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7163801 |
Methods for determining the prognosis for cancer patients using tucan
The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the...
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5744310 |
Bax promoter sequence and screening assays for indentifying agents that regulate bax gene expression
The present invention provides a substantially purified bax promoter and a nucleic acid molecule containing a nucleotide sequence encoding a gene product operably linked to a bax promoter. The...
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6514761 |
Methods of using BCL-2 for the therapeutic treatment and prevention of diseases
The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the...
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6818750 |
Card proteins involved in cell death regulation
The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric...
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7812058 |
Methods and compounds useful to induce apoptosis in cancer cells
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
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7422862 |
Methods for identifying modulators of apoptosis
The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound...
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7655634 |
Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis
Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of...
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7741521 |
Inhibition of bid-induced cell-death using small organic molecules
Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.
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5702897 |
Interaction of proteins involved in a cell death pathway
The present invention provides methods for detecting an interaction among proteins involved in regulating cell death. The invention also provides a drug screening assay useful for identifying...
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8367644 |
Methods and compounds useful to induce apoptosis in cancer cells
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
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6130317 |
Bax inhibitor proteins
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
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5837838 |
Bax inhibitor proteins
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
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6265556 |
Nucleic acid encoding CD40 associated proteins
The present invention provides a mammalian CD40-associated protein (CAP), a nucleic acid molecule encoding the CAP and antibodies specific for the CAP. The invention further provides a...
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6696558 |
Bag proteins and nucleic acid molecules encoding them
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S....
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6545128 |
Anti-bax inhibitor protein antibodies
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
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7041783 |
Survivin-binding proteins, encoding nucleic acids, and methods of use
In accordance with the present invention, there are provided novel Survivin-binding-proteins (SBPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The...
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7208581 |
TRAF family proteins
In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors...
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7390656 |
Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
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6638734 |
Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
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7087386 |
Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
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5659024 |
Promotors that regulate the expression of genes involved in cell death
The present invention provides regulatory elements that are linked to genes involved in cell death. For example, the present invention provides a p53-RED, which is involved in p53-mediated...
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6994979 |
Conversion of apoptotic proteins
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
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8273705 |
Conversion of apoptotic proteins
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
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7192728 |
Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome...
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6228603 |
Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome...
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7176277 |
Conversion of apoptotic proteins
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
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7491700 |
Conversion of apoptotic proteins
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
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7615623 |
BAG proteins and nucleic acid molecules encoding them
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S....
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7588914 |
Bacterial Bcl-2 domain-containing polypeptides, encoding nucleic acid molecules, and related methods
The invention provides isolated Bcl-2 domain-containing polypeptides from Mycobacterial species, including M. tuberculosis, M. avium, M. bovis, M. leprae and M. smegmatis, and from Streptomyces...
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7704700 |
Methods for determining the prognosis for patients with a prostate neoplastic condition using inhibitor of apoptosis polypeptides
The invention provides a method of determining a prognosis for survival for a patient with a prostate neoplastic condition. The method consists of (a) measuring the level of XIAP in a neoplastic...
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7393666 |
Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis
Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of...
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7671183 |
PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use
The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and...
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7994282 |
Card proteins involved in cell death regulation
The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric...
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7910370 |
Methods of using BCL-2 for the therapeutic treatment and prevention of diseases
The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the...
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7951544 |
Method for determining the prognosis of cancer patients by measuring levels of bag expression
In accordance with the present invention, there are provided methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. Also provided are methods...
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6953691 |
Nucleic acid molecule encoding a PANG6 polypeptide
The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and...
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6965023 |
Death domain proteins
In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules...
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7196182 |
Card domain containing polypeptides, encoding nucleic acids, and methods of use
The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific...
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8008354 |
Death receptor sensitizing compounds and methods of use therefor
Methods of identifying death receptor sensitizing compounds and methods of using death receptor sensitizing compounds are provided.
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7521548 |
Apoptosis modulator Bcl-B and methods for making and using same
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human...
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7666607 |
TRAF family proteins
In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors...
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7982002 |
Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPS) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
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7638324 |
Bcl-G polypeptides, encoding nucleic acids and methods of use
The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors...
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7982023 |
Bag proteins and nucleic acid molecules encoding them
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S....
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8034901 |
Bcl-G polypeptides, encoding nucleic acids and methods of use
The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors...
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8071315 |
Detecting Bcl-B expression in cancer and uses thereof
Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer,...
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7927816 |
Methods for identifying modulators of apoptosis
The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound...
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7750134 |
Nucleic acids encoding microbial SUMO protease homologs
The invention provides isolated SUMO-specific protease-like (or “SSP”) domain-containing polypeptides from microorganisms, including bacteria, protozoans and yeast, including Escherichia, Sal...
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7846681 |
Apoptosis modulator BCL-B and methods for making and using same
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human...
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7927832 |
Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
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