Patents and Patent Applications from Boston University Boston Medical Center


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US20190353749 RAY-SURFACE POSITIONING SYSTEMS AND METHODS  
A positioning system includes a steerable laser configured to emit a laser beam, an optical receiver, one or more processors, and a memory device. The optical receiver is configured to detect the...
US20190350179 PARKINSONS DISEASE MODEL AND METHODS  
This application provides a novel mouse model (PLA2g6 KOEx2) in which genetic deletion of the N terminus of PLA2g6 results in a loss of dopaminergic (DA) neurons in substantia nigra (SN), and...
US20190344009 INFUSION SYSTEM AND COMPONENTS THEREOF  
Certain embodiments provide multi-medicament infusion systems for preventing the cross-channeling of medicaments. The system may include one or more of an infusion pump, medicament reservoirs, a...
US20190339268 DYNAMIC TRACKING OF CAPTURED TARGETS FOR ENHANCED DIGITAL BIOSENSING  
Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands...
10465187 Integrated system for programmable DNA methylation  
Provided herein are engineered systems and methods for establishing DNA adenine methylation at specific genomic locations and using DNA adenine methylation as an artificial chemical “handle” on...
US20190334626 System and Method For Embedding Phase and Amplitude Into A Real-Valued Unipolar Signal  
A system for embedding phase and amplitude into a real valued unipolar signal suitable for intensity modulation (IM) by optical transmitters. The system includes a complex-to-unipolar conversion...
US20190331661 CHEMICAL SENSORS WITH NON-COVALENT, ELECTROSTATIC SURFACE MODIFICATION OF GRAPHENE  
Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene...
10451808 MEMS devices for smart lighting applications  
The invention provides a device comprising a movable micromirror adapted to receive light from one or more light source(s) and manipulate the reflected light. The micromirror can be actuated...
10449221 Differentiation of stem cells into thyroid tissue  
Embodiments herein relate in vitro methods of stem cell differentiation into thyroid hormone producing cells and tissues, and methods of use of these cells.
US20190316068 ENGINEERED PLATFORM TO GENERATE 3D CARDIAC TISSUES  
Described herein are a system, device, methods and compositions related to generating 3-dimensional cardiac tissues. Also described herein are a system, device, and methods of maturing...
US20190314799 HALOGEN-CONTAINING METATHESIS CATALYSTS AND METHODS THEREOF  
The present disclosure provides compounds, compositions, and methods for preparing alkenyl halides and/or haloalkyl-substituted olefins with Z-selectivity. The methods are particularly useful for...
US20190310239 SYSTEMS AND METHODS FOR MEASURING WATER AND LIPID CONTENT IN TISSUE SAMPLES  
An imaging system for measuring water and blood lipid content in a tissue sample includes a light source configured to emit a plurality of sequential wavelengths of light within a predetermined...
US20190302209 APPARATUS FOR IMPROVING MAGNETIC RESONANCE IMAGING  
A passive apparatus including a plurality of resonators increases signal-to-noise ratio of radiofrequency signals emitted by a specimen and captured by an MRI machine. The apparatus increases the...
10428043 Green oxidation catalytic system  
Disclosed herein are reaction compositions comprising an oxidation catalyst, a solvent, and a substrate that is dissolved in the solvent. The oxidation catalyst comprises a metal ion complexed...
US20190292600 NASAL EPITHELIUM GENE EXPRESSION SIGNATURE AND CLASSIFIER FOR THE PREDICTION OF LUNG CANCER  
Disclosed herein are assays and methods for diagnosis and prognosis of lung cancer using expression analysis of one or more genes from a biological sample comprising nasal epithelial cells. The...
US20190290100 OPTICAL IMAGING SYSTEM EMPLOYING VORTEX FIBER FOR MULTIPLE-MODE ILLUMINATION  
A vortex optical fiber for use in an illumination subsystem of an optical imaging system (e.g., a stimulated emission depletion (STED) microscopy system) includes an elongated optically...
US20190282665 COMPOSITIONS COMPRISING RELAXIN AND METHODS OF USE THEREOF  
The present invention provides methods for treating a stiffened joint in a subject that comprise administering relaxin, e.g., a PEGylated relaxin-2, to the subject. The relaxin may be administered...
10400064 Glycerol-based polycarbonates  
The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for drug delivery, biodegradable consumer plastics, or solvents for Li-based batteries or...
10392398 Inhibitors of Late SV40 Factor (LSF) as cancer chemotherapeutics  
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a...
10392134 Propulsion and gas-moving systems using travelling-wave gas dielectrophoresis  
A propulsion system for an orbiting vehicle such as a low-Earth orbit (LEO) satellite includes a set of surfaces over which a gas passes during orbital flight, and a plurality of electrodes on the...
10391068 Prion protein ligands as therapeutic agents for neurodegenerative disorders  
The invention provides compositions and methods for treatment of neurodegenerative diseases or disorders, particularly neurodegenerative diseases and disorders associated with protein aggregation....
10390521 Parkinsons disease model and methods  
This application provides a novel mouse model (PLA2g6 KOEx2) in which genetic deletion of the N terminus of PLA2g6 results in a loss of dopaminergic (DA) neurons in substantia nigra (SN), and...
US20190257825 CHEMICAL SENSORS WITH NON-COVALENT SURFACE MODIFICATION OF GRAPHENE  
Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a...
US20190256567 COMPOSITIONS AND METHODS FOR DIAGNOSING AND/OR TREATING KIDNEY INJURY  
One aspect of the technology relates to methods, assays and kits to identify ischemia and ischemic injury, including kidney injury, and are useful in determining efficacy of cancer treatments. In...
US20190254538 BREATH SAMPLING MASK AND SYSTEM  
Embodiments herein include a breath sampling mask, systems, and related methods. In an embodiment, a breath sensing system is included. The breath sensing system can include a breath sampling...
10386368 Isolation of human lung progenitors derived from pluripotent stem cells  
Provided herein are methods and compositions relating, in part, to the generation and isolation of human lung progenitor cells from pluripotent stem cells.
US20190247418 METHODS RELATING TO LUNG CANCER  
The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by...
10378954 Azimuthally-modulated aperiodic phase arrays for engineered spectral separation  
An electromagnetic radiation sorting device comprises an image sensor having an imaging plane; a substrate layer positioned adjacent to and spaced a distance from the imaging plane of the image...
US20190240840 Methods and Apparatus for Early Sensory Integration and Robust Acquisition of Real World Knowledge  
The systems and methods disclosed herein include a path integration system that calculates optic flow, infers angular velocity from the flow field, and incorporates this velocity estimate into...
US20190224336 ACIDIC NANOPARTICLES FOR RESTORATION OF AUTOPHAGY  
In various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acNPs) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy....
10361343 Ultraviolet light emitting diodes  
The invention provides ultraviolet (UV) light-emitting diodes (LEDs). The UV LEDs can comprise abase layer including p-type SiC or p-type AlGaN, an active layer, and an n-AlGaN layer, wherein the...
10358677 Method for treating kidney disease with a SLIT2-binding extracellular domain of ROBO2  
Provided herein are methods for the treatment of chronic kidney disease and proteinuria and for the diagnosis of chronic kidney disease and monitoring the effects of treatment on the progression...
US20190218614 CLONAL HEMATOPOIESIS AND CYTOKINE TARGETS  
As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in one or more HSC cardiometabolic driver genes leads to...
US20190209810 MEDICAL DEVICES, SYSTEMS AND METHODS WITH TIP DEFLECTION  
The present disclosure relates generally to the field of medical devices and establishing access to body passageways. In particular, the present disclosure relates to devices, systems and methods...
US20190208998 FLUOROPHORE IMAGING DEVICES, SYSTEMS, AND METHODS FOR AN ENDOSCOPIC PROCEDURE  
Fluorescent imaging systems for performing an endoscopic procedure, such as a retrograde cholangiopancreatography (ERCP) procedure may include a first light source for emitting light in the...
US20190208997 FLUOROPHORE IMAGING DEVICES, SYSTEMS, AND METHODS FOR AN ENDOSCOPIC PROCEDURE  
The present disclosure relates generally to fluorescent imaging devices, systems, and methods for an endoscopic procedure, and in particular, indocyanine green (ICG) fluorescence. In some...
US20190208990 DEVICES, SYSTEMS AND METHODS FOR TRANSMITTING MOTION TO THE DISTAL TIP OF AN ENDOSCOPIC ACCESSORY TOOL  
The present disclosure relates generally to the field of medical devices and establishing access to body passageways. In particular, the present disclosure relates to devices, systems and methods...
10337995 Systems and methods for oblique laser scanning  
A method for constructing a three-dimensional image of a sample includes producing electromagnetic radiation and directing the produced electromagnetic radiation such that it is incident on the...
US20190195894 MICROBIAL-BASED BIOSENSORS  
Described herein are methods, compositions and processes related to a microbial-based biosensor system for the detection of small molecules and analytes based on an analyte-responsive...
10324152 Apparatus for improving magnetic resonance imaging  
A passive apparatus including a plurality of resonators increases signal-to-noise ratio of radiofrequency signals emitted by a specimen and captured by an MRI machine. The apparatus increases the...
US20190179127 MULTI-Z CONFOCAL IMAGING SYSTEM  
A Multi-Z confocal microscopy system can simultaneously record from multiple Z-sections, and thus performs high speed volumetric imaging. An illumination line can be formed by under-filling the...
10314855 Methods relating to lung cancer  
The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by...
10314810 Aryl hydrocarbon receptor (AhR) modifiers as novel cancer therapeutics  
Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis....
10314503 Systems and methods for tracking non-stationary spectral structure and dynamics in physiological data  
Systems and methods for tracking dynamic structure in physiological data are provided. In some aspects, the method includes providing physiological data, including electroencephalogram (“EEG”)...
US20190165859 VISIBLE-LIGHT COMMUNICATIONS RECEIVER  
An optical wireless communications receiver includes a set of photodetectors and signal processing circuitry that receive and process optical communications signals to generate receive data. The...
US20190162647 METHOD AND SYSTEM FOR ENHANCED SINGLE PARTICLE REFLECTANCE IMAGING  
An enhanced single particle interferometric reflectance imaging system includes an illumination source configured to produce illumination light along an illumination path toward a target...
10300603 Methods and apparatus for early sensory integration and robust acquisition of real world knowledge  
The systems and methods disclosed herein include a path integration system that calculates optic flow, infers angular velocity from the flow field, and incorporates this velocity estimate into...
US20190153502 METHOD AND DEVICE FOR ANTIBIOTIC SUSCEPTIBILITY TESTING BASED ON FLUCTUATIONS OF ELECTRICAL RESISTANCE IN A MICROCHANNEL  
A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing...
US20190153106 brANTI-DEspR MONOCLONAL ANTIBODY TARGETED THERAPY AND IMAGING FOR CANCER AND STROKE  
Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof derived from 6G8G7 and 7C5B2 anti-DEspR variant antibodies, including fully human, composite...
US20190142860 NUCLEIC ACID BASED TIA-1 INHIBITORS  
The disclosure provides, e.g., nucleic acid based inhibitors of TIA-1. The inhibitors can be, e.g., a double stranded RNA (e.g., a siRNA or shRNA), an antisense RNA, or a microRNA (miRNA). The...