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US20090286875 |
ISOCYSTENE DERIVATIVES FOR THE TREATMENT OF PAIN
The present invention relates to compounds of formula (I): wherein R 1 , R 2 , R 4 and R 4a are as defined herein. The invention also relates to the use of compounds of formula (I) for the...
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US20090286804 |
METABOLITES OF 1-[6-(1-ETHYL-1-HYDROXY-PROPYL)-PYRIDIN-3-YL]-3-[2-(4-METHYL-PIPERAZIN-1-YL)-BENZYL]-PYRROLIDIN-2-ONE AS SERATONIN RECEPTOR ANTAGONISTS
Metabolites of 1-[6-(1-ethyl-1-hydroxy-propyl)-pyridin-3-yl]-3-[2-(4-methyl
-piperazin-1-yl)-benzyl]-pyrrolidin-2-one, and use of same. Metabolites of the present invention are as shown in Formula...
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7618996 |
Diaryl ether derivatives and uses thereof
Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such...
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7618972 |
Substituted triazole derivatives as oxytocin antagonists
The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions...
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7618797 |
Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the...
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7618633 |
Antibodies that bind CD40 and methods of treating cancer and enhancing immune responses
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7618626 |
Combination treatment for non-hematologic malignancies
The present invention relates to a therapeutic method for the treatment of non-hematologic malignancies comprising administering anti-IGF-1R antibodies, particularly human anti-IGF-1R antibodies,...
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US20090281148 |
TRICYCLIC COMPOUNDS, COMPOSITIONS AND METHODS
The present invention is directed to compounds of Formula I:
or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
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US20090281122 |
Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase, and Compositions and Treatments Using the Same
The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme...
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7615651 |
Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof
Compounds of Formula (I) that act as antagonists at the mu, kappa and/or delta opioid receptors and therefore useful in the treatment of diseases, conditions and/or disorders that benefit from such...
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US20090275577 |
IMIDAZOPYRIDINE AND IMIDAZOPYRIMIDINE DERIVATIVES AS ANTIBACTERIAL AGENTS
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable...
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US20090275536 |
Antibacterial Agents
Described herein are antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the...
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US20090275481 |
Anchored Transferrin Fusion Protein Libraries
Fusion proteins comprising a transferrin moiety, a stalk moiety, and cell wall linking member and peptide libraries thereof are disclosed. The present invention includes a method of screening...
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7612226 |
Amino acid derivatives
The present invention relates to a method of treating pain using a compound of formula
wherein R 1 , R 2 , R 3 and R 4 are as defined herein. The invention also relates to certain novel...
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7612084 |
Amine derivatives for the treatment of asthma and COPD
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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US20090270384 |
MORPHOLINE DOPAMINE AGONISTS
The present invention provides for compounds of formula (I), (Ia) and (Ib)
Wherein:
A is selected from C—X and N, B is selected from C—Y and N, R 1 is selected from H and (C 1 -C 6 )alkyl,...
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US20090270350 |
Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives
This invention is directed generally to substituted pyridinone and pyrimidinone compounds that generally inhibit p38 kinase, TNF, and/or cyclooxygeπase activity. Such substituted pyridinone and...
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7608604 |
Antiparasitic agents
The present invention relates to compounds of the formula (I)
or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein:
R 1 , R 2...
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US20090264425 |
CHEMICAL COMPOUNDS
This invention relates to biaryl ether derivatives of formula (I)
wherein R 1 , R 3 , R 4 , X, W, Y and m are defined in the description, and to compositions containing them and the uses of such...
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US20090264413 |
Compositions and Methods for Treating Female Sexual Dysfunction
This invention relates to methods, pharmaceutical compositions and kits useful in treating female sexual dysfunction and the use of an estrogen agonist/antagonist for the manufacture of a...
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US20090258362 |
RNA Bioassay
The present invention relates to methods for characterizing the pathological state of the kidney, methods of characterizing an agent, methods of evaluating the kidney protective and therapeutic...
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US20090257975 |
Solid and Semi-Solid Polymeric Ionic Conjugates
Aqueous solubility of drugs including insoluble or poorly soluble drugs such as ziprasidone is improved using a functional polymer to form an ionic conjugate with said drug.
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7601727 |
Pyrrolo[2,3-d]pyrimidine compounds
A compound of the formula
wherein R 1 , R 2 and R 3 are as defined above, which are inhibitors of the enzyme protein kinases such as Janus Kinase 3 and as such are useful therapy as...
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US20090253740 |
SUBSTITUTED N-BICYCLICALKYL BICYCLICCARBOXYAMIDE COMPOUNDS
This invention provides a compound of the formula (I): And their use for the treatment of disease conditions caused by overactivation of the VR1 receptor such as pain, or the like in mammal. This...
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US20090253739 |
Amine Derivatives
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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US20090253674 |
Substituted Triazole Derivatives As Oxytocin Antagonists
The present invention relates to substituted triazoles of formula (I), uses thereof, processes for the preparation thereof and compositions containing said compounds. These inhibitors have utility...
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US20090252744 |
Methods for Treating Bone Cancer Pain by Administering A Nerve Growth Factor Antagonist antibody
The invention features methods and compositions for preventing or treating bone cancer pain including cancer pain associated with bone metastasis by administering an antagonist of nerve growth...
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7598393 |
Sulfonyl benzimidazole derivatives
This invention relates to compounds of the formula (I):
or a pharmaceutically acceptable salt thereof, wherein A, B, R 1 , R 2 and R 3 are each as described herein, and compositions...
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7598231 |
Tricyclic compound, compositions, and methods
The present invention is directed to compounds of Formula I:
or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the...
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US20090247743 |
PREPARATION OF BETA-AMINO ACIDS HAVING AFFINITY FOR THE ALPHA-2-DELTA PROTEIN
Disclosed are materials and methods for preparing optically active β-amino acids of Formula 1,
which bind to the alpha-2-delta (α2δ) subunit of a calcium channel.
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US20090247570 |
PHARMACEUTICALS
The present invention relates to the use of a CCR5 antagonist in an HIV infected patient to enhance their immune reconstitution and so treat to HIV related opportunistic conditions resulting from...
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US20090247539 |
Novel Pharmaceuticals
This invention relates to compounds of formula (I)
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US20090247528 |
METHOD OF TREATING ATTENTION DEFICIT DISORDER
Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of...
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7595329 |
Benzimidazolone carboxylic acid derivatives
This invention relates to compounds of the formula (I):
wherein R 1 , R 2 , R 3 , A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions...
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7595325 |
Substituted pyrrolo[2,3-d]pyrimidine derivatives useful in cancer treatment
The invention relates to compounds of the formula 1
or a pharmaceutically acceptable salt, prodrug, solvate or hydrate thereof, wherein L, R 1 , R 2 , R 3 and R 4 are as defined herein. The...
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US20090239899 |
Triazolopyridinylsulfanyl Derivatives As P38 Map Kinase Inhibitors
A compound of formula (I), or a pharmaceutical acceptable salt and/or solvate (including hydrate) thereof;
and the use of a compound of formula (I) in the treatment of a TNF-mediated disease,...
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US20090239883 |
Treatment of Pulmonary Hypertension
This invention relates to the use of certain cyclic guanosine 3′,5′-monophosphate phosphodiesterase type five (cGMP PDE5) inhibitors, including in particular the compound sildenafil, for the...
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US20090239795 |
EXENDIN FUSION PROTEINS
The invention provides fusion proteins comprising an exendin-4 fused to a transferrin (Tf) via a polypeptide linker, as well as corresponding nucleic acid molecules, vectors, host cells, and...
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7592362 |
Substituted imidazoles
This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such...
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US20090233813 |
Condensed Heterocyclic Pyrazole Derivatives as Kinase Inhibitors
Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a...
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US20090232848 |
METHODS FOR CULTIVATING LAWSONIA INTRACELLULARIS
This invention relates to methods for cultivating Lawsonia intracellularis. In particular, the present invention provides improved methods for cultivating Lawsonia intracellularis by employing...
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7589109 |
Oxyindole derivatives
This invention relates to compounds of the formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
A, R 1 , R 2 , R 3 , R 4 and R 5 are each as described herein or a...
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US20090227680 |
Amino Acid Derivatives
The present invention relates to a method of treating pain using a compound of formula (I), wherein Ar, R 1 , R 3 and R 3a are as defined herein. The invention also relates to certain novel...
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US20090227641 |
CYCLOALKYLAMINO ACID DERIVATIVES
The invention relates to compounds of formula I
and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof. This invention also relates to a method of using such compounds...
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US20090227634 |
Pyrazole Derivatives as 5-LO-Inhibitors
The invention relates to compounds of formula (I)
processes for their preparation, their use as 5-lipoxygenase inhibitors and pharmaceutical compositions containing the same.
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US20090227562 |
Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor
The present invention relates to a combination of a selective noradrenaline reuptake inhibitor (NRI) and a phospho-diesterase type 5 (PDEV) inhibitor. Such a combination is particularly useful in...
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US20090226510 |
PHARMACEUTICAL COMPOSITIONS OF ATORVASTATIN
A unit dosage form comprising atorvastatin or a pharmaceutically acceptable salt thereof, prepared without a granulation step, wherein the measured atorvastatin potency of said dosage form shows a...
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US20090226486 |
N protein mutants of porcine reproductive and respiratory syndrome virus
The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified...
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US20090226484 |
Immunogenic LHRH compositions and methods relating thereto
The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino...
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7585869 |
Substituted heterocylces for the treatment of abnormal cell growth
The invention relates to compounds of formula 1
and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 3 , R 4 , R 11 , N, Z, A, m and p are as defined herein....
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