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7427631 |
Metalloproteinase inhibitors
Compounds of the formula (I) wherein z is SO 2 or SO, useful as metalloproteinase inhibitors, especially as inhibitors of MMP12.
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7368465 |
Metalloproteinase inhibitors
Compounds of the formula (I) wherein Z is SO 2 (N6) or N(R7)SO 2 or N(R7)SO 2 N(R6) useful as metalloproteinase inhibitors, especially as inhibitors of MMP12.
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7354940 |
2,5-dioxoimidazolidin-4-yl acetamines and analogues as inhibitors of metalloproteinase mmp12
The invention provides compounds of formula (I) in which L, X, Y, Z 1 , Z 2 , R 1 , R 2 , R 3 and G 2 have the meanings defined in the specification; processes for their preparation;...
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EP1865001A1 |
Specific protease inhibitors and their use in cancer therapy
The present invention relates to a pharmaceutical composition comprising at least one inhibitor of EpCAM cleavage and at least one anti-EpCAM antibody, the use of least one inhibitor of EpCAM...
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7282496 |
Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and TACE inhibitors
Compounds of the formula
are useful in treating disease conditions mediated by TNF-α, such as rheumatoid arthritis, osteoarthritis, sepsis, AIDS, ulcerative colitis, multiple sclerosis,...
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7132434 |
Metalloproteinase inhibitors
Compounds of the formula (I), useful as metal-loproteinase inhibitors, especially as inhibitors of MMP12
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6753337 |
Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
Compounds of the formula: useful in the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and...
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