Patents and Patent Applications from Albert Einstein College of Medicine Yeshiva University


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9782441 Stromal cell therapy in treatment of radiation injury  
Methods are provided for treating, mitigating or protecting from radiation-induced injury using bone marrow stromal cells expanded in culture, adipose-tissue derived non-adherent stromal cells, or...
US20170246215 REPOPULATION OF ORGANS AND TISSUES USING A YAP-ERT2 FUSION PROTEIN  
Provided herein are methods for the repopulation of organs and tissues, such as the liver, using modified cells that express a transcription coactivation factor-ligand binding domain fusion...
9737511 Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux  
One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a subject in need of such treatment or...
9730947 Method of treating lupus nephritis  
Methods of treating patients and evaluating patients for disease stage and/or severity are disclosed.
9719142 Metastasis specific splice variants of Mena and uses thereof in diagnosis, prognosis and treatment of tumors  
Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
US20170204166 THERAPY FOR FILOVIRUS INFECTION  
The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody...
US20170202952 RECOMBINANT HERPES SIMPLEX VIRUS 2 (HSV-2) VACCINE VECTORS  
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.
9695193 Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds  
Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type 1 are identified and methods of use as anti-parasitic compounds are provided.
US20170182163 MULTI-SPECIFIC ANTIBODIES FOR CROSS-NEUTRALIZATION OF MULTIPLE FILOVIRUS GLYCOPROTEINS  
Methods for treating and for preventing Filovirus infections are disclosed, as well as compositions therefor.
9688991 Aptamer-targetted antigen delivery  
A composition is provided comprising an oligonucleotide aptamer conjugated to an antigen, wherein the aptamer is directed against a cell-surface target of an antigen-presenting cell. Also provided...
US20170176435 CELLULAR PLATFORM FOR RAPID AND COMPREHENSIVE T-CELL IMMUNOMONITORING  
Methods and systems for the efficient and systematic identification of the repertoire of T-cell epitopes.
US20170174742 TMIGD2 AND ITS DERIVATIVES AS BLOCKERS OR BINDERS OF CANCER-EXPRESSED HHLA2 FOR IMMUNOTHERAPIES  
Provided are methods of treating an HHLA2-bearing tumor in a subject with a fusion protein comprising an IgV-like domain of a TMIGD2 sufficient to treat the HHLA2-bearing tumor. A fusion protein...
US20170173141 METHODS AND ASSAYS FOR TREATING HANTAVIRUS INFECTIONS  
Methods and assays are disclosed for treating a subject with a hantavirus infection using an agent that binds to proto cadhenn-1 (PCDH1) or inhibits expression of protocadherin-1 (PCDH1).
US20170166573 3-HYDROXYPYRROLIDINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE  
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The...
US20170166571 TREATMENT OF H. PYLORI INFECTIONS USING MTAN INHIBITORS  
Methods of treating infections due to Helicobacter pylori (H. pylori), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering inhibitors of H....
9671391 IL-34 receptor assays and uses thereof  
Methods are disclosed for identifying activators and inhibitors of actions of interleukin-34 (IL-34) that are independent of the colony stimulating factor-1 (CSF-1) receptor (CSF-1R) and play a...
US20170128416 ORAL ADMINISTRATION OF MELANIN FOR PROTECTION AGAINST RADIATION  
Methods and compositions are provided for alleviating and/or preventing one or more side effects associated with exposure to radiation in a subject exposed to radiation or at risk for exposure to...
US20170119814 THERAPEUTIC NANOPARTICLES AND METHODS THEREOF  
Described herein is a method of preparing a hybrid hydrogel paramagnetic nanoparticle. In certain embodiments, the hybrid hydrogel paramagnetic nanoparticle comprises a therapeutic agent. In...
9637749 Mycobacterium tuberculosis ΔESX-3 mutants  
Isolated mutant Mycobacterium tuberculosis bacteria comprising a deletion in the ESAT-6 gene cluster region 3 (esx-3 region) are provided, as well as compositions comprising such, methods of...
9636419 Targeting multiple receptors on a cell surface for specific cell targeting  
A method of delivering a cargo agent into cytosol of a cell can include: providing the delivery system of one of the embodiments described herein having the first and second delivery platforms;...
US20170114128 USE OF TGF-BETA ANTAGONISTS OF TREAT TYPE-2 DIABETES  
Method and compositions for treating type-2 diabetes in a subject are provided comprising administering to the subject an amount of an inhibitor of a TGF-beta.
US20170114100 TARGETING DIMERIZATION OF BAX TO MODULATE BAX ACTIVITY  
Methods are provided for identifying an agent that directly modulates a Bcl-2- associated x-protein (BAX) by promoting or disrupting dimerization of the BAX. Agents that directly modulate BAX by...
US20170105407 COMPOSITIONS AND METHODS FOR ENHANCING RED BLOOD CELL STORAGE TIME AND SURVIVABILITY USING NITRIC OXIDE RELEASING HYBRID HYDROGEL NANOPARTICLES  
Described herein are hydrogel-based nanoparticles which release nitric oxide (NO) or other bioactive forms of NO including nitrosothiols, nitrofatty acids and dinitrogen trioxide into stored red...
US20170088606 THERAPY FOR FILOVIRUS INFECTION  
The present invention addresses a need for improved treatments for Filovirus infections.
9603852 Treatment of obesity and pulmonary arterial hypertension  
Disclosed are methods and compositions for treating pulmonary arterial hypertension and/or obesity using inhibitors of prostaglandin transporter (PGT) activity.
US20170073677 TREATMENT OF MULTIPLE SCLEROSIS BY INHIBITION OF ALLOGRAFT INFLAMMATORY FACTOR-1  
Methods are disclosed for treating multiple sclerosis comprising administering an agent that reduces expression and/or activity of Allograft inflammatory factor-1 (Aif-1) in a subject and for...
US20170065182 REVERSIBLY SWITCHABLE PHOTOACOUSTIC IMAGING SYSTEMS AND METHODS  
Reversibly switchable photoacoustic tomography (RS-PAT), a photoacoustic technique with enhanced sensitivity and resolution, is disclosed. RS-PAT utilizes a subtractive process for the formation...
US20170058015 SYNTAC POLYPEPTIDES AND USES THEREOF  
Methods and compositions for clonally inhibiting or clonally stimulating T-cells are provided.
US20170056381 PYRIDOXAMINE FOR THE TREATMENT OF SICKLE CELL DISEASE, THALASSEMIA AND RELATED BLOOD DISEASES  
The present invention relates to treatments and therapies for anemia conditions and diseases of the blood, and more particular is a therapy for the acute and chronic treatment of sickle cell...
US20170037039 RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF  
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or...
US20170029525 ANTIBODIES TO HUMAN B7X FOR TREATMENT OF METASTATIC CANCER  
Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the...
US20170014651 METHOD OF DIAGNOSIS AND TREATMENT OF TUMORS USING HIGH INTENSITY FOCUSED ULTRASOUND  
A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a...
9540646 Cellular targets for HIV infection  
Methods and compositions are provided for treating HIV infection and for inhibiting HIV infection, and for identifying purinergic receptor antagonists or Panx 1 hemi-channel blockers useful...
9540412 Methods of preparing targeted aptamer prodrugs  
The present invention provides methods of preparing an oligonucleotide, nucleoside or nucleoside analog for selective introduction into a subject's cells, the method comprising (1) selecting a...
9522159 Treatment and prevention of P. aeruginosa infections using coformycin analogs  
Methods and devices are disclosed for treating or preventing infections in a subject due to Pseudomonas aeruginosa using coformycin analogs and inhibitors of Pseudomonas aeruginosa...
US20160356779 METHODS OF GRADING CARCINOMAS  
Methods for grading carcinomas are provided as well as kits therefor. A method is provided for grading a carcinoma, or suspected carcinoma, comprising obtaining a sample of the carcinoma or...
9512092 Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof  
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or...
9511097 Regeneration of coronary artery by coronary endothelial specific progenitor cells  
Methods and products are provided for producing an artery-specific endothelial cell. Also provided are methods for treating a tumor in a subject.
US20160346389 MODIFIED PARAMAGNETIC NANOPARTICLES FOR TARGETED DELIVERY OF THERAPEUTICS AND METHODS THEREOF  
Described herein is a method of making modified paramagnetic nanoparticles with improved therapeutic loading efficiency and enhanced circulation properties. The method comprises coating a...
US20160346384 MODIFIED GLYCOLIPIDS AND METHODS OF MAKING AND USING THE SAME  
The invention is directed to compositions and methods related to proteins that are physically associated with ceramide-like glycolipids for use as activators of NKT cells. The compositions and...
US20160340737 EPIGENETIC STEM CELL COMMITMENT-ASSOCIATED SIGNATURE  
Methods for determining the prognosis of a subject having acute myeloid leukemia (AML) as well as methods of treating AML subjects depending on prognosis.
9498537 Method of enhancing efficacy of blood transfusions  
A method of improving the efficacy of a blood transfusion into a subject is provided comprising administering a composition comprising an EAF PEGylated-blood protein into the subject, prior to,...
US20160333061 FUSION TAGS FOR PROTEIN EXPRESSION  
Fluorescent and non-fluorescent fusion tags derived from green fluorescent protein (GFP). The fusion tags harbor substitutions with respect to GFP that increase expression of target proteins to...
9493465 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase  
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (I) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The...
US20160304857 METHOD OF RAPID ISOLATION OF APTAMER BEACONS  
Methods and compositions are provided for rapidly identifying novel structure-switching aptamers.
US20160304581 B7X AND ITS DERIVATIVES FOR TREATING AND PREVENTING CARDIOVASCULAR DISEASE  
Methods are disclosed for preventing and/or treating cardiovascular diseases comprising administering B7x or a derivative of B7x to a patient in need thereof.
US20160298165 METHOD OF TREATING TUBERCULOSIS  
The present invention addresses a need for improved methods of treating M. tuberculosis infection using enhancers of respiration, and compositions for treating tuberculosis as well as assays for...
US20160287130 PISTON DEVICE FOR MAGNETIC RESONANCE ELASTOGRAPHY AND USES THEREOF  
Disclosed are piston actuator devices and their uses for magnetic resonance elastography (MRE).
9457202 Method of diagnosis and treatment of tumors using high intensity focused ultrasound  
A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a...
9447449 Recombinant mycobacteriophages for delivery of nucleic acids of interest into mycobacteria  
Methods are provided for detecting mycobacteria in a sample, including clinical samples. Methods are also provided for determining susceptibility of mycobacterial strains to known or potential...