Patents and Patent Applications from Baylor College of Medicine


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US20180265444 SMALL MOLECULE STIMULATORS OF STEROID RECEPTOR COACTIVATOR PROTEINS AND THEIR USE IN THE TREATMENT OF CANCER  
Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for...
US20180264040 NKT-CELL SUBSET FOR IN VIVO PERSISTENCE AND THERAPEUTIC ACTIVITY AND PROPAGATION OF SAME  
Embodiments of the disclosure include methods and compositions for producing NKT cells effective for immunotherapy and also methods and compositions for providing an effective amount of NKT cells...
US20180251568 CSGP4 - SPECIFIC CHIMERIC ANTIGEN RECEPTOR FOR CANCER  
Embodiments of the disclosure include methods and compositions related to chimeric antigen receptors (CAR) that target chondroitin sulfate proteoglycan-4 (CSPG4). T cells transduced with a...
US20180250384 IMMUNOGENIC ANTIGEN IDENTIFICATION FROM A PATHOGEN AND CORRELATION TO CLINICAL EFFICACY  
Embodiments of the disclosure concern methods of identifying whether or not antigens from a particular pathogen are immunogenic, including the order of their immunogenicity. Other embodiments...
US20180250379 GENERATION OF HPV-SPECIFIC T-CELLS  
Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern...
US20180245079 METHODS AND COMPOSITIONS FOR ALTERING FUNCTION AND STRUCTURE OF CHROMATIN LOOPS AND/OR DOMAINS  
Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example...
US20180243385 METHODS FOR INDUCING SELECTIVE APOPTOSIS  
Provided herein are methods for cell therapy by modifying transfused cells to express an inducible caspase 9 protein, so that the cells may be selectively killed if the patient experiences...
10052310 Separase inhibitors and uses thereof  
In some embodiments, the present disclosure pertains to compositions with compounds that inhibit Separase activity. In additional embodiments, the present disclosure pertains to methods of...
US20180222931 STAT6 INHIBITORS  
The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some...
US20180218642 Altered Vision Via Streamed Optical Remapping  
Devices and methods for personalized real time optical remapping of streamed content are provided. The personalized optical remapping can correct for a wide variety of visual deficiencies or...
US20180201663 METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTORS AND ADAPTORS THEREOF  
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing pattern recognition receptor activity, and CD40 activity. Also provided are methods for...
10024856 Identification and characterization of a peptide affinity reagent for the detection of noroviruses in clinical samples  
Embodiments of the disclosure include methods and/or compositions for the detection of viral infection, including at least Norovirus infection. In particular embodiments, there are methods and/or...
10019912 Providing information to a user through somatosensory feedback  
A hearing device may provide hearing-to-touch sensory substitution as a therapeutic approach to deafness. Through use of signal processing on received signals, the hearing device may provide...
US20180187152 PEPMIXES TO GENERATE MULTIVIRAL CTLS WITH BROAD SPECIFICITY  
The present invention concerns methods of generating CTLs that are able to target at least one antigen from two or more viruses. The method includes exposing mixtures of peptides for different...
US20180170992 CAR T CELLS RECOGNIZING CANCER-SPECIFIC IL 13Ra2  
Provided are specific binding molecules, or fragments thereof, that bind to an epitope of IL13Rα2, a receptor polypeptide preferentially found on the surface of cancer cells rather than healthy...
US20180161297 BENEFITS OF SUPPLEMENTATION WITH N-ACETYLCYSTEINE AND GLYCINE TO IMPROVE GLUTATHIONE LEVELS  
The present invention concerns compositions and methods related to utilizing glycine and N-acetylcysteine for a variety of medical conditions related to reduced levels of glycine,...
9981010 Methods and compositions for bone formation  
A method and system to induce bone growth by locally delivering bone morphogenetic proteins (BMPs) to the target location for a prolonged period without invasive procedures are disclosed. The new...
9976122 Methods and compositions for generating an immune response by inducing CD40 and pattern recognition receptor adapters  
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40...
US20180127717 DENDRITIC CELL IMMUNOTHERAPY  
Methods of providing a targeted immune response in a subject comprising administration of a dendritic cell population are provided. In some aspects, dendritic cells are administered in conjunction...
9963677 Generation of CTL lines with specificity against multiple tumor antigens or multiple viruses  
The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In...
US20180117084 METHODS FOR ENHANCING AN IMMUNE RESPONSE WITH A CTLA-4 ANTAGONIST  
Methods are provided for enhancing an immune response comprising providing an immunogenic composition in conjunction with a CTLA-4 antagonist. Dendritic cell populations having reduced CTLA-4...
9956319 Compositions useful as antibiofilm or antimicrobial agents and methods using same  
The present invention includes compositions and methods useful for removing microorganisms and/or biofilm-embedded microorganisms from the surface of a medical device or subject's body. The...
US20180104337 CHIMERIC CD27 RECEPTORS FOR REDIRECTING T CELLS TO CD70-POSITIVE MALIGNANCIES  
The present invention concerns methods and compositions related to T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies. In aspects of the invention, T cells that...
US20180104308 CD5 CHIMERIC ANTIGEN RECEPTOR FOR ADOPTIVE T CELL THERAPY  
Embodiments of the disclosure include methods and compositions related to immunotherapy that targets CD5. In particular embodiments, immune cells engineered to comprise a chimeric antigen receptor...
9943608 Multi-arm biodegradable polymers for nucleic acid delivery  
In some embodiments, the present disclosure pertains to compositions for nucleic acid delivery into cells. In some embodiments, the composition comprises: (1) a cationic polymer unit comprising a...
US20180085399 UNIVERSAL IMMUNE CELLS FOR CANCER IMMUNOTHERAPY  
Embodiments of the disclosure encompass adoptive immunotherapy related to cells expressing multiple chimeric antigen receptors (CARs). In specific embodiments, T cells express a HER2-specific CAR,...
US20180079824 HER2/ErbB2 Chimeric Antigen Receptor  
Embodiments of the disclosure include immune cells expressing HER2-specific chimeric antigen receptors (CAR) and treatment of cancer therewith. In specific embodiments, sarcoma or glioblastoma are...
US20180071502 VAGINAL STENTS, VAGINAL DILATORS, AND METHODS OF FABRICATING THE SAME  
One aspect of the invention provides a vaginal stent system including: an inflatable vaginal stent and a removable handle. The inflatable vaginal stent include includes: an elastomeric exterior...
9913887 Ureaplasma vaccine and antibodies  
The present invention encompasses methods and compositions for Ureaplasma infection prevention and/or treatment. In specific cases, the invention concerns vaccines for Ureaplasma, including DNA...
US20180066252 p63 INACTIVATION FOR THE TREATMENT OF HEART FAILURE  
Embodiments of the disclosure include methods and compositions for in situ cardiac cell regeneration, including transdifferentiation of cardiac cells to cardiomyocytes. In particular embodiments,...
US20180044673 METHODS FOR MODULATING MECP2 EXPRESSION  
Disclosed herein are methods for decreasing MECP2 mRNA and protein expression. Such methods are useful to treat, prevent, or ameliorate MECP2 associated disorders and syndromes. Such MECP2...
US20180035962 PHANTOMS AND METHODS AND KITS USING THE SAME  
One aspect of the invention provides a phantom including a confined fluidic path defining a plurality of regions of monotonically decreasing, discrete cross-sectional dimensions with respect to an...
9886665 Event detection using roles and relationships of entities  
A method, system, and computer program product for event detection using roles and relationships of entities are provided in the illustrative embodiments. A training event and a set of entities...
US20180008730 MULTIFUNCTIONAL FLUORESCENT AND MRI-ACTIVE NANOSTRUCTURE  
A Magnetic Resonance Imaging (MRI) enhancement agent includes a plurality of particles, each particle including: a metal core; a dielectric shell disposed on the metal core comprising at least one...
US20180002371 BUFALIN PHOSPHATE PRODRUGS AND METHODS OF USE THEREOF  
Bufalin phosphate prodrugs are provided herein, as well as methods for their use as small molecule inhibitors of steroid receptor coactivator (SRC) family proteins. Methods for using bufalin...
US20170369884 MicroRNAs Sensitize Cancers to Therapy  
The present invention concerns methods and compositions regarding one or more microRNAs or variants thereof that are provided to an individual for a variety of medical treatments, including...
US20170362649 METHOD FOR IN SITU DETERMINATION OF NUCLEIC ACID PROXIMITY  
Disclosed is an in situ method for detecting spatial proximity relationships between nucleic acid sequences, such as DNA, in a cell. The method includes: providing a sample of one or more cells...
US20170362286 NOVEL POTASSIUM CHANNEL BLOCKERS AND USE THEREOF IN THE TREATMENT OF AUTOIMMUNE DISEASES  
Novel analogues of the sea anemone Stichodactyla helianthus toxin ShK, and their use as, for example, therapeutic agents for treating autoimmune diseases are disclosed. The analogues comprise a...
US20170360581 RESPONSIVE PROSTHESES  
One aspect of the invention provides a prosthetic foot including a heel member, a toe member, and an attachment member comprising a shear thickening material (STM). In one embodiment, the...
US20170335402 DOT1L INHIBITORS AND USES THEREOF  
The present disclosure relates to methods of treating AML, associated with DNMT3A mutations by administering one or more DOT1L inhibitors or related pharmaceutical compositions to subjects in need...
US20170335290 SURVIVIN SPECIFIC T-CELL RECEPTOR TARGETING TUMOR BUT NOT T CELLS  
Embodiments of the disclosure concern engineered T cell receptors that are specific for the survivin tumor antigen but do not have “on-target off tumor” toxicity. In particular embodiments,...
US20170333267 MOBILE CLINICS  
One aspect of the invention provides a mobile clinic including: an intermodal container defining at least a first opening and a second opening; a partition wall located within the intermodal...
US20170325934 MAGNETIC ASSISTED IN-SITU TUBULAR STENTGRAFT FENESTRATION  
A magnet assisted surgical device, system, and method employs magnetic sections, catheters, and guidewires to modify tubular stentgrafts in-situ. One example application provides a more reliable...
9810966 Random access stimulated emission depletion (STED) microscopy  
Optical scanning system, comprising an optical system for guiding a first and a second light beam, and deflector devices for deflecting first and second light beams in a directionally variable...
US20170316148 Method To Identify Genes Under Positive Selection  
A method and computer system for identifying genes associated with a phenotype includes obtaining data representing mutations in a cohort of subjects exhibiting a phenotype. An evolutionary action...
US20170312238 METHODS OF MODULATION OF BRANCHED CHAIN ACIDS AND USES THEREOF  
A method of modulating plasma levels of branched chain amino acids and branched chain alpha-keto acids is disclosed, wherein an ammonia scavenger compound or a salt thereof, for example...
US20170306327 HIPPO AND DYSTROPHIN COMPLEX SIGNALING IN CARDIOMYOCYTE RENEWAL  
Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for...
9789120 Male contraceptive compositions and methods of use  
The invention relates to compositions and methods for effecting male contraception.
US20170290830 SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF  
Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related...
US20170290510 FETAL PULSE OXIMETERS AND METHODS OF USING THE SAME  
One aspect of the invention provides a fetal pulse oximeter including: a shape-memory member adapted and configured to expand outward and define a loop when advanced out of a cannula; one or more...