Patents and Patent Applications from Boston University Boston Medical Center


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US20170290309 PARKINSONS DISEASE MODEL AND METHODS  
This application provides a novel mouse model (PLA2g6 KOEx2) in which genetic deletion of the N terminus of PLA2g6 results in a loss of dopaminergic (DA) neurons in substantia nigra (SN), and...
9780254 Ultraviolet light emitting diode structures and methods of manufacturing the same  
Semiconductor structures involving multiple quantum wells provide increased efficiency of UV and visible light emitting diodes (LEDs) and other emitter devices, particularly at high driving...
US20170275695 METHODS AND SYSTEMS FOR MONITORING, DIAGNOSING, AND TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE  
A novel set of 98 genes expressed in the respiratory tract epithelium that serve as biomarkers for measuring chronic obstructive pulmonary disease (COPD) activity are provided. Methods of...
US20170274075 THERAPEUTIC AND RESEARCH APPLICATION OF PDCL3  
Described herein are novel compositions comprising, for example, PDCL3 polypeptides having VEGFR-2 inhibitory activity, inhibitory PDCL3 antibodies and PDCL3-binding fragments thereof, or PDCL3...
US20170255857 BIOLOGICAL ANALOG-TO-DIGITAL AND DIGITAL-TO-ANALOG CONVERTERS  
Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs...
US20170252424 Methods and compositions for vaccinating a subject for a sexually transmitted pathogen  
Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly...
US20170252365 IMMUNOMODULATING COMPOSITIONS AND METHODS OF USE THEREOF  
This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of...
US20170234801 STRUCTURED SUBSTRATES FOR OPTICAL SURFACE PROFILING  
This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of...
US20170226591 DETECTION METHODS FOR DISORDERS OF THE LUNG  
The present invention is directed to prognostic and diagnostic methods to assess lung disease risk caused by airway pollutants by analyzing expression of one or more genes belonging to the airway...
9718873 Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin  
The invention features a novel influenza antibody that specifically binds to influenza hemagglutinin and reduces or inhibits hemagglutinin binding to sialic acid. The invention also provides...
9718858 Tunable control of protein degradation in synthetic and endogenous bacterial systems  
The methods and compositions described herein relate, in part, to the generation of a synthetic degradation system in E. coli that provides tunable control of the protein level of targeted genes...
US20170204477 COMPOSITIONS COMPRISING RIBOREGULATORS AND METHODS OF USE THEREOF  
The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use...
US20170202724 Assistive Flexible Suits, Flexible Suit Systems, and Methods for Making and Control Thereof to Assist Human Mobility  
In at least some aspects, the present concepts include a method for configuring an assistive flexible suit including the acts of outfitting a person with an assistive flexible suit, monitoring an...
US20170200865 ULTRAVIOLET LIGHT EMITTING DIODES  
The invention provides ultraviolet (UV) light-emitting diodes (LEDs). The UV LEDs can comprise abase layer including p-type SiC or p-type AlGaN, an active layer, and an n-AlGaN layer, wherein the...
US20170198346 CHEMICAL FUNCTIONALIZATION OF SOLID-STATE NANOPORES AND NANOPORE ARRAYS AND APPLICATIONS THEREOF  
Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used...
US20170193298 METHODS AND APPARATUS FOR AUTONOMOUS ROBOTIC CONTROL  
Sensory processing of visual, auditory, and other sensor information (e.g., visual imagery, LIDAR, RADAR) is conventionally based on “stovepiped,” or isolated processing, with little interactions...
US20170190778 INHIBITORS OF FIBROPROLIFERATIVE DISORDERS AND CANCER  
The present invention generally relates to the field of treatment of fibroproliferative diseases and disorders and cancer. Embodiments of the present invention generally relate to compositions,...
US20170189107 MODULAR DISC ARRAY FOR MINIMALLY INVASIVE MEDICAL DEVICE  
In certain embodiments, an apparatus includes a stacked array of discs electrically coupled together where each disc includes an electrical component. In certain embodiments, a minimally-invasive...
US20170188882 COILS AND COIL ASSEMBLIES THAT ARE RADIO-TRANSLUCENT  
A system that includes at least one coil that is radio-translucent and includes at least one conductor that includes lithium.
US20170188881 TRANSDUCER WITH MAGNETIC NANOWIRE ARRAY  
A transducer includes a planar coil coupled to a magnetic flux guide. The magnetic flux guide includes an array of nanowires. The transducer could include a plurality of magnetic flux guides and a...
9697460 Biological analog-to-digital and digital-to-analog converters  
Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs...
US20170183654 DNA RECOMBINASE CIRCUITS FOR LOGICAL CONTROL OF GENE EXPRESSION  
The invention provides, inter alia, recombinase-based systems that provide for integrated logic and memory in living cells such as mammalian cells. The nucleic acid cassettes, switches, and...
US20170181495 Method and Apparatus to Assist Foot Motion About the Pronation Axis  
An apparatus that assists foot movement includes a normally twisted plate configured to interact with the foot. The foot has a pronation axis, and the normally twisted plate is biased and...
US20170175111 RIBOREGULATOR COMPOSITIONS AND METHODS OF USE  
The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use...
US20170165486 SYSTEM AND METHOD FOR NEURO-STIMULATION  
A neuro-stimulation system employs a includes a stimulator which may include electrode devices and/or vibration elements. A controller may be employed to drive the stimulating elements with an...
9677138 Methods and systems for monitoring, diagnosing, and treating chronic obstructive pulmonary disease  
A novel set of 98 genes expressed in the respiratory tract epithelium that serve as biomarkers for measuring chronic obstructive pulmonary disease (COPD) activity are provided. Methods of...
US20170152563 THERAPEUTIC AGENT FOR EMPHYSEMA AND COPD  
The invention described herein relates to methods of treating emphysema and COPD with a GHK tripeptide. The invention further relates to methods of determining the state of the lungs using...
9664400 Automated technique of measuring room air change rates in HVAC system  
An HVAC system employs a technique built around a system identification/modeling method that determines critical building loads and airflows experimentally without relying on design plans or...
US20170145511 METHODS AND ASSAYS RELATING TO HUNTINGTONS DISEASE AND PARKINSON'S DISEASE  
Described herein are methods for the diagnosis, prognosis, and treatment of neurological conditions, e.g. Huntington's Disease, relating to the misregulation of miRNAs in such conditions.
US20170135584 SYSTEMS, DEVICES, METHODS, APPARATUS AND COMPUTER-ACCESSIBLE MEDIA FOR PROVIDING OPTICAL IMAGING OF STRUCTURES AND COMPOSITIONS  
Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g.,...
US20170131148 DETECTION OF ELECTROMAGNETIC RADIATION USING NONLINEAR MATERIALS  
An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate....
9644036 Predictive marker for topoisomerase I inhibitors  
The present invention generally relates to phospho-serine 10 topoisomerase I antibodies and other protein binding moieties, and kits and uses thereof.
US20170119805 PROTON-MOTIVE FORCE STIMULATION TO POTENTIATE AMINOGLYCOSIDE ANTIBIOTICS AGAINST PERSISTENT BACTERIA  
Provided herein are compositions and methods to improve treatment of chronic infections, and reduce, delay, or inhibit formation of biofilms, using specific combinations of aminoglycoside...
US20170114412 ROBO2 INHIBITORY COMPOSITIONS COMPRISING SLIT2-BINDING EXTRACELLULAR DOMAIN OF ROBO2  
Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression...
9631042 Copolymers having polyisobutylene and biodegradable polymer segments  
The present invention pertains to copolymers having one or more polyisobutylene segments and one or more biodegradable polymer segments, to methods of making such copolymers, to medical articles...
US20170107227 INHIBITORS OF LATE SV40 FACTOR (LSF) AS CANCER CHEMOTHERAPEUTICS  
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a...
9627580 High efficiency ultraviolet light emitting diode with band structure potential fluctuations  
A method of growing an AlGaN semiconductor material utilizes an excess of Ga above the stoichiometric amount typically used. The excess Ga results in the formation of band structure potential...
9626566 Methods and apparatus for autonomous robotic control  
Sensory processing of visual, auditory, and other sensor information (e.g., visual imagery, LIDAR, RADAR) is conventionally based on “stovepiped,” or isolated processing, with little interactions...
9624554 Modular nucleic acid-based circuits for counters, binary operations, memory, and logic  
We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for...
US20170102557 CUSTOMIZED WAVEFRONT-GUIDED METHODS, SYSTEMS, AND DEVICES TO CORRECT HIGHER-ORDER ABERRATION  
Methods and systems for manufacturing a wavefront-guided scleral lens prosthetic device customized for an eye of a patient include obtaining a first scleral lens prosthetic device with a central...
9621268 Optical orthogonal frequency division multiplexing (O-OFDM) system with pulse-width modulation (PWM) dimming  
An optical orthogonal frequency division multiplexing (O-OFDM) system with pulse-width modulation (PWM) dimming includes a driver responsive to one or more predetermined dimming set points...
9617325 Treatment of IgE-mediated disease  
The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble CD23 (sCD23) that binds and sequesters IgE. Thus, the sCD23 peptides, polypeptides...
9616234 System and method for neuro-stimulation  
A neuro-stimulation system employs a includes a stimulator which may include electrode devices and/or vibration elements. A controller may be employed to drive the stimulating elements with an...
US20170095612 BLOOD GLUCOSE CONTROL SYSTEM  
Techniques are used for adaptation of drug-administration parameters that control insulin delivery in a blood glucose control system. One technique provides long-term adaptation of a nominal basal...
9611501 Method and device for rapid detection of bacterial antibiotic resistance/susceptibility  
Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate...
US20170089997 AQUEOUS CONTRAST AGENTS FOR DYNAMIC MRI AND MRA  
In a first aspect this invention provides methods comprising administering an aqueous contrast agent to the vascular system of a subject, and performing a magnetic resonance scan to detect the MR...
9603243 Silk electronic components  
The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or...
9599891 Fabrication of silk fibroin photonic structures by nanocontact imprinting  
A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution,...
9599611 Structured substrates for optical surface profiling  
This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of...
9599605 Parkinson's disease model and methods  
This application provides a novel mouse model (PLA2g6 KOEx2) in which genetic deletion of the N terminus of PLA2g6 results in a loss of dopaminergic (DA) neurons in substantia nigra (SN), and...