AcclaimIP-ad

Match Document Document Title
US20170173128 TARGETED ADAPTIVE VACCINES  
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotide molecules for targeted adaptive vaccines (TAVs).
RE46441 Circulation of components during homogenization of emulsions  
An improved method for the manufacture of an oil-in-water emulsion involves circulation of emulsion components between a first container and a second container via a homogenizer and/or via a...
9675691 Conjugation of streptococcal capsular saccharides  
Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive amination of oxidized sialic acid residue side chains is used, but the...
9675683 Chlamydia antigens  
The invention provides Chlamydia antigens for use in the treatment, prevention and/or diagnosis of Chlamydia infection. In particular, the invention provides antigens CT733, CT153, CT601, CT279,...
US20170157225 COMPLETE GENOME SEQUENCE OF THE METHANOGEN METHANOBREVIBACTER RUMINANTIUM  
The present invention includes the complete genome sequence for the methanogen, Methanobrevibacter ruminantium, including polynucleotides which encode M. ruminantium polypeptides or peptides, as...
9669088 Vaccination with multiple clades of H5 influenza A virus  
H5N1 influenza viruses isolated from animals and humans since 2003 separate into distinct clades based on hemagglutinin amino acid sequences. According to the invention, multiple clades are used...
US20170143816 MUTANT STAPHYLOCOCCAL ANTIGENS  
Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fcγ portion of human IgG is provided.
9655845 Oil-in-water emulsions that contain nucleic acids  
This invention generally relates to cationic oil-in-water emulsions that can be used to deliver nucleic acid molecules, such as an RNA molecule. The emulsion particles comprise an oil core and a...
9642904 Compositions for immunising against Staphylococcus aureus  
An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides...
US20170119871 LOW-ADDITIVE INFLUENZA VACCINES  
An influenza vaccine lacks at least three of: a mercurial preservative; an antibiotic; formaldehyde; and egg-derived materials. In some embodiments, the vaccine includes none of these four components.
9636410 Cationic oil-in-water emulsions  
This invention generally relates to cationic oil-in-water emulsions that contain high concentrations of cationic lipids and have a defined oil:lipid ratio. The cationic lipid can interact with the...
9636394 Process for producing influenza vaccine  
A process for producing a split influenza virus preparation or subunit influenza preparation comprising the steps of: (i) providing a whole virus preparation; (ii) splitting the whole virus...
US20170107263 MUTANT FRAGMENTS OF OSPA AND METHODS AND USES RELATING THERETO  
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use...
US20170106070 USES OF PARASITE MACROPHAGE MIGRATION INHIBITORY FACTORS  
This invention relates to compositions (e.g. vaccine compositions) which can be used to provide a subject with protective immunity against a parasite infection. The compositions comprise: (i) an...
9623100 Compositions and methods for preparing Staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions  
The present invention relates to immunogenic conjugates comprising S. aureus serotype 5 and 8 capsular polysaccharides conjugated to carrier proteins and methods for their preparation and use....
9623095 Vaccination in newborns and infants  
The present invention relates to vaccines comprising at least one mRNA encoding at least one antigen for use in the treatment of a disease in newborns and/or infants, preferably exhibiting an age...
US20170101446 MUTANT FRAGMENTS OF OSPA AND METHODS AND USES RELATING THERETO  
The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use...
US20170100477 Methods of Immunizing a Subject and Compositions Related Thereto  
This disclosure relates to methods of immunization comprising administering an effective amount of an immunogenic composition comprising an antigen or vaccine and an adjuvant disclosed herein to a...
US20170100472 COMBINATION VACCINES WITH SEROGROUP B MENINGOCOCCUS AND D/T/P  
Serogroup B meningococcus antigens can successfully be combined with diphtheria, tetanus and pertussis toxoids (“DTP”) to provide effective combination vaccines for protecting against multiple...
US20170100467 PCSK9 VACCINE  
The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of...
9616084 Mannose-containing solution for lyophilization, transfection and/or injection of nucleic acids  
The present invention is directed to (the use of) a solution containing at least one nucleic acid (sequence) and free mannose for lyophilization, transfection and/or injection, particularly of RNA...
US20170095549 INFLUENZA VIRUS REASSORTMENT  
New influenza donor strains for the production of reassortant influenza A viruses are provided.
US20170080084 OIL/SURFACTANT MIXTURES FOR SELF-EMULSIFICATION  
Oil-in-water emulsions with small droplet sizes can be formed without requiring either microfluidisation or heating to cause phase inversion, but rather by simple mixing of a pre-mixed composition...
US20170079918 VACCINATION COMPOSITION  
The present invention is directed to vaccination composition comprising a particle comprising a polymer matrix incorporating an adjuvant and/or an antigen, to method of making them and use....
9597389 Oil-in-water emulsion influenza vaccine  
The present invention provides an immunogenic influenza composition in a dose volume suitable for human use, comprising an influenza virus antigen or antigenic preparation thereof and an adjuvant...
9597326 Benzonapthyridine compositions and uses thereof  
The present invention generally relates to compositions comprising benzonapthyridine small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in...
US20170072053 METHODS FOR PREPARING SQUALENE  
An improved method for preparing squalene from a squalene-containing composition, said method comprising the steps of (a) a purification distillation carried out at a temperature T1 (b) a...
US20170065702 METHODS OF MODULATING AN IMMUNE RESPONSE  
The present invention relates to methods of modulating an immune response in a subject by using a binding protein (e.g., an antibody or an antigen-binding portion of an antibody) to mask or alter...
9579372 Meningococcal fHBP polypeptides  
fHBP is a protein in Neisseria meningitidis. Three families of fHBP are known. To increase the ability of a fHBP protein to elicit antibodies that are cross-reactive between the families, fHBP is...
US20170051047 Clostridium Difficile Antibodies  
Compositions and methods for the treatment or prevention of Clostridium difficile infection in a subject are provided. The compositions comprise antibodies to Clostridium difficile toxin A. The...
9574181 Influenza virus reassortment method  
Methods for producing reassortant viruses are provided wherein the transcription and/or translation of the hemagglutinin and/or neuraminidase genes are suppressed.
9572874 Composition comprising a complexed (M)RNA and a naked mRNA for providing or enhancing an immunostimulatory response in a mammal and uses thereof  
The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, comprising or consisting of at least one (m)RNA, complexed with a cationic or polycationic...
9572873 Method of inducing a T lymphocyte response using T-cell immunogens derived from anti-viral proteins  
Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject...
9566326 Adjuvanted influenza vaccines for pediatric use  
An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric...
9561269 Neisseria meningitidis compositions and methods thereof  
In one aspect, the invention relates to an isolated polypeptide comprising an amino acid sequence that is at least 95% identical to SEQ ID NO: 71. In another aspect, the invention relates to an...
US20170029847 ARTIFICIAL NUCLEIC ACID MOLECULES  
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3′-untranslated region element (3′-UTR) element comprising a nucleic acid...
US20170029526 ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF  
The present invention provides antibodies or the antigen-binding portion thereof, that bind to one or more carbohydrate antigens. Also disclosed herein are pharmaceutical compositions and methods...
US20170028060 COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS  
This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably...
US20170028059 VACCINE COMPOSITION COMPRISING COMPLEXED IMMUNOSTIMULATORY NUCLEIC ACIDS AND ANTIGENS PACKAGED WITH DISULFIDE-LINKED POLYETHYLENEGLYCOL/PEPTIDE CONJUGATES  
The present invention is directed to a composition or vaccine composition comprising a) an adjuvant component comprising or consisting of at least one immunostimulatory nucleic acid sequence,...
9555100 Herpes virus vaccine and methods of use  
Provided herein are, for example, immunogenic compositions and methods of using the same for the treatment or prevention of Herpesvirus infections.
US20170021006 IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATED CAPSULAR SACCHARIDE ANTIGENS, KITS COMPRISING THE SAME AND USES THEREOF  
The present invention relates to new immunogenic compositions comprising conjugated Streptococcus pneumoniae capsular saccharide antigens (glycoconjugates), kits comprising said immunogenic...
US20170014496 COMBINATION OF VACCINATION AND OX40 AGONISTS  
The present invention relates to a vaccine/agonist combination comprising an RNA vaccine comprising at least one RNA comprising at least one open reading frame (ORF) coding for at least one...
9545440 Methods for preparing squalene  
An improved method for preparing squalene from a squalene-containing composition, said method comprising the steps of (a) a purification distillation carried out at a temperature T1 (b) a...
US20170007689 METHODS AND COMPOSITIONS FOR NANOEMULSION VACCINE FORMULATIONS  
The present disclosure relates to nanoemulsion vaccine compositions and methods of making and using the same. The disclosed compositions and methods provide a means of treating, preventing, or...
9539212 Vaccination composition  
The present invention is directed to vaccination composition comprising a particle comprising a polymer matrix incorporating an adjuvant and/or an antigen, to method of making them and use....
9539210 Vaccine nanotechnology  
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides vaccine nanocarriers capable of stimulating an immune...
US20170000871 COMPOSITION FOR TREATING PROSTATE CANCER (PCa)  
The present invention relates to an active (immunostimulatory) composition comprising at least one RNA preferably an mRNA, encoding at least two (preferably different) antigens capable of...
9534019 Peptides with antimicrobial activity, drug compositions for the treatment and prophylaxis of animals, compositions for the treatment and prophylaxis of plants, uses of said peptides, and uses of Paenibacillus elgii ourofinensis extract  
The present invention provides methods of preparing extracts of material fermented with Paenibacillus sp., preferably Paenibacillus elgii ourofinensis. The extracts exhibit antimicrobial activity...
US20160375132 HOMOGENOUS SUSPENSION OF IMMUNOPOTENTIATING COMPOUNDS AND USES THEREOF  
The present invention generally relates to homogeneous suspensions of small molecule immune potentiators (SMIPs) that are capable of stimulating or modulating an immune response in a subject in...
US20160375118 MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION  
Provided is an immunogenic composition comprising 13 different polysaccharide-protein conjugates. Each of the conjugates comprises a capsular polysaccharide prepared from a different serotype...
« search again