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7407792 |
Compositions, organisms and methodologies employing a novel human kinase
This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several...
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7402428 |
Modification of plant lignin content
DNA constructs comprising a first DNA segment that corresponds to at least a portion of a gene in the monolignol biosynthetic pathway, a spacer DNA segment, and a second DNA segment that is...
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EP1944361A1 |
A method for expanding monocytes
The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of MafB and c-Maf in monocytes,...
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7399586 |
Modulation of biological signal transduction by RNA interference
Compositions and methods relating to small interfering RNA (siRNA) polynucleotides are provided as pertains to modulation of biological signal transduction. Shown are siRNA polynucleotides that...
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7365186 |
Vascular-preferred promoter sequences and uses thereof
Plant polynucleotide promoter sequences are provided, together with DNA constructs comprising the inventive polynucleotide. Methods for using the inventive constructs for regulating gene expression...
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7358068 |
Antiviral oligonucleotides
Random sequence oligonucleotides that have antiviral activity are described, along with their use as antiviral agents. In many cases, the oligonucleotides are greater than 40 nucleotides in length....
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7357928 |
Method for the diagnosis and prognosis of malignant diseases
Methods for the treatment of tumors and cancer by exploiting the surface expression of the usually nuclear-localized protein, nucleolin.
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7351578 |
Use of multiple recombination sites with unique specificity in recombinational cloning
The present invention provides compositions and methods for recombinational cloning. The compositions include vectors having multiple recombination sites with unique specificity. The methods permit...
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7348314 |
Compositions and methods for inhibiting viral replication
The present invention relates to a double-stranded ribonucleic acid (dsRNA) having a nucleotide sequence which is less that 30 nucleotides in length and which is substantially identical to at least...
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7345027 |
Compositions and methods for siRNA inhibition of angiogenesis
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these...
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EP1886685A1 |
Methods, uses and compositions for modulating replication of hcv through the farnesoid x receptor (fxr) activation or inhibition
The present invention relates to uses, methods and compositions for modulating replication of viruses of the Flaviviridae family, such as hepatitis C virus, through the farnesoid X receptor (FXR)...
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7326768 |
Goodpasture antigen-binding protein isoforms and protein misfolded-mediated disorders
The present invention provides novel isoforms of the Goodpasture antigen binding protein (GPBP), and related reagents, and also provides methods for isolating and detecting such novel GPBP...
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7323310 |
Methods and compositions for RNA amplification and detection using an RNA-dependent RNA-polymerase
Methods and compositions are provided for amplifying RNA from an RNA template. Methods and compositions are further provided for detecting an RNA in an RNA containing sample. Compositions used for...
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7297779 |
Colon cancer metastasis inhibitor
The present invention provides an agent for inhibiting metastasis of colorectal cancer and a method for inhibiting metastasis of colorectal cancer, which inhibit the function of Asef (i.e., binding...
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7297525 |
Composition employing a novel human kinase
This invention provides compositions, organisms and methodologies employing a novel human protein kinase, MCRK1. The novel human kinase has sequence homology to rat myotonic dystrophy...
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7294504 |
Methods and compositions for DNA mediated gene silencing
DNA compositions that mediate gene silencing via RNA interference are provided. Also provided are methods of using such compositions to silence gene expression in a cell.
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EP1818405A2 |
Compositions and methods for control of insect infestations in plants
The present invention is directed to controlling pest infestation by inhibiting one or more biological functions in an invertebrate pest. The invention discloses methods and compositions for use in...
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EP1818404A2 |
Genes and uses for plant improvement
Transgenic seed for crops with improved traits are provided by trait-improving recombinant DNA where plants grown from such transgenic seed exhibit one or more improved traits as compared to a...
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7256329 |
Nucleic acid sequences and methods of use for the production of plants with modified polyunsaturated fatty acids
By this invention, novel nucleic acid sequences are provided, wherein said nucleic acid sequence is a genomic sequence of a plant desaturase encoding sequence. Also provided in the present...
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7255860 |
Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody
The invention features methods and compositions for preventing or treating post-surgical pain by administering an anti-NGF antagonist antibody.
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7252822 |
Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist
The invention features methods and compositions for preventing or treating pain resulting from surgery or an incision by administering an antagonist of nerve growth factor (NGF). The NGF antagonist...
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EP1793003A1 |
CITED4 as prognostic marker in oligodendroglial tumors
The present invention provides novel (diagnostic) methods of detecting cancer of the central nervous system, preferably oligodendrogliomas, by detecting the presence of CITED4-nucleic acid...
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7208306 |
Compositions employing a novel human protein phosphatase
This invention provides compositions, organisms and methodologies employing a novel human gene encoding a protein that has sequence homology to a consensus sequence of calcineurin-like...
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7196184 |
Double-stranded RNA (DSRNA) and method of use for inhibiting expression of the AML-1/MTG8 fusion gene
The present invention relates to the specific inhibition of expression of a fusion gene in mammals using a short double stranded RNA. The dsRNA is approximately 19–24 nucleotides in length, and...
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7195916 |
Method for expression of small antiviral RNA molecules within a cell
In one aspect, the invention provides methods and compositions for the expression of small RNA molecules within a cell using a retroviral vector. The methods can be used to express double stranded...
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7179796 |
Antisense modulation of PTP1B expression
Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic...
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7176304 |
RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
The present invention concerns methods and reagents useful in modulating vascular endothelial growth factor (VEGF, VEGF-A, VEGF-B, VEGF-C, VEGF-D) and/or vascular endothelial growth factor receptor...
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EP1741781A2 |
RNA interference mediated treatment of Alzheimer's disease using short interfering nucleic acid (siNA)
The present invention concerns methods and reagents useful in modulating BACE gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic...
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7148342 |
Compositions and methods for sirna inhibition of angiogenesis
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these...
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7129087 |
Oligonucleotide-facilitated coalescence
Coalescence of cells or other membrane-bound entities is facilitated by anchoring an outwardly projecting first oligonucleotide in one member and an outwardly projecting second oligonucleotide,...
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7122361 |
Compositions employing a novel human kinase
This invention provides compositions, organisms and methodologies employing a novel human protein kinase, HPK3P23. The novel human kinase has sequence homology to the catalytic domains of several...
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EP1710307A2 |
RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
The present invention concerns methods for reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic...
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7022828 |
siRNA treatment of diseases or conditions related to levels of IKK-gamma
The present invention relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, allozymes, aptamers, decoys and siRNA...
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7019195 |
Method for conferring resistance or tolerance aganist furovirus, potyvirus, tospovirus, and cucomovirus to plant cells
The present invention relates to a method to confer resistance or tolerance to more than one virus from the group consisting of furovirus, potyvirus, tospovirus, and cucomovirus, using sense and...
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7005423 |
Characterization of gene function using double stranded RNA inhibition
There is provided a method of identifying DNA responsible for conferring a particular phenotype in a cell which method comprises a) constructing a cDNA or genomic library of the DNA of the cell in...
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6939712 |
Muting gene activity using a transgenic nucleic acid
The invention provides compositions and methods for muting expression of an endogenous gene in an animal cell, the muting resulting from providing a transgene to a cell. Expression of which...
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6924109 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6759574 |
Plants having enhanced gall resistance and methods and compositions for producing same
Methods and compositions for suppressing gall formation in plant cells induced by Agrobacterium infection are disclosed. The methods involve introducing at least one DNA construct, encoding at...
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