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7250518 |
Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
Compounds of the formula:
useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils.
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7183293 |
Ether derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds of the formula
wherein j is 1; k is 0 or 1; m is 1, 2 or 3; n is 1 or 2; W 1 and W 2 are independently —O— or —S(═O) t —, where t is 0, 1,...
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7071187 |
Naphthyridine derivatives
The present invention provides a novel naphthyridine derivative that is effective for relieving pain, less toxic, and also is effective for treating diabetic neuropathy, the derivative being...
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6953810 |
Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
Compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic bronchitis, and chronic obstructuive...
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6894041 |
Oxazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6869945 |
Pyrrolyl-and imidazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6828333 |
Ether derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds of the formula wherein j is 1; k is 0 or 1; m is 1, 2 or 3; n is 1 or 2; W 1 and W 2 are independently —O— or —S(═O) t —, where t is 0, 1,...
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6649633 |
Nicotinamide biaryl derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors at PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6559168 |
Thiazolyl-acid amide derivatives useful as inhibitors of PDE4 isozymes
This application is directed to compounds useful as inhibitors of PDE4 in the treatment of diseases regulated by the activation and degranulation of eosinophils, especially asthma, chronic...
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6245779 |
Naphthyridine derivatives
The present invention provides a naphthyridine derivative represented by the formula (1) ##STR1## wherein A is lower alkylene; R 1 is H or an electron pair "-"; R 2 is optionally substituted...
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