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7659311 |
Disodium salts, monohydrates, and ethanol solvates for delivering active agents
The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore,...
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7659293 |
-Amino-N-hydroxy-acetamide derivatives
The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula I,
wherein R is di-lower alkyl amino, 1,2,3-triazol-1-yl, 1,2,3-triazol-2-yl or 1,2,4-triazol-4-yl, m represents an...
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7659248 |
Stabilized compositions comprising tissue factor pathway inhibitor protein or tissue factor pathway inhibitor variant proteins
Stabilized aqueous compositions of tissue factor pathway inhibitor (TFPI) or TFPI variants comprise a solubilizing agent, an antioxidant, and a buffer. The combination of a solubilizing agent and...
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US20100029718 |
ORGANIC COMPOUNDS
The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase...
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US20100029605 |
COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated...
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US20100028335 |
Compositions and Methods to Treat Bone Related Disorders
The present invention relates to the use of modulators of the sclerostin: sclerostin-binding-partner interaction for the treatment, amelioration, and diagnosis of sclerostin-related disorders,...
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7657385 |
Structure-based hepatitis C virus drug design
The extracellular loop of CD81 is a cellular receptor for the E2 protein of hepatitis C virus. A CD81 crystal structure has been elucidated and is provided for use in the structure-based design of...
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7655686 |
Certain substituted spirocyclic lactams and use thereof as pharmaceuticals
The present invention relates to novel 2-(6-oxo-1,7-diaza-spiro[4.4]non-7-yl)-propionamides of the formula
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , m and p are as defined in the...
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7655669 |
Pyrimidineamide derivatives and the use thereof
The invention relates to novel substituted N-(3-benzoylaminophenyl)-4-pyridyl-2-pyrimidinamine derivatives, processes for the preparation thereof, pharmaceutical compositions containing same, the...
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7655666 |
Substituted 1H-quinazoline-2,4-diones useful as AMPA receptor ligands
The present invention relates to 1H-Quinazoline-2,4-diones of formula (I)
wherein R 1 and R 2 are as defined in the specification, their preparation, their use as pharmaceuticals, and...
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7655245 |
Neisserial antigens
The invention provides proteins from Neisseria meningitidis (strains A & B) and from Neisseria gonorrhoeae , including amino acid sequences, the corresponding nucleotide sequences, expression...
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US20100022500 |
Macrocyclic Lactams and Pharmaceutical Use Thereof
The present invention relates to novel macrocyclic compounds of the formula
wherein R 1 , R 2 , R 3 , U, V, W, X, Y, Z and n are as defined in the specification, the number of ring atoms...
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US20100021548 |
USE OF MICROPARTICLES WITH ADSORBED ANTIGEN TO STIMULATE IMMUNE RESPONSES
The use of poly(lactide) or poly(lactide-co-glycolide) microparticles with adsorbed antigen is disclosed. The microparticles are useful for enhancing CTL responses to a selected antigen.
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7652756 |
Method and apparatus for centering an ophthalmic lens
An ophthalmic lens , e.g. a contact lens, is centered in a concave trough ( 10 ) of an inspection cell ( 1 ) which is filled with liquid (W). The inspection cell ( 10 ) has a channel ( 11 ) which...
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7652061 |
N-acyl nitrogen heterocycles as ligands of peroxisome proliferator-activated receptors
Compounds of the formula
provide pharmacological agents which bind to Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are useful for the...
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7652044 |
P-38 inhibitors
Provided are 5-membered heterocycle-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the...
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7652022 |
Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
The invention relates to the use of diaryl urea derivatives in the treatment of protein kinase dependent diseases or for the manufacture of pharmaceutical compositions for use in the treatment of...
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US20100015168 |
IMMUNOGENIC COMPOSITIONS FOR STREPTOCOCCUS AGALACTIAE
The invention relates to immunogenic polypeptides derived from epitopes in a Streptococcus agalactiae (“GBS”) protein GBS 80 and their use as prophylactic, diagnostic and therapeutic...
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US20100015151 |
POLYPEPTIDES FROM NEISSERIA MENINGITIDIS
Various specific meningococcal proteins are disclosed. The invention provides related polypeptides, nucleic acids, antibodies and methods. These can all be used in medicine for treating or...
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D608448 |
Lens power fine tuning device
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7649023 |
Biodegradable block copolymeric compositions for drug delivery
An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling...
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7648989 |
Indolylmaleimide derivatives as PKC inhibitors
This invention relates to PKC inhibitors which are able to selectively inhibit e.g. the and optionally 0, isoforms of PKC, and their use in particular in transplantation.
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US20100010199 |
MAKING INFLUENZA VIRUS VACCINES WITHOUT USING EGGS
Currently, the steps performed prior to release of influenza strains to vaccine manufacturers involve passaging influenza virus through eggs. The invention aims to provide procedures useful in...
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US20100009978 |
Benzoxazoles and Oxazolopyridines Being Useful as Janus Kinases Inhibitors
The invention relates to 2,7-disubstituted benzoxazole and 2,4-disubstituted oxazolo[5,4-c]pyridine compounds of the formula I given below, as well as salts thereof, processes for the preparation...
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US20100009392 |
USE OF MELANOMA INHIBITORY ACTIVITY (MIA) PROTEIN AS AN EARLY INDICATOR FOR THERAPEUTIC RESPONSE IN MELANOMA
The present invention provides a method for determining a response of a mammalian subject having melanoma tumor cells to treatment with a melanoma inhibitory agent. In one aspect, the method...
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US20100008923 |
Organic Compounds
The invention relates to pharmaceutical compositions containing inhibitors of histone deacetylase and B vitamins and methods of use thereof, in the treatment of HDAC dependent diseases and for the...
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7645760 |
1-(4-Benzyl-piperazin-1-yl)-3-phenyl-propenone derivatives
A compound of formula (I), or a pharmaceutically acceptable salt or ester thereof, wherein the symbols have meaning as defined, which are antagonists of CCR-1 and which find use pharmaceutically...
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US20100004303 |
TREATMENT OF ENDOCRINE DYSFUNCTION USING IRON CHELATORS
The invention relates to the use of an iron chelator for the treatment or prevention of pathologies due to iron loading, e.g. related to a dysfunction, in particular a reduction or inhibition, of...
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US20100004253 |
BIOMARKERS OF TARGET MODULATION, EFFICACY, DIAGNOSIS AND/OR PROGNOSIS FOR RAF INHIBITORS
Methods of utilizing biomarkers to identify patients for treatment or to monitor response to treatment are taught herein. Alterations in levels of gene expression of the biomarkers, particularly in...
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US20100004243 |
PHARMACEUTICAL COMPOUNDS
The invention provides a cyclin dependent kinase (e.g. cdk-4 kinase) inhibitor of the formula (I) or a salt, tautomer, solvate or N-oxide thereof; wherein R 1 is an optionally substituted...
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US20100003318 |
PROCESS FOR MAKING MULTIPARTICULATES USING A ROLLER COMPACTOR
A process for manufacturing multiparticulate pharmaceutical compositions using a roller compactor. The process is particularly useful for producing minitablets without the need of the use of a...
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US20100003256 |
Use of TGF-Beta Antagonists in Treatment of Parathyroid-Related Disorders
The present invention relates to the use of TGF-β antagonists for the treatment, amelioration, and diagnosis of parathyroid-related disorders, e.g., HPT-JT, familial isolated primary...
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7642379 |
Aminoacetonitrile derivatives and their use for controlling parasites on warm-blooded animals
The invention relates to compounds of the general formula (I) wherein Ar, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , W, a, b, m, n, o and p are as defined in claim 1 , and to any...
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7642278 |
Indazole benzimidazole compounds
Organic compounds having the structure I are provided where the variables have the values described herein.
A method of inhibiting c-ABL in a patient includes administering an effective amount...
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7641911 |
Immunological adjuvant compositions
The present invention is directed to novel adjuvant compositions, which target the cellular and/or humoral arms of immunity. According to an embodiment of the invention, an oil-in-water adjuvant...
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US20090326066 |
PROCESS FOR PREPARING BIARYL SUBSTITUTED 4-AMINO-BUTYRIC ACID OR DERIVATIVES THEREOF AND THEIR USE IN THE PRODUCTION OF NEP INHIBITORS
The invention relates to a process for producing a compound according to formula (i)
or salt thereof,
wherein R1 and R1′ are independently hydrogen or an amine protecting group and R2 is a...
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US20090324633 |
Immunogens from Uropathogenic Escherichia Coli
Disclosed herein are various genes that can be included in immunogenic compositions specific for pathogenic E. coli strains. The genes are from uropathogenic strains but are absent from...
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D606737 |
Combined pill container and lid
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7638679 |
Tolerance and chronic hepatitis C virus
This invention provides a model for the induction of immunological tolerance to antigens. The tolerance model of the invention can be used for screening candidate drugs effective in modulating...
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7638601 |
Transient receptor potential channel TRPM8 and its use
This invention provides novel genes and polypeptides of the transient receptor potential channel family, and use of these genes and polypeptides for the treatment of pain and identification of...
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7638523 |
Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors
Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity...
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7638510 |
Use of s-10-hydroxy-10,11-dihydro-carbamazepine for the treatment of anxiety and bipolar disorders
The present invention relates to the use of a racemate of the compound of formula (1) consisting of at least 85% S-enantiomer and not more than 15% R-enantiomer or of pharmaceutically acceptable...
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7638075 |
Colored printing ink for contact lenses
The present invention provides novels inks and methods for making a colored polymeric substrates, preferably a contact lens. In the inventive method at least a portion of a surface of a lens is...
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US20090318546 |
Chromen-2-One Derivatives
A compound of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , and ring A are as defined in the specification, processes for their production, their uses, in particular in...
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US20090318445 |
PDF INHIBITORS
The invention relates to novel compounds that are inhibitors of peptidyl deformylase (PDF). The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display...
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US20090318410 |
IMIDAZOPYRIDAZINES AS LIPID KINASE INHIBITORS
The invention relates to novel compounds of the formula I,
as well as other invention embodiments related to these compounds. The compounds are e.g. useful in the treatment of the animal or...
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US20090318390 |
COMBINATIONS COMPRISING EPOTHILONES AND PHARMACEUTICAL USES THEREOF
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I
wherein A represents O...
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US20090317827 |
Receptor In Dendritic Cells
The present invention provides the use of GPR91 as a target in dendritic cells.
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US20090317391 |
Cancer Related Genes (PTPE)
This invention is in the field of cancer-related genes. Specifically it relates to methods for detecting cancer or the likelihood of developing cancer based on the presence or absence of the...
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US20090317359 |
2,6-DISUBSTITUTED QUINAZOLINES, QUINOXALINES, QUINOLINES AND ISOQUINOLINES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
New substituted quinazoline, quinoxaline, quinoline and isoquinoline compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new...
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