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US20180201921 CRISPRs  
A composition for treating a lysogenic virus, including a vector encoding isolated nucleic acid encoding two or more gene editors chosen from gene editors that target viral DNA, gene editors that...
1000
WO/2018/136396A2 CRISPRS  
A composition for treating a lysogenic virus, including a vector encoding isolated nucleic acid encoding two or more gene editors chosen from gene editors that target viral DNA, gene editors that...
1000
WO/2018/136396A3 CRISPRS  
A composition for treating a lysogenic virus, including a vector encoding isolated nucleic acid encoding two or more gene editors chosen from gene editors that target viral DNA, gene editors that...
1000
WO/2018/130830A1 CRISPR RNA  
The present invention relates to an inducible CRISPR RNA comprising a spacer- blocking element, a cleavable loop element and a CRISPR sgRNA comprising a spacer element (guide sequence). The...
624
US20130288251 LACTOCOCCUS CRISPR-CAS SEQUENCES  
The present invention relates to a nucleic acid comprising a Lactococcus CRISPR repeat region and/or a Lactococcus CRISPR spacer region.
500
US20190071673 CRISPRs WITH IMPROVED SPECIFICITY  
A composition for treating a lysogenic virus, including a vector encoding isolated nucleic acid encoding two or more gene editors chosen from gene editors that target viral DNA, gene editors that...
500
US20110300538 BIFIDOBACTERIA CRISPR SEQUENCES  
The invention relates to CRISPR sequences found in bifidobacteria and their uses.
500
US20180340176 CRISPR-CAS SGRNA LIBRARY  
The present invention refers to a method for obtaining a CRISPR-Cas system sgRNA library and to the use of the library to select individual cell knock outs that survive under a selective pressure...
500
US20170204407 CRISPR/CAS TRANSCRIPTIONAL MODULATION  
Methods, compositions, and kits are provided for CRISPR/Cas mediated transcriptional modulation.
500
US20190085325 CONDITIONAL CRISPR SGRNA EXPRESSION  
An expression cassette for conditional expression of a single guide RNA (sgRNA) of a CRISPR/Cas9 system, the cassette includes a promoter, an sgRNA sequence, and a sequence flanked by at least a...
500
9790490 CRISPR enzymes and systems  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems...
500
9951341 Lactococcus CRISPR-Cas sequences  
The present invention relates to a nucleic acid comprising a Lactococcus CRISPR repeat region and/or a Lactococcus CRISPR spacer region.
500
US20180187190 NEW CRISPR ASSAYS  
The present invention relates to expression vectors harboring eukaryotic CRISPR sequences and their use in assays to study the intervention of eukaryotic CRISPR sequences with gene regulation and...
500
EP3169776A4 CRISPR/CAS TRANSCRIPTIONAL MODULATION   500
EP3219799A1 CONDITIONAL CRISPR SGRNA EXPRESSION  
The present invention relates to an expression cassette for conditional expression of a single guide RNA (sgRNA) of a CRISPR/Cas9 system, said cassette comprises a promoter, an sgRNA sequence, and...
500
EP2489275A1 CRISPR escape phage mutants  
The present invention provides methods and compositions related to modulating the resistance of a cell against a target nucleic acid or a transcription product thereof. In some preferred...
500
EP3169776A2 CRISPR/CAS TRANSCRIPTIONAL MODULATION   500
EP2489275B1 CRISPR escape phage mutants   500
EP2630156B1 LACTOCOCCUS CRISPR-CAS SEQUENCES   500
EP3374507A1 CRISPR-CAS SGRNA LIBRARY   500
EP3430139A1 CONDITIONAL CRISPR SGRNA EXPRESSION   500
EP2362915A2 BIFIDOBACTERIA CRISPR SEQUENCES   500
EP2362915B1 BIFIDOBACTERIA CRISPR SEQUENCES   500
EP3307888A1 NEW CRISPR ASSAYS   500
EP2630156A1 LACTOCOCCUS CRISPR-CAS SEQUENCES   500
WO/2016/200263A1 NEW CRISPR ASSAYS  
The present invention relates to expression vectors harboring eukaryotic CRISPR sequences and their use in assays to study the intervention of eukaryotic CRISPR sequences with gene regulation and...
500
WO/2019/089761A1 CRISPR PROTEIN INHIBITORS  
The embodiments disclosed herein utilize fluorescence polarization based preliminary screen to identify a putative set of Cas inhibitors from an initial set of candidate inhibitors. The primary...
500
WO/2019/009682A2 TARGET-SPECIFIC CRISPR MUTANT  
The present invention relates to an artificially manipulated CRISPR/Cas9 system. More particularly, the present invention relates to an artificially manipulated CRISPR enzyme having enhanced...
500
WO/2019/009682A3 TARGET-SPECIFIC CRISPR MUTANT  
The present invention relates to an artificially manipulated CRISPR/Cas9 system. More particularly, the present invention relates to an artificially manipulated CRISPR enzyme having enhanced...
500
WO/2010/054154A3 BIFIDOBACTERIA CRISPR SEQUENCES  
The invention relates to CRISPR sequences found in bifidobacteria and their uses.
500
WO/2012/054726A1 LACTOCOCCUS CRISPR-CAS SEQUENCES  
The present invention relates to a nucleic acid comprising a Lactococcus CRISPR repeat region and/or a Lactococcus CRISPR spacer region.
500
WO/2016/011080A3 CRISPR/CAS TRANSCRIPTIONAL MODULATION  
Methods, compositions, and kits are provided for CRISPR/Cas mediated transcriptional modulation.
500
WO/2016/011080A2 CRISPR/CAS TRANSCRIPTIONAL MODULATION  
Methods, compositions, and kits are provided for CRISPR/Cas mediated transcriptional modulation.
500
WO/2018/183403A1 CRISPR-ASSOCIATED (CAS) PROTEIN  
A new CRISPR-associated (Cas) protein, termed "CasM," is described, as well as polynucleotides encoding the same and methods of using CasM for site-specific genome engineering. CasM proteins are...
500
WO/2010/054154A2 BIFIDOBACTERIA CRISPR SEQUENCES  
The invention relates to CRISPR sequences found in bifidobacteria and their uses.
500
WO/2017/081097A1 CRISPR-CAS SGRNA LIBRARY  
The present invention refers to a method for obtaining a CRISPR-Cas system sgRNA library and to the use of the library to select individual cell knock outs that survive under a selective pressure...
500
WO/2017/158153A1 CONDITIONAL CRISPR SGRNA EXPRESSION  
The present invention relates to an expression cassette for conditional expression of a single guide RNA (sgRNA) of a CRISPR/Cas9 system, said cassette comprises a promoter, an sgRNA sequence, and...
500
WO/2019/094791A3 TARGETED CRISPR DELIVERY PLATFORMS  
The present invention is related to compositions and methods for gene therapy. Several approaches described herein utilize the Neisseria meningitidis Cas9 system that provides a hvperaccurate...
500
WO/2019/094791A2 TARGETED CRISPR DELIVERY PLATFORMS  
The present invention is related to compositions and methods for gene therapy. Several approaches described herein utilize the Neisseria meningitidis Cas9 system that provides a hvperaccurate...
500
JP2018532419A CRISPR-Cas sgRNA library  
In order that the present invention may choose the individual cell KO which survives under the method for obtaining a CRISPR-Cas system sgRNA library, and selection pressure, And/or, in order to...
500
JP2018519811A Ornamentation CRISPR RNA, ornamentation single CRISPR RNA, and its use  
This indication provides a compound containing modified oligonucleotide used for CRISPR. In a certain specific embodiment, such modified oligonucleotide provides the characteristic that crRNA has...
441
US20160362667 CRISPR-Cas Compositions and Methods  
Class 2 CRISPR-Cas nucleoprotein complexes are disclosed comprising a Class 2 CRISPR-Cas protein, a CRISPR-Cas associated polynucleotide lacking a spacer element (casPN), and a distinct spacer...
437
US20160237455 CRISPR-RELATED METHODS AND COMPOSITIONS  
Methods and compositions useful in targeting a payload to or editing a target nucleic acid utilizing CRISPR/Cas9 and guide RNA (gRNA) are disclosed herein
437
US20180230492 CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
437
US20180230493 CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
437
US20180274017 CRISPR EFFECTOR SYSTEM BASED DIAGNOSTICS  
The embodiments disclosed herein utilized RNA targeting effectors to provide a robust CRISPR-based diagnostic with attomolar sensitivity. Embodiments disclosed herein can detect broth DNA and RNA...
437
US20180320163 NOVEL CRISPR ENZYMES AND SYSTEMS  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems...
437
US20190194693 CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING  
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or...
437
US20180155716 NOVEL CRISPR ENZYMES AND SYSTEMS  
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems...
437
US20180195089 CRISPR Oligonucleotides and Gene Editing  
The present disclosure generally relates to compositions and methods for the genetic modification of cells. In particular, the disclosure relates to CRISPR reagents and the use of such reagents.
437
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