Patents and Patent Applications from Boston University Boston Medical Center


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10024723 Detection of electromagnetic radiation using nonlinear materials  
An apparatus for detecting electromagnetic radiation within a target frequency range is provided. The apparatus includes a substrate and one or more resonator structures disposed on the substrate....
US20180198167 IONIC LIQUID ELECTROLYTES AND ELECTROCHEMICAL DEVICES COMPRISING SAME  
The present disclosure provides novel ionic liquids with favorable thermal and electrochemical properties. Also provided are devices incorporating the ionic liquids, such as Lithium-ion batteries...
US20180192936 SYSTEM AND METHODS FOR MONITORING AND IMPROVING COGNITIVE FLEXIBILITY  
A system and methods for monitoring and controlling a mental state of a subject are provided. In some aspects, a method includes receiving physiological and behavioral data acquired using the...
10018817 Adaptive optics for imaging through highly scattering media in oil reservoir applications  
Embodiments of the invention provide an imaging system and method using adaptive optics and optimization algorithms for imaging through highly scattering media in oil reservoir applications and...
US20180185345 METHODS AND COMPOSITIONS FOR TREATING HERPESVIRUS INDUCED CONDITIONS  
Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a...
10011875 Methods and assays relating to Huntingtons disease and Parkinson's disease  
Described herein are methods for the diagnosis, prognosis, and treatment of neurological conditions, e.g. Huntington's Disease, relating to the misregulation of miRNAs in such conditions.
10004800 Antibody evolution immunogens  
The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the...
10004695 GM3 functionalized nanoparticles  
Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles...
US20180171418 DIAGNOSTIC FOR LUNG DISORDERS USING CLASS PREDICTION  
The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with...
US20180163195 INDUCIBLE DIMERIZATION OF RECOMBINASES  
The technology described herein relates to controlled chemically- or light-induced rejoinder of split-recombinases. In some embodiments, compositions, methods, kits and systems are provided that...
US20180160917 A DEVICE AND METHOD FOR NON-INVASIVE LEFT VENTRICULAR END DIASTOLIC PRESSURE (LVEDP) MEASUREMENT  
The present application relates to systems and methods for non-invasively determining at least one of left ventricular end diastolic pressure (LVEDP) or pulmonary capillary wedge pressure (PCWP)...
9993577 Dissolvable hydrogel compositions for wound management and methods of use  
The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving...
US20180155758 METHOD AND DEVICE FOR ANTIBIOTIC SUSCEPTIBILITY TESTING BASED ON FLUCTUATIONS OF ELECTRICAL RESISTANCE IN A MICROCHANNEL  
A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing...
9987346 Methods and compositions for vaccinating a subject for a sexually transmitted pathogen  
Purified Chlamydia major outer membrane protein (MOMP) has been observed to induce protection against genital and respiratory challenge in mice. MOMP contains variable domains that are highly...
9983260 Dual-phase interferometry for charge modulation mapping in ICS  
A dual-phase interferometric method and device for charge modulation mapping in integrated circuits provides significant improvement in signal to noise ratio over conventional detection...
US20180142247 CIS/TRANS RIBOREGULATORS  
The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate...
9979038 System and method for energy storage and recovery  
System and method for energy storage and recovery is described. More particularly, system and method using tungsten based materials to electrochemically store and recover energy is described. In...
US20180137690 MATERIAL ANALYSIS OF ANATOMICAL ITEMS  
A computer-implemented method for medical device modeling includes accessing an electronic definition for a model of a three-dimensional item and an electronic definition of a three-dimensional...
US20180128947 SERS SYSTEM EMPLOYING NANOPARTICLE CLUSTER ARRAYS WITH MULTISCALE SIGNAL ENHANCEMENT  
Defined nanoparticle cluster arrays (NCAs) with dimensions up to 25.4 μm square are fabricated on a 10 nm gold film using template guided self-assembly. Structural parameters are precisely...
US20180127447 METATHESIS CATALYSTS AND METHODS THEREOF  
The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with...
US20180117296 INFUSION SYSTEM AND COMPONENTS THEREOF  
Certain embodiments provide multi-medicament infusion systems for preventing the cross-channeling of medicaments. The system may include one or more of an infusion pump, medicament reservoirs,...
9957511 Functionalization of endogenous bacteria  
Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous...
US20180110404 RETRACTABLE ENDOSCOPIC SUCTION TUBE  
Disclosed herein is an aspiration assembly for attaching to an endoscope. The aspiration assembly comprises an extendable suction tube for aspirating an object (e.g., smoke, blood, blood clot,...
US20180108342 LOW-DIMENSIONAL REAL-TIME CONCATENATIVE SPEECH SYNTHESIZER  
A method of providing real-time speech synthesis based on user input includes presenting a graphical user interface having a low-dimensional representation of a multidimensional phoneme space, a...
US20180099072 INJECTABLE TISSUE SUPPLEMENT  
The present invention provides polymers which can be used as tissue supplements or lubricants in vivo. The inventive polymers can be used as tissue-interpenetrating hydrogel supplements,...
9927350 Thermal property microscopy with frequency domain thermoreflectance and uses thereof  
The present invention relates to frequency domain thermoreflectance (FDTR) imaging of a thermophysical property or a set of thermophysical properties of a sample. A method comprises measuring the...
9920374 Diagnostic for lung disorders using class prediction  
The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis with...
9919009 Production of red blood cells and platelets from stem cells  
This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a stem cell into a MEP in culture in the presence of an aryl hydrocarbon...
9913862 Methods of treating gram-negative microbial infections  
Provided herein are methods and compositions for treatment of a microbial infection or a microbial biofilm in a subject or on a surface by administering to the subject or surface determined to...
US20180057838 SYNTHETIC TRANSCRIPTIONAL AND EPIGENETIC REGULATORS BASED ON ENGINEERED, ORTHOGONAL ZINC FINGER PROTEINS  
Embodiments disclosed herein provide artificial expression systems comprising the zinc-finger containing transcription factors and engineered promoters to modulate expression of genes of interest....
9903820 Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof  
Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof. Nanopores are extremely sensitive single-molecule sensors. Recently, electron beams have been used...
US20180051311 METHOD AND DEVICE FOR ANTIBIOTIC SUSCEPTIBILITY TESTING BASED ON FLUCTUATIONS OF ELECTRICAL RESISTANCE IN A MICROCHANNEL  
A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing...
US20180051277 PROTECTION OF BARCODES DURING DNA AMPLIFICATION USING MOLECULAR HAIRPINS  
Described herein are approaches for the improved detection, identification, and/or quantification of target nucleic acids. These approaches provide a means of detecting, identifying, and/or...
US20180051033 INHIBITORS OF LATE SV40 FACTOR (LSF) AS CANCER CHEMOTHERAPEUTICS  
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a...
9896660 Production of red blood cells and platelets from stem cells  
This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a MEP precursor cell into a MEP in culture in the presence of an aryl...
US20180043066 MACROINITIATORS FOR HYDROPHILIC COATINGS ON LATEX AND APPLICATIONS THEREOF  
Provided herein are methods comprising the use of a macroinitiator and application protocols to apply a hydrophilic coating to latex, or natural rubber, and compositions resulting from such...
US20180030412 AGE-ASSOCIATED CLONAL HEMATOPOIESIS ACCELERATES CARDIO-METABOLIC DISEASE DEVELOPMENT  
As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in TET2 leads to pro-inflammatory IL-1β signaling at multiple levels,...
US20180028683 THERANOSTIC COMPOSITIONS AND USES THEREOF  
Provided herein are theranostic compositions comprising a Janus nanoparticle-coated microbubble that are useful for imaging (e.g., MRI, or ultrasound) and for delivering a therapeutic or bioactive...
US20180023211 NANOPARTICLE DEPOSITION IN POROUS AND ON PLANAR SUBSTRATES  
A method of preparing a metal nanoparticle on a surface includes subjecting a metal source to a temperature and a pressure in a carrier gas selected to provide a vapor metal species at a vapor...
9872936 Injectable tissue supplement  
The present invention provides polymers which can be used as tissue supplements or lubricants in vivo. The inventive polymers can be used as tissue-interpenetrating hydrogel supplements,...
US20180010197 GENE EXPRESSION-BASED BIOMARKER FOR THE DETECTION AND MONITORING OF BRONCHIAL PREMALIGNANT LESIONS  
Disclosed herein are assays and methods for the identification of premalignant lesions, as well as methods of determining the likelihood that such premalignant lesions will progress to lung...
US20180009685 Method and Composition For Reducing Nitrates, Nitrites, and/or Hydroxylamine in Water Using a Homogeneous Reduced Copper Tetra-Substituted Fluorinated Pinacolate Ligand Catalyst Complex  
A method for reducing nitrates, nitrites, and/or hydroxylamine in water using a homogeneous reduced copper tetra-substituted fluorinated pinacolate ligand catalyst complex. The method includes...
9865096 Material analysis of anatomical items  
A computer-implemented method for medical device modeling includes accessing an electronic definition for a model of a three-dimensional item and an electronic definition of a three-dimensional...
US20180003851 WIRELESS FLUIDIC READOUT PLATFORM FOR SENSORS  
Near-field magnetic resonance is used to retrieve information stored in sensors passing through a fluidic channel in a fluidic medium, and can also be used for recharging a power source in the...
US20170369643 GLYCEROL-BASED POLYCARBONATES  
The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for drug delivery, biodegradable consumer plastics, or solvents for Li-based batteries or...
US20170369591 PREDICTIVE MARKER FOR TOPOISOMERASE I INHIBITORS  
The present invention generally relates to the fields of cancer therapy and cancer prevention. More particularly, the present invention generally relates to a diagnostic marker for predicting the...
US20170367820 PULMONARY-SYSTEMIC SHUNT DEVICES AND RELATED METHODS  
A method for treating a patient may include establishing an anastomosis between a pulmonary artery and an aorta; and pumping blood from the pulmonary artery to the aorta when the pulmonary artery...
9850268 Metathesis catalysts and methods thereof  
The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with...
US20170363582 METHOD AND SYSTEM FOR OBLIQUE BACKSCATTERING ULTRASOUND IMAGING  
An Oblique Backscatter Ultrasound imaging system includes a transceiver that has an US source and a plurality of US detectors configured in receive signals off axis from the US source. While the...
US20170357853 Large Scale Video Search Using Queries that Define Relationships Between Objects  
One embodiment of the present solution is a relationship-based video server system. The server system is programmed to provide a platform for large scale video search based on relationships...