Analogue-based drug discovery: contributions to medicinal chemistry principles and drug design strategies. Microtubule stabilizers as a case in point (special topic article).
Article Type:
Brief article
Pharmaceutical chemistry (Research)
Clinical chemistry (Research)
El-Dakdouki, Mohammad H.
Erhardt, Paul W.
Pub Date:
Name: Chemistry International Publisher: International Union of Pure and Applied Chemistry Audience: Academic Format: Magazine/Journal Subject: Chemistry; Engineering and manufacturing industries Copyright: COPYRIGHT 2012 International Union of Pure and Applied Chemistry ISSN: 0193-6484
Date: Sept-Oct, 2012 Source Volume: 34 Source Issue: 5
Event Code: 310 Science & research
Geographic Scope: United States Geographic Code: 1USA United States

Accession Number:
Full Text:
The benefits of utilizing marketed drugs as starting points to discover new therapeutic agents have been well documented within the IUPAC series of books that bear the title Analogue-based Drug Discovery (ABDD). Not as clearly demonstrated, however, is that ABDD also contributes to the elaboration of new basic principles and alternative drug design strategies that are useful to the field of medicinal chemistry in general. After reviewing the ABDD programs that have evolved around the area of microtubule-stabilizing chemo-therapeutic agents, the present article delineates the associated research activities that additionally contributed to general strategies that can be useful for prodrug design, identifying pharmacophores, circumventing multidrug resistance, and achieving targeted drug distribution.

Mohammad H. El-Dakdouki and Paul W. Erhardt Pure and Applied Chemistry, 2012 Vol. 84, No. 7, pp. 1479-1542
Gale Copyright:
Copyright 2012 Gale, Cengage Learning. All rights reserved.