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7405831 |
Laser scanning interferometric surface metrology
An apparatus for assessing topology of a surface of a target including an optical source for generating a probe laser beam. The apparatus also includes a means for scanning the probe laser beam...
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7403647 |
Method for identifying an image of a well in an image of a well-bearing component
A method for identifying images of wells in an image of a well-bearing object such as multiwell plates or picowell carriers is provided. An observation component, such as a camera, is used to...
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7323318 |
Assay for distinguishing live and dead cells
Image analysis methods and apparatus are used for distinguishing live and dead cells. The methods may involve segmenting an image to identify the region(s) occupied by one or more cells and...
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7317820 |
System and method for automatically identifying sub-grids in a microarray
A digital image processing-based system and method for quantitatively processing a plurality of nucleic acid species expressed in a microarray are disclosed. The microarray is a grid of a plurality...
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7302348 |
Method and system for quantifying and removing spatial-intensity trends in microarray data
A method and system for quantifying and correcting spatial-intensity trends for each channel of a microarray data set having one or more channels. The method and system of one embodiment of the...
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7269278 |
Extracting shape information contained in cell images
Methods and apparatus are provided for the analysis of images of cells and extraction biologically-significant shape-related features from the cell images. The extracted features may be correlated...
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7262858 |
Apparatus and method for accessing and processing reflection image from microwell-plate-based biochip
An apparatus accesses and processes reflection images detected from microarray biochips with sidewalls. The apparatus uses a movable system to carry an optical module and a microtiter plate to...
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7246012 |
Characterizing biological stimuli by response curves
A method for calculating distances between stimulus response curves (e.g., dose response curves) allows classification of stimuli. The response curves show how the phenotype of one or more cells...
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7235353 |
Predicting hepatotoxicity using cell based assays
Cell based assays are used to assess the hepatotoxicity of a stimulus. Imaging technologies are used to analyze the effects of a stimulus on hepatocytes. Image analysis may characterize the...
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7218764 |
Ploidy classification method
Image analysis methods and apparatus are used for determination of the ploidy of cells. The methods may involve segmenting an image to identify one or more discrete regions occupied by cells or...
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7099502 |
System and method for automatically processing microarrays
A digital image processing-based system and method for quantitatively processing a plurality of nucleic acid species expressed in a microarray are disclosed. The microarray is a grid of a plurality...
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7027629 |
Method of extracting locations of nucleic acid array features
Methods for correcting systematic errors in the measured position of deposited features of a nucleic acid array on a substrate. Systematic errors are modeled by an algorithmic model based on...
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7006741 |
Contact-field optical microscope
A broad-spectrum, high spatial and time resolution contact-field optical microscope comprises a fiber optical taper, a vacuum chamber, a photocathode, a magnetic lens photoelectron image enlarger,...
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6990221 |
Automated DNA array image segmentation and analysis
A segmentation method of a frame of image information including a plurality of spaced DNA spot images corresponding to a plurality of DNA spots. The image information includes image intensity level...
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6965704 |
System, method, and computer software product for grid alignment of multiple scanned images
Systems, methods, and computer program products are described for aligning multiple images of arrays of biological materials. One method includes aligning a grid with a first image, generating grid...
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6956961 |
Extracting shape information contained in cell images
Methods and apparatus are provided for the analysis of images of cells and extraction biologically-significant shape-related features from the cell images. The extracted features may be correlated...
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6927903 |
Rapidly changing dichroic beamsplitter
An epi-fluorescent microscope is constructed with a quick changing set of filters. A wheel containing a plurality of dichroic beamsplitter mirrors mounted equidistance from a center axis of the...
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6888630 |
Biochip reader
The present invention provides a biochip reader for reading with a detector the fluorescence image information from genes to which fluorescent substances are stuck and which are poured into biochip...
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6876760 |
Classifying cells based on information contained in cell images
Image analysis methods analyze images of cells and place the cells in particular cell cycle phases based upon certain features extracted from the images. The methods can also quantify the total...
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6873410 |
Biochip reader
The present invention provides a biochip reader for reading with a detector the fluorescence image information from genes to which fluorescent substances are stuck and which are poured into biochip...
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6867860 |
Biochip reader
The present invention provides a biochip reader for reading with a detector the fluorescence image information from genes to which fluorescent substances are stuck and which are poured into biochip...
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6864976 |
Biochip reader
The present invention provides a biochip reader for reading with a detector the fluorescence image information from genes to which fluorescent substances are stuck and which are poured into biochip...
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6839454 |
System and method for automatically identifying sub-grids in a microarray
A digital image processing-based system and method for quantitatively processing a plurality of nucleic acid species expressed in a microarray are disclosed. The microarray is a grid of a plurality...
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6828568 |
Process for testing of fluophors and device for carrying out the process
A method and apparatus for increasing the emission amount of red such that it is made the same as the emission amount of green and blue, to enable the application state of the fluophors to be...
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6743576 |
Database system for predictive cellular bioinformatics
A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a...
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6738716 |
Database system for predictive cellular bioinformatics
A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a...
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6731781 |
System and method for automatically processing microarrays
A digital image processing-based system and method for quantitatively processing a plurality of nucleic acid species expressed in a microarray are disclosed. The microarray is a grid of a plurality...
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6714675 |
Autogrid analysis
A method and apparatus for identifying the orientation and positions of the elements of a grid in an image. The elements of the grid need not be parallel to the sides of the image, and the image...
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6674882 |
Automated DNA array image segmentation and analysis
A segmentation method of a frame of image information including a plurality of spaced DNA spot images corresponding to a plurality of DNA spots. The image information includes image intensity level...
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6651008 |
Database system including computer code for predictive cellular bioinformatics
According to the present invention, computer based techniques for using information technology in therapeutics or drug discovery. In an exemplary embodiment, computer based techniques for...
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6633669 |
Autogrid analysis
A method and apparatus for identifying the orientation and positions of the elements of a grid in an image. The elements of the grid need not be parallel to the sides of the image, and the image...
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6631331 |
Database system for predictive cellular bioinformatics
A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a...
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6615141 |
Database system for predictive cellular bioinformatics
A system for acquiring knowledge from cellular information. The system has a database comprising a database management module (“DBMS”). The system also has a variety of modules, including a...
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6599694 |
Method of characterizing potential therapeutics by determining cell-cell interactions
A method quantitatively analyzes images of two different cell types that interact in producing and maintaining a disease state or other biological condition. The two separate cell types are exposed...
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6510237 |
System for determining the concentration of a substance mixed with a fluorophor, its method of implementation
The invention concerns a system, and its method of implementation, to determine the concentration of a substance mixed with a fluorophor and contained in one or more contacts of a matrix of...
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6498863 |
Method, system, and product for analyzing a digitized image of an array to create an image of a grid overlay
A method, system, and product for analyzing a digitized image of an array to create an image of a grid overlay. The method comprising the steps of locating the center of each object on the array,...
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