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7387891 |
Optical instrument including excitation source
An optical instrument is provided for simultaneously illuminating two or more spaced-apart reaction regions with an excitation beam generated by a light source. A collimating lens can be disposed...
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7368245 |
Method and probes for the detection of chromosome aberrations
A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at...
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7359116 |
Microscope turret mounted laser EPI-illumination port
An optical injection system for use in conjunction with a microscope having a turret supporting an objective having an optical path is provided. The optical injection system includes a dichroic...
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7315371 |
Multi-channel spectrum analyzer
A spectrum analyzer for the simultaneous analysis of electromagnetic radiation delivered to it from either multiple sources or from a linear segment along a source surface, and arranged as either...
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7294487 |
Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
The present invention relates to a method for the detection of gene expression and analysis of both known and unknown genes. The invention is a highly sensitive, rapid and cost-effective means of...
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7265833 |
Electrophoretic system with multi-notch filter and laser excitation source
Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for...
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7259253 |
Genes associated with mechanical stress, expression products therefrom, and uses thereof
The disclosure relates to human and mechanical stress induced genes, in particular gene 608, and functional equivalents, probes therefor, tests to identify such genes, polypeptide expression...
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7221447 |
Consumable for laser capture microdissection
Systems and methods for acquiring laser capture microdissection samples are disclosed. A scattering media is located within a beam path defined by the laser capture microdissection microscope and...
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7211807 |
Readout method performed by stripe scanning planar objects with substances emitting fluorescence radiation
The subject matter of the invention is a readout method performed by stripe scanning planar objects with substances emitting fluorescence radiation, a detector being provided and said fluorescence...
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7183103 |
Instrument for monitoring polymerase chain reaction of DNA
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of...
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7132239 |
Determination of a genotype of an amplification product at multiple allelic sites
A method is provided for genotyping a target sequence at at least two allelic sites by a 5′ nuclease amplification reaction. In one embodiment, the method includes performing a nucleic acid...
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7115370 |
Combinatorial oligonucleotide PCR
The present invention is directed to a method of detecting gene expression and analysis of both known and unknown genes. In the method utilizing combinatorial oligonucleotide PCR™, no single...
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7105294 |
Method and probes for the detection of chromosome aberrations
A novel method for detecting chromosome aberrations is disclosed. More specifically, chromosome aberrations are detected by in situ hybridisation using at least two sets of hybridisation probes, at...
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7075640 |
Consumable for laser capture microdissection
Systems and methods for acquiring laser capture microdissection samples are disclosed. An integral portion of a biological reaction vessel includes a transfer film carrier having a substrate...
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7034144 |
Molecular detection of chromosome aberrations
The invention relates to the field of cytogenetics and the application of genetic diagnostic techniques in pathology and hematology. Specifically, the invention relates to nucleic acid probes that...
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7026111 |
Methods and reagents for improved cell-based assays
The ability to efficiently determine the state of enzyme expression in cells has long been desired as material to the diagnosis of disease. This invention relates to cytoenzymology, and more...
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7008789 |
Instrument for monitoring polymerase chain reaction of DNA
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of...
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6897038 |
Method of laser capture microdissection from a sample utilizing short pulse length
Laser capture microdissection occurs where the transfer polymer film is placed on a substrate overlying visualized and selected cellular material from a sample for extraction. The transfer polymer...
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6887703 |
Transfer film for laser microcapture
The present invention generally provides an improved transfer film having multiple layers for laser micro-capture of a sample. The transfer film for laser micro-capture includes distinct layers for...
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6884583 |
Determination of a genotype of an amplification product at multiple allelic sites
A method is provided for genotyping a target sequence at at least two allelic sites by a 5′ nuclease amplification reaction. In one embodiment, the method includes performing a nucleic acid...
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6842535 |
Imaging system
An imaging system is provided where radiation from object space ( 2 ) is incident on an array of detector elements ( 8 ) via an interferometer ( 3 ), the interferometer ( 3 ) Being scanned such...
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6818437 |
Instrument for monitoring polymerase chain reaction of DNA
An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of...
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6783734 |
Convex geometry adhesive film system for laser capture microdissection
A tissue sample is conventionally visualized in a microscope. A selectively activated convex surface is provided, preferably at the distal end of a rod. This selectively activated convex surface...
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6754375 |
Method and system for interactively developing at least one grid pattern and computer-readable storage medium having a program for executing the method
Method and system are disclosed for interactively developing at least one grid pattern, such as a microarray pattern, as well as an array set of such patterns, and a computer-readable storage...
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6656687 |
Multiplex PNA-ISH assay
This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and/or eucarya. Preferred universal probes for the detection of...
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EP1288308A1 |
A method for the determination of multiple analytes
The present invention is directed to a method for the determination of at least 3 analytes using specific binding partners. Combinations of detectable labels are coupled to the binding partners...
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6528248 |
Processing technology for LCM samples
Systems and methods are described for barriers on laser capture microdissection samples. A method of processing a biological sample for laser capture microdissection, includes: providing the...
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6495195 |
Broadband absorbing film for laser capture microdissection
A thermoplastic film for LCM tissue transfer is thermally coupled to a broadband energy-absorbing material. The broadband energy-absorbing material may either be introduced into the film...
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6469779 |
Laser capture microdissection method and apparatus
Systems and methods for laser capture microdissection are disclosed. A method of laser capture microdissection includes providing a sample that is to undergo laser capture microdissection;...
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6420132 |
Precision laser capture microdissection utilizing short pulse length
Laser capture microdissection occurs where the transfer polymer film is placed on a substrate overlying visualized and selected cellular material from a sample for extraction. The transfer polymer...
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6362832 |
Method and system for overlaying at least three microarray images to obtain a multicolor composite image
Method and system for overlaying at least three microarray images to obtain a multicolor composite image, which is then displayed on a monitor of a computer system. The microarray images are taken...
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6154707 |
Computer logic for fluorescence genotyping at multiple allelic sites
A method is provided for genotyping a target sequence at at least two allelic sites by a 5' nuclease amplification reaction. In one embodiment, the method includes performing a nucleic acid...
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6140057 |
Method for detecting a pericentric inversion in a chromosome
A method is provided for determining a clastogenic signature of a sample of chromosomes by quantifying a frequency of a first type of chromosome aberration present in the sample; quantifying a...
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EP1035215A2 |
Method and probe set for detecting cancer
Methods for detecting cancer that include hybridizing a set of chromosomal probes to a biological sample obtained from a patient, and identifying if aneusomic cells are present in a selected subset...
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6100051 |
Method utilizing convex geometry for laser capture microdissection
A process of microdissection where a tissue sample is conventionally visualized in a microscope. A selectively activatable convex surface is provided, preferably on the periphery at the distal end...
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5962233 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** Determination of a genotype of an amplification product at multiple allelic sites
A method is provided for genotyping a target sequence at at least two allelic sites by a 5' nuclease amplification reaction. In one embodiment, the method includes performing a nucleic acid...
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