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6124129 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Compositions and methods for controlling genetically engineered organisms
Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal...
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6123768 |
Method for the preparation and doping of highly insulating monocrystalline gallium nitride thin films
This invention relates to a method of preparing highly insulating GaN single crystal films in a molecular beam epitaxial growth chamber. A single crystal substrate is provided with the appropriate...
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6106481 |
Method and apparatus for enhancing patient compliance during inspiration measurements
A system for measuring a patient's inspiration volume and for enhancing patient compliance with a predetermined breathing pattern during inspiration volume measurements. A flexible conductive loop...
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6103689 |
Methods of inducing hair growth and coloration
A method for maintaining hair growth and coloration in humans by using neurotrophin ligands to prevent p75 nerve growth factor (NGF) receptor mediated apoptosis in melanocytes and keratinocytes is...
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6096276 |
Apparatus for effecting sequential chemical syntheses
Apparatus for effecting sequential chemical synthesis of a plurality of products on solid supports. A reactor is provided having a movable rotor section including a plurality of reactor modules...
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6090953 |
Pyronin antibacterials, process and novel intermediates thereto
The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel...
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6083941 |
Inhibition of NMDA receptor activity by pregnenolone sulfate derivatives
The present invention relates to a method of inhibiting N-methyl-D-aspartate (NMDA) glutamate receptor-mediated ion channel activity (NMDA receptor activity), comprising contacting a neuronal cell...
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6066726 |
Neuron-specific transcriptional promoter
The 5'-flanking region and core regulatory domains that underlie neuronal specific expression of the human γ-aminobutyric acid type A (GABAA) receptor β1 subunit gene are identified herein. S...
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6057096 |
Photocleavable agents and conjugates for the detection and isolation of biomolecules
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily...
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6048722 |
Cellular physiology workstations for automated data acquisition and perfusion control
Cellular physiology workstations for automated data acquisition and perfusion control are described. The cellular physiology workstation may be used for physiological and electrophysiological...
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6032074 |
Method and apparatus for improving the function of sensory cells
A method and system for enhancing the function of sensory cells. The method includes locating a sensory cell area associated with the sensory cell whose function is to be enhanced, and inputting a...
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6022983 |
Pyronin antibacterials, process and novel intermediates thereto
The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel...
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6022951 |
Streptavidin mutants
The present invention relates to streptavidin proteins and peptides having a altered physical properties such as an increased stability or increased or decreased affinity for binding biotin. The...
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6007987 |
Positional sequencing by hybridization
This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods...
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6004750 |
Nucleic acid clamps
The invention relates to nucleic acid clamps and methods for using nucleic acid clamps, for example, to inhibit gene expression or cleavage, or to specifically cleave a target nucleic acid. Nucleic...
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5999954 |
Low-power digital filtering utilizing adaptive approximate filtering
A method of digital filtering and a digital filter having a filter response with a predetermined filter order. The filter response produces a predetermined set of filtered output samples defining...
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5986111 |
Pyronin antibacterials, process and novel intermediates thereto
The present invention provides convergent processes for preparing myxopyronins and corallopyronins, compounds useful as antibacterial therapeutics. The present invention also provides novel...
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5986076 |
Photocleavable agents and conjugates for the detection and isolation of biomolecules
This invention relates to agents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily...
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5984954 |
Methods and apparatus for R-wave detection
Apparatus and methods for determining the precise times of occurrence of R-waves in an ECG signal of a patient. Samples of the patient's ECG signal are accumulated and an ECG window comprising a...
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5976817 |
Diagnostic method for detecting Alzheimer's disease in living patients
Upon activation, platelet α-granules' soluble contents are secreted and membrane-bound contents are translocated to the plasma membrane. Membrane-bound proteins include the β-amyloid precursor p...
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5976345 |
Method and apparatus for metal extraction and sensor device related thereto
An amperometric in situ apparatus and technique for measuring the concentrations and transport properties of easily dissociable oxides in slags is described. The technique consists of a combination...
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5965133 |
Self-assembling multimeric nucleic acid constructs
The invention is directed to constructs and compositions containing multimeric forms of nucleic acid. Multimeric nucleic acids comprise single-stranded nucleic acids attached via biotin to...
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5962417 |
Methods of modulating melanin synthesis
Methods are described whereby vertebrate skin, hair, wool or fur may be lightened, or darkened, in color by administration of a substance, e.g., peptide, antibody, antibody fragment or DNA sequence...
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5955749 |
Light emitting device utilizing a periodic dielectric structure
A light emitting device comprising a substrate and a dielectric structure having at least a two-dimensionally periodic variation of dielectric constant which exhibits a spectrum of electromagnetic...
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5955059 |
Use of locally applied DNA fragments
Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, vitiligo, atopic dermatitis, or hyperproliferative or...
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5954661 |
Tissue characterization and treatment using pacing
Heart tissue is characterized by using pacing without inducing ventricular tachycardia (VT). With the tissue characterization, a patient's risk of developing VT can be determined and a slow...
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5932899 |
Semiconductor having enhanced acceptor activation
A semiconductor having enhanced acceptor activation is disclosed. The semiconductor comprises a ternary compound having a non-abruptly varying composition that is uniformly doped. The modulation of...
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5932471 |
DNA encoding chimeric toxin
A chimeric toxin comprising protein fragments joined together by peptide bonds, the chimeric toxin comprising, in sequential order, beginning at the amino terminal end of the chimeric toxin, (a)...
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5922858 |
Method for the detection and isolation of protein
The invention is directed to methods for the non-radioactive labeling, detection, quantitation and isolation of nascent proteins translated in a cellular or cell-free translation system. tRNA...
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5912230 |
Anti-fungal and anti-bacterial histatin-based peptides
Histatin-based peptides representing defined portions of the amino acid sequences of naturally occurring human histatins and methods for treatment of fungal or bacterial infection are described....
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5897696 |
Radio-opaque paint for medical stents
A process for preparing a water-soluble, radio-opaque paint for marking acrylic resin dental stents includes the steps of preparing a solution comprising 50 ml of ethanol, 6.4 grams of glycerol;...
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5888996 |
Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
The present invention relates to a method of inhibiting N-methyl-D-aspartate (NMDA) glutamate receptor-mediated ion channel activity (NMDA receptor activity), comprising contacting a neuronal cell...
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5885965 |
Anti-fungal D-amino acid histatin-based peptides
D-amino acid histatins and histatin-based peptides and methods for treatment of fungal or bacterial infection are described. These D-amino acid histatins and histatin-based peptides are...
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5877009 |
Isolated ApoA-I gene regulatory sequence elements
The present invention provides isolated apolipoprotein transcription factors and gene regulatory elements. The invention also provides methods of modulating apolipoprotein gene expression by...
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5863891 |
Chimeric toxins
A chimeric toxin comprising protein fragments joined together by peptide bonds, the chimeric toxin comprising, in sequential order, beginning at the amino terminal end of the chimeric toxin,(a) the...
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5862269 |
Apparatus and method for rapidly convergent parallel processed deconvolution
An image processing system and method which may be used for standalone deconvolution or, alternatively, may be employed as a staring point for very rapid convergence with subsequent use of prior...
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5858365 |
Methods for the treatment of wounds using butyric acid salts and derivatives
This invention is directed to methods of administering physiologically stable and safe compositions of butyric acid salts and derivatives to a patient for the purpose of wound healing.
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5849560 |
Proteases causing degradation of amyloid β-protein precursor
A proteolytic factor has been isolated from the brains of humans with Alzheimer's disease which specifically cleaves the peptide having the sequence His-Ser-Glu-Val-Lys-Met-Asp-Ala-Glu-Phe (SEQ ID...
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5847397 |
Photodetectors using III-V nitrides
A bandpass photodetector using a III-V nitride and having predetermined electrical properties. The bandpass photodetector detects electromagnetic radiation between a lower transition wavelength and...
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5843348 |
Method for fabricating odontoforms and dental restorations having infused ceramic network
A process for producing a ceramic network material from a ceramic suspension includes casting a suspension in a tooth-shaped mold. The suspension includes dispersed alumina particles in a medium...
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5836974 |
Real-time and adaptive method and system for suppressing a pathological non-chaotic rhythm
Low-dimensional real-world chaotic or non-chaotic dynamical systems are controlled by a model-independent control technique that does not require knowledge of the system's governing equations or a...
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5821633 |
Center of weight sensor
A sensor system preferably for use in a vehicle airbag deployment system employs spatial shading techniques and centroiding analysis to calculate an equivalent point load in two dimensional space....
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5797623 |
Smart skin sensor for real-time side impact detection and off-line diagnostics
A low cost, high bandwidth "smart skin" impact sensor is developed for application to vehicle side impact detection and diagnostics. The sensor is based on a piezo polymer smart skin technology and...
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5796477 |
Entangled-photon microscopy, spectroscopy, and display
The present invention relates to novel entangled-photon microscopy, spectroscopy and display systems. The systems include a source of light in the form of twin or multiple entangled-photon beams....
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5795714 |
Method for replicating an array of nucleic acid probes
The invention relates to the replication of probe arrays and methods for replicating arrays of probes which are useful for the large scale manufacture of diagnostic aids used to screen biological...
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5789208 |
Polyclonal antibody libraries
The invention is directed to methods for the creation and use of libraries of proteins which comprise polyclonal antibodies to a common antigen or group of antigens, receptor proteins with related...
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5784492 |
Apparatus and method for data compression with the CLEAN technique
A method and system for deconvolution derived from the CLEAN technique. The nonlinear CLEAN method, combined with a priori knowledge of the point spread function allows for extraction and...
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5783371 |
Process for manufacturing optical data storage disk stamper
A process for manufacturing an optical data storage disk stamper includes the steps of providing an amorphous electroless nickel substrate including phosphorous in the amount in a range of about 5...
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5782873 |
Method and apparatus for improving the function of sensory cells
Method and system for enhancing the function of sensory cells are disclosed. The method comprises locating a sensory cell area associated with the sensory cell whose function is to be enhanced and...
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5767507 |
Polarization sensitive photodetectors and detector arrays
A device for detecting polarization of light comprising a first photodetector tuned to absorb TE polarization, a second photodetector tuned to absorb TM polarization, and a circuit for comparing an...
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