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7659394 |
Substituted morpholine compounds for the treatment of central nervous system disorders
This invention relates to compounds of the formulae I
wherein R 1 -R 8 , A, X, and Z are defined as in the specification, pharmaceutical compositions containing them and their use in the...
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7659305 |
Therapeutic proline derivatives
The compounds of formula (I) or a pharmaceutically acceptable salt, solvate or pro-drug thereof, are proline derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial...
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US20100029710 |
COMPOUNDS HAVING BOTH ANGIOTENSIN II RECEPTOR ANTAGONISM AND PPARy ACTIVATING ACTIVITIES
Compounds of following formula (I) are provided that have both angiotensin II receptor antagonist activity and PPARy agonist activity. Also provided are pharmaceutical compositions comprising the...
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US20100028915 |
CIRCULATING TUMOR CELL ASSAY
Methods for the detection, enumeration and analysis of circulating tumor cells expressing insulin-like growth factor-1 receptors (IGF-1R) are disclosed. These methods are useful for cancer...
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US20100028379 |
METHODS OF VACCINE ADMINISTRATION
This invention relates to a method of treating a dog for canine diseases comprising administering to the dog therapeutically effective amounts of a vaccine, wherein the vaccine comprises viral...
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7655692 |
Process for forming amorphous atorvastatin
Forming amorphous atorvastatin comprises the steps of dissolving atorvastatin in a hydroxylic solvent, followed by rapidly evaporating the solvent. In another aspect, a composition comprises...
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7655656 |
Hair growth promoting agents
The present invention is directed to crystalline forms of 6-[[(3S,4R)-3,4-dihydro-3-hydroxy-6-[(3-hydroxypheny)sulfony
l]-2,2,3-trimethyl-2H-1-benzopyran-4-yl]oxy]-2-methyl-3(2H)-
pyridazinone,...
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7655232 |
Anti-NGF antibodies and methods using same
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or...
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7655231 |
Methods for treating pain by administering a nerve growth factor antagonist and an NSAID
The present invention features methods for treating or preventing pain comprising administering an amount of a nerve growth factor antagonist (such as an anti-NGF antibody) and an amount of an...
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US20100021966 |
Method for the Preparation of Growth Hormone and Antagonist Thereof Having Lower Levels of Isoform Impurities Thereof
The present invention is directed generally to recombinant methods for making a desired polypeptide. These method(s) yield a polypeptide product containing reduced levels of isoform impurities...
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7649004 |
Pyridine derivatives
The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation...
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7649003 |
Substituted triazole derivatives as oxytocin antagonists
The present invention relates to a class of substituted 1,2,4-triazoles of formula (1) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions...
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7649002 |
(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
The present invention relates to a class of melanocortin MCR4 agonists of general formula (I)
wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined herein and especially to selective MCR4...
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US20100010093 |
ANTIPARASITIC AGENTS
The present invention relates to compounds of the formula (I)
or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein:
R 1 ,...
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7645786 |
Substituted arylpyrazoles
This invention relates to a range of 1-aryl-4-cyclopropylpyrazoles in which the cyclopropyl ring is substituted at the angular position, and pharmaceutically acceptable salts and solvates thereof,...
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7645781 |
N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
The present invention provides antibacterial agents having the formulae I, II, and III described herein.
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US20100004259 |
Tartrate Salt of (7S)-7-[(5-Fluoro-2-Methyl-Benzyl)oxy]-2-[(2R)-2-Methylpiperazin-1-YL]-6,7-Dihydro-5H-Cyclopenta[B]Pyridine
The present invention provides a tartrate salt of Formula (I), Formula I is also known as...
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US20100003331 |
SUSTAINED RELEASE DOSAGE FORMS OF ZIPRASIDONE
A sustained release solid oral dosage form for treatment of a psychotic disorder, for example schizophrenia, in a mammal is provided, which oral dosage form comprises ziprasidone in an amount...
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US20100002225 |
Methods and Apparatus for Maintaining Effective Operation of Apparatus for Candling Avian Eggs
Egg candling methods and apparatus are provided wherein the optical path between a light source and light detector is monitored for obscuring debris and/or malfunctions. A method of candling eggs...
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7642350 |
Purine derivatives
This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use. The present invention provides compounds of formula (I)
...
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US20090324641 |
NOVEL ADJUVANT COMPOSITIONS
This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant...
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RE41065 |
Alkynl and azido-substituted 4-anilinoquinazolines
The invention relates to compounds of the formula
and to pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , n and m are as defined herein. The compounds of formula I...
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7638537 |
Pyrazole compounds as transforming growth factor (TGF) inhibitors
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The...
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US20090318497 |
SUBSTITUTED PYRIDYLMETHYL BICYCLICCARBOXYAMIDE COMPOUNDS
This invention provides a compound of the formula (I): wherein A 1 is N and A 2 is CR 7 , or A 1 is CR 7 and A 2 is N; Y 1 , Y 2 and Y 3 are each independently CH or N, Y 4 and Y 5 are...
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US20090318451 |
MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN
The present invention relates to use of a compound of formula (I), (Ia), or (Ib):
wherein A, B, Z, R 1 and R 2 have the meanings given in the specification, as a medicament for the treatment...
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US20090318440 |
CARBONYLAMINO PYRROLOPYRAZOLES, POTENT KINASE INHIBITORS
Carbonylamino Pyrrolopyrazole compounds of formula I, compositions including these compounds and methods of their use are provided. Preferred compounds of formula I have activity as protein kinase...
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US20090318431 |
BENZOXAZINONE AND BENZOXAZEPINONE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS
The present invention provides a compound of formula (I) wherein X is a structure of the following formula (i), (ii) (iii), or iv G is O, or S; U is —(CR 3 R 4 ) n —; W is CH 2 NHC(=G)R 1 , CH...
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US20090318297 |
Antibody Ultrahumanization by Predicted Mature CDR Blasting and Cohort Library Generation and Screening
Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal...
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US20090314691 |
METHOD AND APPARATUS FOR MONITORING THE PERFORMANCE OF AUTOMATED EGG REMOVAL
Methods and apparatus are provided that automatically determine whether or not eggs designated for removal from an egg carrier have been removed by an egg removal apparatus. Light is emitted along...
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7635702 |
Imidazole compounds as transforming growth factor (TGF) inhibitors
Novel imidazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The...
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US20090312371 |
SUBSTITUTED ARYLPYRAZOLES
This invention relates to a combination product comprising a range of 1-aryl-4-cyclopropylpyrazoles in which there is at least one fluorine attached to the cyclopropyl ring, and one o more further...
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US20090312326 |
SUBSTITUTED IMIDAZOLES
This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such...
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US20090312280 |
COMBINATION THERAPY OF (2R,Z)-2-AMINO-2-CYCLOHEXYL-N-(5-(1-METHYL-1H-PYRAZOL-4-YL)-1-OXO-2,6-DIHYDRO-1H-[1,2]DIAZEPINO[4,5,6-CD]INDOL-8-YL)ACETAMIDE
The present invention relates to novel combination therapies of (2R,Z)-2-amino-2-cyclohexyl-N-(5-(1-methyl-1H-pyrazol-4-yl)-
1-oxo-2,6-dihydro -1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide...
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US20090311254 |
CD40 ANTIBODY FORMULATION AND METHODS
The present invention provides a method of treating tumor in a patient comprising administering to said patient a CD40 agonist antibody according to an intermittent dosing schedule. The present...
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7632854 |
Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
Compounds which are indazole derivatives and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them, as well as combinatorial libraries of indazole...
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US20090306388 |
METHOD FOR SUBSTITUTED IH-IMIDAZO[4,5-C] PYRIDINES
Methods for preparing compounds of the Formulas IV and I are disclosed. The methods include combining a compound of the Formula II: with a benzylamine of the Formula III: in the presence of an acid...
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US20090306384 |
Process for the Production of Benzopyran-2-ol Derivatives
The invention provides a process for producing a compound of formula (I),
wherein Y is selected from the group consisting of CH 3 , CH 2 OH, CH 2 CH 2 OH, CH 2 Br and Br; comprising the steps...
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US20090306108 |
SUBSTITUTED PYRIMIDINONES
Disclosed are compounds Formula I
and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 4 , and R 5 are defined herein. These compounds are useful for treating diseases and...
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7629363 |
Diaryl substituted pyridinones
Disclosed are compounds Formula I
and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 /R 4 , and R 5 are defined herein. These compounds are useful for treating...
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7629358 |
Compounds useful for the treatment of diseases
The invention relates to compounds of formula (1)
and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives....
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US20090299093 |
Preparation of Gamma-Amino Acids Having Affinity for The Alpha-2-Delta Protein
Disclosed are materials and methods for preparing optically active γ-amino acids of Formula 1,
which bind to the alpha-2-delta (α2δ) subunit of a calcium channel.
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US20090298821 |
HYDROXY AND ALKOXY SUBSTITUTED IH-IMIDAZONAPHTHYRIDINES AND METHODS
1H-Imidazo[4,5-c]naphthyridin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of...
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US20090298811 |
BENZIMIDAZOLONE DERIVATIVES
This invention relates to compounds and methods for the treatment of a condition mediated by CB1 receptor activity in a mammalian subject including a human, which comprises administering to a...
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7626012 |
Nucleic acid molecules which encode antibodies that bind CD40
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also...
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7625507 |
Extrusion process for forming chemically stable drug multiparticulates
Reduced levels of drug degradation in drug-containing multiparticulates are obtained by an extrusion/melt-congeal process.
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US20090291953 |
PHARMACEUTICAL SALTS OF REBOXETINE
The present invention relates to novel crystalline, water-soluable salts of the 2S,3S enantiomer of reboxetine, which are the fumarate and succinate salts thereof, to a process for their...
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US20090291098 |
Immunogenic LHRH compositions and methods relating thereto
The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino...
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7622605 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme...
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7622589 |
Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists
This invention provides a compound of the formula (I):
wherein, variables A, B, D, E, and R 1 to R 11 are as defined in the specification.
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7622500 |
Antiparasitic agents
The present invention relates to compounds of the formula (I)
and pharmaceutically acceptable salts thereof, compositions containing such compounds and the uses of such compounds as...
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