Patents and Patent Applications from Baylor College of Medicine


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9789120 Male contraceptive compositions and methods of use  
The invention relates to compositions and methods for effecting male contraception.
US20170290830 SMALL MOLECULE REGULATORS OF STEROID RECEPTOR COACTIVATORS AND METHODS OF USE THEREOF  
Small molecule regulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing SRC-related diseases. The SRC-related...
US20170290510 FETAL PULSE OXIMETERS AND METHODS OF USING THE SAME  
One aspect of the invention provides a fetal pulse oximeter including: a shape-memory member adapted and configured to expand outward and define a loop when advanced out of a cannula; one or more...
US20170281683 GLYPICAN-3 SPECIFIC CHIMERIC ANTIGEN RECEPTORS FOR ADOPTIVE IMMUNOTHERAPY  
Embodiments of the disclosure include methods and compositions related to immunotherapy that targets glypican-3. In particular embodiments, immune cells engineered to comprise a chimeric antigen...
US20170275644 PLANTS WITH ENHANCED TOLERANCE TO MULTIPLE ABIOTIC STRESSES  
The present disclosure describes genetically-modified plants having enhanced tolerance to multiple abiotic stressors, such as extreme temperatures (heat or cold) and/or drought. Abiotic stress...
9765099 STAT6 inhibitors  
The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some...
9758785 miR-520 microRNAs sensitize cancers to platinum-based therapy  
The present invention concerns methods and compositions regarding one or more microRNAs or variants thereof that are provided to an individual for a variety of medical treatments, including...
US20170252334 ATAXIA THERAPEUTIC COMPOSITIONS AND METHODS  
A method for treating a subject having, or at risk of having, ataxia, generally includes administering to the subject an amount of a composition comprising a cholecystokinin receptor (Cck1R)...
US20170247439 METHODS FOR TREATING OSTEOGENESIS IMPERFECTA  
The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a...
US20170246278 BIPARTITE AND TRIPARTITE SIGNALING IMMUNE CELLS  
Embodiments of the disclosure include compositions and methods effective for immunotherapy, such as for cancer. The embodiments include cells that recognize a combination of two signals or three...
9737499 Methods of modulation of branched chain acids and uses thereof  
A method of modulating plasma levels of branched chain amino acids and branched chain alpha-keto acids is disclosed, wherein an ammonia scavenger compound or a salt thereof, for example...
9732345 Hippo and dystrophin complex signaling in cardiomyocyte renewal  
The present invention is directed to methods and compositions that provide therapy for at least one medical condition that directly or indirectly affects cardiac muscle cells (also known as...
US20170219599 PROBES FOR QUANTITATIVE IMAGING OF THIOLS IN VARIOUS ENVIRONMENTS  
Embodiments of the present disclosure pertain to methods of detecting a thiol in an environment by exposing the environment to a probe molecule that contains a marker and a thiol responsive group....
9720902 Intention detection in domain-specific information  
A new information in a language and relating to a subject matter domain is parsed into a constituent set of complete grammatical constructs. In a subset of the complete grammatical constructs, a...
US20170209579 NON-INVASIVE RADIOFREQUENCY FIELD TREATMENT FOR CANCER THERAPY  
Embodiments of the disclosure concern methods and compositions for treating a subject with cancer, including overcoming resistance to a cancer drug using non-invasive radiotherapy frequency in...
9708377 Scorpion toxin analogue and method for treating autoimmune diseases  
A novel peptide analogue of the Heterometrus spinnifer toxin HsTX1 is disclosed along with its application as, for example, a therapeutic agent for treating an autoimmune disease such as multiple...
US20170189175 ARTIFICIAL, FLEXIBLE VALVES AND METHODS OF FABRICATING AND SERIALLY EXPANDING THE SAME  
One aspect of the invention provides an artificial, flexible valve including: a stent defining a wall and a plurality of leaflets extending from the wall of the stent. The plurality of leaflets...
US20170188553 EPIGENETIC ENGINEERING TO STUDY THE ROLE OF ABERRANT DNA METHYLATION IN DISEASE  
Embodiments of the disclosure concern compositions and methods for genetic engineering related to hypermethylation of sequences. In particular embodiments, there are methods and compositions to...
US20170183721 METHODS OF LINEARLY AMPLIFYING WHOLE GENOME OF A SINGLE CELL  
Embodiments of the disclosure encompass methods of amplifying nucleic acid from one or more cells using MALBAC (multiple annealing and looping-based amplification cycles) primers. In particular...
US20170182140 INDUCED ACTIVATION IN DENDRITIC CELLS  
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
US20170178539 PROVIDING INFORMATION TO A USER THROUGH SOMATOSENSORY FEEDBACK  
A hearing device may provide hearing-to-touch sensory substitution as a therapeutic approach to deafness. Through use of signal processing on received signals, the hearing device may provide...
9683237 Multiple targeted RNAI for the treatment of cancers  
The present invention includes compositions and methods for making and using a RNAi capable of reducing expression of two or more genes, comprising: a first RNAi molecule that reduces the...
9644205 Synthetic promoter for modulating gene expression  
The present invention provides nucleic acid constructs, expression vectors, transgenic cell and methods of making and using the same, wherein the nucleic acid construct includes a synthetic...
9642906 Generation of HPV-specific T-cells  
Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern...
9637470 Treatment for substance use disorders and stress disorders  
Treatments are described for stress disorders and substance use disorders, for example, substance use disorders associated with use of alcohol, cocaine, amphetamines, and the like.
9636323 Method of treating cancer that overexpresses TopBP1  
The present invention provides a method of treating cancer that overexpresses TopBP1 by administering to a patient suffering from the cancer with an effective amount of a small molecule inhibitor...
9626845 Providing information to a user through somatosensory feedback  
A hearing device may provide hearing-to-touch sensory substitution as a therapeutic approach to deafness. Through use of signal processing on received signals, the hearing device may provide...
9622988 Small molecule xanthine oxidase inhibitors and methods of use  
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
9617539 Modulation of UBE3A-ATS expression  
Certain embodiments are directed to methods and compounds for inhibiting UBE3A-ATS, the endogenous antisense transcript of ubiquitin protein ligase E3A (UBE3A). Such methods and compounds are...
9610257 Small molecule xanthine oxidase inhibitors and methods of use  
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
US20170081666 MICRORNA-198 AS A TUMOR SUPPRESSOR IN OVARIAN CANCER  
A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central...
US20170080166 Device and System for Insertion of Penetrating Member  
A system, device and method for insertion of a penetrating member into tissue is disclosed, which may be handheld and automated. A detector obtains data regarding subdermal locations of tissue...
9598486 Methods for treating osteogenesis imperfecta  
The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a...
US20170067903 METABOLIC BIOMARKER FOR DIAGNOSIS AND TREATMENT OF METASTATIC PROSTATE CANCER  
Embodiments of the disclosure include methods and compositions for treatment of prostate cancer, including metastatic prostate cancer or prostate cancer at risk for developing into metastatic...
9585848 Small molecule xanthine oxidase inhibitors and methods of use  
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
9585847 Small molecule xanthine oxidase inhibitors and methods of use  
Small molecule xanthine oxidase inhibitors are provided, as well as methods for their use in treating gout or hyperuricemia.
US20170056647 SYSTEMS AND METHODS FOR ATTACHING FLEXIBLE CONDUCTIVE FILAMENTS, NETWORKS, OR PATCHES TO TISSUE VIA CATHETER DELIVERY  
Systems and methods for deploying and securing conductive materials to a region of tissue may utilize a catheter. The catheter may provide a tip with one or more detachable sections or may provide...
9580379 Xanthine oxidase inhibitors and methods of use  
Small molecule xanthine oxidase inhibitors are provided, as well as compositions, methods for their use for treating disorders, mediated at least in part, by xanthine oxidase.
9572835 Induced activation in dendritic cells  
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions...
9572834 Use of carbon nanomaterials with antioxidant properties to treat oxidative stress  
In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the...
US20170028052 GENERATION OF HPV-SPECIFIC T-CELLS  
Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern...
US20170027988 IMMUNOTHERAPY OF CANCER USING GENETICALLY ENGINEERED GD2-SPECIFIC T CELLS  
The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is...
9546365 MicroRNA-198 as a tumor suppressor in ovarian cancer  
A novel network of tumorigenic prognostic factors is identified that plays a critical role in advanced pancreatic cancer (PC) pathogenesis. This interactome is interconnected through a central...
US20170002321 METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS  
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40...
US20160378941 Systems and Methods of Improving Communications Amongst Healthcare Professionals  
Systems and methods are disclosed for optimizing discrete medical communication and patient care team coordination leveraging diagnosis and patient specific data in the Electronic Medical Records...
US20160376375 CSGP4 - Specific Chimeric Antigen Receptor for Cancer  
Embodiments of the disclosure include methods and compositions related to chimeric antigen receptors (CAR) that target chondroitin sulfate proteoglycan-4 (CSPG4). T cells transduced with a...
US20160376321 A NOVEL SARS IMMUNOGENIC COMPOSITION  
Embodiments of the disclosure concern immunogenic compositions and methods for treating or preventing Severe acute respiratory syndrome (SARS). The compositions and methods concern a portion of...
US20160362658 GENERATION OF CTL LINES WITH SPECIFICITY AGAINST MULTIPLE TUMOR ANTIGENS OR MULTIPLE VIRUSES  
The present invention encompasses methods and compositions for the generation and use of cytotoxic T lymphocytes that target multiple viruses or that are specific for multiple tumor antigens. In...
US20160340743 RECURRENT FUSION GENES IDENTIFIED IN HIGH -GRADE SEROUS OVARIAN CARCINOMA  
Embodiments of the disclosure include methods and compositions associated with CDKN2D-WDFY2 chimeric RNA, the fusion gene that produces the chimeric RNA, and polypeptides produced from the...
9493740 Immunotherapy of cancer using genetically engineered GD2-specific T cells  
The present invention concerns immunotherapy for cancers having cells that comprise the ganglioside GD2 antigen. In specific embodiment, T cells having a chimeric receptor that targets GD2 is...