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Human drug metabolism database.
Article Type:
Brief article
Databases (Design and construction)
Drug metabolism (Research)
Xenobiotics (Chemical properties)
Biochemistry (Research)
Pub Date:
Name: Chemistry International Publisher: International Union of Pure and Applied Chemistry Audience: Academic Format: Magazine/Journal Subject: Chemistry; Engineering and manufacturing industries Copyright: COPYRIGHT 2012 International Union of Pure and Applied Chemistry ISSN: 0193-6484
Date: Jan-Feb, 2012 Source Volume: 34 Source Issue: 1
Event Code: 310 Science & research Computer Subject: CD-ROM catalog; CD-ROM database; Database
Product Code: 8521210 Biochemistry NAICS Code: 54171 Research and Development in the Physical, Engineering, and Life Sciences
Geographic Scope: United States Geographic Code: 1USA United States

Accession Number:
Full Text:
This project will lay the foundation for establishing a relational database coupled with substructure searching capability pertaining to the metabolism of xenobiotics in humans. The database will eventually be made available on the internet via a nonprofit mechanism.

Accounting for all applicable clinical data in an unbiased manner with regard to study protocols, and across all human genotypes and assessed phenotypes, the database's critical mass will allow it to be utilized to develop more accurate and meaningful human structure-metabolism relationships (hSMR). Specific aspects of the overall hSMR, in turn, can then be applied in a proprietary fashion to assist in the selection and development of new drug candidates into and through clinical testing. Equally important at this juncture, the assembly of this type of database may be the only way to assess and potentially validate the actual utility of the numerous biochemical and in vitro methods that are proliferating in this field in order to predict the metabolic fate and metabolism-associated toxicity for a new xenobiotic upon its administration to humans.


For more information contact the task group chair Paul Erhardt .
Gale Copyright:
Copyright 2012 Gale, Cengage Learning. All rights reserved.