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5780223 |
Molecular diagnosis of autosomal dominant Charcot-Marie-Tooth disease
A description of an isolated CMTIA-REP sequence and DNA probes to the sequence. Methods for the use of such sequences and probes to detect peripheral neuropathies. A method for detecting...
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5776692 |
Mycobacterial genus-specific DNA probe and its expressed product
Recombinant clone pMptb #48 expressing a 36k M. paratuberculosis antigen is provided that provides a more sensitive and discriminating test than those in which crude antigens have been used. A...
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5776689 |
Protein recruitment system
The present invention provides a protein recruitment system, in which a protein-protein interaction is detected by the recruitment of an effector protein to a specific cell compartment, where the...
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5770580 |
Somatic gene therapy to cells associated with fluid spaces
This invention relates to somatic gene therapy to cells associated with fluid spaces, such as follicles of the thyroid, the synovium of the joint, the vitreous of the eye and the inner or middle...
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5766939 |
Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA...
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5759785 |
Method of identifying hormone antagonists and agonists
The present invention provides a novel method of determining the antagonist and agonist activity of a compound for steroid hormone receptors. The present invention also provides a method of...
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5756264 |
Expression vector systems and method of use
This invention relates to gene therapy by using vectors which encode stable MRNA and methods of using such vectors. In particular, this invention relates to vectors which establish controlled...
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5756145 |
Durable, Resilient and effective antimicrobial coating for medical devices and method of coating therefor
A medical implant, such as an orthopedic implant, having a first antimicrobial coating layer and a second protective layer, and a method for coating such an implant is provided. The medical implant...
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5750367 |
Human and mouse very low density lipoprotein receptors and methods for use of such receptors
Methods of treating diseases or conditions, characterized by elevated serum lipoprotein levels, by providing elevated levels of a VLDL receptor in an animal, e.g., a human are set forth. Such...
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5728529 |
Alternative dye-labeled ribonucleotides, deoxyribonucleotides, and dideoxyribonucleotides for automated DNA analysis
Methods for the use of a class of dyes for improved DNA sequencing by the chain termination method of DNA sequencing, and internal labelling of polynucleotides by enzymatic incorporation of...
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5719060 |
Method and apparatus for desorption and ionization of analytes
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass...
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5713730 |
Ceramic pivot bearing arrangement for a sealless blood pump
A centrifugal blood pump, used for heart-lung machines or the like, having at least one impeller, a casing having an inlet and an outlet, the casing formed to have a space for rotatably housing the...
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5691136 |
Fingerprinting bacterial strains using repetitive DNA sequence amplification
Oligonucleotide primers and methods for identifying strains of bacteria by genomic fingerprinting are described. The methods are applicable to a variety of samples. The testing procedure includes...
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5688516 |
Non-glycopeptide antimicrobial agents in combination with an anticoagulant, an antithrombotic or a chelating agent, and their uses in, for example, the preparation of medical devices
Compositions and methods of employing compositions in flushing and coating medical devices are disclosed. The compositions include selected combinations of a chelating agent, anticoagulant, or...
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5683885 |
Methods for diagnosing an increased risk for breast or ovarian cancer
The present invention relates to method for diagnosing an increased risk for breast or ovarian cancer by assaying for the presence of a mutant human progesterone receptor protein which contains a...
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5676161 |
Surgical procedures for mastopexy and reduction mammaplasty
A mastopexy or mammaplasty procedure to reshape and/or reduce the size of sagging breasts includes the steps of making a generally anchor-shaped incision having a bottom line along the inframammary...
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5664577 |
Method and apparatus for distortion product emission testing of hearing
Apparatus and method for the recording of distortion product emission (DPE) levels in human beings. At least one microphone and a sound-delivery system is inserted in the external ear canal. Two...
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5656743 |
Oligonucleotide modulation of cell growth
Oligonucleotides capable of inhibiting the production of proliferation-associated proteins are provided. Oligonucleotides designed to be hybridizable with nucleic acids encoding nucleolar proteins...
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5653939 |
Optical and electrical methods and apparatus for molecule detection
A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is...
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5645995 |
Methods for diagnosing an increased risk for breast or ovarian cancer
The present invention relates to methods for diagnosing an increased risk for breast or ovarian cancer by assaying for genetic markers in the human progesterone receptor gene.
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5631236 |
Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
The present invention provides a novel method of treating localized solid tumors and papilloma in an individual. The method comprises introducing a recombinant adenoviral vector containing the...
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5627039 |
Mortalin and methods for determining complementation group assignment of cancer cells
The intracellular distribution of mortalin is used to determine the complementation group of tumor cells. Also disclosed are the gene sequences that encode mortalin and the amino acid sequence of...
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5624704 |
Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent
A non-metallic antimicrobial impregnated medical implant, such as a catheter, and a method for impregnating a non-metallic medical implant with an antimicrobial agent is provided. The method for...
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5616122 |
Methods and compositions for preventing secondary cataracts
Novel methods and compositions are provided for preventing secondary cataracts. A cytotoxic agent is employed which is introduced into the anterior chamber of the eye to inhibit proliferation of...
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5614403 |
In vitro replication system capable of rescuing cloned and manipulated rotavirus genes
A method for template-dependent in vitro replication and transcapsidation of double stranded RNA from Reoviridae mRNA templates is described. This method provides an efficient means for isolating...
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5614396 |
Methods for the genetic modification of endogenous genes in animal cells by homologous recombination
A method for producing animal cells, chimeric or transgenic non-human animals which contain a desired gene sequence inserted into a predetermined gene sequence. The method permits the production of...
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5614386 |
Alternative dye-labeled primers for automated DNA sequencing
Methods for the use of a class of dyes for improved DNA sequencing are provided. A new class of dyes, BODIPY® fluorophore, has been described recently. The parent heterocyclic molecule of the ...
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5602307 |
Non-human animal having predefined allele of a cellular adhesion gene
A transgenic mouse which contains a predefined, specific and desired alteration in at least one of its two chromosomal alleles of a cellular adhesion gene, such that at least one of these alleles...
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5601816 |
Infectious bovine rhinotracheitis virus insertion mutants, vaccines containing same, and methods for the production of same
The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines...
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5601418 |
Blood pump
A centrifugal blood pump for heart-lung machines or the like. An impeller is provided with pump vanes and a magnet. The impeller is rotatably accommodated in a casing having an inlet and an outlet....
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5599920 |
Peripheral myelin protein coding sequence and method
The disclosed invention includes a a peripheral myelin protein, PMP-22, which is present predominantly in the peripheral nervous system and purified nucleic acids which encode the protein. Also...
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5582989 |
Multiplex genomic DNA amplification for deletion detection
The present invention relates to a method for detecting multiple DNA sequences simultaneously. The method involves amplification of multiple sequences simultaneously by annealing a plurality of...
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5578496 |
Detection of autoantibodies associated with the disease myasthenia gravis
This invention is directed towards peptidic compositions, methods, and diagnostic kits for the accurate and sensitive detection of human acetylcholine receptor (AChR) autoantibodies associated with...
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5578458 |
Mutation detection by competitive oligonucleotide priming
The present invention relates to a process for the rapid and simple detection of mutations in DNA and differences between DNA sequences. This competitive oligonucleotide priming system can be used...
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5575630 |
Blood pump having magnetic attraction
A blood pump used for heart-lung machines comprising an impeller, a casing having a suction inlet and a delivery outlet and rotatably encasing the impeller, a magnetic driver disposed outside the...
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5571896 |
Production of recombinant human lactoferrin
The present invention provides novel plasmids, transfected eucaryotic cells and methods of producing these plasmids and transfected eucaryotic cells. The novel plasmid contains the cDNA for human...
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5571697 |
Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
The subject invention provides for the production of lactoferrins and lactoferrin polypeptide fragments using the host cells Aspergillus in combination with novel plasmid constructs. More...
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5571691 |
Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
The verified cDNA sequences for human, bovine and porcine lactoferrin protein have been used to prepare recombinant lactoferrin for therapeutic and nutritional applications. Regions of the cDNA...
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5569824 |
Transgenic mice containing a disrupted p53 gene
A desired non-human animal or an animal cell or human cell which contains a predefined, specific and desired alteration in at least one of its two p53 chromosomal alleles, such that at least one of...
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5559014 |
Methods and reagents to detect and characterize Norwalk and related viruses
Double-stranded cDNA was synthesized from nucleic acid extracted from Norwalk virus purified from stool specimens of volunteers. One clone was isolated from a cDNA library constructed in a pUC-13...
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5552282 |
Diagnosis of myotonic muscular dystrophy
The present invention includes a DNA clone from the myotonic muscular dystrophy gene, a cosmid probe to the myotonic dystrophy site, as well as methods of detecting myotonic muscular dystrophy...
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5545563 |
Human C/EBP gene and vectors for its expression
A gene sequence that encodes the human CCAAT/enhancer binding protein ("C/EBP"), and recombinant vectors that are capable of mediating the expression of the C/EBP gene are described. The gene...
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5526819 |
Method and apparatus for distortion product emission testing of heating
Apparatus and method are disclosed for the recording of distortion product emission (DPE) levels in human beings. At least one microphone and a sound-delivery system is inserted in the external ear...
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5523217 |
Fingerprinting bacterial strains using repetitive DNA sequence amplification
Oligonucleotide primers and methods for identifying strains of bacteria by genomic fingerprinting are described. The methods are applicable to a variety of samples. The testing procedure includes...
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5523040 |
Method and apparatus for making a custom support
A method and apparatus for making a custom resilient foam support for a human body from a foam block having first and second opposite sides. The method includes placing the first side of the foam...
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5512648 |
Polyamide resin-protide conjugate, preparation and uses
A large pore polyamide resin is useful for large peptide and protein (protide) synthesis. A method of preparing the same comprises mixing a dimethylacrylamide monomer with an unsaturated or...
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5496800 |
Growth inhibitory factor from urogenital sinus
A process is provided for purifying Urogenital Sinus Derived Growth Inhibitory Factor (UGIF) from embryonic tissue which comprises chromatographing medium from cultures or culture-derived spheroids...
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5484704 |
Monoclonal antibody for diagnostic use in ovarian cancer
A method for the diagnosis and treatment of ovarian cancer. Tissue and body fluid samples are assayed for an antigen which specifically binds an anti-OSE antibody to diagnose ovarian cancer.
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5424400 |
Senescent cell derived inhibitors of DNA synthesis
An expression vector cDNA library derived from senescent cells has been used to isolate cDNA clones that encode inhibitors of DNA synthesis. Such inhibitors play a role in cellular senescence and...
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5424192 |
Markers for invasive prostatic neoplasia
This invention is directed to the identification, isolation and use of nonprostate derived markers, such as markers derived from the seminal vesicles, and antibodies which recognize these markers...
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