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7354909 |
Method for rapid generation of mature dendritic cells
Novel methods for rapidly generating dendritic cells are disclosed herein. The methods include contacting a dendritic cell precursor with a D ODN to generate a mature dendritic cell. In one...
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7250403 |
Biodegradable immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7223741 |
Immunostimulatory nucleic acid molecules
Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity,...
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7223398 |
Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof
The invention provides classes of immunomodulatory compositions which comprise an average of one or more immunostimulatory sequence (ISS) containing polynucleotide conjugated, or attached, to...
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7208478 |
Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which...
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7183111 |
Immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7157437 |
Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences
The invention provides new methods of preventing and/or treating herpes virus infections, particularly reducing infection, one or more symptoms and recurrence of one or more symptoms of herpes...
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7129222 |
Immunomodulatory formulations and methods for use thereof
The invention provides new compositions and methods for immunomodulation of individuals. Immunomodulation is accomplished by administration of immunomodulatory polynucleotide/microcarrier (IMP/MC)...
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7101556 |
Preparation and usage of plasmodium fusion antigen
The invention provides a fusion protein comprising the Plasmodium merozoite surface protein-1 (MSP1) and the Plasmodium apical membrane antigen 1 (AMA-1), the encoding DNA sequence, the vector...
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6977245 |
Oligodeoxynucleotide and its use to induce an immune response
D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula:
5′X 1 X 2 X 3 Pu 1 ...
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6951845 |
Method for treating allergic lung disease
The invention is directed to a method for treating both the early and late phases of allergic asthma by introducing naked polynucleotides which operatively encode for the asthma-initiating antigen...
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6610661 |
Immunostimulatory polynucleotide/immunomodulatory molecule conjugates
Immunostimulatory polynucleotide-immunomodulatory molecule conjugate compositions are disclosed. These compositions include a polynucleotide that is linked to an immunomodulatory molecule, which...
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