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US20170296645 Immunogenic Proteins and Compositions  
The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS)
US20170291958 Compositions and Methods For the Modulation of Ras Proteins  
Described herein is a method of modulating sumoylation of a Ras protein by small ubiquitin-like modifier (SUMO) proteins. Provided herein is a method for regulating the activity of a Ras protein....
US20170283488 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS  
Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (SSEA-4) are disclosed herein, as well as methods of use...
US20170283475 CANCER VACCINE COMPOSITIONS AND METHODS OF USE THEREOF  
The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The compositions described herein include...
US20170281759 BISPHOSPHONATE-CONTAINING VACCINE PHARMACEUTICAL COMPOSITION FOR HUMORAL IMMUNITY  
The present invention aims to provide a vaccine pharmaceutical composition universally usable for induction of humoral immunity against various antigens and exerting a high antibody production...
9771399 Immunogenic bacterial vesicles with outer membrane proteins  
Knockout of the meningococcal mltA homolog gives bacteria that spontaneously release vesicles that are rich in immunogenic outer membrane proteins and that can elicit cross-protective antibody...
9770463 Delivery of RNA to different cell types  
RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the...
US20170266297 PHARMACEUTICAL COMPOSITIONS COMPRISING IMIDAZOQUINOLIN(AMINES) AND DERIVATIVES THEREOF SUITABLE FOR LOCAL ADMINISTRATION  
The present invention relates in general to the field of modulators of the innate immune system, particularly to pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives...
US20170266268 VACCINATION IN NEWBORNS AND INFANTS  
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age...
9764031 Dose selection of adjuvanted synthetic nanocarriers  
Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
9764027 Outer membrane vesicles  
The present invention provides an outer membrane vesicle (OMV) from a Gram-negative bacterium, comprising at least one heterologous protein that is free in the lumen of the OMV, wherein the OMV is...
9757443 Non-lipidated variants of Neisseria meningitidis ORF2086 antigens  
The present invention relates to compositions including an isolated non-pyruvylated non-lipidated ORF2086 polypeptide, and methods thereof. In an exemplary embodiment, the compositions described...
US20170252430 POLYMERIC CARRIER CARGO COMPLEX FOR USE AS AN IMMUNOSTIMULATING AGENT OR AS AN ADJUVANT  
The present invention is directed to a polymeric carrier cargo complex, comprising as a cargo at least one nucleic acid molecule and as a preferably non-toxic and non-immunogenic polymeric carrier...
9750690 Circulation of components during microfluidization and/or homogenization of emulsions  
An improved method for the manufacture of an oil-in-water emulsion involves circulation of emulsion components between a first container and a second container via a homogenizer and/or via a...
US20170246290 OIL-IN-WATER EMULSION INFLUENZA VACCINE  
The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant...
US20170246287 VACCINE COMPOSITION FOR TRANSDERMAL ADMINISTRATION  
Disclosed is a vaccine composition for transdermal administration to induce cellular immunity, comprising an antigen, wherein Th1 cell ratio in a model animal for immunological evaluation that...
US20170246285 Conjugation of Streptococcal Capsular Saccharides  
Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive amination of oxidized sialic acid residue side chains is used, but the...
9744231 Quality control methods for oil-in-water emulsions containing squalene  
Measurements of the squalene content in oil-in-water emulsions can be used as a way of checking for problems during production. In particular, it has been found that a drop in squalene content can...
9744228 Method for generating a parvovirus B19 virus-like particle  
The invention provides a process for generating parvovirus VP1/VP2 virus like particles (VLPs). The invention further provides methods for purification of the parvovirus VLPs and immunogenic...
US20170239342 Methods for Enhancing Efficacy of a Vaccine by Administering an IL-4R Antagonist  
The present invention provides methods for enhancing the efficacy and/or safety of a vaccine. In certain embodiments, the invention provides methods to increase or potentiate the immune response...
9737595 Combination of vaccination and inhibition of MHC class I restricted antigen presentation  
The present invention relates to a vaccine/inhibitor combination comprising as a vaccine at least one antigen and as an inhibitor at least one inhibitor of the major histocompatibility complex...
9737593 Carbon nanotube compositions and methods of use thereof  
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or...
US20170233745 UREIDOPYRIMIDONE SUPRAMOLECULAR COMPLEXES FOR COMPOUND DELIVERY INTO CELLS  
The present invention is directed to particle comprising a supramolecular complex comprising a monofunctional and/or a bifunctional subunit comprising a quadruple hydrogen bonding unit, an apolar...
US20170232101 Polyvalent Pneumococcal Polysaccharide-Protein Conjugate Composition  
Provided is an immunogenic composition comprising 15 different polysaccharide-protein conjugates. Each of the conjugates comprises a capsular polysaccharide prepared from different serotype...
9730999 Adjuvanted influenza virus compositions  
The present invention relates to influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in medicine, in particular their use in augmenting...
US20170226192 METHODS OF MODULATING AN IMMUNE RESPONSE  
The present invention relates to monoclonal antibodies and antigen-binding portions thereof that specifically bind to a filovirus (e.g., Marburg virus (MARV)), including antibodies that...
US20170224616 OIL-IN-WATER EMULSIONS THAT CONTAIN NUCLEIC ACIDS  
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a...
9725488 Immunogenic proteins and compositions  
The invention provides proteins and compositions for the treatment and prevention of Streptococcus agalactiae (Group B streptococcus; GBS).
9724402 Neisseria meningitidis composition and methods thereof  
In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71 in another aspect, the invention relates to an...
US20170218030 RESPIRATORY SYNCYTIAL VIRUS (RSV) VACCINE  
The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment,...
US20170216425 AVOIDING NARCOLEPSY RISK IN INFLUENZA VACCINES  
The invention provides influenza vaccines and methods which improve the safety of influenza vaccines further, in particular in relation to the risk of causing narcolepsy in adjuvanted vaccines.
9718862 Polypeptides and their use in treating and limiting respiratory syncytial virus infection  
The present invention provides polypeptides and compositions thereof for treating or limiting respiratory syncytial virus infection, and computational methods for designing such polypeptides.
US20170209570 Carbon Nanotube Compositions and Methods of Use Thereof  
Carbon nanotube (CNT)-based compositions for activating cellular immune responses are provided. The CNTs function as high surface area scaffolds for the attachment of T cell ligands and/or...
US20170202960 CATIONIC OIL-IN-WATER EMULSIONS  
This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the...
US20170202957 COMPOSITION COMPRISING A COMPLEXED (m)RNA AND A NAKED mRNA FOR PROVIDING OR ENHANCING AN IMMUNOSTIMULATORY RESPONSE IN A MAMMAL AND USES THEREOF  
The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic...
US20170202955 Adjuvanted Influenza Vaccines for Pediatric Use  
An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric...
9709567 Compositions and methods for diagnosing and/or treating influenza infection  
The present invention provides HA polypeptides (e.g., H1 HA polypeptides) that bind to umbrella-topology glycans, and reagents and methods relating thereto. The present invention provides binding...
9708585 Influenza virus reassortment  
New influenza donor strains for the production of reassortant influenza A viruses are provided.
US20170196969 VACCINATION IN NEWBORNS AND INFANTS  
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age...
US20170196968 PROCESS FOR PRODUCING INFLUENZA VACCINE  
A process for producing a split influenza virus preparation or subunit influenza preparation comprising the steps of: (i) providing a whole virus preparation; (ii) splitting the whole virus...
9701720 Epitope-scaffold immunogens against respiratory syncytial virus (RSV)  
The present invention provides polypeptides and compositions thereof for treating or limiting respiratory syncytial virus infection, and computational methods for designing such polypeptides.
9700616 Arranging interaction and back pressure chambers for microfluidization  
An improved method for the manufacture of an oil-in-water emulsion comprises using a microfluidisation device whose interaction chamber comprises a plurality of Z-type channels upstream of a back...
9700605 Vaccine comprising an oil in water emulsion  
The present invention provides an immunogenic composition comprising an antigen or antigen composition and an adjuvant composition comprising an oil in water emulsion, wherein said oil in water...
US20170189503 PCSK9 VACCINE AND METHODS OF USING THE SAME  
A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat...
US20170182150 VACCINATION WITH mRNA-CODED ANTIGENS  
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in an elderly patient preferably exhibiting an age of at...
US20170182137 BREAST AND OVARIAN CANCER VACCINES  
The compositions described herein include an epitope of a peptide that may elicit an immune response in a subject following administration. The compositions may comprise nucleic acids. The...
US20170182081 MANNOSE-CONTAINING SOLUTION FOR LYOPHILIZATION, TRANSFECTION AND/OR INJECTION OF NUCLEIC ACIDS  
The present invention is directed to (the use of) a solution containing at least one nucleic acid (sequence) and free mannose for lyophilization, transfection and/or injection, particularly of RNA...
9688729 Respiratory syncytial virus (RSV) vaccine  
The present invention relates to an mRNA sequence, comprising a coding region, encoding at least one antigenic peptide or protein of RSV infections Respiratory syncytial virus (RSV) or a fragment,...
US20170173128 TARGETED ADAPTIVE VACCINES  
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules for targeted adaptive vaccines (TAVs).
RE46441 Circulation of components during homogenization of emulsions  
An improved method for the manufacture of an oil-in-water emulsion involves circulation of emulsion components between a first container and a second container via a homogenizer and/or via a...

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