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6496612 |
Electronically latching micro-magnetic switches and method of operating same
A switch with an open state and a closed state suitably includes a cantilever having first and second states corresponding to the open and closed states of the switch, respectively. The switch may...
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6488831 |
Chemical surface for control of electroosmosis by an applied external voltage field
The present invention is directed to a method for controlling electroosmotic flow by treating a surface with an organosilane having a single leaving group and optionally a ceramic oxide. This...
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6469603 |
Electronically switching latching micro-magnetic relay and method of operating same
According to various embodiments of the invention, a relay is suitably formed to exhibit an open state and a closed state. The relay is operated by providing a cantilever sensitive to magnetic...
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6469602 |
Electronically switching latching micro-magnetic relay and method of operating same
According to various embodiments of the invention, a relay is suitably formed to exhibit an open state and a closed state. The relay is operated by providing a cantilever sensitive to magnetic...
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6448556 |
Atomic focusers in electron microscopy
In electron microscopy, resolution is improved by using an atom or atom-array focuser, with the atom or atom array serving as an electrostatic lens at a focal plane of an electron beam probe having...
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6372178 |
Method for freeform fabrication of a three-dimensional object
An improved apparatus and method for forming a three-dimensional object by planar deposition of forming materials includes containers for holding molten forming materials, mechanical piston or...
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6316266 |
Sample presentation apparatus for mass spectrometry
A sample presentation device, with a surface-bound complex including at least one molecule which chemically modifies a biomolecule, is prepared and exposed to a biomolecule. The molecular weights...
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6309711 |
Method for manufacturing a three-dimensional object
Improved assembly and methods for manufacturing a three-dimensional object are described. The assembly includes a crucible for holding molten metal, an orifice disposed in the bottom of the...
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6306675 |
Method for forming a low-defect epitaxial layer in the fabrication of semiconductor devices
In semiconductor devices such as laser diodes (LD) and light emitting diodes (LED) based on gallium nitride thin films, low defect density is desired in the gallium nitride film. In the fabrication...
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6304784 |
Flexible probing device and methods for manufacturing the same
An improved probing device includes: an elongated, substantially cylindrical flexible fiber having a non-conducting outer surface; one or more circuits disposed on the outer surface of the fiber...
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6251340 |
Adaptable filament deposition system and method for freeform fabrication of three-dimensional objects
An improved system for forming a three-dimensional object by filament deposition of forming materials includes a crucible for holding a reservoir of the filament forming material, an orifice...
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6216765 |
Apparatus and method for manufacturing a three-dimensional object
Improved assembly and methods for manufacturing a three-dimensional object are described. The assembly includes a crucible for holding molten metal, an orifice disposed in the bottom of the...
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6149072 |
Droplet selection systems and methods for freeform fabrication of three-dimensional objects
An improved system for forming a three-dimensional object by selective deposition of a forming material includes a crucible for holding a reservoir of the forming material, an orifice disposed in...
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6113696 |
Adaptable filament deposition system and method for freeform fabrication of three-dimensional objects
An improved system for forming a three-dimensional object by filament deposition of forming materials includes a crucible for holding a reservoir of the filament forming material, an orifice...
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6093541 |
Mass spectrometer having a derivatized sample presentation apparatus
A mass spectrometer having a derivatized sample presentation apparatus is provided. The sample presentation apparatus has a complex bound to the surface of the sample presentation apparatus. This...
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6060505 |
Method of treating cancer using C-26 modified bryostatin
Disclosed are modified bryostatins and their use as anticancer drugs.
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6030199 |
Apparatus for freeform fabrication of a three-dimensional object
An improved apparatus and method for forming a three-dimensional object by planar deposition of forming materials includes containers for holding molten forming materials, mechanical piston or...
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6004777 |
Vectors having enhanced expression, and methods of making and uses thereof
Disclosed and claimed are vectors having enhanced expression and methods for making and using them. Enhancement of expression is from substantially co-temporal expression of at least one first...
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6004770 |
Sample presentation apparatus for mass spectrometry
A sample presentation device, with a surface-bound complex including at least one molecule which chemically modifies a biomolecule, is prepared and exposed to a biomolecule. The molecular weights...
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5939020 |
Chemical switch for detection of chemical components
A chemical switch device comprising a film which irreversibly reacts upon exposure to specific chemical components in the environment under the conditions of measurement. The reactions can lead to...
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5891395 |
Chemical switch for detection of chemical components
A chemical switch device comprising a film which irreversibly reacts upon exposure to specific chemical components in the environment under the conditions of measurement. The reactions can lead to...
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5801222 |
Isolation and structure of the human cancer cell growth inhibitory cyclic octapeptides phakellistatin 10 and 11
Two new compounds which may be useful in the treatment of one or more neoplastic diseases through chemotherapy have been isolated from the Western Pacific Ocean marine sponge Phakellia sp. The...
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5665860 |
Human cancer inhibitory peptide amides
This application discloses seven newly synthesized pentapeptide amides and our tetrapeptide amides. The synthesis utilized both naturally occurring and modified amino acids; the modified amino...
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5663149 |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
The synthesis and elucidation of nineteen heterocyclic or halophenyl amide erivatives of dolastatin 10 are disclosed. These compounds and the methods of producing those compounds offer demonstrated...
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5646246 |
Isolation and structural elucidation of the human cancer cell growth inhibitory cyclic peptides phakellistatin 4, 5, 6, 7, 8 and 9
The cytostatic, cyclic peptides; phakellistatin 4, phakellistatin 5, phakellistatin 6, phakellistatin 7, phakellistatin 8 and phakellistatin 9 were isolated from the Western Pacific Ocean sponge...
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5639881 |
Synthesis and elucidation of pyrimido (4,5-Q) quinazoline derivatives
Pyrimido[4,5-g]quinazoline quinone derivatives were synthesized as anthranone-like reductive alkylating agents. Like many naturally-occurring antibiotics, these quinone derivatives are designed to...
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5635483 |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
New tetrapeptides bearing modified phenethyl amides are elucidated and syesized and found to exhibit tumor inhibiting effects when measured against the NCI screen for six major types of human...
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5633433 |
Rubber particle protein gene from guayule
Guayule rubber particles, contain several characteristic proteins. The most abundant of these proteins, the rubber particle protein (RPP) has been shown to be a non-monooxygenase, cytochrome P450,...
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5602330 |
Non-contact force microscope having a coaxial cantilever-tip configuration
The present invention comprises a highly sensitive non-contact force microscope having a coaxial cantilever-tip configuration and a method of forming such configuration. The non-contact microscope...
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5599902 |
Cancer inhibitory peptides
The sea hare Dolabella auricularia has yielded many structurally distinct ptides which possess antineoplastic activity. Presently the compound denominated "dolastatin 10" represents the most...
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5583224 |
Isolation and elucidation of cephalostatin 7, 8 and 9
Substantially pure compositions of matter selected from the group of cephalostatin 7, cephalostatin 8, and cephalostatin 9 having anti-neoplastic activity are disclosed.
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5569786 |
Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins"
New antineoplastic substances have been isolated, structurally elucidated and synthesized having a general structural formula of: ##STR1## wherein: R1 is OH or OCH3 ; R2 is H or OCH3 ; or R1 R2 is...
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5561122 |
Combretastatin A-4 prodrug
Disclosed herein are Combretastatin A-4 Prodrugs, having the general strure set forth below, which are useful in the treatment of one or more neoplastic diseases by means of chemotherapy. ##STR1##
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5554725 |
Synthesis of dolastatin 15
The present invention relates to the synthesis of natural (-)- dolastatin and the elucidation of the absolute configuration of this important sea hare constituent. A segment synthetic strategy was...
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5530097 |
Human cancer inhibitory peptide amides
This application discloses seven newly synthesized pentapeptide amides and our tetrapeptide amides. The synthesis utilized both naturally occurring and modified amino acids; the modified amino...
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5529989 |
Pancratistatin prodrug
Pancratistatin has been selected for pre-clinical development but is sparingly soluble in water. A disodium phosphate derivative has been synthesized which is water soluble and is bioequivalent...
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5521284 |
Human cancer inhibitory pentapeptide amides and esters
The isolation, elucidation and synthetic replication of novel pentapeptide mides and esters are described. The compounds have the general structure ##STR1## in which R1 and R2 are selected as shown...
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5519050 |
Isolation and structural elucidation of halistatin 3
The Micronesian marine sponge Phakellia sp. has been found to contain cern key members of the antineoplastic halichondrin/halistatin family. These compounds include halichondrin B, homohalichondrin...
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5518970 |
Nitride glasses and methods of making same
The present invention relates generally to a novel and unique class of gly materials and methods of making such materials in which substantially all of the anions are nitride ions, in contrast to...
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5509300 |
Non-contact force microscope having a coaxial cantilever-tip configuration
The present invention comprises a highly sensitive non-contact force microscope having a coaxial cantilever-tip configuration and a method of forming such configuration. The non-contact microscope...
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5506073 |
Lithium ion conducting electrolytes
A liquid, predominantly lithium-conducting, ionic electrolyte having exceptionally high conductivity at temperatures of 100° C. or lower, including room temperature, and comprising the lithium ...
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5504191 |
Human cancer inhibitory pentapeptide methyl esters
Herein disclosed are several pentapeptide methyl ester derivatives of dolatin 10, using both naturally occurring and modified amino acids. The selected modified amino acids are constituents of...
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5494893 |
Stylostatin 2
The cytostatic cycloheptapeptide stylostatin 2 was isolated respectively, from the South and Western Pacific Ocean sponges Stylotella sp. and Phakellia costata. Structural determination was...
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5484670 |
Lithium ion conducting ionic electrolytes
A liquid, predominantly lithium-conducting, ionic electrolyte is described which has exceptionally high conductivity at temperatures of 100° C. or lower, including room temperature. It comprises ...
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5455211 |
Methods of making nitride glasses
The present invention relates generally to a novel and unique class of gly materials and methods of making such materials in which substantially all of the anions are nitride ions, in contrast to...
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5430053 |
Isolation and structure of dictyostatin 1
A new-type of macrocyclic lactone denominated "dictyostatin 1" bearing a membered ring system is isolated from a Republic of Maldives marine sponge in the genus Spongia sp. and found to strongly...
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5426194 |
Isolation and structure of Halistatin 1
An intensive long-term investigation of marine organisms as sources of new anticancer drugs has led to the isolation and structural elucidation (primarily by high field NMR and mass spectrometry)...
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5410024 |
Human cancer inhibitory pentapeptide amides
The synthesis of useful peptides presents a promising approach to new theeutic agents. The Dolastatins, a series of linear and cyclic antineoplastic and/or cytostatic peptides isolated from Indian...
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5409953 |
Isolation, structural elucidation and synthesis of novel antineoplastic substances denominated "combretastatins"
New antineoplastic substances have been isolated, structurally elucidated and synthesized having a general structural formula of: ##STR1## wherein: R1 is OH or OCH3 ; R2 is H or OCH3 ; or R1 R2 is...
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5393897 |
Isolation and structure of spongistatins 5,7,8 and 9
A Southwest Indian Ocean marine sponge Spirastrella spinispirulifera (bri colored reds and purples) has been found to contain new and exceptionally active cell (human cancer) growth inhibitors...
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