electrode is selected from the group comprising copper nanofoam, copper aerogel, and copper nanoparticles. Particular note is made of the catalytic...
US20160203361 METHOD AND APPARATUS FOR ESTIMATING BODY SHAPE  
A system and method of estimating the body shape of an individual from input data such as images or range maps. The body may appear in one or more poses captured at different times and a...
US20160193296 METHODS FOR TREATMENT OF MICROCEPHALY ASSOCIATED AUTISM DISORDERS  
The invention features methods for the treatment of one or more symptoms of microcephaly associated autism disorders e.g., Christianson syndrome, by administering agents that increase the level or...
US20160182006 High-Selectivity Low-Loss Duplexer  
A high-selectivity low-loss duplexing system includes a first duplexer having a first port, a second port, a transmit port and a receive port. A second duplexer has a third port, a fourth port, an...
9373931 Red, green, and blue lasing enabled by single-exciton gain in colloidal quantum dot films  
The methods and materials described herein contemplate the use films of colloidal quantum dots as a gain medium in a vertical-cavity surface-emitting laser. The present disclosure demonstrates a...
9371347 dppf-like compounds and method of manufacture and use  
A method of β-hydride elimination and subsequent 2,1-insertion from a transient nickel(II) acrylate hydride intermediate (Structure I). Also addressed is treatment of (dppe)Ni(CH(CH3)CO2BArf3)...
US20160169865 High-Speed Molecular Diagnostics  
A system for high-speed molecular diagnostics includes a self-resetting continuous-time integrator configured to integrate an input current on one of a plurality of integration capacitors to...
US20160166520 METHODS AND COMPOSITIONS RELATING TO THE TREATMENT OF VISCERAL FAT AND ASTHMA  
The technology described herein is directed to methods of treating, e.g., obesity and/or asthma which relate to the interacting roles of Chi3L1 and Sirt1 in controlling adipose tissue and...
9355813 Microfluidic blotless cryo TEM device and method  
A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a...
US20160139149 CHI3L1 FOR THE DETECTION AND TREATMENT OF NONALCOHOLIC STEATOHEPATITIS  
Disclosed herein are compositions and methods for detecting nonalcoholic steatohepatitis (NASH) measuring CHI3L1 levels. In some embodiments, the methods described herein can distinguish NASH from...
US20160136232 TUNABLE ANTI-MICROBIAL LOADED HYDROGELS  
A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion...
US20160130257 Macrocyclic proteasome inhibitors  
Compositions are provided for selectively inhibiting bacterial proteasome. Also provided are methods for assaying the compositions, methods for treating bacterial infection, and methods for...
US20160124443 POWER MAPPING AND MODELING SYSTEM FOR INTEGRATED CIRCUITS  
This invention relates in general to a system, apparatus, and method comprises one or more mapping and modeling systems used for power estimation, management, and improved efficiencies for the...
9330295 Spatial sequencing/gene expression camera  
Methods, articles and systems that provide imagewise mapping or display of gene expression of a biosample, by contacting the biosample, such as a tissue slice or metacommunity, to a detector which...
9329224 Optical testing of a multi quantum well semiconductor device  
A pump light pulse is generating a strain pulse in a sample that includes quantum wells. A signal is measured using a probe light pulse. The probe light pulse is delayed in relation to the pump...
9316645 Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging  
Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues....
US20160104026 METHODS AND APPARATUS FOR IDENTIFYING SUBJECT MATTER IN VIEW DATA  
In one aspect, a method and apparatus for detecting subject matter of interest in view data obtained by scanning an object including generating a filter adapted to respond to the subject matter of...
9312095 Method and system for automating sample preparation for microfluidic cryo TEM  
A method and system is provided for automatically preparing transmission electron microscopy (TEM) samples for examination by depositing extremely small samples onto a grid without need for a...
US20160094830 System and Methods for Shape Measurement Using Dual Frequency Fringe Patterns  
A method obtains the shape of a target by projecting and recording images of dual frequency fringe patterns. Locations in each projector image plane are encoded into the patterns and projected...
9292967 Parameterized model of 2D articulated human shape  
A novel “contour person” (CP) model of the human body is proposed that has the expressive power of a detailed 3D model and the computational benefits of a simple 20 part-based model. The CP model...
US20160073887 OPTOELECTRONIC DEVICE TO WRITE-IN AND READ-OUT ACTIVITY IN BRAIN CIRCUITS  
Systems, apparatus and methods for a neural implant are provided. In one embodiment, a neural implant that can both optically stimulate neurons and record electrical signals from neurons is...
9285314 Systems and methods enabling high-throughput, real time detection of analytes  
System and methods for detecting analytes are provided. The system includes a plasmonic interferometer with a first surface having a first and second scattering element and an aperture disposed...
US20160067689 OVERPOTENTIAL AND SELECTIVITY IN THE ELECTROCHEMICAL CONVERSION OF CO2 INTO FUELS  
The invention provides a catalyst and method for producing hydrocarbons from a carbon dioxide source comprising carbides, in particular one or more metal carbides. The one or more metal carbides...
9267853 Device and methods for temperature and humidity measurements using a nanocomposite film sensor  
Devices and methods are provided for a nanocomposite having a phase change polymer matrix and conductive nanoparticles to provide greatly enhanced responsivity to temperature and/or humidity. A...
US20160046684 Methods and compositions for treatment of PTP1B-related diseases  
Cancer, obesity, and diabetes are examples of PTP1B-related diseases. The invention herein provides embodiments of therapeutic methods and compositions for treating PTP1B related diseases by...
US20160046674 ENOPEPTINS, USES THEREOF, AND METHODS OF SNYTHESIS THEREOF  
Provided herein are inventive enopeptin compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Further provided are methods of...
9259005 Antipathogenic surfaces having selenium nanoclusters  
The present invention is directed to methods for inhibiting growth of pathogens and to substrates with selenium nanoparticles or selenium nanoclusters having antipathogenic properties.
US20160038571 Method and compositions for treatment of calcineurin-related diseases  
Therapeutic compositions for treatment of protein serine/threonine phosphatase-related diseases are obtained by engineering amino acid sequences that disrupt interaction between the protein...
US20160033484 SERUM-BASED, DIAGNOSTIC, BIOLOGICAL ASSAY TO PREDICT PREGNANCY DISORDERS  
The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum...
9252214 Apparatus, method and computer program product providing radial addressing of nanowires  
Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded...
9243278 Mechanotransduction by the synergistic action of heterotypic cell interactions  
The candidates are screened and then employed by administering to patients in need thereof of a drug candidate that affects heterotypic intercellular mechanotransduction. At least two types of...
9238011 Compositions, methods and kits for therapeutic treatment with wet spun microstructures  
Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various...
9234285 Electrochemical processing of clathrate hydrates  
A method of using clathrate hydrates (including ammonia clathrates), in electrochemical transformations. Noted are converting clathrate guest molecules such as CO2, CH4, alkanes, and alkenes; and,...
9234248 Simultaneous quantitative multiple primer detection of Clostridium difficile  
This invention comprises a multiplex-capable oligonucleotide which is capable of hybridizing to at least one of the C. difficile tcdB, tcdC, or cdtB genes, wherein, wherein said primer consists of...
US20160002274 dppf-LIKE COMPOUNDS AND METHOD FO MANUFACTURE AND USE  
A method of β-hydride elimination and subsequent 2,1-insertion from a transient nickel(II) acrylate hydride intermediate (Structure I). Also addressed is treatment of (dppe)Ni(CH(CH3)CO2BArf3)...
US20160000054 HUMAN-DERIVED MUTANTS OF THE dSOD1 GENE IN DROSOPHILA AND METHODS OF MAKING AND USING  
Genetic models of amyotrophic lateral sclerosis (ALS) are described, which can be used to identify novel treatments of ALS and therapeutic targets. Methods for making and using human-derived...