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7635484 |
BoNT/A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy
The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides.
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7622252 |
Generation of minicircle DNA with physiological supercoiling
Methods for the production of supercoiled DNA minicircles and their use as substrates are described herein.
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US20090269753 |
GENOTYPING FOR SRC-1 PREDICTS FOR BONE LOSS
Osteoporosis is a common skeletal disease characterized by loss of bone mineral density (BMD) and increased risk of fracture. Osteoporosis most commonly occurs in postmenopausal women due to...
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US20090256069 |
APPARATUS FOR DESORPTION AND IONIZATION OF ANALYTES
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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7601806 |
RTVP-GliPR-like compositions and methods for the detection, treatment and prevention of prostate cancer
The invention is directed to purified and isolated novel RGL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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US20090219607 |
METHOD AND APPARATUS FOR ENHANCED RESOLUTION MICROSCOPY OF LIVING BIOLOGICAL NANOSTRUCTURES
The present invention is a method and apparatus that utilizes an inertia-free diffraction mechanism to control both phase and rotation of the standing wave pattern that results in super-resolution...
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7582478 |
Cleaved serum response factor in cardiac diagnosis and therapy
The present invention is directed to the cleavage of serum response factor as it relates to cardiac disease. In specific embodiments, failing cardiac tissue is diagnosed in tissues comprising...
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US20090215648 |
Rapid subcloning using site-specific recombination
The present invention provides compositions, including vectors, and methods for the rapid subcloning of nucleic acid sequences in vivo and in vitro. In particular, the invention provides vectors...
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US20090215147 |
Use of Mutant Herpes Simplex Virus-2 for Cancer Therapy
The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity,...
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7579326 |
Gene switch systems employing regulators with decreased dimerization
Disclosed is a novel inducible expression system characterized by undetectable biological effect in the absence of an inducer, but which exhibits efficient inducibility in the presence of an inducer.
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US20090202108 |
ASSAYING AND IMAGING SYSTEM IDENTIFYING TRAITS OF BIOLOGICAL SPECIMENS
A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points...
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US20090200341 |
Adjustable-Volume Liquid Dispensing Pump
An adjustable-volume liquid dispenser is disclosed. In one embodiment, an adjustable-volume liquid dispenser includes a spout and a plunger secured to the spout. The dispenser further includes a...
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US20090170748 |
Plasmid mediated supplementation for treating chronically ill subjects
The present invention pertains to compositions and methods for plasmid-mediated supplementation. The compositions and methods are useful for treating anemia and other effects that are commonly...
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RE40789 |
Mammalian checkpoint proteins polypeptides and encoding sequences thereof
The present invention relates to the isolation of gene sequences encoding mammalian cell cycle checkpoints, as well as the expression of the encoded proteins using recombinant DNA technology. The...
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US20090157122 |
BONE COMPRESSION DEVICE
The invention relates to bone compression devices and bone compression systems, and in particular, to bone compression devices and systems for use in connection with vertebrae. The bone compression...
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7537899 |
Defects in periaxin associated with myelinopathies
The present invention relates to defects in periaxin (PRX) associated with myelinopathies, including Charcot-Marie-Tooth syndrome and/or Dejerine-Sottas syndrome. Unrelated individuals having a...
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US20090131475 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS
The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog thereof. In other aspects, the compound for...
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US20090123501 |
INHIBITION OF THE SH2-DOMAIN CONTAINING PROTEIN TYR-PHOSPHATASE, SHP-1, TO ENHANCE VACCINES
The invention describes the use of dendritic cell vaccines, wherein SHP-1 expression or activity is modulated in the dendritic cell. In particular, the invention provides dendritic cells (DC)...
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7511811 |
Pulsed-multiline excitation for color-blind fluorescence detection
The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput...
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US20090075928 |
G-QUARTET OLIGONUCLEOTIDES THAT TARGET HYPOXIA-INDUCIBLE FACTOR 1-a (HIF1a )
The present invention concerns particular G-quartet oligonucleotides that are employed for the treatment and/or prevention of cancer. In specific cases, the G-quartet oligonucleotides inhibit HIF-1α.
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US20090062620 |
Methods for Estimating the Metabolic Cost of Walking
Methods for determining the metabolic cost for walking are disclosed. In one embodiment, a method for determining metabolic cost per unit time of a walk by an individual is disclosed. The method...
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7491549 |
Apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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US20090042205 |
FLUORESCENCE DETECTION OF DNA BREAKS USING MOLECULAR OSCILLATORS
A method to detect DNA breaks includes providing a mixture of fluorescence energy transfer molecular oscillators and a DNA sample. The FET oscillator is a synthetic oligonucleotide that has a...
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US20090029930 |
Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter
The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting...
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7470673 |
Composition and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis and abnormal cell proliferation
Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation...
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US20080311140 |
Antigen specific immunosuppression by dendritic cell therapy
The invention includes genetically modified dendritic cells expressing at least two immunosuppressive molecules. The genetically modified dendritic cells have the ability to induce tolerance....
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US20080311135 |
IMMUNE COMPLEX VACCINATION AS A STRATEGY TO ENHANCE IMMUNITY IN THE ELDERLY AND OTHER IMMUNE COMPROMISED POPULATIONS
The present invention generally concerns methods and compositions for improving the immune system of an individual that is an immune-compromised individual. In particular aspects, the...
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7462699 |
BoNT/A peptides and methods of predicting and reducing immunoresistance to botulinum toxin therapy
The present invention provides BoNT/A peptides as well as methods of predicting or determining immunoresistance to botulinum toxin therapy in an individual using BoNT/A peptides.
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7462491 |
Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin
Serum cav-1 is disclosed as a biomarker for prostate cancer that has the power to differentiate between prostate cancer and BPH patients.
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7452345 |
Anti-infective endotracheal tube
A multi-lumen endotracheal tube has means for coating an inside and an outside surface of the endotracheal tube with antimicrobial and antibiofilm agents; means for releasing antimicrobial and...
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7449561 |
Alterations in the dystrophin gene associated with sporadic dilated cardiomyopathy
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to detect a human sporadic DCM predisposing gene,...
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7449480 |
Small molecule inhibitors of HER2 expression
Peptide mimetic small molecule inhibitors of Sur-2 are provided having the general formula:
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7449150 |
Probe and apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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7442688 |
Composition and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis and abnormal cell proliferation
Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation...
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7429650 |
Methods and compositions in breast cancer diagnosis and therapeutics
The present invention is directed to compositions regarding a specific mutation in estrogen receptor alpha and their use as diagnostic markers in breast tissue, such as premalignant lesions, for...
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US20080226609 |
Transplantation of Glial Restricted Precursor-Derived Astrocytes for Promotion of Axon Growth
Provided herein are compositions and methods for the treatment of central nervous system (CNS) lesions comprising administration of glial restricted precursor (GRP) derived astrocytes (GDAs).
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7419785 |
Methods and compositions in breast cancer diagnosis and therapeutics
The present invention is directed to compositions regarding a specific mutation in estrogen receptor alpha and their use as diagnostic markers in breast tissue, such as premalignant lesions, for...
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US20080207543 |
MODIFIED PITUITARY GLAND DEVELOPMENT IN OFFSPRING FROM EXPECTANT MOTHER ANIMALS TREATED WITH GROWTH HORMONE RELEASING HORMONE THERAPY
The intramuscular electroporated injection of a protease-resistant growth hormone-releasing hormone (“GHRH”) cDNA into rat dams at 16 days of gestation resulted in the enhanced long-term growth...
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7413909 |
Method and apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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US20080195612 |
Application package to automatically identify some single stranded RNA viruses from characteristic residues of capsid protein or nucleotide sequences
A system implemented on a computer is disclosed for automatically identifying strains of partial or complete capsid sequences of picoma and caliciviruses, two of the most highly diverse ssRNA virus...
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7404950 |
Induced activation in dendritic cell
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
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7402402 |
P38 MAPK pathway predicts endocrine-resistant growth of human breast cancer and provides a novel diagnostic and treatment target
Acquired and de novo endocrine resistance are major clinical problems in the management of breast cancer patients. Though the antiestrogen tamoxifen prolongs disease-free and overall survival in...
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US20080138844 |
Methods For Diagnosis And Monitoring Of Neurological Disease By Detection Of An Encephalotoxin
Encephalotoxin produced by activated mononuclear phagocytes is present in individuals having neurological disease including neurodegenerative and neuro-inflammatory diseases, such as Alzheimer's...
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US20080081780 |
IDENTIFICATION OF OLIGOADENYLATE SYNTHETASE-LIKE GENES
The present invention relates to compositions and methods for modulating conception in animals. More particularly, the composition modulates mRNA degradation during gametogenesis and early...
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7344853 |
Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin
Encephalotoxin produced by activated mononuclear phagocytes is present in individuals having neurological disease including neurodegenerative and neuro-inflammatory diseases, such as Alzheimer's...
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US20080064954 |
METHOD OF MEASURING PROPULSION IN LYMPHATIC STRUCTURES
Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy...
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US20080056999 |
IMAGING AGENTS FOR FUNCTIONAL IMAGING OF LYMPHATIC STRUCTURES
Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid...
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7338800 |
In vivo gene transfer
The present invention is directed to an in vivo method of transferring DNA from a donor cell to a recipient cell. In a specific embodiment, the method comprises a highly efficient process of...
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7338656 |
Composition and method to alter lean body mass and bone properties in a subject
A method for decreasing the body fat proportion, increasing lean body mass, increasing bone density, or improving the rate of bone healing, or all, of a subject. Embodiments of the invention...
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US20080050316 |
MOLECULAR IMAGING OF EPITHELIAL CELLS IN LYMPH
Methods and imaging agents for imaging epithelial cancer cells in the lymphatic system are disclosed herein. In an embodiment, an imaging agent for imaging cancer cells in a lymphatic system...
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