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US20120128690 |
METHODS FOR DETERMINING AGENTS THAT TREAT OR PREVENT OBESITY AND/OR OBESITY RELATED DISEASES AND METHODS FOR TREATMENT THEREWITH
The present invention provides methods for determining a putative agent that treats or prevent obesity and/or obesity related diseases comprising contacting cells with the putative agent and...
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8173662 |
Fused pyrimidines as inhibitors of nucleoside phosphorylases and nucleosidases
The present invention relates to compounds of the general formula (I) which are inhibitors of purine muclioside phosphorylases (PNP), purine phosphoribosyltransferases (PPRT),...
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8173604 |
Inhibition of Skp2-cyclin a interaction
Methods of killing a cancer cell are provided. Also provided are methods of treating a subject having a cancer. Additionally, compounds are provided that comprise a peptide from about 18 to about...
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8129121 |
Regulation of lipid droplet formation by modulation of FIT1 and FIT2 and uses thereof
This invention provides methods of regulating fat storage in tissue by modulating the levels of Fibrate Induced Transcript 1 (FIT1) and/or Fibrate Induced Transcript 2 (FIT2), as well as diagnostic...
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8114982 |
Multi-microRNA methods and compositions
Provided are DNAs comprising a polynucleotide that encodes at least a first modified miR-30 precursor and a second modified miR-30 precursor. Also provided are vectors comprising the the DNAs,...
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US20120020970 |
METHODS OF EVALUATING PATIENTS
Methods of treating patients and evaluating patients for disease stage and/or severity are disclosed.
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8101191 |
Mycobacterial SecA2 mutants
Provided are mycobacteria comprising (a) a mutation that is not in a SecA2 gene that attenuates the virulence of the mycobacteria in a mammalian host, and (b) a mutation in a SecA2 gene that...
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8084041 |
Use of mycrobacterial vaccines in CD4+ or CD8+ lymphocyte-deficient mammals
Methods of treating a mammal that is deficient in CD4+ and/or CD8+ lymphocytes are provided. The methods comprise inoculating the mammal with an attenuated mycobacterium in the M. tuberculosis...
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8076318 |
Caged ligands and uses thereof
Provided are caged compounds comprising a ligand that specifically reacts with a receptor not naturally present in mammals. The cage is released from the ligand upon illumination of the compound...
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8071546 |
Uses of pegylated albumin
The present invention is directed to uses of PEGylated albumins which include methods of treating reduced functional capillary density, reduced blood volume, septic shock and cardiac arrhythmia in...
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8071348 |
Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof
The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid...
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8048635 |
Measurement of soluble Tweak levels for evaluation of lupus patients
Methods of treating patients and evaluating patients for disease stage and/or severity are disclosed.
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8030926 |
Surface coil arrays for simultaneous reception and transmission with a volume coil and uses thereof
This invention provides arrays of counter rotating current surface coils for simultaneous reception and transmission with a volume coil for improved signal-to-noise ratio and radio frequency field...
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8022043 |
Ceramide derivatives as modulators of immunity and autoimmunity
α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the anti...
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8003332 |
Inhibition of membrane fusion proteins
Methods of inhibiting viral infection of a eukaryotic cell by a target virus having a class II virus fusion protein are provided. Also provided are methods of screening a test compound for the...
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7998471 |
Mycobacteria expressing HIV-1 and malaria antigens
Provided are recombinant mycobacteria expressing an HIV-1 antigen and a malarial antigen. Also provided are Mycobacterium smegmatis expressing an HIV-1 antigen. Further provided are vaccines...
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US20110178102 |
SIR2 REGULATION
Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation...
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US20110171223 |
Anti-peptide antibodies that cross react with protective antigen of bacillus anthracis and uses thereof
The present invention provides a purified peptide comprising at least one of the sequences LKQKSSNSRKKRSTS (SEQ ID NO:1), or VKNKRTFLSPWISNI (SEQ ID NO:2) as well as a vaccine, a method to protect...
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7939089 |
Attenuated mycobacteria as vectors for gene delivery to mammalian cells
Provided are mycobacteria comprising a recombinant gene operably liked to a mammalian promoter that directs expression of the recombinant gene from a mammalian cell. Also provided are mammalian...
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7902330 |
Protein kinase inhibitors and methods for identifying same
Inhibitors of protein kinase C (PKC)α, PKCδ and PKCζ are provided which are selective for those PKC isotypes. Combinatorial libraries for identifying protein kinases are also provided, as are me...
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US20110053146 |
COMPOUNDS AND METHODS FOR DETECTING RICIN AND USES THEREOF
This application provides fluorescent probes, substrates, kits and methods for detecting the presence or absence of an enzyme, such as ricin, that catalyzes the release of adenine from a GAGA RNA...
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7888025 |
Intestinal folate transporter method
Provided is an isolated and purified DNA molecule comprising the coding region of a PCFT cDNA. Also provided is a segment of the above DNA molecule, capable of serving as a primer for amplifying at...
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7863499 |
Model of infantile spasm syndrome
Provided are non-human mammals treated with doxorubicin, lipopolysaccharide (LPS), and p-chlorophenylalanine (PCPA), where the mammal exhibits a symptom characteristic of infantile spasms. Also...
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US20100324148 |
VITAMIN K FOR PREVENTION AND TREATMENT OF SKIN RASH SECONDARY TO ANTI-EGFR THERAPY
The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a...
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7846680 |
Detection of the nucleolar channel system of human endometrium and uses thereof
Methods are disclosed for assaying at the light microscopic level for the presence or absence of nucleolar channel systems (NCSs) in an endometrial tissue sample, as are methods for determining...
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7846677 |
Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1 (INI1)/hSNF5
Peptides comprising an Rpt1 domain of an INI1/hSNF5 which inhibit HIV-1 production in a human cell, and vectors encoding those peptides are provided. Also provided are methods of inhibiting HIV-1...
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US20100297185 |
MYCOBACTERIAL MUTANTS AFFECTING HOST APOPTOSIS
Provided are recombinant mycobacteria having a mutation in an nlaA gene or in a nuoG gene. Also provided are isolated and purified nlaA proteins and nuoG proteins from a mycobacterium. Additionally...
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7820401 |
Collagen VI and cancer
Methods of determining whether a cancer is progressing by measuring surface-bound collagen VIα3 are provided. Also provided are methods of identifying hyperplasia in a tissue by measuring ...
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7816384 |
Method for treating a demyelinating condition
Methods for treating a demyelinating condition in a subject in need of treatment are provided. In some aspects the methods encompass administering to the subject an amount of a Ca2+-channel blocker...
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7795394 |
Saitohin gene and uses of same
The present invention provides an isolated nucleic acid sequence encoding saitohin (STH), an isolated nucleic acid sequence that hybridizes to said sequence, and a purified protein encoded by said...
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US20100226919 |
Antitumoral Treatments
The present invention relates to combinations of PM02734 with EGFR tyrosine kinase inhibitors, and the use of these combinations in the treatment of cancer.
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7777025 |
Transition state analog inhibitors of ricin A-chain
Improved transition state analog inhibitors of ricin toxin-A are provided. Methods of using those inhibitors to inhibit ricin toxin-A and to prevent the toxic effects of ricin toxin-A in a mammal...
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7772380 |
Ceramide derivatives as modulators of immunity and autoimmunity
α-Galactosylceramides and glycosylceramides (“ceramide-like glycolipids”) that modulate NK T cells. The ceramide-like glycolipids vary in the cytokines induced in NK T cells and vary in the anti...
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US20100183549 |
BACTERIAL VACCINES WITH CELL WALL-ASSOCIATED CERAMIDE-LIKE GLYCOLIPIDS AND USES THEREOF
The invention is directed compositions and methods related to bacterial cells physically associated with ceramide-like glycolipids. The invention allows for delivery of ceramide-like glycolipid...
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7759459 |
Fluorescent assays for protein kinases
This invention provides fluorescently-labeled peptide substrates for protein kinases; methods using the substrates for identifying compounds that inhibit protein kinases, for determining if...
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7759118 |
Proliferation of hepatocyte precursors
A composition which comprises an animal cell population which contains immature animal cells. The immature animal cells are characterized by expression of alpha-fetoprotein or lack of essential...
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7758874 |
Attenuated Mycobacterium tuberculosis vaccines
Non-naturally occurring mycobacteria in the Mycobacterium tuberculosis complex are provided. These mycobacteria have a deletion of an RD1 region or a region controlling production of a vitamin, and...
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7745494 |
Vitamin K for prevention and treatment of skin rash secondary to anti-EGFR therapy
The invention provides methods and compositions for treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (EGFR) therapy, where the method comprises applying a...
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7745163 |
Method for identifying acetyltransferase substrates
The present invention is directed to a method of identifying an acetyltransferase substrate in a sample that includes the steps of: (a) contacting the sample with (i) a reagent comprising a...
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7741295 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from 2′-O-ac...
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7736911 |
Activity-based probes for protein tyrosine phosphatases
Provided are compounds capable of covalently binding to a protein tyrosine phosphatase (PTP). The compounds comprise Formula A: Also provided are compositions comprising one of the above compounds...
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7709613 |
Rhenium-188 and rhenium-186 for treatment of tumors expressing a Na+/I− symporter
This invention provides methods of using Rhenium radioisotopes to detect and treat tumors that express a Na+/I− symporter. The invention also provides compositions and methods of making c...
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US20100104548 |
MODULATION OF AMINO ACID METABOLISM IN THE HYPOTHALAMUS
Methods for reducing peripheral blood glucose levels, food intake, glucose production, gluconeogenesis, triglyceride levels, and low density lipoprotein (VLDL) levels in mammals are provided. Also...
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7705016 |
Regulation of food intake by modulation of long-chain fatty acyl-CoA levels in the hypothalamus
Methods of reducing food intake and glucose production in a mammal, or restoring hepatic autoregulation are provided. The methods involve increasing long-chain fatty acyl-Co-A (LC-CoA) levels in...
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7700759 |
Aptamer constructs
Provided are RNA oligonucleotides having an aptamer flanked by two self-cleaving ribozymes. Vectors encoding the oligonucleotides, and cells transfected with these vectors are also provided....
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7678888 |
Stable oxidation resistant powdered hemoglobin, methods of preparing same, and uses thereof
The present invention provides oxygenated hemoglobins in powdered form and methods of preparing a powdered form of a protein, such as hemoglobin, which comprise (a) mixing a solution of the protein...
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US20100035823 |
LIGANDS OF SH3 DOMAINS
Provided are compounds that bind to SH3 domains. Also provided are combinatorial libraries for discovering such compounds. Methods of identifying a compound that binds to an SH3 domain are also...
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7651689 |
Methods of applying ionization radiation for therapy of infections
This invention provides methods for treating infections in a subject which comprise administering to the subject an amount of a radiolabeled antibody effective to treat the infection, wherein the...
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7609060 |
Non iterative shimming in magnetic resonance imaging in the presence of high LIPID levels
For the brain, a variety of automated non-iterative shimming methods using phase evolution derived B0 maps have been reported. These methods assume that there is only a single chemical species...
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US20090239952 |
VITAMIN K FOR PREVENTION AND TREATMENT OF SKIN RASH SECONDARY TO ANTI-EGFR THERAPY
The invention provides methods and compositions tor treating and preventing a skin rash secondary to anti-epidermal growth factor receptor (BGKR) therapy, where the method comprises applying a...
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