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US20090286779 |
PYRAZOLOPYRIMIDINES AS LIPID KINASE INHIBITORS
The invention relates to novel—at least 3,5-disubstituted-pyrazolo[1,5-a]pyrimidines of the formula I,
wherein the symbols R 1 to R 4 are as defined in the specification, tautomers thereof...
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US20090286312 |
Methods and Compositions for Treating Allergic Diseases
Disclosed in the present invention are antibodies that specifically recognize and antagonize human TSLP receptor, and methods of employing these antibodies to treat or ameliorate diseases or...
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US20090285854 |
FROZEN STOCKPILING OF INFLUENZA VACCINES
A problem with stockpiling influenza vaccines is their short shelf life. Storage volume is another problem. The invention prepares and stockpiles bulk vaccine, and the bulk is stored under frozen...
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US20090285622 |
APPLICATOR UNIT
An applicator unit for use in applying a substance to a surface, the applicator unit comprising: a body unit to which a container is movably disposed; an outlet unit which includes an applicator...
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7618642 |
Expression cassettes encoding modified human immunodeficiency virus type 1 subtype C envelope glycoproteins
The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immunization, generation of packaging cell...
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7618636 |
Antigenic meningococcal peptides
WO99/36544 discloses a large number of proteins from Neisseria Meningitidis . The present invention relates to fragments of those proteins which comprise at least one antigenic determinant....
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US20090281159 |
USE OF HDAC INHIBITORS FOR THE TREATMENT OF LYMPHOMAS
The present invention relates to the use of an HDAC inhibitor, especially an HDAC inhibitor of formula (I):
wherein the radicals and symbols have the meanings as defined in the specification,...
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US20090281126 |
Organic Compounds
A compound of formula (I) and their preparation and use as pharmaceuticals
wherein R 1 , R 2 and R 3 are as defined herein.
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US20090281113 |
METHOD OF OPTIMIZING THE TREATMENT OF PHILADELPHIA-POSITIVE LEUKEMIA WITH ABL TYROSINE KINASE INHIBITORS
The present invention provides a method of treating Philadelphia positive (Ph+) leukemia, such as Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) or chronic myeloid leukemia...
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US20090281090 |
BIOMARKERS FOR THE PREDICTION OF RESPONSIVENESS TO CLOZAPINE TREATMENT
This invention provides methods to predict the likelihood of suicidal or self-destructive behaviour in a patient during treatment. The method employs the detection of a VNTR polymorphism in the...
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US20090280136 |
IMMUNIZATION OF FISH WITH PLANT-EXPRESSED RECOMBINANT PROTEINS
Plants are produced that express an amino acid sequence that, when administered to a fish, produce an antigenic or immune response in the fish. The amino acid sequence in one embodiment is an...
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US20090280129 |
HIGH CONCENTRATION ANTIBODY AND PROTEIN FORMULATIONS
The present application relates to highly concentrated antibody and protein formulations with reduced viscosity that are stable, relatively isotonic and are of low turbidity. The formulations are...
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7615635 |
N-formyl hydroxylamines
Novel N-formyl hydroxylamine compounds and their derivatives are disclosed. These N-formyl hydroxylamine compounds inhibit peptidyl deformylase (PDF), an enzyme present in prokaryotes. The...
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7615609 |
Preparation of somatostatin peptides
Provided is a process for preparing cyclic somatostatin analogues and the linear intermediates used in this process.
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7615562 |
2-aminopyrimidine derivatives and their medical use
A compound of formula I or a pharmaceutically acceptable salt, ester or prodrug thereof wherein the variables have the meanings as defined in the specification. Further disclosed are a method of...
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7615523 |
Lens care product containing dexpanthenol
The present invention relates to contact lens care product comprising dexpanthenol. The invention similarly relates to the usage of a contact lens care compositions of this kind for cleaning and...
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US20090275606 |
Heterocyclic Compounds as MEK Inhibitors
The present invention relates to compounds of formula I
and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative...
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US20090275593 |
3 Substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidines as Kinase Inhibitors
The invention relates to 3-substituted N-(aryl- or heteroaryl)-pyrazolo[1,5-a]pyrimidine compounds, their use as kinase inhibitors, new pharmaceutical formulations comprising said compounds, said...
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US20090275560 |
ORGANIC COMPOUNDS
The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those...
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7612238 |
Amino-propanol derivatives
Compounds of formula I
wherein R 1 , R 2 , R 3 , R 4 and R 5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
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7612192 |
Neisseria genomic sequences and methods of their use
The invention provides methods of obtaining immunogenic proteins from genomic sequences including Neisseria , including the amino acid sequences and the corresponding nucleotide sequences, as well...
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7612055 |
Macrocyclic lactams and pharmaceutical use thereof
The present invention relates to novel macrocyclic compounds of the formula
wherein R 1 , R 2 , R 3 , U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms...
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7612054 |
Dibenzo[b,f]oxepine-10-carboxamides and pharmaceutical uses thereof
The present invention pertains to novel dibenzo[b,f]oxepine-10-carboxamides compound to a process for the preparation of such compounds of formula I, their use as a pharmaceuticals, especially in...
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7612052 |
Combinations comprising epothilones and pharmaceutical uses thereof
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I
wherein A represents O...
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7611708 |
Methods of therapy for B-cell malignancies using antagonist anti-CD40 antibodies
Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment...
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US20090270417 |
Organic Compounds
Novel 3,4-di-, 3,3,4-di-, 3,4,4,-tri- and 3,3,4,4-tetra-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially...
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7608723 |
Indole and benzimidazole derivatives
The present invention relates to new indole and benzimidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with...
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7608276 |
Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic...
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US20090264649 |
DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity...
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US20090264406 |
3-METHYL-IMIDAZO[1,2-B]PYRIDAZINE DERIVATIVES
The invention relates to compounds of formula (I) and salts thereof
wherein the substituents are as defined in the specification, the application of a compound of formula (I) in a process for...
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US20090260623 |
Aeorosolization apparatus with air inlet shield
An aerosolization apparatus comprises a housing defining a chamber having a plurality of air inlets. The chamber contains an aersolizable pharmaceutical formulation or is sized to receive a...
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7605267 |
Process for the preparation of 5-(halocetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones
The invention relates to a process for preparing 5-(α-haloacetyl)-8-substituted oxy-(1H)-quinolin-2-ones. The process involves (i) reacting (a) 8-hydroxy-(1H)-quinolin-2-one with an acylating...
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7605246 |
Genes differentially expressed in breast cancer
A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of...
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7604810 |
Conserved Neisserial antigens
To ensure maximum cross-strain recognition and reactivity, regions of proteins that are conserved between different Neisserial species, serogroups and strains can be used. The invention provides...
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7604802 |
Method of obtaining cellular immune responses from proteins
A method for producing a cellular immune response in a vertebrate subject comprising administering to the vertebrate subject a vaccine composition comprising a protein particle antigen and a...
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US20090258882 |
2,4-Substituted Quinazolines as Lipid Kinase Inhibitors
The invention relates to compounds of the formula I,
which are appropriate for the treatment of kinase, e.g. PI3K-related, diseases, such as proliferative diseases, inflammatory diseases,...
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US20090258874 |
PYRAZOLO-HETEROARYL COMPOUNDS
A compound of formula I
wherein the groups R1-R4, X and Y are as defined in the specification, useful to treat TNF-Alpha and IL-1 mediated diseases.
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7600511 |
Apparatus and methods for delivery of medicament to a respiratory system
Apparatus and methods are provided for delivery of a medicament to a respiratory system. A reservoir is provided for a liquid medicament with the reservoir having a liquid medicament inlet port and...
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US20090252738 |
Compositions and methods of therapy for cancers characterized by expression of the tumor-associated antigen mn/ca ix
Compositions and methods useful in inhibiting proliferation of CA IX+preneoplastic or neoplastic cells in a mammal are provided. The compositions are antagonist anti-CA IX antibodies and other...
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US20090249898 |
Systems and methods for non-destructive mass sensing
The invention provides systems and methods for measuring the mass of a substance. In one method, energy is applied to a substance and a response resulting from the application of energy as...
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7598268 |
Quinolinone derivatives
Organic compounds having the formula I are provided where the variables have the values described herein.
Pharmaceutical formulations include the organic compounds or pharmaceutically...
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7597908 |
Use of microparticles with adsorbed antigen to stimulate immune responses
The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.
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US20090249519 |
IMMUNIZATION OF FISH WITH PLANT-EXPRESSED RECOMBINANT PROTEINS
Plants are produced that express an amino acid sequence that, when administered to a fish, produce an antigenic or immune response in the fish. The amino acid sequence in one embodiment is an...
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US20090247547 |
HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B
The present teachings relate to compounds of Formula I:
and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R 1 , R 2 , R 3 , Y, Z, and are as defined...
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US20090246215 |
Amyloid beta1-6 antigen arrays
The present invention is related to the fields of molecular biology, virology, immunology and medicine. The invention provides a composition comprising an ordered and repetitive antigen or...
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US20090246208 |
METHODS FOR PREVENTING AND TREATING CANCER METASTASIS AND BONE LOSS ASSOCIATED WITH CANCER METASTASIS
Methods for preventing and treating osteolysis, cancer metastasis and bone loss associated with cancer metastasis by administering an M-CSF-antagonist in combination with a therapeutic agent to a...
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7595390 |
Industrially scalable nucleoside synthesis
An industrially scalable two-step process for preparing a β-L-2′-deoxy-nucleoside that results in a predominance of the β- over the α-anomeric form of the compound is described. An optional...
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7595040 |
Deamidated interferon-β
Interferon-β protein analogs in which the asparagine at position 25, numbered in accordance with native interferon-β, is deamidated exhibit a biological activity of native human interferon-β at...
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US20090240045 |
Organic Compounds
A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, and their preparation and use as pharmaceuticals
wherein R 1 , R 2 , R 3 , R 4 and W are as defined herein.
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US20090239908 |
METHODS OF TREATING PSYCHOSIS AND SCHIZOPHRENIA BASED ON POLYMORPHISMS IN THE CNTF GENE
This invention relates to the use of the association between the 103 G>A polymorphism in the CNTF gene to determine antipsychotic treatment strategies in patients with psychotic disorders.
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