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5744310 Bax promoter sequence and screening assays for indentifying agents that regulate bax gene expression  
The present invention provides a substantially purified bax promoter and a nucleic acid molecule containing a nucleotide sequence encoding a gene product operably linked to a bax promoter. The...
7163801 Methods for determining the prognosis for cancer patients using tucan  
The invention provides methods for determining a prognosis for survival for a cancer patient. One method involves (a) measuring a level of a TUCAN in a neoplastic cell-containing sample from the...
6696558 Bag proteins and nucleic acid molecules encoding them  
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S....
7741521 Inhibition of bid-induced cell-death using small organic molecules  
Various phenylamine derivatives are described as well as the use of compounds to inhibit BID protein for controlling apoptotic cascade.
6130317 Bax inhibitor proteins  
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
5837838 Bax inhibitor proteins  
The present invention provides substantially purified nucleic acid molecules encoding Bax inhibitor protein-1 (BI-1; SEQ ID NO: 1) or Bax inhibitor protein-2 (BI-2; SEQ ID NO: 4), nucleic acid...
8367644 Methods and compounds useful to induce apoptosis in cancer cells  
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
7422862 Methods for identifying modulators of apoptosis  
The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound...
7812058 Methods and compounds useful to induce apoptosis in cancer cells  
The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.
7655634 Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis  
Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of...
5702897 Interaction of proteins involved in a cell death pathway  
The present invention provides methods for detecting an interaction among proteins involved in regulating cell death. The invention also provides a drug screening assay useful for identifying...
7041783 Survivin-binding proteins, encoding nucleic acids, and methods of use  
In accordance with the present invention, there are provided novel Survivin-binding-proteins (SBPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The...
6638734 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto  
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
7390656 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto  
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
7087386 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto  
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
7951544 Method for determining the prognosis of cancer patients by measuring levels of bag expression  
In accordance with the present invention, there are provided methods for determining a prognosis of disease free or overall survival in a patient suffering from cancer. Also provided are methods...
7910370 Methods of using BCL-2 for the therapeutic treatment and prevention of diseases  
The invention provides a method of treating a disease or pathological condition resulting in apoptotic cell death. The method includes increasing the activity of Bcl-2 in cells affected by the...
7994282 Card proteins involved in cell death regulation  
The present invention provides NB-ARC and CARD-containing proteins (NACs), nucleic acid molecules encoding NACs and antibodies specific for at least one NAC. The invention further provides chimeric...
7208581 TRAF family proteins  
In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors...
8008354 Death receptor sensitizing compounds and methods of use therefor  
Methods of identifying death receptor sensitizing compounds and methods of using death receptor sensitizing compounds are provided.
7982023 Bag proteins and nucleic acid molecules encoding them  
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S....
8071315 Detecting Bcl-B expression in cancer and uses thereof  
Provided herein are compositions and methods of detecting Bcl-B expression in cancer cells to prognose, monitor, or select therapies for cancers such as breast cancer, prostate cancer, lung cancer,...
7927816 Methods for identifying modulators of apoptosis  
The invention provides a method of identifying an effective compound that modulates the binding of Humanin to Bax or Bid. The invention also provides a method of identifying an effective compound...
7671183 PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use  
The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and...
7750134 Nucleic acids encoding microbial SUMO protease homologs  
The invention provides isolated SUMO-specific protease-like (or “SSP”) domain-containing polypeptides from microorganisms, including bacteria, protozoans and yeast, including Escherichia, Sal...
8034901 Bcl-G polypeptides, encoding nucleic acids and methods of use  
The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors...
7704700 Methods for determining the prognosis for patients with a prostate neoplastic condition using inhibitor of apoptosis polypeptides  
The invention provides a method of determining a prognosis for survival for a patient with a prostate neoplastic condition. The method consists of (a) measuring the level of XIAP in a neoplastic...
7615623 BAG proteins and nucleic acid molecules encoding them  
The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S....
7393666 Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis  
Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of...
7588914 Bacterial Bcl-2 domain-containing polypeptides, encoding nucleic acid molecules, and related methods  
The invention provides isolated Bcl-2 domain-containing polypeptides from Mycobacterial species, including M. tuberculosis, M. avium, M. bovis, M. leprae and M. smegmatis, and from Streptomyces...
8273705 Conversion of apoptotic proteins  
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
7176277 Conversion of apoptotic proteins  
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
6994979 Conversion of apoptotic proteins  
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
7491700 Conversion of apoptotic proteins  
Compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and Bcl-XL are identified. These compounds have the ability to convert the activity of Bcl-2-family member proteins...
7927832 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto  
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
7638324 Bcl-G polypeptides, encoding nucleic acids and methods of use  
The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors...
7846681 Apoptosis modulator BCL-B and methods for making and using same  
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human...
7982002 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto  
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPS) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
8119410 Apoptosis modulator Bcl-B and methods for making and using same  
A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human...
7834149 Card-domain containing polypeptides, encoding nucleic acids, and methods of use  
The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are...
7666607 TRAF family proteins  
In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors...
7833750 Card-domain containing polypeptides, encoding nucleic acids, and methods of use  
The invention provides caspase recruitment domain (CARD)-containing polypeptides and functional fragments thereof, encoding nucleic acid molecules, and specific antibodies. Also provided are...
6965023 Death domain proteins  
In accordance with the present invention, there are provided novel Death Domain (DD), Death Effector Domain (DED) and NB-ARC domain proteins. The invention also provides nucleic acid molecules...
6953691 Nucleic acid molecule encoding a PANG6 polypeptide  
The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NB-ARC domains and...
6228603 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity  
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome...
7192728 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity  
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome...
7196182 Card domain containing polypeptides, encoding nucleic acids, and methods of use  
The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific...
7794961 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity  
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome...
8071327 Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity  
The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome...
7504253 Nucleic acid encoding proteins involved in protein degradation, products and methods related thereof  
In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPs) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and...
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