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8183222 |
Method to inhibit cell growth using oligonucleotides
Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more...
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8182804 |
Engineered enzymatically active bacteriophages and methods of uses thereof
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also...
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US20120122831 |
METHOD AND DEVICE FOR RAPID DETECTION OF BACTERIAL ANTIBIOTIC RESISTANCE/SUSCEPTIBILITY
Described herein is a method and a device for expediting delivery of an agent to a damaged bacterial cell. In one embodiment, the methods and devices are useful for screening candidate antibiotics....
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US20120121820 |
FABRICATION OF SILK FIBROIN PHOTONIC STRUCTURES BY NANOCONTACT IMPRINTING
A method of manufacturing a nanopatterned biophotonic structure includes forming a customized nanopattern mask on a substrate using E-beam lithography, providing a biopolymer matrix solution,...
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US20120115705 |
DISPOSABLE SEPARATOR/CONCENTRATOR DEVICE AND METHOD OF USE
The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is...
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US20120114566 |
LIPOXIN ANALOGS AND METHODS FOR THE TREATMENT OF PERIODONTAL DISEASE
This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including...
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US20120107365 |
FILMS AND PARTICLES
Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
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US20120088241 |
Bioreactive Agents
This invention relates to agents and conjugates to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent...
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8153377 |
Method for detecting and quantifying rare mutations/polymorphisms
The present invention is directed to a method for detecting and quantifying rare mutations in a nucleic acid sample. The nucleic acid molecules under investigation can be either DNA or RNA. The...
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8153119 |
Engineered enzymatically active bacteriophage and methods for dispersing biofilms
The present invention is directed to engineered enzymatically active bacteriophages that are both capable of killing the bacteria by lysis and dispersing the bacterial biofilm because they have...
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US20120077260 |
RESERVOIR-BUFFERED MIXERS AND REMOTE VALVE SWITCHING FOR MICROFLUIDIC DEVICES
The present invention relates generally to the control of fluid flow rate and direction on a microfluidic device. In particular, the present invention provides an integrated valveless microfluidic...
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US20120077182 |
ADDITIVE SOLUTION FOR BLOOD PRESERVATION
A method for the storage of red blood cells provides for mixing an additive solution with packed red blood cells to create a suspension of red blood cells. The method further provides for reducing...
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8137509 |
Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral brønsted acids
The present invention provides a new strategies for the synthesis of compounds of the rocaglamide family and related natural products. The synthetic approach generally involves photochemical...
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US20120040869 |
SEQUENCE PRESERVED DNA CONVERSION
Described herein are inexpensive high throughput methods to convert a target single stranded DNA (ssDNA) such that each nucleotide (or base) adenine (A), thymine (T), guanine (G) and cytosine (C)...
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US20120028838 |
Quantification of Gene Expression
The present invention relates to a method for measuring the amount of a target nucleic acid in a sample using a standard which is designed to have one base difference compared with the gene of...
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8093417 |
Lipoxin analogs and methods for the treatment of periodontal disease
This invention provides new lipoxin analogs, compositions containing analogs, and methods of using these compounds and compositions for treating and preventing oral inflammation, including...
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8093288 |
Genipin derivatives and uses thereof
Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin...
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US20120003630 |
MODULAR NUCLEIC ACID-BASED CIRCUITS FOR COUNTERS, BINARY OPERATIONS, MEMORY, AND LOGIC
We have created novel engineered genetic counter designs and methods of use thereof that utilize DNA recombinases to provide modular systems, termed single invertase memory modules (SIMMs), for...
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US20110313145 |
ISOLATION OF RNA
Disclosed herein are methods for purification of RNA from a sample. The RNA can be total RNA or mRNA. The method involves preparing the sample in a solution of lysis buffer and depositing into a...
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8071282 |
Method of storing red blood cells with an acidic additive solution under oxygen depletion
There is provided compositions and methods for the storage of red blood cells. The compositions are additive solutions comprising adenine, dextrose, mannitol, NaH2PO4, and optionally NaCl and/or...
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US20110285991 |
CHEMICAL/BIOLOGICAL SENSOR EMPLOYING SCATTERED CHROMATIC COMPONENTS IN NANO-PATTERNED APERIODIC SURFACES
A label-free multiplexed sensing platform is based on light interaction with aperiodic photonic structures with an advantage of a broadband operation. Multiple-scattering-induced...
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8063535 |
Nanomechanical oscillator
A mechanical oscillator has components with dimensions in a sub-micron range to produce resonance mode oscillations in a gigahertz range. A major element is coupled to a minor, sub-micron element...
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US20110267614 |
ENGINEERED SERS SUBSTRATES EMPLOYING NANOPARTICLE CLUSTER ARRAYS WITH MULTISCALE SIGNAL ENHANCEMENT
Defined nanoparticle cluster arrays (NCAs) with total lateral dimensions of up to 25.4 μm by 25.4 μm have been fabricated on top of a 10 nm thin gold film using template guided self-assembly. T...
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US20110251149 |
METHODS AND LOW DOSE REGIMENS FOR TREATING RED BLOOD CELL DISORDERS
Disclosed herein are methods and low dose regimens for increasing fetal hemoglobin levels in patients with red blood cell disorders, such as beta thalassemia, sickle cell disease, other anemias, or...
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8035113 |
Optical devices featuring textured semiconductor layers
A semiconductor sensor, solar cell or emitter, or a precursor therefor, has a substrate and one or more textured semiconductor layers deposited onto the substrate. The textured layers enhance light...
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8034567 |
Quantification of gene expression
The present invention relates to a method for measuring the amount of a target nucleic acid in a sample using a standard which is designed to have one base difference compared with the gene of...
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US20110245154 |
Methods and Compositions for Treating Viral or Virally-Induced Conditions
Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a...
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US20110244451 |
Methods for prenatal diagnosis of chromosomal abnormalities
Chromosomal abnormalities are responsible for a significant number of birth defects, including mental retardation. The present invention is related to methods for non-invasive and rapid, prenatal...
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US20110243883 |
POLYMERIC BIOLUBRICANTS FOR MEDICAL USE
The present invention provides branched polymers which can be used as lubricants or shock absorbers in vivo. For example, the inventive polymers can be used as viscosupplements, viscoelastics,...
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US20110237654 |
METHOD TO INHIBIT CELL GROWTH USING OLIGONUCLEOTIDES
Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more...
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US20110236966 |
SINGLE LENTIVIRAL VECTOR SYSTEM FOR INDUCED PLURIPOTENT (IPS) STEM CELLS DERIVATION
The present invention is based on the discovery that a single lentiviral vector expressing multiple individual transcription factor proteins from a single multi-cistronic mRNA can reprogram a...
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US20110217328 |
COMPOSITIONS AND METHODS FOR TREATING EBOLA VIRUS INFECTION
The compositions and methods of the invention described herein provide treatments against Ebola virus infection by expressing gene(s) from the Ivory Coast ebolavirus (ICEBOV) species in a...
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US20110207679 |
METHODS OF TREATMENT USING IL-16 ANTAGONIST PEPTIDES
The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The...
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US20110201667 |
COMPOSITIONS AND METHODS FOR SILENCING EBOLA VIRUS GENE EXPRESSION
The present invention provides compositions comprising therapeutic nucleic acids (e.g., interfering RNA such as siRNA) that target Ebola virus (EBOV) gene expression and methods of using such...
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7999095 |
Nucleic acid supported protein complementation
The present invention is directed to novel methods for in vitro and in vivo detection of target nucleic acid molecules, including DNA and RNA targets, as well as nucleic acid analogues. The present...
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US20110191871 |
METHODS TO IDENTIFY FACTORS ASSOCIATED WITH MUSCLE GROWTH AND USES THEREOF
The present invention relates to methods to identify factors associated with muscle growth, angiogenesis, obesity, insulin sensitivity body weight, fat mass, muscle mass and cardiovascular...
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US20110187297 |
SWITCHING DEVICES AND RELATED METHODS
A mechanical device capable of switching between two states is described. The device may include a micromechanical resonator with two distinct states in the hysteretic nonlinear regime. The devices...
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US20110177534 |
DIAGNOSTICS FOR MEMBRANOUS NEPHROPATHY
The invention relates to immunoassays, reagents, therapeutics and methods of diagnosing and prognosis evaluation of idiopathic membranous nephropathy (MN). Immunoassays comprise enzyme-linked...
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US20110172785 |
COMPLIANT COMPOSITES FOR APPLICATION OF DRUG-ELUTING COATINGS TO TISSUE SURFACES
A compliant composite for delivering a bioactive agent including a scaffolding material and a polymer coating that together can be attached to compliant tissue surfaces is disclosed, along with...
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US20110172753 |
ENDOPROSTHESES
Endoprosthesis are disclosed.
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7976936 |
Endoprostheses
Endoprostheses are disclosed.
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US20110158909 |
Cationic Contrast Agents and Methods of Use Thereof
The present invention provides compounds useful as contrast agents, such as for the CT imaging of cartilage tissue. The contrast agents are generally iodinated organic molecules that are positively...
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US20110152305 |
FILMS AND PARTICLES
Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.
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US20110142821 |
ROLES FOR DUAL ENDOTHELIN-1/ANGIOTENSIN II RECEPTOR (DEAR) IN HYPERTENSION AND ANGIOGENESIS
The present application is directed to the identification of mutations and/or polymorphisms in the Dual Endothelin-1/Angiotensin II Receptor (Dear) that indicate susceptibility to, or show current...
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US20110135716 |
DELIVERY OF H2 ANTAGONISTS
The present invention provides improved systems and methods for the local delivery of H2 antagonists. The inventive methods include topical administration of an effective amount of a H2 antagonist...
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US20110129878 |
BIOREACTIVE AGENTS
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily...
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US20110123526 |
METHODS AND COMPOSITIONS FOR PREVENTING ADHESION
This invention provides methods and compositions for preventing post-surgical adhesion formation based on use of an interleukin-16 (IL-16) antagonist, including an IL-16 antagonist peptide and/or...
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US20110119259 |
NETWORK BIOLOGY APPROACH FOR IDENTIFYING TARGETS FOR COMBINATION THERAPIES
Described herein is a network biology approach useful for the identification of multiple therapeutic targets, which can be targeted simultaneously using an agent (or a plurality of agents) to...
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US20110109736 |
System and Method for Producing an Optically Sectioned Image Using Both Structured and Uniform Illumination
A first image data set of the real-world object is received at a processor where the real-world object was illuminated with substantially uniform illumination. A second image data set of the...
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US20110106049 |
FULLY AUTOMATED CONTROL SYSTEM FOR TYPE 1 DIABETES
An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with...
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