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US20120021405 |
Single Chain Antibody for the Detection of Noroviruses
The present invention concerns compositions and methods for detecting Norovirus or Norovirus particles. In particular, the present invention encompasses antibodies for detecting Norovirus or...
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8089628 |
Pulsed-multiline excitation for color-blind fluorescence detection
The present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput...
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8084753 |
Method and system for non-contact fluorescence optical tomography with patterned illumination
A method and system for non-contact fluorescent optical tomography using patterned illumination is disclosed. The method comprises illuminating a surface of a medium with light from at least one...
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8062691 |
Method for treating medical devices using glycerol and an antimicrobial agent
A non-metallic medical device treated with a antimicrobial agents is provided. Different combinations of antimicrobial agents can be used for different types of non-metallic medical devices...
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8057415 |
Trauma cervical stability device and methods of using same for diagnostic purposes
Trauma cervical stability devices for use by ambulatory personnel arriving at the scene of an injured patient are disclosed. The trauma cervical stability devices comprise a cap element, releasable...
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US20110263014 |
Cleavage of Nanog by Caspases Mediates the Differentiation of Embryonic Stem Cells
The present invention is based on the discovery that a caspase specifically cleaves the transcription factor, Nanog, leading to the initiation of cellular differentiation of embryonic stem (ES)...
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US20110212076 |
Viral Therapeutic
The invention provides a method of inhibiting viral infection of a mammalian cell, said method comprising reducing or inhibiting ps20 polypeptide expressed by said cell. Suitably ps20 is inhibited...
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US20110201109 |
Ronin is Essential for Perpetuity of Mouse ES Cells, and Acts Independently of Canonical Pathways
The present invention, therefore, encompasses compositions and methods comprising Ronin, a Ronin activator, and methods of their use for maintaining the perpetuity of an ES cell phenotype.
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US20110197628 |
CRYOAGGREGATE FILTRATION FOR THE TREATMENT OF CARDIOMYOPATHY AND OTHER AUTOIMMUNE DISEASES
Various embodiments of the present invention disclose processes and systems for the off-line in-vitro purification of plasma harvested from a patient. In an embodiment of a process, in a first step...
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US20110189263 |
PEPTIDES THAT TARGET DORSAL ROOT GANGLION NEURONS
The present invention concerns methods and compositions that employ peptides that target dorsal root ganglion (DRG) neurons. In particular, the peptides are used to target therapeutic agents, such...
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US20110178555 |
BONE COMPRESSION DEVICE
The invention relates to bone compression devices and bone compression systems, and in particular, to bone compression devices and systems for use in connection with vertebrae. The bone compression...
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7972801 |
Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin B peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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US20110160284 |
SUPERCOILED MINICIRCLE DNA FOR GENE THERAPY APPLICATIONS
The present invention relates to nucleic acid molecule compositions comprising minivectors encoding a nucleic acid sequence and methods of gene therapy using minivectors encoding a nucleic acid...
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US20110158915 |
NANOSHELLS WITH TARGETED ENHANCEMENT OF MAGNETIC AND OPTICAL IMAGING AND PHOTOTHERMAL THERAPEUTIC RESPONSE
A particle and a method of manufacturing a particle that includes a complex, a paramagnetic entity, and a silica layer that encapsulates the paramagnetic entity and the complex. The dielectric...
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7968304 |
Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin B peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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7931679 |
Bone compression device
The invention relates to bone compression devices and bone compression systems, and in particular, to bone compression devices and systems for use in connection with vertebrae. The bone compression...
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7879793 |
Treatment of medical condition with A2 domain of von willebrand factor
The present invention is directed to methods for the prevention, treatment and/or diagnosis of a medical condition, such as sepsis, systemic inflammatory reaction syndrome, and/or thrombosis, for...
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US20110020786 |
PEPTIDE DENDRIMERS: AFFINITY REAGENTS FOR BINDING NOROVIRUSES
Noroviruses are recognized as the most common cause of outbreaks of acute gastroenteritis in humans. Therefore, the present invention relates to peptides or dendrimers that bind Noroviruses and the...
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7875260 |
Imaging agents for functional imaging of lymphatic structures
Novel imaging agents targeted to a lymph vascular cell receptor and a hyaluranon cell receptor are disclosed. The disclosed imaging agents incorporate biological molecules such as hyaluronic acid...
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7868159 |
Modulation of negative immune regulators and applications for immunotherapy
The invention includes compositions and methods for enhancing immunopotency of an immune cell by way of inhibiting a negative immune regulator in the cell. The present invention provides vaccines...
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7868158 |
Modulation of cytokine signaling regulators and applications for immunotherapy
The present invention relates to regulation of antigen presentation by cytokine signaling regulators in antigen presenting cells, such as dendritic cells. The invention provides methods of...
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US20100331281 |
PHOSPHOLIPID COMPOSITIONS AND USES THEREOF
We have discovered that phospholipids diundecanoyl (C11:0-C11:0) and dilauroyl (C12:0-C12:0) phosphatidylcholine (PC) act as agonists of the LRH-1 receptor. We have also shown that administration...
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7855268 |
Tolerogizing compositions comprising botulinum toxin type B peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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7848888 |
Method for identification of biologically active agents
The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of...
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7847146 |
Model for neurodegenerative disorders
The present invention discloses a double transgenic fly that expresses both Tau protein and the human Aβ42 peptide of human amyloid-β precursor protein (APP). The double transgenic flies of the p...
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US20100291123 |
T Cell Receptor CDR3 Sequences and Methods for Detection
The present invention relates generally to the field of treating autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis (RA) and others. Methods of treating and monitoring an...
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7829333 |
Modulation of hedgehog-mediated signaling pathway
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that...
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7824685 |
RTVP based compositions and methods for the treatment of prostate cancer
This invention relates to a gene encoding RTVP that has been shown to be up-regulated by p53 using differential display-PCR and subsequently by co-transfection studies. RTVP-1 mRNA is abundant in...
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US20100273862 |
Phosphatases which activate map kinase pathways
The present invention provides novel JNK activating phosphatase polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods...
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US20100266623 |
SYNTHETIC, SELF ADJUVANTING VACCINES
The present invention relates generally to the field of immunotherapy, and more particularly to immunomedicaments in the form of lipopeptides which induce an antibody response to drugs of...
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7811820 |
Smooth muscle cell differentiation with CRP, SRF and GATA factors
The present invention is directed to generating a smooth muscle cell from another cell, such as a fibroblast, by delivering to the cell serum response factor, a CRP, and a GATA. In specific...
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US20100241241 |
REMOTE ACTUATED VALVE IMPLANT
Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to...
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US20100239548 |
Isolation and Identification of T Cells
The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as...
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7790183 |
Combination of antimicrobial agents and bacterial interference to coat medical devices
This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of said medical device, an antimicrobial coating layer and a...
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US20100216119 |
Diagnostic Methods for HIV Infection
The invention relates to a method of aiding the diagnosis of a human immunodeficiency virus infection in a subject, said method comprising (i) providing a sample from the subject (ii) determining...
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US20100203067 |
METHODS AND COMPOSITIONS FOR GENERATING AN IMMUNE RESPONSE BY INDUCING CD40 AND PATTERN RECOGNITION RECEPTOR ADAPTERS
Provided are methods for activating an antigen-presenting cell and eliciting an immune response by inducing an inducible pattern recognition receptor adapter, or adapter fragment, and CD40...
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US20100197610 |
FRUCTOSE 1, 6 BISPHOSPHATE - A NOVEL ANTICONVULSANT DRUG
The present invention concerns methods and compositions for preventing one or more epileptic seizures in an individual by delivering fructose-1,6-bisphosphate to the individual. In certain cases,...
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US20100183546 |
Method for Increasing CD8+ Cytotoxic T Cell Responses and for Treating Multiple Sclerosis
The present invention relates generally to the field of immunology and development of autologous vaccines. More specifically, the present invention is concerned with a method of treating autoimmune...
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7744893 |
T cell receptor CDR3 sequences associated with multiple sclerosis and compositions comprising same
The present invention relates generally to the field of treating and monitoring multiple sclerosis by utilizing T-cell receptors peptides. In particular, nucleic acids and peptide sequences of...
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US20100143255 |
FIG4 GENE MUTATIONS IN NEURODEGENERATION
The present invention relates to neuropathy, in particular to mutations in the FI G4 gene. The present invention also provides assays for the detection of variant FIG4 alleles, and assays for...
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7723475 |
RTVP-GliPR-like compositions and methods for the detection, treatment and prevention of prostate cancer
The invention is directed to purified and isolated novel RGL2 polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides,...
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US20100112610 |
Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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US20100112609 |
Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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US20100112082 |
Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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US20100111962 |
Determining and Reducing Immunoresistance to a Botulinum Toxin Therapy Using Botulinum Toxin B Peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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7706584 |
Random access high-speed confocal microscope
Disclosed herein is a confocal imaging system for imaging a specimen. The system comprises a light source, a light deflector capable of positioning a beam of light produced by the light source at...
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7695713 |
Isolation and identification of T cells
The present invention relates to improved autologous T cell vaccines and improved methods for their production. The invention is also directed to methods for treating autoimmune diseases such as...
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7691587 |
Determining and reducing immunoresistance to a botulinum toxin therapy using botulinum toxin B peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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7686758 |
Cannula tip for a cardiac assist device
The present invention provides an inflow cannula tip that is shaped to prevent suction with the ventricular wall and adapted to prevent platelet adhesion. In particular, the inlet portion of the...
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7670788 |
Determining and reducing immunoresistance to a Botulinum toxin therapy using Botulinum toxin B peptides
The present invention provides BoNT/B peptides, BoNT/B peptide compositions, tolerogizing compositions, immune response inducing compositions, as well as methods of determining immunoresistance to...
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