Patents and Patent Applications from Albert Einstein College of Medicine Yeshiva University


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9994845 Methods and compositions to inhibit metastasis and to treat fibrosis and to enhance wound healing  
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing,...
US20180154073 MICROFLUIDIC INTRAVITAL WINDOW  
A microfluidic intravital window includes an intravital imaging window adapted for implantation adjacent target tissue of a live animal, and a microfluidic fluid source and delivery system...
US20180148782 METHODS OF DETERMINING LEVELS OF EXPOSURE TO RADIATION AND USES THEREOF  
Provided herein are methods of determining a subject's level of exposure to radiation and methods of determining a subject's risk of subsequent development of radiation disease or risk of poor...
US20180148686 INTERVENTION FOR TENDINOPATHY  
Methods for treating tendinopathy and tendonitis and for preventing tendinopathy are disclosed.
US20180141999 ANTIBODY THERAPEUTICS AGAINST FILOVIRUS INFECTIONS AND USES THEREOF  
Disclosed are bispecific antibodies and bispecific fusion constructs that bind to Niemann-Pick CI (NPC1) receptor for treating or preventing filovirus infections, pharmaceutical compositions...
US20180141937 RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF  
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or...
9970057 Human invasion signature for prognosis of metastatic risk  
Methods and products are provided for determining if a subject having a tumor is (i) at risk of metastasis of the tumor, or (ii) at risk of recurrence of the tumor after treatment of the tumor....
9957272 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase  
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The...
US20180106811 TMEM ACTIVE TEST AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS  
Disclosed are kits and methods for detecting the presence of tumor sites that are active in tumor cell dissemination and uses thereof for determining the risk of tumor cells undergoing...
US20180105863 NEURAL STEM CELL THERAPY FOR OBESITY AND DIABETES  
Methods are provided of treating obesity or an obesity comorbidity in a mammalian subject comprising administering to the subject an amount of an agent effective to treat obesity or the obesity...
US20180104320 TREATMENT OF CANCER USING RECALL ANTIGENS DELIVERED BY ATTENUATED BACTERIA  
Methods, pharmaceutical compositions and vaccines comprising an attenuated bacteria that expresses a recall antigen are disclosed for treatment of cancer.
9926601 Alternatively spliced mRNA isoforms as prognostic indicators for metastatic cancer  
The present invention provides a method for identifying a tumor as likely to metastasize, or likely to have metastasized, comprising obtaining a sample of the tumor and quantitating alternatively...
9925222 Gut barrier dysfunction treatment and prevention  
Methods are disclosed for treating and preventing gut barrier dysfunction or an illness associated with gut barrier dysfunction in a subject comprising administering to the subject bacterium that...
9920102 Fusion tags for protein expression  
Fluorescent and non-fluorescent fusion tags derived from green fluorescent protein (GFP). The fusion tags harbor substitutions with respect to GFP that increase expression of target proteins to...
US20180074049 METHODS AND COMPOSITIONS FOR RAPID FUNCTIONAL ANALYSIS OF GENE VARIANTS  
Methods and compositions are disclosed for rapid functional analysis of gene variants based on analysis of protein-protein and protein-nucleic acid interactions.
US20180071265 Method of Treating or Preventing Pathologic Effects of Acute Increases in Hyperglycemia and/or Acute Increases of Free Fatty Acid Flux  
One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a subject in need of such treatment or...
9915657 Lateral flow device for diagnosing microbial infections  
Fungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carries with it a high mortality. Culture of the organism is difficult and obtaining...
9914926 Fidgetin-like 2 as a target to enhance wound healing  
Methods of treating a wound in a subject are provided comprising administering to the subject an amount of an inhibitor of Fidgetin-like 2. Compositions and pharmaceutical compositions comprising...
9907982 Method of diagnosis and treatment of tumors using high intensity focused ultrasound  
A method of diagnosis and treatment of tumors using High Intensity Focused Ultrasound is provided. The method of diagnosing the presence of a tumor in a patient comprises the steps of subjecting a...
US20180057816 METHODS AND COMPOSITIONS TO INHIBIT METASTASIS AND TO TREAT FIBROSIS AND TO ENHANCE WOUND HEALING  
Methods and compositions are provided for inhibiting or treating metastasis based on discoveries regarding Kif19 and Cep192. Methods and compositions are provided for enhancing wound healing,...
US20180055877 THERAPEUTIC NANOPARTICLES AND METHODS THEREOF  
Described herein is a method of preparing a hybrid hydrogel paramagnetic nanoparticle. In certain embodiments, the hybrid hydrogel paramagnetic nanoparticle comprises a therapeutic agent. In...
US20180044383 MONOMERIC NEAR-INFRARED FLUORESCENT PROTEINS ENGINEERED FROM BACTERIAL PHYTOCHROMES AND METHODS FOR MAKING SAME  
Nucleic acid molecules encoding monomeric near-infrared fluorescent proteins, variants and derivatives thereof are provided, as well as proteins and peptides encoded by these nucleic acids. Also...
9890143 Retinoic acid receptor antagonists as chaperone-mediated authophagy modulators and uses thereof  
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or...
9880173 Pyrite shrink-film laminate as a hydroxyl radical generator  
Disclosed are hydroxyl radial generating devices, comprising: a substrate layer; and a pyrite layer configured to produce hydroxyl radicals. Another aspect relates to a method for producing a...
9873918 Treatment of acute myeloid leukemia and myelodysplastic syndromes  
Methods are disclosed for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes using interleukin 1 receptor accessory protein and other targets.
9857378 Tuberculosis biomarkers and uses thereof  
The present invention provides biomarkers, methods and kits for diagnosing active tuberculosis in a subject, methods and kits for monitoring the effectiveness of treatment for active TB, as well...
9841424 Serologic test for the rapid diagnosis of active tuberculosis  
The present invention relates to methods and kits for detecting active tuberculosis infection in a subject using serological techniques and a first agent capable of binding an IgG, IgA and/or IgM...
US20170335406 METASTASIS SPECIFIC SPLICE VARIANTS OF MENA AND USES THEREOF IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF TUMORS  
Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
US20170333578 METHOD FOR PRODUCING RADIOBACTERIA FOR THERAPY OF CANCER  
A method of producing radiobacteria is provided, especially radiolisteria-32P. Compositions and methods of use thereof are also provided.
US20170332910 MODIFIED PARAMAGNETIC NANOPARTICLES FOR TARGETED DELIVERY OF THERAPEUTICS AND METHODS THEREOF  
Described herein is a method of inducing vascular inflammation using modified paramagnetic nanoparticles with improved therapeutic loading efficiency and enhanced circulation properties. The...
9809560 Ligands and methods for labeling biomolecules in vivo  
Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods for labeling and/or imaging a biomolecule of interest in a subject or living system.
US20170304200 PROGRAMMED CARGO RELEASE USING NUCLEIC ACID-STABILIZED MICELLES  
Methods and compositions for serum-stabilizing micelles for drug delivery or imaging agent delivery are provided, as well as methods and compositions to enhance micelle-mediated drug delivery....
US20170299600 METHODS AND COMPOSITIONS FOR ASSESSING GERMLINE RISK OF CANCER  
Heritable mutations in the BRCA1 and BRCA2 and other genes in the DNA double-strand break (DSB) repair pathway increase risk of breast, ovarian and other cancers. In response to DNA breaks, the...
US20170299573 HOST AND INTESTINAL MICROBIOTA DERIVED METABOLOMIC BLOOD PLASMA SIGNATURE FOR PRIOR RADIATION INJURY  
Provided are methods of determining prior radiation dose exposure levels for subjects, and kits therefor. Also provided are methods of treatment.
9782441 Stromal cell therapy in treatment of radiation injury  
Methods are provided for treating, mitigating or protecting from radiation-induced injury using bone marrow stromal cells expanded in culture, adipose-tissue derived non-adherent stromal cells, or...
US20170277766 SEMANTIC INDEXING ENGINE  
Embodiments are described for a method of distributing n-tuples over a cluster of triple-store machines, by storing each n-tuple as text in a distributed file system using a key value store;...
US20170246215 REPOPULATION OF ORGANS AND TISSUES USING A YAP-ERT2 FUSION PROTEIN  
Provided herein are methods for the repopulation of organs and tissues, such as the liver, using modified cells that express a transcription coactivation factor-ligand binding domain fusion...
9737511 Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases of free fatty acid flux  
One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a subject in need of such treatment or...
9730947 Method of treating lupus nephritis  
Methods of treating patients and evaluating patients for disease stage and/or severity are disclosed.
9719142 Metastasis specific splice variants of Mena and uses thereof in diagnosis, prognosis and treatment of tumors  
Methods and kits for diagnosis, prognosis and treatment of metastatic tumors are provided where the metastatic tumor is characterized by changes in expression of +++, ++ and/or 11a variants of Mena.
US20170204166 THERAPY FOR FILOVIRUS INFECTION  
The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody...
US20170202952 RECOMBINANT HERPES SIMPLEX VIRUS 2 (HSV-2) VACCINE VECTORS  
Recombinant herpes simplex virus 2 (HSV-2) vaccine vectors, virions thereof, compositions and vaccines comprising such, and methods of use thereof are each provided.
9695193 Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type I as anti-parasitic compounds  
Inhibitors of Plasmodium falciparum equilibrative nucleoside transporter type 1 are identified and methods of use as anti-parasitic compounds are provided.
US20170182163 MULTI-SPECIFIC ANTIBODIES FOR CROSS-NEUTRALIZATION OF MULTIPLE FILOVIRUS GLYCOPROTEINS  
Methods for treating and for preventing Filovirus infections are disclosed, as well as compositions therefor.
9688991 Aptamer-targetted antigen delivery  
A composition is provided comprising an oligonucleotide aptamer conjugated to an antigen, wherein the aptamer is directed against a cell-surface target of an antigen-presenting cell. Also provided...
US20170176435 CELLULAR PLATFORM FOR RAPID AND COMPREHENSIVE T-CELL IMMUNOMONITORING  
Methods and systems for the efficient and systematic identification of the repertoire of T-cell epitopes.
US20170174742 TMIGD2 AND ITS DERIVATIVES AS BLOCKERS OR BINDERS OF CANCER-EXPRESSED HHLA2 FOR IMMUNOTHERAPIES  
Provided are methods of treating an HHLA2-bearing tumor in a subject with a fusion protein comprising an IgV-like domain of a TMIGD2 sufficient to treat the HHLA2-bearing tumor. A fusion protein...
US20170173141 METHODS AND ASSAYS FOR TREATING HANTAVIRUS INFECTIONS  
Methods and assays are disclosed for treating a subject with a hantavirus infection using an agent that binds to proto cadhenn-1 (PCDH1) or inhibits expression of protocadherin-1 (PCDH1).
US20170168056 METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING CANCER CELLS  
The present disclosure provides methods of treatment and compositions for improving and determining the efficacy of anti-cancer therapies involving tubulin remodeling or protein tyrosine kinase...
US20170166573 3-HYDROXYPYRROLIDINE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND NUCLEOSIDASE  
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5′-methylthioadenosine phosphorylase or 5′-methylthioadenosine nucleosidase. The...